F2RL2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the protease-activated receptor (PAR) family which is a subfamily of the seven transmembrane G protein-coupled cell surface receptor family. The encoded protein acts as a cofactor in the thrombin-mediated cleavage and activation of the protease-activated receptor family member PAR4. The encoded protein plays an essential role in hemostasis and thrombosis. Alternate splicing results in multiple transcript variants that encode different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1endothelium development (GO:0003158)6.21657104
2peripheral nervous system neuron development (GO:0048935)6.21001954
3vascular endothelial growth factor signaling pathway (GO:0038084)6.03031174
4chondrocyte proliferation (GO:0035988)5.79910995
5sprouting angiogenesis (GO:0002040)5.68364936
6negative regulation of calcium ion transport into cytosol (GO:0010523)5.44149353
7detection of temperature stimulus involved in sensory perception of pain (GO:0050965)5.31707038
8detection of temperature stimulus involved in sensory perception (GO:0050961)5.31707038
9blood vessel maturation (GO:0001955)5.04998798
10basement membrane organization (GO:0071711)5.01633534
11histamine secretion (GO:0001821)4.96695684
12retina vasculature morphogenesis in camera-type eye (GO:0061299)4.80490246
13ether lipid metabolic process (GO:0046485)4.70994388
14* thrombin receptor signaling pathway (GO:0070493)4.69553825
15detection of temperature stimulus (GO:0016048)4.65472187
16collagen fibril organization (GO:0030199)4.52169488
17wound healing, spreading of epidermal cells (GO:0035313)4.46355505
18positive regulation of macrophage differentiation (GO:0045651)4.45628303
19sequestering of extracellular ligand from receptor (GO:0035581)4.44016500
20negative regulation of dendrite morphogenesis (GO:0050774)4.38901425
21negative regulation of cytosolic calcium ion concentration (GO:0051481)4.37724886
22lymphangiogenesis (GO:0001946)4.30499624
23keratan sulfate catabolic process (GO:0042340)4.26467405
24cellular response to ATP (GO:0071318)4.22862030
25smooth muscle tissue development (GO:0048745)4.22363173
26endodermal cell differentiation (GO:0035987)4.22240701
27histamine transport (GO:0051608)4.19356860
28lymph vessel development (GO:0001945)4.18439803
29positive regulation of vasculogenesis (GO:2001214)4.18161984
30cell migration involved in sprouting angiogenesis (GO:0002042)4.08463450
31respiratory burst (GO:0045730)4.07750242
32glomerular basement membrane development (GO:0032836)4.04382682
33regulation of vasculogenesis (GO:2001212)3.93524507
34antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.91756597
35negative regulation of type 2 immune response (GO:0002829)3.88995934
36adenosine metabolic process (GO:0046085)3.86691909
37regulation of platelet aggregation (GO:0090330)3.79179167
38positive regulation of cardiac muscle cell differentiation (GO:2000727)3.77299824
39cellular response to exogenous dsRNA (GO:0071360)3.74795915
40Arp2/3 complex-mediated actin nucleation (GO:0034314)3.74534470
41angiogenesis involved in wound healing (GO:0060055)3.74194004
42platelet dense granule organization (GO:0060155)3.73570989
43cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.70522734
44vascular endothelial growth factor receptor signaling pathway (GO:0048010)3.70449671
45type B pancreatic cell proliferation (GO:0044342)3.67072144
46regulation of alpha-beta T cell proliferation (GO:0046640)3.66502026
47negative regulation of homotypic cell-cell adhesion (GO:0034111)3.66409626
48Notch signaling involved in heart development (GO:0061314)3.65555892
49positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-3.64980687
50protein heterotrimerization (GO:0070208)3.60108176
51behavioral response to pain (GO:0048266)3.57828697
52positive regulation of gamma-delta T cell activation (GO:0046645)3.56479218
53positive regulation of alpha-beta T cell proliferation (GO:0046641)3.55602748
54substrate adhesion-dependent cell spreading (GO:0034446)3.52669539
55actin nucleation (GO:0045010)3.51296256
56negative regulation of axon extension involved in axon guidance (GO:0048843)3.50125475
57interferon-gamma production (GO:0032609)3.48304312
58modulation by symbiont of host defense response (GO:0052031)3.47180925
59modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.47180925
60modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.47180925
61positive regulation by organism of defense response of other organism involved in symbiotic interact3.47180925
62modulation by symbiont of host immune response (GO:0052553)3.47180925
63positive regulation by symbiont of host defense response (GO:0052509)3.47180925
64substrate-dependent cell migration (GO:0006929)3.46925716
65negative regulation of cAMP-mediated signaling (GO:0043951)3.46087290
66leukocyte aggregation (GO:0070486)3.45179078
67mesodermal cell differentiation (GO:0048333)3.44567069
68negative regulation of protein autophosphorylation (GO:0031953)3.42475934
69negative regulation of nitric oxide biosynthetic process (GO:0045019)3.42002846
70collagen metabolic process (GO:0032963)3.40724719
71endothelial cell proliferation (GO:0001935)3.40650497
72regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.39235010
73neuronal action potential (GO:0019228)3.38964418
74bone trabecula formation (GO:0060346)3.37072845
75cell adhesion mediated by integrin (GO:0033627)3.34733318
76collagen catabolic process (GO:0030574)3.33218340
77phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.31708499
78positive regulation of Rho protein signal transduction (GO:0035025)3.30738088
79mast cell activation (GO:0045576)3.28701756
80response to peptidoglycan (GO:0032494)3.28653347
81response to pain (GO:0048265)3.27988201
82cellular response to interferon-beta (GO:0035458)3.20738609
83heparin biosynthetic process (GO:0030210)3.20271895
84heparin metabolic process (GO:0030202)3.20271895
85G-protein coupled receptor internalization (GO:0002031)3.19841590
86negative regulation of T cell mediated immunity (GO:0002710)3.17671360
87mesenchymal-epithelial cell signaling (GO:0060638)3.17387540
88endocardial cushion development (GO:0003197)3.16728728
89definitive hemopoiesis (GO:0060216)3.16049883
90natural killer cell activation involved in immune response (GO:0002323)3.13998695
91regulation of interleukin-8 secretion (GO:2000482)3.13794709
92serotonin receptor signaling pathway (GO:0007210)3.10445258
93production of molecular mediator involved in inflammatory response (GO:0002532)3.09925402
94multicellular organismal macromolecule metabolic process (GO:0044259)3.08156653
95patterning of blood vessels (GO:0001569)3.07521818
96dermatan sulfate biosynthetic process (GO:0030208)3.07243610
97glomerular visceral epithelial cell development (GO:0072015)3.05908752
98negative regulation of calcium ion-dependent exocytosis (GO:0045955)3.05596174
99cellular response to interleukin-15 (GO:0071350)3.04816288
100negative regulation of heart rate (GO:0010459)3.03712038
101endothelial tube morphogenesis (GO:0061154)3.03419763
102morphogenesis of an endothelium (GO:0003159)3.03419763
103tyrosine phosphorylation of STAT protein (GO:0007260)3.03072688
104ventricular septum development (GO:0003281)3.02718544
105positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.02383569
106adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.01610578
107multicellular organismal catabolic process (GO:0044243)3.01567858
108response to ATP (GO:0033198)3.01552552
109regulation of B cell receptor signaling pathway (GO:0050855)3.01111754
110neutrophil activation involved in immune response (GO:0002283)3.00227290
111kidney mesenchyme development (GO:0072074)2.99925452
112heart valve formation (GO:0003188)2.99760774
113positive regulation of interleukin-8 secretion (GO:2000484)2.97743977
114gap junction assembly (GO:0016264)2.97475233
115regulation of activation of Janus kinase activity (GO:0010533)2.96094042
116negative regulation of lymphocyte mediated immunity (GO:0002707)2.95570272
117wound healing, spreading of cells (GO:0044319)2.94712275
118negative regulation of chondrocyte differentiation (GO:0032331)2.94672448
119skin morphogenesis (GO:0043589)2.94297312
120ventricular trabecula myocardium morphogenesis (GO:0003222)2.93787936
121chondrocyte development (GO:0002063)2.92812288
122multicellular organismal metabolic process (GO:0044236)2.91661144
123positive regulation of B cell differentiation (GO:0045579)2.90740508
124positive regulation of T cell mediated cytotoxicity (GO:0001916)2.90270950
125negative regulation of cell killing (GO:0031342)2.90208290
126negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.90208290
127heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.88802175
128regulation of glomerular filtration (GO:0003093)2.88787416
129positive regulation of cellular amide metabolic process (GO:0034250)2.87897985
130behavioral response to ethanol (GO:0048149)2.87856631
131face morphogenesis (GO:0060325)2.87531643
132positive regulation of T-helper 1 type immune response (GO:0002827)2.87385399
133dermatan sulfate metabolic process (GO:0030205)2.86901035
134regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.86869763
135T cell migration (GO:0072678)2.86278590
136response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.86152853
137response to host immune response (GO:0052572)2.86152853
138artery morphogenesis (GO:0048844)2.85758732
139artery development (GO:0060840)2.84551274
140atrial cardiac muscle cell action potential (GO:0086014)2.82977827
141negative regulation of axon guidance (GO:1902668)2.82938780
142blood vessel morphogenesis (GO:0048514)2.82754347
1432-deoxyribonucleotide biosynthetic process (GO:0009265)2.82010787
144deoxyribose phosphate biosynthetic process (GO:0046385)2.82010787
145positive regulation of collagen biosynthetic process (GO:0032967)2.80937582
146regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.80594910
147regulation of cardiac muscle cell differentiation (GO:2000725)2.80414069
148regulation of macrophage differentiation (GO:0045649)2.79914552
149cellular response to vitamin (GO:0071295)2.79620946
150extracellular matrix disassembly (GO:0022617)2.77348429
151regulation of homotypic cell-cell adhesion (GO:0034110)2.76015111
152regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.75938853
153negative chemotaxis (GO:0050919)2.75765808
154response to interleukin-15 (GO:0070672)2.74885045
155cellular response to vitamin D (GO:0071305)2.74871822
156cell migration involved in heart development (GO:0060973)2.74700093
157regulation of B cell differentiation (GO:0045577)2.72948466
158regulation of T cell mediated cytotoxicity (GO:0001914)2.71466854
159endothelial cell morphogenesis (GO:0001886)2.69807849
160lung vasculature development (GO:0060426)2.69672697
161leukocyte degranulation (GO:0043299)2.69524211
162positive regulation of interleukin-17 production (GO:0032740)2.69101952
163adult feeding behavior (GO:0008343)2.68907205
164regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.68317967
165extracellular fibril organization (GO:0043206)2.66885602
166cellular extravasation (GO:0045123)2.66717295
167positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.66367992
168glycerol ether metabolic process (GO:0006662)2.66108021
169positive regulation of synaptic transmission, GABAergic (GO:0032230)2.65933392
170cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.65496289
171urinary tract smooth muscle contraction (GO:0014848)2.65241385
172metanephric mesenchyme development (GO:0072075)2.64971048
173trabecula formation (GO:0060343)2.63978546
174interferon-gamma-mediated signaling pathway (GO:0060333)2.63712411
175positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)2.63566854
176immunoglobulin mediated immune response (GO:0016064)2.62825003
177tissue remodeling (GO:0048771)2.60394131
178extracellular matrix assembly (GO:0085029)2.60381114
179positive regulation of collagen metabolic process (GO:0010714)2.60174124
180extracellular matrix organization (GO:0030198)2.59987013
181negative regulation of dendrite development (GO:2000171)2.59511894
182cytokine production involved in immune response (GO:0002367)2.58645920
183regulation of collateral sprouting (GO:0048670)2.56287689
184positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.55926917
185megakaryocyte development (GO:0035855)2.55155996
186regulation of interleukin-17 production (GO:0032660)2.54632622
187microtubule polymerization or depolymerization (GO:0031109)2.53630852
188myeloid cell activation involved in immune response (GO:0002275)2.52934754
189sequestering of actin monomers (GO:0042989)2.52569817
190neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.49280311
191regulation of protein heterodimerization activity (GO:0043497)2.47447189
192positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.46812687
193negative regulation of smooth muscle contraction (GO:0045986)2.46469293
194positive regulation of interferon-alpha production (GO:0032727)2.46366660
195granulocyte activation (GO:0036230)2.45939008
196positive regulation of monocyte chemotaxis (GO:0090026)2.45700744
197leukocyte cell-cell adhesion (GO:0007159)2.44706014
198detection of mechanical stimulus involved in sensory perception (GO:0050974)2.42741971
199activated T cell proliferation (GO:0050798)2.41768517

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.73188580
2IRF8_21731497_ChIP-ChIP_J774_Mouse5.53916090
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.30603790
4IRF8_22096565_ChIP-ChIP_GC-B_Human4.11346826
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.05162700
6TRIM28_21343339_ChIP-Seq_HEK293_Human3.88972270
7* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.80592615
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.63261371
9PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.36289590
10SMAD_19615063_ChIP-ChIP_OVARY_Human3.11170587
11SCL_19346495_ChIP-Seq_HPC-7_Human2.90939965
12STAT4_19710469_ChIP-ChIP_TH1__Mouse2.76681802
13CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.73993958
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.66169751
15IRF8_27001747_Chip-Seq_BMDM_Mouse2.64927489
16WT1_19549856_ChIP-ChIP_CCG9911_Human2.60365785
17RUNX_20019798_ChIP-Seq_JUKART_Human2.59405064
18* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.58568330
19ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.52023858
20BRD4_25478319_ChIP-Seq_HGPS_Human2.51494120
21* LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.47851009
22STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.43949861
23IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.43750953
24* CJUN_26792858_Chip-Seq_BT549_Human2.42857812
25CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.37950798
26EP300_21415370_ChIP-Seq_HL-1_Mouse2.36349936
27SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.35842898
28MYB_21317192_ChIP-Seq_ERMYB_Mouse2.25154159
29CDX2_19796622_ChIP-Seq_MESCs_Mouse2.23005047
30SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.22635201
31TAF15_26573619_Chip-Seq_HEK293_Human2.15899041
32NFE2L2_20460467_ChIP-Seq_MEFs_Mouse2.14965492
33NRF2_20460467_ChIP-Seq_MEFs_Mouse2.14965492
34SALL1_21062744_ChIP-ChIP_HESCs_Human2.13604263
35NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.09197151
36TP53_18474530_ChIP-ChIP_U2OS_Human2.08226910
37ELF1_17652178_ChIP-ChIP_JURKAT_Human2.02427374
38* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.99391606
39TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.98625550
40TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.97629402
41ZNF217_24962896_ChIP-Seq_MCF-7_Human1.91080737
42TP53_16413492_ChIP-PET_HCT116_Human1.90775440
43EED_16625203_ChIP-ChIP_MESCs_Mouse1.88339825
44Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.87960754
45MYB_26560356_Chip-Seq_TH2_Human1.84042605
46SPI1_23127762_ChIP-Seq_K562_Human1.83421651
47RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.78280486
48PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.78165563
49AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.77320260
50NOTCH1_21737748_ChIP-Seq_TLL_Human1.77222386
51* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.76799745
52* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.75785410
53SPI1_23547873_ChIP-Seq_NB4_Human1.74727540
54RBPJ_22232070_ChIP-Seq_NCS_Mouse1.74623317
55RARG_19884340_ChIP-ChIP_MEFs_Mouse1.73293711
56PIAS1_25552417_ChIP-Seq_VCAP_Human1.70937154
57JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.64790175
58PCGF2_27294783_Chip-Seq_NPCs_Mouse1.64704412
59GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.63745143
60SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.62296742
61GATA1_22025678_ChIP-Seq_K562_Human1.61256936
62GATA1_19941827_ChIP-Seq_MEL_Mouse1.60739731
63SALL4_18804426_ChIP-ChIP_XEN_Mouse1.58215802
64TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.54855294
65EZH2_27294783_Chip-Seq_NPCs_Mouse1.54416553
66* RUNX1_22412390_ChIP-Seq_EML_Mouse1.54026430
67E2F7_22180533_ChIP-Seq_HELA_Human1.53910604
68GBX2_23144817_ChIP-Seq_PC3_Human1.52349666
69SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.52226513
70JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.52219627
71FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.52077595
72RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.49481269
73TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.47980664
74MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.47765641
75SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.46812363
76EGR1_19032775_ChIP-ChIP_M12_Human1.46421534
77OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.46412080
78IKZF1_21737484_ChIP-ChIP_HCT116_Human1.45505940
79KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.45239068
80SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.41880095
81SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.41652306
82SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.40839644
83ESR1_20079471_ChIP-ChIP_T-47D_Human1.39588023
84CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.38882530
85VDR_22108803_ChIP-Seq_LS180_Human1.37356016
86ZFP57_27257070_Chip-Seq_ESCs_Mouse1.35322121
87SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.34970253
88PU_27001747_Chip-Seq_BMDM_Mouse1.33352466
89* P300_19829295_ChIP-Seq_ESCs_Human1.32479284
90NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.30808137
91BCAT_22108803_ChIP-Seq_LS180_Human1.30418261
92* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.29856971
93SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28410980
94RXR_22108803_ChIP-Seq_LS180_Human1.26627237
95SUZ12_27294783_Chip-Seq_NPCs_Mouse1.24977258
96KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.22530203
97PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.20432217
98CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.19539959
99BMI1_23680149_ChIP-Seq_NPCS_Mouse1.19201821
100SMAD3_21741376_ChIP-Seq_EPCs_Human1.19115089
101RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.18826568
102PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.18349402
103* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.18032202
104MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.17591432
105CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.17380737
106GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17157451
107AHR_22903824_ChIP-Seq_MCF-7_Human1.16961452
108TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.16949655
109EZH2_18974828_ChIP-Seq_MESCs_Mouse1.16634719
110RNF2_18974828_ChIP-Seq_MESCs_Mouse1.16634719
111CBP_20019798_ChIP-Seq_JUKART_Human1.16476571
112IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.16476571
113STAT3_23295773_ChIP-Seq_U87_Human1.15314819
114FOXM1_26456572_ChIP-Seq_MCF-7_Human1.13843791
115* CDX2_22108803_ChIP-Seq_LS180_Human1.13345880
116MYB_26560356_Chip-Seq_TH1_Human1.13037937
117* SMAD4_21799915_ChIP-Seq_A2780_Human1.12958992
118PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.11906464
119ISL1_27105846_Chip-Seq_CPCs_Mouse1.10289243
120NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.09839169
121TP63_23658742_ChIP-Seq_EP156T_Human1.09128028
122* FLI1_21867929_ChIP-Seq_TH2_Mouse1.08703669
123NR3C1_23031785_ChIP-Seq_PC12_Mouse1.08177420
124RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.08009113
125ARNT_22903824_ChIP-Seq_MCF-7_Human1.07642372
126FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.06117542
127BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.05888493
128SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.05871538
129NANOG_18555785_Chip-Seq_ESCs_Mouse1.05795298
130NFE2_27457419_Chip-Seq_LIVER_Mouse1.05774435
131PPAR_26484153_Chip-Seq_NCI-H1993_Human1.05129660
132GATA3_27048872_Chip-Seq_THYMUS_Human1.04958644
133BRD4_27068464_Chip-Seq_AML-cells_Mouse1.04906407
134VDR_24787735_ChIP-Seq_THP-1_Human1.04884681
135GATA3_26560356_Chip-Seq_TH2_Human1.04805606
136VDR_24763502_ChIP-Seq_THP-1_Human1.04151254
137ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.03923332
138ZNF274_21170338_ChIP-Seq_K562_Hela1.03169585
139CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.02568717
140NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.02442220
141JUN_21703547_ChIP-Seq_K562_Human1.02203573
142VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.02025174
143EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.01849833
144CRX_20693478_ChIP-Seq_RETINA_Mouse1.01713279
145TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.01607092
146MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.00908675
147NR3C1_21868756_ChIP-Seq_MCF10A_Human1.00769136
148MAF_26560356_Chip-Seq_TH1_Human1.00282197
149JARID2_20064375_ChIP-Seq_MESCs_Mouse0.99849527
150* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.99392733
151TP53_20018659_ChIP-ChIP_R1E_Mouse0.99327875
152SOX9_24532713_ChIP-Seq_HFSC_Mouse0.99321022
153HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.99129722
154MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.99023811
155STAT6_21828071_ChIP-Seq_BEAS2B_Human0.98638640
156* AR_25329375_ChIP-Seq_VCAP_Human0.98530134
157* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.98251668
158KDM2B_26808549_Chip-Seq_REH_Human0.97570371
159AR_21572438_ChIP-Seq_LNCaP_Human0.95077561
160* PRDM14_20953172_ChIP-Seq_ESCs_Human0.94578956
161GATA2_22383799_ChIP-Seq_G1ME_Mouse0.94179162
162FLI1_27457419_Chip-Seq_LIVER_Mouse0.93057390
163POU3F2_20337985_ChIP-ChIP_501MEL_Human0.93054703
164EGR1_19374776_ChIP-ChIP_THP-1_Human0.92839298
165IGF1R_20145208_ChIP-Seq_DFB_Human0.91140974
166SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90684978
167PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.89799817
168CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88330494
169SALL4_22934838_ChIP-ChIP_CD34+_Human0.86098252
170* NANOG_19829295_ChIP-Seq_ESCs_Human0.85311965
171* SOX2_19829295_ChIP-Seq_ESCs_Human0.85311965
172TOP2B_26459242_ChIP-Seq_MCF-7_Human0.84912078
173GATA2_19941826_ChIP-Seq_K562_Human0.84731313
174EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.82154835
175RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.82114835
176SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.82072923
177TP53_22573176_ChIP-Seq_HFKS_Human0.81954940
178SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.79979958
179PCGF2_27294783_Chip-Seq_ESCs_Mouse0.79520310
180HTT_18923047_ChIP-ChIP_STHdh_Human0.79422945
181SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.79399925
182GATA2_21666600_ChIP-Seq_HMVEC_Human0.79209871

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006054_spinal_hemorrhage7.14407044
2MP0008438_abnormal_cutaneous_collagen6.62930502
3MP0001986_abnormal_taste_sensitivity6.07439542
4MP0002735_abnormal_chemical_nociception5.80992425
5MP0001968_abnormal_touch/_nociception5.46147871
6MP0005503_abnormal_tendon_morphology5.34560145
7MP0002736_abnormal_nociception_after4.67533230
8MP0004272_abnormal_basement_membrane4.49564971
9MP0010368_abnormal_lymphatic_system4.24408048
10MP0003279_aneurysm3.81424772
11MP0005275_abnormal_skin_tensile3.65852596
12MP0001835_abnormal_antigen_presentation3.28014448
13MP0006276_abnormal_autonomic_nervous3.05218870
14MP0005671_abnormal_response_to2.99416653
15MP0006082_CNS_inflammation2.87059012
16MP0002733_abnormal_thermal_nociception2.79093834
17MP0005623_abnormal_meninges_morphology2.66999425
18MP0001879_abnormal_lymphatic_vessel2.62458961
19MP0002148_abnormal_hypersensitivity_rea2.56928413
20MP0003195_calcinosis2.50482677
21MP0009384_cardiac_valve_regurgitation2.49643268
22MP0001542_abnormal_bone_strength2.48486302
23MP0009785_altered_susceptibility_to2.46163390
24MP0001970_abnormal_pain_threshold2.45183572
25MP0001958_emphysema2.44841037
26MP0004147_increased_porphyrin_level2.44556360
27MP0000767_abnormal_smooth_muscle2.31290420
28MP0004270_analgesia2.26671688
29MP0005257_abnormal_intraocular_pressure2.26509053
30MP0002734_abnormal_mechanical_nocicepti2.24441486
31MP0004858_abnormal_nervous_system2.21661933
32* MP0005464_abnormal_platelet_physiology2.21099027
33MP0003705_abnormal_hypodermis_morpholog2.20445709
34MP0009780_abnormal_chondrocyte_physiolo2.12992168
35MP0005000_abnormal_immune_tolerance2.09744042
36MP0003950_abnormal_plasma_membrane2.08450660
37MP0003436_decreased_susceptibility_to2.05182700
38MP0003941_abnormal_skin_development2.04127611
39MP0002419_abnormal_innate_immunity1.93327709
40MP0005025_abnormal_response_to1.92898549
41MP0002896_abnormal_bone_mineralization1.89379752
42MP0001800_abnormal_humoral_immune1.88176753
43MP0005508_abnormal_skeleton_morphology1.87357101
44MP0003566_abnormal_cell_adhesion1.81644842
45MP0002723_abnormal_immune_serum1.80155450
46MP0002452_abnormal_antigen_presenting1.76441813
47MP0001819_abnormal_immune_cell1.75156196
48MP0009250_abnormal_appendicular_skeleto1.72238339
49MP0002420_abnormal_adaptive_immunity1.70898591
50MP0003724_increased_susceptibility_to1.67290429
51MP0004510_myositis1.61809678
52MP0009053_abnormal_anal_canal1.58848428
53MP0001790_abnormal_immune_system1.58329124
54MP0005387_immune_system_phenotype1.58329124
55MP0009333_abnormal_splenocyte_physiolog1.58079614
56MP0001915_intracranial_hemorrhage1.53590272
57MP0002398_abnormal_bone_marrow1.50095823
58MP0003091_abnormal_cell_migration1.48279037
59MP0002295_abnormal_pulmonary_circulatio1.43546976
60MP0003656_abnormal_erythrocyte_physiolo1.43495298
61MP0002006_tumorigenesis1.43299253
62MP0003763_abnormal_thymus_physiology1.41786479
63MP0000685_abnormal_immune_system1.41141858
64MP0002168_other_aberrant_phenotype1.40795899
65MP0005390_skeleton_phenotype1.40449705
66MP0002751_abnormal_autonomic_nervous1.40178347
67MP0002396_abnormal_hematopoietic_system1.38422448
68MP0002998_abnormal_bone_remodeling1.32834342
69MP0005595_abnormal_vascular_smooth1.30843132
70MP0002405_respiratory_system_inflammati1.29370231
71MP0002108_abnormal_muscle_morphology1.28732385
72MP0000013_abnormal_adipose_tissue1.28413550
73MP0000716_abnormal_immune_system1.28364658
74MP0002067_abnormal_sensory_capabilities1.27628944
75MP0001853_heart_inflammation1.25529573
76MP0004084_abnormal_cardiac_muscle1.25254802
77MP0000343_altered_response_to1.24255721
78MP0009764_decreased_sensitivity_to1.23795390
79MP0005171_absent_coat_pigmentation1.20915764
80MP0002933_joint_inflammation1.20054839
81MP0002115_abnormal_skeleton_extremities1.17089278
82MP0000372_irregular_coat_pigmentation1.14841549
83MP0000163_abnormal_cartilage_morphology1.13913472
84MP0002429_abnormal_blood_cell1.12517849
85MP0001845_abnormal_inflammatory_respons1.11900819
86MP0001188_hyperpigmentation1.10848761
87MP0005075_abnormal_melanosome_morpholog1.10715713
88MP0000569_abnormal_digit_pigmentation1.10384698
89MP0002060_abnormal_skin_morphology1.09500321
90MP0005023_abnormal_wound_healing1.09116012
91MP0001614_abnormal_blood_vessel1.08962250
92MP0002254_reproductive_system_inflammat1.08409906
93MP0002128_abnormal_blood_circulation1.07855579
94MP0005197_abnormal_uvea_morphology1.07508308
95MP0000689_abnormal_spleen_morphology1.07351879
96MP0010386_abnormal_urinary_bladder1.07345850
97MP0003183_abnormal_peptide_metabolism1.07158636
98MP0000465_gastrointestinal_hemorrhage1.05209911
99MP0002166_altered_tumor_susceptibility1.04250042
100MP0002722_abnormal_immune_system1.03830873
101MP0002932_abnormal_joint_morphology1.03729547
102MP0002109_abnormal_limb_morphology1.02823205
103MP0002272_abnormal_nervous_system1.02686998
104MP0002925_abnormal_cardiovascular_devel1.02074083
105MP0000015_abnormal_ear_pigmentation1.01355530
106MP0005174_abnormal_tail_pigmentation1.01213975
107MP0003045_fibrosis0.98391670
108MP0008260_abnormal_autophagy0.96416482
109MP0005310_abnormal_salivary_gland0.95472792
110MP0000003_abnormal_adipose_tissue0.95322209
111MP0002113_abnormal_skeleton_development0.95282004
112MP0010155_abnormal_intestine_physiology0.94975968
113MP0009745_abnormal_behavioral_response0.93567904
114MP0000534_abnormal_ureter_morphology0.93315353
115MP0005164_abnormal_response_to0.93007082
116MP0005397_hematopoietic_system_phenotyp0.92416638
117MP0001545_abnormal_hematopoietic_system0.92416638
118MP0002876_abnormal_thyroid_physiology0.92084807
119MP0000858_altered_metastatic_potential0.91949591
120MP0005367_renal/urinary_system_phenotyp0.91489394
121MP0000516_abnormal_urinary_system0.91489394
122MP0000432_abnormal_head_morphology0.90058704
123MP0004808_abnormal_hematopoietic_stem0.88618278
124MP0003806_abnormal_nucleotide_metabolis0.88609708
125MP0009765_abnormal_xenobiotic_induced0.88179404
126MP0003935_abnormal_craniofacial_develop0.88097222
127MP0009697_abnormal_copulation0.86948888
128MP0001243_abnormal_dermal_layer0.86914383
129MP0003880_abnormal_central_pattern0.85780643
130MP0003942_abnormal_urinary_system0.85090130
131MP0003385_abnormal_body_wall0.83635517
132MP0002184_abnormal_innervation0.82953283
133MP0001299_abnormal_eye_distance/0.81506993
134MP0001984_abnormal_olfaction0.77875367
135MP0008469_abnormal_protein_level0.77686904
136MP0001440_abnormal_grooming_behavior0.77531144
137MP0000428_abnormal_craniofacial_morphol0.76886468
138MP0009278_abnormal_bone_marrow0.76572024
139MP0003303_peritoneal_inflammation0.76340862
140MP0008872_abnormal_physiological_respon0.75951694
141MP0001533_abnormal_skeleton_physiology0.75486232
142MP0003866_abnormal_defecation0.75329314
143MP0004883_abnormal_blood_vessel0.74191492
144MP0003448_altered_tumor_morphology0.73901553
145MP0005395_other_phenotype0.73658906
146MP0003795_abnormal_bone_structure0.73517407
147MP0004859_abnormal_synaptic_plasticity0.72839010
148MP0009046_muscle_twitch0.72448142
149MP0002127_abnormal_cardiovascular_syste0.72237820
150MP0003937_abnormal_limbs/digits/tail_de0.69525805
151MP0006138_congestive_heart_failure0.68759593
152MP0004947_skin_inflammation0.68719096
153MP0003828_pulmonary_edema0.68677152
154MP0000049_abnormal_middle_ear0.67826833
155MP0005083_abnormal_biliary_tract0.67289201
156MP0000751_myopathy0.67178190
157MP0008775_abnormal_heart_ventricle0.66735997
158MP0003755_abnormal_palate_morphology0.66582550
159MP0001905_abnormal_dopamine_level0.65942670
160MP0004036_abnormal_muscle_relaxation0.65317978
161MP0004811_abnormal_neuron_physiology0.65299745
162MP0001501_abnormal_sleep_pattern0.65118239
163MP0005165_increased_susceptibility_to0.64886382
164MP0002572_abnormal_emotion/affect_behav0.64454236
165MP0005166_decreased_susceptibility_to0.63961011
166MP0002282_abnormal_trachea_morphology0.63867621
167MP0000703_abnormal_thymus_morphology0.62774664
168MP0000230_abnormal_systemic_arterial0.61738596
169MP0008874_decreased_physiological_sensi0.61726251
170MP0005409_darkened_coat_color0.61719558
171MP0000427_abnormal_hair_cycle0.60441307
172MP0004142_abnormal_muscle_tone0.59210950
173MP0001784_abnormal_fluid_regulation0.58944830
174MP0003635_abnormal_synaptic_transmissio0.58891706
175MP0005187_abnormal_penis_morphology0.58694689
176MP0000249_abnormal_blood_vessel0.57959712
177MP0003172_abnormal_lysosome_physiology0.57430928
178MP0002095_abnormal_skin_pigmentation0.56599478
179MP0002116_abnormal_craniofacial_bone0.55858046
180MP0005084_abnormal_gallbladder_morpholo0.55344459
181MP0005193_abnormal_anterior_eye0.54468406
182MP0002009_preneoplasia0.54090512
183MP0004484_altered_response_of0.53343270
184MP0003283_abnormal_digestive_organ0.51976116
185MP0000266_abnormal_heart_morphology0.50764317
186MP0001175_abnormal_lung_morphology0.50329023
187MP0005388_respiratory_system_phenotype0.48949514
188MP0002133_abnormal_respiratory_system0.48949514
189MP0001664_abnormal_digestion0.48839844
190MP0004134_abnormal_chest_morphology0.48504565

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)6.38903029
2Protrusio acetabuli (HP:0003179)5.91100763
3Aortic dissection (HP:0002647)5.66319301
4Petechiae (HP:0000967)5.57268718
5Purpura (HP:0000979)5.45565507
6Vascular tortuosity (HP:0004948)5.38198251
7Hypophosphatemic rickets (HP:0004912)5.22389737
8Arterial tortuosity (HP:0005116)5.11703072
9Recurrent abscess formation (HP:0002722)5.01907591
10Abnormal platelet volume (HP:0011876)4.76776141
11Prolonged bleeding time (HP:0003010)4.74224333
12Increased mean platelet volume (HP:0011877)4.71864939
13Obstructive lung disease (HP:0006536)4.52150573
14Chronic obstructive pulmonary disease (HP:0006510)4.52150573
15Eczematoid dermatitis (HP:0000976)4.37679725
16Aortic aneurysm (HP:0004942)4.32994478
17Recurrent bacterial skin infections (HP:0005406)4.30302528
18Menorrhagia (HP:0000132)4.21753152
19Broad ribs (HP:0000885)4.18885081
20Soft skin (HP:0000977)4.17920554
21Follicular hyperkeratosis (HP:0007502)3.98715582
22Cardiovascular calcification (HP:0011915)3.95898249
23Spondylolisthesis (HP:0003302)3.91163590
24Abnormality of macrophages (HP:0004311)3.88330278
25Overgrowth (HP:0001548)3.83157746
26Optic neuritis (HP:0100653)3.75610864
27Retrobulbar optic neuritis (HP:0100654)3.75610864
28Peritonitis (HP:0002586)3.75318766
29Bladder diverticulum (HP:0000015)3.74496379
30Papilledema (HP:0001085)3.73147273
31Increased neuronal autofluorescent lipopigment (HP:0002074)3.68129733
32Hypothermia (HP:0002045)3.65262467
33Myocardial infarction (HP:0001658)3.63377940
34Facial diplegia (HP:0001349)3.48903982
35Gingival bleeding (HP:0000225)3.42423794
36Abnormality of dentin (HP:0010299)3.40916958
37Vascular calcification (HP:0004934)3.36374447
38Recurrent gram-negative bacterial infections (HP:0005420)3.33419926
39Dysautonomia (HP:0002459)3.31460930
40Myositis (HP:0100614)3.31136877
41Keratoconus (HP:0000563)3.29830250
42Increased corneal curvature (HP:0100692)3.29830250
43Cervical subluxation (HP:0003308)3.24772529
44Meningitis (HP:0001287)3.24657211
45Ankle contracture (HP:0006466)3.22979698
46Wormian bones (HP:0002645)3.17677395
47Chronic otitis media (HP:0000389)3.17653679
48Increased cerebral lipofuscin (HP:0011813)3.17412173
49Abnormality of the prostate (HP:0008775)3.15012580
50Cerebral aneurysm (HP:0004944)3.10525230
51Metaphyseal dysplasia (HP:0100255)3.07053039
52Broad metatarsal (HP:0001783)3.05261319
53Thyroid-stimulating hormone excess (HP:0002925)3.03343005
54Orchitis (HP:0100796)2.97594014
55Vasculitis (HP:0002633)2.96696649
56Stomatitis (HP:0010280)2.96348445
57Mediastinal lymphadenopathy (HP:0100721)2.93220109
58Increased density of long bones (HP:0006392)2.91674218
59Epistaxis (HP:0000421)2.91316220
60Recurrent fungal infections (HP:0002841)2.87140590
61Abnormal hair whorl (HP:0010721)2.86493756
62Aplastic anemia (HP:0001915)2.84969008
63Genu recurvatum (HP:0002816)2.82590797
64Cerebral palsy (HP:0100021)2.80208023
65Neonatal short-limb short stature (HP:0008921)2.76260908
66Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.75045253
67Mild short stature (HP:0003502)2.74733723
68Neuroendocrine neoplasm (HP:0100634)2.73942484
69Prostate neoplasm (HP:0100787)2.67293625
70Atrophic scars (HP:0001075)2.66022508
71Tetraparesis (HP:0002273)2.60126574
72Arthropathy (HP:0003040)2.59869143
73Aortic valve stenosis (HP:0001650)2.59140547
74Encephalitis (HP:0002383)2.58637576
75Recurrent skin infections (HP:0001581)2.57351968
76Dilatation of the ascending aorta (HP:0005111)2.57069801
77Vacuolated lymphocytes (HP:0001922)2.54649268
78Cellulitis (HP:0100658)2.51670514
79Blue sclerae (HP:0000592)2.51533753
80Abnormality of the vertebral endplates (HP:0005106)2.49844222
81Hemoptysis (HP:0002105)2.49275928
82Abnormality of pain sensation (HP:0010832)2.47517212
83Impaired pain sensation (HP:0007328)2.47517212
84Hypomagnesemia (HP:0002917)2.46659281
85Aortic regurgitation (HP:0001659)2.46502593
86Vertebral compression fractures (HP:0002953)2.44772561
87Recurrent viral infections (HP:0004429)2.44711746
88Hypoplasia of the iris (HP:0007676)2.44199345
89Flared iliac wings (HP:0002869)2.43360329
90Pheochromocytoma (HP:0002666)2.43239980
91Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.42435863
92Bowel diverticulosis (HP:0005222)2.41680907
93Mitral valve prolapse (HP:0001634)2.40943062
94Type 1 muscle fiber predominance (HP:0003803)2.40504040
95Ulnar claw (HP:0001178)2.40049329
96Keratoconjunctivitis sicca (HP:0001097)2.38373544
97Abnormality of the acetabulum (HP:0003170)2.37790005
98Abnormality of the pleura (HP:0002103)2.36634520
99Absent frontal sinuses (HP:0002688)2.36340881
100Craniofacial hyperostosis (HP:0004493)2.35700027
101Fragile skin (HP:0001030)2.35042916
102Autoamputation (HP:0001218)2.34896201
103Hyperextensible skin (HP:0000974)2.34232084
104Reduced antithrombin III activity (HP:0001976)2.32255871
105Type 2 muscle fiber atrophy (HP:0003554)2.29391735
106Shallow orbits (HP:0000586)2.29167080
107Wide anterior fontanel (HP:0000260)2.25473322
108Slender build (HP:0001533)2.25306983
109Hydroxyprolinuria (HP:0003080)2.25102296
110Abnormality of proline metabolism (HP:0010907)2.25102296
111Osteomyelitis (HP:0002754)2.25052282
112Increased serum ferritin (HP:0003281)2.24350465
113Hypoplasia of the odontoid process (HP:0003311)2.22441995
114Femoral bowing (HP:0002980)2.21481762
115Intestinal atresia (HP:0011100)2.21171953
116Elevated erythrocyte sedimentation rate (HP:0003565)2.20674625
117Abnormality of magnesium homeostasis (HP:0004921)2.18494249
118Spinal rigidity (HP:0003306)2.17451721
119Joint laxity (HP:0001388)2.14976458
120Tibial bowing (HP:0002982)2.14516726
121Wrist flexion contracture (HP:0001239)2.13522517
122Aneurysm (HP:0002617)2.12141255
123Glomerulopathy (HP:0100820)2.11832456
124Agammaglobulinemia (HP:0004432)2.09774458
125Gingivitis (HP:0000230)2.09307208
126Keratoconjunctivitis (HP:0001096)2.08983733
127Myokymia (HP:0002411)2.08523192
128Testicular atrophy (HP:0000029)2.06448308
129Delayed closure of the anterior fontanelle (HP:0001476)2.05635570
130Muscle fiber atrophy (HP:0100295)2.05622365
131Xerostomia (HP:0000217)2.04859064
132Febrile seizures (HP:0002373)2.03744796
133Spinal cord lesions (HP:0100561)2.02582240
134Syringomyelia (HP:0003396)2.02582240
135Pulmonary infiltrates (HP:0002113)2.01805339
136T lymphocytopenia (HP:0005403)2.01673083
137Loss of speech (HP:0002371)2.01495694
138Ovoid vertebral bodies (HP:0003300)2.00480054
139Nonimmune hydrops fetalis (HP:0001790)2.00018075
140Joint stiffness (HP:0001387)1.99966403
141Segmental peripheral demyelination/remyelination (HP:0003481)1.99446426
142Type I transferrin isoform profile (HP:0003642)1.98978001
143Abnormality of T cell number (HP:0011839)1.98314964
144Panhypogammaglobulinemia (HP:0003139)1.97792022
145Lymphoma (HP:0002665)1.97253671
146Skin rash (HP:0000988)1.95228655
147IgM deficiency (HP:0002850)1.95203701
148Mitral stenosis (HP:0001718)1.94704706
149Rickets (HP:0002748)1.94658425
150Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.94174111
151Paresthesia (HP:0003401)1.91987186
152Abnormality of the odontoid process (HP:0003310)1.91895958
153Keratitis (HP:0000491)1.91095025
154Cranial hyperostosis (HP:0004437)1.90796429
155Pulmonary artery stenosis (HP:0004415)1.90556119
156Coxa vara (HP:0002812)1.90341865
157Irregular vertebral endplates (HP:0003301)1.90203010
158Abnormal autonomic nervous system physiology (HP:0012332)1.89390799
159Striae distensae (HP:0001065)1.89086968
160Leukocytosis (HP:0001974)1.89063613
161Broad long bones (HP:0005622)1.88024003
162Chronic mucocutaneous candidiasis (HP:0002728)1.87582829
163Recurrent cutaneous fungal infections (HP:0011370)1.87582829
164Acute myeloid leukemia (HP:0004808)1.87436064
165Abnormal platelet function (HP:0011869)1.84979763
166Impaired platelet aggregation (HP:0003540)1.84979763
167Joint swelling (HP:0001386)1.83984619
168Acrocyanosis (HP:0001063)1.82892749
169Osteoarthritis (HP:0002758)1.82804160
170Abnormality of iron homeostasis (HP:0011031)1.82755208
171Arterial thrombosis (HP:0004420)1.81454180
172Autoimmune thrombocytopenia (HP:0001973)1.81177896
173Failure to thrive in infancy (HP:0001531)1.80251824
174Mesomelia (HP:0003027)1.80145162
175Inguinal hernia (HP:0000023)1.79311821
176Protruding ear (HP:0000411)1.78204242
177Sepsis (HP:0100806)1.77515800
178Adactyly (HP:0009776)1.76898474
179Neoplasm of the peripheral nervous system (HP:0100007)1.76536728
180Poor head control (HP:0002421)1.75734086
181Hypoventilation (HP:0002791)1.74903783
182Abnormality of calcium-phosphate metabolism (HP:0100530)1.73702160
183Abnormality of the aortic arch (HP:0012303)1.72610293
184Abnormality of Sharpey fibers (HP:0100685)1.72078943
185Spinal cord compression (HP:0002176)1.71832488
186Submucous cleft hard palate (HP:0000176)1.71691708
187Abnormality of liposaccharide metabolism (HP:0010968)1.71084866
188Abnormality of glycosphingolipid metabolism (HP:0004343)1.71084866
189Abnormality of glycolipid metabolism (HP:0010969)1.71084866
190Porencephaly (HP:0002132)1.70219074
191Urticaria (HP:0001025)1.69760358
192Camptodactyly of toe (HP:0001836)1.69267495
193Elbow flexion contracture (HP:0002987)1.68188251
194Areflexia of lower limbs (HP:0002522)1.65616912
195Scotoma (HP:0000575)1.64071893
196Hydroureter (HP:0000072)1.63939888
197Persistence of primary teeth (HP:0006335)1.62644993
198Increased variability in muscle fiber diameter (HP:0003557)1.61224475
199Termporal pattern (HP:0011008)1.61109264
200Tarsal synostosis (HP:0008368)1.60023773

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK4.09614337
2SIK34.03538994
3MAP3K123.87645996
4RIPK43.66336487
5MAP4K13.61223174
6ADRBK22.84243508
7PDGFRA2.77467027
8CASK2.59006654
9FRK2.47906656
10MAP3K142.45302921
11IRAK42.39019415
12DDR22.36079549
13EPHB22.33783415
14TGFBR22.24785602
15MATK2.20260189
16JAK32.14786294
17AKT32.04800778
18TEC2.04048120
19BLK1.98279324
20PTK2B1.91932557
21PIM21.89906175
22GRK11.86286702
23KIT1.85239098
24SYK1.84606297
25PAK21.83471475
26FER1.74647086
27MINK11.72790095
28GRK51.70605108
29ERN11.70095359
30FLT31.70034839
31NTRK11.67628648
32MST41.66959579
33PIK3CG1.59217704
34PTK21.58469528
35ITK1.55997852
36TGFBR11.54355194
37ERBB41.53695578
38TBK11.48809304
39FES1.48295376
40STK241.43161859
41PRPF4B1.42346623
42NEK91.41349862
43YES11.40171010
44MET1.36764586
45ZAP701.35236640
46ACVR1B1.31974227
47JAK11.31552521
48BTK1.28486932
49GRK71.27944111
50TRPM71.24096210
51PLK21.14851481
52STK381.14029589
53SGK21.12678054
54PAK41.11120880
55EPHA31.10071500
56PINK11.09609175
57MARK31.06415781
58PDGFRB1.06231441
59LCK1.05240289
60ROCK11.04583965
61LYN1.02575259
62CSF1R1.02247409
63PAK31.02075293
64TYK21.01835085
65TSSK60.99775385
66IRAK30.96847345
67LIMK10.93592586
68DAPK10.93342615
69WNK30.92759670
70MKNK20.91639769
71IKBKE0.90296241
72PNCK0.89440211
73MAP2K70.89438006
74NUAK10.89258093
75TAOK20.88365594
76IKBKB0.88156619
77ROCK20.84011793
78RPS6KA20.83583776
79PIM10.82700209
80MAPK70.79865669
81NTRK30.78637392
82PRKCD0.77806471
83FGFR30.76053076
84STK30.74949454
85CSK0.74688462
86LATS10.74571981
87STK100.74570516
88SGK4940.73531783
89SGK2230.73531783
90TNK20.73175004
91ARAF0.72023498
92TAOK30.71953040
93MAP2K60.70838052
94MAP3K20.70455810
95MOS0.69561763
96PRKG20.69051149
97STK160.67578602
98MELK0.67569213
99ADRBK10.66376266
100MYLK0.66263809
101PRKCE0.65734393
102IRAK10.64173219
103EIF2AK30.64084148
104BCR0.63780307
105TTN0.62715781
106STK390.62375140
107MAPK130.61104213
108RIPK10.60903924
109SGK30.60823621
110TRIM280.60583130
111HCK0.60466032
112KDR0.58985605
113ZAK0.56579095
114PDK10.56252228
115PLK30.55201532
116CLK10.53669438
117GSK3A0.52479456
118CDK80.52309626
119TAF10.51751134
120DAPK20.51298832
121NLK0.51266692
122MAP4K20.51244679
123ERBB30.51209148
124PRKD20.50949269
125BRSK20.50203259
126CDC42BPA0.49679716
127EIF2AK10.49490871
128PRKCQ0.48610626
129BMPR20.48009430
130PRKCH0.47626268
131FGFR40.47016451
132PRKCG0.45573572
133SCYL20.45052490
134ABL10.43106783
135LATS20.43062623
136BMPR1B0.42818988
137JAK20.42478795
138MKNK10.40753740
139VRK10.39635883
140TNIK0.39517280
141PRKD10.39443049
142MAP2K10.39318055
143PIK3CA0.38265348
144RPS6KA60.37251577
145RPS6KB10.37246349
146ABL20.36567840
147MAP3K30.34590240
148INSR0.34464323
149CAMK2A0.33073193
150MAP3K10.32990597
151NME20.32762593
152CHUK0.32440152
153RET0.32084352
154CSNK1A1L0.31990728
155SRC0.31374066
156FGR0.30343241
157TIE10.30203256
158DYRK20.30012092
159IGF1R0.29821543
160MAPKAPK20.29790106
161RPS6KL10.29329192
162RPS6KC10.29329192
163PRKCB0.28639388
164PRKG10.26113522
165ERBB20.25635284
166STK38L0.25578657
167MAPK10.25553606
168PLK40.21377114
169ILK0.19868695
170DMPK0.19210773
171EGFR0.18881406
172DYRK30.17869142

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045124.95987869
2Graft-versus-host disease_Homo sapiens_hsa053323.95570682
3Focal adhesion_Homo sapiens_hsa045103.38818559
4Glycosaminoglycan degradation_Homo sapiens_hsa005312.95186992
5Hematopoietic cell lineage_Homo sapiens_hsa046402.74728591
6Leishmaniasis_Homo sapiens_hsa051402.65182822
7Protein digestion and absorption_Homo sapiens_hsa049742.54466940
8Allograft rejection_Homo sapiens_hsa053302.54332981
9Dorso-ventral axis formation_Homo sapiens_hsa043202.42290292
10Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.40815496
11Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005342.38776482
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.30166665
13Type I diabetes mellitus_Homo sapiens_hsa049402.13199108
14Rheumatoid arthritis_Homo sapiens_hsa053232.04501199
15Salmonella infection_Homo sapiens_hsa051322.02614989
16Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.98298273
17TGF-beta signaling pathway_Homo sapiens_hsa043501.90774915
18PI3K-Akt signaling pathway_Homo sapiens_hsa041511.87727643
19Proteoglycans in cancer_Homo sapiens_hsa052051.84291058
20Adherens junction_Homo sapiens_hsa045201.79348891
21Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.77443089
22Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.72860069
23Measles_Homo sapiens_hsa051621.71611424
24Legionellosis_Homo sapiens_hsa051341.69684423
25Hippo signaling pathway_Homo sapiens_hsa043901.68825243
26Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.66328666
27Pertussis_Homo sapiens_hsa051331.65294047
28Toll-like receptor signaling pathway_Homo sapiens_hsa046201.63120990
29Tuberculosis_Homo sapiens_hsa051521.59816600
30Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.59320737
31MicroRNAs in cancer_Homo sapiens_hsa052061.55690018
32Autoimmune thyroid disease_Homo sapiens_hsa053201.55245379
33Synaptic vesicle cycle_Homo sapiens_hsa047211.54072881
34Basal cell carcinoma_Homo sapiens_hsa052171.49938671
35Osteoclast differentiation_Homo sapiens_hsa043801.48848730
36Phagosome_Homo sapiens_hsa041451.48449686
37Primary immunodeficiency_Homo sapiens_hsa053401.46925008
38Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.46253634
39Hedgehog signaling pathway_Homo sapiens_hsa043401.44607583
40Dilated cardiomyopathy_Homo sapiens_hsa054141.42576513
41Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.40907171
42NOD-like receptor signaling pathway_Homo sapiens_hsa046211.37256483
43Platelet activation_Homo sapiens_hsa046111.36061180
44Shigellosis_Homo sapiens_hsa051311.35389171
45Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.35174631
46Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.35079656
47Intestinal immune network for IgA production_Homo sapiens_hsa046721.34284443
48SNARE interactions in vesicular transport_Homo sapiens_hsa041301.33209663
49Chemokine signaling pathway_Homo sapiens_hsa040621.33089412
50Small cell lung cancer_Homo sapiens_hsa052221.31756898
51Olfactory transduction_Homo sapiens_hsa047401.30029539
52B cell receptor signaling pathway_Homo sapiens_hsa046621.27377834
53Taste transduction_Homo sapiens_hsa047421.27349687
54NF-kappa B signaling pathway_Homo sapiens_hsa040641.27064359
55Jak-STAT signaling pathway_Homo sapiens_hsa046301.27039511
56Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.26047783
57RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.25959211
58Leukocyte transendothelial migration_Homo sapiens_hsa046701.25687344
59* Complement and coagulation cascades_Homo sapiens_hsa046101.25638345
60Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.25519310
61Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.24181843
62Wnt signaling pathway_Homo sapiens_hsa043101.20684184
63Pathways in cancer_Homo sapiens_hsa052001.18510492
64Collecting duct acid secretion_Homo sapiens_hsa049661.18427565
65Asthma_Homo sapiens_hsa053101.18132000
66Ras signaling pathway_Homo sapiens_hsa040141.17614636
67Selenocompound metabolism_Homo sapiens_hsa004501.16971204
68T cell receptor signaling pathway_Homo sapiens_hsa046601.16906946
69Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.14194773
70Influenza A_Homo sapiens_hsa051641.12531466
71Vascular smooth muscle contraction_Homo sapiens_hsa042701.10906758
72Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.09644815
73Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.08263742
74Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.06917463
75Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.04400820
76Sulfur metabolism_Homo sapiens_hsa009201.03693296
77Axon guidance_Homo sapiens_hsa043601.03285090
78Antigen processing and presentation_Homo sapiens_hsa046121.02803924
79Serotonergic synapse_Homo sapiens_hsa047261.00521243
80Neurotrophin signaling pathway_Homo sapiens_hsa047220.99795833
81* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.99745755
82Toxoplasmosis_Homo sapiens_hsa051450.99537328
83Apoptosis_Homo sapiens_hsa042100.99417828
84Viral myocarditis_Homo sapiens_hsa054160.99412022
85Malaria_Homo sapiens_hsa051440.94960787
86Hepatitis B_Homo sapiens_hsa051610.92645921
87Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.91788956
88Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.91241676
89Thyroid cancer_Homo sapiens_hsa052160.90264547
90Renin-angiotensin system_Homo sapiens_hsa046140.88055923
91Tight junction_Homo sapiens_hsa045300.85535888
92ABC transporters_Homo sapiens_hsa020100.85512592
93African trypanosomiasis_Homo sapiens_hsa051430.85265556
94Prolactin signaling pathway_Homo sapiens_hsa049170.84676078
95Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.84139755
96Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.80885465
97Protein export_Homo sapiens_hsa030600.80833208
98Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.80752417
99p53 signaling pathway_Homo sapiens_hsa041150.79931694
100Lysosome_Homo sapiens_hsa041420.79585183
101Melanogenesis_Homo sapiens_hsa049160.79329335
102Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.78094342
103Phosphatidylinositol signaling system_Homo sapiens_hsa040700.78081431
104cGMP-PKG signaling pathway_Homo sapiens_hsa040220.77935471
105Phospholipase D signaling pathway_Homo sapiens_hsa040720.77404006
106Morphine addiction_Homo sapiens_hsa050320.75579347
107Proteasome_Homo sapiens_hsa030500.72272075
108Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.72129520
109Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.71941064
110Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.70145687
111Phototransduction_Homo sapiens_hsa047440.70126164
112TNF signaling pathway_Homo sapiens_hsa046680.68457040
113Sphingolipid signaling pathway_Homo sapiens_hsa040710.68203087
114N-Glycan biosynthesis_Homo sapiens_hsa005100.68159635
115Fatty acid elongation_Homo sapiens_hsa000620.66737138
116Bladder cancer_Homo sapiens_hsa052190.66475361
117Regulation of autophagy_Homo sapiens_hsa041400.65020451
118Hepatitis C_Homo sapiens_hsa051600.64285847
119Epstein-Barr virus infection_Homo sapiens_hsa051690.63390869
120Acute myeloid leukemia_Homo sapiens_hsa052210.62552113
121Insulin secretion_Homo sapiens_hsa049110.59408085
122Herpes simplex infection_Homo sapiens_hsa051680.58257457
123Calcium signaling pathway_Homo sapiens_hsa040200.58105875
124Prostate cancer_Homo sapiens_hsa052150.55414483
125Vibrio cholerae infection_Homo sapiens_hsa051100.54731242
126Steroid hormone biosynthesis_Homo sapiens_hsa001400.53531022
127Sphingolipid metabolism_Homo sapiens_hsa006000.52655445
128Cholinergic synapse_Homo sapiens_hsa047250.51150087
129Circadian entrainment_Homo sapiens_hsa047130.49743774
130Carbohydrate digestion and absorption_Homo sapiens_hsa049730.49453249
131cAMP signaling pathway_Homo sapiens_hsa040240.49084398
132Dopaminergic synapse_Homo sapiens_hsa047280.49001344
133Gap junction_Homo sapiens_hsa045400.47766211
134Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.47154422
135Melanoma_Homo sapiens_hsa052180.47125622
136Rap1 signaling pathway_Homo sapiens_hsa040150.46766768
137Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.46678161
138Staphylococcus aureus infection_Homo sapiens_hsa051500.46624201
139Thyroid hormone synthesis_Homo sapiens_hsa049180.46183448
140AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.45698417
141Endocytosis_Homo sapiens_hsa041440.45364074
142Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.44049881
143Non-small cell lung cancer_Homo sapiens_hsa052230.44007209
144Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.43694722
145Estrogen signaling pathway_Homo sapiens_hsa049150.43520810
146Regulation of actin cytoskeleton_Homo sapiens_hsa048100.42578896
147Pancreatic cancer_Homo sapiens_hsa052120.39659173
148Amoebiasis_Homo sapiens_hsa051460.39658210
149MAPK signaling pathway_Homo sapiens_hsa040100.39560764
150Salivary secretion_Homo sapiens_hsa049700.39323130
151Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.39189981
152Steroid biosynthesis_Homo sapiens_hsa001000.38000209
153Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.37345513
154Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.36631072
155Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.31493967
156Starch and sucrose metabolism_Homo sapiens_hsa005000.29538100
157Basal transcription factors_Homo sapiens_hsa030220.29371170
158Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.29263875
159Notch signaling pathway_Homo sapiens_hsa043300.28786927
160Glioma_Homo sapiens_hsa052140.27381514
161Thyroid hormone signaling pathway_Homo sapiens_hsa049190.26088369
162Renin secretion_Homo sapiens_hsa049240.25888852
163Glycerolipid metabolism_Homo sapiens_hsa005610.25883152
164Transcriptional misregulation in cancer_Homo sapiens_hsa052020.25284019
165Glutathione metabolism_Homo sapiens_hsa004800.25181311
166Arachidonic acid metabolism_Homo sapiens_hsa005900.24282797
167Chronic myeloid leukemia_Homo sapiens_hsa052200.22092796

Most similar genes based on co-expression Upload to Enrichr

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