F7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes coagulation factor VII which is a vitamin K-dependent factor essential for hemostasis. This factor circulates in the blood in a zymogen form, and is converted to an active form by either factor IXa, factor Xa, factor XIIa, or thrombin by minor proteolysis. Upon activation of the factor VII, a heavy chain containing a catalytic domain and a light chain containing 2 EGF-like domains are generated, and two chains are held together by a disulfide bond. In the presence of factor III and calcium ions, the activated factor then further activates the coagulation cascade by converting factor IX to factor IXa and/or factor X to factor Xa. Defects in this gene can cause coagulopathy. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing to generate mature polypeptides. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1exogenous drug catabolic process (GO:0042738)6.87061076
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.85527456
3L-phenylalanine catabolic process (GO:0006559)6.85527456
4epoxygenase P450 pathway (GO:0019373)6.81846484
5omega-hydroxylase P450 pathway (GO:0097267)6.59972520
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.51508404
7L-phenylalanine metabolic process (GO:0006558)6.51508404
8regulation of plasminogen activation (GO:0010755)6.30354124
9aromatic amino acid family catabolic process (GO:0009074)6.26598869
10triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.20604467
11indole-containing compound catabolic process (GO:0042436)5.74894853
12indolalkylamine catabolic process (GO:0046218)5.74894853
13tryptophan catabolic process (GO:0006569)5.74894853
14kynurenine metabolic process (GO:0070189)5.59343013
15urea cycle (GO:0000050)5.57836207
16urea metabolic process (GO:0019627)5.57836207
17high-density lipoprotein particle remodeling (GO:0034375)5.54288622
18bile acid biosynthetic process (GO:0006699)5.52867002
19complement activation, alternative pathway (GO:0006957)5.45168328
20* protein carboxylation (GO:0018214)5.43582145
21* peptidyl-glutamic acid carboxylation (GO:0017187)5.43582145
22tryptophan metabolic process (GO:0006568)5.41162172
23negative regulation of fibrinolysis (GO:0051918)5.39118115
24glyoxylate metabolic process (GO:0046487)5.26677816
25regulation of protein activation cascade (GO:2000257)5.18734747
26alpha-linolenic acid metabolic process (GO:0036109)5.16246590
27regulation of fibrinolysis (GO:0051917)5.14406096
28nitrogen cycle metabolic process (GO:0071941)5.10930005
29negative regulation of blood coagulation (GO:0030195)4.96423970
30negative regulation of hemostasis (GO:1900047)4.96423970
31reverse cholesterol transport (GO:0043691)4.90768337
32regulation of cholesterol esterification (GO:0010872)4.89408799
33sulfur amino acid catabolic process (GO:0000098)4.89406492
34regulation of complement activation (GO:0030449)4.87049837
35drug metabolic process (GO:0017144)4.86605742
36protein-lipid complex remodeling (GO:0034368)4.82161245
37macromolecular complex remodeling (GO:0034367)4.82161245
38plasma lipoprotein particle remodeling (GO:0034369)4.82161245
39cysteine metabolic process (GO:0006534)4.78447011
40phospholipid efflux (GO:0033700)4.72178860
41bile acid metabolic process (GO:0008206)4.72051242
42fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.70224455
43ethanol metabolic process (GO:0006067)4.64885052
44regulation of humoral immune response (GO:0002920)4.64110812
45regulation of apoptotic cell clearance (GO:2000425)4.63310983
46oxidative demethylation (GO:0070989)4.59949549
47regulation of triglyceride catabolic process (GO:0010896)4.58193378
48plasma lipoprotein particle clearance (GO:0034381)4.55574201
49serine family amino acid catabolic process (GO:0009071)4.53773095
50intestinal cholesterol absorption (GO:0030299)4.52072755
51negative regulation of coagulation (GO:0050819)4.51228562
52aromatic amino acid family metabolic process (GO:0009072)4.49722315
53negative regulation of wound healing (GO:0061045)4.42107575
54homocysteine metabolic process (GO:0050667)4.40005649
55tyrosine metabolic process (GO:0006570)4.38131301
56phenylpropanoid metabolic process (GO:0009698)4.32684108
57positive regulation of fatty acid biosynthetic process (GO:0045723)4.31555789
58cholesterol efflux (GO:0033344)4.31106870
59negative regulation of cholesterol transport (GO:0032375)4.30474940
60negative regulation of sterol transport (GO:0032372)4.30474940
61acylglycerol homeostasis (GO:0055090)4.30261192
62triglyceride homeostasis (GO:0070328)4.30261192
63aldehyde catabolic process (GO:0046185)4.28422297
64negative regulation of protein activation cascade (GO:2000258)4.26015598
65low-density lipoprotein particle remodeling (GO:0034374)4.24205270
66amino-acid betaine metabolic process (GO:0006577)4.19715370
67alpha-amino acid catabolic process (GO:1901606)4.15519110
68lysine catabolic process (GO:0006554)4.06005667
69lysine metabolic process (GO:0006553)4.06005667
70cellular glucuronidation (GO:0052695)4.03210766
71indolalkylamine metabolic process (GO:0006586)4.03024790
72fibrinolysis (GO:0042730)4.02910024
73* positive regulation of blood coagulation (GO:0030194)4.02025985
74* positive regulation of hemostasis (GO:1900048)4.02025985
75bile acid and bile salt transport (GO:0015721)4.00754642
76imidazole-containing compound metabolic process (GO:0052803)4.00209147
77amine catabolic process (GO:0009310)3.99910746
78cellular biogenic amine catabolic process (GO:0042402)3.99910746
79cellular ketone body metabolic process (GO:0046950)3.99909130
80phospholipid homeostasis (GO:0055091)3.94359175
81plasma lipoprotein particle assembly (GO:0034377)3.93775818
82coenzyme catabolic process (GO:0009109)3.89728647
83cytolysis (GO:0019835)3.88004914
84regulation of lipoprotein particle clearance (GO:0010984)3.85301868
85glycine metabolic process (GO:0006544)3.83975686
86benzene-containing compound metabolic process (GO:0042537)3.83081327
87S-adenosylmethionine metabolic process (GO:0046500)3.81196103
88cellular amino acid catabolic process (GO:0009063)3.79730633
89plasma lipoprotein particle organization (GO:0071827)3.78182210
90proline metabolic process (GO:0006560)3.78166603
91arginine metabolic process (GO:0006525)3.77760695
92cofactor catabolic process (GO:0051187)3.76859616
93acute-phase response (GO:0006953)3.76036401
94glutamate metabolic process (GO:0006536)3.75880654
95positive regulation of lipid catabolic process (GO:0050996)3.74183510
96blood coagulation, intrinsic pathway (GO:0007597)3.74086370
97uronic acid metabolic process (GO:0006063)3.71647205
98glucuronate metabolic process (GO:0019585)3.71647205
99cellular modified amino acid catabolic process (GO:0042219)3.70711893
100dicarboxylic acid biosynthetic process (GO:0043650)3.69933213
101complement activation (GO:0006956)3.69061763
102ethanol oxidation (GO:0006069)3.68984815
103* positive regulation of coagulation (GO:0050820)3.66969246
104positive regulation of lipoprotein lipase activity (GO:0051006)3.66498031
105positive regulation of triglyceride lipase activity (GO:0061365)3.66498031
106opsonization (GO:0008228)3.64573761
107* protein activation cascade (GO:0072376)3.64415103
108cholesterol homeostasis (GO:0042632)3.63998179
109acute inflammatory response (GO:0002526)3.62541497
110serine family amino acid metabolic process (GO:0009069)3.61484740
111very-low-density lipoprotein particle assembly (GO:0034379)3.60565647
112negative regulation of lipid transport (GO:0032369)3.59350794
113complement activation, classical pathway (GO:0006958)3.59333866
114alkaloid metabolic process (GO:0009820)3.59204976
115sterol homeostasis (GO:0055092)3.58636606
116protein-lipid complex subunit organization (GO:0071825)3.56851932
117drug catabolic process (GO:0042737)3.56116426
118protein-lipid complex assembly (GO:0065005)3.55307716
119negative regulation of complement activation (GO:0045916)3.53058611
120NAD biosynthetic process (GO:0009435)3.49631375
121lipoprotein metabolic process (GO:0042157)3.47809563
122regulation of cholesterol homeostasis (GO:2000188)3.47766686
123negative regulation of lipase activity (GO:0060192)3.47096787
124positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.45928161
125ketone body metabolic process (GO:1902224)3.43984028
126serine family amino acid biosynthetic process (GO:0009070)3.42048048
127cholesterol transport (GO:0030301)3.40640388
128sterol transport (GO:0015918)3.40640388
129nicotinamide nucleotide biosynthetic process (GO:0019359)3.39956465
130pyridine nucleotide biosynthetic process (GO:0019363)3.39956465

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse7.67020629
2PPARA_22158963_ChIP-Seq_LIVER_Mouse6.61319695
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.40058752
4LXR_22158963_ChIP-Seq_LIVER_Mouse5.98582541
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.92837806
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.70518177
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.50750488
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.66896218
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.61099553
10IRF8_22096565_ChIP-ChIP_GC-B_Human2.70836923
11BP1_19119308_ChIP-ChIP_Hs578T_Human2.35642137
12ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.9037312
13IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.99409429
14IRF8_21731497_ChIP-ChIP_J774_Mouse1.98126378
15Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.91853102
16TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.89276950
17THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.83993165
18TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.75822558
19HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.70945716
20STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.64573435
21STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.59593394
22IRF8_27001747_Chip-Seq_BMDM_Mouse1.54132250
23* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.49272223
24GATA1_22025678_ChIP-Seq_K562_Human1.47902462
25NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.47404605
26CLOCK_20551151_ChIP-Seq_293T_Human1.45234799
27* FOXA2_19822575_ChIP-Seq_HepG2_Human1.41552757
28* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.39354559
29RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.35941473
30ESR1_20079471_ChIP-ChIP_T-47D_Human1.34843827
31HTT_18923047_ChIP-ChIP_STHdh_Human1.25186812
32E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.23444984
33* HNF4A_19822575_ChIP-Seq_HepG2_Human1.22131436
34TRIM28_21343339_ChIP-Seq_HEK293_Human1.16474524
35RXRA_24833708_ChIP-Seq_LIVER_Mouse1.11630266
36RARG_19884340_ChIP-ChIP_MEFs_Mouse1.08534988
37MYB_21317192_ChIP-Seq_ERMYB_Mouse1.05658155
38BRD4_27068464_Chip-Seq_AML-cells_Mouse1.01713336
39CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.01445135
40ERG_21242973_ChIP-ChIP_JURKAT_Human0.99969985
41SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.98981643
42SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.98201853
43TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.95707731
44ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.95029910
45IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.94477969
46CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.94349340
47PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.89772660
48CTCF_27219007_Chip-Seq_Bcells_Human0.88539022
49SOX2_27498859_Chip-Seq_STOMACH_Mouse0.88404018
50NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.87850141
51SMC4_20622854_ChIP-Seq_HELA_Human0.87399199
52BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.85669253
53* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.84249008
54GATA4_25053715_ChIP-Seq_YYC3_Human0.79710992
55* GATA6_25053715_ChIP-Seq_YYC3_Human0.79160814
56LXR_22292898_ChIP-Seq_THP-1_Human0.78932560
57RAC3_21632823_ChIP-Seq_H3396_Human0.78864450
58* DNAJC2_21179169_ChIP-ChIP_NT2_Human0.77592033
59PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.77394252
60E2F1_20622854_ChIP-Seq_HELA_Human0.76539422
61NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.76296749
62NRF2_20460467_ChIP-Seq_MEFs_Mouse0.76296749
63POU5F1_16518401_ChIP-PET_MESCs_Mouse0.75895683
64STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.74838423
65RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.73828114
66ELF1_20517297_ChIP-Seq_JURKAT_Human0.72759317
67ESR1_15608294_ChIP-ChIP_MCF-7_Human0.72154870
68KAP1_22055183_ChIP-Seq_ESCs_Mouse0.71905620
69FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.71086296
70P68_20966046_ChIP-Seq_HELA_Human0.70476773
71SALL4_18804426_ChIP-ChIP_XEN_Mouse0.70455748
72SOX2_21211035_ChIP-Seq_LN229_Human0.69990418
73EGR1_19032775_ChIP-ChIP_M12_Human0.69891793
74MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.69383608
75SRY_22984422_ChIP-ChIP_TESTIS_Rat0.68811182
76* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.68777582
77ESR2_21235772_ChIP-Seq_MCF-7_Human0.67921101
78SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.67169863
79CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.66622077
80GATA1_19941827_ChIP-Seq_MEL_Mouse0.66535621
81NFIB_24661679_ChIP-Seq_LUNG_Mouse0.65385467
82PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.65329887
83RARA_24833708_ChIP-Seq_LIVER_Mouse0.65015479
84SA1_27219007_Chip-Seq_Bcells_Human0.63539887
85* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.63006569
86TET1_21451524_ChIP-Seq_MESCs_Mouse0.62925127
87EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.62838724
88PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.62208484
89RACK7_27058665_Chip-Seq_MCF-7_Human0.61833886
90ZNF263_19887448_ChIP-Seq_K562_Human0.61157577
91SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.61006137
92JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.60990978
93GATA2_19941826_ChIP-Seq_K562_Human0.60797535
94GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.60263660
95GATA1_19941826_ChIP-Seq_K562_Human0.60110322
96BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.59675753
97SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.59380824
98AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.59228386
99VDR_24787735_ChIP-Seq_THP-1_Human0.57892686
100AUTS2_25519132_ChIP-Seq_293T-REX_Human0.57717860
101P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.57102304
102NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.57046841
103DROSHA_22980978_ChIP-Seq_HELA_Human0.56830111
104CTCF_20526341_ChIP-Seq_ESCs_Human0.56571482
105EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.56117029
106ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.56059677
107* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.55612833
108TCF4_18268006_ChIP-ChIP_LS174T_Human0.55450937
109TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.55417355
110RAD21_21589869_ChIP-Seq_MESCs_Mouse0.55252267
111* NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.55113264
112CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.54949010
113TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.54331440
114CEBPB_22108803_ChIP-Seq_LS180_Human0.54110270
115MYC_27129775_Chip-Seq_CORNEA_Mouse0.53997712
116ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.53813423
117PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.53497921
118* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.52519773
119MYC_19829295_ChIP-Seq_ESCs_Human0.52396119
120PU_27001747_Chip-Seq_BMDM_Mouse0.52099657
121STAT3_1855785_ChIP-Seq_MESCs_Mouse0.51816293
122PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.51642142
123RARB_24833708_ChIP-Seq_LIVER_Mouse0.51639057
124PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.51508649
125PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.51284759
126* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.48763022
127SOX2_20726797_ChIP-Seq_SW620_Human0.48267543
128CDX2_20551321_ChIP-Seq_CACO-2_Human0.48222565
129NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.47953292
130SPI1_20517297_ChIP-Seq_HL60_Human0.47176314
131BCOR_27268052_Chip-Seq_Bcells_Human0.47044859
132FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.46702156
133FOXO3_23340844_ChIP-Seq_DLD1_Human0.46549205
134PPAR_26484153_Chip-Seq_NCI-H1993_Human0.46219837
135* CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.46181693
136ESR1_21235772_ChIP-Seq_MCF-7_Human0.46108160
137* MYC_19915707_ChIP-ChIP_AK7_Human0.45863587
138FOXA1_25552417_ChIP-Seq_VCAP_Human0.45521076
139* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.45339978
140E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.44667518
141MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.44378517
142TAF2_19829295_ChIP-Seq_ESCs_Human0.44060363
143AR_20517297_ChIP-Seq_VCAP_Human0.43796907

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.42180769
2MP0005360_urolithiasis6.85542322
3MP0005085_abnormal_gallbladder_physiolo5.65414192
4MP0005365_abnormal_bile_salt5.45748875
5MP0008875_abnormal_xenobiotic_pharmacok4.59813865
6MP0009840_abnormal_foam_cell3.88625276
7MP0003806_abnormal_nucleotide_metabolis3.70802399
8MP0010329_abnormal_lipoprotein_level3.45827628
9MP0003252_abnormal_bile_duct3.35840514
10MP0005083_abnormal_biliary_tract3.05061866
11MP0003191_abnormal_cellular_cholesterol3.00439126
12MP0003195_calcinosis2.65426431
13MP0005332_abnormal_amino_acid2.49410587
14MP0001666_abnormal_nutrient_absorption2.23422526
15MP0000609_abnormal_liver_physiology2.12438193
16MP0002118_abnormal_lipid_homeostasis2.02558672
17MP0004019_abnormal_vitamin_homeostasis1.96983612
18MP0002138_abnormal_hepatobiliary_system1.96846596
19MP0005319_abnormal_enzyme/_coenzyme1.83124988
20MP0005451_abnormal_body_composition1.69087496
21MP0000566_synostosis1.68818865
22MP0003436_decreased_susceptibility_to1.64285331
23MP0001764_abnormal_homeostasis1.54158421
24MP0005584_abnormal_enzyme/coenzyme_acti1.53701809
25MP0003868_abnormal_feces_composition1.49930028
26MP0003011_delayed_dark_adaptation1.46542957
27MP0009764_decreased_sensitivity_to1.46024452
28MP0000604_amyloidosis1.44186185
29MP0003186_abnormal_redox_activity1.38251510
30MP0003705_abnormal_hypodermis_morpholog1.35709687
31MP0003724_increased_susceptibility_to1.35339958
32MP0005058_abnormal_lysosome_morphology1.33899628
33MP0003656_abnormal_erythrocyte_physiolo1.30988685
34MP0009697_abnormal_copulation1.27718721
35* MP0008469_abnormal_protein_level1.27588425
36MP0002132_abnormal_respiratory_system1.21894752
37MP0009763_increased_sensitivity_to1.21156712
38MP0000598_abnormal_liver_morphology1.21107586
39MP0003122_maternal_imprinting1.20478211
40MP0006082_CNS_inflammation1.19039042
41MP0009643_abnormal_urine_homeostasis1.18546488
42MP0005464_abnormal_platelet_physiology1.15812826
43MP0001835_abnormal_antigen_presentation1.13380774
44MP0002419_abnormal_innate_immunity1.08828971
45MP0003690_abnormal_glial_cell1.07321822
46MP0001915_intracranial_hemorrhage1.05292937
47MP0002254_reproductive_system_inflammat1.02685680
48MP0003879_abnormal_hair_cell0.97130580
49MP0009785_altered_susceptibility_to0.97042565
50MP0005647_abnormal_sex_gland0.95707668
51MP0003075_altered_response_to0.95642560
52MP0005025_abnormal_response_to0.91986420
53MP0003303_peritoneal_inflammation0.91880370
54MP0009642_abnormal_blood_homeostasis0.91043510
55MP0004782_abnormal_surfactant_physiolog0.90898263
56MP0005670_abnormal_white_adipose0.87826601
57MP0002971_abnormal_brown_adipose0.85860685
58MP0005408_hypopigmentation0.84098520
59MP0002249_abnormal_larynx_morphology0.82866751
60MP0004130_abnormal_muscle_cell0.82607101
61MP0005636_abnormal_mineral_homeostasis0.81308053
62MP0002089_abnormal_postnatal_growth/wei0.81137103
63MP0001845_abnormal_inflammatory_respons0.78788769
64MP0005334_abnormal_fat_pad0.77672062
65MP0002282_abnormal_trachea_morphology0.77492929
66MP0005166_decreased_susceptibility_to0.76831336
67MP0005376_homeostasis/metabolism_phenot0.75324380
68MP0009765_abnormal_xenobiotic_induced0.73364217
69MP0005395_other_phenotype0.72990101
70MP0005535_abnormal_body_temperature0.70623457
71MP0001533_abnormal_skeleton_physiology0.70246166
72MP0003172_abnormal_lysosome_physiology0.69886972
73MP0001853_heart_inflammation0.69317005
74MP0002078_abnormal_glucose_homeostasis0.69236050
75MP0002168_other_aberrant_phenotype0.69153653
76MP0001790_abnormal_immune_system0.67706705
77MP0005387_immune_system_phenotype0.67706705
78MP0003329_amyloid_beta_deposits0.67137623
79MP0010368_abnormal_lymphatic_system0.66833069
80MP0004947_skin_inflammation0.65170036
81MP0002148_abnormal_hypersensitivity_rea0.64398046
82MP0005000_abnormal_immune_tolerance0.63022019
83MP0004510_myositis0.62289183
84MP0005448_abnormal_energy_balance0.61608466
85MP0006036_abnormal_mitochondrial_physio0.61025809
86MP0008873_increased_physiological_sensi0.58269243
87MP0002136_abnormal_kidney_physiology0.57497718
88MP0001756_abnormal_urination0.57111766
89MP0001800_abnormal_humoral_immune0.55669446
90MP0000685_abnormal_immune_system0.55655107
91MP0005084_abnormal_gallbladder_morpholo0.55084764
92MP0002876_abnormal_thyroid_physiology0.54403215
93MP0002723_abnormal_immune_serum0.53122462
94MP0000249_abnormal_blood_vessel0.53087019
95MP0002909_abnormal_adrenal_gland0.52096336
96MP0005220_abnormal_exocrine_pancreas0.51066354
97MP0001661_extended_life_span0.50721336
98MP0009115_abnormal_fat_cell0.50691873
99MP0008872_abnormal_physiological_respon0.50260902
100MP0009053_abnormal_anal_canal0.50090132
101MP0005164_abnormal_response_to0.49906683
102MP0005248_abnormal_Harderian_gland0.49773567
103MP0003638_abnormal_response/metabolism_0.49689790
104MP0002452_abnormal_antigen_presenting0.49563206
105MP0004883_abnormal_blood_vessel0.48710080
106MP0003300_gastrointestinal_ulcer0.48192091
107MP0001881_abnormal_mammary_gland0.46675655
108MP0000639_abnormal_adrenal_gland0.46206285
109MP0005187_abnormal_penis_morphology0.46183824
110MP0005266_abnormal_metabolism0.45532635
111MP0005409_darkened_coat_color0.44553756
112MP0000343_altered_response_to0.44380301
113MP0005023_abnormal_wound_healing0.44226536
114MP0002090_abnormal_vision0.43668209
115MP0008874_decreased_physiological_sensi0.43491203
116MP0009780_abnormal_chondrocyte_physiolo0.42780967
117MP0003878_abnormal_ear_physiology0.42504145
118MP0005377_hearing/vestibular/ear_phenot0.42504145
119MP0000003_abnormal_adipose_tissue0.41681399
120MP0004272_abnormal_basement_membrane0.40158746
121MP0004264_abnormal_extraembryonic_tissu0.39385879
122MP0003953_abnormal_hormone_level0.38594019
123MP0002970_abnormal_white_adipose0.36047302
124MP0005646_abnormal_pituitary_gland0.31906746
125MP0005167_abnormal_blood-brain_barrier0.30420086
126MP0005379_endocrine/exocrine_gland_phen0.30261254
127MP0000467_abnormal_esophagus_morphology0.29112579
128MP0003718_maternal_effect0.28666847
129MP0005375_adipose_tissue_phenotype0.27034001
130MP0009384_cardiac_valve_regurgitation0.26943620
131MP0003632_abnormal_nervous_system0.25953882
132MP0001944_abnormal_pancreas_morphology0.24362514

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.21453147
2Abnormality of aromatic amino acid family metabolism (HP:0004338)6.67792804
3Intrahepatic cholestasis (HP:0001406)6.52654684
4Prolonged partial thromboplastin time (HP:0003645)6.42535527
5Abnormality of monocarboxylic acid metabolism (HP:0010996)6.20289813
6Xanthomatosis (HP:0000991)6.00801463
7Hypobetalipoproteinemia (HP:0003563)5.62741114
8Hyperlipoproteinemia (HP:0010980)5.24971696
9Complement deficiency (HP:0004431)5.24169271
10* Joint hemorrhage (HP:0005261)4.94237992
11Abnormality of the common coagulation pathway (HP:0010990)4.54256894
12Recurrent gram-negative bacterial infections (HP:0005420)4.42786245
13Hypolipoproteinemia (HP:0010981)4.34225540
14Epidermoid cyst (HP:0200040)4.26343703
15Hyperammonemia (HP:0001987)4.12337691
16Abnormality of complement system (HP:0005339)4.10485622
17Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.06036679
18Hypoalphalipoproteinemia (HP:0003233)3.94428678
19Abnormality of sulfur amino acid metabolism (HP:0004339)3.85969445
20Abnormality of glutamine family amino acid metabolism (HP:0010902)3.85155246
21Fat malabsorption (HP:0002630)3.78844226
22Systemic lupus erythematosus (HP:0002725)3.78111561
23Abnormality of methionine metabolism (HP:0010901)3.75650899
24Abnormality of pyrimidine metabolism (HP:0004353)3.74155477
25Ketosis (HP:0001946)3.72848533
26Hyperglycinemia (HP:0002154)3.70037078
27Hypercholesterolemia (HP:0003124)3.68246187
28Abnormality of aspartate family amino acid metabolism (HP:0010899)3.57988999
29Abnormality of the intrinsic pathway (HP:0010989)3.47491161
30Myocardial infarction (HP:0001658)3.47105354
31Conjugated hyperbilirubinemia (HP:0002908)3.34653228
32Hyperglycinuria (HP:0003108)3.33409279
33Hypoglycemic coma (HP:0001325)3.33223767
34Abnormality of serine family amino acid metabolism (HP:0010894)3.30971613
35Abnormality of glycine metabolism (HP:0010895)3.30971613
36Glomerulonephritis (HP:0000099)3.07364817
37Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.01438398
38Hyperbilirubinemia (HP:0002904)3.00558440
39Abnormality of fatty-acid metabolism (HP:0004359)3.00129535
40Steatorrhea (HP:0002570)2.95848904
41Abnormality of nucleobase metabolism (HP:0010932)2.94917753
42Spontaneous abortion (HP:0005268)2.82919337
43Gingival bleeding (HP:0000225)2.81411099
44Skin nodule (HP:0200036)2.80144658
45Hepatocellular carcinoma (HP:0001402)2.74016655
46Amyloidosis (HP:0011034)2.67000936
47Delayed CNS myelination (HP:0002188)2.59192244
48Eczematoid dermatitis (HP:0000976)2.57728722
49Vascular calcification (HP:0004934)2.57019863
50Mitral stenosis (HP:0001718)2.56017926
51Abnormality of purine metabolism (HP:0004352)2.55298891
52Ketoacidosis (HP:0001993)2.53368530
53Abnormality of serum amino acid levels (HP:0003112)2.52126148
54Rickets (HP:0002748)2.47985629
55Hypochromic microcytic anemia (HP:0004840)2.41013889
56Esophageal varix (HP:0002040)2.39185942
57Spastic diplegia (HP:0001264)2.37850857
58Osteomalacia (HP:0002749)2.36546713
59Metabolic acidosis (HP:0001942)2.35840174
60Hemorrhage of the eye (HP:0011885)2.31169400
61Thrombophlebitis (HP:0004418)2.29135568
62Cardiovascular calcification (HP:0011915)2.25988464
63Abnormal gallbladder morphology (HP:0012437)2.24699766
64Abnormality of the Achilles tendon (HP:0005109)2.23528943
65Hypophosphatemic rickets (HP:0004912)2.22559252
66Nephritis (HP:0000123)2.21995801
67Sensorimotor neuropathy (HP:0007141)2.20293542
68Cholelithiasis (HP:0001081)2.20005009
69Dicarboxylic aciduria (HP:0003215)2.19503940
70Abnormality of dicarboxylic acid metabolism (HP:0010995)2.19503940
71Axonal loss (HP:0003447)2.18956672
72Recurrent bacterial skin infections (HP:0005406)2.16554494
73Pancreatitis (HP:0001733)2.15675504
74* Menorrhagia (HP:0000132)2.15519564
75Irritability (HP:0000737)2.14880963
76Lethargy (HP:0001254)2.13198312
77Arthropathy (HP:0003040)2.09443562
78Hypoglycemic seizures (HP:0002173)2.08793291
79Acanthocytosis (HP:0001927)2.08541139
80Pulmonary embolism (HP:0002204)2.07129659
81Enlarged kidneys (HP:0000105)2.05692373
82Neonatal onset (HP:0003623)2.05595039
83Bifid scrotum (HP:0000048)2.03642487
84Abnormality of iron homeostasis (HP:0011031)2.03205520
85Fair hair (HP:0002286)2.01286894
86Abnormal gallbladder physiology (HP:0012438)1.99065480
87Cholecystitis (HP:0001082)1.99065480
88Vacuolated lymphocytes (HP:0001922)1.96083273
89Upper motor neuron abnormality (HP:0002127)1.93958029
90Abnormality of transition element cation homeostasis (HP:0011030)1.92923295
91Gout (HP:0001997)1.92531236
92Opisthotonus (HP:0002179)1.92221413
93Cerebral edema (HP:0002181)1.91400567
94Malnutrition (HP:0004395)1.88622510
95Gangrene (HP:0100758)1.86456181
96Late onset (HP:0003584)1.85483089
97Nausea (HP:0002018)1.85083682
98Generalized aminoaciduria (HP:0002909)1.83994332
99Vomiting (HP:0002013)1.83874868
100Abnormality of the gallbladder (HP:0005264)1.82449520
101Hydroxyprolinuria (HP:0003080)1.81781655
102Abnormality of proline metabolism (HP:0010907)1.81781655
103Abnormal enzyme/coenzyme activity (HP:0012379)1.78949366
104Joint swelling (HP:0001386)1.76138243
105Increased serum ferritin (HP:0003281)1.74925480
106Brushfield spots (HP:0001088)1.73677880
107Purpura (HP:0000979)1.73257635
108Poikilocytosis (HP:0004447)1.72991061
109Recurrent skin infections (HP:0001581)1.72989629
110Neonatal hypoglycemia (HP:0001998)1.71110519
111Asymmetry of the thorax (HP:0001555)1.71050025
112Potter facies (HP:0002009)1.67444377
113Facial shape deformation (HP:0011334)1.67444377
114Reduced antithrombin III activity (HP:0001976)1.66922607
115Elevated alkaline phosphatase (HP:0003155)1.63244157
116Hyperphosphaturia (HP:0003109)1.58857226
117Abnormality of alkaline phosphatase activity (HP:0004379)1.56435035
118Reticulocytosis (HP:0001923)1.51821772
119Abnormality of vitamin metabolism (HP:0100508)1.50721356
120Hypertriglyceridemia (HP:0002155)1.48042683
121Abnormality of urine glucose concentration (HP:0011016)1.44819787
122Glycosuria (HP:0003076)1.44819787
123Retinal atrophy (HP:0001105)1.44242511
124Mucopolysacchariduria (HP:0008155)1.43780026
125Urinary glycosaminoglycan excretion (HP:0003541)1.43780026

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK4.84993122
2ERN14.80318384
3FGFR43.67677400
4SIK13.39634951
5TAOK33.28813469
6ICK2.90575197
7TYK22.68836148
8PKN22.39507790
9MST1R2.30164580
10NTRK32.29359244
11TRIB32.24121150
12MAP3K142.24048025
13MAP4K12.21087092
14FGFR22.13924974
15TBK12.12880639
16ABL22.07372769
17PIK3CA2.07281042
18INSRR2.02420863
19BLK1.98767441
20ERBB41.97306201
21WNK41.95728376
22IRAK31.90566671
23NEK91.89019737
24DAPK21.66876755
25JAK11.60289770
26MAP2K41.58089724
27EPHB11.56457891
28CDK121.52448667
29JAK21.50433780
30FLT31.45445939
31PIK3CG1.41710972
32PTK61.39778931
33CSK1.33977578
34PDGFRA1.33756269
35MAPK111.31020486
36IKBKE1.26194596
37RIPK41.25932884
38IRAK41.23918016
39FGFR11.21999956
40PBK1.20359556
41GRK61.17023057
42TGFBR21.12659139
43KIT1.11163448
44MAP2K31.11031513
45MAP3K101.10473119
46RET1.05428474
47RIPK11.04496625
48CSF1R1.01747214
49EPHA30.99750584
50CAMK1D0.99346779
51SIK20.99125389
52KDR0.99081635
53PRKCG0.98836705
54PRKAA10.97295611
55EPHA40.96263508
56TYRO30.94820134
57BMX0.92578496
58MAPK40.92391805
59IKBKB0.89522350
60MAP3K110.86942622
61MAP3K130.86454781
62CDK60.86439016
63SGK4940.80866462
64SGK2230.80866462
65AKT30.80341201
66MAP2K60.76701331
67MAP3K20.76344497
68JAK30.74519642
69MTOR0.72863382
70ZAP700.71873072
71ERBB20.70064627
72MAP3K70.67993408
73EPHA20.67894286
74SMG10.67891429
75SGK10.66737143
76PRKAA20.66394228
77TNK20.66149918
78PRPF4B0.66111863
79BTK0.65961253
80DDR20.65786169
81MET0.65628890
82PRKCQ0.65548655
83MAPK120.64618813
84HCK0.64086645
85FGFR30.62565890
86PDPK10.60279313
87PRKCZ0.60251828
88PRKACG0.59972589
89PINK10.58765991
90MATK0.58340113
91MAP3K30.58146748
92SYK0.57710695
93WNK10.57549422
94LYN0.56569692
95GSK3A0.56509312
96MUSK0.55649486
97CSNK1D0.55339473
98FRK0.55236058
99RPS6KA60.54855522
100EGFR0.54324236
101RPS6KL10.53637467
102RPS6KC10.53637467
103PDK20.53468133
104PRKG10.53135680
105PRKACA0.52263146
106FGR0.49883261
107CAMK2G0.49717923
108CSNK1E0.48875108
109NLK0.48260420
110ABL10.47853848
111MAP3K50.47358488
112EEF2K0.46193039
113SGK20.46069370
114SRC0.45466794
115PDK10.45258071
116CHUK0.45193210
117RPS6KA30.44448717
118MARK20.44130867
119CDC42BPA0.43909928
120IRAK10.43762969
121IGF1R0.42482071
122MAPKAPK30.42219264
123MAPK70.41827886
124CAMK1G0.41565153
125LATS10.40259758
126MAP3K10.39949261
127CDK40.38983928
128STK380.38913210
129PRKCD0.37932695
130FES0.37578555
131SGK30.36274394
132CDK70.36063213
133MAPK30.35395312
134TAOK20.34380216
135IRAK20.34210419
136DYRK1B0.34051629
137TXK0.33522266
138RPS6KB10.33393037
139MAPK150.33317820
140CSNK2A10.33049677
141STK100.32632877
142CAMKK10.32584622
143MARK30.32564870
144MAP2K20.32333942
145PTK20.31338391
146FER0.30838254
147CSNK2A20.30798460
148PRKCB0.30789284
149NTRK10.30120346
150PRKCH0.29804602
151PIM10.29200029
152LCK0.28956739
153MAP2K10.28955966

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.54052705
2Nitrogen metabolism_Homo sapiens_hsa009103.48397467
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.40573723
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.26103691
5* Complement and coagulation cascades_Homo sapiens_hsa046103.10701697
6Arginine biosynthesis_Homo sapiens_hsa002203.08124776
7Tryptophan metabolism_Homo sapiens_hsa003802.58330345
8Staphylococcus aureus infection_Homo sapiens_hsa051502.57102923
9Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.54890046
10Pentose and glucuronate interconversions_Homo sapiens_hsa000402.46725265
11Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.39796851
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.36635831
13Fatty acid degradation_Homo sapiens_hsa000712.36278873
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.19598918
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.10822588
16Histidine metabolism_Homo sapiens_hsa003402.03628088
17Peroxisome_Homo sapiens_hsa041462.02574927
18Chemical carcinogenesis_Homo sapiens_hsa052041.93360910
19Caffeine metabolism_Homo sapiens_hsa002321.92254297
20Steroid hormone biosynthesis_Homo sapiens_hsa001401.91055058
21Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.90845959
22Butanoate metabolism_Homo sapiens_hsa006501.89389869
23PPAR signaling pathway_Homo sapiens_hsa033201.88937498
24Drug metabolism - other enzymes_Homo sapiens_hsa009831.79582825
25beta-Alanine metabolism_Homo sapiens_hsa004101.71408444
26Retinol metabolism_Homo sapiens_hsa008301.65702503
27Propanoate metabolism_Homo sapiens_hsa006401.65635459
28Fatty acid metabolism_Homo sapiens_hsa012121.64759972
29Phenylalanine metabolism_Homo sapiens_hsa003601.54814793
30Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.54123422
31Selenocompound metabolism_Homo sapiens_hsa004501.48662655
32Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.45572742
33Bile secretion_Homo sapiens_hsa049761.41449438
34Starch and sucrose metabolism_Homo sapiens_hsa005001.38077974
35Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.36524919
36Tyrosine metabolism_Homo sapiens_hsa003501.34087446
37Steroid biosynthesis_Homo sapiens_hsa001001.32463528
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.29561496
392-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.28997586
40ABC transporters_Homo sapiens_hsa020101.26859356
41Sulfur metabolism_Homo sapiens_hsa009201.19312298
42Folate biosynthesis_Homo sapiens_hsa007901.16495989
43Fatty acid elongation_Homo sapiens_hsa000621.15859402
44Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.11987779
45Pyruvate metabolism_Homo sapiens_hsa006201.11092846
46Cysteine and methionine metabolism_Homo sapiens_hsa002701.08619917
47Biosynthesis of amino acids_Homo sapiens_hsa012301.08046370
48Fat digestion and absorption_Homo sapiens_hsa049751.06242291
49Carbon metabolism_Homo sapiens_hsa012001.01172133
50Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.98542616
51Arachidonic acid metabolism_Homo sapiens_hsa005900.95700365
52Sulfur relay system_Homo sapiens_hsa041220.92443312
53Arginine and proline metabolism_Homo sapiens_hsa003300.88942508
54Vitamin digestion and absorption_Homo sapiens_hsa049770.81169772
55Maturity onset diabetes of the young_Homo sapiens_hsa049500.77022960
56Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.74699492
57Lysine degradation_Homo sapiens_hsa003100.73924201
58Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.72089277
59Cyanoamino acid metabolism_Homo sapiens_hsa004600.71210989
60Vitamin B6 metabolism_Homo sapiens_hsa007500.68468853
61Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.67418759
62Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.65077319
63Glycerolipid metabolism_Homo sapiens_hsa005610.64182378
64One carbon pool by folate_Homo sapiens_hsa006700.64044307
65Pentose phosphate pathway_Homo sapiens_hsa000300.64005388
66Glutathione metabolism_Homo sapiens_hsa004800.58987284
67Prion diseases_Homo sapiens_hsa050200.43227795
68Glycosaminoglycan degradation_Homo sapiens_hsa005310.40663560
69Fatty acid biosynthesis_Homo sapiens_hsa000610.38123597
70Metabolic pathways_Homo sapiens_hsa011000.37780893
71Adipocytokine signaling pathway_Homo sapiens_hsa049200.32797860
72Lysosome_Homo sapiens_hsa041420.31319116
73Insulin resistance_Homo sapiens_hsa049310.29432860
74Galactose metabolism_Homo sapiens_hsa000520.28669531
75Pertussis_Homo sapiens_hsa051330.24034646
76Fructose and mannose metabolism_Homo sapiens_hsa000510.23701183
77Leishmaniasis_Homo sapiens_hsa051400.20941079
78Linoleic acid metabolism_Homo sapiens_hsa005910.17469958
79Other glycan degradation_Homo sapiens_hsa005110.16867381
80alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.16828379
81Malaria_Homo sapiens_hsa051440.16605643
82Legionellosis_Homo sapiens_hsa051340.15920984
83Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.15637401
84Systemic lupus erythematosus_Homo sapiens_hsa053220.15111026
85Renin-angiotensin system_Homo sapiens_hsa046140.14286621
86Toll-like receptor signaling pathway_Homo sapiens_hsa046200.10836454
87Glycerophospholipid metabolism_Homo sapiens_hsa005640.10092672
88RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.09747805
89Tuberculosis_Homo sapiens_hsa051520.09724744
90Phagosome_Homo sapiens_hsa041450.09630227
91Mineral absorption_Homo sapiens_hsa049780.07816325
92African trypanosomiasis_Homo sapiens_hsa051430.05008710
93Carbohydrate digestion and absorption_Homo sapiens_hsa049730.02662996
94Sphingolipid metabolism_Homo sapiens_hsa006000.00485501
95Type II diabetes mellitus_Homo sapiens_hsa04930-0.2069363
96Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1848660
97ECM-receptor interaction_Homo sapiens_hsa04512-0.1763731
98Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1738455
99Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1545798
100Serotonergic synapse_Homo sapiens_hsa04726-0.1309181
101Circadian rhythm_Homo sapiens_hsa04710-0.1032263
102Rheumatoid arthritis_Homo sapiens_hsa05323-0.0811072
103Intestinal immune network for IgA production_Homo sapiens_hsa04672-0.0785695
104AMPK signaling pathway_Homo sapiens_hsa04152-0.0718892
105Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0569469
106Amoebiasis_Homo sapiens_hsa05146-0.0437859
107N-Glycan biosynthesis_Homo sapiens_hsa00510-0.0435466
108NF-kappa B signaling pathway_Homo sapiens_hsa04064-0.0400450
109Glucagon signaling pathway_Homo sapiens_hsa04922-0.0368894
110Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.0323467
111Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0301515
112Terpenoid backbone biosynthesis_Homo sapiens_hsa00900-0.0284418
113Thyroid hormone synthesis_Homo sapiens_hsa04918-0.0156151
114Hepatitis C_Homo sapiens_hsa05160-0.0124095
115Osteoclast differentiation_Homo sapiens_hsa04380-0.0023795
116Insulin signaling pathway_Homo sapiens_hsa04910-0.0023471

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