F8A2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is part of a region that is repeated three times on chromosome X, once in intron 22 of the F8 gene and twice closer to the Xq telomere. This record represents the middle copy. Although its function is unknown, the observation that this gene is conserved in the mouse implies it has some function. Unlike factor VIII, this gene is transcribed abundantly in a wide variety of cell types. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chromatin assembly (GO:0031497)6.63600423
2innate immune response in mucosa (GO:0002227)6.38700330
3negative regulation of B cell apoptotic process (GO:0002903)5.42206094
4mucosal immune response (GO:0002385)5.28469978
5T-helper 1 type immune response (GO:0042088)5.27871456
6viral mRNA export from host cell nucleus (GO:0046784)5.23465276
7deoxyribonucleoside monophosphate metabolic process (GO:0009162)5.20218885
8positive regulation of interferon-gamma biosynthetic process (GO:0045078)5.11458134
9antibacterial humoral response (GO:0019731)5.06575757
10organ or tissue specific immune response (GO:0002251)4.72513262
11nucleosome assembly (GO:0006334)4.62750545
12antimicrobial humoral response (GO:0019730)4.59789406
13DNA replication-dependent nucleosome organization (GO:0034723)4.52806820
14DNA replication-dependent nucleosome assembly (GO:0006335)4.52806820
15positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610814.31458217
16immunoglobulin mediated immune response (GO:0016064)4.30654440
17negative regulation of myeloid cell apoptotic process (GO:0033033)4.14691395
18tongue development (GO:0043586)4.12765976
19protein-DNA complex assembly (GO:0065004)4.10561934
20regulation of B cell apoptotic process (GO:0002902)4.05048070
21lymph vessel development (GO:0001945)4.03241700
22regulation of apoptotic process involved in morphogenesis (GO:1902337)4.02429192
23pseudouridine synthesis (GO:0001522)3.93531855
24regulation of interferon-gamma biosynthetic process (GO:0045072)3.92281138
25negative regulation of telomerase activity (GO:0051974)3.87432496
26peptidyl-arginine omega-N-methylation (GO:0035247)3.87156252
27pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.83862625
28nucleosome organization (GO:0034728)3.81528020
29positive regulation of prostaglandin secretion (GO:0032308)3.78335091
30chaperone mediated protein folding requiring cofactor (GO:0051085)3.72718859
31proline biosynthetic process (GO:0006561)3.71124410
32DNA deamination (GO:0045006)3.69479245
33ribosomal small subunit biogenesis (GO:0042274)3.63049748
34regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.50814941
35GTP biosynthetic process (GO:0006183)3.48821540
36protein-DNA complex subunit organization (GO:0071824)3.48278034
37negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.48101376
38UTP biosynthetic process (GO:0006228)3.42729251
39diaphragm development (GO:0060539)3.41243323
40chromatin assembly or disassembly (GO:0006333)3.37439597
41negative regulation of B cell proliferation (GO:0030889)3.34413703
42positive regulation of histone deacetylation (GO:0031065)3.34413053
43B cell mediated immunity (GO:0019724)3.28926839
44positive regulation of macrophage cytokine production (GO:0060907)3.23467117
45negative regulation of phagocytosis (GO:0050765)3.22398125
46base-excision repair, AP site formation (GO:0006285)3.18577804
47pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.17110714
48skeletal muscle organ development (GO:0060538)3.13902655
49pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.11998191
50negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.09843749
51heterochromatin organization (GO:0070828)3.09730282
52prostaglandin biosynthetic process (GO:0001516)3.08436660
53prostanoid biosynthetic process (GO:0046457)3.08436660
54pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.04871050
55regulation of prostaglandin secretion (GO:0032306)3.03098323
56regulation of mammary gland epithelial cell proliferation (GO:0033599)3.02215829
57peptidyl-arginine N-methylation (GO:0035246)3.01712724
58peptidyl-arginine methylation (GO:0018216)3.01712724
59negative regulation of cell aging (GO:0090344)2.96827141
60UTP metabolic process (GO:0046051)2.93324995
61negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)2.93205435
62regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 2.92483146
63positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.91194710
64histone arginine methylation (GO:0034969)2.91097646
65regulation of mitochondrial translation (GO:0070129)2.90414553
66positive regulation of T cell mediated cytotoxicity (GO:0001916)2.90156649
67mitochondrial respiratory chain complex I assembly (GO:0032981)2.89279547
68NADH dehydrogenase complex assembly (GO:0010257)2.89279547
69mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.89279547
70regulation of odontogenesis of dentin-containing tooth (GO:0042487)2.89078849
71negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 2.86428254
72B cell receptor signaling pathway (GO:0050853)2.85704805
73pyrimidine nucleotide catabolic process (GO:0006244)2.85377711
74regulation of nuclear cell cycle DNA replication (GO:0033262)2.83730922
75tRNA modification (GO:0006400)2.82188471
76positive regulation of humoral immune response (GO:0002922)2.79323749
77regulation of B cell proliferation (GO:0030888)2.78721261
78deoxyribonucleotide catabolic process (GO:0009264)2.77567775
79regulation of chromatin binding (GO:0035561)2.76198782
80cellular response to interferon-beta (GO:0035458)2.75559951
81regulation of protein heterodimerization activity (GO:0043497)2.74303896
82DNA damage response, detection of DNA damage (GO:0042769)2.71595098
83B cell proliferation (GO:0042100)2.71218957
84B cell homeostasis (GO:0001782)2.70861461
85protein neddylation (GO:0045116)2.70522508
86positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)2.70478339
87viral transcription (GO:0019083)2.69696426
88positive regulation of protein kinase C signaling (GO:0090037)2.69167243
89positive regulation of muscle cell apoptotic process (GO:0010661)2.69146741
90transcription from mitochondrial promoter (GO:0006390)2.68357611
91guanosine-containing compound biosynthetic process (GO:1901070)2.64619205
92regulation of telomerase activity (GO:0051972)2.63972719
93pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.63075327
94CTP biosynthetic process (GO:0006241)2.62690241
95CTP metabolic process (GO:0046036)2.62690241
96regulation of cell aging (GO:0090342)2.58789741
97antigen processing and presentation of endogenous antigen (GO:0019883)2.58465512
98energy coupled proton transport, down electrochemical gradient (GO:0015985)2.58155402
99ATP synthesis coupled proton transport (GO:0015986)2.58155402
100deoxyribose phosphate catabolic process (GO:0046386)2.56596708

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse3.39163978
2MYC_22102868_ChIP-Seq_BL_Human2.81221187
3VDR_21846776_ChIP-Seq_THP-1_Human2.69797107
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.56873735
5E2F7_22180533_ChIP-Seq_HELA_Human2.55086838
6E2F4_17652178_ChIP-ChIP_JURKAT_Human2.47945801
7SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.35966933
8HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.34427511
9EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.28931134
10SOX2_16153702_ChIP-ChIP_HESCs_Human2.18171192
11RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.17106955
12SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.10431886
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.03171015
14FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse10.0757498
15CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.98594112
16MYC_18555785_ChIP-Seq_MESCs_Mouse1.96632205
17E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.91631086
18LXR_22292898_ChIP-Seq_THP-1_Human1.86560482
19KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.84078774
20CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.83775174
21CIITA_25753668_ChIP-Seq_RAJI_Human1.79375515
22ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.78942649
23EGR1_23403033_ChIP-Seq_LIVER_Mouse1.78708478
24POU5F1_16153702_ChIP-ChIP_HESCs_Human1.78005835
25MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.75816985
26MYC_18358816_ChIP-ChIP_MESCs_Mouse1.72109049
27THAP11_20581084_ChIP-Seq_MESCs_Mouse1.71539194
28NOTCH1_21737748_ChIP-Seq_TLL_Human1.71022622
29ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.64043048
30FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.60706464
31HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.57506171
32XRN2_22483619_ChIP-Seq_HELA_Human1.56002625
33JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.54327889
34MAF_26560356_Chip-Seq_TH1_Human1.52969926
35PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.51603549
36CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.50400965
37MYC_19030024_ChIP-ChIP_MESCs_Mouse1.49288438
38NELFA_20434984_ChIP-Seq_ESCs_Mouse1.48499117
39IRF1_19129219_ChIP-ChIP_H3396_Human1.46616084
40NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.45046112
41P68_20966046_ChIP-Seq_HELA_Human1.44461238
42TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.43621110
43E2F1_21310950_ChIP-Seq_MCF-7_Human1.41880222
44ETS1_20019798_ChIP-Seq_JURKAT_Human1.41393464
45YY1_21170310_ChIP-Seq_MESCs_Mouse1.41020774
46IRF8_22096565_ChIP-ChIP_GC-B_Human1.39697307
47CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.39428475
48MYC_18940864_ChIP-ChIP_HL60_Human1.38430914
49KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.37501361
50DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.37322865
51MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.35793505
52CBX2_27304074_Chip-Seq_ESCs_Mouse1.33327286
53KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.32323462
54CREB1_15753290_ChIP-ChIP_HEK293T_Human1.28015350
55BCL6_27268052_Chip-Seq_Bcells_Human1.25491308
56VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.24577146
57STAT4_19710469_ChIP-ChIP_TH1__Mouse1.23466073
58E2F1_18555785_ChIP-Seq_MESCs_Mouse1.22798247
59DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.22387228
60E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.22085783
61ELF1_20517297_ChIP-Seq_JURKAT_Human1.21195461
62MAF_26560356_Chip-Seq_TH2_Human1.19771016
63POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.19386488
64SA1_27219007_Chip-Seq_ERYTHROID_Human1.18582189
65SRY_22984422_ChIP-ChIP_TESTIS_Rat1.17982035
66HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.17933654
67ERG_20887958_ChIP-Seq_HPC-7_Mouse1.17909412
68VDR_24763502_ChIP-Seq_THP-1_Human1.17783927
69EED_16625203_ChIP-ChIP_MESCs_Mouse1.17422364
70IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.17303397
71TP63_17297297_ChIP-ChIP_HaCaT_Human1.17044156
72FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.16864217
73VDR_23849224_ChIP-Seq_CD4+_Human1.13638237
74BCOR_27268052_Chip-Seq_Bcells_Human1.13143751
75KDM2B_26808549_Chip-Seq_SUP-B15_Human1.11155468
76IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.09679347
77TP53_20018659_ChIP-ChIP_R1E_Mouse1.08916881
78E2F1_20622854_ChIP-Seq_HELA_Human1.07652962
79BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.07323375
80ELF1_17652178_ChIP-ChIP_JURKAT_Human1.05909769
81KDM2B_26808549_Chip-Seq_DND41_Human1.05054341
82UTX_26944678_Chip-Seq_JUKART_Human1.04796459
83SOX2_18555785_ChIP-Seq_MESCs_Mouse1.04513580
84ELK3_25401928_ChIP-Seq_HUVEC_Human1.04011634
85PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.03136369
86PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.01118235
87DCP1A_22483619_ChIP-Seq_HELA_Human1.01034581
88NANOG_16153702_ChIP-ChIP_HESCs_Human1.00415734
89NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.00302015
90TET1_21451524_ChIP-Seq_MESCs_Mouse0.99778198
91SOX2_18692474_ChIP-Seq_MESCs_Mouse0.99308005
92FOXM1_23109430_ChIP-Seq_U2OS_Human0.99266092
93ZNF263_19887448_ChIP-Seq_K562_Human0.98563808
94SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.98269518
95TTF2_22483619_ChIP-Seq_HELA_Human0.98181193
96PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.97614232
97NANOG_18555785_ChIP-Seq_MESCs_Mouse0.96771066
98KDM2B_26808549_Chip-Seq_JURKAT_Human0.95251716
99HOXB4_20404135_ChIP-ChIP_EML_Mouse0.95150806
100KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.93383492

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005645_abnormal_hypothalamus_physiol7.99936649
2MP0005623_abnormal_meninges_morphology4.73676479
3MP0000685_abnormal_immune_system3.75263207
4MP0002163_abnormal_gland_morphology3.29236950
5MP0001346_abnormal_lacrimal_gland3.15098861
6MP0002249_abnormal_larynx_morphology3.04032315
7MP0001986_abnormal_taste_sensitivity3.00502363
8MP0005671_abnormal_response_to2.90808295
9MP0009046_muscle_twitch2.45245669
10MP0002653_abnormal_ependyma_morphology2.00603799
11MP0001790_abnormal_immune_system1.92354961
12MP0005387_immune_system_phenotype1.92354961
13MP0002234_abnormal_pharynx_morphology1.86610396
14MP0010094_abnormal_chromosome_stability1.86556497
15MP0000631_abnormal_neuroendocrine_gland1.85022477
16MP0003111_abnormal_nucleus_morphology1.84191548
17MP0003283_abnormal_digestive_organ1.79111196
18MP0001800_abnormal_humoral_immune1.78940639
19MP0001919_abnormal_reproductive_system1.76178253
20MP0000049_abnormal_middle_ear1.72340890
21MP0005367_renal/urinary_system_phenotyp1.71987622
22MP0000516_abnormal_urinary_system1.71987622
23MP0003693_abnormal_embryo_hatching1.69424654
24MP0009053_abnormal_anal_canal1.58248131
25MP0003315_abnormal_perineum_morphology1.53168918
26MP0002160_abnormal_reproductive_system1.51291643
27MP0006292_abnormal_olfactory_placode1.43882171
28MP0001727_abnormal_embryo_implantation1.43529357
29MP0005084_abnormal_gallbladder_morpholo1.43526006
30MP0005646_abnormal_pituitary_gland1.43026625
31MP0005000_abnormal_immune_tolerance1.36924720
32MP0003077_abnormal_cell_cycle1.35560220
33MP0005670_abnormal_white_adipose1.34895021
34MP0001529_abnormal_vocalization1.34831577
35MP0009250_abnormal_appendicular_skeleto1.32827858
36MP0001835_abnormal_antigen_presentation1.31924334
37MP0002282_abnormal_trachea_morphology1.31232973
38MP0005389_reproductive_system_phenotype1.28339923
39MP0004858_abnormal_nervous_system1.26139212
40MP0002398_abnormal_bone_marrow1.23744931
41MP0003763_abnormal_thymus_physiology1.23111165
42MP0009333_abnormal_splenocyte_physiolog1.21697543
43MP0002735_abnormal_chemical_nociception1.20474410
44MP0002723_abnormal_immune_serum1.19174558
45MP0000026_abnormal_inner_ear1.17189128
46MP0000566_synostosis1.16247199
47MP0005379_endocrine/exocrine_gland_phen1.13970396
48MP0002277_abnormal_respiratory_mucosa1.10702683
49MP0000678_abnormal_parathyroid_gland1.08520299
50MP0010234_abnormal_vibrissa_follicle1.08216310
51MP0008058_abnormal_DNA_repair1.04359034
52MP0002452_abnormal_antigen_presenting1.04200285
53MP0003942_abnormal_urinary_system1.01986602
54MP0000716_abnormal_immune_system1.00314476
55MP0000537_abnormal_urethra_morphology1.00273601
56MP0002722_abnormal_immune_system0.99862066
57MP0001881_abnormal_mammary_gland0.99452302
58MP0000681_abnormal_thyroid_gland0.98780919
59MP0002420_abnormal_adaptive_immunity0.98533772
60MP0002693_abnormal_pancreas_physiology0.96399229
61MP0002429_abnormal_blood_cell0.95100001
62MP0001819_abnormal_immune_cell0.93700575
63MP0000689_abnormal_spleen_morphology0.93081155
64MP0005310_abnormal_salivary_gland0.92277028
65MP0001188_hyperpigmentation0.89265044
66MP0001664_abnormal_digestion0.87953044
67MP0005187_abnormal_penis_morphology0.83072907
68MP0000350_abnormal_cell_proliferation0.82674958
69MP0005025_abnormal_response_to0.81166863
70MP0008932_abnormal_embryonic_tissue0.79522431
71MP0000703_abnormal_thymus_morphology0.78644079
72MP0000534_abnormal_ureter_morphology0.78462983
73MP0000313_abnormal_cell_death0.78223828
74MP0003183_abnormal_peptide_metabolism0.78044913
75MP0004133_heterotaxia0.74319796
76MP0002822_catalepsy0.73999262
77MP0003119_abnormal_digestive_system0.72787395
78MP0000733_abnormal_muscle_development0.71146588
79MP0002111_abnormal_tail_morphology0.70798358
80MP0002210_abnormal_sex_determination0.70791742
81MP0001270_distended_abdomen0.70443159
82MP0002733_abnormal_thermal_nociception0.69015080
83MP0000490_abnormal_crypts_of0.67200280
84MP0000465_gastrointestinal_hemorrhage0.62729386
85MP0002138_abnormal_hepatobiliary_system0.60969280
86MP0002019_abnormal_tumor_incidence0.60112048
87MP0002752_abnormal_somatic_nervous0.59730435
88MP0001968_abnormal_touch/_nociception0.59209843
89MP0005076_abnormal_cell_differentiation0.58785026
90MP0008872_abnormal_physiological_respon0.57725186
91MP0002177_abnormal_outer_ear0.57456060
92MP0003861_abnormal_nervous_system0.57374117
93MP0009379_abnormal_foot_pigmentation0.57282514
94MP0004142_abnormal_muscle_tone0.54273358
95MP0000955_abnormal_spinal_cord0.54202476
96MP0003938_abnormal_ear_development0.53928422
97MP0006035_abnormal_mitochondrial_morpho0.53784212
98MP0001944_abnormal_pancreas_morphology0.53369032
99MP0010030_abnormal_orbit_morphology0.51401335
100MP0002166_altered_tumor_susceptibility0.51230332

Predicted human phenotypes

RankGene SetZ-score
1Gastrointestinal stroma tumor (HP:0100723)7.05235723
2Recurrent sinusitis (HP:0011108)5.21579039
3Agammaglobulinemia (HP:0004432)4.92471876
4IgA deficiency (HP:0002720)4.25064142
5IgM deficiency (HP:0002850)4.20222143
6Abnormal number of erythroid precursors (HP:0012131)3.85703213
7Aplasia/Hypoplasia of the sacrum (HP:0008517)3.85598274
8Recurrent bronchitis (HP:0002837)3.82570910
9Dry hair (HP:0011359)3.78971625
10Meningitis (HP:0001287)3.64392526
11Emphysema (HP:0002097)3.53864013
12Squamous cell carcinoma (HP:0002860)3.47462244
13Abnormality of cells of the erythroid lineage (HP:0012130)3.44971757
14Lymphopenia (HP:0001888)3.42488952
15Cellulitis (HP:0100658)3.40099718
16Abnormality of cells of the lymphoid lineage (HP:0012140)3.33439191
17Onycholysis (HP:0001806)3.23905684
18Mediastinal lymphadenopathy (HP:0100721)2.95034150
19Recurrent pneumonia (HP:0006532)2.90435340
20Septate vagina (HP:0001153)2.89574558
21Hypertensive crisis (HP:0100735)2.88403999
22Urticaria (HP:0001025)2.87826821
23Aplastic anemia (HP:0001915)2.87634454
24Microretrognathia (HP:0000308)2.83530742
25Abnormality of T cell physiology (HP:0011840)2.82569173
26Vasculitis (HP:0002633)2.80546554
27Self-mutilation (HP:0000742)2.77934726
28IgG deficiency (HP:0004315)2.77316068
29Recurrent lower respiratory tract infections (HP:0002783)2.68553901
30Birth length less than 3rd percentile (HP:0003561)2.66953668
31Conical tooth (HP:0000698)2.64994731
32Skin rash (HP:0000988)2.63455788
33Chronic obstructive pulmonary disease (HP:0006510)2.63283498
34Obstructive lung disease (HP:0006536)2.63283498
35Broad distal phalanx of finger (HP:0009836)2.59479736
36Recurrent bacterial skin infections (HP:0005406)2.58173030
37Microvesicular hepatic steatosis (HP:0001414)2.55219828
38Abnormal mitochondria in muscle tissue (HP:0008316)2.49168362
39Ureteral stenosis (HP:0000071)2.47695503
40Abnormal gallbladder physiology (HP:0012438)2.43516923
41Cholecystitis (HP:0001082)2.43516923
42Acute necrotizing encephalopathy (HP:0006965)2.42827269
43Mitochondrial inheritance (HP:0001427)2.32729019
44Restrictive lung disease (HP:0002091)2.28591844
45Petechiae (HP:0000967)2.27435229
463-Methylglutaconic aciduria (HP:0003535)2.26545440
47Sparse scalp hair (HP:0002209)2.25539809
48Rib fusion (HP:0000902)2.24164456
49Dicarboxylic aciduria (HP:0003215)2.23097932
50Abnormality of dicarboxylic acid metabolism (HP:0010995)2.23097932
51Ureteral obstruction (HP:0006000)2.22388316
52Rectovaginal fistula (HP:0000143)2.22291046
53Rectal fistula (HP:0100590)2.22291046
54Acute encephalopathy (HP:0006846)2.19830619
55Optic nerve coloboma (HP:0000588)2.18785374
56Hepatocellular necrosis (HP:0001404)2.18724508
57Vaginal fistula (HP:0004320)2.17807725
58Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.16299162
59Breast hypoplasia (HP:0003187)2.16200648
60Ridged nail (HP:0001807)2.15848346
61Unilateral renal agenesis (HP:0000122)2.14525579
62Abnormality of the prostate (HP:0008775)2.10629871
63Recurrent skin infections (HP:0001581)2.07526569
64Cleft eyelid (HP:0000625)2.05563168
65Hepatic necrosis (HP:0002605)2.04262202
66Bronchitis (HP:0012387)2.03712231
67Progressive microcephaly (HP:0000253)2.01460077
68Verrucae (HP:0200043)2.01130834
69Papilloma (HP:0012740)2.01130834
70Recurrent otitis media (HP:0000403)1.97928208
71Increased CSF lactate (HP:0002490)1.94621324
72Methylmalonic aciduria (HP:0012120)1.91522927
73Abnormality of incisor morphology (HP:0011063)1.91380080
74Bicornuate uterus (HP:0000813)1.89880118
75Lipid accumulation in hepatocytes (HP:0006561)1.88654626
76Leukopenia (HP:0001882)1.86592048
77Panhypogammaglobulinemia (HP:0003139)1.84173131
78Intestinal fistula (HP:0100819)1.81645684
79Abnormal umbilical cord blood vessels (HP:0011403)1.80042302
80Single umbilical artery (HP:0001195)1.80042302
81Abnormality of the fetal cardiovascular system (HP:0010948)1.80042302
82Hyperthyroidism (HP:0000836)1.78055748
83B lymphocytopenia (HP:0010976)1.77769802
84Abnormality of male internal genitalia (HP:0000022)1.75833560
85Progressive muscle weakness (HP:0003323)1.74575966
86Progressive macrocephaly (HP:0004481)1.73942980
87Poor head control (HP:0002421)1.73910104
88Double outlet right ventricle (HP:0001719)1.72756073
89Congenital malformation of the right heart (HP:0011723)1.72756073
90Sepsis (HP:0100806)1.72684675
91Reticulocytopenia (HP:0001896)1.70537369
92Posterior embryotoxon (HP:0000627)1.70389635
93Long palpebral fissure (HP:0000637)1.69667134
94Decreased activity of mitochondrial respiratory chain (HP:0008972)1.69429338
95Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.69429338
96Abnormal delayed hypersensitivity skin test (HP:0002963)1.66444194
97Abnormality of the columella (HP:0009929)1.66398062
98Anal stenosis (HP:0002025)1.65435608
99Testicular atrophy (HP:0000029)1.63452697
100Recurrent abscess formation (HP:0002722)1.63031385

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK16.08037872
2ZAK5.63856290
3TLK15.45812244
4IRAK43.45176294
5VRK23.28217623
6DAPK33.07393818
7SMG12.92993500
8BCKDK2.83633606
9SIK12.65765629
10RPS6KA52.43923315
11AURKA2.16362931
12EEF2K2.06296861
13MAP4K11.88711625
14IRAK31.86471509
15ARAF1.75062154
16TAF11.74934101
17CDC71.73712339
18MAP3K101.64457683
19KDR1.40994341
20MAP3K111.30842459
21CASK1.29688751
22TNK21.27841756
23MAP3K91.27040218
24CHEK21.22898626
25STK41.22485279
26NME21.19616779
27IKBKB1.17688892
28MAP4K21.16802106
29BRAF1.07586749
30CSNK1G31.03833618
31CSNK1G20.98011344
32TBK10.94436964
33MAP3K130.94277938
34DYRK30.92975760
35PIM20.89377841
36MAPKAPK50.86098868
37CSNK1A1L0.86071150
38MAP2K70.83382187
39HIPK20.81355639
40AKT20.81296473
41CDK120.76718246
42AURKB0.76226210
43IRAK10.75495405
44NUAK10.74182704
45PRPF4B0.64851756
46ATR0.64690236
47ERN10.64267173
48MAPK150.62913310
49CDK70.62465269
50CDK80.61556582
51DYRK20.59599086
52CSNK1G10.58728472
53IRAK20.57429519
54CHUK0.56987354
55PKN10.56311958
56MAP2K20.56070019
57PIM10.54692364
58SYK0.54372049
59ICK0.53458957
60PRKCQ0.53350876
61BUB10.53116298
62MAPK110.52683631
63SIK20.52586037
64RPS6KB20.51298192
65CSF1R0.51270265
66TESK20.50964215
67MAP3K140.50630191
68RIPK40.49849137
69DAPK10.49260845
70IKBKE0.48848834
71MAP3K80.46143028
72CDK90.45008496
73BTK0.42226923
74OXSR10.41455670
75TAOK20.36908310
76NEK90.35134175
77LYN0.34094187
78RPS6KA40.33228864
79BLK0.32443870
80STK390.29034786
81ABL20.27663515
82MAPK130.26952328
83CDK20.26950284
84CCNB10.26597365
85PRKCD0.26284940
86CHEK10.26156172
87LMTK20.25671754
88RPS6KA60.25591747
89MAP3K10.23616587
90UHMK10.22968655
91MARK10.22939641
92RPS6KA10.22892180
93CDK40.22267548
94DDR20.21359186
95MAPKAPK30.21258154
96TAOK10.21073106
97MAPK40.20789513
98CSNK2A10.20109178
99PLK10.19870438
100MAPK120.18731711

Predicted pathways (KEGG)

RankGene SetZ-score
1Systemic lupus erythematosus_Homo sapiens_hsa053228.87833600
2Alcoholism_Homo sapiens_hsa050345.95416567
3Intestinal immune network for IgA production_Homo sapiens_hsa046723.57235752
4Allograft rejection_Homo sapiens_hsa053302.88212551
5Primary immunodeficiency_Homo sapiens_hsa053402.83386408
6Sulfur relay system_Homo sapiens_hsa041222.82754855
7Asthma_Homo sapiens_hsa053102.82504838
8Autoimmune thyroid disease_Homo sapiens_hsa053202.63267085
9Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.42009919
10Graft-versus-host disease_Homo sapiens_hsa053322.34735817
11Viral carcinogenesis_Homo sapiens_hsa052032.19136941
12Type I diabetes mellitus_Homo sapiens_hsa049402.07770042
13DNA replication_Homo sapiens_hsa030302.02164089
14Ribosome_Homo sapiens_hsa030101.88768012
15Transcriptional misregulation in cancer_Homo sapiens_hsa052021.84148496
16Viral myocarditis_Homo sapiens_hsa054161.75206109
17Base excision repair_Homo sapiens_hsa034101.60318198
18Oxidative phosphorylation_Homo sapiens_hsa001901.42342042
19Leishmaniasis_Homo sapiens_hsa051401.29909723
20Antigen processing and presentation_Homo sapiens_hsa046121.27752177
21Parkinsons disease_Homo sapiens_hsa050121.22537263
22Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.20245833
23Homologous recombination_Homo sapiens_hsa034401.19026266
24Spliceosome_Homo sapiens_hsa030401.18559652
25Maturity onset diabetes of the young_Homo sapiens_hsa049501.13752961
26B cell receptor signaling pathway_Homo sapiens_hsa046621.12499145
27Mismatch repair_Homo sapiens_hsa034301.06723892
28Phenylalanine metabolism_Homo sapiens_hsa003601.03472965
29Huntingtons disease_Homo sapiens_hsa050160.85917732
30Pyrimidine metabolism_Homo sapiens_hsa002400.85909939
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.85035272
32Biosynthesis of amino acids_Homo sapiens_hsa012300.84041614
33Fructose and mannose metabolism_Homo sapiens_hsa000510.83914814
34Pentose phosphate pathway_Homo sapiens_hsa000300.79035857
35Basal cell carcinoma_Homo sapiens_hsa052170.75814096
36Epstein-Barr virus infection_Homo sapiens_hsa051690.75277007
37Herpes simplex infection_Homo sapiens_hsa051680.73910689
38Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.71938499
39RNA polymerase_Homo sapiens_hsa030200.71731730
40Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.66596956
41Alzheimers disease_Homo sapiens_hsa050100.64782198
42Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.61480635
43Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.61433805
44Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.60795834
45Rheumatoid arthritis_Homo sapiens_hsa053230.60293150
46Staphylococcus aureus infection_Homo sapiens_hsa051500.60260644
47Nucleotide excision repair_Homo sapiens_hsa034200.58649775
482-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.56453362
49HTLV-I infection_Homo sapiens_hsa051660.56133941
50Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.55231261
51Carbon metabolism_Homo sapiens_hsa012000.53284579
52Proteasome_Homo sapiens_hsa030500.51534620
53Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.45753676
54Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.42974749
55Hedgehog signaling pathway_Homo sapiens_hsa043400.42395424
56p53 signaling pathway_Homo sapiens_hsa041150.42143219
57Fanconi anemia pathway_Homo sapiens_hsa034600.41928741
58Pyruvate metabolism_Homo sapiens_hsa006200.41639337
59Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.41376506
60Hematopoietic cell lineage_Homo sapiens_hsa046400.40530593
61Cysteine and methionine metabolism_Homo sapiens_hsa002700.36585599
62One carbon pool by folate_Homo sapiens_hsa006700.34796376
63Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.33728976
64Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.33602389
65Toxoplasmosis_Homo sapiens_hsa051450.31795519
66Tryptophan metabolism_Homo sapiens_hsa003800.31529452
67Notch signaling pathway_Homo sapiens_hsa043300.31085862
68Purine metabolism_Homo sapiens_hsa002300.31075957
69Tyrosine metabolism_Homo sapiens_hsa003500.30912276
70Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.30180467
71Selenocompound metabolism_Homo sapiens_hsa004500.29881660
72Influenza A_Homo sapiens_hsa051640.28900768
73Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.28771880
74Cell cycle_Homo sapiens_hsa041100.28222453
75Bladder cancer_Homo sapiens_hsa052190.27767667
76RNA degradation_Homo sapiens_hsa030180.27403046
77Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.25723528
78Arginine and proline metabolism_Homo sapiens_hsa003300.25312314
79Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.25311039
80NF-kappa B signaling pathway_Homo sapiens_hsa040640.23929373
81Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.23568075
82Galactose metabolism_Homo sapiens_hsa000520.23268806
83Tuberculosis_Homo sapiens_hsa051520.22954819
84Fatty acid biosynthesis_Homo sapiens_hsa000610.22426675
85Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.21301105
86Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.19687364
87Basal transcription factors_Homo sapiens_hsa030220.16930357
88Apoptosis_Homo sapiens_hsa042100.13669954
89Phagosome_Homo sapiens_hsa041450.13186426
90Cardiac muscle contraction_Homo sapiens_hsa042600.12013352
91Fatty acid elongation_Homo sapiens_hsa000620.10452663
92Metabolic pathways_Homo sapiens_hsa011000.10055121
93RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.07552566
94Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.07417590
95Butanoate metabolism_Homo sapiens_hsa006500.06856708
96Peroxisome_Homo sapiens_hsa041460.05844375
97Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.05500328
98Toll-like receptor signaling pathway_Homo sapiens_hsa046200.04137710
99Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.03648242
100Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.02675568

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