F8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)6.86544975
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.86544975
3muscle filament sliding (GO:0030049)6.80493874
4actin-myosin filament sliding (GO:0033275)6.80493874
5positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)6.77795570
6L-phenylalanine metabolic process (GO:0006558)6.46049846
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.46049846
8sarcoplasmic reticulum calcium ion transport (GO:0070296)6.45597222
9regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO6.33966744
10regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)6.24856723
11aromatic amino acid family catabolic process (GO:0009074)6.19116105
12cardiac myofibril assembly (GO:0055003)6.09306769
13sarcomere organization (GO:0045214)6.05719009
14myofibril assembly (GO:0030239)5.96909025
15cardiac muscle contraction (GO:0060048)5.81338351
16regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)5.79587424
17triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.73510005
18actin-mediated cell contraction (GO:0070252)5.69562620
19regulation of actin filament-based movement (GO:1903115)5.60320804
20indole-containing compound catabolic process (GO:0042436)5.56513906
21indolalkylamine catabolic process (GO:0046218)5.56513906
22tryptophan catabolic process (GO:0006569)5.56513906
23regulation of relaxation of muscle (GO:1901077)5.51709693
24tryptophan metabolic process (GO:0006568)5.43576839
25bile acid biosynthetic process (GO:0006699)5.41762500
26negative regulation of fibrinolysis (GO:0051918)5.36970647
27alpha-linolenic acid metabolic process (GO:0036109)5.30642961
28kynurenine metabolic process (GO:0070189)5.28320331
29high-density lipoprotein particle remodeling (GO:0034375)5.27487796
30glyoxylate metabolic process (GO:0046487)5.17419590
31protein carboxylation (GO:0018214)5.17276633
32peptidyl-glutamic acid carboxylation (GO:0017187)5.17276633
33urea cycle (GO:0000050)5.14515149
34urea metabolic process (GO:0019627)5.14515149
35regulation of fibrinolysis (GO:0051917)5.07312323
36regulation of cell communication by electrical coupling (GO:0010649)5.04831924
37regulation of protein activation cascade (GO:2000257)5.00943607
38cardiac muscle hypertrophy (GO:0003300)4.99587060
39complement activation, alternative pathway (GO:0006957)4.98959496
40sulfur amino acid catabolic process (GO:0000098)4.94163899
41cellular response to epinephrine stimulus (GO:0071872)4.93202026
42regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.90287651
43reverse cholesterol transport (GO:0043691)4.89128873
44striated muscle contraction (GO:0006941)4.88780523
45striated muscle hypertrophy (GO:0014897)4.81904436
46response to epinephrine (GO:0071871)4.76374286
47nitrogen cycle metabolic process (GO:0071941)4.70575151
48regulation of complement activation (GO:0030449)4.69149644
49carnitine shuttle (GO:0006853)4.68290062
50bile acid metabolic process (GO:0008206)4.63287071
51cysteine metabolic process (GO:0006534)4.62770458
52tyrosine metabolic process (GO:0006570)4.60532316
53amino-acid betaine metabolic process (GO:0006577)4.59435721
54NADH metabolic process (GO:0006734)4.57460760
55protein-lipid complex remodeling (GO:0034368)4.57259899
56macromolecular complex remodeling (GO:0034367)4.57259899
57plasma lipoprotein particle remodeling (GO:0034369)4.57259899
58fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.55770258
59homocysteine metabolic process (GO:0050667)4.54798984
60aromatic amino acid family metabolic process (GO:0009072)4.50196792
61acylglycerol homeostasis (GO:0055090)4.47747472
62triglyceride homeostasis (GO:0070328)4.47747472
63serine family amino acid catabolic process (GO:0009071)4.47448467
64actomyosin structure organization (GO:0031032)4.43770950
65phospholipid efflux (GO:0033700)4.42174726
66muscle hypertrophy (GO:0014896)4.39465545
67phospholipid homeostasis (GO:0055091)4.38794389
68cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.37648297
69regulation of cholesterol esterification (GO:0010872)4.37411451
70response to stimulus involved in regulation of muscle adaptation (GO:0014874)4.35501281
71regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.33391133
72positive regulation of fatty acid beta-oxidation (GO:0032000)4.32904214
73fatty acid transmembrane transport (GO:1902001)4.31373420
74heart process (GO:0003015)4.29858986
75heart contraction (GO:0060047)4.29858986
76actin filament-based movement (GO:0030048)4.28649228
77negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.20616223
78regulation of triglyceride catabolic process (GO:0010896)4.17340035
79positive regulation of calcium ion transmembrane transporter activity (GO:1901021)4.16093623
80indolalkylamine metabolic process (GO:0006586)4.15540618
81low-density lipoprotein particle remodeling (GO:0034374)4.14745890
82plasma lipoprotein particle clearance (GO:0034381)4.14630937
83regulation of sarcomere organization (GO:0060297)4.14336464
84bile acid and bile salt transport (GO:0015721)4.14197130
85regulation of skeletal muscle contraction (GO:0014819)4.13797480
86alpha-amino acid catabolic process (GO:1901606)4.11389933
87detection of calcium ion (GO:0005513)4.09332788
88regulation of striated muscle contraction (GO:0006942)4.06518787
89lysine metabolic process (GO:0006553)4.03634681
90lysine catabolic process (GO:0006554)4.03634681
91cholesterol efflux (GO:0033344)4.00824057
92cardiac muscle tissue morphogenesis (GO:0055008)4.00281646
93negative regulation of cholesterol transport (GO:0032375)3.96389694
94negative regulation of sterol transport (GO:0032372)3.96389694
95ventricular cardiac muscle cell action potential (GO:0086005)3.94722685
96imidazole-containing compound metabolic process (GO:0052803)3.92014941
97positive regulation of lipid catabolic process (GO:0050996)3.91554391
98cellular glucuronidation (GO:0052695)3.91457629
99coenzyme catabolic process (GO:0009109)3.89413584
100regulation of cardiac muscle cell contraction (GO:0086004)3.87384295
101benzene-containing compound metabolic process (GO:0042537)3.86456152
102creatine metabolic process (GO:0006600)3.86115398
103cellular biogenic amine catabolic process (GO:0042402)3.84314016
104amine catabolic process (GO:0009310)3.84314016
105plasma lipoprotein particle assembly (GO:0034377)3.82110055
106negative regulation of potassium ion transmembrane transport (GO:1901380)3.80559488
107cellular amino acid catabolic process (GO:0009063)3.78704346
108ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.77092553
109cell communication involved in cardiac conduction (GO:0086065)3.77003428
110muscle tissue morphogenesis (GO:0060415)3.72929543
111carnitine metabolic process (GO:0009437)3.71868219
112fibrinolysis (GO:0042730)3.71794540
113positive regulation of triglyceride lipase activity (GO:0061365)3.71064347
114positive regulation of lipoprotein lipase activity (GO:0051006)3.71064347
115cellular ketone body metabolic process (GO:0046950)3.70394121
116skeletal muscle contraction (GO:0003009)3.69966593
117regulation of the force of heart contraction (GO:0002026)3.69733105
118membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.68663611
119aldehyde catabolic process (GO:0046185)3.68502390
120cardiac muscle cell development (GO:0055013)3.67485073
121drug catabolic process (GO:0042737)3.67351881
122glycine metabolic process (GO:0006544)3.66164246
123* protein activation cascade (GO:0072376)3.60659229
124muscle contraction (GO:0006936)3.58329569
125cellular modified amino acid catabolic process (GO:0042219)3.57800454
126plasma lipoprotein particle organization (GO:0071827)3.57404048
127regulation of sequestering of triglyceride (GO:0010889)3.57166139
128uronic acid metabolic process (GO:0006063)3.55568580
129glucuronate metabolic process (GO:0019585)3.55568580
130cholesterol homeostasis (GO:0042632)3.54996327
131cardiac muscle adaptation (GO:0014887)3.52451690
132cardiac muscle hypertrophy in response to stress (GO:0014898)3.52451690
133muscle hypertrophy in response to stress (GO:0003299)3.52451690
134carnitine transmembrane transport (GO:1902603)3.52399529
135glutamate metabolic process (GO:0006536)3.51186309
136lipoprotein metabolic process (GO:0042157)3.50796838
137ethanol oxidation (GO:0006069)3.50482376
138sterol homeostasis (GO:0055092)3.49990350
139* blood coagulation, intrinsic pathway (GO:0007597)3.49942859
140negative regulation of lipase activity (GO:0060192)3.49834965
141arginine metabolic process (GO:0006525)3.49704089
142regulation of fatty acid beta-oxidation (GO:0031998)3.49412903
143positive regulation of fatty acid oxidation (GO:0046321)3.47712100
144negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.46555526
145cofactor catabolic process (GO:0051187)3.45727610
146serine family amino acid metabolic process (GO:0009069)3.45568228
147regulation of cholesterol biosynthetic process (GO:0045540)3.43804723
148cell communication by electrical coupling (GO:0010644)3.43583491
149fatty acid oxidation (GO:0019395)3.43170552
150organic acid catabolic process (GO:0016054)3.42167595
151carboxylic acid catabolic process (GO:0046395)3.42167595
152regulation of membrane repolarization (GO:0060306)3.41532687
153fatty acid beta-oxidation (GO:0006635)3.40888554
154cardiac cell development (GO:0055006)3.40433339
155complement activation (GO:0006956)3.40151603
156response to nitrosative stress (GO:0051409)3.39726358
157lipid oxidation (GO:0034440)3.38073283
158regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.37934322
159very-low-density lipoprotein particle assembly (GO:0034379)3.37885762
160complement activation, classical pathway (GO:0006958)3.36960414
161protein-lipid complex assembly (GO:0065005)3.35984098
162regulation of cardiac muscle contraction (GO:0055117)3.35293768
163regulation of calcium ion transmembrane transport (GO:1903169)3.34736844
164regulation of calcium ion transmembrane transporter activity (GO:1901019)3.34736844
165muscle system process (GO:0003012)3.32603569
166striated muscle adaptation (GO:0014888)3.26014318
167response to inactivity (GO:0014854)3.24892448
168skeletal muscle adaptation (GO:0043501)3.20811906
169amino-acid betaine transport (GO:0015838)3.19427970
170carnitine transport (GO:0015879)3.19427970
1712-oxoglutarate metabolic process (GO:0006103)3.19279902
172regulation of heart rate (GO:0002027)3.16960992
173negative regulation of calcium ion transmembrane transport (GO:1903170)3.16646000
174negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.16646000
175relaxation of cardiac muscle (GO:0055119)3.14663110
176cardiac muscle cell action potential (GO:0086001)3.09745328
177adult heart development (GO:0007512)3.03418272
178negative regulation of protein localization to cell surface (GO:2000009)2.99897361
179regulation of heart contraction (GO:0008016)2.98520658
180relaxation of muscle (GO:0090075)2.97809689
181intracellular lipid transport (GO:0032365)2.94873509
182cGMP-mediated signaling (GO:0019934)2.94134775
183positive regulation of cation channel activity (GO:2001259)2.93897013
184cardiac muscle cell action potential involved in contraction (GO:0086002)2.93763667
185adrenergic receptor signaling pathway (GO:0071875)2.93084534
186positive regulation of heart rate (GO:0010460)2.92034073
187regulation of muscle system process (GO:0090257)2.87286084
188regulation of muscle contraction (GO:0006937)2.85702657
189tricarboxylic acid cycle (GO:0006099)2.79296511
190glycogen catabolic process (GO:0005980)2.78796564
191activation of protein kinase A activity (GO:0034199)2.78774808
192regulation of ATPase activity (GO:0043462)2.77903338
193regulation of ATP catabolic process (GO:1903289)2.77903338
194response to caffeine (GO:0031000)2.77746537
195regulation of lipoprotein metabolic process (GO:0050746)2.71958786
196oxaloacetate metabolic process (GO:0006107)2.71772576
197calcium-mediated signaling using intracellular calcium source (GO:0035584)2.71673205
198regulation of cation channel activity (GO:2001257)2.71518695
199muscle adaptation (GO:0043500)2.71066984

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse7.36244507
2PPARA_22158963_ChIP-Seq_LIVER_Mouse6.25045373
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.18978950
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.08755291
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.13357763
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.29726356
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.25251390
8EZH2_22144423_ChIP-Seq_EOC_Human3.99929233
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.80612976
10RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.46253764
11CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.24644817
12SMAD_19615063_ChIP-ChIP_OVARY_Human2.71065150
13TBX20_22328084_ChIP-Seq_HEART_Mouse2.53334541
14TBX20_22080862_ChIP-Seq_HEART_Mouse2.53334541
15GBX2_23144817_ChIP-Seq_PC3_Human2.36664232
16BP1_19119308_ChIP-ChIP_Hs578T_Human2.11945525
17ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.3721328
18CLOCK_20551151_ChIP-Seq_293T_Human1.93438593
19GATA1_22025678_ChIP-Seq_K562_Human1.92788918
20TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.70461775
21IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.69211395
22STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.68394104
23FOXA2_19822575_ChIP-Seq_HepG2_Human1.65928903
24TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.65209759
25HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.62668362
26FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.59534105
27IRF8_22096565_ChIP-ChIP_GC-B_Human1.56555516
28MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.52197690
29HTT_18923047_ChIP-ChIP_STHdh_Human1.47419198
30CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.41396582
31GATA4_21415370_ChIP-Seq_HL-1_Mouse1.41126020
32GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36768250
33SMAD4_21799915_ChIP-Seq_A2780_Human1.36113744
34SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.35306722
35PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.33999019
36BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.28537253
37HNF4A_19822575_ChIP-Seq_HepG2_Human1.24511473
38ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.23025872
39GATA2_21666600_ChIP-Seq_HMVEC_Human1.22694391
40SUZ12_27294783_Chip-Seq_NPCs_Mouse1.22519745
41POU3F2_20337985_ChIP-ChIP_501MEL_Human1.20785841
42ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.20611335
43SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20243167
44PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.19983976
45PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.18300309
46VDR_22108803_ChIP-Seq_LS180_Human1.09345328
47Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.08456530
48CTNNB1_20460455_ChIP-Seq_HCT116_Human1.08384336
49FLI1_27457419_Chip-Seq_LIVER_Mouse1.07436695
50TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.07333491
51NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.06703057
52NRF2_20460467_ChIP-Seq_MEFs_Mouse1.06703057
53THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.04914003
54ESR1_20079471_ChIP-ChIP_T-47D_Human1.04884289
55SALL4_18804426_ChIP-ChIP_XEN_Mouse1.04866934
56NFE2_27457419_Chip-Seq_LIVER_Mouse1.04635556
57IGF1R_20145208_ChIP-Seq_DFB_Human1.04590815
58CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.04506266
59MTF2_20144788_ChIP-Seq_MESCs_Mouse1.02792688
60SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.02218914
61EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.02130760
62TRIM28_21343339_ChIP-Seq_HEK293_Human1.00232495
63OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99860825
64PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.99337124
65OCT4_21477851_ChIP-Seq_ESCs_Mouse0.98931742
66NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.98827514
67SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.98775148
68SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.98386397
69PCGF2_27294783_Chip-Seq_ESCs_Mouse0.98130892
70SOX2_21211035_ChIP-Seq_LN229_Gbm0.98087707
71SOX2_27498859_Chip-Seq_STOMACH_Mouse0.97635619
72* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.97540448
73PCGF2_27294783_Chip-Seq_NPCs_Mouse0.97512732
74NR3C1_21868756_ChIP-Seq_MCF10A_Human0.97236739
75CRX_20693478_ChIP-Seq_RETINA_Mouse0.97080224
76FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.96835801
77EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.95756492
78NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.95186769
79SMAD3_21741376_ChIP-Seq_HESCs_Human0.94933057
80ESR1_21235772_ChIP-Seq_MCF-7_Human0.94635976
81GATA1_19941827_ChIP-Seq_MEL86_Mouse0.94298849
82WT1_25993318_ChIP-Seq_PODOCYTE_Human0.94112404
83LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.93662203
84PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.93654533
85STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.93440739
86RXRA_24833708_ChIP-Seq_LIVER_Mouse0.93059921
87FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.92498406
88SOX9_24532713_ChIP-Seq_HFSC_Mouse0.91881756
89SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.91370194
90ESR2_21235772_ChIP-Seq_MCF-7_Human0.90997914
91MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.89959827
92STAT3_23295773_ChIP-Seq_U87_Human0.89478150
93TCF4_23295773_ChIP-Seq_U87_Human0.88953488
94GATA4_25053715_ChIP-Seq_YYC3_Human0.88612179
95ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.87837793
96ZFP57_27257070_Chip-Seq_ESCs_Mouse0.86936230
97CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.86802365
98GATA1_19941826_ChIP-Seq_K562_Human0.82098641
99RARG_19884340_ChIP-ChIP_MEFs_Mouse0.82017416
100AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.80805248
101AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.77805274
102FOXO3_23340844_ChIP-Seq_DLD1_Human0.76246463
103ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.76199003
104PIAS1_25552417_ChIP-Seq_VCAP_Human0.75741222
105ZNF217_24962896_ChIP-Seq_MCF-7_Human0.74005170
106PPAR_26484153_Chip-Seq_NCI-H1993_Human0.73941163
107SOX2_20726797_ChIP-Seq_SW620_Human0.73685457
108FOXA1_25552417_ChIP-Seq_VCAP_Human0.73277963
109AUTS2_25519132_ChIP-Seq_293T-REX_Human0.69816413
110BCAT_22108803_ChIP-Seq_LS180_Human0.69779735
111FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.69534257
112PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.68763125
113TAF15_26573619_Chip-Seq_HEK293_Human0.68089321
114GATA2_19941826_ChIP-Seq_K562_Human0.67825733
115FOXM1_26456572_ChIP-Seq_MCF-7_Human0.65432797
116CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.65165657
117ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.63977757
118PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.62271235
119SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.59900030
120TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.59519945
121FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.58375981
122NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.58068203
123TP63_23658742_ChIP-Seq_EP156T_Human0.56415793
124AR_20517297_ChIP-Seq_VCAP_Human0.56081538
125EP300_21415370_ChIP-Seq_HL-1_Mouse0.54269448
126BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.53364128
127RARA_24833708_ChIP-Seq_LIVER_Mouse0.52604409
128CDX2_22108803_ChIP-Seq_LS180_Human0.52314718
129SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.51457605
130CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.50955293
131KAP1_22055183_ChIP-Seq_ESCs_Mouse0.50390016
132STAT1_17558387_ChIP-Seq_HELA_Human0.50318139
133PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.48497056
134* CJUN_26792858_Chip-Seq_BT549_Human0.48071625
135GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.47578967
136NFIB_24661679_ChIP-Seq_LUNG_Mouse0.47522522
137CDX2_19796622_ChIP-Seq_MESCs_Mouse0.47371047
138FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.47148344
139FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.46848154
140ZNF263_19887448_ChIP-Seq_K562_Human0.46222791
141RXR_22108803_ChIP-Seq_LS180_Human0.45615881
142SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.45061599
143NR3C1_23031785_ChIP-Seq_PC12_Mouse0.44815654
144EGR1_19032775_ChIP-ChIP_M12_Human0.44677921
145IRF8_27001747_Chip-Seq_BMDM_Mouse0.44647409
146EZH2_27294783_Chip-Seq_NPCs_Mouse0.44578785
147TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.44500235
148GATA1_19941827_ChIP-Seq_MEL_Mouse0.43891844
149CDX2_20551321_ChIP-Seq_CACO-2_Human0.43731267
150ESET_19884257_ChIP-Seq_ESCs_Mouse0.43270996
151NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.42756611
152CBP_21632823_ChIP-Seq_H3396_Human0.41722796

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.81733235
2MP0005360_urolithiasis6.57417701
3MP0005085_abnormal_gallbladder_physiolo5.96902839
4MP0005365_abnormal_bile_salt5.79421353
5MP0004084_abnormal_cardiac_muscle5.31399896
6MP0000751_myopathy5.25801271
7MP0004036_abnormal_muscle_relaxation4.30491025
8MP0008875_abnormal_xenobiotic_pharmacok4.27908528
9MP0004215_abnormal_myocardial_fiber4.17447039
10MP0003252_abnormal_bile_duct3.75603583
11MP0003646_muscle_fatigue3.59357205
12MP0010368_abnormal_lymphatic_system3.44688446
13MP0000749_muscle_degeneration3.44316795
14MP0010329_abnormal_lipoprotein_level3.44140075
15MP0003806_abnormal_nucleotide_metabolis3.36165497
16MP0004510_myositis3.27295463
17MP0005330_cardiomyopathy3.12370349
18MP0003195_calcinosis2.83524280
19MP0004087_abnormal_muscle_fiber2.80194517
20MP0006138_congestive_heart_failure2.78544570
21MP0002972_abnormal_cardiac_muscle2.72725802
22MP0004145_abnormal_muscle_electrophysio2.69565436
23MP0003724_increased_susceptibility_to2.59005684
24MP0005083_abnormal_biliary_tract2.57839288
25MP0004484_altered_response_of2.57436804
26MP0009840_abnormal_foam_cell2.55872315
27MP0005620_abnormal_muscle_contractility2.45482193
28MP0005332_abnormal_amino_acid2.43943135
29MP0000013_abnormal_adipose_tissue2.35299443
30MP0003191_abnormal_cellular_cholesterol2.33871925
31MP0002138_abnormal_hepatobiliary_system2.29619922
32MP0002106_abnormal_muscle_physiology2.28135500
33MP0001544_abnormal_cardiovascular_syste2.27393151
34MP0005385_cardiovascular_system_phenoty2.27393151
35MP0001666_abnormal_nutrient_absorption2.16819823
36MP0000609_abnormal_liver_physiology2.16025319
37MP0002269_muscular_atrophy2.14633392
38MP0000747_muscle_weakness2.12409702
39MP0003137_abnormal_impulse_conducting2.10618007
40MP0003828_pulmonary_edema2.09534073
41MP0004019_abnormal_vitamin_homeostasis2.08245765
42MP0008775_abnormal_heart_ventricle2.07429786
43MP0002118_abnormal_lipid_homeostasis2.01193535
44MP0010630_abnormal_cardiac_muscle2.00924113
45MP0002332_abnormal_exercise_endurance1.99582071
46MP0000759_abnormal_skeletal_muscle1.92950608
47MP0005369_muscle_phenotype1.91983067
48MP0002127_abnormal_cardiovascular_syste1.91208250
49MP0000750_abnormal_muscle_regeneration1.83450687
50MP0004085_abnormal_heartbeat1.70902147
51MP0003868_abnormal_feces_composition1.69536981
52MP0005319_abnormal_enzyme/_coenzyme1.66521622
53MP0001879_abnormal_lymphatic_vessel1.63800347
54MP0005165_increased_susceptibility_to1.61081899
55MP0009697_abnormal_copulation1.51148216
56MP0000343_altered_response_to1.51004330
57MP0001764_abnormal_homeostasis1.49598947
58MP0002254_reproductive_system_inflammat1.38522637
59MP0005584_abnormal_enzyme/coenzyme_acti1.38388577
60MP0003221_abnormal_cardiomyocyte_apopto1.33589734
61MP0009643_abnormal_urine_homeostasis1.33407259
62MP0004233_abnormal_muscle_weight1.32547666
63MP0003300_gastrointestinal_ulcer1.31595729
64MP0003186_abnormal_redox_activity1.28583778
65MP0002108_abnormal_muscle_morphology1.26639670
66MP0006054_spinal_hemorrhage1.22040098
67MP0003045_fibrosis1.19921451
68MP0009763_increased_sensitivity_to1.15641973
69MP0000598_abnormal_liver_morphology1.15372812
70MP0003705_abnormal_hypodermis_morpholog1.13443664
71MP0009764_decreased_sensitivity_to1.12538051
72MP0003950_abnormal_plasma_membrane1.12326244
73MP0001661_extended_life_span1.03425904
74MP0003011_delayed_dark_adaptation1.02273477
75MP0004130_abnormal_muscle_cell1.02156238
76MP0005670_abnormal_white_adipose1.01582592
77MP0002078_abnormal_glucose_homeostasis0.99287557
78MP0009780_abnormal_chondrocyte_physiolo0.99118165
79MP0003656_abnormal_erythrocyte_physiolo0.98448398
80MP0005647_abnormal_sex_gland0.97954855
81MP0008469_abnormal_protein_level0.97826656
82MP0005408_hypopigmentation0.97064727
83MP0005636_abnormal_mineral_homeostasis0.96392336
84MP0001958_emphysema0.91334259
85MP0003690_abnormal_glial_cell0.89633478
86MP0005275_abnormal_skin_tensile0.89325687
87MP0002877_abnormal_melanocyte_morpholog0.88400910
88MP0000003_abnormal_adipose_tissue0.87257424
89MP0009642_abnormal_blood_homeostasis0.84995092
90MP0000604_amyloidosis0.84820394
91MP0005220_abnormal_exocrine_pancreas0.83664338
92MP0008004_abnormal_stomach_pH0.83308780
93MP0000266_abnormal_heart_morphology0.80617809
94MP0008438_abnormal_cutaneous_collagen0.80539005
95MP0000733_abnormal_muscle_development0.79628423
96MP0009115_abnormal_fat_cell0.79196330
97MP0005451_abnormal_body_composition0.77321795
98MP0001756_abnormal_urination0.75835139
99MP0004185_abnormal_adipocyte_glucose0.75576830
100MP0009765_abnormal_xenobiotic_induced0.75212239
101MP0002128_abnormal_blood_circulation0.74742886
102MP0005535_abnormal_body_temperature0.71962628
103MP0002876_abnormal_thyroid_physiology0.70125894
104MP0002928_abnormal_bile_duct0.69641364
105MP0005334_abnormal_fat_pad0.69419534
106MP0005084_abnormal_gallbladder_morpholo0.67691120
107MP0005376_homeostasis/metabolism_phenot0.67456717
108MP0003566_abnormal_cell_adhesion0.66368405
109MP0005666_abnormal_adipose_tissue0.64740182
110MP0005167_abnormal_blood-brain_barrier0.62756691
111MP0002971_abnormal_brown_adipose0.59722622
112MP0004782_abnormal_surfactant_physiolog0.56907188
113MP0002295_abnormal_pulmonary_circulatio0.55331912
114MP0003075_altered_response_to0.54903991
115MP0003279_aneurysm0.53194320
116MP0000639_abnormal_adrenal_gland0.53078116
117MP0004270_analgesia0.51164492
118MP0004272_abnormal_basement_membrane0.50815983
119MP0004147_increased_porphyrin_level0.50382769
120MP0001984_abnormal_olfaction0.50139021
121MP0006036_abnormal_mitochondrial_physio0.49610256
122MP0002136_abnormal_kidney_physiology0.49522763
123MP0001851_eye_inflammation0.49513134
124MP0001944_abnormal_pancreas_morphology0.49081009
125MP0005375_adipose_tissue_phenotype0.48563292
126MP0003879_abnormal_hair_cell0.48506805
127MP0000920_abnormal_myelination0.48258685
128MP0001243_abnormal_dermal_layer0.48178796
129MP0004043_abnormal_pH_regulation0.48138716
130MP0000230_abnormal_systemic_arterial0.47637035
131MP0005058_abnormal_lysosome_morphology0.46731756
132MP0005464_abnormal_platelet_physiology0.46204744
133MP0005448_abnormal_energy_balance0.45454903
134MP0002168_other_aberrant_phenotype0.45314394
135MP0002998_abnormal_bone_remodeling0.45243421
136MP0000767_abnormal_smooth_muscle0.45211763
137MP0003953_abnormal_hormone_level0.45142581
138MP0004264_abnormal_extraembryonic_tissu0.44827964
139MP0002133_abnormal_respiratory_system0.44694166
140MP0005388_respiratory_system_phenotype0.44694166
141MP0005164_abnormal_response_to0.44556692
142MP0005166_decreased_susceptibility_to0.44053121
143MP0000249_abnormal_blood_vessel0.43693798
144MP0001915_intracranial_hemorrhage0.43162406
145MP0005503_abnormal_tendon_morphology0.42862279
146MP0003091_abnormal_cell_migration0.40247870
147MP0001845_abnormal_inflammatory_respons0.38870688
148MP0002837_dystrophic_cardiac_calcinosis0.38833549
149MP0005595_abnormal_vascular_smooth0.36375033
150MP0008874_decreased_physiological_sensi0.35612447
151MP0002693_abnormal_pancreas_physiology0.35567135
152MP0006082_CNS_inflammation0.35400412
153MP0004381_abnormal_hair_follicle0.34793205
154MP0005266_abnormal_metabolism0.34641824
155MP0004883_abnormal_blood_vessel0.34628001
156MP0002060_abnormal_skin_morphology0.34197161
157MP0005395_other_phenotype0.33802473
158MP0002419_abnormal_innate_immunity0.33490879
159MP0001533_abnormal_skeleton_physiology0.33484138

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.44730716
2Intrahepatic cholestasis (HP:0001406)7.13421914
3Sudden death (HP:0001699)6.89952703
4Bundle branch block (HP:0011710)6.62570798
5* Prolonged partial thromboplastin time (HP:0003645)6.58429120
6Abnormality of aromatic amino acid family metabolism (HP:0004338)6.44811324
7Abnormality of monocarboxylic acid metabolism (HP:0010996)6.27243542
8Xanthomatosis (HP:0000991)5.95967879
9Muscle fiber splitting (HP:0003555)5.83704213
10Muscle fiber inclusion bodies (HP:0100299)5.82522524
11Hyporeflexia of lower limbs (HP:0002600)5.79273282
12Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)5.73481682
13Nemaline bodies (HP:0003798)5.69589965
14Hypobetalipoproteinemia (HP:0003563)5.56791017
15Exercise-induced myalgia (HP:0003738)5.34453522
16Hyperlipoproteinemia (HP:0010980)5.15066689
17Type 1 muscle fiber predominance (HP:0003803)5.09574321
18Ventricular tachycardia (HP:0004756)5.06403927
19Complement deficiency (HP:0004431)4.94614529
20Abnormality of the calf musculature (HP:0001430)4.93376689
21* Joint hemorrhage (HP:0005261)4.82257986
22EMG: myopathic abnormalities (HP:0003458)4.73021206
23Exercise-induced muscle cramps (HP:0003710)4.58810410
24Asymmetric septal hypertrophy (HP:0001670)4.56783093
25Atrial fibrillation (HP:0005110)4.56088716
26Syncope (HP:0001279)4.53929471
27Calf muscle hypertrophy (HP:0008981)4.51569434
28Hypolipoproteinemia (HP:0010981)4.49292614
29Epidermoid cyst (HP:0200040)4.49115189
30Lipoatrophy (HP:0100578)4.48094866
31Muscle hypertrophy of the lower extremities (HP:0008968)4.47890358
32Abnormality of the common coagulation pathway (HP:0010990)4.42700104
33Hyperammonemia (HP:0001987)4.39039233
34Heart block (HP:0012722)4.31872642
35Hypoglycemic coma (HP:0001325)4.31305882
36Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.24372997
37Hypoalphalipoproteinemia (HP:0003233)4.20766137
38Right ventricular cardiomyopathy (HP:0011663)4.17851637
39Abnormal atrioventricular conduction (HP:0005150)4.17829006
40Primary atrial arrhythmia (HP:0001692)4.12441148
41Hyperglycinemia (HP:0002154)4.08313692
42Myoglobinuria (HP:0002913)4.04288063
43Ketosis (HP:0001946)4.03710793
44Fat malabsorption (HP:0002630)3.96337982
45Supraventricular tachycardia (HP:0004755)3.95676028
46Neck muscle weakness (HP:0000467)3.94060702
47Distal lower limb muscle weakness (HP:0009053)3.89633889
48* Abnormality of the intrinsic pathway (HP:0010989)3.88500639
49Supraventricular arrhythmia (HP:0005115)3.85406265
50Abnormality of glutamine family amino acid metabolism (HP:0010902)3.84350653
51Dilated cardiomyopathy (HP:0001644)3.83887992
52Abnormality of sulfur amino acid metabolism (HP:0004339)3.82361177
53Abnormality of methionine metabolism (HP:0010901)3.79432639
54Ventricular arrhythmia (HP:0004308)3.78454204
55Atrioventricular block (HP:0001678)3.73190347
56Increased connective tissue (HP:0009025)3.72739899
57Rimmed vacuoles (HP:0003805)3.70453015
58Rhabdomyolysis (HP:0003201)3.69925728
59Hyperglycinuria (HP:0003108)3.68939626
60Abnormality of aspartate family amino acid metabolism (HP:0010899)3.67285790
61Subaortic stenosis (HP:0001682)3.65805974
62Abnormality of the left ventricular outflow tract (HP:0011103)3.65805974
63Abnormality of skeletal muscle fiber size (HP:0012084)3.61338383
64Conjugated hyperbilirubinemia (HP:0002908)3.61109146
65Abnormality of glycine metabolism (HP:0010895)3.60945932
66Abnormality of serine family amino acid metabolism (HP:0010894)3.60945932
67Difficulty running (HP:0009046)3.60754306
68Increased variability in muscle fiber diameter (HP:0003557)3.60426610
69Abnormality of complement system (HP:0005339)3.57617149
70Ventricular fibrillation (HP:0001663)3.51130550
71Hypercholesterolemia (HP:0003124)3.46815219
72Hypoglycemic seizures (HP:0002173)3.34217062
73Centrally nucleated skeletal muscle fibers (HP:0003687)3.32028058
74Nonimmune hydrops fetalis (HP:0001790)3.31797586
75Abnormality of pyrimidine metabolism (HP:0004353)3.29125429
76Ketoacidosis (HP:0001993)3.22186930
77Myocardial infarction (HP:0001658)3.16387955
78Hyperbilirubinemia (HP:0002904)3.14426675
79Abnormality of nucleobase metabolism (HP:0010932)3.10762942
80Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.09892991
81Abnormality of fatty-acid metabolism (HP:0004359)3.08330429
82Abnormality of purine metabolism (HP:0004352)3.01581698
83Delayed CNS myelination (HP:0002188)3.00630511
84Hepatocellular carcinoma (HP:0001402)2.99875982
85Areflexia of lower limbs (HP:0002522)2.96176678
86Frequent falls (HP:0002359)2.88255066
87EMG: neuropathic changes (HP:0003445)2.87566177
88Steatorrhea (HP:0002570)2.80602797
89Vascular calcification (HP:0004934)2.80543230
90Abnormality of the foot musculature (HP:0001436)2.75876898
91Abnormality of serum amino acid levels (HP:0003112)2.75564586
92Hypochromic microcytic anemia (HP:0004840)2.75473380
93Skin nodule (HP:0200036)2.72942429
94Esophageal varix (HP:0002040)2.68266327
95Palpitations (HP:0001962)2.64453846
96Systemic lupus erythematosus (HP:0002725)2.63605788
97Prolonged QT interval (HP:0001657)2.63600496
98Acanthocytosis (HP:0001927)2.60172790
99Foot dorsiflexor weakness (HP:0009027)2.59245685
100Hyperinsulinemic hypoglycemia (HP:0000825)2.59151956
101Glomerulonephritis (HP:0000099)2.56631615
102Dicarboxylic aciduria (HP:0003215)2.55025736
103Abnormality of dicarboxylic acid metabolism (HP:0010995)2.55025736
104Cardiovascular calcification (HP:0011915)2.53039267
105Generalized muscle weakness (HP:0003324)2.50841487
106Ragged-red muscle fibers (HP:0003200)2.49273960
107Bulbar palsy (HP:0001283)2.48171694
108Generalized aminoaciduria (HP:0002909)2.44719047
109Metabolic acidosis (HP:0001942)2.42693833
110Spontaneous abortion (HP:0005268)2.42031767
111Abnormal EKG (HP:0003115)2.40428830
112Mitral stenosis (HP:0001718)2.36396719
113Lethargy (HP:0001254)2.36001145
114Hemorrhage of the eye (HP:0011885)2.35876096
115Scapular winging (HP:0003691)2.33580789
116Symptomatic seizures (HP:0011145)2.32642415
117Myotonia (HP:0002486)2.30710486
118Distal arthrogryposis (HP:0005684)2.29962383
119Round ear (HP:0100830)2.29597375
120Amyloidosis (HP:0011034)2.28572665
121Distal lower limb amyotrophy (HP:0008944)2.26610941
122Abnormal gallbladder morphology (HP:0012437)2.25420927
123Left ventricular hypertrophy (HP:0001712)2.25131748
124Recurrent gram-negative bacterial infections (HP:0005420)2.22320378
125Thrombophlebitis (HP:0004418)2.22252097
126Hyperglycemia (HP:0003074)2.21418030
127Oligomenorrhea (HP:0000876)2.21243409
128Enlarged kidneys (HP:0000105)2.20275311
129Gowers sign (HP:0003391)2.20080151
130Gout (HP:0001997)2.18439070
131Pancreatitis (HP:0001733)2.16656143
132Gingival bleeding (HP:0000225)2.16486353
133Mildly elevated creatine phosphokinase (HP:0008180)2.14571665
134Sensorimotor neuropathy (HP:0007141)2.13254071
135Sudden cardiac death (HP:0001645)2.12563763
136Cholecystitis (HP:0001082)2.11208637
137Abnormal gallbladder physiology (HP:0012438)2.11208637
138Myopathic facies (HP:0002058)2.10075913
139Renal cortical cysts (HP:0000803)2.08168953
140Irritability (HP:0000737)2.05945647
141Cholelithiasis (HP:0001081)2.05244549
142Cerebral edema (HP:0002181)2.05113631
143Late onset (HP:0003584)2.04299696
144Polycythemia (HP:0001901)2.04019478
145Difficulty climbing stairs (HP:0003551)2.03392238
146Steppage gait (HP:0003376)2.02201553
147Cerebral hemorrhage (HP:0001342)2.00554279
148Abnormal enzyme/coenzyme activity (HP:0012379)2.00219206
149Spastic diplegia (HP:0001264)1.97467936
150Muscular dystrophy (HP:0003560)1.96033404
151Menorrhagia (HP:0000132)1.94960300
152Neonatal onset (HP:0003623)1.94320864
153Elevated hepatic transaminases (HP:0002910)1.92476539
154Limb-girdle muscle atrophy (HP:0003797)1.92076822
155Elevated alkaline phosphatase (HP:0003155)1.91985925
156Rickets (HP:0002748)1.91471689
157Nephritis (HP:0000123)1.89890714
158Dysmetric saccades (HP:0000641)1.88688589
159Alkalosis (HP:0001948)1.87780199
160Poikilocytosis (HP:0004447)1.87156233
161Muscle stiffness (HP:0003552)1.87089830
162Proximal tubulopathy (HP:0000114)1.84455999
163Spinal rigidity (HP:0003306)1.83669182
164Abnormality of the gallbladder (HP:0005264)1.83091720
165Hydroxyprolinuria (HP:0003080)1.82011999
166Abnormality of proline metabolism (HP:0010907)1.82011999
167Pulmonary embolism (HP:0002204)1.81446775
168Opisthotonus (HP:0002179)1.80371158
169Vomiting (HP:0002013)1.80359485
170Spontaneous hematomas (HP:0007420)1.80152628
171Proximal amyotrophy (HP:0007126)1.76155874
172Weak cry (HP:0001612)1.70593859
173Abnormality of the shoulder girdle musculature (HP:0001435)1.68441838
174Ulnar deviation of the wrist (HP:0003049)1.67761027
175Toxemia of pregnancy (HP:0100603)1.67080179
176Increased serum pyruvate (HP:0003542)1.66139928
177Respiratory insufficiency due to muscle weakness (HP:0002747)1.65669025
178Palmoplantar keratoderma (HP:0000982)1.64915518
179Aortic aneurysm (HP:0004942)1.59715019
180Facial diplegia (HP:0001349)1.59671762
181Pheochromocytoma (HP:0002666)1.59100636
182Malignant hyperthermia (HP:0002047)1.56354847
183Lower limb amyotrophy (HP:0007210)1.55771728
184Insulin-resistant diabetes mellitus (HP:0000831)1.55481677
185Congestive heart failure (HP:0001635)1.55395848
186Slender build (HP:0001533)1.44254345
187Bradycardia (HP:0001662)1.43168103
188Neuroendocrine neoplasm (HP:0100634)1.42412578
189Osteolytic defects of the hand bones (HP:0009699)1.41136485
190Osteolytic defects of the phalanges of the hand (HP:0009771)1.41136485

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KDR7.38118484
2OBSCN6.88326690
3TTN5.15006401
4TIE14.77231598
5MYLK4.56790909
6BCKDK3.45533390
7INSRR3.39908965
8ERN13.22255536
9SIK13.05163802
10PHKG13.04888464
11PHKG23.04888464
12FGFR42.90427527
13DMPK2.63593298
14PTK62.49746270
15STK162.36334252
16MAP3K62.17889106
17TGFBR22.14523674
18MAP3K142.09086381
19TAOK32.05910838
20JAK11.97751479
21DAPK21.68950686
22FRK1.68454119
23TRPM71.67142669
24MUSK1.65691773
25TAOK11.60434171
26MARK11.57703147
27FLT31.57004249
28ERBB41.53139270
29TYK21.47343169
30PIK3CG1.46982760
31LATS11.45884942
32JAK21.38173114
33JAK31.37289324
34IRAK31.31290782
35MAP3K51.28677086
36TGFBR11.28076795
37RIPK11.26000530
38MAPKAPK31.25765678
39MAPK151.24783493
40MAP3K31.20925072
41TRIB31.18618324
42PKN21.18334359
43PRKD11.17759698
44ROCK11.16453791
45MAPK111.15930083
46PDK21.15241881
47EPHB11.11815135
48PAK31.11085276
49NEK91.10646639
50VRK11.08458320
51CAMK2D1.07813626
52GRK10.96177920
53CAMK10.94396130
54CDC42BPA0.92550960
55EPHB20.92009006
56EPHA30.90219813
57MST1R0.89811099
58PIK3CA0.87163365
59FGFR20.85441859
60STK380.85083050
61NEK10.84179360
62GSK3A0.81542792
63AKT30.81158708
64BLK0.78987543
65GRK70.78929992
66DYRK1B0.78737569
67PRKAA20.77758350
68FGFR30.77755341
69MAP3K130.77459692
70ABL20.77315942
71CAMK1D0.76798715
72PTK2B0.75285002
73PKN10.74215774
74PNCK0.72815917
75MST40.71460675
76CAMK2G0.71403746
77MAP2K40.71208457
78SGK20.70213430
79CAMK2A0.69929804
80CDK60.69285323
81ROCK20.68408143
82BMPR1B0.68157494
83LIMK10.67310554
84SGK30.67135724
85CSNK1G10.66535775
86CAMK2B0.65488154
87TBK10.65359471
88MAP3K70.64774534
89MET0.64719455
90PRKG10.64715329
91PRPF4B0.63803420
92DDR20.63790524
93MAPK70.61884467
94MAPK130.61688061
95LATS20.60454222
96MAP2K30.60076348
97NLK0.59536045
98CAMK40.56761987
99SGK2230.55569813
100SGK4940.55569813
101DAPK30.54724028
102MAPK120.54627640
103KSR20.54047455
104IGF1R0.52609844
105PDPK10.50126608
106ERBB20.48979680
107WNK40.47955214
108MAPK40.47855648
109STK38L0.47582286
110AKT20.47237988
111ZAP700.46742014
112CSK0.46406689
113PRKACG0.46283543
114STK30.46229756
115BMX0.45415832
116CDK90.44940497
117CHUK0.43826120
118PRKAA10.43404638
119PRKACB0.43165931
120TAOK20.42182257
121UHMK10.41490320
122MAP3K40.41481540
123MAP2K10.40828627
124PRKCE0.40756224
125PRKACA0.40529466
126RPS6KA30.40485752
127MOS0.40441447
128GRK50.40055907
129PRKCZ0.39435886
130PDGFRA0.38348620
131PRKCH0.37997963
132EPHA20.36850763
133LMTK20.35337669
134EGFR0.34869945
135PDK10.34341795
136CDK50.31872231
137ZAK0.30967108
138PRKCQ0.30260877
139SGK10.28199391
140PTK20.28108249
141MAPK100.27732941
142CCNB10.27395422
143IKBKE0.27043368
144CSNK1A1L0.26766604
145NUAK10.26325252
146MAP3K20.25549812
147RPS6KC10.24128184
148MAP2K20.22055581
149PINK10.22047598
150ABL10.21265970
151IRAK40.21251045
152CAMK1G0.21243182
153RET0.21177766
154PRKCD0.19406529
155PDGFRB0.19332008
156INSR0.19325538
157MAPK30.19310705
158LYN0.18853964
159FER0.18074986

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.42056826
2Dilated cardiomyopathy_Homo sapiens_hsa054143.84139011
3Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.76875632
4Nitrogen metabolism_Homo sapiens_hsa009103.49957961
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.31493291
6* Complement and coagulation cascades_Homo sapiens_hsa046103.03963954
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.83200467
8Fatty acid degradation_Homo sapiens_hsa000712.80229760
9Arginine biosynthesis_Homo sapiens_hsa002202.79182379
10Tryptophan metabolism_Homo sapiens_hsa003802.78993557
11Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.65331855
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.43383767
13Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.40233077
14Cardiac muscle contraction_Homo sapiens_hsa042602.38506490
15Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.32893491
16Histidine metabolism_Homo sapiens_hsa003402.31760771
17Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.26563663
18Pentose and glucuronate interconversions_Homo sapiens_hsa000402.25930458
19PPAR signaling pathway_Homo sapiens_hsa033202.07658666
20Butanoate metabolism_Homo sapiens_hsa006502.06256545
21Fatty acid metabolism_Homo sapiens_hsa012122.05881419
22Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.02451584
23Peroxisome_Homo sapiens_hsa041462.01986805
24Propanoate metabolism_Homo sapiens_hsa006402.01683284
25Staphylococcus aureus infection_Homo sapiens_hsa051501.99139769
26Circadian rhythm_Homo sapiens_hsa047101.92820384
27Steroid hormone biosynthesis_Homo sapiens_hsa001401.90283132
28Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.88165719
29Maturity onset diabetes of the young_Homo sapiens_hsa049501.86207865
30Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.78906245
31Chemical carcinogenesis_Homo sapiens_hsa052041.78832250
32Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.75327819
33beta-Alanine metabolism_Homo sapiens_hsa004101.74328568
34Drug metabolism - other enzymes_Homo sapiens_hsa009831.71324047
35Sulfur metabolism_Homo sapiens_hsa009201.71256392
36Retinol metabolism_Homo sapiens_hsa008301.58466035
37Caffeine metabolism_Homo sapiens_hsa002321.57292422
38Bile secretion_Homo sapiens_hsa049761.54150299
39ABC transporters_Homo sapiens_hsa020101.53197760
40Phenylalanine metabolism_Homo sapiens_hsa003601.51678803
41Selenocompound metabolism_Homo sapiens_hsa004501.44437876
42Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.42951192
43Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.39806680
44Starch and sucrose metabolism_Homo sapiens_hsa005001.38700879
45Vascular smooth muscle contraction_Homo sapiens_hsa042701.38530122
46Tyrosine metabolism_Homo sapiens_hsa003501.35930129
47Fatty acid elongation_Homo sapiens_hsa000621.34730695
48cGMP-PKG signaling pathway_Homo sapiens_hsa040221.33526895
49Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.30165679
50Renin secretion_Homo sapiens_hsa049241.27512721
51Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.27079748
52Pyruvate metabolism_Homo sapiens_hsa006201.26998144
53Folate biosynthesis_Homo sapiens_hsa007901.19862314
54Vitamin digestion and absorption_Homo sapiens_hsa049771.05511262
55Focal adhesion_Homo sapiens_hsa045101.03949401
562-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.02416200
57Steroid biosynthesis_Homo sapiens_hsa001001.02057449
58Calcium signaling pathway_Homo sapiens_hsa040201.01404190
59Oxytocin signaling pathway_Homo sapiens_hsa049211.00891827
60Fat digestion and absorption_Homo sapiens_hsa049750.99630589
61Cysteine and methionine metabolism_Homo sapiens_hsa002700.98805432
62Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.98486077
63Sulfur relay system_Homo sapiens_hsa041220.96179166
64Aldosterone synthesis and secretion_Homo sapiens_hsa049250.95118142
65Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.94998534
66ECM-receptor interaction_Homo sapiens_hsa045120.91383333
67Platelet activation_Homo sapiens_hsa046110.91181216
68Carbon metabolism_Homo sapiens_hsa012000.88191635
69Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.88118082
70Lysine degradation_Homo sapiens_hsa003100.86193188
71Arginine and proline metabolism_Homo sapiens_hsa003300.85927177
72Biosynthesis of amino acids_Homo sapiens_hsa012300.82555833
73Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.79945029
74Vitamin B6 metabolism_Homo sapiens_hsa007500.74709159
75Circadian entrainment_Homo sapiens_hsa047130.74492064
76Gastric acid secretion_Homo sapiens_hsa049710.73095359
77cAMP signaling pathway_Homo sapiens_hsa040240.67586645
78Fatty acid biosynthesis_Homo sapiens_hsa000610.65605682
79Viral myocarditis_Homo sapiens_hsa054160.64520410
80Glycerolipid metabolism_Homo sapiens_hsa005610.61631026
81Cyanoamino acid metabolism_Homo sapiens_hsa004600.61354955
82Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.56724478
83Adipocytokine signaling pathway_Homo sapiens_hsa049200.56697453
84Long-term potentiation_Homo sapiens_hsa047200.56502829
85Pancreatic secretion_Homo sapiens_hsa049720.55154948
86Gap junction_Homo sapiens_hsa045400.52523323
87Insulin resistance_Homo sapiens_hsa049310.51251117
88Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.49806712
89GnRH signaling pathway_Homo sapiens_hsa049120.49687617
90Insulin secretion_Homo sapiens_hsa049110.49593783
91One carbon pool by folate_Homo sapiens_hsa006700.48403047
92Salivary secretion_Homo sapiens_hsa049700.45640995
93Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.44968212
94Regulation of actin cytoskeleton_Homo sapiens_hsa048100.44532328
95Longevity regulating pathway - mammal_Homo sapiens_hsa042110.44389095
96Glutathione metabolism_Homo sapiens_hsa004800.43931637
97Adherens junction_Homo sapiens_hsa045200.42828536
98Thyroid hormone signaling pathway_Homo sapiens_hsa049190.42168760
99Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.40228672
100Prion diseases_Homo sapiens_hsa050200.39634545
101Arachidonic acid metabolism_Homo sapiens_hsa005900.38654566
102Metabolic pathways_Homo sapiens_hsa011000.38318019
103African trypanosomiasis_Homo sapiens_hsa051430.35292878
104Malaria_Homo sapiens_hsa051440.34160157
105Phospholipase D signaling pathway_Homo sapiens_hsa040720.33861868
106Amphetamine addiction_Homo sapiens_hsa050310.32285120
107Glucagon signaling pathway_Homo sapiens_hsa049220.31879156
108Morphine addiction_Homo sapiens_hsa050320.31254036
109Pentose phosphate pathway_Homo sapiens_hsa000300.30642980
110GABAergic synapse_Homo sapiens_hsa047270.28868371
111Tight junction_Homo sapiens_hsa045300.28225544
112Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.24678153
113Glycosaminoglycan degradation_Homo sapiens_hsa005310.23220598
114Leukocyte transendothelial migration_Homo sapiens_hsa046700.20930346
115alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.20534207
116Galactose metabolism_Homo sapiens_hsa000520.19390772
117Fructose and mannose metabolism_Homo sapiens_hsa000510.12822142
118Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.11087523
119AMPK signaling pathway_Homo sapiens_hsa041520.10660072
120Ovarian steroidogenesis_Homo sapiens_hsa049130.10128195
121Linoleic acid metabolism_Homo sapiens_hsa005910.07453686
122Hepatitis C_Homo sapiens_hsa051600.01501999
123FoxO signaling pathway_Homo sapiens_hsa04068-0.1324913
124Pertussis_Homo sapiens_hsa05133-0.1218091
125Amoebiasis_Homo sapiens_hsa05146-0.1186161
126Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.1170399
127RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622-0.1161140
128Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060-0.1124402
129Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.1019987
130NF-kappa B signaling pathway_Homo sapiens_hsa04064-0.1001690
131Regulation of autophagy_Homo sapiens_hsa04140-0.0952146
132Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.0888396
133Type II diabetes mellitus_Homo sapiens_hsa04930-0.0851364
134Terpenoid backbone biosynthesis_Homo sapiens_hsa00900-0.0814554
135Thyroid hormone synthesis_Homo sapiens_hsa04918-0.0764642
136Lysosome_Homo sapiens_hsa04142-0.0660304
137Insulin signaling pathway_Homo sapiens_hsa04910-0.0370309
138Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.0240664
139Glycerophospholipid metabolism_Homo sapiens_hsa00564-0.0233429

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