FAAH

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that is responsible for the hydrolysis of a number of primary and secondary fatty acid amides, including the neuromodulatory compounds anandamide and oleamide. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)7.05571112
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.05571112
3L-phenylalanine metabolic process (GO:0006558)6.64864578
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.64864578
5aromatic amino acid family catabolic process (GO:0009074)6.24446739
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.66877913
7tryptophan catabolic process (GO:0006569)5.58518425
8indole-containing compound catabolic process (GO:0042436)5.58518425
9indolalkylamine catabolic process (GO:0046218)5.58518425
10bile acid biosynthetic process (GO:0006699)5.46515573
11kynurenine metabolic process (GO:0070189)5.36760995
12tryptophan metabolic process (GO:0006568)5.24093574
13high-density lipoprotein particle remodeling (GO:0034375)5.06979819
14glyoxylate metabolic process (GO:0046487)5.04676867
15urea cycle (GO:0000050)4.96045148
16urea metabolic process (GO:0019627)4.96045148
17alpha-linolenic acid metabolic process (GO:0036109)4.82328558
18bile acid metabolic process (GO:0008206)4.67813485
19cysteine metabolic process (GO:0006534)4.65593627
20regulation of fibrinolysis (GO:0051917)4.61261886
21negative regulation of fibrinolysis (GO:0051918)4.57700020
22nitrogen cycle metabolic process (GO:0071941)4.52574984
23sulfur amino acid catabolic process (GO:0000098)4.49762585
24aromatic amino acid family metabolic process (GO:0009072)4.49681323
25regulation of cholesterol esterification (GO:0010872)4.46903701
26peptidyl-glutamic acid carboxylation (GO:0017187)4.42916530
27protein carboxylation (GO:0018214)4.42916530
28complement activation, alternative pathway (GO:0006957)4.40417785
29regulation of protein activation cascade (GO:2000257)4.39333006
30reverse cholesterol transport (GO:0043691)4.39312363
31phospholipid efflux (GO:0033700)4.30049489
32serine family amino acid catabolic process (GO:0009071)4.29646823
33plasma lipoprotein particle remodeling (GO:0034369)4.25986335
34protein-lipid complex remodeling (GO:0034368)4.25986335
35macromolecular complex remodeling (GO:0034367)4.25986335
36fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.25833959
37regulation of triglyceride catabolic process (GO:0010896)4.24360612
38tyrosine metabolic process (GO:0006570)4.24163294
39negative regulation of sterol transport (GO:0032372)4.16247687
40negative regulation of cholesterol transport (GO:0032375)4.16247687
41acylglycerol homeostasis (GO:0055090)4.14861959
42triglyceride homeostasis (GO:0070328)4.14861959
43cellular ketone body metabolic process (GO:0046950)4.13789040
44glutamate metabolic process (GO:0006536)4.12641830
45alpha-amino acid catabolic process (GO:1901606)4.10014811
46mannose metabolic process (GO:0006013)4.08580421
47regulation of complement activation (GO:0030449)4.06390612
48drug catabolic process (GO:0042737)4.06298670
49coenzyme catabolic process (GO:0009109)4.04812189
50homocysteine metabolic process (GO:0050667)4.02199613
51indolalkylamine metabolic process (GO:0006586)4.00317104
52epoxygenase P450 pathway (GO:0019373)3.98243869
53cholesterol efflux (GO:0033344)3.96954916
54amino-acid betaine metabolic process (GO:0006577)3.96662684
55amine catabolic process (GO:0009310)3.93455893
56cellular biogenic amine catabolic process (GO:0042402)3.93455893
57peptidyl-tyrosine autophosphorylation (GO:0038083)3.93171048
58bile acid and bile salt transport (GO:0015721)3.92270206
59dicarboxylic acid biosynthetic process (GO:0043650)3.86509225
60cellular glucuronidation (GO:0052695)3.85062492
61synaptic vesicle exocytosis (GO:0016079)3.84608412
62lysine catabolic process (GO:0006554)3.84230735
63lysine metabolic process (GO:0006553)3.84230735
64imidazole-containing compound metabolic process (GO:0052803)3.83709785
65cellular amino acid catabolic process (GO:0009063)3.78140213
66positive regulation of cellular amine metabolic process (GO:0033240)3.75127354
67regulation of bile acid biosynthetic process (GO:0070857)3.73511680
68cellular modified amino acid catabolic process (GO:0042219)3.72556101
69benzene-containing compound metabolic process (GO:0042537)3.71928551
70positive regulation of synapse maturation (GO:0090129)3.68506181
71glutamate secretion (GO:0014047)3.62168781
72plasma lipoprotein particle assembly (GO:0034377)3.61754880
73NADH metabolic process (GO:0006734)3.60103780
74plasma lipoprotein particle clearance (GO:0034381)3.56967683
75ketone body metabolic process (GO:1902224)3.56282353
76negative regulation of lipase activity (GO:0060192)3.54980957
77exogenous drug catabolic process (GO:0042738)3.54349617
78ethanol oxidation (GO:0006069)3.53260707
79short-chain fatty acid metabolic process (GO:0046459)3.52022638
80low-density lipoprotein particle remodeling (GO:0034374)3.50930211
81uronic acid metabolic process (GO:0006063)3.48814826
82glucuronate metabolic process (GO:0019585)3.48814826
83flavonoid metabolic process (GO:0009812)3.45155928
84positive regulation of lipoprotein lipase activity (GO:0051006)3.44427513
85positive regulation of triglyceride lipase activity (GO:0061365)3.44427513
86aldehyde catabolic process (GO:0046185)3.44274931
87very-low-density lipoprotein particle assembly (GO:0034379)3.42992336
88drug transmembrane transport (GO:0006855)3.42559012
89intestinal cholesterol absorption (GO:0030299)3.39452227
90synaptic vesicle docking involved in exocytosis (GO:0016081)3.39082835
91regulation of cholesterol homeostasis (GO:2000188)3.37470905
92arginine metabolic process (GO:0006525)3.37018069
93serine family amino acid metabolic process (GO:0009069)3.36587892
94cytolysis (GO:0019835)3.34106008
95cofactor catabolic process (GO:0051187)3.33192002
96glutathione biosynthetic process (GO:0006750)3.32828633
97cholesterol homeostasis (GO:0042632)3.30680163
98regulation of cholesterol metabolic process (GO:0090181)3.29121501
99* carboxylic acid catabolic process (GO:0046395)3.27435119
100* organic acid catabolic process (GO:0016054)3.27435119
101fibrinolysis (GO:0042730)3.25798754
102glycine metabolic process (GO:0006544)3.25374221
103complement activation, classical pathway (GO:0006958)3.25260302
104sterol homeostasis (GO:0055092)3.25245348
105very long-chain fatty acid metabolic process (GO:0000038)3.24139719
106plasma lipoprotein particle organization (GO:0071827)3.23177346
107protein-lipid complex assembly (GO:0065005)3.22338924
108positive regulation of lipid catabolic process (GO:0050996)3.21162761
109blood coagulation, intrinsic pathway (GO:0007597)3.20558664
110indole-containing compound metabolic process (GO:0042430)3.20035669
111neurotransmitter secretion (GO:0007269)3.17249132
112phospholipid homeostasis (GO:0055091)3.17232586
113regulation of ARF protein signal transduction (GO:0032012)3.14552670
114nonribosomal peptide biosynthetic process (GO:0019184)3.07234731
115ethanol metabolic process (GO:0006067)3.05986562
116synaptic vesicle maturation (GO:0016188)3.03752147
117positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.01706448
118neurotransmitter catabolic process (GO:0042135)3.00516323
119fructose metabolic process (GO:0006000)2.96680412
120amyloid precursor protein catabolic process (GO:0042987)2.92272738
121GDP-mannose metabolic process (GO:0019673)2.90785320
122peptide biosynthetic process (GO:0043043)2.88142834
123sodium ion export (GO:0071436)2.84169853
124drug metabolic process (GO:0017144)2.83655520
125regulation of synapse maturation (GO:0090128)2.79663342
126regulation of cholesterol biosynthetic process (GO:0045540)2.78897981
127regulation of short-term neuronal synaptic plasticity (GO:0048172)2.77898349
128amyloid precursor protein metabolic process (GO:0042982)2.74402814
129angiotensin maturation (GO:0002003)2.74262086
130alkaloid metabolic process (GO:0009820)2.68678535
131regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.66853136
132biotin metabolic process (GO:0006768)2.65714880
133regulation of neurotransmitter levels (GO:0001505)2.63997813
134positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.63865238
135gamma-aminobutyric acid transport (GO:0015812)2.63497462
136negative regulation of cell size (GO:0045792)2.61162988
137neurotransmitter biosynthetic process (GO:0042136)2.60565552
138cerebellar granule cell differentiation (GO:0021707)2.59490909
139proline metabolic process (GO:0006560)2.59262401
140regulation of synaptic vesicle exocytosis (GO:2000300)2.58696256
141myelin maintenance (GO:0043217)2.55528108
142cell-cell junction maintenance (GO:0045217)2.51023584
143creatine metabolic process (GO:0006600)2.50900431
144phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.46054455
145regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.44792050
146regulation of hydrogen peroxide metabolic process (GO:0010310)2.43104588
147diacylglycerol metabolic process (GO:0046339)2.43090999
148sodium ion homeostasis (GO:0055078)2.40970281
149cellular potassium ion homeostasis (GO:0030007)2.39116854
150phenylpropanoid metabolic process (GO:0009698)2.37884219
151quaternary ammonium group transport (GO:0015697)2.36005892
152phospholipid scrambling (GO:0017121)2.33852785
153regulation of ARF GTPase activity (GO:0032312)2.33061042
154cytoskeletal anchoring at plasma membrane (GO:0007016)2.33046298
155multicellular organismal water homeostasis (GO:0050891)2.32699075
156neurotransmitter transport (GO:0006836)2.32062209
157neuronal ion channel clustering (GO:0045161)2.31037362
158positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.29949501
159dendritic spine organization (GO:0097061)2.28525879
160maintenance of gastrointestinal epithelium (GO:0030277)2.26680311
161* monocarboxylic acid catabolic process (GO:0072329)2.24707524
162* fatty acid catabolic process (GO:0009062)2.24280426
163fatty acid beta-oxidation (GO:0006635)2.23094339
164negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.21877522
165amide biosynthetic process (GO:0043604)2.20611394
166positive regulation of triglyceride metabolic process (GO:0090208)2.20072890
167sperm capacitation (GO:0048240)2.19165433
168actin filament polymerization (GO:0030041)2.18252844
169carnitine transport (GO:0015879)2.16750038
170amino-acid betaine transport (GO:0015838)2.16750038
171actin filament capping (GO:0051693)2.15551759
172omega-hydroxylase P450 pathway (GO:0097267)2.14907306
173cell junction maintenance (GO:0034331)2.13995811
174axon ensheathment in central nervous system (GO:0032291)2.13952350

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.27267423
2RXR_22158963_ChIP-Seq_LIVER_Mouse6.04091717
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse5.03465461
4EGR1_23403033_ChIP-Seq_LIVER_Mouse4.96057412
5LXR_22158963_ChIP-Seq_LIVER_Mouse4.80155716
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.16481626
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.24220742
8* NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.18796689
9TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.99240753
10* LXR_22292898_ChIP-Seq_THP-1_Human2.96583907
11CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.54032441
12EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.41836684
13CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.35914450
14PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.31518214
15* RACK7_27058665_Chip-Seq_MCF-7_Human2.20056796
16VDR_21846776_ChIP-Seq_THP-1_Human2.13744323
17KDM2B_26808549_Chip-Seq_SUP-B15_Human2.00874915
18TET1_21451524_ChIP-Seq_MESCs_Mouse1.99572566
19* P68_20966046_ChIP-Seq_HELA_Human1.97234370
20SMC4_20622854_ChIP-Seq_HELA_Human1.93985649
21SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.85061436
22GBX2_23144817_ChIP-Seq_PC3_Human1.80017524
23CREB1_26743006_Chip-Seq_LNCaP_Human1.79906865
24KDM2B_26808549_Chip-Seq_K562_Human1.74110774
25EZH2_22144423_ChIP-Seq_EOC_Human1.71913610
26* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.71210345
27KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.67592802
28SA1_27219007_Chip-Seq_ERYTHROID_Human1.65623126
29ESR1_21235772_ChIP-Seq_MCF-7_Human1.64778145
30KDM2B_26808549_Chip-Seq_DND41_Human1.63917583
31ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.62719013
32TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.61007502
33BP1_19119308_ChIP-ChIP_Hs578T_Human1.59476398
34CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.58254329
35BCL6_27268052_Chip-Seq_Bcells_Human1.57414861
36ZNF263_19887448_ChIP-Seq_K562_Human1.56508461
37TCF7_22412390_ChIP-Seq_EML_Mouse1.55638366
38* BCOR_27268052_Chip-Seq_Bcells_Human1.54200953
39FOXA2_19822575_ChIP-Seq_HepG2_Human1.47739303
40ZFP281_18757296_ChIP-ChIP_E14_Mouse1.44782679
41RUNX1_27514584_Chip-Seq_MCF-7_Human1.44657860
42SRY_22984422_ChIP-ChIP_TESTIS_Rat1.44308993
43THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.43976463
44ELF1_20517297_ChIP-Seq_JURKAT_Human1.40016161
45TAF15_26573619_Chip-Seq_HEK293_Human1.39881486
46* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.39295511
47HTT_18923047_ChIP-ChIP_STHdh_Human1.39262858
48ELK3_25401928_ChIP-Seq_HUVEC_Human1.36881604
49* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.36683824
50* SA1_27219007_Chip-Seq_Bcells_Human1.36481757
51NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.32135419
52PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.31559280
53TP63_22573176_ChIP-Seq_HFKS_Human1.28788996
54TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.28076443
55* PHF8_20622854_ChIP-Seq_HELA_Human1.25201541
56E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.24172710
57SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.23311117
58* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.23260742
59* TET1_21490601_ChIP-Seq_MESCs_Mouse1.23002137
60VDR_24763502_ChIP-Seq_THP-1_Human1.22526381
61* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.22210365
62E2F1_20622854_ChIP-Seq_HELA_Human1.21955063
63GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.21750674
64GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.20903941
65DROSHA_22980978_ChIP-Seq_HELA_Human1.20790175
66GATA1_19941827_ChIP-Seq_MEL_Mouse1.19888157
67REST_21632747_ChIP-Seq_MESCs_Mouse1.19637688
68CDX2_20551321_ChIP-Seq_CACO-2_Human1.18086367
69OCT4_19829295_ChIP-Seq_ESCs_Human1.17912121
70* CTCF_20526341_ChIP-Seq_ESCs_Human1.17318025
71IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.17145497
72MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.15692805
73UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.13775603
74SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.13762187
75NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.11884986
76* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.11587323
77RARG_19884340_ChIP-ChIP_MEFs_Mouse1.10626250
78TP63_17297297_ChIP-ChIP_HaCaT_Human1.10307293
79HNF4A_19822575_ChIP-Seq_HepG2_Human1.09826883
80RARB_24833708_ChIP-Seq_LIVER_Mouse1.09637202
81CTCF_21964334_ChIP-Seq_BJAB-B_Human1.08927265
82ESR1_20079471_ChIP-ChIP_T-47D_Human1.08581111
83KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.05088089
84RARA_24833708_ChIP-Seq_LIVER_Mouse1.04317469
85CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.04304397
86HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.03791406
87JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.03150438
88* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.02785257
89CTCF_26484167_Chip-Seq_Bcells_Mouse1.02535300
90REST_18959480_ChIP-ChIP_MESCs_Mouse1.01137499
91ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.00731067
92TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99562560
93SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.99153375
94IKZF1_21737484_ChIP-ChIP_HCT116_Human0.98133332
95ETS1_21867929_ChIP-Seq_TH2_Mouse0.97296062
96MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.96901615
97PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96470076
98GATA1_22025678_ChIP-Seq_K562_Human0.95701374
99PU.1_20513432_ChIP-Seq_Bcells_Mouse0.94301777
100ESR1_15608294_ChIP-ChIP_MCF-7_Human0.93963205
101SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.93740059
102CTBP1_25329375_ChIP-Seq_LNCAP_Human0.93248578
103* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.92998411
104KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.92813017
105JARID2_20075857_ChIP-Seq_MESCs_Mouse0.92639740
106CTCF_18555785_ChIP-Seq_MESCs_Mouse0.92016760
107SUZ12_27294783_Chip-Seq_ESCs_Mouse0.91524767
108P63_26484246_Chip-Seq_KERATINOCYTES_Human0.91263084
109* EZH2_27294783_Chip-Seq_ESCs_Mouse0.89503739
110SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.88830951
111JARID2_20064375_ChIP-Seq_MESCs_Mouse0.88782442
112BCAT_22108803_ChIP-Seq_LS180_Human0.88176108
113PIAS1_25552417_ChIP-Seq_VCAP_Human0.88126677
114BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.87608711
115ERG_21242973_ChIP-ChIP_JURKAT_Human0.87084522
116RNF2_18974828_ChIP-Seq_MESCs_Mouse0.86844269
117EZH2_18974828_ChIP-Seq_MESCs_Mouse0.86844269
118DNAJC2_21179169_ChIP-ChIP_NT2_Human0.86694427
119RARB_27405468_Chip-Seq_BRAIN_Mouse0.85346500
120AR_21572438_ChIP-Seq_LNCaP_Human0.85028710
121SMAD4_21799915_ChIP-Seq_A2780_Human0.84182966
122ZFP57_27257070_Chip-Seq_ESCs_Mouse0.82151985
123SOX2_27498859_Chip-Seq_STOMACH_Mouse0.80062181
124SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.79170208
125CTBP2_25329375_ChIP-Seq_LNCAP_Human0.78334767
126ZNF217_24962896_ChIP-Seq_MCF-7_Human0.77964085
127P300_19829295_ChIP-Seq_ESCs_Human0.77713975
128PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.76721597
129AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.76309736
130NRF2_20460467_ChIP-Seq_MEFs_Mouse0.75907055
131NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.75907055
132CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.75869328
133ESR2_21235772_ChIP-Seq_MCF-7_Human0.75587803
134EED_16625203_ChIP-ChIP_MESCs_Mouse0.75225751
135AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.75117441
136GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.74581414
137RXRA_24833708_ChIP-Seq_LIVER_Mouse0.74531332
138BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.72877061
139TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.72408076
140AR_25329375_ChIP-Seq_VCAP_Human0.72198880
141EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.71537627
142* ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.71377457
143STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.71027359
144KDM2B_26808549_Chip-Seq_REH_Human0.69888229
145RUNX1_27457419_Chip-Seq_LIVER_Mouse0.68736640
146MYC_19915707_ChIP-ChIP_AK7_Human0.67141273
147AUTS2_25519132_ChIP-Seq_293T-REX_Human0.67078275
148STAT3_23295773_ChIP-Seq_U87_Human0.66932609
149NR3C1_23031785_ChIP-Seq_PC12_Mouse0.66837534
150PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.65274149
151BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.65243298
152SMAD4_21741376_ChIP-Seq_HESCs_Human0.65102868
153CTCF_27219007_Chip-Seq_Bcells_Human0.64584691
154TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.63357973
155EZH2_27294783_Chip-Seq_NPCs_Mouse0.63357615
156SUZ12_27294783_Chip-Seq_NPCs_Mouse0.63325252
157TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.62254582
158SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.62012330
159OCT4_21477851_ChIP-Seq_ESCs_Mouse0.61980075
160NFE2_27457419_Chip-Seq_LIVER_Mouse0.61777615
161SOX2_21211035_ChIP-Seq_LN229_Gbm0.61617857
162EGR1_19032775_ChIP-ChIP_M12_Human0.61317324
163RAD21_21589869_ChIP-Seq_MESCs_Mouse0.61010438
164SMAD4_21741376_ChIP-Seq_EPCs_Human0.60128455
165SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.59152940
166SMAD3_21741376_ChIP-Seq_EPCs_Human0.58625099
167SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.58416053
168VDR_22108803_ChIP-Seq_LS180_Human0.58367253
169ARNT_22903824_ChIP-Seq_MCF-7_Human0.58191967

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.45069230
2MP0005360_urolithiasis7.06193404
3MP0005085_abnormal_gallbladder_physiolo5.85501782
4MP0005365_abnormal_bile_salt5.53885725
5MP0008875_abnormal_xenobiotic_pharmacok4.84724871
6MP0003252_abnormal_bile_duct3.58288051
7MP0010329_abnormal_lipoprotein_level3.24431080
8MP0003806_abnormal_nucleotide_metabolis3.19043727
9MP0009840_abnormal_foam_cell2.79292719
10MP0003195_calcinosis2.69249342
11MP0001666_abnormal_nutrient_absorption2.65968190
12MP0005332_abnormal_amino_acid2.50494032
13MP0005083_abnormal_biliary_tract2.48369105
14MP0008260_abnormal_autophagy2.30230639
15MP0000678_abnormal_parathyroid_gland2.19980595
16MP0004019_abnormal_vitamin_homeostasis2.11446702
17MP0004858_abnormal_nervous_system2.10698437
18MP0005058_abnormal_lysosome_morphology2.04817129
19MP0003191_abnormal_cellular_cholesterol2.01302172
20MP0002118_abnormal_lipid_homeostasis1.99061176
21MP0003868_abnormal_feces_composition1.93974194
22MP0003183_abnormal_peptide_metabolism1.90284698
23MP0004859_abnormal_synaptic_plasticity1.87399939
24MP0002138_abnormal_hepatobiliary_system1.85698710
25MP0000609_abnormal_liver_physiology1.85495872
26MP0002249_abnormal_larynx_morphology1.77593206
27MP0003172_abnormal_lysosome_physiology1.71264955
28MP0003329_amyloid_beta_deposits1.69272096
29MP0005423_abnormal_somatic_nervous1.60034725
30MP0000604_amyloidosis1.53226890
31MP0001873_stomach_inflammation1.52345183
32MP0001764_abnormal_homeostasis1.50307247
33MP0005584_abnormal_enzyme/coenzyme_acti1.49875524
34MP0005451_abnormal_body_composition1.48256854
35MP0005319_abnormal_enzyme/_coenzyme1.43598454
36MP0004264_abnormal_extraembryonic_tissu1.43362107
37MP0002876_abnormal_thyroid_physiology1.41640745
38MP0003880_abnormal_central_pattern1.39234001
39MP0005645_abnormal_hypothalamus_physiol1.36564991
40MP0008569_lethality_at_weaning1.34787431
41MP0001664_abnormal_digestion1.34156634
42MP0000566_synostosis1.34058666
43MP0000681_abnormal_thyroid_gland1.33931690
44MP0005666_abnormal_adipose_tissue1.32510373
45MP0003866_abnormal_defecation1.31806639
46MP0002734_abnormal_mechanical_nocicepti1.28675919
47MP0001986_abnormal_taste_sensitivity1.21908458
48* MP0002735_abnormal_chemical_nociception1.18428960
49MP0005409_darkened_coat_color1.18214074
50MP0003123_paternal_imprinting1.16773606
51MP0009643_abnormal_urine_homeostasis1.16633444
52MP0009697_abnormal_copulation1.14349106
53MP0005636_abnormal_mineral_homeostasis1.12521341
54MP0004782_abnormal_surfactant_physiolog1.11140815
55MP0004147_increased_porphyrin_level1.06341257
56MP0003635_abnormal_synaptic_transmissio1.04957696
57* MP0009745_abnormal_behavioral_response1.03633840
58MP0005375_adipose_tissue_phenotype1.01523225
59* MP0005535_abnormal_body_temperature0.96506389
60MP0002557_abnormal_social/conspecific_i0.94686564
61MP0008961_abnormal_basal_metabolism0.94566917
62MP0003690_abnormal_glial_cell0.93273385
63MP0009764_decreased_sensitivity_to0.93150923
64MP0002234_abnormal_pharynx_morphology0.92103624
65MP0002064_seizures0.92048986
66MP0002063_abnormal_learning/memory/cond0.91658741
67MP0005647_abnormal_sex_gland0.91104133
68MP0008872_abnormal_physiological_respon0.90655942
69MP0000462_abnormal_digestive_system0.90486057
70MP0003656_abnormal_erythrocyte_physiolo0.89965105
71* MP0001970_abnormal_pain_threshold0.89472510
72MP0004381_abnormal_hair_follicle0.88406411
73MP0009765_abnormal_xenobiotic_induced0.88129765
74MP0002078_abnormal_glucose_homeostasis0.88010438
75MP0010155_abnormal_intestine_physiology0.85805716
76MP0004270_analgesia0.85657122
77MP0004043_abnormal_pH_regulation0.84784804
78MP0009642_abnormal_blood_homeostasis0.83720763
79MP0003011_delayed_dark_adaptation0.83610057
80MP0008874_decreased_physiological_sensi0.82491373
81MP0001905_abnormal_dopamine_level0.81881535
82MP0001501_abnormal_sleep_pattern0.81661975
83MP0001765_abnormal_ion_homeostasis0.81317304
84* MP0002733_abnormal_thermal_nociception0.79324059
85MP0004947_skin_inflammation0.79100269
86MP0005084_abnormal_gallbladder_morpholo0.79094304
87MP0000598_abnormal_liver_morphology0.78359487
88MP0002572_abnormal_emotion/affect_behav0.77444852
89MP0003634_abnormal_glial_cell0.76969410
90MP0002098_abnormal_vibrissa_morphology0.76609535
91MP0004185_abnormal_adipocyte_glucose0.76499735
92MP0000003_abnormal_adipose_tissue0.75464766
93MP0009763_increased_sensitivity_to0.75395408
94MP0008469_abnormal_protein_level0.74601521
95MP0003075_altered_response_to0.71760304
96MP0002272_abnormal_nervous_system0.71218210
97* MP0002066_abnormal_motor_capabilities/c0.71200330
98MP0005167_abnormal_blood-brain_barrier0.71018380
99MP0000013_abnormal_adipose_tissue0.69897624
100MP0003633_abnormal_nervous_system0.69686886
101MP0005448_abnormal_energy_balance0.69600251
102MP0009780_abnormal_chondrocyte_physiolo0.69435344
103MP0002254_reproductive_system_inflammat0.69318614
104MP0010234_abnormal_vibrissa_follicle0.69189145
105MP0003879_abnormal_hair_cell0.68416114
106MP0005646_abnormal_pituitary_gland0.65078018
107MP0005334_abnormal_fat_pad0.64357008
108MP0001984_abnormal_olfaction0.62931030
109MP0002971_abnormal_brown_adipose0.61763691
110MP0001486_abnormal_startle_reflex0.61638018
111MP0001968_abnormal_touch/_nociception0.61474196
112MP0006036_abnormal_mitochondrial_physio0.60597597
113MP0001440_abnormal_grooming_behavior0.58955775
114MP0000639_abnormal_adrenal_gland0.57583605
115MP0005166_decreased_susceptibility_to0.56526454
116MP0003186_abnormal_redox_activity0.56446083
117MP0003953_abnormal_hormone_level0.56361648
118MP0005376_homeostasis/metabolism_phenot0.56262186
119MP0001661_extended_life_span0.56145358
120MP0002736_abnormal_nociception_after0.56140960
121MP0003631_nervous_system_phenotype0.54588674
122MP0002796_impaired_skin_barrier0.54314956
123MP0005408_hypopigmentation0.54250488
124MP0000920_abnormal_myelination0.53546611
125MP0005220_abnormal_exocrine_pancreas0.52950809
126* MP0002069_abnormal_eating/drinking_beha0.52383351
127MP0006276_abnormal_autonomic_nervous0.51452983
128MP0005670_abnormal_white_adipose0.51385342
129MP0003638_abnormal_response/metabolism_0.50827858
130MP0001502_abnormal_circadian_rhythm0.50790695
131MP0002928_abnormal_bile_duct0.50741072
132MP0004142_abnormal_muscle_tone0.49899457
133MP0004885_abnormal_endolymph0.49646364
134MP0001756_abnormal_urination0.47579188
135MP0006082_CNS_inflammation0.47563128
136MP0006035_abnormal_mitochondrial_morpho0.47559524
137MP0005551_abnormal_eye_electrophysiolog0.47444000
138MP0002229_neurodegeneration0.46045174
139MP0002136_abnormal_kidney_physiology0.43331352
140MP0000230_abnormal_systemic_arterial0.41891351
141MP0002909_abnormal_adrenal_gland0.41126334

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.89200832
2Intrahepatic cholestasis (HP:0001406)6.49750557
3Deep venous thrombosis (HP:0002625)6.27359092
4Prolonged partial thromboplastin time (HP:0003645)6.00462860
5Hypobetalipoproteinemia (HP:0003563)5.97115165
6Abnormality of monocarboxylic acid metabolism (HP:0010996)5.69674393
7Xanthomatosis (HP:0000991)5.52877379
8Hyperlipoproteinemia (HP:0010980)5.12055095
9Ankle clonus (HP:0011448)4.57602923
10Complement deficiency (HP:0004431)4.43840854
11Hypolipoproteinemia (HP:0010981)4.09733939
12Myokymia (HP:0002411)4.07147044
13Joint hemorrhage (HP:0005261)4.06861601
14Epidermoid cyst (HP:0200040)4.00297177
15Ketosis (HP:0001946)3.96259720
16Conjugated hyperbilirubinemia (HP:0002908)3.94366186
17Hyperammonemia (HP:0001987)3.92250872
18Fat malabsorption (HP:0002630)3.90247370
19Hyperglycinemia (HP:0002154)3.84592359
20Abnormality of glutamine family amino acid metabolism (HP:0010902)3.83881658
21Abnormality of the common coagulation pathway (HP:0010990)3.83799206
22Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.74796063
23Abnormality of aspartate family amino acid metabolism (HP:0010899)3.71257025
24Abnormality of methionine metabolism (HP:0010901)3.69435880
25Abnormality of sulfur amino acid metabolism (HP:0004339)3.68736154
26Stridor (HP:0010307)3.47332690
27Hyperglycinuria (HP:0003108)3.46958435
28Abnormality of glycine metabolism (HP:0010895)3.44290946
29Abnormality of serine family amino acid metabolism (HP:0010894)3.44290946
30Obstructive sleep apnea (HP:0002870)3.43052534
31Hypoalphalipoproteinemia (HP:0003233)3.23982193
32J-shaped sella turcica (HP:0002680)3.17896217
33Hypoglycemic coma (HP:0001325)3.16682504
34Spontaneous abortion (HP:0005268)3.15906677
35Hypercholesterolemia (HP:0003124)3.15391509
36Abnormality of the intrinsic pathway (HP:0010989)3.10160142
37Hyperactive renin-angiotensin system (HP:0000841)3.07897254
38Hyperbilirubinemia (HP:0002904)3.02939614
39Abnormality of complement system (HP:0005339)2.97866183
40Papilledema (HP:0001085)2.93648518
41Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.93103860
42Ketoacidosis (HP:0001993)2.92624138
43Delayed CNS myelination (HP:0002188)2.88518239
44Steatorrhea (HP:0002570)2.83784578
45Abnormality of pyrimidine metabolism (HP:0004353)2.82993406
46Abnormality of fatty-acid metabolism (HP:0004359)2.77029367
47Acanthocytosis (HP:0001927)2.71970372
48Flat acetabular roof (HP:0003180)2.71090947
49Hyperventilation (HP:0002883)2.69392976
50Metabolic acidosis (HP:0001942)2.69152792
51Decreased circulating renin level (HP:0003351)2.63465116
52Abnormality of nucleobase metabolism (HP:0010932)2.62682381
53Growth hormone excess (HP:0000845)2.61880137
54Gout (HP:0001997)2.58481231
55Abnormality of serum amino acid levels (HP:0003112)2.56327452
56Amelogenesis imperfecta (HP:0000705)2.55286863
57Vascular calcification (HP:0004934)2.55085836
58Abnormality of purine metabolism (HP:0004352)2.52526869
59Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.45212909
60Abnormal gallbladder physiology (HP:0012438)2.44879199
61Cholecystitis (HP:0001082)2.44879199
62Hepatocellular carcinoma (HP:0001402)2.44508364
63Hypochromic microcytic anemia (HP:0004840)2.42529815
64Skin nodule (HP:0200036)2.38568444
65Hypoglycemic seizures (HP:0002173)2.36864554
66Malnutrition (HP:0004395)2.36160993
67Akinesia (HP:0002304)2.35650307
68Spastic gait (HP:0002064)2.33100134
69Irritability (HP:0000737)2.31902253
70Status epilepticus (HP:0002133)2.29734944
71Supranuclear gaze palsy (HP:0000605)2.29111864
72Lethargy (HP:0001254)2.29074092
73Pili torti (HP:0003777)2.28398400
74Amyloidosis (HP:0011034)2.28219176
75Axonal loss (HP:0003447)2.26430826
76Mitral stenosis (HP:0001718)2.25684209
77Abnormal gallbladder morphology (HP:0012437)2.25042747
78Sensorimotor neuropathy (HP:0007141)2.23909450
79Increased neuronal autofluorescent lipopigment (HP:0002074)2.23014677
80Widely patent fontanelles and sutures (HP:0004492)2.21869549
81Abnormality of the periventricular white matter (HP:0002518)2.21129003
82Increased cerebral lipofuscin (HP:0011813)2.20642450
83Brushfield spots (HP:0001088)2.20350590
84Cerebral palsy (HP:0100021)2.20154917
85Focal motor seizures (HP:0011153)2.19594419
86Alkalosis (HP:0001948)2.19555875
87Neonatal onset (HP:0003623)2.18251410
88Hydroxyprolinuria (HP:0003080)2.18071456
89Abnormality of proline metabolism (HP:0010907)2.18071456
90Myocardial infarction (HP:0001658)2.17649823
91Confusion (HP:0001289)2.16799774
92Myopathic facies (HP:0002058)2.16681616
93Urinary glycosaminoglycan excretion (HP:0003541)2.16464183
94Mucopolysacchariduria (HP:0008155)2.16464183
95Abnormality of mucopolysaccharide metabolism (HP:0011020)2.16325093
96Abnormality of polysaccharide metabolism (HP:0011012)2.16325093
97Abnormality of glycosaminoglycan metabolism (HP:0004371)2.16325093
98Bulbar palsy (HP:0001283)2.14355808
99Neurofibrillary tangles (HP:0002185)2.13839096
100Intention tremor (HP:0002080)2.13467722
101Ventricular fibrillation (HP:0001663)2.13267015
102Cardiovascular calcification (HP:0011915)2.13068481
103Hypophosphatemic rickets (HP:0004912)2.12305714
104Cerebral edema (HP:0002181)2.08633891
105Dysostosis multiplex (HP:0000943)2.07457246
106Hyperkalemia (HP:0002153)2.07344414
107Visual hallucinations (HP:0002367)2.06787134
108Dicarboxylic aciduria (HP:0003215)2.06721040
109Abnormality of dicarboxylic acid metabolism (HP:0010995)2.06721040
110Abdominal distention (HP:0003270)2.06667540
111Cholelithiasis (HP:0001081)2.06207012
112Rickets (HP:0002748)2.05840654
113Abnormality of renin-angiotensin system (HP:0000847)2.05299582
114Systemic lupus erythematosus (HP:0002725)2.03522495
115Pancreatitis (HP:0001733)2.03490544
116Bundle branch block (HP:0011710)2.03275474
117Bronchomalacia (HP:0002780)2.02966034
118Glomerulonephritis (HP:0000099)2.02773415
119Neuronal loss in central nervous system (HP:0002529)2.02134930
120Diaphragmatic weakness (HP:0009113)2.02132221
121Hyperinsulinemic hypoglycemia (HP:0000825)2.01421573
122Fair hair (HP:0002286)2.00799263
123Germ cell neoplasia (HP:0100728)2.00724579
124Hyperthyroidism (HP:0000836)2.00323841
125Acute hepatic failure (HP:0006554)1.98509155
126Vomiting (HP:0002013)1.98478101
127Late onset (HP:0003584)1.97225676
128Dysmetria (HP:0001310)1.97152115
129Clonus (HP:0002169)1.93840926
130Hypophosphatemia (HP:0002148)1.93392158
131Thin bony cortex (HP:0002753)1.93108094
132Gingival bleeding (HP:0000225)1.92277549
133Peripheral hypomyelination (HP:0007182)1.91730814
134Enlarged kidneys (HP:0000105)1.91357694
135Hyperparathyroidism (HP:0000843)1.91307796
136Cerebral inclusion bodies (HP:0100314)1.91051020
137Broad face (HP:0000283)1.90199284
138Abnormality of the gallbladder (HP:0005264)1.88945106
139Menorrhagia (HP:0000132)1.88864600
140Sleep apnea (HP:0010535)1.87414372
141Opisthotonus (HP:0002179)1.86213754
142Poikilocytosis (HP:0004447)1.86123991
143Epileptic encephalopathy (HP:0200134)1.86014498
144Renal cortical cysts (HP:0000803)1.85021427
145Abnormality of vitamin metabolism (HP:0100508)1.84829264
146Right ventricular cardiomyopathy (HP:0011663)1.84315047
147Symptomatic seizures (HP:0011145)1.81839936
148Deformed sella turcica (HP:0002681)1.81762588
149Prolonged neonatal jaundice (HP:0006579)1.81229078
150Seborrheic dermatitis (HP:0001051)1.80402364
151Generalized aminoaciduria (HP:0002909)1.79384659
152Neoplasm of the heart (HP:0100544)1.77896920
153Double outlet right ventricle (HP:0001719)1.76526858
154Congenital malformation of the right heart (HP:0011723)1.76526858
155Syncope (HP:0001279)1.76355645
156Urinary urgency (HP:0000012)1.76042703
157Postural instability (HP:0002172)1.74968476
158Thrombophlebitis (HP:0004418)1.74760048
159Nuclear cataract (HP:0100018)1.74428033
160Heart block (HP:0012722)1.73978362
161Delayed myelination (HP:0012448)1.73366694
162Lower limb hyperreflexia (HP:0002395)1.73146330
163Abnormal hair laboratory examination (HP:0003328)1.72246308
164Urinary incontinence (HP:0000020)1.72152964
165Recurrent gram-negative bacterial infections (HP:0005420)1.72092662
166Spastic diplegia (HP:0001264)1.72042344
167Death in childhood (HP:0003819)1.71826158
168Exercise-induced myalgia (HP:0003738)1.71508100
169Colitis (HP:0002583)1.71454459
170Hemorrhage of the eye (HP:0011885)1.71276096
171Hyperaldosteronism (HP:0000859)1.70585846
172Visceral angiomatosis (HP:0100761)1.69822849

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.87067905
2EPHA43.73900372
3FGFR43.67101246
4PRKD33.58966136
5BCKDK3.49097875
6NTRK32.74822829
7DAPK22.48783751
8MAP2K42.48549374
9MAP3K132.43189031
10INSRR2.27539697
11SMG12.25993854
12TAOK32.19420142
13SIK12.18709872
14TAOK12.12155097
15RIPK12.08045323
16TESK11.90351131
17EPHA21.81917384
18TNIK1.78407453
19PRKD21.75740533
20ERN11.73753711
21GRK61.70328509
22MAP2K71.69069414
23MAP3K41.68625184
24MAP3K71.67514204
25CAMK1D1.58902780
26MAP3K91.58177892
27MAP3K111.57159264
28EEF2K1.51400079
29CASK1.43691336
30TXK1.41851301
31PKN21.36863601
32JAK11.24238046
33TYK21.22326766
34MAPK151.21840865
35TESK21.21833934
36PRKCQ1.21652414
37MAPK111.16565174
38SIK21.14824753
39RIPK41.13234784
40SGK4941.12357671
41SGK2231.12357671
42KSR21.11316638
43ERBB41.10425618
44MAP3K141.09784126
45FGFR21.08783283
46PINK11.08513848
47MAP3K121.08056403
48UHMK11.06601680
49IRAK31.06020359
50PRKCG1.05683059
51IKBKE1.03725470
52MST1R1.02197619
53DAPK11.02096925
54FRK1.00175453
55OXSR10.98821287
56ITK0.97615291
57JAK20.97298201
58SGK20.96684906
59NME10.95696025
60CAMK2B0.95113721
61CAMK2G0.95032503
62ICK0.94591691
63STK380.94445140
64NTRK20.94078514
65ARAF0.93955771
66MAP3K20.93323194
67RPS6KA20.92926873
68MAP4K10.92019443
69BMPR20.92019085
70FER0.91700300
71SGK30.90857310
72AKT30.90467726
73MINK10.90376463
74LMTK20.89745270
75SCYL20.89593515
76NEK60.88468707
77CAMK1G0.86968361
78PRKCH0.86712438
79FES0.85871638
80PRKCI0.85063765
81PRKCZ0.84932556
82MAP2K20.84924922
83CAMK2A0.84751572
84MAP2K60.84098841
85MAPKAPK30.83742069
86PDK10.82947156
87MAP3K10.82519116
88DYRK1B0.81506533
89EPHA30.80078806
90CAMK10.78811619
91NTRK10.78552153
92MAPK120.78447876
93PTK60.78329428
94TNK20.76523688
95PRKG20.75658787
96MARK20.73891689
97PHKG10.73854611
98PHKG20.73854611
99PDPK10.73716980
100PAK60.72355945
101CDK50.71097894
102MAPK70.70467299
103PAK30.69850042
104WNK40.69756675
105STK390.68857210
106PKN10.66433181
107CAMKK10.66174962
108IRAK20.65781629
109MAP3K60.64870485
110EPHB10.64837382
111FLT30.63768730
112PIM20.63055038
113KSR10.62616814
114PTK2B0.62578291
115PRKAA10.60957920
116PIK3CG0.59805325
117RPS6KL10.59006778
118RPS6KC10.59006778
119FGFR30.59003819
120SIK30.58975872
121TYRO30.58617177
122GRK50.57513829
123KIT0.54707283
124PRPF4B0.52835408
125MARK10.52833034
126ZAP700.52426803
127PRKACG0.52259671
128SYK0.52085459
129PRKD10.52060216
130CSK0.51565556
131RAF10.50787432
132STK110.50395406
133SGK10.49283782
134JAK30.48967556
135PRKCA0.48940433
136MAPKAPK50.48298315
137TBK10.48046105
138MAPK130.46586919
139PRKAA20.46511914
140ERBB20.45850824
141HIPK20.45781517
142PTK20.45580992
143CSNK1G20.45383876
144RET0.45139638
145RPS6KA60.44556387
146CSF1R0.44082460
147MAPK40.43951592
148TAOK20.41823299
149CAMK40.38350465

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.44003662
2Nitrogen metabolism_Homo sapiens_hsa009103.46411926
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.24744565
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.19172529
5Arginine biosynthesis_Homo sapiens_hsa002202.97600913
6Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.60948417
7Tryptophan metabolism_Homo sapiens_hsa003802.57239895
8Complement and coagulation cascades_Homo sapiens_hsa046102.35542503
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.26388122
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.18463908
11Fatty acid degradation_Homo sapiens_hsa000712.17871650
12Butanoate metabolism_Homo sapiens_hsa006502.17649051
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.13532548
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.12348113
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.11192504
16Histidine metabolism_Homo sapiens_hsa003402.05985659
17Peroxisome_Homo sapiens_hsa041461.97940882
18Steroid hormone biosynthesis_Homo sapiens_hsa001401.88320097
19Chemical carcinogenesis_Homo sapiens_hsa052041.82858038
20Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.81693979
21Bile secretion_Homo sapiens_hsa049761.71869360
22Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.66165549
23PPAR signaling pathway_Homo sapiens_hsa033201.63754293
24Propanoate metabolism_Homo sapiens_hsa006401.62481152
25Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.62150396
26beta-Alanine metabolism_Homo sapiens_hsa004101.61187423
27Retinol metabolism_Homo sapiens_hsa008301.59729696
28Fatty acid metabolism_Homo sapiens_hsa012121.56173189
29Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.56009893
30Sulfur metabolism_Homo sapiens_hsa009201.53626150
31Caffeine metabolism_Homo sapiens_hsa002321.53203168
32Other glycan degradation_Homo sapiens_hsa005111.50246131
33Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.47599998
34Drug metabolism - other enzymes_Homo sapiens_hsa009831.47467833
35Phenylalanine metabolism_Homo sapiens_hsa003601.44729774
36Staphylococcus aureus infection_Homo sapiens_hsa051501.43218807
37Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.39050005
38ABC transporters_Homo sapiens_hsa020101.37596653
39Fatty acid elongation_Homo sapiens_hsa000621.35598940
40Maturity onset diabetes of the young_Homo sapiens_hsa049501.32227740
41Tyrosine metabolism_Homo sapiens_hsa003501.28242205
42Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.26899899
43Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.26833527
44Renin-angiotensin system_Homo sapiens_hsa046141.26453636
45Pyruvate metabolism_Homo sapiens_hsa006201.24908407
46Fat digestion and absorption_Homo sapiens_hsa049751.23993162
47Starch and sucrose metabolism_Homo sapiens_hsa005001.20203138
48Steroid biosynthesis_Homo sapiens_hsa001001.14842299
49Selenocompound metabolism_Homo sapiens_hsa004501.13025194
50Cyanoamino acid metabolism_Homo sapiens_hsa004601.08135167
512-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.05832054
52Cysteine and methionine metabolism_Homo sapiens_hsa002700.99371149
53Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.98673504
54Folate biosynthesis_Homo sapiens_hsa007900.96494053
55Arachidonic acid metabolism_Homo sapiens_hsa005900.94671329
56Vitamin digestion and absorption_Homo sapiens_hsa049770.94043478
57Glycosaminoglycan degradation_Homo sapiens_hsa005310.91650514
58Glycerolipid metabolism_Homo sapiens_hsa005610.85051454
59Arginine and proline metabolism_Homo sapiens_hsa003300.84394643
60Cocaine addiction_Homo sapiens_hsa050300.84132623
61Phosphatidylinositol signaling system_Homo sapiens_hsa040700.81147832
62AMPK signaling pathway_Homo sapiens_hsa041520.76969446
63Biosynthesis of amino acids_Homo sapiens_hsa012300.76538836
64Pancreatic secretion_Homo sapiens_hsa049720.73412720
65Carbon metabolism_Homo sapiens_hsa012000.71388687
66Sulfur relay system_Homo sapiens_hsa041220.68716798
67Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.68190622
68GnRH signaling pathway_Homo sapiens_hsa049120.67816580
69Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.67594584
70Vibrio cholerae infection_Homo sapiens_hsa051100.66599137
71Dopaminergic synapse_Homo sapiens_hsa047280.66339559
72Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.66102002
73Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.65794464
74Lysine degradation_Homo sapiens_hsa003100.64572798
75Serotonergic synapse_Homo sapiens_hsa047260.63836560
76Notch signaling pathway_Homo sapiens_hsa043300.63305793
77Insulin signaling pathway_Homo sapiens_hsa049100.61328898
78Nicotine addiction_Homo sapiens_hsa050330.59640340
79Vitamin B6 metabolism_Homo sapiens_hsa007500.57935738
80Estrogen signaling pathway_Homo sapiens_hsa049150.56883558
81Choline metabolism in cancer_Homo sapiens_hsa052310.56713133
82Inositol phosphate metabolism_Homo sapiens_hsa005620.54553243
83Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.54070221
84Cholinergic synapse_Homo sapiens_hsa047250.52487307
85Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.47184942
86VEGF signaling pathway_Homo sapiens_hsa043700.47170639
87Collecting duct acid secretion_Homo sapiens_hsa049660.45726392
88Fatty acid biosynthesis_Homo sapiens_hsa000610.44822850
89Glycerophospholipid metabolism_Homo sapiens_hsa005640.40463785
90Prion diseases_Homo sapiens_hsa050200.39839118
91Glutathione metabolism_Homo sapiens_hsa004800.39706005
92Metabolic pathways_Homo sapiens_hsa011000.37800065
93GABAergic synapse_Homo sapiens_hsa047270.37046590
94Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.32415244
95Glutamatergic synapse_Homo sapiens_hsa047240.30757460
96Insulin secretion_Homo sapiens_hsa049110.29650765
97Amphetamine addiction_Homo sapiens_hsa050310.28566217
98alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.27974725
99Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.24834629
100Linoleic acid metabolism_Homo sapiens_hsa005910.24457612
101* Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.24045611
102Long-term potentiation_Homo sapiens_hsa047200.23262968
103Aldosterone synthesis and secretion_Homo sapiens_hsa049250.21041097
104Glucagon signaling pathway_Homo sapiens_hsa049220.20769252
105Pentose phosphate pathway_Homo sapiens_hsa000300.20424421
106Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.19978421
107Circadian entrainment_Homo sapiens_hsa047130.19369912
108Salivary secretion_Homo sapiens_hsa049700.16413406
109Synaptic vesicle cycle_Homo sapiens_hsa047210.15933518
110Carbohydrate digestion and absorption_Homo sapiens_hsa049730.15203656
111Insulin resistance_Homo sapiens_hsa049310.13325462
112Galactose metabolism_Homo sapiens_hsa000520.12813167
113Morphine addiction_Homo sapiens_hsa050320.12094821
114Adipocytokine signaling pathway_Homo sapiens_hsa049200.11924790
115Thyroid hormone synthesis_Homo sapiens_hsa049180.11773371
116Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.10237375
117Type II diabetes mellitus_Homo sapiens_hsa049300.09506255
118Taste transduction_Homo sapiens_hsa047420.09283157
119Fructose and mannose metabolism_Homo sapiens_hsa000510.08710449
120Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.07210646
121African trypanosomiasis_Homo sapiens_hsa051430.06579980
122Gastric acid secretion_Homo sapiens_hsa049710.04701030
123Renin secretion_Homo sapiens_hsa049240.04496300
124Mineral absorption_Homo sapiens_hsa049780.02952299
125Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.01279834

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