F2RL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the G-protein coupled receptor 1 family of proteins. The encoded cell surface receptor is activated through proteolytic cleavage of its extracellular amino terminus, resulting in a new amino terminus that acts as a tethered ligand that binds to an extracellular loop domain. Activation of the receptor has been shown to stimulate vascular smooth muscle relaxation, dilate blood vessels, increase blood flow, and lower blood pressure. This protein is also important in the inflammatory response, as well as innate and adaptive immunity. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)5.71684478
2regulation of posttranscriptional gene silencing (GO:0060147)5.70619371
3regulation of gene silencing by miRNA (GO:0060964)5.70619371
4regulation of gene silencing by RNA (GO:0060966)5.70619371
5desmosome organization (GO:0002934)5.56768871
6intestinal epithelial cell development (GO:0060576)5.39047439
7Golgi transport vesicle coating (GO:0048200)5.28999005
8COPI coating of Golgi vesicle (GO:0048205)5.28999005
9bundle of His cell to Purkinje myocyte communication (GO:0086069)4.86038768
10cell adhesion mediated by integrin (GO:0033627)4.78454271
11regulation of hippo signaling (GO:0035330)4.56076383
12skin morphogenesis (GO:0043589)4.41709177
13negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)4.33227110
14regulation of Wnt signaling pathway involved in heart development (GO:0003307)4.22802185
15trophectodermal cell differentiation (GO:0001829)4.21550077
16protein maturation by protein folding (GO:0022417)4.14571256
17regulation of water loss via skin (GO:0033561)4.12298852
18nuclear pore complex assembly (GO:0051292)4.12227656
19nuclear pore organization (GO:0006999)3.98684983
20establishment of apical/basal cell polarity (GO:0035089)3.82808054
21maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.80507593
22regulation of transforming growth factor beta2 production (GO:0032909)3.75924419
23regulation of helicase activity (GO:0051095)3.75455860
24protein localization to endosome (GO:0036010)3.69091865
25protein retention in ER lumen (GO:0006621)3.68791510
26establishment of integrated proviral latency (GO:0075713)3.58000696
27paraxial mesoderm development (GO:0048339)3.53453879
28anterior/posterior axis specification, embryo (GO:0008595)3.52028917
29positive regulation of SMAD protein import into nucleus (GO:0060391)3.50285954
30hepatocyte apoptotic process (GO:0097284)3.46698589
31negative regulation of keratinocyte proliferation (GO:0010839)3.44793479
32epithelial cell-cell adhesion (GO:0090136)3.44771775
33hypotonic response (GO:0006971)3.39993905
34intestinal absorption (GO:0050892)3.39068800
35proline biosynthetic process (GO:0006561)3.38496305
36establishment of skin barrier (GO:0061436)3.36264162
37nucleotide-sugar biosynthetic process (GO:0009226)3.28401464
38regulation of metalloenzyme activity (GO:0048552)3.26294906
39tight junction assembly (GO:0070830)3.23385443
40apoptotic process involved in morphogenesis (GO:0060561)3.22099665
41heterochromatin organization (GO:0070828)3.19293745
42* interferon-gamma secretion (GO:0072643)3.18410356
43establishment or maintenance of monopolar cell polarity (GO:0061339)3.16455449
44establishment of monopolar cell polarity (GO:0061162)3.16455449
45cell differentiation involved in embryonic placenta development (GO:0060706)3.16381123
46regulation of gene silencing (GO:0060968)3.14871686
47embryonic process involved in female pregnancy (GO:0060136)3.12370698
48ribosome assembly (GO:0042255)3.12288111
49branching involved in mammary gland duct morphogenesis (GO:0060444)3.12184562
50pore complex assembly (GO:0046931)3.08499408
51determination of adult lifespan (GO:0008340)3.08073540
52establishment of viral latency (GO:0019043)3.06950765
53cellular copper ion homeostasis (GO:0006878)3.03339355
54embryonic camera-type eye development (GO:0031076)3.01119329
55protein autoprocessing (GO:0016540)3.00022287
56positive regulation of Cdc42 GTPase activity (GO:0043089)3.00012696
57actin filament depolymerization (GO:0030042)2.99602004
58COPII vesicle coating (GO:0048208)2.98134341
59hepatocyte differentiation (GO:0070365)2.97595320
60keratinocyte differentiation (GO:0030216)2.97469806
61regulation of SMAD protein import into nucleus (GO:0060390)2.96558553
62regulation of translational fidelity (GO:0006450)2.95008348
63regulation of cholesterol homeostasis (GO:2000188)2.93176489
64notochord development (GO:0030903)2.92476417
65regulation of epidermal growth factor-activated receptor activity (GO:0007176)2.90804873
66nodal signaling pathway (GO:0038092)2.89743693
67multicellular organismal water homeostasis (GO:0050891)2.86631295
68cell fate commitment involved in formation of primary germ layer (GO:0060795)2.83550157
69negative regulation of cell fate specification (GO:0009996)2.82959100
70keratinocyte development (GO:0003334)2.81738614
71formation of translation preinitiation complex (GO:0001731)2.80816548
72activation of Rac GTPase activity (GO:0032863)2.79905772
73mesodermal cell differentiation (GO:0048333)2.78219539
74positive regulation of substrate adhesion-dependent cell spreading (GO:1900026)2.77612283
75polarized epithelial cell differentiation (GO:0030859)2.73558011
76protein hydroxylation (GO:0018126)2.72880516
77negative regulation of protein tyrosine kinase activity (GO:0061099)2.72702193
78cell-substrate junction assembly (GO:0007044)2.71540671
79dosage compensation (GO:0007549)2.69411289
80negative regulation of anoikis (GO:2000811)2.68687494
81retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.68110283
82substrate-dependent cell migration (GO:0006929)2.67999415
83pre-miRNA processing (GO:0031054)2.66887447
84histone H4-K12 acetylation (GO:0043983)2.66870141
85renal absorption (GO:0070293)2.66700146
86UDP-N-acetylglucosamine metabolic process (GO:0006047)2.66206776
87epidermal cell differentiation (GO:0009913)2.65065564
88regulation of cell fate specification (GO:0042659)2.64912352
89branching involved in labyrinthine layer morphogenesis (GO:0060670)2.63665057
90very-low-density lipoprotein particle assembly (GO:0034379)2.62997294
91regulation of transforming growth factor beta1 production (GO:0032908)2.62980704
92renal filtration (GO:0097205)2.60242465
93columnar/cuboidal epithelial cell development (GO:0002066)2.59247003
94mitotic nuclear envelope disassembly (GO:0007077)2.58680976
95folic acid-containing compound biosynthetic process (GO:0009396)2.55822527
96intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)2.55691910
97cellular response to vitamin D (GO:0071305)2.55400641
98membrane raft organization (GO:0031579)2.55149183
99gap junction assembly (GO:0016264)2.52663608
100ectoderm development (GO:0007398)2.52582200
101protein localization to kinetochore (GO:0034501)2.52168292
102regulation of substrate adhesion-dependent cell spreading (GO:1900024)2.51354714
103calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.49795778
104maturation of SSU-rRNA (GO:0030490)2.49169912
105somatic diversification of immune receptors via somatic mutation (GO:0002566)2.47900622
106somatic hypermutation of immunoglobulin genes (GO:0016446)2.47900622
107mammary gland development (GO:0030879)2.47579020
108keratinization (GO:0031424)2.47098712
109regulation of keratinocyte differentiation (GO:0045616)2.47044711
110positive regulation of epidermis development (GO:0045684)2.46814159
111mammary gland epithelial cell proliferation (GO:0033598)2.46402466
112regulation of cardioblast differentiation (GO:0051890)2.46135262
113glomerular visceral epithelial cell development (GO:0072015)2.46092400
114hippo signaling (GO:0035329)2.45993424
115intestinal cholesterol absorption (GO:0030299)2.44923693
116regulation of apoptotic process involved in morphogenesis (GO:1902337)2.44863745
117glutamine family amino acid biosynthetic process (GO:0009084)2.44238336
118positive regulation of epidermal cell differentiation (GO:0045606)2.44004210
119regulation of telomere maintenance via telomerase (GO:0032210)2.43694167
120vesicle coating (GO:0006901)2.43141084
121bone remodeling (GO:0046849)2.43031036
122regulation of keratinocyte proliferation (GO:0010837)2.42840001
123cytoskeletal anchoring at plasma membrane (GO:0007016)2.42827750
124plasma lipoprotein particle assembly (GO:0034377)2.42713988
125positive regulation of establishment of protein localization to plasma membrane (GO:0090004)2.41684920
126peptidyl-proline hydroxylation (GO:0019511)2.40745431
127regulation of translational termination (GO:0006449)2.40693913
128membrane disassembly (GO:0030397)2.40687753
129nuclear envelope disassembly (GO:0051081)2.40687753
130regulation of integrin activation (GO:0033623)2.40468272
131muscle cell migration (GO:0014812)2.40234014
132regulation of histone H3-K9 methylation (GO:0051570)2.39873128
133morphogenesis of embryonic epithelium (GO:0016331)2.38689323
134wound healing, spreading of epidermal cells (GO:0035313)2.37943267
135wound healing, spreading of cells (GO:0044319)2.37135622
136keratinocyte proliferation (GO:0043616)2.36229933
137nuclear envelope reassembly (GO:0031468)2.35572915
138mitotic nuclear envelope reassembly (GO:0007084)2.35572915
139negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.34728814
140endothelial tube morphogenesis (GO:0061154)2.34408005
141morphogenesis of an endothelium (GO:0003159)2.34408005
142DNA duplex unwinding (GO:0032508)2.34283878
143DNA geometric change (GO:0032392)2.33683400
144SMAD protein complex assembly (GO:0007183)2.33680285
145regulation of chromatin silencing (GO:0031935)2.33589231
146regulation of transforming growth factor beta production (GO:0071634)2.33541758
147cell surface receptor signaling pathway involved in heart development (GO:0061311)2.32261186
148cellular glucuronidation (GO:0052695)2.31573106
149negative regulation of stem cell proliferation (GO:2000647)2.31151806
150negative regulation of cell fate commitment (GO:0010454)2.30644848
151regulation of sister chromatid cohesion (GO:0007063)2.30418311
152proline metabolic process (GO:0006560)2.29981355
153muscle organ morphogenesis (GO:0048644)2.29337206
154barbed-end actin filament capping (GO:0051016)2.28629260
155membrane protein ectodomain proteolysis (GO:0006509)2.28388622
156negative regulation of chondrocyte differentiation (GO:0032331)2.28281925
157ribosomal small subunit biogenesis (GO:0042274)2.28156353
158long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.28100679
159negative regulation of receptor activity (GO:2000272)2.28093346
160viral transcription (GO:0019083)2.27541561
161protein localization to microtubule (GO:0035372)2.27026316
162cell-cell junction assembly (GO:0007043)2.26654234
163regulation of viral release from host cell (GO:1902186)2.26213823
164GDP-mannose metabolic process (GO:0019673)2.25870931
165regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.25838607
166ribosomal large subunit biogenesis (GO:0042273)2.25516720
167ear development (GO:0043583)2.24102605
168chromatin assembly (GO:0031497)2.23896914
169developmental programmed cell death (GO:0010623)2.23742191
170regulation of nuclear cell cycle DNA replication (GO:0033262)2.23711755
171negative regulation of gene silencing (GO:0060969)2.23565097
172establishment or maintenance of apical/basal cell polarity (GO:0035088)2.23171417
173establishment or maintenance of bipolar cell polarity (GO:0061245)2.23171417
174translational termination (GO:0006415)2.22645847

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human8.18475573
2E2F7_22180533_ChIP-Seq_HELA_Human4.84430891
3KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.89799281
4KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.89799281
5KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.89799281
6TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.24803479
7* SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.79743543
8EGR1_19374776_ChIP-ChIP_THP-1_Human2.71408943
9NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.67244279
10POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.64927879
11FOXM1_23109430_ChIP-Seq_U2OS_Human2.61295096
12* SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.58698395
13TCF3_18692474_ChIP-Seq_MEFs_Mouse2.53685498
14ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.37934798
15* NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.34302896
16SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.30673009
17SALL1_21062744_ChIP-ChIP_HESCs_Human2.26163623
18SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.23419951
19MYC_18555785_ChIP-Seq_MESCs_Mouse2.23134436
20TCF3_18692474_ChIP-Seq_MESCs_Mouse2.18668499
21MYC_19079543_ChIP-ChIP_MESCs_Mouse2.17451202
22ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.11775856
23ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.09537658
24HIF1A_21447827_ChIP-Seq_MCF-7_Human1.99267890
25STAT3_1855785_ChIP-Seq_MESCs_Mouse1.98373182
26FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.98152158
27CLOCK_20551151_ChIP-Seq_293T_Human1.91554420
28NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.90879478
29* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.90766861
30NANOG_18555785_ChIP-Seq_MESCs_Mouse1.89207964
31ESR1_21235772_ChIP-Seq_MCF-7_Human1.88992348
32HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.79617207
33* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.71495499
34POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.71168020
35CDX2_20551321_ChIP-Seq_CACO-2_Human1.67643321
36NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.66924387
37MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.66919059
38ELK3_25401928_ChIP-Seq_HUVEC_Human1.66912106
39E2F4_17652178_ChIP-ChIP_JURKAT_Human1.65448576
40DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.64904369
41* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.63318824
42SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.62735563
43AR_21909140_ChIP-Seq_LNCAP_Human1.61428748
44GATA6_25053715_ChIP-Seq_YYC3_Human1.59208249
45* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.58313121
46* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.58313121
47* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.55689170
48NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.54083993
49* NANOG_18692474_ChIP-Seq_MEFs_Mouse1.53215209
50KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.52710257
51SOX2_18555785_ChIP-Seq_MESCs_Mouse1.52276012
52SOX2_27498859_Chip-Seq_STOMACH_Mouse1.48886044
53EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.46452600
54ZNF263_19887448_ChIP-Seq_K562_Human1.46282071
55KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.44880434
56POU5F1_16518401_ChIP-PET_MESCs_Mouse1.44875687
57RXR_22158963_ChIP-Seq_LIVER_Mouse1.42460462
58ESR2_21235772_ChIP-Seq_MCF-7_Human1.41865661
59* FOXO3_23340844_ChIP-Seq_DLD1_Human1.41822253
60* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.40248707
61* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.38203138
62ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.38194695
63* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.35607608
64* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.34668123
65SALL4_18804426_ChIP-ChIP_XEN_Mouse1.34546712
66ZFX_18555785_ChIP-Seq_MESCs_Mouse1.34510898
67MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.32558645
68KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.32308098
69GATA2_21666600_ChIP-Seq_HMVEC_Human1.32183627
70PPARA_22158963_ChIP-Seq_LIVER_Mouse1.31897951
71TP63_19390658_ChIP-ChIP_HaCaT_Human1.31358596
72* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.30532433
73HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.29778967
74ATF3_27146783_Chip-Seq_COLON_Human1.29475225
75OCT4_18692474_ChIP-Seq_MEFs_Mouse1.29068363
76PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.27522320
77ESR1_15608294_ChIP-ChIP_MCF-7_Human1.25942830
78STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.25062610
79NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.24047343
80P300_27058665_Chip-Seq_ZR-75-30cells_Human1.23278645
81GATA4_25053715_ChIP-Seq_YYC3_Human1.22413340
82UBF1/2_26484160_Chip-Seq_HMECs_Human1.21711332
83MYC_22102868_ChIP-Seq_BL_Human1.19419679
84* PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.18301966
85* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.17510496
86RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.16478844
87* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.14363128
88DCP1A_22483619_ChIP-Seq_HELA_Human1.13943110
89RACK7_27058665_Chip-Seq_MCF-7_Human1.11842687
90RUNX1_27514584_Chip-Seq_MCF-7_Human1.11536665
91PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.11515176
92* GATA3_24758297_ChIP-Seq_MCF-7_Human1.11449689
93SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.10903428
94KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.10261681
95HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.09972846
96SOX17_20123909_ChIP-Seq_XEN_Mouse1.09528184
97FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.09164415
98SOX9_24532713_ChIP-Seq_HFSC_Mouse1.08596418
99* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.07255007
100ELK1_22589737_ChIP-Seq_MCF10A_Human1.06991577
101P63_26484246_Chip-Seq_KERATINOCYTES_Human1.05592668
102POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.04752497
103* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.04495114
104UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.04428525
105TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.03980059
106STAT6_21828071_ChIP-Seq_BEAS2B_Human1.03931012
107TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03613988
108* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.03212724
109POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.02295953
110CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.02129204
111KLF5_25053715_ChIP-Seq_YYC3_Human1.01737345
112MYCN_18555785_ChIP-Seq_MESCs_Mouse1.01435393
113TRIM28_21343339_ChIP-Seq_HEK293_Human1.00656810
114RARG_19884340_ChIP-ChIP_MEFs_Mouse1.00369743
115PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.00299323
116KAP1_27257070_Chip-Seq_ESCs_Mouse0.99254390
117CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.98088796
118PPAR_26484153_Chip-Seq_NCI-H1993_Human0.97718139
119* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.96955711
120STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.96910618
121LXR_22158963_ChIP-Seq_LIVER_Mouse0.96863892
122TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.96536754
123TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.95595017
124ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.94481942
125* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.92003932
126EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.91157690
127TP53_22127205_ChIP-Seq_IMR90_Human0.91040867
128MYC_18358816_ChIP-ChIP_MESCs_Mouse0.90276131
129EOMES_21245162_ChIP-Seq_HESCs_Human0.90191822
130TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.90068168
131* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.89931384
132NANOG_21062744_ChIP-ChIP_HESCs_Human0.89930989
133E2F1_21310950_ChIP-Seq_MCF-7_Human0.89708820
134TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.89702495
135MYB_21317192_ChIP-Seq_ERMYB_Mouse0.89496797
136SOX2_20726797_ChIP-Seq_SW620_Human0.88894884
137POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.88854086
138RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88707074
139* CJUN_26792858_Chip-Seq_BT549_Human0.87024578
140CHD1_26751641_Chip-Seq_LNCaP_Human0.85990622
141FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.84834731

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle4.22932493
2MP0010352_gastrointestinal_tract_polyps3.34819310
3MP0003191_abnormal_cellular_cholesterol3.24894988
4MP0002254_reproductive_system_inflammat3.19652849
5MP0004264_abnormal_extraembryonic_tissu3.09107771
6MP0002796_impaired_skin_barrier2.97498426
7MP0003941_abnormal_skin_development2.95458876
8MP0000537_abnormal_urethra_morphology2.58285436
9MP0005360_urolithiasis2.51436448
10MP0003566_abnormal_cell_adhesion2.39171967
11MP0009840_abnormal_foam_cell2.35656878
12MP0004957_abnormal_blastocyst_morpholog2.27855771
13MP0003453_abnormal_keratinocyte_physiol2.23526604
14MP0002098_abnormal_vibrissa_morphology2.19325723
15MP0003693_abnormal_embryo_hatching2.16782544
16MP0003705_abnormal_hypodermis_morpholog2.06151874
17* MP0005501_abnormal_skin_physiology2.05371121
18MP0008057_abnormal_DNA_replication2.03556341
19MP0005451_abnormal_body_composition2.03048015
20MP0010678_abnormal_skin_adnexa2.02444350
21MP0010030_abnormal_orbit_morphology1.94947422
22MP0001849_ear_inflammation1.94778607
23MP0009053_abnormal_anal_canal1.91038923
24MP0002139_abnormal_hepatobiliary_system1.89080014
25MP0000762_abnormal_tongue_morphology1.83743214
26MP0001216_abnormal_epidermal_layer1.78312573
27MP0000467_abnormal_esophagus_morphology1.74606285
28MP0001666_abnormal_nutrient_absorption1.68174471
29MP0000383_abnormal_hair_follicle1.65356641
30MP0003890_abnormal_embryonic-extraembry1.64501867
31MP0002009_preneoplasia1.61655524
32MP0008260_abnormal_autophagy1.59412879
33MP0005076_abnormal_cell_differentiation1.58395954
34MP0002060_abnormal_skin_morphology1.58065883
35MP0000490_abnormal_crypts_of1.56792461
36MP0005409_darkened_coat_color1.53504105
37MP0000566_synostosis1.48672382
38MP0005377_hearing/vestibular/ear_phenot1.48117167
39MP0003878_abnormal_ear_physiology1.48117167
40MP0003806_abnormal_nucleotide_metabolis1.47913310
41MP0004782_abnormal_surfactant_physiolog1.45453393
42MP0003077_abnormal_cell_cycle1.45306354
43MP0002877_abnormal_melanocyte_morpholog1.44194917
44MP0003111_abnormal_nucleus_morphology1.41456786
45MP0004133_heterotaxia1.40148511
46MP0000516_abnormal_urinary_system1.39685829
47MP0005367_renal/urinary_system_phenotyp1.39685829
48MP0000579_abnormal_nail_morphology1.38515311
49MP0005023_abnormal_wound_healing1.38030274
50MP0000350_abnormal_cell_proliferation1.35599830
51MP0005257_abnormal_intraocular_pressure1.35278014
52MP0003119_abnormal_digestive_system1.34680213
53MP0005275_abnormal_skin_tensile1.33082205
54MP0002086_abnormal_extraembryonic_tissu1.31206573
55MP0003300_gastrointestinal_ulcer1.31112192
56MP0009697_abnormal_copulation1.30708731
57MP0000377_abnormal_hair_follicle1.29005859
58MP0002084_abnormal_developmental_patter1.26901832
59MP0008007_abnormal_cellular_replicative1.25589508
60MP0001346_abnormal_lacrimal_gland1.25184304
61MP0010094_abnormal_chromosome_stability1.22615880
62MP0000477_abnormal_intestine_morphology1.20881652
63MP0004858_abnormal_nervous_system1.20628700
64MP0002085_abnormal_embryonic_tissue1.18903395
65MP0001672_abnormal_embryogenesis/_devel1.18116834
66MP0005380_embryogenesis_phenotype1.18116834
67MP0008789_abnormal_olfactory_epithelium1.17628677
68MP0000627_abnormal_mammary_gland1.17338519
69MP0010155_abnormal_intestine_physiology1.16429868
70MP0002653_abnormal_ependyma_morphology1.16393968
71MP0000858_altered_metastatic_potential1.15766481
72MP0003718_maternal_effect1.13853740
73MP0004947_skin_inflammation1.13846070
74MP0003786_premature_aging1.13483195
75MP0001730_embryonic_growth_arrest1.12482575
76MP0003315_abnormal_perineum_morphology1.12187123
77MP0004197_abnormal_fetal_growth/weight/1.11192749
78MP0000470_abnormal_stomach_morphology1.10939915
79MP0010368_abnormal_lymphatic_system1.10519205
80MP0000678_abnormal_parathyroid_gland1.10449681
81MP0002111_abnormal_tail_morphology1.08313998
82MP0003937_abnormal_limbs/digits/tail_de1.05907258
83* MP0005085_abnormal_gallbladder_physiolo1.05599106
84MP0002277_abnormal_respiratory_mucosa1.05077353
85MP0005365_abnormal_bile_salt1.03475329
86* MP0010771_integument_phenotype1.02256424
87MP0003091_abnormal_cell_migration1.01522433
88MP0003984_embryonic_growth_retardation1.01201726
89MP0002088_abnormal_embryonic_growth/wei1.00825984
90MP0003868_abnormal_feces_composition1.00495463
91MP0000462_abnormal_digestive_system0.99592601
92MP0005394_taste/olfaction_phenotype0.98881921
93MP0005499_abnormal_olfactory_system0.98881921
94MP0003866_abnormal_defecation0.98690435
95MP0001293_anophthalmia0.96150135
96MP0000432_abnormal_head_morphology0.95847726
97MP0003763_abnormal_thymus_physiology0.94428857
98MP0009780_abnormal_chondrocyte_physiolo0.94041154
99MP0008004_abnormal_stomach_pH0.93869662
100MP0001697_abnormal_embryo_size0.92233296
101MP0003950_abnormal_plasma_membrane0.91383257
102MP0003283_abnormal_digestive_organ0.89220870
103MP0010307_abnormal_tumor_latency0.89007133
104MP0008058_abnormal_DNA_repair0.88848710
105MP0005164_abnormal_response_to0.88033540
106MP0001286_abnormal_eye_development0.87587410
107MP0001881_abnormal_mammary_gland0.87162451
108MP0005248_abnormal_Harderian_gland0.86910009
109MP0004185_abnormal_adipocyte_glucose0.86693558
110MP0003936_abnormal_reproductive_system0.86456304
111MP0003252_abnormal_bile_duct0.85588352
112MP0002697_abnormal_eye_size0.85509631
113MP0001191_abnormal_skin_condition0.85061869
114MP0008932_abnormal_embryonic_tissue0.84379597
115MP0009931_abnormal_skin_appearance0.84330094
116MP0005670_abnormal_white_adipose0.84017376
117MP0002233_abnormal_nose_morphology0.83375989
118MP0000647_abnormal_sebaceous_gland0.83230946
119MP0005666_abnormal_adipose_tissue0.81622683
120MP0003183_abnormal_peptide_metabolism0.81615299
121MP0002092_abnormal_eye_morphology0.79837272
122MP0000613_abnormal_salivary_gland0.79637176
123MP0003943_abnormal_hepatobiliary_system0.79284953
124MP0006054_spinal_hemorrhage0.77204308
125MP0001873_stomach_inflammation0.77104986
126MP0003755_abnormal_palate_morphology0.76716243
127MP0004233_abnormal_muscle_weight0.76693536
128MP0003329_amyloid_beta_deposits0.76185647
129MP0002089_abnormal_postnatal_growth/wei0.76079639
130MP0004019_abnormal_vitamin_homeostasis0.74873662
131MP0003448_altered_tumor_morphology0.74414116
132MP0004272_abnormal_basement_membrane0.74162225
133MP0001727_abnormal_embryo_implantation0.73751751
134MP0002080_prenatal_lethality0.73520687
135MP0005621_abnormal_cell_physiology0.73449562
136* MP0005165_increased_susceptibility_to0.73360741
137MP0001664_abnormal_digestion0.72101116
138MP0002234_abnormal_pharynx_morphology0.70949303
139MP0009643_abnormal_urine_homeostasis0.67907065

Predicted human phenotypes

RankGene SetZ-score
1Milia (HP:0001056)4.58928903
2Onycholysis (HP:0001806)4.57383802
3Right ventricular cardiomyopathy (HP:0011663)4.51785806
4Pili torti (HP:0003777)3.78176420
5Fragile nails (HP:0001808)3.70546391
6Plantar hyperkeratosis (HP:0007556)3.63024243
7Esophageal atresia (HP:0002032)3.42886074
8Lip pit (HP:0100267)3.35509764
9Woolly hair (HP:0002224)3.30131429
10Short nail (HP:0001799)3.16148001
11Atrophic scars (HP:0001075)3.15289458
12Nail dystrophy (HP:0008404)3.10286505
13Curly hair (HP:0002212)3.01653530
14Conjugated hyperbilirubinemia (HP:0002908)3.00412825
15Abnormality of carpal bone ossification (HP:0006257)2.97426865
16Vascular calcification (HP:0004934)2.86414802
17Short humerus (HP:0005792)2.84420811
18Aplasia/hypoplasia of the humerus (HP:0006507)2.77288750
19Biliary tract neoplasm (HP:0100574)2.75461681
20Abnormal tarsal ossification (HP:0008369)2.74638418
21Focal segmental glomerulosclerosis (HP:0000097)2.71352463
22Trismus (HP:0000211)2.69656776
23Ependymoma (HP:0002888)2.67972413
24Fragile skin (HP:0001030)2.66622032
25Thick nail (HP:0001805)2.65480324
26Arterial tortuosity (HP:0005116)2.64365593
27Amyloidosis (HP:0011034)2.63235305
28Abnormal foot bone ossification (HP:0010675)2.55109756
29Palmar hyperkeratosis (HP:0010765)2.54115368
30Missing ribs (HP:0000921)2.53990723
31Abnormality of nail color (HP:0100643)2.53963312
32Abnormal hemoglobin (HP:0011902)2.52117108
33Hypotrichosis (HP:0001006)2.50431256
34Palmoplantar hyperkeratosis (HP:0000972)2.50255414
35Pustule (HP:0200039)2.50090256
36Alopecia of scalp (HP:0002293)2.48835124
37Absent radius (HP:0003974)2.48563757
38Hyperactive renin-angiotensin system (HP:0000841)2.48401748
39Cardiovascular calcification (HP:0011915)2.46653652
40Selective tooth agenesis (HP:0001592)2.46639759
41Abnormal ossification of hand bones (HP:0005921)2.45872686
42Osteolytic defects of the hand bones (HP:0009699)2.43663876
43Osteolytic defects of the phalanges of the hand (HP:0009771)2.43663876
44Blepharitis (HP:0000498)2.39474694
45Ankyloglossia (HP:0010296)2.38248712
46Rib fusion (HP:0000902)2.38157898
47Gastrointestinal atresia (HP:0002589)2.37824305
48Premature rupture of membranes (HP:0001788)2.35661317
49Hypoplastic labia majora (HP:0000059)2.35052654
50Aplasia involving forearm bones (HP:0009822)2.34801922
51Absent forearm bone (HP:0003953)2.34801922
52Micronodular cirrhosis (HP:0001413)2.33876865
53Subacute progressive viral hepatitis (HP:0006572)2.32955373
54Vertebral hypoplasia (HP:0008417)2.32014570
55Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.32014570
56Abnormality of the salivary glands (HP:0010286)2.29115146
57Gastrointestinal carcinoma (HP:0002672)2.29062904
58Malignant gastrointestinal tract tumors (HP:0006749)2.29062904
59Vertebral clefting (HP:0008428)2.29026695
60Abnormality of chloride homeostasis (HP:0011422)2.28459129
61Cervical subluxation (HP:0003308)2.28454104
62Abnormality of oral frenula (HP:0000190)2.27596056
63Deviation of the thumb (HP:0009603)2.25562064
64Cheilitis (HP:0100825)2.24552109
65Abnormality of the gastric mucosa (HP:0004295)2.23992050
66Fused cervical vertebrae (HP:0002949)2.23951038
67Abnormality of glutamine family amino acid metabolism (HP:0010902)2.22995314
68Abnormality of the common coagulation pathway (HP:0010990)2.20369349
69Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.18854902
70Abnormal blistering of the skin (HP:0008066)2.18788801
71Abnormality of the nasal septum (HP:0000419)2.16624280
72Abnormal hair laboratory examination (HP:0003328)2.16143725
73Abnormality of monocarboxylic acid metabolism (HP:0010996)2.15901304
74Glomerulosclerosis (HP:0000096)2.14476586
75Hypoplasia of dental enamel (HP:0006297)2.14071549
76Abnormal hand bone ossification (HP:0010660)2.13163473
77Reduced subcutaneous adipose tissue (HP:0003758)2.12913628
78Ridged nail (HP:0001807)2.12840464
79Colon cancer (HP:0003003)2.12505596
80Distal lower limb muscle weakness (HP:0009053)2.11322880
81Chromosomal breakage induced by crosslinking agents (HP:0003221)2.10903899
82Astrocytoma (HP:0009592)2.09434082
83Abnormality of the astrocytes (HP:0100707)2.09434082
84Abnormality of the labia majora (HP:0012881)2.09192619
85Abnormality of the distal phalanges of the toes (HP:0010182)2.08348834
86Stenosis of the external auditory canal (HP:0000402)2.07624458
87Chromsome breakage (HP:0040012)2.07431416
88Pterygium (HP:0001059)2.07149922
89Malnutrition (HP:0004395)2.05986530
90Proximal placement of thumb (HP:0009623)2.05276184
91Spinal cord compression (HP:0002176)2.03351528
92Reticulocytopenia (HP:0001896)2.03208354
93Sparse scalp hair (HP:0002209)2.03136913
94Broad face (HP:0000283)2.02928974
95Anal stenosis (HP:0002025)2.02665819
96Aplasia cutis congenita (HP:0001057)2.02578991
97Fat malabsorption (HP:0002630)2.01945550
98Vascular tortuosity (HP:0004948)2.01792514
99Flattened epiphyses (HP:0003071)2.01539001
10011 pairs of ribs (HP:0000878)2.01515746
101Renal salt wasting (HP:0000127)2.01022609
102Rectal prolapse (HP:0002035)1.97837211
103Abnormal vertebral ossification (HP:0100569)1.96130654
104Popliteal pterygium (HP:0009756)1.94258649
105Hypobetalipoproteinemia (HP:0003563)1.93924499
106Intrahepatic cholestasis (HP:0001406)1.93810017
107Uterine neoplasm (HP:0010784)1.93651174
108Abnormality of the distal phalanx of the thumb (HP:0009617)1.93548429
109Natal tooth (HP:0000695)1.93417927
110Abnormality of the labia minora (HP:0012880)1.92226071
111Hypolipoproteinemia (HP:0010981)1.89672736
112Distal lower limb amyotrophy (HP:0008944)1.88923856
113Late onset (HP:0003584)1.87797373
114Abnormal biliary tract morphology (HP:0012440)1.87520719
115Advanced eruption of teeth (HP:0006288)1.87342486
116Aplasia/Hypoplasia of the spleen (HP:0010451)1.82089215
117Sparse eyelashes (HP:0000653)1.81919733
118Poikiloderma (HP:0001029)1.79499532
119Abnormality of proline metabolism (HP:0010907)1.79458978
120Hydroxyprolinuria (HP:0003080)1.79458978
121Hemorrhage of the eye (HP:0011885)1.79069843
122Rhabdomyosarcoma (HP:0002859)1.79014929
123Absent thumb (HP:0009777)1.78023279
124Ectopic kidney (HP:0000086)1.77916830
125Palpitations (HP:0001962)1.77663439
126Insulin resistance (HP:0000855)1.77379096
127Abnormality of abdominal situs (HP:0011620)1.76989622
128Abdominal situs inversus (HP:0003363)1.76989622
129Dehydration (HP:0001944)1.76832076
130Neonatal death (HP:0003811)1.76195717
131Ureteral stenosis (HP:0000071)1.75948994
132Congenital ichthyosiform erythroderma (HP:0007431)1.75615412
133Glucose intolerance (HP:0000833)1.75172221
134Abnormal delivery (HP:0001787)1.74716314
135Abdominal distention (HP:0003270)1.73975651
136Vertebral compression fractures (HP:0002953)1.72560990
137Oligodontia (HP:0000677)1.72434556
138Abnormality of the preputium (HP:0100587)1.72327192
139Flat acetabular roof (HP:0003180)1.72080836
140Hepatocellular carcinoma (HP:0001402)1.72019244
141Acanthosis nigricans (HP:0000956)1.71609502
142Back pain (HP:0003418)1.71586015
143Ileus (HP:0002595)1.71442718
144Asplenia (HP:0001746)1.71346231
145Unilateral renal agenesis (HP:0000122)1.70102258
146Neoplasm of the oral cavity (HP:0100649)1.69199543
147Abnormalities of placenta or umbilical cord (HP:0001194)1.68972993
148Ureteral obstruction (HP:0006000)1.68741149
149Abnormality of the umbilical cord (HP:0010881)1.68636155
150Ectropion (HP:0000656)1.68403542
151Microretrognathia (HP:0000308)1.68319989
152Vertebral fusion (HP:0002948)1.67649312
153Anonychia (HP:0001798)1.67167055
154Abnormality of the fetal cardiovascular system (HP:0010948)1.66864150
155Abnormal umbilical cord blood vessels (HP:0011403)1.66864150
156Single umbilical artery (HP:0001195)1.66864150
157Metabolic alkalosis (HP:0200114)1.66840167
158Volvulus (HP:0002580)1.66744558
159Abnormality of the acetabulum (HP:0003170)1.66558944
160Hypoalphalipoproteinemia (HP:0003233)1.65340471
161Abnormal glucose tolerance (HP:0001952)1.65209195
162Glioma (HP:0009733)1.63637088
163Basal cell carcinoma (HP:0002671)1.63001687
164Stomach cancer (HP:0012126)1.61917100

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA28.03387577
2MST44.76450299
3LMTK24.33357038
4CDK123.36932545
5RPS6KB22.98004094
6STK102.48000821
7STK38L2.24838564
8PBK2.19446768
9TESK22.15491322
10MAP3K32.14897766
11NME22.12496375
12LATS12.11771814
13ERN12.03651870
14MAP3K122.00007261
15SMG11.88386526
16IRAK31.80568063
17MET1.74129186
18TTK1.71896477
19MST1R1.63159466
20BUB11.58661209
21SIK11.46027109
22TRIB31.44796225
23EPHB21.44751459
24FER1.43542942
25PAK41.38558254
26MAP2K21.36330414
27RIPK11.35829452
28PRKCI1.33843254
29MAP3K21.32743664
30CDK71.26660177
31VRK21.24559602
32EIF2AK11.22758514
33SCYL21.22673632
34FRK1.21184187
35MAPKAPK31.19676599
36CDK61.17540638
37PTK21.17419394
38TSSK61.17035411
39EEF2K1.14247316
40AKT31.08372105
41MAPK151.08114052
42MAP3K81.06103295
43BMX1.04553955
44GRK61.04509777
45LIMK11.03755694
46NUAK11.03536564
47AURKB1.00052540
48LRRK20.99478559
49DDR20.92968390
50PASK0.90936839
51MAP3K140.90899860
52STK390.90096545
53PIM10.87677673
54ARAF0.87659374
55PTK60.87191556
56WNK30.83866948
57TRPM70.80245193
58PRKG20.79696597
59CHUK0.79308662
60CDK80.78806893
61FLT30.77602675
62RPS6KA40.76686179
63TAOK20.74550670
64CDK90.74302585
65STK30.74207141
66ALK0.73426300
67DMPK0.73166192
68PLK10.72631861
69MAP3K100.72552341
70NLK0.72336382
71FGFR40.71838201
72CSK0.71295042
73TESK10.71166154
74MAP3K110.71054185
75NEK20.70215151
76BRD40.70083631
77PIM20.69996004
78MTOR0.69329563
79CDC70.69272370
80MELK0.67977360
81WEE10.66675310
82CHEK10.66587639
83ZAK0.65785493
84TAF10.64542718
85DAPK10.63326394
86ILK0.63129729
87CDK40.62297778
88TYRO30.62108588
89PDGFRA0.62079482
90NTRK10.61679942
91TGFBR10.60948991
92MAP2K30.60198546
93NEK10.60166731
94DYRK1B0.59030737
95CHEK20.58504283
96ERBB40.57695369
97TTN0.57005014
98MAP3K60.56222999
99ERBB30.55806699
100PKN20.55717673
101DYRK30.55249740
102EPHB10.54689314
103ACVR1B0.54136277
104EIF2AK30.53410842
105AKT20.51011236
106PHKG20.50973469
107PHKG10.50973469
108TAOK10.50878147
109MATK0.50353802
110ABL20.50339236
111PTK2B0.48386921
112ATR0.48258369
113ICK0.47209599
114FGFR10.45521761
115PDGFRB0.45410335
116STK40.45204966
117BRSK20.44956636
118ROCK20.44807147
119ITK0.44276984
120ATM0.43565902
121EIF2AK20.43361165
122ERBB20.43216303
123YES10.43015995
124LATS20.42461353
125SRPK10.42402026
126MAP3K70.40280515
127GSK3A0.39659336
128SIK30.38830253
129BRAF0.38604809
130IKBKB0.36603603
131MAPKAPK20.36470580
132EPHA30.36431864
133MAP3K10.36388220
134CDK20.36233888
135BRSK10.35382232
136PLK30.35188815
137JAK30.34918402
138CSNK1E0.33601715
139FGR0.32954839
140STK380.32818452
141FGFR30.32308422
142PDK20.28662637
143BCR0.26906961
144TGFBR20.25632221
145STK240.23513928
146KDR0.21691587
147PRPF4B0.19017790
148KSR10.18387806
149AURKA0.17694811

Predicted pathways (KEGG)

RankGene SetZ-score
1Adherens junction_Homo sapiens_hsa045202.73368179
2Sulfur metabolism_Homo sapiens_hsa009202.47290023
3Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.37617134
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.33490942
5Mismatch repair_Homo sapiens_hsa034302.29746632
6Hippo signaling pathway_Homo sapiens_hsa043902.17453475
7Tight junction_Homo sapiens_hsa045302.01623609
8p53 signaling pathway_Homo sapiens_hsa041151.92888008
9Basal cell carcinoma_Homo sapiens_hsa052171.89336467
10Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.87482524
11RNA transport_Homo sapiens_hsa030131.85210361
122-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.82250140
13Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.80985176
14Ribosome_Homo sapiens_hsa030101.80263110
15Small cell lung cancer_Homo sapiens_hsa052221.73533903
16Starch and sucrose metabolism_Homo sapiens_hsa005001.72540722
17DNA replication_Homo sapiens_hsa030301.72228338
18Bladder cancer_Homo sapiens_hsa052191.70988819
19Thyroid cancer_Homo sapiens_hsa052161.70918696
20Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.69322535
21One carbon pool by folate_Homo sapiens_hsa006701.68063701
22Mineral absorption_Homo sapiens_hsa049781.63589340
23Drug metabolism - other enzymes_Homo sapiens_hsa009831.62597565
24Spliceosome_Homo sapiens_hsa030401.61199496
25Proteasome_Homo sapiens_hsa030501.59776377
26Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.58596926
27Pentose phosphate pathway_Homo sapiens_hsa000301.54948866
28Leukocyte transendothelial migration_Homo sapiens_hsa046701.52988534
29Arginine biosynthesis_Homo sapiens_hsa002201.52476050
30Biosynthesis of amino acids_Homo sapiens_hsa012301.49314736
31MicroRNAs in cancer_Homo sapiens_hsa052061.41076338
32Cell cycle_Homo sapiens_hsa041101.38242004
33Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.36780681
34N-Glycan biosynthesis_Homo sapiens_hsa005101.31659993
35Notch signaling pathway_Homo sapiens_hsa043301.30710046
36ECM-receptor interaction_Homo sapiens_hsa045121.28419346
37Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.28285793
38Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.27341545
39Fatty acid elongation_Homo sapiens_hsa000621.25679985
40mRNA surveillance pathway_Homo sapiens_hsa030151.21904961
41Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.19403717
42TGF-beta signaling pathway_Homo sapiens_hsa043501.18218494
43Central carbon metabolism in cancer_Homo sapiens_hsa052301.17365117
44Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.15045099
45Proteoglycans in cancer_Homo sapiens_hsa052051.14841639
46Antigen processing and presentation_Homo sapiens_hsa046121.14762864
47NF-kappa B signaling pathway_Homo sapiens_hsa040641.14556514
48Carbon metabolism_Homo sapiens_hsa012001.14531020
49Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.12242941
50Fatty acid biosynthesis_Homo sapiens_hsa000611.10980477
51Sphingolipid metabolism_Homo sapiens_hsa006001.09643686
52Steroid biosynthesis_Homo sapiens_hsa001001.08518209
53Homologous recombination_Homo sapiens_hsa034401.07867268
54Base excision repair_Homo sapiens_hsa034101.07583563
55Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.06382193
56Legionellosis_Homo sapiens_hsa051341.05575681
57Fanconi anemia pathway_Homo sapiens_hsa034601.04979704
58Viral carcinogenesis_Homo sapiens_hsa052031.04461675
59NOD-like receptor signaling pathway_Homo sapiens_hsa046211.04395118
60Other glycan degradation_Homo sapiens_hsa005111.03610428
61Hedgehog signaling pathway_Homo sapiens_hsa043401.03030450
62Toxoplasmosis_Homo sapiens_hsa051451.01702596
63Transcriptional misregulation in cancer_Homo sapiens_hsa052021.01541268
64Herpes simplex infection_Homo sapiens_hsa051681.00671226
65Endometrial cancer_Homo sapiens_hsa052130.98743497
66HTLV-I infection_Homo sapiens_hsa051660.98273654
67Pentose and glucuronate interconversions_Homo sapiens_hsa000400.98051313
68Pathways in cancer_Homo sapiens_hsa052000.96197793
69Renin-angiotensin system_Homo sapiens_hsa046140.95763317
70Pancreatic cancer_Homo sapiens_hsa052120.95460631
71Glutathione metabolism_Homo sapiens_hsa004800.95130429
72Arginine and proline metabolism_Homo sapiens_hsa003300.94990757
73Nucleotide excision repair_Homo sapiens_hsa034200.93091469
74Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.92605636
75Retinol metabolism_Homo sapiens_hsa008300.92234274
76Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.92140239
77Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.91906047
78Apoptosis_Homo sapiens_hsa042100.91365970
79TNF signaling pathway_Homo sapiens_hsa046680.90491979
80Pyruvate metabolism_Homo sapiens_hsa006200.90293348
81Regulation of actin cytoskeleton_Homo sapiens_hsa048100.89713418
82Cyanoamino acid metabolism_Homo sapiens_hsa004600.89689449
83Caffeine metabolism_Homo sapiens_hsa002320.89617894
84Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.89097567
85Non-homologous end-joining_Homo sapiens_hsa034500.88854112
86RNA degradation_Homo sapiens_hsa030180.88062399
87Steroid hormone biosynthesis_Homo sapiens_hsa001400.86173085
88Pyrimidine metabolism_Homo sapiens_hsa002400.84549976
89Wnt signaling pathway_Homo sapiens_hsa043100.84257340
90Prostate cancer_Homo sapiens_hsa052150.84006353
91Sulfur relay system_Homo sapiens_hsa041220.83450770
92Fatty acid metabolism_Homo sapiens_hsa012120.82745414
93Focal adhesion_Homo sapiens_hsa045100.82683955
94Intestinal immune network for IgA production_Homo sapiens_hsa046720.80763393
95Hematopoietic cell lineage_Homo sapiens_hsa046400.78356773
96Arachidonic acid metabolism_Homo sapiens_hsa005900.78207088
97Hepatitis C_Homo sapiens_hsa051600.78203822
98PPAR signaling pathway_Homo sapiens_hsa033200.78183413
99Cysteine and methionine metabolism_Homo sapiens_hsa002700.77039025
100Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.75687523
101alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.75459559
102Linoleic acid metabolism_Homo sapiens_hsa005910.74835097
103Chemical carcinogenesis_Homo sapiens_hsa052040.74532951
104Melanoma_Homo sapiens_hsa052180.74200567
105Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.74184139
106Bile secretion_Homo sapiens_hsa049760.73665955
107Colorectal cancer_Homo sapiens_hsa052100.72262150
108Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.71094033
109Vibrio cholerae infection_Homo sapiens_hsa051100.70017128
110Vitamin digestion and absorption_Homo sapiens_hsa049770.68801123
111Chronic myeloid leukemia_Homo sapiens_hsa052200.67902753
112RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.67861740
113Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.67641284
114Phenylalanine metabolism_Homo sapiens_hsa003600.67397081
115Shigellosis_Homo sapiens_hsa051310.67289884
116Epstein-Barr virus infection_Homo sapiens_hsa051690.67051104
117Fatty acid degradation_Homo sapiens_hsa000710.67006760
118RNA polymerase_Homo sapiens_hsa030200.66968122
119Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.66886795
120Influenza A_Homo sapiens_hsa051640.66848711
121Acute myeloid leukemia_Homo sapiens_hsa052210.66812044
122Histidine metabolism_Homo sapiens_hsa003400.66337733
123Fat digestion and absorption_Homo sapiens_hsa049750.64977604
124Leishmaniasis_Homo sapiens_hsa051400.64966907
125Galactose metabolism_Homo sapiens_hsa000520.64352142
126Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.63702152
127Amoebiasis_Homo sapiens_hsa051460.63225698
128Protein digestion and absorption_Homo sapiens_hsa049740.63161466
129Salmonella infection_Homo sapiens_hsa051320.61190625
130Primary immunodeficiency_Homo sapiens_hsa053400.60962979
131Endocytosis_Homo sapiens_hsa041440.59853933
132Fructose and mannose metabolism_Homo sapiens_hsa000510.59699604
133Selenocompound metabolism_Homo sapiens_hsa004500.59244554
134Basal transcription factors_Homo sapiens_hsa030220.58682671
135Measles_Homo sapiens_hsa051620.57297603
136Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.55336562
137Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.55325726
138Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.55317466
139Complement and coagulation cascades_Homo sapiens_hsa046100.55017825
140Viral myocarditis_Homo sapiens_hsa054160.54381434
141Folate biosynthesis_Homo sapiens_hsa007900.53963485
142Rap1 signaling pathway_Homo sapiens_hsa040150.51923403
143PI3K-Akt signaling pathway_Homo sapiens_hsa041510.51106020
144Maturity onset diabetes of the young_Homo sapiens_hsa049500.49646033
145Pancreatic secretion_Homo sapiens_hsa049720.47688725
146Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.45052290
147Metabolic pathways_Homo sapiens_hsa011000.36057664

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