FAAHP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1GMP metabolic process (GO:0046037)6.11531833
2detection of light stimulus involved in visual perception (GO:0050908)5.90750901
3detection of light stimulus involved in sensory perception (GO:0050962)5.90750901
4sperm capacitation (GO:0048240)5.88091676
5retinal rod cell development (GO:0046548)5.42534172
6retinal cone cell development (GO:0046549)5.36805447
7protein-chromophore linkage (GO:0018298)5.23069297
8multicellular organism reproduction (GO:0032504)5.12802568
9eye photoreceptor cell development (GO:0042462)4.80914038
10photoreceptor cell development (GO:0042461)4.79218108
11photoreceptor cell maintenance (GO:0045494)4.74036777
12rhodopsin mediated signaling pathway (GO:0016056)4.67471588
13mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.45268365
14regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)4.41356200
15regulation of mitotic spindle checkpoint (GO:1903504)4.41356200
16tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.24163562
17RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.24163562
18peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)4.23828607
19tachykinin receptor signaling pathway (GO:0007217)4.15524349
20calcium ion import (GO:0070509)3.99902272
21mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.96079541
22visual perception (GO:0007601)3.88710749
23ATP synthesis coupled proton transport (GO:0015986)3.86393262
24energy coupled proton transport, down electrochemical gradient (GO:0015985)3.86393262
25regulation of mitochondrial translation (GO:0070129)3.86013856
26sensory perception of light stimulus (GO:0050953)3.84104203
27rRNA modification (GO:0000154)3.69143509
28establishment of protein localization to mitochondrial membrane (GO:0090151)3.69032063
29rRNA methylation (GO:0031167)3.62743445
30respiratory electron transport chain (GO:0022904)3.58070899
31response to pheromone (GO:0019236)3.53593831
32electron transport chain (GO:0022900)3.51911901
33sperm-egg recognition (GO:0035036)3.47832818
34sperm motility (GO:0030317)3.46706330
35reproduction (GO:0000003)3.46160103
36protein complex biogenesis (GO:0070271)3.40007653
37mitochondrial respiratory chain complex assembly (GO:0033108)3.38805331
38regulation of gonadotropin secretion (GO:0032276)3.33958811
39positive regulation of cell cycle checkpoint (GO:1901978)3.32915234
40negative regulation of astrocyte differentiation (GO:0048712)3.28031422
41protein heterotetramerization (GO:0051290)3.25851751
42deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.25451105
43respiratory chain complex IV assembly (GO:0008535)3.19302403
44retinoic acid receptor signaling pathway (GO:0048384)3.15290461
45detection of light stimulus (GO:0009583)3.13319993
46DNA deamination (GO:0045006)3.12367724
47DNA double-strand break processing (GO:0000729)3.11895953
48telomere maintenance via recombination (GO:0000722)3.11259044
49pteridine-containing compound biosynthetic process (GO:0042559)3.11052694
50proteasome assembly (GO:0043248)3.07338068
51cytochrome complex assembly (GO:0017004)3.04084734
52spinal cord association neuron differentiation (GO:0021527)3.02869374
53double-strand break repair via homologous recombination (GO:0000724)3.02312433
54DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.98617776
55recombinational repair (GO:0000725)2.96081360
56regulation of cellular amino acid metabolic process (GO:0006521)2.92384874
57phototransduction (GO:0007602)2.92324534
58signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.91664864
59intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.91664864
60signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.89356235
61signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.89356235
62signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.89356235
63exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.86794351
64nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.86750029
65response to interferon-beta (GO:0035456)2.86712742
66inner mitochondrial membrane organization (GO:0007007)2.81867819
67membrane depolarization during action potential (GO:0086010)2.80757458
68protein targeting to mitochondrion (GO:0006626)2.80535781
69negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.80132949
70single fertilization (GO:0007338)2.78230023
71signal transduction involved in DNA damage checkpoint (GO:0072422)2.75742257
72signal transduction involved in DNA integrity checkpoint (GO:0072401)2.75742257
73ribosomal small subunit assembly (GO:0000028)2.75265788
74cell-cell recognition (GO:0009988)2.74485970
75pseudouridine synthesis (GO:0001522)2.73933450
76ether lipid metabolic process (GO:0046485)2.72370094
77nucleoside salvage (GO:0043174)2.72303283
78signal transduction involved in cell cycle checkpoint (GO:0072395)2.71403695
79negative regulation of reactive oxygen species metabolic process (GO:2000378)2.70649699
80male meiosis I (GO:0007141)2.70084945
81regulation of rhodopsin mediated signaling pathway (GO:0022400)2.68580663
82positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.64390779
83piRNA metabolic process (GO:0034587)2.63924773
84positive regulation of neurotransmitter secretion (GO:0001956)2.61055415
85ubiquinone biosynthetic process (GO:0006744)2.60195045
86mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.59330306
87mitochondrial respiratory chain complex I assembly (GO:0032981)2.59330306
88NADH dehydrogenase complex assembly (GO:0010257)2.59330306
89mannosylation (GO:0097502)2.57884486
90establishment of protein localization to mitochondrion (GO:0072655)2.57408347
91negative regulation of ligase activity (GO:0051352)2.53117293
92negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.53117293
93ATP biosynthetic process (GO:0006754)2.51735493
94RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.51626076
95regulation of mRNA catabolic process (GO:0061013)2.51491938
96mitotic recombination (GO:0006312)2.49924060
97somatic hypermutation of immunoglobulin genes (GO:0016446)2.48037692
98somatic diversification of immune receptors via somatic mutation (GO:0002566)2.48037692
99axoneme assembly (GO:0035082)2.47839968
100DNA methylation involved in gamete generation (GO:0043046)2.46788579

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GABP_17652178_ChIP-ChIP_JURKAT_Human4.21010592
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.13795218
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.81779871
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.50787288
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.94124909
6ETS1_20019798_ChIP-Seq_JURKAT_Human2.92991745
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.84361017
8ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.84080663
9MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.61128686
10VDR_23849224_ChIP-Seq_CD4+_Human2.51003142
11GATA1_22025678_ChIP-Seq_K562_Human2.43774335
12PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.33499093
13E2F7_22180533_ChIP-Seq_HELA_Human2.28955408
14SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.24327863
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.21549013
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.12229592
17FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.10116335
18FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.08284176
19EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human2.06744584
20FOXP3_21729870_ChIP-Seq_TREG_Human2.01565067
21SRF_21415370_ChIP-Seq_HL-1_Mouse1.98207188
22VDR_22108803_ChIP-Seq_LS180_Human1.96209108
23ELK1_19687146_ChIP-ChIP_HELA_Human1.94585054
24STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.86663372
25HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.85800667
26PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.82888241
27ZNF274_21170338_ChIP-Seq_K562_Hela1.80900275
28ETV1_20927104_ChIP-Seq_GIST48_Human1.79298806
29RBPJ_21746931_ChIP-Seq_IB4_Human1.77446354
30CBX2_22325352_ChIP-Seq_293T-Rex_Human1.75289771
31CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.73210687
32YY1_21170310_ChIP-Seq_MESCs_Mouse1.66299012
33PHF8_20622853_ChIP-Seq_HELA_Human1.66020773
34IGF1R_20145208_ChIP-Seq_DFB_Human1.65945760
35GATA6_21074721_ChIP-Seq_CACO-2_Human1.65659186
36CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.63896000
37FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.63145656
38FLI1_27457419_Chip-Seq_LIVER_Mouse1.62495662
39GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.61954487
40POU3F2_20337985_ChIP-ChIP_501MEL_Human1.60095368
41PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.55806641
42E2F4_17652178_ChIP-ChIP_JURKAT_Human1.52734662
43THAP11_20581084_ChIP-Seq_MESCs_Mouse1.50028721
44POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.49079741
45PADI4_21655091_ChIP-ChIP_MCF-7_Human1.47650027
46HNFA_21074721_ChIP-Seq_CACO-2_Human1.45986156
47NFYB_21822215_ChIP-Seq_K562_Human1.45235057
48HOXB4_20404135_ChIP-ChIP_EML_Mouse1.44379824
49SA1_27219007_Chip-Seq_Bcells_Human1.44124165
50TP53_22573176_ChIP-Seq_HFKS_Human1.41643740
51MYC_18940864_ChIP-ChIP_HL60_Human1.39451232
52DCP1A_22483619_ChIP-Seq_HELA_Human1.39228079
53TBL1_22424771_ChIP-Seq_293T_Human1.36058108
54KDM5A_27292631_Chip-Seq_BREAST_Human1.34925399
55MYC_18358816_ChIP-ChIP_MESCs_Mouse1.34559893
56MYC_18555785_ChIP-Seq_MESCs_Mouse1.29734133
57AR_20517297_ChIP-Seq_VCAP_Human1.27127475
58NFYA_21822215_ChIP-Seq_K562_Human1.24263836
59FUS_26573619_Chip-Seq_HEK293_Human1.22253142
60NFE2_27457419_Chip-Seq_LIVER_Mouse1.21171633
61TTF2_22483619_ChIP-Seq_HELA_Human1.21120248
62TAF15_26573619_Chip-Seq_HEK293_Human1.21086173
63HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.20884285
64SUZ12_27294783_Chip-Seq_NPCs_Mouse1.18624873
65GABP_19822575_ChIP-Seq_HepG2_Human1.16153954
66FOXA1_27270436_Chip-Seq_PROSTATE_Human1.15386203
67FOXA1_25329375_ChIP-Seq_VCAP_Human1.15386203
68DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.13256674
69HTT_18923047_ChIP-ChIP_STHdh_Human1.13250373
70MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.13012657
71RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.11452417
72CBP_21632823_ChIP-Seq_H3396_Human1.10028468
73MYC_19829295_ChIP-Seq_ESCs_Human1.09767945
74NCOR_22424771_ChIP-Seq_293T_Human1.09099861
75PCGF2_27294783_Chip-Seq_ESCs_Mouse1.08719834
76TAF2_19829295_ChIP-Seq_ESCs_Human1.08444611
77NANOG_20526341_ChIP-Seq_ESCs_Human1.07502546
78EGR1_23403033_ChIP-Seq_LIVER_Mouse1.07168078
79CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.06990884
80MYC_19030024_ChIP-ChIP_MESCs_Mouse1.04103269
81SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.04093771
82POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.02800091
83EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.00788484
84ER_23166858_ChIP-Seq_MCF-7_Human1.00247403
85ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.99244281
86YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.99192408
87ERG_20517297_ChIP-Seq_VCAP_Human0.97256831
88EWS_26573619_Chip-Seq_HEK293_Human0.91129806
89BCAT_22108803_ChIP-Seq_LS180_Human0.90466215
90IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.90141865
91ELF5_23300383_ChIP-Seq_T47D_Human0.90134165
92CTBP1_25329375_ChIP-Seq_LNCAP_Human0.89919132
93FOXA1_21572438_ChIP-Seq_LNCaP_Human0.88672850
94CTCF_18555785_ChIP-Seq_MESCs_Mouse0.88459439
95FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.87755632
96GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.84566324
97SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.84418811
98GATA3_21878914_ChIP-Seq_MCF-7_Human0.84217425
99EZH2_27294783_Chip-Seq_NPCs_Mouse0.83957435
100XRN2_22483619_ChIP-Seq_HELA_Human0.83907828

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002822_catalepsy8.13658260
2MP0002638_abnormal_pupillary_reflex6.83080132
3MP0005551_abnormal_eye_electrophysiolog4.01198824
4MP0008057_abnormal_DNA_replication3.57427987
5MP0005253_abnormal_eye_physiology3.44973665
6MP0006072_abnormal_retinal_apoptosis2.93010123
7MP0003806_abnormal_nucleotide_metabolis2.56587196
8MP0006035_abnormal_mitochondrial_morpho2.49065751
9MP0003880_abnormal_central_pattern2.47337504
10MP0001986_abnormal_taste_sensitivity2.36900557
11MP0010030_abnormal_orbit_morphology2.02383899
12MP0002234_abnormal_pharynx_morphology1.99936646
13MP0001764_abnormal_homeostasis1.98927127
14MP0008058_abnormal_DNA_repair1.86546167
15MP0005646_abnormal_pituitary_gland1.81767051
16MP0003787_abnormal_imprinting1.78274077
17MP0002229_neurodegeneration1.67557829
18MP0005195_abnormal_posterior_eye1.63059900
19MP0009333_abnormal_splenocyte_physiolog1.62797427
20MP0003646_muscle_fatigue1.59940511
21MP0002102_abnormal_ear_morphology1.57603493
22MP0003786_premature_aging1.54690129
23MP0000372_irregular_coat_pigmentation1.48309332
24MP0002272_abnormal_nervous_system1.47537369
25MP0009046_muscle_twitch1.46820580
26MP0005391_vision/eye_phenotype1.44477353
27MP0009697_abnormal_copulation1.34399956
28MP0002735_abnormal_chemical_nociception1.33641872
29MP0002876_abnormal_thyroid_physiology1.32759825
30MP0005410_abnormal_fertilization1.31978912
31MP0009745_abnormal_behavioral_response1.30788571
32MP0002752_abnormal_somatic_nervous1.30355004
33MP0008877_abnormal_DNA_methylation1.29012576
34MP0000631_abnormal_neuroendocrine_gland1.27967661
35MP0005645_abnormal_hypothalamus_physiol1.27947783
36MP0008995_early_reproductive_senescence1.27618472
37MP0006276_abnormal_autonomic_nervous1.19770234
38MP0001905_abnormal_dopamine_level1.18943500
39MP0006292_abnormal_olfactory_placode1.16946790
40MP0001661_extended_life_span1.15537134
41MP0001984_abnormal_olfaction1.15326218
42MP0001968_abnormal_touch/_nociception1.12459878
43MP0008260_abnormal_autophagy1.12074631
44MP0005377_hearing/vestibular/ear_phenot1.11606372
45MP0003878_abnormal_ear_physiology1.11606372
46MP0005423_abnormal_somatic_nervous1.08730099
47MP0004036_abnormal_muscle_relaxation1.08454661
48MP0004742_abnormal_vestibular_system1.07898867
49MP0006036_abnormal_mitochondrial_physio1.06153833
50MP0001502_abnormal_circadian_rhythm1.04312442
51MP0001929_abnormal_gametogenesis1.03915613
52MP0001542_abnormal_bone_strength1.00969541
53MP0001324_abnormal_eye_pigmentation1.00131168
54MP0001919_abnormal_reproductive_system0.99741179
55MP0008872_abnormal_physiological_respon0.99711147
56MP0004142_abnormal_muscle_tone0.97398013
57MP0003943_abnormal_hepatobiliary_system0.96701382
58MP0008875_abnormal_xenobiotic_pharmacok0.96351543
59MP0010386_abnormal_urinary_bladder0.94846591
60MP0003763_abnormal_thymus_physiology0.94457890
61MP0006138_congestive_heart_failure0.94436750
62MP0004147_increased_porphyrin_level0.91070540
63MP0003011_delayed_dark_adaptation0.88124631
64MP0003698_abnormal_male_reproductive0.87493001
65MP0002160_abnormal_reproductive_system0.87269475
66MP0002163_abnormal_gland_morphology0.86783855
67MP0002882_abnormal_neuron_morphology0.84000950
68MP0003191_abnormal_cellular_cholesterol0.83209084
69MP0000639_abnormal_adrenal_gland0.82502963
70MP0001346_abnormal_lacrimal_gland0.82165621
71MP0001501_abnormal_sleep_pattern0.80052249
72MP0000703_abnormal_thymus_morphology0.80007075
73MP0003567_abnormal_fetal_cardiomyocyte0.79112642
74MP0002067_abnormal_sensory_capabilities0.78303984
75MP0000358_abnormal_cell_content/0.77786964
76MP0000015_abnormal_ear_pigmentation0.74808465
77MP0005389_reproductive_system_phenotype0.73790842
78MP0003638_abnormal_response/metabolism_0.71602283
79MP0002210_abnormal_sex_determination0.66700089
80MP0001486_abnormal_startle_reflex0.66335339
81MP0009780_abnormal_chondrocyte_physiolo0.65572716
82MP0004043_abnormal_pH_regulation0.64685561
83MP0005386_behavior/neurological_phenoty0.63939836
84MP0004924_abnormal_behavior0.63939836
85MP0001529_abnormal_vocalization0.62633187
86MP0003077_abnormal_cell_cycle0.62395081
87MP0002132_abnormal_respiratory_system0.60803703
88MP0004019_abnormal_vitamin_homeostasis0.59178499
89MP0003635_abnormal_synaptic_transmissio0.58751841
90MP0003186_abnormal_redox_activity0.58691346
91MP0003950_abnormal_plasma_membrane0.58607535
92MP0010094_abnormal_chromosome_stability0.58579521
93MP0001873_stomach_inflammation0.58395622
94MP0005075_abnormal_melanosome_morpholog0.54989344
95MP0002184_abnormal_innervation0.54809885
96MP0001835_abnormal_antigen_presentation0.54002772
97MP0003879_abnormal_hair_cell0.51017266
98MP0002557_abnormal_social/conspecific_i0.49600367
99MP0000653_abnormal_sex_gland0.48390934
100MP0008873_increased_physiological_sensi0.48169614

Predicted human phenotypes

RankGene SetZ-score
1Central scotoma (HP:0000603)8.55853191
2Subcapsular cataract (HP:0000523)7.66179773
3Scotoma (HP:0000575)6.86091807
4Constricted visual fields (HP:0001133)6.12887968
5Intestinal atresia (HP:0011100)5.00726957
6Absent rod-and cone-mediated responses on ERG (HP:0007688)4.80362954
7Abnormal rod and cone electroretinograms (HP:0008323)4.72799551
8Abnormality of the phalanges of the 2nd finger (HP:0009541)4.58870841
9Dyschromatopsia (HP:0007641)4.43483487
10Bony spicule pigmentary retinopathy (HP:0007737)4.34955602
11Polar cataract (HP:0010696)4.33131025
12Supernumerary spleens (HP:0009799)4.03384737
13Attenuation of retinal blood vessels (HP:0007843)3.94896024
14Abnormality of macular pigmentation (HP:0008002)3.89394345
15Septo-optic dysplasia (HP:0100842)3.71198938
16Abolished electroretinogram (ERG) (HP:0000550)3.66953029
17Esophageal atresia (HP:0002032)3.58667216
18Optic disc pallor (HP:0000543)3.51939022
19Congenital stationary night blindness (HP:0007642)3.48020739
20Abnormality of the vocal cords (HP:0008777)3.46487048
21Depressed nasal tip (HP:0000437)3.40415370
22Acute necrotizing encephalopathy (HP:0006965)3.37479383
23Annular pancreas (HP:0001734)3.31635123
24Abnormal mitochondria in muscle tissue (HP:0008316)3.30096408
25Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)3.23067129
26Mitochondrial inheritance (HP:0001427)3.15743262
27Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.98008784
28Type II diabetes mellitus (HP:0005978)2.97339485
29Asplenia (HP:0001746)2.96870035
30Acute encephalopathy (HP:0006846)2.93679739
31Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.91765093
32Increased CSF lactate (HP:0002490)2.90542170
33Aplasia/Hypoplasia of the spleen (HP:0010451)2.85269146
34Abnormality of the 2nd finger (HP:0004100)2.85189822
35Horizontal nystagmus (HP:0000666)2.81763764
36Photophobia (HP:0000613)2.75988209
37Progressive macrocephaly (HP:0004481)2.75287268
38Abnormality of the phalanges of the 5th finger (HP:0004213)2.72968349
39Hepatocellular necrosis (HP:0001404)2.69278897
40Increased hepatocellular lipid droplets (HP:0006565)2.50442300
41Chorioretinal atrophy (HP:0000533)2.41773980
423-Methylglutaconic aciduria (HP:0003535)2.33618419
43Lipid accumulation in hepatocytes (HP:0006561)2.32328393
44Tinnitus (HP:0000360)2.31655904
45Stomatitis (HP:0010280)2.30239346
46Hepatic necrosis (HP:0002605)2.25820075
47Optic nerve hypoplasia (HP:0000609)2.24406040
48Cerebral edema (HP:0002181)2.20662024
49Severe combined immunodeficiency (HP:0004430)2.20378094
50Gastrointestinal atresia (HP:0002589)2.13243748
51Chronic hepatic failure (HP:0100626)2.11825044
52Decreased central vision (HP:0007663)2.11572314
53Absent septum pellucidum (HP:0001331)2.11453342
54Metaphyseal dysplasia (HP:0100255)2.09478779
55Thyroid-stimulating hormone excess (HP:0002925)2.09267292
56Panhypogammaglobulinemia (HP:0003139)2.06755229
57Broad-based gait (HP:0002136)2.02906761
58Posterior subcapsular cataract (HP:0007787)12.4256952
59Bilateral sensorineural hearing impairment (HP:0008619)1.98328866
60Increased serum lactate (HP:0002151)1.91904722
61Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.90788614
62Entropion (HP:0000621)1.90370540
63Severe visual impairment (HP:0001141)1.88591084
64True hermaphroditism (HP:0010459)1.88404681
65Abnormality of midbrain morphology (HP:0002418)1.88242067
66Molar tooth sign on MRI (HP:0002419)1.88242067
67Abnormality of T cell physiology (HP:0011840)1.78996829
68Pancreatic fibrosis (HP:0100732)1.77688120
69Lactic acidosis (HP:0003128)1.76293167
70Medial flaring of the eyebrow (HP:0010747)1.75856977
71Increased intramyocellular lipid droplets (HP:0012240)1.74352489
72Renal Fanconi syndrome (HP:0001994)1.74251031
73Gaze-evoked nystagmus (HP:0000640)1.72376909
74Retinitis pigmentosa (HP:0000510)1.70570981
75Abnormality of the septum pellucidum (HP:0007375)1.69959720
76Respiratory failure (HP:0002878)1.67781681
77Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.64659336
78Abnormal protein N-linked glycosylation (HP:0012347)1.64659336
79Abnormal protein glycosylation (HP:0012346)1.64659336
80Abnormal glycosylation (HP:0012345)1.64659336
81Pancreatic cysts (HP:0001737)1.64523523
82Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.63422259
83Combined immunodeficiency (HP:0005387)1.62906396
84Congenital, generalized hypertrichosis (HP:0004540)1.62562198
85Abnormality of dentin (HP:0010299)1.61903872
86Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.60651372
87Decreased activity of mitochondrial respiratory chain (HP:0008972)1.60651372
88Abnormality of T cells (HP:0002843)1.59059292
89Growth hormone deficiency (HP:0000824)1.58201577
90Neutropenia (HP:0001875)1.56640688
91Increased muscle lipid content (HP:0009058)1.54816924
92Myokymia (HP:0002411)1.53689343
93Congenital primary aphakia (HP:0007707)1.53475792
94Pustule (HP:0200039)1.52872681
95Abnormality of abdominal situs (HP:0011620)1.51935856
96Abdominal situs inversus (HP:0003363)1.51935856
97Thyroiditis (HP:0100646)1.51576521
98Sclerocornea (HP:0000647)1.51056191
99Degeneration of the lateral corticospinal tracts (HP:0002314)1.50918478
100Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.50918478

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK33.85057799
2MAP3K123.82677807
3MAP4K22.82964074
4EIF2AK32.61963121
5NEK12.54395006
6MARK32.39209482
7TAOK32.35513336
8PBK2.33476129
9GRK12.29365570
10TLK12.20109071
11ADRBK22.10213678
12BMPR1B2.08784944
13SIK21.97848891
14WNK31.93211418
15INSRR1.87736946
16TXK1.81877384
17PINK11.79890410
18PASK1.75484841
19TSSK61.74484651
20CLK11.69941460
21MAP3K111.67808698
22PRKCI1.52999056
23GRK51.51969964
24TEC1.51355022
25VRK21.48996188
26ZAK1.48554031
27CDK81.40767113
28SRPK11.37656743
29CSNK1G21.35598613
30EIF2AK11.33980644
31NUAK11.27830050
32SIK11.27330948
33CDC71.24393053
34CSNK1G31.23374227
35VRK11.19953175
36TESK21.17402492
37OXSR11.16900644
38MST41.10491184
39ITK1.09477835
40FLT31.07229486
41GRK61.05016328
42BRD41.04683380
43STK391.02930030
44CDK191.01739497
45CSNK1G11.01029377
46TAF10.96404843
47PLK40.93732910
48CSNK1A1L0.93565409
49CAMKK20.90196550
50RPS6KA50.87664740
51PIM10.78554116
52BTK0.76780706
53IKBKE0.76726121
54TNK20.74543907
55MET0.73441358
56CCNB10.72318012
57EPHA30.71778432
58BUB10.70355969
59STK160.69927559
60NLK0.67267692
61STK40.67012651
62TYK20.66144056
63MAP4K10.65835020
64FGR0.65581115
65FRK0.59465251
66NME10.58423213
67LCK0.57417599
68JAK30.57367297
69TRIM280.56355025
70WNK40.55820372
71ZAP700.55442935
72CSNK2A20.55033834
73DAPK10.53210440
74EPHB10.53119991
75PRKAA10.52647997
76TGFBR10.50763071
77FER0.49812259
78PLK20.48342878
79DYRK20.47837516
80EPHA40.47730838
81IRAK10.44140045
82PRKCE0.43686552
83AURKA0.42013444
84IKBKB0.41962597
85MAP2K70.41822103
86PNCK0.41597517
87HCK0.41125895
88CHEK20.39157938
89MAP3K40.38594177
90TESK10.38513829
91TTK0.38362782
92CAMK2A0.38332244
93PKN20.36862114
94ATR0.34914323
95PRKG20.33757533
96STK110.33487719
97WNK10.33090696
98BCKDK0.32814143
99PRKCQ0.30695152
100KIT0.30602759

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.99279247
2Oxidative phosphorylation_Homo sapiens_hsa001903.97412761
3Parkinsons disease_Homo sapiens_hsa050123.44140567
4Phototransduction_Homo sapiens_hsa047443.08157060
5Ribosome_Homo sapiens_hsa030102.90131269
6Folate biosynthesis_Homo sapiens_hsa007902.46629660
7Mismatch repair_Homo sapiens_hsa034302.45118895
8Regulation of autophagy_Homo sapiens_hsa041402.39006862
9Alzheimers disease_Homo sapiens_hsa050102.38554333
10Huntingtons disease_Homo sapiens_hsa050162.33206658
11Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.27599066
12Protein export_Homo sapiens_hsa030602.20831632
13Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.05256941
14GABAergic synapse_Homo sapiens_hsa047272.04607590
15Taste transduction_Homo sapiens_hsa047422.01892062
16Morphine addiction_Homo sapiens_hsa050321.96773840
17Basal transcription factors_Homo sapiens_hsa030221.91569489
18One carbon pool by folate_Homo sapiens_hsa006701.81997894
19RNA polymerase_Homo sapiens_hsa030201.79042319
20Homologous recombination_Homo sapiens_hsa034401.76015575
21Olfactory transduction_Homo sapiens_hsa047401.68080346
22Nitrogen metabolism_Homo sapiens_hsa009101.64878424
23RNA degradation_Homo sapiens_hsa030181.63327967
24Primary immunodeficiency_Homo sapiens_hsa053401.62934294
25Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.56941476
26Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.55043597
27Nucleotide excision repair_Homo sapiens_hsa034201.49501514
28Cardiac muscle contraction_Homo sapiens_hsa042601.48929408
29DNA replication_Homo sapiens_hsa030301.45371436
30Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.39930825
31Peroxisome_Homo sapiens_hsa041461.36358254
32Fanconi anemia pathway_Homo sapiens_hsa034601.30257105
33Glutamatergic synapse_Homo sapiens_hsa047241.27176591
34Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.26118472
35Fatty acid elongation_Homo sapiens_hsa000621.24348959
36Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.19899251
37Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.12596263
38Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.09424453
39Collecting duct acid secretion_Homo sapiens_hsa049661.07215797
40Base excision repair_Homo sapiens_hsa034101.06954068
41Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.05073941
42Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.03975378
43Purine metabolism_Homo sapiens_hsa002301.02419380
44Circadian entrainment_Homo sapiens_hsa047131.01844613
45RNA transport_Homo sapiens_hsa030131.01382358
46Ether lipid metabolism_Homo sapiens_hsa005650.96385450
47Non-homologous end-joining_Homo sapiens_hsa034500.96286767
48Selenocompound metabolism_Homo sapiens_hsa004500.91377923
49Alcoholism_Homo sapiens_hsa050340.89698983
50Pyrimidine metabolism_Homo sapiens_hsa002400.88356210
51Fatty acid biosynthesis_Homo sapiens_hsa000610.86505936
52Nicotine addiction_Homo sapiens_hsa050330.85844772
53Sulfur relay system_Homo sapiens_hsa041220.85788329
54Serotonergic synapse_Homo sapiens_hsa047260.81506682
55Linoleic acid metabolism_Homo sapiens_hsa005910.80963589
56Metabolic pathways_Homo sapiens_hsa011000.78937542
57N-Glycan biosynthesis_Homo sapiens_hsa005100.78212931
58Pyruvate metabolism_Homo sapiens_hsa006200.74960440
59Cholinergic synapse_Homo sapiens_hsa047250.71775745
60alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.68585999
61Circadian rhythm_Homo sapiens_hsa047100.67718946
62Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.66350614
63Spliceosome_Homo sapiens_hsa030400.64847896
64SNARE interactions in vesicular transport_Homo sapiens_hsa041300.63406614
65Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.59780946
66Fructose and mannose metabolism_Homo sapiens_hsa000510.59630398
67Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.58596943
68Drug metabolism - other enzymes_Homo sapiens_hsa009830.56729731
69Glutathione metabolism_Homo sapiens_hsa004800.53893811
70Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.52975896
71Propanoate metabolism_Homo sapiens_hsa006400.52131699
72Synaptic vesicle cycle_Homo sapiens_hsa047210.50353379
73Hedgehog signaling pathway_Homo sapiens_hsa043400.50121619
74Glycerophospholipid metabolism_Homo sapiens_hsa005640.49929788
75Dopaminergic synapse_Homo sapiens_hsa047280.49162878
76Systemic lupus erythematosus_Homo sapiens_hsa053220.48307926
77Legionellosis_Homo sapiens_hsa051340.45421070
78Retinol metabolism_Homo sapiens_hsa008300.44507307
79Caffeine metabolism_Homo sapiens_hsa002320.38944444
80Mineral absorption_Homo sapiens_hsa049780.37267528
81Transcriptional misregulation in cancer_Homo sapiens_hsa052020.36392835
82Basal cell carcinoma_Homo sapiens_hsa052170.35435998
83Butanoate metabolism_Homo sapiens_hsa006500.35366693
84ABC transporters_Homo sapiens_hsa020100.34197834
85Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.34085304
86Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.29273799
87Sulfur metabolism_Homo sapiens_hsa009200.26897116
88Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.26444747
89Fat digestion and absorption_Homo sapiens_hsa049750.25614889
90Cyanoamino acid metabolism_Homo sapiens_hsa004600.22089450
91Arachidonic acid metabolism_Homo sapiens_hsa005900.21769350
92Calcium signaling pathway_Homo sapiens_hsa040200.18098286
93Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.17648512
94Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.17083269
95Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.16568940
96Aldosterone synthesis and secretion_Homo sapiens_hsa049250.16028092
97Chemical carcinogenesis_Homo sapiens_hsa052040.14590808
98Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.14225707
99Adipocytokine signaling pathway_Homo sapiens_hsa049200.13794193
100Cysteine and methionine metabolism_Homo sapiens_hsa002700.11691991

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