FA2H

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that catalyzes the synthesis of 2-hydroxysphingolipids, a subset of sphingolipids that contain 2-hydroxy fatty acids. Sphingolipids play roles in many cellular processes and their structural diversity arises from modification of the hydrophobic ceramide moiety, such as by 2-hydroxylation of the N-acyl chain, and the existence of many different head groups. Mutations in this gene have been associated with leukodystrophy dysmyelinating with spastic paraparesis with or without dystonia. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fatty acid elongation (GO:0030497)8.75987751
2ensheathment of neurons (GO:0007272)7.06175677
3axon ensheathment (GO:0008366)7.06175677
4myelination (GO:0042552)6.91775343
5synaptic vesicle docking involved in exocytosis (GO:0016081)6.66990833
6glutamate secretion (GO:0014047)6.32629266
7long-chain fatty acid biosynthetic process (GO:0042759)6.28871508
8synaptic vesicle maturation (GO:0016188)6.10074299
9sodium ion export (GO:0071436)5.88667327
10cellular potassium ion homeostasis (GO:0030007)5.73373257
11synaptic vesicle exocytosis (GO:0016079)5.67052283
12cholesterol biosynthetic process (GO:0006695)5.13189117
13response to methylmercury (GO:0051597)4.99392993
14negative regulation of neurotransmitter transport (GO:0051589)4.90602850
15regulation of synaptic vesicle exocytosis (GO:2000300)4.82831984
16regulation of short-term neuronal synaptic plasticity (GO:0048172)4.82148365
17negative regulation of neurotransmitter secretion (GO:0046929)4.82040613
18establishment of mitochondrion localization (GO:0051654)4.69065107
19long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)4.61823762
20oligodendrocyte differentiation (GO:0048709)4.55951513
21sterol biosynthetic process (GO:0016126)4.54566514
22creatine metabolic process (GO:0006600)4.51411612
23negative regulation of protein localization to cell surface (GO:2000009)4.51093825
24potassium ion homeostasis (GO:0055075)4.46208922
25* myelin maintenance (GO:0043217)4.42276501
26amyloid precursor protein metabolic process (GO:0042982)4.41852968
27neurotransmitter secretion (GO:0007269)4.34065520
28long-chain fatty-acyl-CoA metabolic process (GO:0035336)4.33244055
29positive regulation of synapse maturation (GO:0090129)4.27740585
30L-amino acid import (GO:0043092)4.21351982
31regulation of collateral sprouting (GO:0048670)4.19872584
32regulation of neuronal synaptic plasticity (GO:0048168)4.18396653
33apical protein localization (GO:0045176)4.15457583
34positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.09977205
35eye photoreceptor cell differentiation (GO:0001754)4.08772946
36photoreceptor cell differentiation (GO:0046530)4.08772946
37asymmetric protein localization (GO:0008105)4.08478775
38cytoskeletal anchoring at plasma membrane (GO:0007016)4.07502893
39regulation of synaptic vesicle transport (GO:1902803)4.04432326
40fatty-acyl-CoA biosynthetic process (GO:0046949)4.03356488
41isoprenoid biosynthetic process (GO:0008299)4.00350347
42glycerophospholipid catabolic process (GO:0046475)3.95049890
43potassium ion import (GO:0010107)3.94951054
44membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.93726306
45positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.93191098
46positive regulation of oligodendrocyte differentiation (GO:0048714)3.90623509
47peptidyl-tyrosine autophosphorylation (GO:0038083)3.90038934
48import into cell (GO:0098657)3.87483882
49cerebellar granule cell differentiation (GO:0021707)3.83567406
50cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.82666178
51response to lipoprotein particle (GO:0055094)3.80940940
52vocalization behavior (GO:0071625)3.78843384
53astrocyte development (GO:0014002)3.74653111
54fatty-acyl-CoA metabolic process (GO:0035337)3.74146848
55regulation of lipoprotein metabolic process (GO:0050746)3.63002648
56neurotransmitter transport (GO:0006836)3.60938558
57presynaptic membrane organization (GO:0097090)3.60001495
58regulation of long-term neuronal synaptic plasticity (GO:0048169)3.59250991
59locomotory exploration behavior (GO:0035641)3.56010351
60substantia nigra development (GO:0021762)3.54694073
61regulation of synaptic plasticity (GO:0048167)3.50911375
62cellular sodium ion homeostasis (GO:0006883)3.49680070
63very long-chain fatty acid metabolic process (GO:0000038)3.45340693
64myelination in peripheral nervous system (GO:0022011)3.45064927
65peripheral nervous system axon ensheathment (GO:0032292)3.45064927
66regulation of ARF protein signal transduction (GO:0032012)3.43340468
67adult walking behavior (GO:0007628)3.37396683
68ionotropic glutamate receptor signaling pathway (GO:0035235)3.35782101
69protein palmitoylation (GO:0018345)3.35711051
70membrane tubulation (GO:0097320)3.33232048
71regulation of neurotransmitter levels (GO:0001505)3.29551160
72thioester biosynthetic process (GO:0035384)3.25037065
73acyl-CoA biosynthetic process (GO:0071616)3.25037065
74response to redox state (GO:0051775)3.21855026
75regulation of female receptivity (GO:0045924)3.20763115
76glycosylceramide metabolic process (GO:0006677)3.20442924
77neuromuscular process controlling balance (GO:0050885)3.19531098
78magnesium ion transport (GO:0015693)3.19390952
79neuron remodeling (GO:0016322)3.19269666
80acidic amino acid transport (GO:0015800)3.19204671
81regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.18115919
82regulation of synapse maturation (GO:0090128)3.15818061
83negative regulation of synaptic transmission, GABAergic (GO:0032229)3.15672028
84desmosome organization (GO:0002934)3.15008746
85cell communication by electrical coupling (GO:0010644)3.14991183
86glycine transport (GO:0015816)3.14392658
87negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.13283744
88synaptic vesicle endocytosis (GO:0048488)3.09281296
89negative regulation of dendrite morphogenesis (GO:0050774)3.08138868
90amino acid import (GO:0043090)3.07392529
91long-term synaptic potentiation (GO:0060291)3.07378837
92axon development (GO:0061564)3.05637061
93negative regulation of execution phase of apoptosis (GO:1900118)3.05284051
94amyloid precursor protein catabolic process (GO:0042987)3.05131123
95presynaptic membrane assembly (GO:0097105)3.01781499
96cell communication involved in cardiac conduction (GO:0086065)2.99756242
97exploration behavior (GO:0035640)2.98383741
98negative regulation of axonogenesis (GO:0050771)2.98008535
99regulation of cholesterol biosynthetic process (GO:0045540)2.95443427
100regulation of glutamate receptor signaling pathway (GO:1900449)2.94392530
101positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.91549232
102GPI anchor biosynthetic process (GO:0006506)2.88754568
103enteric nervous system development (GO:0048484)2.87737759
104peripheral nervous system development (GO:0007422)2.87415153
105L-glutamate transport (GO:0015813)2.86831586
106neurotransmitter uptake (GO:0001504)2.85064306
107neuronal action potential propagation (GO:0019227)2.84343887
108positive regulation of dendritic spine development (GO:0060999)2.84304344
109positive regulation of membrane potential (GO:0045838)2.84195867
110GPI anchor metabolic process (GO:0006505)2.81843331
111nerve growth factor signaling pathway (GO:0038180)2.81221539
112activation of Rac GTPase activity (GO:0032863)2.80494012
113peptidyl-cysteine modification (GO:0018198)2.80336791
114layer formation in cerebral cortex (GO:0021819)2.79487353
115regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.79293643
116detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.78413229
117detection of temperature stimulus involved in sensory perception (GO:0050961)2.78413229
118adhesion of symbiont to host cell (GO:0044650)2.78055718
119virion attachment to host cell (GO:0019062)2.78055718
120negative regulation of inclusion body assembly (GO:0090084)2.77327013
121iron coordination entity transport (GO:1901678)2.77255506
122regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.75570218
123female mating behavior (GO:0060180)2.75114350
124regulation of neurotransmitter secretion (GO:0046928)2.75110967
125cerebral cortex radially oriented cell migration (GO:0021799)2.74997123
126negative regulation of hydrogen peroxide-induced cell death (GO:1903206)2.73687193
127synaptic transmission, glutamatergic (GO:0035249)2.73371445
128regulation of dendritic spine morphogenesis (GO:0061001)2.71024109
129regulation of voltage-gated calcium channel activity (GO:1901385)2.69713294
130dendritic spine organization (GO:0097061)2.69660903
131G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.68883213
132dicarboxylic acid transport (GO:0006835)2.68852711
133limb bud formation (GO:0060174)2.68563550
134cerebellar Purkinje cell layer development (GO:0021680)2.67672716
135negative regulation of macroautophagy (GO:0016242)2.67650439
136postsynaptic membrane organization (GO:0001941)2.67086664
137positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.66466512
138microtubule polymerization or depolymerization (GO:0031109)2.65700486
139heme transport (GO:0015886)2.65430496
140positive regulation of gliogenesis (GO:0014015)2.64655674
141positive regulation of glial cell differentiation (GO:0045687)2.63903018
142preassembly of GPI anchor in ER membrane (GO:0016254)2.61528510
143substrate-independent telencephalic tangential migration (GO:0021826)2.61200161
144substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.61200161
145sodium ion homeostasis (GO:0055078)2.59882392
146negative regulation of JUN kinase activity (GO:0043508)2.59550901
147gamma-aminobutyric acid signaling pathway (GO:0007214)2.59411371
148long term synaptic depression (GO:0060292)2.58277537
149extracellular matrix assembly (GO:0085029)2.58137390
150long-term memory (GO:0007616)2.57789344
151organ growth (GO:0035265)2.55329846
152regulation of hydrogen peroxide-induced cell death (GO:1903205)2.54748302
153regulation of clathrin-mediated endocytosis (GO:2000369)2.54747622
154regulation of excitatory postsynaptic membrane potential (GO:0060079)2.54661112
155protein localization to endosome (GO:0036010)2.54248181
156Golgi to endosome transport (GO:0006895)2.53986223
157regulation of synaptic transmission (GO:0050804)2.53082506
158glial cell differentiation (GO:0010001)2.51835264
159glial cell development (GO:0021782)2.51045430
160response to lead ion (GO:0010288)2.51038279
161positive regulation of pseudopodium assembly (GO:0031274)2.50924459
162membrane hyperpolarization (GO:0060081)2.49544085
163regulation of somitogenesis (GO:0014807)2.49212802
164regulation of neurotransmitter transport (GO:0051588)2.48993258
165neuron cell-cell adhesion (GO:0007158)2.48879704
166transmission of nerve impulse (GO:0019226)2.48849302
167nucleotide transmembrane transport (GO:1901679)2.48191914
168acid secretion (GO:0046717)2.47720379
169neuronal ion channel clustering (GO:0045161)2.46633159
170cardiac conduction (GO:0061337)2.45952396
171negative regulation of axon extension (GO:0030517)2.45720420
172one-carbon compound transport (GO:0019755)2.45581778
173glutamate receptor signaling pathway (GO:0007215)2.45373802
174regulation of vesicle fusion (GO:0031338)2.45359900
175negative regulation of response to reactive oxygen species (GO:1901032)2.45103714
176regulation of dendritic spine development (GO:0060998)2.44957507
177activation of protein kinase A activity (GO:0034199)2.43398286
178positive regulation of Rap GTPase activity (GO:0032854)2.42280695
179positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)2.41997137
180phosphatidylserine acyl-chain remodeling (GO:0036150)2.41794301
181central nervous system myelination (GO:0022010)11.9300345
182axon ensheathment in central nervous system (GO:0032291)11.9300345

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.32985834
2EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse3.18941109
3THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse3.04808430
4TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.88518777
5GBX2_23144817_ChIP-Seq_PC3_Human2.75154145
6MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.74389933
7TP63_17297297_ChIP-ChIP_HaCaT_Human2.69355293
8* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.54490589
9EZH2_22144423_ChIP-Seq_EOC_Human2.49640523
10LXR_22292898_ChIP-Seq_THP-1_Human2.46329060
11SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.25604184
12* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.25167359
13KDM2B_26808549_Chip-Seq_K562_Human2.22529445
14AR_21572438_ChIP-Seq_LNCaP_Human2.12923503
15NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.12922704
16JARID2_20064375_ChIP-Seq_MESCs_Mouse2.12081272
17SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.11328672
18ESR1_21235772_ChIP-Seq_MCF-7_Human2.04775377
19ERG_21242973_ChIP-ChIP_JURKAT_Human2.02761997
20RACK7_27058665_Chip-Seq_MCF-7_Human2.01822938
21* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.01332176
22* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.00546654
23DNAJC2_21179169_ChIP-ChIP_NT2_Human1.99182945
24OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.98988046
25EZH2_18974828_ChIP-Seq_MESCs_Mouse1.97264705
26RNF2_18974828_ChIP-Seq_MESCs_Mouse1.97264705
27VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.94404707
28SUZ12_27294783_Chip-Seq_ESCs_Mouse1.93354797
29SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.91502490
30* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.88873472
31EZH2_27294783_Chip-Seq_ESCs_Mouse1.88292903
32TAF15_26573619_Chip-Seq_HEK293_Human1.87582283
33EZH2_27304074_Chip-Seq_ESCs_Mouse1.86713028
34SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.79040494
35SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.78472756
36CDX2_20551321_ChIP-Seq_CACO-2_Human1.77895296
37EED_16625203_ChIP-ChIP_MESCs_Mouse1.74381723
38KDM2B_26808549_Chip-Seq_SUP-B15_Human1.73504981
39CDX2_19796622_ChIP-Seq_MESCs_Mouse1.72134924
40JARID2_20075857_ChIP-Seq_MESCs_Mouse1.71881077
41ZNF263_19887448_ChIP-Seq_K562_Human1.71759498
42CTCF_27219007_Chip-Seq_Bcells_Human1.69070527
43* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.68960208
44ZFP57_27257070_Chip-Seq_ESCs_Mouse1.62224247
45SMC4_20622854_ChIP-Seq_HELA_Human1.61900130
46SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.61395097
47DROSHA_22980978_ChIP-Seq_HELA_Human1.60414142
48CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.57708916
49* RNF2_27304074_Chip-Seq_ESCs_Mouse1.56452510
50RARG_19884340_ChIP-ChIP_MEFs_Mouse1.53417677
51CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.51893003
52TET1_21490601_ChIP-Seq_MESCs_Mouse1.51573055
53ER_23166858_ChIP-Seq_MCF-7_Human1.50404022
54VDR_22108803_ChIP-Seq_LS180_Human1.46642690
55CREB1_26743006_Chip-Seq_LNCaP_Human1.44403953
56SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.43519205
57STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.42265720
58P68_20966046_ChIP-Seq_HELA_Human1.42172080
59ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.42030638
60CBX2_27304074_Chip-Seq_ESCs_Mouse1.40626464
61UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.40550584
62PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.39704564
63ZFP281_27345836_Chip-Seq_ESCs_Mouse1.39676393
64SOX2_27498859_Chip-Seq_STOMACH_Mouse1.39085118
65RUNX1_27514584_Chip-Seq_MCF-7_Human1.38109438
66SMAD3_21741376_ChIP-Seq_EPCs_Human1.37281018
67GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37088119
68WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.36702430
69RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.35922610
70RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.34926699
71TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34594192
72SRY_22984422_ChIP-ChIP_TESTIS_Rat1.34280573
73RARB_27405468_Chip-Seq_BRAIN_Mouse1.34109226
74CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.33613002
75* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.33356790
76RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.29865592
77SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.27603676
78IKZF1_21737484_ChIP-ChIP_HCT116_Human1.26467034
79ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.25733134
80KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.25715584
81NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.25588415
82E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.24809228
83KDM2B_26808549_Chip-Seq_DND41_Human1.23555290
84PIAS1_25552417_ChIP-Seq_VCAP_Human1.22472542
85TET1_21451524_ChIP-Seq_MESCs_Mouse1.22341597
86PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.21665218
87CTBP1_25329375_ChIP-Seq_LNCAP_Human1.19657188
88GATA1_26923725_Chip-Seq_HPCs_Mouse1.17457924
89LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17356937
90PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.17346615
91POU3F2_20337985_ChIP-ChIP_501MEL_Human1.17053003
92SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.16457160
93TP63_22573176_ChIP-Seq_HFKS_Human1.15162740
94EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.14947092
95CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.14819141
96ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.14796460
97SOX2_20726797_ChIP-Seq_SW620_Human1.13471741
98* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.12307398
99CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.12092790
100CTCF_20526341_ChIP-Seq_ESCs_Human1.11312099
101OCT4_19829295_ChIP-Seq_ESCs_Human1.10812498
102SA1_27219007_Chip-Seq_ERYTHROID_Human1.10712126
103NRF2_20460467_ChIP-Seq_MEFs_Mouse1.10357764
104NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.10357764
105WT1_25993318_ChIP-Seq_PODOCYTE_Human1.10211487
106KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.09591818
107EP300_21415370_ChIP-Seq_HL-1_Mouse1.09452826
108REST_21632747_ChIP-Seq_MESCs_Mouse1.08622953
109* KLF5_25053715_ChIP-Seq_YYC3_Human1.08612097
110PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.08352219
111TAL1_26923725_Chip-Seq_HPCs_Mouse1.07314587
112P53_22127205_ChIP-Seq_FIBROBLAST_Human1.06949258
113SA1_27219007_Chip-Seq_Bcells_Human1.06884058
114CTBP2_25329375_ChIP-Seq_LNCAP_Human1.05737761
115SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.05338657
116HTT_18923047_ChIP-ChIP_STHdh_Human1.05204035
117ESR1_20079471_ChIP-ChIP_T-47D_Human1.04275201
118OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.03756471
119CTCF_27219007_Chip-Seq_ERYTHROID_Human1.03651096
120PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.03556279
121TCF7_22412390_ChIP-Seq_EML_Mouse1.02443217
122CTNNB1_20460455_ChIP-Seq_HCT116_Human1.02256143
123ZNF217_24962896_ChIP-Seq_MCF-7_Human1.02050194
124* STAT3_23295773_ChIP-Seq_U87_Human1.01944571
125* P300_19829295_ChIP-Seq_ESCs_Human1.01396032
126P300_27058665_Chip-Seq_ZR-75-30cells_Human1.01137205
127ARNT_22903824_ChIP-Seq_MCF-7_Human1.01050826
128SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.00427361
129EOMES_21245162_ChIP-Seq_HESCs_Human1.00302255
130ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.99837814
131PRDM14_20953172_ChIP-Seq_ESCs_Human0.99749669
132GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.99476302
133ESR2_21235772_ChIP-Seq_MCF-7_Human0.98819903
134ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.98787715
135FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.98656726
136KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.97651993
137RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97616186
138CMYC_18555785_Chip-Seq_ESCs_Mouse0.97254898
139SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.96462960
140GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96446995
141AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.96224898
142AHR_22903824_ChIP-Seq_MCF-7_Human0.96082311
143BCOR_27268052_Chip-Seq_Bcells_Human0.96021204
144PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.95454853
145PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.94350623
146NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.94181381
147P63_26484246_Chip-Seq_KERATINOCYTES_Human0.94123584
148LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93547948
149FUS_26573619_Chip-Seq_HEK293_Human0.93169772
150SUZ12_18555785_Chip-Seq_ESCs_Mouse0.91435900
151NANOG_18555785_Chip-Seq_ESCs_Mouse0.91058658
152GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.90592281
153P300_18555785_Chip-Seq_ESCs_Mouse0.89903444
154WT1_19549856_ChIP-ChIP_CCG9911_Human0.89282592
155UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.89269864
156NR3C1_21868756_ChIP-Seq_MCF10A_Human0.88853142
157RING1B_27294783_Chip-Seq_ESCs_Mouse0.88565254
158TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.88371319
159MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.88203544
160TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.88181466
161RING1B_27294783_Chip-Seq_NPCs_Mouse0.87976713
162TOP2B_26459242_ChIP-Seq_MCF-7_Human0.87559957
163* REST_18959480_ChIP-ChIP_MESCs_Mouse0.87260228
164* TCF4_23295773_ChIP-Seq_U87_Human0.87150774
165SMAD4_21799915_ChIP-Seq_A2780_Human0.86991145
166ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.86766515
167MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.86689543
168TP53_16413492_ChIP-PET_HCT116_Human0.86637353
169TRIM28_21343339_ChIP-Seq_HEK293_Human0.85892134
170TBL1_22424771_ChIP-Seq_293T_Human0.85585155
171TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.84874992

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000920_abnormal_myelination5.71906191
2MP0003950_abnormal_plasma_membrane3.94017975
3MP0010234_abnormal_vibrissa_follicle3.81779641
4MP0003880_abnormal_central_pattern3.69663036
5MP0004270_analgesia3.29720764
6MP0004885_abnormal_endolymph3.05567910
7MP0003690_abnormal_glial_cell2.95296077
8MP0003329_amyloid_beta_deposits2.85376876
9MP0005171_absent_coat_pigmentation2.80351243
10MP0001529_abnormal_vocalization2.68645868
11MP0009780_abnormal_chondrocyte_physiolo2.64553924
12MP0002272_abnormal_nervous_system2.54103687
13MP0004742_abnormal_vestibular_system2.47248481
14MP0003879_abnormal_hair_cell2.44576063
15MP0001486_abnormal_startle_reflex2.41509222
16MP0003634_abnormal_glial_cell2.34675819
17MP0004142_abnormal_muscle_tone2.32143456
18MP0005410_abnormal_fertilization2.22555551
19MP0001905_abnormal_dopamine_level2.22286450
20MP0010678_abnormal_skin_adnexa2.21017115
21MP0003136_yellow_coat_color2.10437160
22MP0002064_seizures2.07743147
23MP0005409_darkened_coat_color2.07722683
24MP0004381_abnormal_hair_follicle2.05297499
25MP0000778_abnormal_nervous_system1.98622866
26MP0001485_abnormal_pinna_reflex1.98162314
27MP0000383_abnormal_hair_follicle1.96686749
28MP0004859_abnormal_synaptic_plasticity1.96212874
29MP0005451_abnormal_body_composition1.93271957
30MP0005423_abnormal_somatic_nervous1.92794056
31MP0002229_neurodegeneration1.85063513
32MP0003632_abnormal_nervous_system1.83463694
33MP0000462_abnormal_digestive_system1.83005762
34MP0002734_abnormal_mechanical_nocicepti1.74718710
35MP0008260_abnormal_autophagy1.67079673
36MP0003635_abnormal_synaptic_transmissio1.66518225
37MP0000579_abnormal_nail_morphology1.60969639
38MP0009046_muscle_twitch1.60696507
39MP0003631_nervous_system_phenotype1.58099185
40MP0009745_abnormal_behavioral_response1.58075354
41MP0004043_abnormal_pH_regulation1.57503213
42MP0003633_abnormal_nervous_system1.46917728
43MP0003123_paternal_imprinting1.45045535
44MP0000747_muscle_weakness1.44002242
45MP0008569_lethality_at_weaning1.42995832
46MP0000604_amyloidosis1.42489375
47MP0000955_abnormal_spinal_cord1.41906324
48MP0000647_abnormal_sebaceous_gland1.33057571
49MP0002098_abnormal_vibrissa_morphology1.33032377
50MP0004134_abnormal_chest_morphology1.32635784
51MP0001664_abnormal_digestion1.27745687
52MP0001970_abnormal_pain_threshold1.27000913
53MP0005551_abnormal_eye_electrophysiolog1.25924242
54* MP0002882_abnormal_neuron_morphology1.25447623
55MP0005623_abnormal_meninges_morphology1.24270685
56MP0003075_altered_response_to1.23528324
57MP0002572_abnormal_emotion/affect_behav1.23248178
58MP0009379_abnormal_foot_pigmentation1.22079343
59MP0002822_catalepsy1.21830510
60MP0002063_abnormal_learning/memory/cond1.21218053
61MP0001440_abnormal_grooming_behavior1.19869941
62* MP0002066_abnormal_motor_capabilities/c1.18213137
63MP0003183_abnormal_peptide_metabolism1.17421504
64MP0008874_decreased_physiological_sensi1.16475764
65MP0005646_abnormal_pituitary_gland1.15759249
66MP0002067_abnormal_sensory_capabilities1.11716571
67MP0004264_abnormal_extraembryonic_tissu1.11697994
68MP0001963_abnormal_hearing_physiology1.11578563
69MP0001346_abnormal_lacrimal_gland1.09746902
70MP0001765_abnormal_ion_homeostasis1.08793842
71MP0003195_calcinosis1.06918691
72MP0004924_abnormal_behavior1.05773153
73MP0005386_behavior/neurological_phenoty1.05773153
74MP0002733_abnormal_thermal_nociception1.05770457
75MP0003806_abnormal_nucleotide_metabolis1.05544887
76MP0001299_abnormal_eye_distance/1.05220459
77MP0000762_abnormal_tongue_morphology1.05086666
78MP0002796_impaired_skin_barrier1.04877644
79MP0002089_abnormal_postnatal_growth/wei1.04093469
80MP0002752_abnormal_somatic_nervous1.02812850
81MP0001851_eye_inflammation0.99842591
82MP0001188_hyperpigmentation0.99626515
83MP0009840_abnormal_foam_cell0.99474824
84MP0000467_abnormal_esophagus_morphology0.98239107
85MP0001177_atelectasis0.96558652
86MP0004147_increased_porphyrin_level0.95251520
87MP0005408_hypopigmentation0.95153174
88MP0005166_decreased_susceptibility_to0.94889965
89MP0002909_abnormal_adrenal_gland0.93900399
90MP0004145_abnormal_muscle_electrophysio0.91938805
91MP0003787_abnormal_imprinting0.90412604
92MP0001984_abnormal_olfaction0.89127340
93MP0008872_abnormal_physiological_respon0.88608853
94MP0004858_abnormal_nervous_system0.88480865
95MP0001968_abnormal_touch/_nociception0.88281335
96MP0003191_abnormal_cellular_cholesterol0.86467471
97MP0003705_abnormal_hypodermis_morpholog0.85306365
98MP0000003_abnormal_adipose_tissue0.85250931
99MP0004019_abnormal_vitamin_homeostasis0.82656424
100MP0005195_abnormal_posterior_eye0.81569628
101MP0005058_abnormal_lysosome_morphology0.80835193
102MP0000566_synostosis0.79917716
103MP0001666_abnormal_nutrient_absorption0.78736844
104MP0000749_muscle_degeneration0.77940857
105MP0002139_abnormal_hepatobiliary_system0.77106104
106MP0008875_abnormal_xenobiotic_pharmacok0.75557588
107MP0003866_abnormal_defecation0.74123787
108MP0000678_abnormal_parathyroid_gland0.73240635
109MP0001661_extended_life_span0.73078989
110MP0008438_abnormal_cutaneous_collagen0.72373318
111MP0002152_abnormal_brain_morphology0.72126510
112MP0001348_abnormal_lacrimal_gland0.72074566
113MP0004036_abnormal_muscle_relaxation0.69847165
114MP0003937_abnormal_limbs/digits/tail_de0.68808521
115MP0000537_abnormal_urethra_morphology0.68249903
116MP0002736_abnormal_nociception_after0.67679263
117MP0001849_ear_inflammation0.67158645
118MP0000377_abnormal_hair_follicle0.66832466
119MP0003938_abnormal_ear_development0.66499567
120MP0005535_abnormal_body_temperature0.66222923
121MP0005670_abnormal_white_adipose0.65428577
122MP0010771_integument_phenotype0.63107830
123MP0003656_abnormal_erythrocyte_physiolo0.62135417
124MP0000639_abnormal_adrenal_gland0.62003068
125MP0000026_abnormal_inner_ear0.61046293
126MP0001501_abnormal_sleep_pattern0.60791434
127MP0005501_abnormal_skin_physiology0.60765988
128MP0001502_abnormal_circadian_rhythm0.60687829
129MP0004185_abnormal_adipocyte_glucose0.60545662
130MP0002735_abnormal_chemical_nociception0.60183945
131MP0002295_abnormal_pulmonary_circulatio0.58484341
132MP0003453_abnormal_keratinocyte_physiol0.57632413
133MP0002557_abnormal_social/conspecific_i0.56888725
134MP0004811_abnormal_neuron_physiology0.56809974

Predicted human phenotypes

RankGene SetZ-score
1Degeneration of the lateral corticospinal tracts (HP:0002314)6.66334741
2Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)6.66334741
3Neurofibrillary tangles (HP:0002185)6.37965028
4Peripheral hypomyelination (HP:0007182)5.47312311
5Abnormality of the corticospinal tract (HP:0002492)4.99906607
6Cerebral hypomyelination (HP:0006808)4.86037236
7Cerebral inclusion bodies (HP:0100314)4.63074590
8Onion bulb formation (HP:0003383)4.62837467
9Parakeratosis (HP:0001036)4.49615784
10Insidious onset (HP:0003587)4.39641752
11Termporal pattern (HP:0011008)4.39641752
12Sensory axonal neuropathy (HP:0003390)4.23354039
13Focal motor seizures (HP:0011153)4.14777903
14Segmental peripheral demyelination/remyelination (HP:0003481)4.05430733
15Abnormal auditory evoked potentials (HP:0006958)4.05167329
16Supranuclear gaze palsy (HP:0000605)3.95701949
17Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.79055460
18* Ankle clonus (HP:0011448)3.75189783
19Focal seizures (HP:0007359)3.57589123
20Spastic gait (HP:0002064)3.56614460
21Epileptic encephalopathy (HP:0200134)3.50784582
22Alacrima (HP:0000522)3.47853864
23Obstructive sleep apnea (HP:0002870)3.47166852
24Diplopia (HP:0000651)3.45680738
25Abnormality of binocular vision (HP:0011514)3.45680738
26Intention tremor (HP:0002080)3.36661508
27Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.34475720
28Pili torti (HP:0003777)3.24903846
29Myokymia (HP:0002411)3.19037233
30Febrile seizures (HP:0002373)3.15131583
31Visual hallucinations (HP:0002367)3.12968301
32Slow saccadic eye movements (HP:0000514)3.02738197
33CNS hypomyelination (HP:0003429)2.96636616
34Retinal dysplasia (HP:0007973)2.90036233
35Upper limb amyotrophy (HP:0009129)2.86752369
36Distal upper limb amyotrophy (HP:0007149)2.86752369
37Clumsiness (HP:0002312)2.82801037
38Foot dorsiflexor weakness (HP:0009027)2.82708505
39Morphological abnormality of the inner ear (HP:0011390)2.75853290
40Axonal loss (HP:0003447)2.75543104
41Spastic paraparesis (HP:0002313)2.74685374
42Decreased lacrimation (HP:0000633)2.74096867
43Scanning speech (HP:0002168)2.71637483
44Atonic seizures (HP:0010819)2.69690667
45* Dysmetria (HP:0001310)2.69520240
46Congenital ichthyosiform erythroderma (HP:0007431)2.65904384
47Hyperactive renin-angiotensin system (HP:0000841)2.65041749
48Action tremor (HP:0002345)2.64164173
49Metabolic alkalosis (HP:0200114)2.64131268
50Postural instability (HP:0002172)2.63300570
51Abnormal eating behavior (HP:0100738)2.61115243
52Tetraplegia (HP:0002445)2.57735062
53Abnormality of the foot musculature (HP:0001436)2.57649394
54Rigidity (HP:0002063)2.57349220
55Torticollis (HP:0000473)2.56595965
56Stridor (HP:0010307)2.55836149
57Annular pancreas (HP:0001734)2.55505088
58Insomnia (HP:0100785)2.55269528
59Increased serum pyruvate (HP:0003542)2.54810822
60Abnormality of glycolysis (HP:0004366)2.54810822
61Muscle fiber splitting (HP:0003555)2.54568698
62Abnormality of renin-angiotensin system (HP:0000847)2.53291717
63Lower limb amyotrophy (HP:0007210)2.51922908
64Hyperparathyroidism (HP:0000843)2.49922763
65Decreased motor nerve conduction velocity (HP:0003431)2.45270144
66Generalized tonic-clonic seizures (HP:0002069)2.43647742
67* Leukodystrophy (HP:0002415)2.39728457
68Hypoplasia of the iris (HP:0007676)2.39148600
69Absent septum pellucidum (HP:0001331)2.38594404
70White forelock (HP:0002211)2.37336792
71Bronchomalacia (HP:0002780)2.36579248
72Increased circulating renin level (HP:0000848)2.35522393
73Pheochromocytoma (HP:0002666)2.34881682
74Hypoplastic pelvis (HP:0008839)2.34372128
75Autoamputation (HP:0001218)2.34220655
76Depression (HP:0000716)2.33205706
77Peripheral demyelination (HP:0011096)2.33148451
78Apathy (HP:0000741)2.31827769
79Anteriorly placed anus (HP:0001545)2.30426022
80Hammertoe (HP:0001765)2.29643987
81Patchy hypopigmentation of hair (HP:0011365)2.29378117
82Urinary bladder sphincter dysfunction (HP:0002839)2.29002780
83Poor speech (HP:0002465)2.27945478
84Hyperaldosteronism (HP:0000859)2.27676831
85Thickened helices (HP:0000391)2.27454932
86Split foot (HP:0001839)2.26974390
87Mutism (HP:0002300)2.25452271
88Coronal craniosynostosis (HP:0004440)2.24862600
89Lower limb muscle weakness (HP:0007340)2.23489011
90Hypokalemic alkalosis (HP:0001949)2.22237510
91Rapidly progressive (HP:0003678)2.21836727
92Ventricular fibrillation (HP:0001663)2.21102294
93Cerebral hemorrhage (HP:0001342)2.20716774
94Truncal ataxia (HP:0002078)2.20398977
95Bundle branch block (HP:0011710)2.17314419
96Paraparesis (HP:0002385)2.16099480
97Premature skin wrinkling (HP:0100678)2.15794440
98Akinesia (HP:0002304)2.15554610
99Hyporeflexia of lower limbs (HP:0002600)2.15262474
100Megalencephaly (HP:0001355)2.13043814
101Distal sensory impairment (HP:0002936)2.11729416
102Focal dystonia (HP:0004373)2.11400380
103Aplasia involving bones of the upper limbs (HP:0009823)2.11335364
104Aplasia of the phalanges of the hand (HP:0009802)2.11335364
105Aplasia involving bones of the extremities (HP:0009825)2.11335364
106Diminished motivation (HP:0000745)2.09276280
107Gowers sign (HP:0003391)2.08478545
108Hypomagnesemia (HP:0002917)2.05930788
109Delusions (HP:0000746)2.05478571
110Ulnar claw (HP:0001178)2.03297679
111Sleep apnea (HP:0010535)2.02896396
112Hand muscle atrophy (HP:0009130)2.01980612
113Renal salt wasting (HP:0000127)2.01586802
114Amelogenesis imperfecta (HP:0000705)2.01150440
115Craniofacial dystonia (HP:0012179)2.00790971
116Partial agenesis of the corpus callosum (HP:0001338)2.00383305
117Diminished movement (HP:0002374)2.00027963
118Status epilepticus (HP:0002133)1.99070711
119Bradykinesia (HP:0002067)1.98415622
120Polar cataract (HP:0010696)1.97902286
121Papilledema (HP:0001085)1.97405937
122Dysdiadochokinesis (HP:0002075)1.97339400
123Abnormality of the phalanges of the 2nd finger (HP:0009541)1.95429605
124Abnormality of the septum pellucidum (HP:0007375)1.94433782
125Abnormality of the middle phalanges of the toes (HP:0010183)1.94414950
126Distal lower limb amyotrophy (HP:0008944)1.94048572
127Progressive cerebellar ataxia (HP:0002073)1.93744705
128Esophageal atresia (HP:0002032)1.93575473
129Morphological abnormality of the pyramidal tract (HP:0002062)1.93395609
130Abnormality of aromatic amino acid family metabolism (HP:0004338)1.93350163
131Choreoathetosis (HP:0001266)1.92233709
132Abnormal hair laboratory examination (HP:0003328)1.91600294
133Hyperacusis (HP:0010780)1.91015911
134Neuroendocrine neoplasm (HP:0100634)1.90751588
135Anxiety (HP:0000739)1.88534021
136Limb dystonia (HP:0002451)1.88182792
137Impaired vibration sensation in the lower limbs (HP:0002166)1.88058897
138Hepatosplenomegaly (HP:0001433)1.86896121
139Bowel incontinence (HP:0002607)1.86002173
140Erythroderma (HP:0001019)1.85794011
141Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.84255192
142Absence seizures (HP:0002121)1.83833701
143Overriding aorta (HP:0002623)1.83458083
144Abnormality of the salivary glands (HP:0010286)1.83141903
145Steppage gait (HP:0003376)1.80503881
146Infantile muscular hypotonia (HP:0008947)1.79978528
147Neuronal loss in central nervous system (HP:0002529)1.76751736
148Cupped ear (HP:0000378)1.74591318
149Abnormality of saccadic eye movements (HP:0000570)1.73891733
150Abnormal large intestine physiology (HP:0012700)1.73848550
151Hypophosphatemic rickets (HP:0004912)1.73462261
152Diaphragmatic weakness (HP:0009113)1.72511344
153Methylmalonic acidemia (HP:0002912)1.72069048
154Difficulty running (HP:0009046)1.69010075
155Anomalous pulmonary venous return (HP:0010772)1.68382808
156Partial duplication of thumb phalanx (HP:0009944)1.67735831
157Choroideremia (HP:0001139)1.64476404
158Humeroradial synostosis (HP:0003041)1.64151531

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK396.27210652
2OXSR14.28081731
3EPHB13.88859820
4EPHA23.66592151
5MST1R3.47699431
6LMTK23.34937686
7MAPKAPK53.15023333
8NTRK33.04418788
9PKN12.90184409
10WNK42.75835421
11RIPK12.63384752
12LIMK12.38832908
13DAPK22.36620277
14BCR2.36309158
15PBK2.25092916
16SIK12.23247504
17MET2.22234195
18CDK192.16314422
19WNK12.08904928
20FGFR22.06809663
21UHMK11.93073674
22TESK21.85429723
23CAMKK11.76832640
24PNCK1.67956968
25CAMK2B1.67259102
26NTRK11.64992565
27MINK11.59016838
28TRIB31.58694175
29ROCK21.57129818
30CSNK1G31.52409381
31SGK4941.52194732
32SGK2231.52194732
33CSNK1A1L1.48893135
34NEK61.47196921
35CLK11.35306051
36CAMK2D1.34493054
37PAK61.33307061
38PRKG21.32050864
39RIPK41.24653735
40FGR1.24576301
41LATS21.22504472
42ICK1.22085726
43CSNK1G11.18867190
44CASK1.18667996
45CSNK1G21.15931864
46PRPF4B1.15474213
47DAPK11.15253115
48ERN11.13769330
49TYRO31.12065700
50CAMK2G1.11017439
51DYRK21.08256842
52TNIK1.08145442
53EPHA41.07889095
54GRK51.05473450
55MARK21.04383752
56MARK11.01212537
57SMG10.99969847
58PTK20.91734868
59PRKD10.91542061
60PHKG10.88958026
61PHKG20.88958026
62ALK0.88786891
63PRKD30.87543339
64CDK140.86476495
65CAMK2A0.86449965
66MST40.86331040
67STK380.84195683
68PAK30.84095966
69CAMK10.83576706
70CDK50.83471607
71KSR20.81109544
72MAPK150.80501031
73CDK150.79629462
74MUSK0.76050966
75PRKCQ0.74193261
76CDK180.73637728
77PDPK10.73317590
78MAP3K110.73075374
79MAP3K10.72138643
80BRSK10.71989403
81CDK11A0.70585591
82IRAK30.69990379
83TRPM70.68113574
84MAP3K120.67521156
85PRKCE0.65700764
86PRKCI0.65534886
87MAP2K20.64458332
88ILK0.62414504
89SGK30.62374205
90PIK3CA0.59531987
91ERBB40.59223355
92MAPK120.57249806
93FYN0.56012878
94IRAK20.55332092
95FGFR40.55115463
96SGK10.53945276
97NTRK20.53684130
98TNK20.52476828
99GSK3A0.51031893
100DAPK30.50870736
101RPS6KA50.50806095
102ERBB20.50225662
103BMPR20.50165828
104CAMK1G0.50148683
105SCYL20.49344891
106PRKCZ0.49177559
107MAP3K20.48805306
108DMPK0.48479549
109PRKG10.47897861
110MAP3K130.47381278
111PLK20.47078650
112CSNK1D0.46705161
113CSNK1A10.46256679
114PRKCG0.46208290
115PINK10.45215900
116PAK10.44988679
117MAPK130.43353514
118BRAF0.43339371
119STK110.42993237
120MAP2K60.42644873
121PDK10.42023942
122ARAF0.41271022
123PRKACB0.40666288
124RPS6KA30.40359441
125GRK70.40189783
126PDK20.40023211
127PRKCH0.39938706
128TESK10.39814589
129SGK20.39343288
130OBSCN0.39070208
131PTK60.38596581
132DDR20.38492838
133SIK20.38104890
134MAP3K90.35732683
135ADRBK20.34313720
136PDGFRB0.28953858
137PRKACA0.28943644
138HIPK20.28618753
139MKNK10.28164943
140CSNK1E0.27981726
141BMX0.27892432
142MAPK100.27349566
143MAPK70.25710589
144PTK2B0.24988706
145BMPR1B0.24226914
146SRC0.22728232

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009005.60987341
2Steroid biosynthesis_Homo sapiens_hsa001004.76503514
3Fatty acid elongation_Homo sapiens_hsa000624.65605329
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.56853370
5Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049643.09855546
6Ether lipid metabolism_Homo sapiens_hsa005653.07391062
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.79525967
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.60016867
9Long-term potentiation_Homo sapiens_hsa047202.43012930
10Sulfur metabolism_Homo sapiens_hsa009202.34116357
11Nitrogen metabolism_Homo sapiens_hsa009102.11790803
12Insulin secretion_Homo sapiens_hsa049112.06666115
13Vitamin B6 metabolism_Homo sapiens_hsa007501.91961649
14Linoleic acid metabolism_Homo sapiens_hsa005911.81855743
15Histidine metabolism_Homo sapiens_hsa003401.78558334
16Sphingolipid metabolism_Homo sapiens_hsa006001.76838451
17Cyanoamino acid metabolism_Homo sapiens_hsa004601.71756200
18Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.71277033
19alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.70370188
20Bile secretion_Homo sapiens_hsa049761.64736082
21Axon guidance_Homo sapiens_hsa043601.57590900
22Aldosterone synthesis and secretion_Homo sapiens_hsa049251.56418947
23Butanoate metabolism_Homo sapiens_hsa006501.54031622
24beta-Alanine metabolism_Homo sapiens_hsa004101.52288920
25Arginine biosynthesis_Homo sapiens_hsa002201.42383047
26Oxidative phosphorylation_Homo sapiens_hsa001901.33634759
27Phosphatidylinositol signaling system_Homo sapiens_hsa040701.29127487
28Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.26729525
29GABAergic synapse_Homo sapiens_hsa047271.21948385
30Protein export_Homo sapiens_hsa030601.19227432
31Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.18653321
32Glutamatergic synapse_Homo sapiens_hsa047241.18231613
33GnRH signaling pathway_Homo sapiens_hsa049121.16330458
34Serotonergic synapse_Homo sapiens_hsa047261.11046126
35Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.10925957
36Estrogen signaling pathway_Homo sapiens_hsa049151.09985478
37Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.05953508
38Tight junction_Homo sapiens_hsa045301.03453427
39Renal cell carcinoma_Homo sapiens_hsa052111.03352556
40Phenylalanine metabolism_Homo sapiens_hsa003601.03212697
41Arginine and proline metabolism_Homo sapiens_hsa003301.01033897
42Thyroid hormone synthesis_Homo sapiens_hsa049181.00443333
43SNARE interactions in vesicular transport_Homo sapiens_hsa041300.99387919
44Parkinsons disease_Homo sapiens_hsa050120.99082681
45Long-term depression_Homo sapiens_hsa047300.98763388
46Alzheimers disease_Homo sapiens_hsa050100.97786086
47Carbohydrate digestion and absorption_Homo sapiens_hsa049730.95262885
482-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.94420775
49Cocaine addiction_Homo sapiens_hsa050300.92477967
50Inositol phosphate metabolism_Homo sapiens_hsa005620.92059692
51Calcium signaling pathway_Homo sapiens_hsa040200.91842232
52Oxytocin signaling pathway_Homo sapiens_hsa049210.91733138
53Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.91251607
54Sphingolipid signaling pathway_Homo sapiens_hsa040710.90165818
55Morphine addiction_Homo sapiens_hsa050320.89780712
56Fructose and mannose metabolism_Homo sapiens_hsa000510.87256438
57Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.86399275
58Glycerophospholipid metabolism_Homo sapiens_hsa005640.85178023
59Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.84464543
60Gastric acid secretion_Homo sapiens_hsa049710.84371412
61Glioma_Homo sapiens_hsa052140.81445923
62Collecting duct acid secretion_Homo sapiens_hsa049660.80016701
63Arachidonic acid metabolism_Homo sapiens_hsa005900.79484276
64Fatty acid metabolism_Homo sapiens_hsa012120.79360675
65Propanoate metabolism_Homo sapiens_hsa006400.77790664
66Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.77471575
67Mineral absorption_Homo sapiens_hsa049780.77268120
68Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.77251863
69Vibrio cholerae infection_Homo sapiens_hsa051100.74832408
70Melanogenesis_Homo sapiens_hsa049160.74600622
71Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.74222449
72Endocytosis_Homo sapiens_hsa041440.73468942
73Salivary secretion_Homo sapiens_hsa049700.72465174
74Circadian entrainment_Homo sapiens_hsa047130.72269550
75Vascular smooth muscle contraction_Homo sapiens_hsa042700.70900933
76Ovarian steroidogenesis_Homo sapiens_hsa049130.69890241
77Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.68987752
78cGMP-PKG signaling pathway_Homo sapiens_hsa040220.67323214
79Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.66758659
80Dorso-ventral axis formation_Homo sapiens_hsa043200.66142476
81VEGF signaling pathway_Homo sapiens_hsa043700.65683086
82Pancreatic secretion_Homo sapiens_hsa049720.65439699
83Ras signaling pathway_Homo sapiens_hsa040140.63918020
84ABC transporters_Homo sapiens_hsa020100.63690133
85Glutathione metabolism_Homo sapiens_hsa004800.63250104
86Phospholipase D signaling pathway_Homo sapiens_hsa040720.62709320
87Cardiac muscle contraction_Homo sapiens_hsa042600.62531894
88Lysosome_Homo sapiens_hsa041420.60394966
89Dopaminergic synapse_Homo sapiens_hsa047280.58841318
90Rap1 signaling pathway_Homo sapiens_hsa040150.57665825
91Phototransduction_Homo sapiens_hsa047440.56728240
92Vitamin digestion and absorption_Homo sapiens_hsa049770.56644962
93Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.56212487
94Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.55636978
95Synaptic vesicle cycle_Homo sapiens_hsa047210.55103506
96Neurotrophin signaling pathway_Homo sapiens_hsa047220.54630706
97Steroid hormone biosynthesis_Homo sapiens_hsa001400.54451277
98Glucagon signaling pathway_Homo sapiens_hsa049220.53804023
99Thyroid hormone signaling pathway_Homo sapiens_hsa049190.53712097
100Renin secretion_Homo sapiens_hsa049240.53086379
101Gap junction_Homo sapiens_hsa045400.52579743
102ErbB signaling pathway_Homo sapiens_hsa040120.50659120
103Cholinergic synapse_Homo sapiens_hsa047250.50126931
104Fatty acid biosynthesis_Homo sapiens_hsa000610.48759065
105Insulin signaling pathway_Homo sapiens_hsa049100.47806922
106Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.47356936
107Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.46622021
108AMPK signaling pathway_Homo sapiens_hsa041520.44839261
109Hedgehog signaling pathway_Homo sapiens_hsa043400.43494551
110Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.43253547
111Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.43078290
112Peroxisome_Homo sapiens_hsa041460.42758776
113Folate biosynthesis_Homo sapiens_hsa007900.42446639
114Autoimmune thyroid disease_Homo sapiens_hsa053200.42025637
115Nicotine addiction_Homo sapiens_hsa050330.41206274
116Galactose metabolism_Homo sapiens_hsa000520.39882619
117Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.39615631
118Rheumatoid arthritis_Homo sapiens_hsa053230.38804911
119Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.38692128
120Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.38580200
121Phagosome_Homo sapiens_hsa041450.37471675
122Oocyte meiosis_Homo sapiens_hsa041140.35904075
123Leukocyte transendothelial migration_Homo sapiens_hsa046700.35809761
124Amphetamine addiction_Homo sapiens_hsa050310.35742450
125Choline metabolism in cancer_Homo sapiens_hsa052310.34407864
126PPAR signaling pathway_Homo sapiens_hsa033200.34274989
127Metabolic pathways_Homo sapiens_hsa011000.33818459
128Central carbon metabolism in cancer_Homo sapiens_hsa052300.33396444
129Pentose and glucuronate interconversions_Homo sapiens_hsa000400.33353509
130Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.32702923
131cAMP signaling pathway_Homo sapiens_hsa040240.32399512
132Chemical carcinogenesis_Homo sapiens_hsa052040.32366378
133Regulation of actin cytoskeleton_Homo sapiens_hsa048100.32170865
134Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.32015331
135Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.31725612
136Pyruvate metabolism_Homo sapiens_hsa006200.31722723
137Olfactory transduction_Homo sapiens_hsa047400.31580593
138Retinol metabolism_Homo sapiens_hsa008300.31394943
139MAPK signaling pathway_Homo sapiens_hsa040100.31077608
140Taste transduction_Homo sapiens_hsa047420.30498073
141Prion diseases_Homo sapiens_hsa050200.29923370
142Huntingtons disease_Homo sapiens_hsa050160.29450668
143ECM-receptor interaction_Homo sapiens_hsa045120.29015597
144Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.28854459
145Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.28275705

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