FAAH2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a fatty acid amide hydrolase that shares a conserved protein motif with the amidase signature family of enzymes. The encoded enzyme is able to catalyze the hydrolysis of a broad range of bioactive lipids, including those from the three main classes of fatty acid amides; N-acylethanolamines, fatty acid primary amides and N-acyl amino acids. This enzyme has a preference for monounsaturated acyl chains as a substrate. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1phenylpropanoid metabolic process (GO:0009698)5.29318253
2cellular ketone body metabolic process (GO:0046950)4.91681831
3inositol phosphate catabolic process (GO:0071545)4.69256237
4inositol phosphate dephosphorylation (GO:0046855)4.65835245
5phosphorylated carbohydrate dephosphorylation (GO:0046838)4.65835245
6L-alpha-amino acid transmembrane transport (GO:1902475)4.44845956
7endocrine pancreas development (GO:0031018)4.41814372
8negative regulation of execution phase of apoptosis (GO:1900118)4.32866645
9ketone body metabolic process (GO:1902224)4.26028719
10auditory receptor cell differentiation (GO:0042491)4.25309690
11regulation of protein glycosylation (GO:0060049)4.19153201
12regulation of type B pancreatic cell apoptotic process (GO:2000674)4.08430922
13L-phenylalanine catabolic process (GO:0006559)4.03296301
14erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.03296301
15insulin secretion (GO:0030073)4.01938247
16Golgi to endosome transport (GO:0006895)3.98901938
17water-soluble vitamin biosynthetic process (GO:0042364)3.79278064
18erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.76718536
19L-phenylalanine metabolic process (GO:0006558)3.76718536
20polyol catabolic process (GO:0046174)3.76480356
21lactate metabolic process (GO:0006089)3.73810034
22epithelial cell fate commitment (GO:0072148)3.71830896
23respiratory chain complex IV assembly (GO:0008535)3.57815135
24glycerophospholipid catabolic process (GO:0046475)3.50151354
25regulation of glucokinase activity (GO:0033131)3.42096451
26regulation of hexokinase activity (GO:1903299)3.42096451
27nitric oxide biosynthetic process (GO:0006809)3.39915614
28hair cell differentiation (GO:0035315)3.39230781
29positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003573.37182976
30regulation of regulatory T cell differentiation (GO:0045589)3.35026154
31xenobiotic catabolic process (GO:0042178)3.34885705
32positive regulation of insulin secretion (GO:0032024)3.30834866
33signal peptide processing (GO:0006465)3.26456250
34negative regulation of complement activation (GO:0045916)3.25492341
35zinc ion transmembrane transport (GO:0071577)3.24588275
36protein prenylation (GO:0018342)3.24393587
37prenylation (GO:0097354)3.24393587
38axoneme assembly (GO:0035082)3.22676548
39peptide hormone processing (GO:0016486)3.22675391
40intestinal epithelial cell development (GO:0060576)3.19670218
41glandular epithelial cell differentiation (GO:0002067)3.19081341
42nodal signaling pathway (GO:0038092)3.18970465
43zinc ion homeostasis (GO:0055069)3.07953745
44short-chain fatty acid metabolic process (GO:0046459)3.07369949
45negative regulation of protein activation cascade (GO:2000258)3.01568260
46negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.99436526
47photoreceptor cell maintenance (GO:0045494)2.99185532
48intra-Golgi vesicle-mediated transport (GO:0006891)2.99169392
49positive regulation of actin filament depolymerization (GO:0030836)2.97529848
50positive regulation of peptide hormone secretion (GO:0090277)2.96467814
51protein K11-linked deubiquitination (GO:0035871)2.95875076
52cytochrome complex assembly (GO:0017004)2.95151378
53inner ear receptor cell differentiation (GO:0060113)2.92755613
54epithelial cilium movement (GO:0003351)2.92483153
55macroautophagy (GO:0016236)2.91801095
56positive regulation of glycolytic process (GO:0045821)2.90933055
57keratinocyte development (GO:0003334)2.90335905
58regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.90195612
59C-terminal protein lipidation (GO:0006501)2.89455478
60positive regulation of response to nutrient levels (GO:0032109)2.87506163
61positive regulation of response to extracellular stimulus (GO:0032106)2.87506163
62retinol metabolic process (GO:0042572)2.84161087
63zinc ion transport (GO:0006829)2.84012993
64regulation of vacuole organization (GO:0044088)2.83895304
65positive regulation of peptide secretion (GO:0002793)2.83199246
66positive regulation of macroautophagy (GO:0016239)2.81859947
67sphingomyelin metabolic process (GO:0006684)2.80560795
68mannosylation (GO:0097502)2.78377236
69nonmotile primary cilium assembly (GO:0035058)2.78351137
70protein targeting to Golgi (GO:0000042)2.77909046
71nucleoside diphosphate catabolic process (GO:0009134)2.77863165
72phospholipid dephosphorylation (GO:0046839)2.77518161
73cellular zinc ion homeostasis (GO:0006882)2.77428769
74cilium movement (GO:0003341)2.75312756
75regulation of acrosome reaction (GO:0060046)2.75070492
76peptide hormone secretion (GO:0030072)2.71751159
77establishment of protein localization to Golgi (GO:0072600)2.71362612
78regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.71258072
79positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.71258072
80negative regulation of glycoprotein biosynthetic process (GO:0010561)2.71116417
81glial cell proliferation (GO:0014009)2.70925184
82magnesium ion transport (GO:0015693)2.70460782
83negative regulation of hormone biosynthetic process (GO:0032353)2.70262883
84preassembly of GPI anchor in ER membrane (GO:0016254)2.69562354
85negative regulation of neurological system process (GO:0031645)2.66680464
86peptide secretion (GO:0002790)2.65286293
87C-terminal protein amino acid modification (GO:0018410)2.64804840
88glucosamine-containing compound catabolic process (GO:1901072)2.64528241
89detection of calcium ion (GO:0005513)2.62300671
90negative regulation of humoral immune response (GO:0002921)2.61203414
91positive regulation of histone H3-K4 methylation (GO:0051571)2.60894596
92toxin metabolic process (GO:0009404)2.60689127
93urate metabolic process (GO:0046415)2.60620849
94beta-amyloid metabolic process (GO:0050435)2.59280740
95positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.57346384
96regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.57346384
97glucosamine-containing compound metabolic process (GO:1901071)2.55613157
98negative regulation of hormone metabolic process (GO:0032351)2.54565127
99basic amino acid transport (GO:0015802)2.52574858
100positive regulation of calcium ion import (GO:0090280)2.50839556

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse7.22234715
2SALL1_21062744_ChIP-ChIP_HESCs_Human2.76004264
3POU3F2_20337985_ChIP-ChIP_501MEL_Human2.66305801
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.56090010
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.44314780
6FLI1_27457419_Chip-Seq_LIVER_Mouse2.34904100
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.07253553
8PIAS1_25552417_ChIP-Seq_VCAP_Human1.99368252
9AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.97808234
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.91051691
11ZNF274_21170338_ChIP-Seq_K562_Hela1.85793842
12FUS_26573619_Chip-Seq_HEK293_Human1.83772236
13TAF15_26573619_Chip-Seq_HEK293_Human1.80225497
14ER_23166858_ChIP-Seq_MCF-7_Human1.79796270
15PCGF2_27294783_Chip-Seq_ESCs_Mouse1.75120066
16CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.73794482
17GBX2_23144817_ChIP-Seq_PC3_Human1.70724061
18P300_19829295_ChIP-Seq_ESCs_Human1.69088718
19HTT_18923047_ChIP-ChIP_STHdh_Human1.68791829
20DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.66234557
21FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.64393834
22EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.57427663
23GABP_17652178_ChIP-ChIP_JURKAT_Human1.56674623
24SUZ12_27294783_Chip-Seq_NPCs_Mouse1.56619753
25NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.53053934
26FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.51850907
27RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.49796957
28MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.47823792
29ZNF217_24962896_ChIP-Seq_MCF-7_Human1.46595909
30CTBP2_25329375_ChIP-Seq_LNCAP_Human1.44436935
31BCAT_22108803_ChIP-Seq_LS180_Human1.42365872
32FOXM1_26456572_ChIP-Seq_MCF-7_Human1.40999076
33FOXA1_27270436_Chip-Seq_PROSTATE_Human1.40044981
34FOXA1_25329375_ChIP-Seq_VCAP_Human1.40044981
35FOXA1_25552417_ChIP-Seq_VCAP_Human1.38617141
36HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.38407135
37STAT3_23295773_ChIP-Seq_U87_Human1.38196994
38NFE2_27457419_Chip-Seq_LIVER_Mouse1.37882617
39* ARNT_22903824_ChIP-Seq_MCF-7_Human1.37546042
40CDX2_22108803_ChIP-Seq_LS180_Human1.37063905
41EGR1_23403033_ChIP-Seq_LIVER_Mouse1.36135409
42GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.36082966
43AR_20517297_ChIP-Seq_VCAP_Human1.35894808
44VDR_22108803_ChIP-Seq_LS180_Human1.35573794
45SMAD4_21799915_ChIP-Seq_A2780_Human1.33919997
46AR_25329375_ChIP-Seq_VCAP_Human1.31652812
47EZH2_27294783_Chip-Seq_NPCs_Mouse1.31385926
48PADI4_21655091_ChIP-ChIP_MCF-7_Human1.30944560
49NANOG_18555785_Chip-Seq_ESCs_Mouse1.29925347
50TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.25895588
51ELK1_19687146_ChIP-ChIP_HELA_Human1.25024320
52FOXA1_21572438_ChIP-Seq_LNCaP_Human1.24728352
53PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.24461013
54AHR_22903824_ChIP-Seq_MCF-7_Human1.24113498
55SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23387939
56NOTCH1_21737748_ChIP-Seq_TLL_Human1.22211999
57TP53_22573176_ChIP-Seq_HFKS_Human1.21789142
58SOX2_20726797_ChIP-Seq_SW620_Human1.21329671
59EWS_26573619_Chip-Seq_HEK293_Human1.21212644
60KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.20991118
61IGF1R_20145208_ChIP-Seq_DFB_Human1.20940309
62IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.20461371
63CBP_20019798_ChIP-Seq_JUKART_Human1.20461371
64FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.20214852
65TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.19806409
66TCF4_22108803_ChIP-Seq_LS180_Human1.18303199
67P53_22387025_ChIP-Seq_ESCs_Mouse1.18290725
68PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.18066433
69SUZ12_18555785_Chip-Seq_ESCs_Mouse1.17301463
70SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.17206216
71AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.16748168
72ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.16740030
73TCF4_23295773_ChIP-Seq_U87_Human1.15467354
74STAT3_18555785_Chip-Seq_ESCs_Mouse1.15270701
75EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.14429089
76HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.14393130
77STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.14027172
78NANOG_19829295_ChIP-Seq_ESCs_Human1.13816001
79SOX2_19829295_ChIP-Seq_ESCs_Human1.13816001
80SOX2_18555785_Chip-Seq_ESCs_Mouse1.13496731
81BMI1_23680149_ChIP-Seq_NPCS_Mouse1.13099957
82CTBP1_25329375_ChIP-Seq_LNCAP_Human1.11887345
83CRX_20693478_ChIP-Seq_RETINA_Mouse1.10727693
84CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.09994090
85P300_18555785_Chip-Seq_ESCs_Mouse1.09118765
86VDR_23849224_ChIP-Seq_CD4+_Human1.09098799
87OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09009959
88CMYC_18555785_Chip-Seq_ESCs_Mouse1.08490808
89E2F1_18555785_Chip-Seq_ESCs_Mouse1.07023483
90CDX2_19796622_ChIP-Seq_MESCs_Mouse1.07017734
91NR3C1_21868756_ChIP-Seq_MCF10A_Human1.06586821
92OCT4_18555785_Chip-Seq_ESCs_Mouse1.06104787
93GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.04511128
94PCGF2_27294783_Chip-Seq_NPCs_Mouse1.04304177
95NMYC_18555785_Chip-Seq_ESCs_Mouse1.04042982
96GATA4_25053715_ChIP-Seq_YYC3_Human1.03273328
97EST1_17652178_ChIP-ChIP_JURKAT_Human1.02411495
98FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.01570274
99HOXB7_26014856_ChIP-Seq_BT474_Human1.00084657
100CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.99991895

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005379_endocrine/exocrine_gland_phen4.31509937
2MP0009780_abnormal_chondrocyte_physiolo4.20685207
3MP0002837_dystrophic_cardiac_calcinosis3.93641920
4MP0002163_abnormal_gland_morphology3.55841001
5MP0006072_abnormal_retinal_apoptosis3.30152782
6MP0005645_abnormal_hypothalamus_physiol3.00485835
7MP0010234_abnormal_vibrissa_follicle2.98413143
8MP0003787_abnormal_imprinting2.89850196
9MP0005365_abnormal_bile_salt2.81516723
10MP0003195_calcinosis2.81278325
11MP0002876_abnormal_thyroid_physiology2.60004932
12MP0008877_abnormal_DNA_methylation2.48018740
13MP0005083_abnormal_biliary_tract2.37723643
14MP0002909_abnormal_adrenal_gland2.37326104
15MP0001944_abnormal_pancreas_morphology2.33173037
16MP0002139_abnormal_hepatobiliary_system2.30475131
17MP0002928_abnormal_bile_duct2.29399683
18MP0005220_abnormal_exocrine_pancreas2.28821829
19MP0002693_abnormal_pancreas_physiology2.17934950
20MP0003252_abnormal_bile_duct2.06961581
21MP0005085_abnormal_gallbladder_physiolo2.05285022
22MP0005646_abnormal_pituitary_gland2.01511740
23MP0004043_abnormal_pH_regulation1.92638833
24MP0002277_abnormal_respiratory_mucosa1.88038565
25MP0004019_abnormal_vitamin_homeostasis1.82387308
26MP0000013_abnormal_adipose_tissue1.78302594
27MP0005084_abnormal_gallbladder_morpholo1.71655606
28MP0005253_abnormal_eye_physiology1.69273688
29MP0009697_abnormal_copulation1.67389266
30MP0005332_abnormal_amino_acid1.65556311
31MP0002254_reproductive_system_inflammat1.62143527
32MP0010329_abnormal_lipoprotein_level1.60470114
33MP0010678_abnormal_skin_adnexa1.56162589
34MP0003122_maternal_imprinting1.56016162
35MP0005551_abnormal_eye_electrophysiolog1.53658073
36MP0000427_abnormal_hair_cycle1.50771473
37MP0001756_abnormal_urination1.47901435
38MP0002078_abnormal_glucose_homeostasis1.44758401
39MP0003786_premature_aging1.41687302
40MP0000003_abnormal_adipose_tissue1.41356701
41MP0008057_abnormal_DNA_replication1.40982464
42MP0008872_abnormal_physiological_respon1.40782490
43MP0003943_abnormal_hepatobiliary_system1.38562886
44MP0001984_abnormal_olfaction1.32438617
45MP0001666_abnormal_nutrient_absorption1.24950744
46MP0003183_abnormal_peptide_metabolism1.24434920
47MP0003868_abnormal_feces_composition1.23197480
48MP0008875_abnormal_xenobiotic_pharmacok1.23187508
49MP0009046_muscle_twitch1.20578740
50MP0005636_abnormal_mineral_homeostasis1.19838743
51MP0002138_abnormal_hepatobiliary_system1.19111677
52MP0001765_abnormal_ion_homeostasis1.16332439
53MP0003283_abnormal_digestive_organ1.12402500
54MP0003011_delayed_dark_adaptation1.12231442
55MP0004133_heterotaxia1.08586667
56MP0000383_abnormal_hair_follicle1.07744376
57MP0010386_abnormal_urinary_bladder1.07308490
58MP0003953_abnormal_hormone_level1.06212979
59MP0002638_abnormal_pupillary_reflex1.05455301
60MP0006036_abnormal_mitochondrial_physio1.04210333
61MP0004270_analgesia1.04050094
62MP0005448_abnormal_energy_balance1.02400698
63MP0002166_altered_tumor_susceptibility1.01839856
64MP0002102_abnormal_ear_morphology1.00715960
65MP0003121_genomic_imprinting0.96951733
66MP0001501_abnormal_sleep_pattern0.95635231
67MP0009643_abnormal_urine_homeostasis0.94045530
68MP0003866_abnormal_defecation0.93890620
69MP0002118_abnormal_lipid_homeostasis0.93642116
70MP0002009_preneoplasia0.91302380
71MP0000372_irregular_coat_pigmentation0.89704013
72MP0000631_abnormal_neuroendocrine_gland0.89506907
73MP0000639_abnormal_adrenal_gland0.88556502
74MP0003045_fibrosis0.87893444
75MP0003890_abnormal_embryonic-extraembry0.87313176
76MP0001764_abnormal_homeostasis0.86978871
77MP0005075_abnormal_melanosome_morpholog0.80647976
78MP0001919_abnormal_reproductive_system0.78385726
79MP0002168_other_aberrant_phenotype0.72821618
80MP0004264_abnormal_extraembryonic_tissu0.72433477
81MP0008995_early_reproductive_senescence0.71307743
82MP0004885_abnormal_endolymph0.71126751
83MP0002006_tumorigenesis0.69657140
84MP0003123_paternal_imprinting0.67383623
85MP0000613_abnormal_salivary_gland0.65659597
86MP0002136_abnormal_kidney_physiology0.64919028
87MP0005395_other_phenotype0.64288239
88MP0010352_gastrointestinal_tract_polyps0.61890486
89MP0002229_neurodegeneration0.61025269
90MP0002557_abnormal_social/conspecific_i0.60359507
91MP0003633_abnormal_nervous_system0.59601053
92MP0004924_abnormal_behavior0.59154173
93MP0005386_behavior/neurological_phenoty0.59154173
94MP0000647_abnormal_sebaceous_gland0.58855530
95MP0005408_hypopigmentation0.58410621
96MP0001346_abnormal_lacrimal_gland0.58025816
97MP0009642_abnormal_blood_homeostasis0.57374953
98MP0002090_abnormal_vision0.56757935
99MP0003186_abnormal_redox_activity0.55838348
100MP0001873_stomach_inflammation0.55012327

Predicted human phenotypes

RankGene SetZ-score
1Hypoglycemic seizures (HP:0002173)4.56424651
2Hypoglycemic coma (HP:0001325)4.38779022
3Hyperinsulinemic hypoglycemia (HP:0000825)4.16740394
4Abnormality of aromatic amino acid family metabolism (HP:0004338)3.80113730
5Ketoacidosis (HP:0001993)3.71945737
6Medial flaring of the eyebrow (HP:0010747)3.55548846
7Hyperglycemia (HP:0003074)3.23523961
8Symptomatic seizures (HP:0011145)3.10344652
9Hypokinesia (HP:0002375)3.00627411
10Agitation (HP:0000713)2.95578212
11Hamartoma of the eye (HP:0010568)2.89567592
12Congenital primary aphakia (HP:0007707)2.85524895
13Abnormality of endocrine pancreas physiology (HP:0012093)2.81004408
14Abnormality of the pancreatic islet cells (HP:0006476)2.81004408
15Ketosis (HP:0001946)2.79253289
16Hypothermia (HP:0002045)2.78824223
17Abnormality of vitamin B metabolism (HP:0004340)2.78086949
18Gait imbalance (HP:0002141)2.74166728
19Large for gestational age (HP:0001520)2.74075938
20Abnormality of the renal cortex (HP:0011035)2.67814698
21Late onset (HP:0003584)2.66716189
22Methylmalonic acidemia (HP:0002912)2.64778414
23Pancreatic fibrosis (HP:0100732)2.61060474
24Congenital sensorineural hearing impairment (HP:0008527)2.61052350
25Bronchiectasis (HP:0002110)2.52053772
26Abnormality of vitamin metabolism (HP:0100508)2.48458138
27Nephrogenic diabetes insipidus (HP:0009806)2.46441386
28Pancreatic cysts (HP:0001737)2.43502296
29Rhinitis (HP:0012384)2.39661905
30Insulin-resistant diabetes mellitus (HP:0000831)2.39328028
31Delayed CNS myelination (HP:0002188)2.38865295
32Steatorrhea (HP:0002570)2.36346583
33Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.31344973
34Abnormality of macular pigmentation (HP:0008002)2.26978380
35Methylmalonic aciduria (HP:0012120)2.21496332
36Ependymoma (HP:0002888)2.21267395
37Hypomagnesemia (HP:0002917)2.16687197
38Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.16299731
39EEG with generalized epileptiform discharges (HP:0011198)2.16149149
40Furrowed tongue (HP:0000221)2.15434216
41Genital tract atresia (HP:0001827)2.15064101
42Exocrine pancreatic insufficiency (HP:0001738)2.14553117
43Hypsarrhythmia (HP:0002521)2.14302155
44Conjunctival hamartoma (HP:0100780)2.12591757
45Neuroendocrine neoplasm (HP:0100634)2.12555059
46Diminished movement (HP:0002374)2.12277057
47Tubular atrophy (HP:0000092)2.09804932
48Epileptiform EEG discharges (HP:0011182)2.07327499
49Metaphyseal dysplasia (HP:0100255)2.05797040
50Pancreatic islet-cell hyperplasia (HP:0004510)2.05120972
51Fat malabsorption (HP:0002630)2.04096398
52Renal cortical cysts (HP:0000803)2.03866507
53Nephronophthisis (HP:0000090)2.02745217
54Poor coordination (HP:0002370)2.02185842
553-Methylglutaconic aciduria (HP:0003535)2.01076953
56Villous atrophy (HP:0011473)2.00858771
57Abnormality of small intestinal villus morphology (HP:0011472)2.00858771
58True hermaphroditism (HP:0010459)2.00396979
59Severe visual impairment (HP:0001141)1.99954613
60Pheochromocytoma (HP:0002666)1.99105489
61Chronic bronchitis (HP:0004469)1.98705416
62Decreased circulating renin level (HP:0003351)1.98666891
63Abnormal ciliary motility (HP:0012262)1.98452491
64Abnormal respiratory epithelium morphology (HP:0012253)1.98222004
65Abnormal respiratory motile cilium morphology (HP:0005938)1.98222004
66Prolonged partial thromboplastin time (HP:0003645)1.97221192
67Abnormal respiratory motile cilium physiology (HP:0012261)1.97171627
68Attenuation of retinal blood vessels (HP:0007843)1.96471772
69Vascular calcification (HP:0004934)1.96343837
70Posterior subcapsular cataract (HP:0007787)1.95764563
71Hepatic necrosis (HP:0002605)1.93551710
72Neoplasm of the adrenal gland (HP:0100631)1.92415657
73Abnormality of the renal medulla (HP:0100957)1.91929456
74Vaginal atresia (HP:0000148)1.91365779
75Double outlet right ventricle (HP:0001719)1.88510975
76Congenital malformation of the right heart (HP:0011723)1.88510975
77Unilateral renal agenesis (HP:0000122)1.87974306
78Astrocytoma (HP:0009592)1.87312571
79Abnormality of the astrocytes (HP:0100707)1.87312571
80Xanthomatosis (HP:0000991)1.87238289
81Labial hypoplasia (HP:0000066)1.87112918
82Abnormal pancreas size (HP:0012094)1.86603768
83Intestinal atresia (HP:0011100)1.86405452
84Neonatal respiratory distress (HP:0002643)1.85431654
85Increased CSF protein (HP:0002922)1.83529368
86Abnormality of urine glucose concentration (HP:0011016)1.83163243
87Glycosuria (HP:0003076)1.83163243
88Azoospermia (HP:0000027)1.82977484
89Hypoplastic labia majora (HP:0000059)1.82791497
90Goiter (HP:0000853)1.76628959
91Vacuolated lymphocytes (HP:0001922)1.72339069
92Muscular hypotonia of the trunk (HP:0008936)1.71717965
93Palpitations (HP:0001962)1.71673259
94Bony spicule pigmentary retinopathy (HP:0007737)1.71308771
95Aplasia/hypoplasia of the uterus (HP:0008684)1.70244610
96Gout (HP:0001997)1.69898014
97Menstrual irregularities (HP:0000858)1.67865080
98Abnormality of midbrain morphology (HP:0002418)1.66224412
99Molar tooth sign on MRI (HP:0002419)1.66224412
100Abnormality of the labia majora (HP:0012881)1.66172631

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.91022398
2MST44.20909406
3EIF2AK13.72394803
4WNK33.42118091
5EIF2AK33.35920170
6MAP4K22.95276985
7ERBB32.89284613
8PASK2.43194444
9CASK2.37004711
10BMPR1B2.31187455
11TRIM282.27539962
12LMTK22.19144041
13MAP3K42.16739101
14FGFR22.02971619
15ACVR1B1.94421726
16PAK31.77023476
17FER1.71609490
18BRD41.71343366
19NLK1.67242883
20STK241.66753993
21PRKD31.57039956
22GRK11.55650172
23TXK1.54576688
24INSRR1.47774825
25STK38L1.47215449
26PHKG21.41203363
27PHKG11.41203363
28MAP3K121.36580946
29EPHA31.27485178
30BCR1.23972063
31STK31.22397727
32FGFR31.20315932
33ITK1.19553326
34OXSR11.10069870
35MAP3K91.04618133
36STK391.03478620
37ADRBK20.99775609
38MAP3K20.94200515
39CAMKK20.91451804
40NUAK10.90684155
41PRKCE0.89242517
42NTRK30.85985747
43CSNK1G10.83630657
44MAP2K60.82270634
45SIK30.78766267
46AKT30.78078596
47PAK60.73019906
48PRKAA20.72511228
49YES10.71600250
50RPS6KB20.70942398
51TNK20.69639389
52TRPM70.68366106
53PINK10.67757427
54MAPK130.64959749
55MST1R0.64889210
56CSNK1G30.64194650
57UHMK10.64121015
58MKNK20.61686896
59MAPKAPK30.61388081
60IKBKB0.60556217
61DAPK20.60503552
62TAOK30.57765514
63BMPR20.53456613
64LATS10.53276389
65JAK10.52522417
66IRAK10.51645397
67FGFR40.49809031
68PRKCI0.49705720
69EIF2AK20.49484474
70MAP2K20.48733220
71CSNK1G20.47358961
72WNK40.46811308
73STK100.46652125
74CAMK2D0.43587604
75HIPK20.43573765
76CHUK0.43401216
77TEC0.41398058
78ZAK0.40235914
79PLK20.39917975
80PIK3CA0.38544784
81GRK60.37675570
82PRKAA10.37350971
83BCKDK0.36038011
84BRSK20.36029577
85EPHA20.35693704
86CSNK1A1L0.35168175
87EPHB10.35139703
88CDK30.34466105
89PRKCG0.33907343
90MAPK110.33542741
91PRKCQ0.31261190
92ATM0.30255361
93NEK60.29939811
94IKBKE0.29831363
95PTK2B0.29190546
96TSSK60.28211678
97CSNK1D0.27855924
98PLK30.27549716
99MARK30.25612511
100PRKACA0.24855942

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049505.97830378
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.18295165
3Protein export_Homo sapiens_hsa030603.08787502
4Butanoate metabolism_Homo sapiens_hsa006503.06956645
5Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.40954942
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.20313789
7Sulfur metabolism_Homo sapiens_hsa009202.19722157
8Peroxisome_Homo sapiens_hsa041462.15620976
9Caffeine metabolism_Homo sapiens_hsa002321.94004746
10Fatty acid elongation_Homo sapiens_hsa000621.84780716
11Circadian rhythm_Homo sapiens_hsa047101.84537129
12Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.78420268
13Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.69654877
14Propanoate metabolism_Homo sapiens_hsa006401.69321704
15Sphingolipid metabolism_Homo sapiens_hsa006001.62489767
16Primary bile acid biosynthesis_Homo sapiens_hsa001201.59830326
17Insulin secretion_Homo sapiens_hsa049111.56478272
18Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.54339981
19Pentose and glucuronate interconversions_Homo sapiens_hsa000401.53453761
20Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.50103646
21Vitamin B6 metabolism_Homo sapiens_hsa007501.46167227
22Retinol metabolism_Homo sapiens_hsa008301.43600591
23Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.43210617
24Oxidative phosphorylation_Homo sapiens_hsa001901.39231988
25Chemical carcinogenesis_Homo sapiens_hsa052041.38214298
26Linoleic acid metabolism_Homo sapiens_hsa005911.37851054
27Folate biosynthesis_Homo sapiens_hsa007901.37556555
28Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.37143866
29Phototransduction_Homo sapiens_hsa047441.37083409
30Arginine biosynthesis_Homo sapiens_hsa002201.32218523
31Collecting duct acid secretion_Homo sapiens_hsa049661.30858694
32beta-Alanine metabolism_Homo sapiens_hsa004101.29471091
33Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.28958490
34Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.27194693
35Selenocompound metabolism_Homo sapiens_hsa004501.26757308
36Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.19545807
37Ether lipid metabolism_Homo sapiens_hsa005651.19384088
38ABC transporters_Homo sapiens_hsa020101.18263327
39Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.16846743
40Starch and sucrose metabolism_Homo sapiens_hsa005001.12375826
41Fatty acid biosynthesis_Homo sapiens_hsa000611.11785267
42Type I diabetes mellitus_Homo sapiens_hsa049401.11299948
43Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.05865697
44Steroid hormone biosynthesis_Homo sapiens_hsa001401.03709046
45Glutathione metabolism_Homo sapiens_hsa004801.02458499
46Tryptophan metabolism_Homo sapiens_hsa003801.02125119
47Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.01821939
48Basal transcription factors_Homo sapiens_hsa030220.99407745
49Histidine metabolism_Homo sapiens_hsa003400.94980829
50Regulation of autophagy_Homo sapiens_hsa041400.94252181
51alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.93682447
52Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.93278025
53N-Glycan biosynthesis_Homo sapiens_hsa005100.89994737
54Fatty acid metabolism_Homo sapiens_hsa012120.89827773
55Arachidonic acid metabolism_Homo sapiens_hsa005900.87640298
56Fatty acid degradation_Homo sapiens_hsa000710.85361800
57Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.85230473
58Non-homologous end-joining_Homo sapiens_hsa034500.83239360
59Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.81192365
60Metabolic pathways_Homo sapiens_hsa011000.78170609
61Pancreatic secretion_Homo sapiens_hsa049720.76449537
62Proteasome_Homo sapiens_hsa030500.73063350
63Mineral absorption_Homo sapiens_hsa049780.71705016
64Glucagon signaling pathway_Homo sapiens_hsa049220.70560276
65Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.70527613
66Nitrogen metabolism_Homo sapiens_hsa009100.66384433
67Drug metabolism - other enzymes_Homo sapiens_hsa009830.66294187
68Vibrio cholerae infection_Homo sapiens_hsa051100.62742344
69Glycerolipid metabolism_Homo sapiens_hsa005610.61368216
70RNA degradation_Homo sapiens_hsa030180.60260055
71Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.59890216
72Steroid biosynthesis_Homo sapiens_hsa001000.58301984
73Fat digestion and absorption_Homo sapiens_hsa049750.58255242
74Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.57264624
75Arginine and proline metabolism_Homo sapiens_hsa003300.56937528
76Phenylalanine metabolism_Homo sapiens_hsa003600.56246796
77Complement and coagulation cascades_Homo sapiens_hsa046100.55206766
78Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.55172023
79Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.52325019
80Tyrosine metabolism_Homo sapiens_hsa003500.51022840
81Parkinsons disease_Homo sapiens_hsa050120.49995736
82RNA polymerase_Homo sapiens_hsa030200.49450628
83Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.48830080
84Ovarian steroidogenesis_Homo sapiens_hsa049130.43701728
85Glycerophospholipid metabolism_Homo sapiens_hsa005640.43531378
86Renin secretion_Homo sapiens_hsa049240.42868863
87Cysteine and methionine metabolism_Homo sapiens_hsa002700.42741516
88Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.37832464
89Carbohydrate digestion and absorption_Homo sapiens_hsa049730.36541915
90Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.36208787
91Type II diabetes mellitus_Homo sapiens_hsa049300.35856119
92Serotonergic synapse_Homo sapiens_hsa047260.33472987
93Vitamin digestion and absorption_Homo sapiens_hsa049770.33408588
94Alzheimers disease_Homo sapiens_hsa050100.33333301
95Long-term depression_Homo sapiens_hsa047300.33092155
96Taste transduction_Homo sapiens_hsa047420.29952172
97Purine metabolism_Homo sapiens_hsa002300.29272927
98Bile secretion_Homo sapiens_hsa049760.29033207
99Pyruvate metabolism_Homo sapiens_hsa006200.28950777
100Huntingtons disease_Homo sapiens_hsa050160.27931636

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