F8A3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is part of a region that is repeated three times on chromosome X, once in intron 22 of the F8 gene and twice closer to the Xq telomere. This record represents the most telomeric copy. Although its function is unknown, the observation that this gene is conserved in the mouse implies it has some function. Unlike factor VIII, this gene is transcribed abundantly in a wide variety of cell types. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.98314929
2negative regulation of cell killing (GO:0031342)4.93707130
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.93707130
4positive regulation of gamma-delta T cell activation (GO:0046645)4.81306799
5antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.70713384
6antigen processing and presentation of endogenous antigen (GO:0019883)4.67081193
7antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.63697808
8response to peptidoglycan (GO:0032494)4.62653295
9positive regulation by organism of defense response of other organism involved in symbiotic interact4.54339771
10modulation by symbiont of host immune response (GO:0052553)4.54339771
11positive regulation by symbiont of host defense response (GO:0052509)4.54339771
12modulation by symbiont of host defense response (GO:0052031)4.54339771
13modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.54339771
14modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.54339771
15negative regulation of erythrocyte differentiation (GO:0045647)4.31698618
16macrophage activation involved in immune response (GO:0002281)3.99645492
17neutrophil activation involved in immune response (GO:0002283)3.96574495
18negative regulation of interleukin-12 production (GO:0032695)3.96203182
19leukocyte aggregation (GO:0070486)3.94565234
20NIK/NF-kappaB signaling (GO:0038061)3.89985295
21detection of other organism (GO:0098543)3.87169044
22detection of bacterium (GO:0016045)3.84858983
23positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.67798865
24regulation of B cell receptor signaling pathway (GO:0050855)3.65449518
25regulation of interferon-beta biosynthetic process (GO:0045357)3.64105668
26positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.54493424
27type I interferon signaling pathway (GO:0060337)3.53640172
28cellular response to type I interferon (GO:0071357)3.53640172
29immunoglobulin mediated immune response (GO:0016064)3.53055847
30regulation of gamma-delta T cell activation (GO:0046643)3.51292928
31response to type I interferon (GO:0034340)3.50513139
32germinal center formation (GO:0002467)3.47169683
33response to muramyl dipeptide (GO:0032495)3.40856647
34response to host immune response (GO:0052572)3.40583902
35response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.40583902
36lipopolysaccharide-mediated signaling pathway (GO:0031663)3.38004311
37response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.26058098
38response to host (GO:0075136)3.26058098
39response to host defenses (GO:0052200)3.26058098
40detection of external biotic stimulus (GO:0098581)3.16186598
41defense response to protozoan (GO:0042832)3.09109002
42myeloid dendritic cell differentiation (GO:0043011)3.07498928
43B cell receptor signaling pathway (GO:0050853)3.05477645
44regulation of T-helper 2 cell differentiation (GO:0045628)3.04871371
45interferon-gamma-mediated signaling pathway (GO:0060333)3.03927265
46regulation of gamma-delta T cell differentiation (GO:0045586)2.97405639
47negative regulation of lymphocyte mediated immunity (GO:0002707)2.97342630
48negative regulation of leukocyte mediated immunity (GO:0002704)2.92074490
49regulation of T cell tolerance induction (GO:0002664)2.90919390
50positive thymic T cell selection (GO:0045059)2.90871011
51negative regulation of cytokine production involved in immune response (GO:0002719)2.90092711
52response to protozoan (GO:0001562)2.89781332
53detection of biotic stimulus (GO:0009595)2.86257996
54regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.84622565
55regulation of mast cell degranulation (GO:0043304)2.84603043
56regulation of type I interferon-mediated signaling pathway (GO:0060338)2.82675258
57cellular extravasation (GO:0045123)2.82280857
58positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.81573182
59regulation of leukocyte degranulation (GO:0043300)2.81515910
60tolerance induction (GO:0002507)2.80533168
61modulation by symbiont of host cellular process (GO:0044068)2.79310541
62detection of molecule of bacterial origin (GO:0032490)2.78262280
63granulocyte activation (GO:0036230)2.77478931
64antigen processing and presentation via MHC class Ib (GO:0002475)2.77068838
65positive regulation of B cell differentiation (GO:0045579)2.77059245
66myeloid cell activation involved in immune response (GO:0002275)2.77009314
67myeloid dendritic cell activation (GO:0001773)2.76699114
68thymic T cell selection (GO:0045061)2.75597153
69regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.75477996
70regulation of natural killer cell mediated immunity (GO:0002715)2.75477996
71regulation of interleukin-2 biosynthetic process (GO:0045076)2.74928516
72B cell mediated immunity (GO:0019724)2.73700005
73response to laminar fluid shear stress (GO:0034616)2.72254690
74positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.72112365
75response to interleukin-15 (GO:0070672)2.71328899
76neutrophil activation (GO:0042119)2.70534163
77regulation of interferon-alpha production (GO:0032647)2.70259116
78regulation of necroptotic process (GO:0060544)2.69873545
79CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.69509660
80positive regulation of interferon-alpha production (GO:0032727)2.68442525
81T cell selection (GO:0045058)2.68159634
82regulation of dendritic cell antigen processing and presentation (GO:0002604)2.67407136
83negative thymic T cell selection (GO:0045060)2.67114567
84negative regulation of T cell mediated immunity (GO:0002710)2.67076705
85T cell migration (GO:0072678)2.66189461
86regulation of podosome assembly (GO:0071801)2.65911525
87regulation of T-helper 1 cell differentiation (GO:0045625)2.65368221
88negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.64238018
89respiratory burst (GO:0045730)2.63834345
90positive regulation of immunoglobulin mediated immune response (GO:0002891)2.62784456
91positive regulation of B cell mediated immunity (GO:0002714)2.62784456
92regulation of myeloid leukocyte mediated immunity (GO:0002886)2.61784263
93protein localization to endosome (GO:0036010)2.61620596
94regulation of tolerance induction (GO:0002643)2.59431264
95negative regulation of innate immune response (GO:0045824)2.58330332
96mannose metabolic process (GO:0006013)2.57953707
97negative T cell selection (GO:0043383)2.57590663
98positive regulation of isotype switching (GO:0045830)2.56766808
99signal complex assembly (GO:0007172)2.56009734
100negative regulation of toll-like receptor signaling pathway (GO:0034122)2.55766823

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human3.85520921
2VDR_21846776_ChIP-Seq_THP-1_Human3.22510134
3MYC_22102868_ChIP-Seq_BL_Human3.12620268
4EGR1_19374776_ChIP-ChIP_THP-1_Human2.87204147
5IRF8_21731497_ChIP-ChIP_J774_Mouse2.80783808
6BP1_19119308_ChIP-ChIP_Hs578T_Human2.74170922
7NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.68348461
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.67968449
9NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.61128519
10STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.57338156
11SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.49232457
12NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.41476504
13KDM2B_26808549_Chip-Seq_SUP-B15_Human2.40763057
14VDR_24763502_ChIP-Seq_THP-1_Human2.39215379
15MAF_26560356_Chip-Seq_TH1_Human2.23132265
16MYB_21317192_ChIP-Seq_ERMYB_Mouse2.22803313
17KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.21275933
18TCF7_22412390_ChIP-Seq_EML_Mouse2.20747112
19FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.20511344
20THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.19680729
21ELK3_25401928_ChIP-Seq_HUVEC_Human2.18628929
22IRF8_27001747_Chip-Seq_BMDM_Mouse2.14306527
23LXR_22292898_ChIP-Seq_THP-1_Human2.12942939
24KDM2B_26808549_Chip-Seq_DND41_Human2.08447776
25STAT4_19710469_ChIP-ChIP_TH1__Mouse2.06644631
26SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.03846341
27E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.02325813
28RUNX1_22412390_ChIP-Seq_EML_Mouse1.99887597
29RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.98359677
30BRD4_27068464_Chip-Seq_AML-cells_Mouse1.96338584
31RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.94408974
32IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.91422227
33IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.89341189
34UTX_26944678_Chip-Seq_JUKART_Human1.88213070
35SPI1_23547873_ChIP-Seq_NB4_Human1.84353133
36MAF_26560356_Chip-Seq_TH2_Human1.80737201
37TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.80504094
38KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.79089794
39STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.75884833
40VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.72495303
41SPI1_23127762_ChIP-Seq_K562_Human1.72048066
42SCL_19346495_ChIP-Seq_HPC-7_Human1.67205954
43RACK7_27058665_Chip-Seq_MCF-7_Human1.62351397
44MYB_26560356_Chip-Seq_TH2_Human1.60008250
45STAT6_21828071_ChIP-Seq_BEAS2B_Human1.59638166
46FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.59247726
47RUNX_20019798_ChIP-Seq_JUKART_Human1.58397372
48MYB_26560356_Chip-Seq_TH1_Human1.51810174
49RARG_19884340_ChIP-ChIP_MEFs_Mouse1.50318871
50MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.49513143
51TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.48575860
52KDM2B_26808549_Chip-Seq_JURKAT_Human1.38751712
53PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.37363439
54SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.32369740
55GATA1_22383799_ChIP-Seq_G1ME_Mouse1.30383907
56TP63_17297297_ChIP-ChIP_HaCaT_Human1.29791133
57CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.29293994
58GATA1_19941827_ChIP-Seq_MEL_Mouse1.29270952
59CTCF_27219007_Chip-Seq_ERYTHROID_Human1.28233841
60Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.26006533
61TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.25805546
62KDM2B_26808549_Chip-Seq_K562_Human1.25292521
63FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.24368005
64GATA2_22383799_ChIP-Seq_G1ME_Mouse1.24229457
65PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.23542573
66PU.1_20513432_ChIP-Seq_Bcells_Mouse1.23067831
67CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.22568365
68PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.20898621
69KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.18109708
70STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.16273647
71SA1_27219007_Chip-Seq_ERYTHROID_Human1.16212850
72LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.14516900
73SRY_22984422_ChIP-ChIP_TESTIS_Rat1.12714733
74SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.12476623
75KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.11981084
76NCOR1_26117541_ChIP-Seq_K562_Human1.11695165
77ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.11333916
78EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.10714471
79SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.10483715
80RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.07680510
81BCOR_27268052_Chip-Seq_Bcells_Human1.07241614
82PU_27001747_Chip-Seq_BMDM_Mouse1.06359560
83GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06184050
84P300_27058665_Chip-Seq_ZR-75-30cells_Human1.05866598
85P68_20966046_ChIP-Seq_HELA_Human1.05622106
86CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03564281
87TET1_21451524_ChIP-Seq_MESCs_Mouse1.03209783
88ELF1_20517297_ChIP-Seq_JURKAT_Human1.02491434
89TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.01745980
90BCL6_27268052_Chip-Seq_Bcells_Human1.01659139
91TFEB_21752829_ChIP-Seq_HELA_Human0.99810018
92SMC4_20622854_ChIP-Seq_HELA_Human0.99366509
93NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.98001526
94CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97384446
95TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96860400
96GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.96595218
97VDR_24787735_ChIP-Seq_THP-1_Human0.96184571
98EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.95230311
99ESR2_21235772_ChIP-Seq_MCF-7_Human0.94137087
100GATA1_19941826_ChIP-Seq_K562_Human0.93238864

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation4.12644277
2MP0003436_decreased_susceptibility_to3.90957873
3MP0001835_abnormal_antigen_presentation3.17514528
4MP0003724_increased_susceptibility_to2.99548418
5MP0003300_gastrointestinal_ulcer2.84756218
6MP0005387_immune_system_phenotype2.78423966
7MP0001790_abnormal_immune_system2.78423966
8MP0000685_abnormal_immune_system2.72696291
9MP0005000_abnormal_immune_tolerance2.70732970
10MP0005671_abnormal_response_to2.62388520
11MP0004510_myositis2.60149044
12MP0009785_altered_susceptibility_to2.56387452
13MP0002419_abnormal_innate_immunity2.52649706
14MP0005451_abnormal_body_composition2.49894588
15MP0005025_abnormal_response_to2.45825439
16MP0001800_abnormal_humoral_immune2.44084925
17MP0003763_abnormal_thymus_physiology2.43210555
18MP0006082_CNS_inflammation2.37565143
19MP0005058_abnormal_lysosome_morphology2.37369749
20MP0002148_abnormal_hypersensitivity_rea2.35088715
21MP0002723_abnormal_immune_serum2.25051043
22MP0002452_abnormal_antigen_presenting2.20088360
23MP0002420_abnormal_adaptive_immunity2.14594660
24MP0001819_abnormal_immune_cell2.12497457
25MP0004947_skin_inflammation2.07019567
26MP0009333_abnormal_splenocyte_physiolog2.04365700
27MP0003191_abnormal_cellular_cholesterol1.97006940
28MP0001533_abnormal_skeleton_physiology1.93136707
29MP0005464_abnormal_platelet_physiology1.87613425
30MP0002405_respiratory_system_inflammati1.83313932
31MP0010155_abnormal_intestine_physiology1.81118586
32MP0002398_abnormal_bone_marrow1.78555944
33MP0003172_abnormal_lysosome_physiology1.76240907
34MP0003705_abnormal_hypodermis_morpholog1.75505637
35MP0008260_abnormal_autophagy1.68865832
36MP0000716_abnormal_immune_system1.67065538
37MP0009278_abnormal_bone_marrow1.61796684
38MP0001845_abnormal_inflammatory_respons1.60771214
39MP0000858_altered_metastatic_potential1.58244912
40MP0009840_abnormal_foam_cell1.57132187
41MP0005310_abnormal_salivary_gland1.53771146
42MP0003075_altered_response_to1.49374708
43MP0008004_abnormal_stomach_pH1.42180474
44MP0002998_abnormal_bone_remodeling1.41158112
45MP0002396_abnormal_hematopoietic_system1.40992107
46MP0002722_abnormal_immune_system1.40323101
47MP0000689_abnormal_spleen_morphology1.37710063
48MP0000703_abnormal_thymus_morphology1.37549489
49MP0002429_abnormal_blood_cell1.37272009
50MP0008469_abnormal_protein_level1.31355320
51MP0003091_abnormal_cell_migration1.30209264
52MP0003453_abnormal_keratinocyte_physiol1.28030693
53MP0001873_stomach_inflammation1.25832530
54MP0005076_abnormal_cell_differentiation1.23318881
55MP0002877_abnormal_melanocyte_morpholog1.20619642
56MP0004185_abnormal_adipocyte_glucose1.19696171
57MP0000343_altered_response_to1.18813880
58MP0004808_abnormal_hematopoietic_stem1.16946073
59MP0003448_altered_tumor_morphology1.16937594
60MP0003183_abnormal_peptide_metabolism1.13270901
61MP0003828_pulmonary_edema1.11999464
62MP0005166_decreased_susceptibility_to1.11740469
63MP0001853_heart_inflammation1.11694470
64MP0009764_decreased_sensitivity_to1.10484311
65MP0005666_abnormal_adipose_tissue1.07823027
66MP0001851_eye_inflammation1.05952558
67MP0003866_abnormal_defecation1.02908369
68MP0003279_aneurysm1.01195467
69MP0000490_abnormal_crypts_of1.00398300
70MP0000465_gastrointestinal_hemorrhage0.99126917
71MP0003566_abnormal_cell_adhesion0.99081666
72MP0001545_abnormal_hematopoietic_system0.98039368
73MP0005397_hematopoietic_system_phenotyp0.98039368
74MP0002166_altered_tumor_susceptibility0.97822466
75MP0002138_abnormal_hepatobiliary_system0.97568093
76MP0000604_amyloidosis0.93403307
77MP0001348_abnormal_lacrimal_gland0.90769550
78MP0005390_skeleton_phenotype0.90063785
79MP0001849_ear_inflammation0.88363663
80MP0004381_abnormal_hair_follicle0.83648128
81MP0005375_adipose_tissue_phenotype0.80423519
82MP0003690_abnormal_glial_cell0.79917018
83MP0009763_increased_sensitivity_to0.75978904
84MP0008874_decreased_physiological_sensi0.74486837
85MP0003045_fibrosis0.70975564
86MP0002332_abnormal_exercise_endurance0.70929882
87MP0002006_tumorigenesis0.70604257
88MP0002132_abnormal_respiratory_system0.69934936
89MP0005023_abnormal_wound_healing0.69478976
90MP0001663_abnormal_digestive_system0.68044300
91MP0004130_abnormal_muscle_cell0.67539276
92MP0003795_abnormal_bone_structure0.66628219
93MP0005621_abnormal_cell_physiology0.64539904
94MP0002933_joint_inflammation0.63434654
95MP0005164_abnormal_response_to0.63334552
96MP0005165_increased_susceptibility_to0.63140766
97MP0003656_abnormal_erythrocyte_physiolo0.62800065
98MP0010352_gastrointestinal_tract_polyps0.62640778
99MP0002254_reproductive_system_inflammat0.61611058
100MP0003806_abnormal_nucleotide_metabolis0.61255387

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)5.14385362
2Recurrent abscess formation (HP:0002722)4.57906725
3Recurrent bacterial skin infections (HP:0005406)4.46998465
4Abnormality of macrophages (HP:0004311)4.37084193
5Myositis (HP:0100614)4.00841032
6Orchitis (HP:0100796)3.73685207
7Mediastinal lymphadenopathy (HP:0100721)3.40380561
8Retrobulbar optic neuritis (HP:0100654)3.38086356
9Optic neuritis (HP:0100653)3.38086356
10Stomatitis (HP:0010280)3.21889496
11Abnormality of glycolipid metabolism (HP:0010969)3.21301380
12Abnormality of liposaccharide metabolism (HP:0010968)3.21301380
13Abnormality of glycosphingolipid metabolism (HP:0004343)3.21301380
14Elevated erythrocyte sedimentation rate (HP:0003565)3.17997925
15Recurrent gram-negative bacterial infections (HP:0005420)3.17140944
16Increased IgE level (HP:0003212)3.16834368
17Meningitis (HP:0001287)3.14963287
18Gastrointestinal infarctions (HP:0005244)3.11952058
19Cellulitis (HP:0100658)3.08705455
20Chronic obstructive pulmonary disease (HP:0006510)3.04536449
21Obstructive lung disease (HP:0006536)3.04536449
22Vasculitis (HP:0002633)3.02504684
23Recurrent viral infections (HP:0004429)2.99043561
24Gastrointestinal stroma tumor (HP:0100723)2.99033277
25Recurrent fungal infections (HP:0002841)2.92346098
26Increased cerebral lipofuscin (HP:0011813)2.87907628
27Spontaneous hematomas (HP:0007420)2.82382259
28Recurrent skin infections (HP:0001581)2.81536132
29Dysostosis multiplex (HP:0000943)2.73475863
30Gingivitis (HP:0000230)2.71140324
31Abnormal delayed hypersensitivity skin test (HP:0002963)2.70350195
32Loss of speech (HP:0002371)2.69732057
33Petechiae (HP:0000967)2.66507611
34Urticaria (HP:0001025)2.61155499
35Gastrointestinal inflammation (HP:0004386)2.53246629
36Encephalitis (HP:0002383)2.50511768
37Purpura (HP:0000979)2.45746221
38Prolonged bleeding time (HP:0003010)2.45318760
39Increased neuronal autofluorescent lipopigment (HP:0002074)2.44669248
40Inflammation of the large intestine (HP:0002037)2.43390399
41Pulmonary infiltrates (HP:0002113)2.42779929
42Chest pain (HP:0100749)2.42026110
43Colitis (HP:0002583)2.41481769
44Keratoconjunctivitis sicca (HP:0001097)2.38417366
45Emphysema (HP:0002097)2.36104433
46Lymphopenia (HP:0001888)2.34211816
47Increased IgM level (HP:0003496)2.30481611
48Chronic mucocutaneous candidiasis (HP:0002728)2.24498684
49Recurrent cutaneous fungal infections (HP:0011370)2.24498684
50Abnormality of cells of the lymphoid lineage (HP:0012140)2.20526488
51Increased serum ferritin (HP:0003281)2.19413622
52Slow saccadic eye movements (HP:0000514)2.17216817
53Epistaxis (HP:0000421)2.14435469
54Hemoptysis (HP:0002105)2.13802523
55Autoimmune thrombocytopenia (HP:0001973)2.13185914
56Osteomyelitis (HP:0002754)2.11841688
57Hypergammaglobulinemia (HP:0010702)2.10406926
58Hepatosplenomegaly (HP:0001433)2.10220436
59Hypertensive crisis (HP:0100735)2.08740993
60Keratoconjunctivitis (HP:0001096)2.08271917
61Pustule (HP:0200039)2.07427102
62Centrally nucleated skeletal muscle fibers (HP:0003687)2.05771238
63Restrictive lung disease (HP:0002091)2.05382035
64Autoimmune hemolytic anemia (HP:0001890)2.04899957
65Abnormality of mucopolysaccharide metabolism (HP:0011020)2.03696039
66Abnormality of polysaccharide metabolism (HP:0011012)2.03696039
67Abnormality of glycosaminoglycan metabolism (HP:0004371)2.03696039
68Polygenic inheritance (HP:0010982)2.03074371
69Arterial thrombosis (HP:0004420)2.01361595
70Systemic lupus erythematosus (HP:0002725)1.99291507
71Agammaglobulinemia (HP:0004432)1.98445958
72Gingival bleeding (HP:0000225)1.97394746
73Axonal loss (HP:0003447)1.96820164
74Panhypogammaglobulinemia (HP:0003139)1.96111118
75Interstitial pulmonary disease (HP:0006530)1.95498755
76Asymmetric septal hypertrophy (HP:0001670)1.95218373
77T lymphocytopenia (HP:0005403)1.95216741
78Fatigue (HP:0012378)1.94279995
79Premature loss of primary teeth (HP:0006323)1.94224114
80Urinary glycosaminoglycan excretion (HP:0003541)1.93674861
81Mucopolysacchariduria (HP:0008155)1.93674861
82Episodic fever (HP:0001954)1.93623507
83Anorexia (HP:0002039)1.93152849
84Amyloidosis (HP:0011034)1.89866961
85Vacuolated lymphocytes (HP:0001922)1.88550648
86Upper motor neuron abnormality (HP:0002127)1.87797964
87Abnormal platelet volume (HP:0011876)1.87590737
88Abnormality of T cells (HP:0002843)1.85771790
89Spondylolisthesis (HP:0003302)1.84865383
90Abnormality of skeletal muscle fiber size (HP:0012084)1.84731569
91Malnutrition (HP:0004395)1.84344535
92Sepsis (HP:0100806)1.84023959
93Abnormality of T cell physiology (HP:0011840)1.83786988
94Skin ulcer (HP:0200042)1.81480645
95Vertebral compression fractures (HP:0002953)1.79843089
96Hypertriglyceridemia (HP:0002155)1.79100448
97Granulocytopenia (HP:0001913)1.78978071
98Increased variability in muscle fiber diameter (HP:0003557)1.78643488
99Abnormality of the nasal mucosa (HP:0000433)1.78441263
100Distal lower limb amyotrophy (HP:0008944)1.78211617

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRPF4B3.90487319
2RIPK43.66565709
3MAP4K13.53871302
4ERN13.10946381
5TRIB33.00445641
6IRAK32.72922247
7SMG12.45288446
8IRAK42.40876088
9MAP2K32.35666425
10TYK22.09773982
11MAP3K141.95428733
12TAOK21.87099158
13MAP3K131.86827314
14TBK11.79580851
15MAP3K31.78901207
16SIK11.78272831
17SIK31.73181652
18CSK1.73176559
19NME21.71327565
20ZAP701.71003629
21BLK1.69310685
22MAP3K111.66586596
23TAOK11.60247233
24JAK31.42312105
25EPHB11.35375413
26ICK1.30703907
27IRAK21.28219284
28BTK1.27531638
29TNK21.23954503
30MAP3K11.23952465
31IKBKE1.21775221
32FES1.20945610
33RIPK11.19109917
34GRK61.18504328
35CDK121.18321704
36SIK21.16715266
37SYK1.15491420
38JAK11.12137270
39HCK1.10705110
40CDC42BPA1.08381062
41KSR21.05383050
42TTN1.04244848
43IKBKB1.02277268
44FGR0.98764017
45MAP3K100.97666567
46PDPK10.91123145
47MARK20.90088724
48PRKD20.88399558
49PDK10.87766378
50CSF1R0.87713957
51HIPK20.86824714
52TXK0.86663344
53EEF2K0.83710371
54FGFR40.82374413
55LYN0.79960662
56MAPK120.79606859
57JAK20.79214895
58MARK30.79044087
59ARAF0.78489103
60MAPK110.77376927
61MATK0.75184917
62BMPR20.74691124
63LCK0.74237307
64STK100.73620911
65PRKD30.70337084
66MOS0.69021274
67ITK0.68252559
68LRRK20.68156235
69MAPK70.67802233
70NEK90.66349080
71IRAK10.64693800
72CDK40.64531787
73TGFBR20.61391062
74PTK60.60965437
75RPS6KC10.58976050
76RPS6KL10.58976050
77MAP3K80.58519437
78PKN20.57188375
79CAMKK10.56702347
80TESK10.55885226
81GRK70.55224403
82PRKG20.53544332
83DDR20.52413823
84MAP3K90.51262601
85TESK20.49529800
86CDK60.45522373
87RPS6KA20.44088830
88MAPK40.43811710
89PAK40.43708049
90PRKCH0.41355252
91CHUK0.40952554
92KIT0.40153008
93YES10.39957608
94BRAF0.39722844
95RPS6KA60.38920570
96MAP3K60.38688712
97MELK0.38176111
98FYN0.38147571
99MAP2K60.37133331
100MAPKAPK20.37055686

Predicted pathways (KEGG)

RankGene SetZ-score
1Osteoclast differentiation_Homo sapiens_hsa043802.70531578
2Leishmaniasis_Homo sapiens_hsa051402.53852928
3Allograft rejection_Homo sapiens_hsa053302.36786674
4B cell receptor signaling pathway_Homo sapiens_hsa046622.33051466
5Toll-like receptor signaling pathway_Homo sapiens_hsa046202.23673505
6Graft-versus-host disease_Homo sapiens_hsa053322.18337523
7Autoimmune thyroid disease_Homo sapiens_hsa053202.04419767
8NF-kappa B signaling pathway_Homo sapiens_hsa040642.01658675
9Other glycan degradation_Homo sapiens_hsa005111.96593949
10Acute myeloid leukemia_Homo sapiens_hsa052211.90315131
11Primary immunodeficiency_Homo sapiens_hsa053401.87662452
12Staphylococcus aureus infection_Homo sapiens_hsa051501.86344442
13Tuberculosis_Homo sapiens_hsa051521.83180810
14Measles_Homo sapiens_hsa051621.70328506
15Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.69569171
16Type I diabetes mellitus_Homo sapiens_hsa049401.69367541
17TNF signaling pathway_Homo sapiens_hsa046681.65801207
18T cell receptor signaling pathway_Homo sapiens_hsa046601.65150294
19Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.63932404
20Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.63389056
21Viral myocarditis_Homo sapiens_hsa054161.62698031
22Asthma_Homo sapiens_hsa053101.61004401
23Toxoplasmosis_Homo sapiens_hsa051451.58582956
24Influenza A_Homo sapiens_hsa051641.58228706
25Intestinal immune network for IgA production_Homo sapiens_hsa046721.58155650
26Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.55806459
27RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.52947732
28Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.52358664
29Herpes simplex infection_Homo sapiens_hsa051681.51235548
30Hematopoietic cell lineage_Homo sapiens_hsa046401.48115999
31Antigen processing and presentation_Homo sapiens_hsa046121.44657136
32Malaria_Homo sapiens_hsa051441.44457224
33Chronic myeloid leukemia_Homo sapiens_hsa052201.43144862
34NOD-like receptor signaling pathway_Homo sapiens_hsa046211.42318962
35Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.39203964
36Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.35799020
37Non-small cell lung cancer_Homo sapiens_hsa052231.34887639
38Hepatitis B_Homo sapiens_hsa051611.33824616
39Chemokine signaling pathway_Homo sapiens_hsa040621.29061157
40Pancreatic cancer_Homo sapiens_hsa052121.24648495
41Hepatitis C_Homo sapiens_hsa051601.24632534
42VEGF signaling pathway_Homo sapiens_hsa043701.18202458
43Legionellosis_Homo sapiens_hsa051341.17221604
44Lysosome_Homo sapiens_hsa041421.16937620
45Jak-STAT signaling pathway_Homo sapiens_hsa046301.15033855
46Pertussis_Homo sapiens_hsa051331.12248243
47Salmonella infection_Homo sapiens_hsa051321.10414482
48Rheumatoid arthritis_Homo sapiens_hsa053231.09148174
49Shigellosis_Homo sapiens_hsa051311.07668505
50Apoptosis_Homo sapiens_hsa042101.07270860
51Phagosome_Homo sapiens_hsa041451.05918582
52Neurotrophin signaling pathway_Homo sapiens_hsa047221.03174762
53African trypanosomiasis_Homo sapiens_hsa051431.01751912
54Leukocyte transendothelial migration_Homo sapiens_hsa046701.01342437
55AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.98364245
56Glycosaminoglycan degradation_Homo sapiens_hsa005310.96568373
57Notch signaling pathway_Homo sapiens_hsa043300.95870555
58Renal cell carcinoma_Homo sapiens_hsa052110.94065191
59Epstein-Barr virus infection_Homo sapiens_hsa051690.93863863
60HTLV-I infection_Homo sapiens_hsa051660.91572283
61Prolactin signaling pathway_Homo sapiens_hsa049170.90041525
62Bladder cancer_Homo sapiens_hsa052190.89459915
63Platelet activation_Homo sapiens_hsa046110.88765785
64Prion diseases_Homo sapiens_hsa050200.82543013
65Amoebiasis_Homo sapiens_hsa051460.81621850
66Adipocytokine signaling pathway_Homo sapiens_hsa049200.79781853
67Sphingolipid signaling pathway_Homo sapiens_hsa040710.78502731
68Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.77189281
69Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.76208490
70Viral carcinogenesis_Homo sapiens_hsa052030.75307646
71Endometrial cancer_Homo sapiens_hsa052130.73163319
72Endocytosis_Homo sapiens_hsa041440.72133425
73Pentose phosphate pathway_Homo sapiens_hsa000300.70985647
74mTOR signaling pathway_Homo sapiens_hsa041500.69247552
75Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.68342521
76Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.67421267
77Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.67225984
78Phospholipase D signaling pathway_Homo sapiens_hsa040720.67061681
79Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.66443096
80GnRH signaling pathway_Homo sapiens_hsa049120.63318119
81Glioma_Homo sapiens_hsa052140.63234640
82Insulin resistance_Homo sapiens_hsa049310.60845418
83Prostate cancer_Homo sapiens_hsa052150.58832089
84Thyroid cancer_Homo sapiens_hsa052160.56432595
85Phosphatidylinositol signaling system_Homo sapiens_hsa040700.56030964
86Insulin signaling pathway_Homo sapiens_hsa049100.55624199
87Small cell lung cancer_Homo sapiens_hsa052220.54342358
88Central carbon metabolism in cancer_Homo sapiens_hsa052300.51316022
89ErbB signaling pathway_Homo sapiens_hsa040120.51293341
90Colorectal cancer_Homo sapiens_hsa052100.50781297
91FoxO signaling pathway_Homo sapiens_hsa040680.50136308
92SNARE interactions in vesicular transport_Homo sapiens_hsa041300.50126892
93HIF-1 signaling pathway_Homo sapiens_hsa040660.49058246
94MAPK signaling pathway_Homo sapiens_hsa040100.47847447
95Inositol phosphate metabolism_Homo sapiens_hsa005620.47490159
96Galactose metabolism_Homo sapiens_hsa000520.47480473
97Longevity regulating pathway - mammal_Homo sapiens_hsa042110.41780040
98Fructose and mannose metabolism_Homo sapiens_hsa000510.41451379
99Choline metabolism in cancer_Homo sapiens_hsa052310.40535900
100Proteoglycans in cancer_Homo sapiens_hsa052050.39770828

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