FAAP100

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: FAAP100 is a component of the Fanconi anemia (FA; MIM 277650) core complex and is required for core complex stability and FANCD2 (see MIM 227646) monoubiquitination (Ling et al., 2007 [PubMed 17396147]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline biosynthetic process (GO:0006561)9.03544625
2DNA deamination (GO:0045006)6.83528257
3transcription from mitochondrial promoter (GO:0006390)6.81628997
4proline metabolic process (GO:0006560)6.52351898
5replication fork processing (GO:0031297)6.42637495
6maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)5.46830611
7embryonic process involved in female pregnancy (GO:0060136)5.43884386
8positive regulation of protein homooligomerization (GO:0032464)5.30833589
9mannose metabolic process (GO:0006013)5.29042605
10regulation of integrin activation (GO:0033623)5.08349488
11DNA strand renaturation (GO:0000733)5.04349431
12negative regulation of erythrocyte differentiation (GO:0045647)5.01856498
13mitochondrial DNA metabolic process (GO:0032042)5.01041073
14dosage compensation (GO:0007549)5.00610923
15oxidative demethylation (GO:0070989)4.89913592
16establishment of apical/basal cell polarity (GO:0035089)4.79087688
17somatic diversification of immune receptors via somatic mutation (GO:0002566)4.63953457
18somatic hypermutation of immunoglobulin genes (GO:0016446)4.63953457
19poly(A)+ mRNA export from nucleus (GO:0016973)4.62676281
20negative regulation of cell size (GO:0045792)4.62491578
21regulation of protein homooligomerization (GO:0032462)4.61999162
22negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.56337401
23establishment or maintenance of monopolar cell polarity (GO:0061339)4.51295179
24establishment of monopolar cell polarity (GO:0061162)4.51295179
25telomere maintenance via semi-conservative replication (GO:0032201)4.49332471
26negative regulation of JAK-STAT cascade (GO:0046426)4.38496201
27viral mRNA export from host cell nucleus (GO:0046784)4.38346123
28base-excision repair (GO:0006284)4.27956160
29semaphorin-plexin signaling pathway (GO:0071526)4.26664967
30DNA strand elongation involved in DNA replication (GO:0006271)4.14396222
31protein retention in ER lumen (GO:0006621)4.11359852
32negative regulation of cell cycle arrest (GO:0071157)4.10086646
33nucleotide-excision repair, DNA gap filling (GO:0006297)4.08123299
34Golgi transport vesicle coating (GO:0048200)4.05655660
35COPI coating of Golgi vesicle (GO:0048205)4.05655660
36DNA double-strand break processing (GO:0000729)4.05354200
37histone H4-K12 acetylation (GO:0043983)4.04260466
38spliceosomal tri-snRNP complex assembly (GO:0000244)4.01705204
39mitotic G1 DNA damage checkpoint (GO:0031571)4.00082324
40regulation of mammary gland epithelial cell proliferation (GO:0033599)3.97548016
41negative regulation of mRNA processing (GO:0050686)3.94951622
42DNA ligation (GO:0006266)3.90754649
43regulation of translational fidelity (GO:0006450)3.90684559
44DNA strand elongation (GO:0022616)3.89338870
45mRNA cleavage (GO:0006379)3.88040262
46formation of translation preinitiation complex (GO:0001731)3.80468497
47positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.76964307
48termination of RNA polymerase II transcription (GO:0006369)3.74653753
49negative regulation of RNA splicing (GO:0033119)3.71561173
50maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.66363755
51telomere maintenance via recombination (GO:0000722)3.61209030
52negative regulation of Ras GTPase activity (GO:0034261)3.59709982
53DNA integration (GO:0015074)3.57172653
54non-recombinational repair (GO:0000726)3.55295879
55double-strand break repair via nonhomologous end joining (GO:0006303)3.55295879
56cellular response to zinc ion (GO:0071294)3.55263400
57pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.54597476
58planar cell polarity pathway involved in neural tube closure (GO:0090179)3.53623678
59regulation of DNA damage checkpoint (GO:2000001)3.52303346
60face development (GO:0060324)3.51750083
61G1 DNA damage checkpoint (GO:0044783)3.47732157
62convergent extension (GO:0060026)3.47175972
63mitochondrial RNA metabolic process (GO:0000959)3.45081089
64base-excision repair, AP site formation (GO:0006285)3.43993971
65DNA topological change (GO:0006265)3.43093034
66histone arginine methylation (GO:0034969)3.42540531
67pentose-phosphate shunt (GO:0006098)3.40197168
68peptidyl-arginine omega-N-methylation (GO:0035247)3.39761187
69mitotic G1/S transition checkpoint (GO:0044819)3.38966609
70establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.37055342
71mitochondrion transport along microtubule (GO:0047497)3.37055342
72UV protection (GO:0009650)3.36531102
73retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.30582930
74cell migration in hindbrain (GO:0021535)3.30463645
75modulation by virus of host process (GO:0019054)3.28591098
76meiotic chromosome segregation (GO:0045132)3.27463930
77positive regulation of histone deacetylation (GO:0031065)3.24589938
78barbed-end actin filament capping (GO:0051016)3.24502342
79adherens junction assembly (GO:0034333)3.24380825
80embryonic camera-type eye development (GO:0031076)3.21366968
81regulation of chromatin binding (GO:0035561)3.21286903
82embryonic placenta development (GO:0001892)3.21261796
83positive regulation of developmental pigmentation (GO:0048087)3.19040916
84regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.18605497
85activation of Rac GTPase activity (GO:0032863)3.17638741
86negative regulation of mRNA metabolic process (GO:1903312)3.17604700
87protein localization to endosome (GO:0036010)3.16839260
88pyrimidine nucleobase catabolic process (GO:0006208)3.15391572
89focal adhesion assembly (GO:0048041)3.15164461
90cell-substrate adherens junction assembly (GO:0007045)3.15164461
91glucose catabolic process (GO:0006007)3.12354607
92modulation by symbiont of host cellular process (GO:0044068)3.12303956
93apoptotic process involved in morphogenesis (GO:0060561)3.10942170
94DNA demethylation (GO:0080111)3.10669021
95positive regulation by host of viral transcription (GO:0043923)3.10644525
96regulation of ARF GTPase activity (GO:0032312)3.09155607
97regulation of double-strand break repair via homologous recombination (GO:0010569)3.07623225
98mitotic recombination (GO:0006312)3.06910473
99regulation of cilium movement (GO:0003352)3.06164835
100pyrimidine nucleotide catabolic process (GO:0006244)3.06069051
101NIK/NF-kappaB signaling (GO:0038061)3.04737290
102single strand break repair (GO:0000012)3.04639915
103snRNA metabolic process (GO:0016073)3.04567813
104histone H4 deacetylation (GO:0070933)3.03783841
105telomere maintenance via telomere lengthening (GO:0010833)3.03762099
106regulation of glucose import in response to insulin stimulus (GO:2001273)3.02857129
107maturation of 5.8S rRNA (GO:0000460)3.00666483
108stress fiber assembly (GO:0043149)3.00183380
109regulation of cAMP-dependent protein kinase activity (GO:2000479)2.97475836
110negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.96004321
111glial cell migration (GO:0008347)2.94450277
112intracellular estrogen receptor signaling pathway (GO:0030520)2.94065623
113epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.93786268
114regulation of sister chromatid cohesion (GO:0007063)2.93383615
115GDP-mannose metabolic process (GO:0019673)2.93269587
116cell-cell junction maintenance (GO:0045217)2.93121652
1173-UTR-mediated mRNA stabilization (GO:0070935)2.92880758
118regulation of type I interferon-mediated signaling pathway (GO:0060338)2.91174471
119basement membrane organization (GO:0071711)2.90897218
120mitotic nuclear envelope reassembly (GO:0007084)2.90491522
121nuclear envelope reassembly (GO:0031468)2.90491522
122negative regulation of protein oligomerization (GO:0032460)2.89928498
123positive regulation of protein oligomerization (GO:0032461)2.89776624
124activation of MAPKKK activity (GO:0000185)2.89492730
125positive regulation of Cdc42 GTPase activity (GO:0043089)2.89423614
126establishment of protein localization to mitochondrial membrane (GO:0090151)2.87238619
127negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.86787926
128negative regulation of fatty acid transport (GO:2000192)2.86296584
129pinocytosis (GO:0006907)2.85830371
130positive regulation of blood vessel endothelial cell migration (GO:0043536)2.85634119
131NADPH regeneration (GO:0006740)2.85621261
132maternal placenta development (GO:0001893)2.85614977
133positive regulation of microtubule polymerization (GO:0031116)2.82182240
134anatomical structure regression (GO:0060033)2.80565937
135regulation of protein oligomerization (GO:0032459)2.80088281
136cellular response to virus (GO:0098586)2.79660809
137spinal cord development (GO:0021510)2.78210422
138activation of JUN kinase activity (GO:0007257)2.77896475
139epithelial cilium movement (GO:0003351)2.77178568
140glutamine family amino acid biosynthetic process (GO:0009084)2.76954481
141regulation of double-strand break repair (GO:2000779)2.76923943
142cell-substrate junction assembly (GO:0007044)2.76651774
143response to laminar fluid shear stress (GO:0034616)2.76441626
144regulation of RNA export from nucleus (GO:0046831)2.76433701
145peptidyl-arginine N-methylation (GO:0035246)2.76152812
146peptidyl-arginine methylation (GO:0018216)2.76152812
147respiratory system process (GO:0003016)2.74932299
148regulation of extracellular matrix disassembly (GO:0010715)2.74612334
149negative regulation of viral release from host cell (GO:1902187)2.71909478
150mRNA export from nucleus (GO:0006406)2.71102560
151cellular response to ATP (GO:0071318)2.70987053
152atrioventricular valve morphogenesis (GO:0003181)2.68929496
153snRNA processing (GO:0016180)2.68607066
154retrograde transport, endosome to Golgi (GO:0042147)2.65604521
155histone H3 deacetylation (GO:0070932)2.65601465
156epithelial cell differentiation involved in prostate gland development (GO:0060742)2.63817688
157response to muramyl dipeptide (GO:0032495)2.62946613
158regulation of early endosome to late endosome transport (GO:2000641)2.62039095
159apoptotic process involved in development (GO:1902742)2.60091996
160response to peptidoglycan (GO:0032494)2.56119979
161protein insertion into membrane (GO:0051205)2.54477541
162regulation of NFAT protein import into nucleus (GO:0051532)2.53917386
163modulation by virus of host morphology or physiology (GO:0019048)2.51630738
164positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.50925530
165peptidyl-lysine dimethylation (GO:0018027)2.50064936
166thymic T cell selection (GO:0045061)2.48679361
167positive regulation of protein deacetylation (GO:0090312)2.48300687
168nucleosome disassembly (GO:0006337)2.46886209
169protein-DNA complex disassembly (GO:0032986)2.46886209
170cellular response to interleukin-4 (GO:0071353)2.43868488
171regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.43530052
172positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.42877271
173vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.42302945
174activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.42205621
175glucose 6-phosphate metabolic process (GO:0051156)2.39990687
176regulation of cholesterol biosynthetic process (GO:0045540)2.39760576
177protein maturation by protein folding (GO:0022417)2.36743334
178positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.36716350
179positive regulation of receptor recycling (GO:0001921)2.36479961
180positive thymic T cell selection (GO:0045059)2.33454146
181negative regulation of myotube differentiation (GO:0010832)2.32861020
182protein targeting to plasma membrane (GO:0072661)2.32336032
183epithelial cell-cell adhesion (GO:0090136)2.31406086
184positive regulation of nuclease activity (GO:0032075)2.31376046
185regulation of defense response to virus by virus (GO:0050690)2.27935661
186negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.27654056
187antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.26949661
188actin filament bundle organization (GO:0061572)2.26179604

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human3.48063195
2ZFP281_18358816_ChIP-ChIP_MESCs_Mouse3.13295548
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.01279293
4SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.96929371
5VDR_21846776_ChIP-Seq_THP-1_Human2.91949825
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.67174293
7TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.52671461
8THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.50000968
9RARG_19884340_ChIP-ChIP_MEFs_Mouse2.33880765
10MYC_19079543_ChIP-ChIP_MESCs_Mouse2.32757626
11MYC_18358816_ChIP-ChIP_MESCs_Mouse2.29868791
12DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.29066347
13LXR_22292898_ChIP-Seq_THP-1_Human2.28323799
14KLF4_18358816_ChIP-ChIP_MESCs_Mouse2.26761874
15MYC_22102868_ChIP-Seq_BL_Human2.24559121
16EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.18064874
17SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.16915964
18TP63_17297297_ChIP-ChIP_HaCaT_Human2.08230793
19NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.02627655
20RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.97945142
21NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.95781066
22DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.92285494
23FOXM1_23109430_ChIP-Seq_U2OS_Human1.85220410
24SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.81433120
25CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.81008659
26MYC_19030024_ChIP-ChIP_MESCs_Mouse1.79055767
27PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.78127583
28ZFP281_18757296_ChIP-ChIP_E14_Mouse1.75828518
29VDR_24763502_ChIP-Seq_THP-1_Human1.74338035
30NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.72921192
31TET1_21451524_ChIP-Seq_MESCs_Mouse1.71568853
32NANOG_21062744_ChIP-ChIP_HESCs_Human1.71057965
33THAP11_20581084_ChIP-Seq_MESCs_Mouse1.70027384
34POU5F1_16518401_ChIP-PET_MESCs_Mouse1.67187934
35SA1_27219007_Chip-Seq_ERYTHROID_Human1.66331419
36HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.65292688
37YY1_21170310_ChIP-Seq_MESCs_Mouse1.64983214
38RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.64388121
39TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.64078031
40KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.63879961
41KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.63879961
42KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.63879961
43MAF_26560356_Chip-Seq_TH2_Human1.63051021
44KDM2B_26808549_Chip-Seq_SUP-B15_Human1.60927887
45CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.59775828
46PU.1_20513432_ChIP-Seq_Bcells_Mouse1.59695143
47MAF_26560356_Chip-Seq_TH1_Human1.57703143
48EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.57193784
49JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.56547763
50FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.54666788
51UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.54562482
52KDM2B_26808549_Chip-Seq_DND41_Human1.53437078
53NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.51864052
54ELF1_20517297_ChIP-Seq_JURKAT_Human1.50892215
55SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.47864120
56NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.47652847
57KDM2B_26808549_Chip-Seq_JURKAT_Human1.47128774
58UTX_26944678_Chip-Seq_JUKART_Human1.47040031
59ERG_21242973_ChIP-ChIP_JURKAT_Human1.46467429
60SMC4_20622854_ChIP-Seq_HELA_Human1.46168251
61MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.45934923
62KLF4_18555785_ChIP-Seq_MESCs_Mouse1.45763069
63SOX2_18555785_ChIP-Seq_MESCs_Mouse1.45639168
64ZFP281_27345836_Chip-Seq_ESCs_Mouse1.45352218
65ZNF263_19887448_ChIP-Seq_K562_Human1.44817540
66STAT6_21828071_ChIP-Seq_BEAS2B_Human1.44694384
67CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.44655215
68XRN2_22483619_ChIP-Seq_HELA_Human1.42570463
69STAT3_1855785_ChIP-Seq_MESCs_Mouse1.42320153
70ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.41286717
71CREB1_26743006_Chip-Seq_LNCaP_Human1.39163168
72TCF3_18692474_ChIP-Seq_MESCs_Mouse1.39142205
73E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.39107959
74BCOR_27268052_Chip-Seq_Bcells_Human1.38252692
75ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.38080726
76KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.37055356
77TTF2_22483619_ChIP-Seq_HELA_Human1.37030828
78YY1_22570637_ChIP-Seq_MALME-3M_Human1.36746619
79MYCN_18555785_ChIP-Seq_MESCs_Mouse1.35552944
80SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.35086378
81TP53_22127205_ChIP-Seq_IMR90_Human1.34692976
82KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.33681986
83POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.33570261
84CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.33233966
85NANOG_18555785_ChIP-Seq_MESCs_Mouse1.33070362
86GABP_19822575_ChIP-Seq_HepG2_Human1.32719452
87POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.32578694
88NCOR1_26117541_ChIP-Seq_K562_Human1.29749521
89DNAJC2_21179169_ChIP-ChIP_NT2_Human1.29620154
90RUNX1_22412390_ChIP-Seq_EML_Mouse1.29128592
91RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.27666874
92EGR1_19374776_ChIP-ChIP_THP-1_Human1.26765403
93E2F1_18555785_ChIP-Seq_MESCs_Mouse1.26732941
94CTCF_21964334_ChIP-Seq_BJAB-B_Human1.26264532
95SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.25177721
96P300_27058665_Chip-Seq_ZR-75-30cells_Human1.24847367
97POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.24831953
98CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.23992682
99TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.23847372
100PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.22864918
101ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.22208917
102SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.21901961
103TCF7_22412390_ChIP-Seq_EML_Mouse1.21741032
104ETS1_21867929_ChIP-Seq_TH2_Mouse1.21463113
105PHF8_20622854_ChIP-Seq_HELA_Human1.21206865
106SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.21191512
107KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.20870055
108SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.20517984
109DCP1A_22483619_ChIP-Seq_HELA_Human1.20448993
110CTCF_27219007_Chip-Seq_Bcells_Human1.20343084
111MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.19135077
112RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.18659240
113TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.18071525
114KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.18062323
115MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.17998244
116ESR2_21235772_ChIP-Seq_MCF-7_Human1.17165094
117ETS1_20019798_ChIP-Seq_JURKAT_Human1.16833950
118CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.16282968
119SRY_22984422_ChIP-ChIP_TESTIS_Rat1.16257167
120POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.16156207
121MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.16119023
122BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.16048922
123ATF3_27146783_Chip-Seq_COLON_Human1.16038133
124ELK3_25401928_ChIP-Seq_HUVEC_Human1.15510999
125P68_20966046_ChIP-Seq_HELA_Human1.14540020
126TCF3_18692474_ChIP-Seq_MEFs_Mouse1.14282113
127NELFA_20434984_ChIP-Seq_ESCs_Mouse1.13820170
128CTCF_26484167_Chip-Seq_Bcells_Mouse1.13703322
129CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.13669708
130ZFX_18555785_ChIP-Seq_MESCs_Mouse1.13296189
131E2F1_20622854_ChIP-Seq_HELA_Human1.12984115
132RACK7_27058665_Chip-Seq_MCF-7_Human1.12426794
133E2F4_17652178_ChIP-ChIP_JURKAT_Human1.12014471
134GATA1_22383799_ChIP-Seq_G1ME_Mouse1.11910837
135CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.11728733
136RARB_24833708_ChIP-Seq_LIVER_Mouse1.11164748
137SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.11152869
138BCL6_27268052_Chip-Seq_Bcells_Human1.10499914
139CTCF_21964334_Chip-Seq_Bcells_Human1.10451347
140RARA_24833708_ChIP-Seq_LIVER_Mouse1.10346224
141BRD4_27068464_Chip-Seq_AML-cells_Mouse1.09924785
142SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.08663327
143KDM2B_26808549_Chip-Seq_K562_Human1.08345739
144MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.08307971
145FOXP1_21924763_ChIP-Seq_HESCs_Human1.08119453
146TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.07866482
147KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.07811159
148NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.07570023
149TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.07512557
150CIITA_25753668_ChIP-Seq_RAJI_Human1.07450268
151SOX2_18692474_ChIP-Seq_MESCs_Mouse1.07272327
152CTCF_27219007_Chip-Seq_ERYTHROID_Human1.06741980
153WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.06078348
154KDM5A_27292631_Chip-Seq_BREAST_Human1.05687736
155RUNX1_27514584_Chip-Seq_MCF-7_Human1.02586754
156MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.01367944

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.89142955
2MP0003705_abnormal_hypodermis_morpholog4.86579724
3MP0009278_abnormal_bone_marrow4.20036279
4MP0010030_abnormal_orbit_morphology3.85665587
5MP0005058_abnormal_lysosome_morphology3.46003998
6MP0004233_abnormal_muscle_weight3.13111853
7MP0005451_abnormal_body_composition2.97898728
8MP0008995_early_reproductive_senescence2.79476583
9MP0004858_abnormal_nervous_system2.79142554
10MP0010094_abnormal_chromosome_stability2.77817379
11MP0001849_ear_inflammation2.76487065
12MP0008260_abnormal_autophagy2.68870555
13MP0005174_abnormal_tail_pigmentation2.61448642
14MP0008438_abnormal_cutaneous_collagen2.45696746
15MP0002009_preneoplasia2.33039015
16MP0005171_absent_coat_pigmentation2.29664004
17MP0002653_abnormal_ependyma_morphology2.29414652
18MP0003119_abnormal_digestive_system2.24358698
19MP0001545_abnormal_hematopoietic_system2.21704079
20MP0005397_hematopoietic_system_phenotyp2.21704079
21MP0002282_abnormal_trachea_morphology2.17603091
22MP0003566_abnormal_cell_adhesion2.11836683
23MP0008058_abnormal_DNA_repair2.08143307
24MP0003436_decreased_susceptibility_to2.07355781
25MP0008877_abnormal_DNA_methylation2.05977487
26MP0003279_aneurysm2.03608727
27MP0002249_abnormal_larynx_morphology2.01241533
28MP0003890_abnormal_embryonic-extraembry1.99853161
29MP0006072_abnormal_retinal_apoptosis1.99767717
30MP0003111_abnormal_nucleus_morphology1.89898751
31MP0005257_abnormal_intraocular_pressure1.86629191
32MP0004133_heterotaxia1.83458991
33MP0004185_abnormal_adipocyte_glucose1.80785430
34MP0003786_premature_aging1.79414627
35MP0000015_abnormal_ear_pigmentation1.78191757
36MP0009840_abnormal_foam_cell1.76695728
37MP0005409_darkened_coat_color1.71911700
38MP0004957_abnormal_blastocyst_morpholog1.71238774
39MP0003091_abnormal_cell_migration1.70638282
40MP0000003_abnormal_adipose_tissue1.69360840
41MP0003077_abnormal_cell_cycle1.68108446
42MP0003303_peritoneal_inflammation1.68017421
43MP0003191_abnormal_cellular_cholesterol1.63530933
44MP0005076_abnormal_cell_differentiation1.59478767
45MP0000490_abnormal_crypts_of1.58799363
46MP0008932_abnormal_embryonic_tissue1.58789997
47MP0002084_abnormal_developmental_patter1.55828104
48MP0010352_gastrointestinal_tract_polyps1.53877917
49MP0001697_abnormal_embryo_size1.51994355
50MP0001958_emphysema1.49823177
51MP0004197_abnormal_fetal_growth/weight/1.47022720
52MP0009384_cardiac_valve_regurgitation1.46673977
53MP0003693_abnormal_embryo_hatching1.42977871
54MP0005501_abnormal_skin_physiology1.42337174
55MP0000858_altered_metastatic_potential1.42286097
56MP0002085_abnormal_embryonic_tissue1.42160733
57MP0004947_skin_inflammation1.41881371
58MP0005410_abnormal_fertilization1.38918843
59MP0005645_abnormal_hypothalamus_physiol1.37940918
60MP0000371_diluted_coat_color1.36801749
61MP0003300_gastrointestinal_ulcer1.35749461
62MP0005375_adipose_tissue_phenotype1.35230393
63MP0002254_reproductive_system_inflammat1.33989932
64MP0005075_abnormal_melanosome_morpholog1.32302950
65MP0003137_abnormal_impulse_conducting1.31776275
66MP0003567_abnormal_fetal_cardiomyocyte1.30917983
67MP0002086_abnormal_extraembryonic_tissu1.29429665
68MP0003283_abnormal_digestive_organ1.28990499
69MP0002396_abnormal_hematopoietic_system1.28361614
70MP0005666_abnormal_adipose_tissue1.28001087
71MP0001293_anophthalmia1.26770638
72MP0001348_abnormal_lacrimal_gland1.25653093
73MP0000579_abnormal_nail_morphology1.23922376
74MP0002877_abnormal_melanocyte_morpholog1.23744626
75MP0000767_abnormal_smooth_muscle1.23586345
76MP0003172_abnormal_lysosome_physiology1.21417390
77MP0000733_abnormal_muscle_development1.21112677
78MP0001873_stomach_inflammation1.19355134
79MP0004381_abnormal_hair_follicle1.18991942
80MP0000350_abnormal_cell_proliferation1.18968768
81MP0000049_abnormal_middle_ear1.18290989
82MP0002060_abnormal_skin_morphology1.17757963
83MP0000462_abnormal_digestive_system1.17474851
84MP0000778_abnormal_nervous_system1.16255244
85MP0001672_abnormal_embryogenesis/_devel1.13513618
86MP0005380_embryogenesis_phenotype1.13513618
87MP0000013_abnormal_adipose_tissue1.12563565
88MP0003385_abnormal_body_wall1.11697998
89MP0000750_abnormal_muscle_regeneration1.11544045
90MP0001730_embryonic_growth_arrest1.11328982
91MP0001929_abnormal_gametogenesis1.07264090
92MP0000747_muscle_weakness1.05715076
93MP0002933_joint_inflammation1.05648350
94MP0005621_abnormal_cell_physiology1.04924908
95MP0005623_abnormal_meninges_morphology1.04494209
96MP0002751_abnormal_autonomic_nervous1.04230609
97MP0002932_abnormal_joint_morphology1.03972830
98MP0001145_abnormal_male_reproductive1.03500569
99MP0002080_prenatal_lethality1.02204415
100MP0002210_abnormal_sex_determination1.02042557
101MP0003698_abnormal_male_reproductive1.01560689
102MP0002269_muscular_atrophy0.99595828
103MP0000470_abnormal_stomach_morphology0.97492377
104MP0000759_abnormal_skeletal_muscle0.96729669
105MP0004808_abnormal_hematopoietic_stem0.96194124
106MP0000681_abnormal_thyroid_gland0.96102325
107MP0009931_abnormal_skin_appearance0.95956290
108MP0000751_myopathy0.95635224
109MP0003861_abnormal_nervous_system0.95505856
110MP0005023_abnormal_wound_healing0.94729061
111MP0002019_abnormal_tumor_incidence0.93718042
112MP0002075_abnormal_coat/hair_pigmentati0.93712934
113MP0003935_abnormal_craniofacial_develop0.93530083
114MP0010234_abnormal_vibrissa_follicle0.92867442
115MP0002116_abnormal_craniofacial_bone0.91951610
116MP0003984_embryonic_growth_retardation0.91015606
117MP0003942_abnormal_urinary_system0.90714654
118MP0001324_abnormal_eye_pigmentation0.90236816
119MP0003755_abnormal_palate_morphology0.89199114
120MP0002088_abnormal_embryonic_growth/wei0.88275985
121MP0003329_amyloid_beta_deposits0.88236761
122MP0000537_abnormal_urethra_morphology0.87956733
123MP0004272_abnormal_basement_membrane0.87197201
124MP0001340_abnormal_eyelid_morphology0.87042816
125MP0005330_cardiomyopathy0.84441815
126MP0002419_abnormal_innate_immunity0.83592927
127MP0009053_abnormal_anal_canal0.83148506
128MP0002114_abnormal_axial_skeleton0.82779784
129MP0005025_abnormal_response_to0.82759383
130MP0004510_myositis0.82754064
131MP0000313_abnormal_cell_death0.82439272
132MP0000685_abnormal_immune_system0.81692442
133MP0002398_abnormal_bone_marrow0.81088666
134MP0005670_abnormal_white_adipose0.80867459
135MP0000955_abnormal_spinal_cord0.80705091
136MP0002998_abnormal_bone_remodeling0.80521252
137MP0002161_abnormal_fertility/fecundity0.80505244
138MP0002111_abnormal_tail_morphology0.79330683
139MP0001661_extended_life_span0.78946564
140MP0005083_abnormal_biliary_tract0.78191982
141MP0000653_abnormal_sex_gland0.77176492
142MP0002938_white_spotting0.77033074
143MP0005508_abnormal_skeleton_morphology0.76746343
144MP0002697_abnormal_eye_size0.75871909
145MP0005360_urolithiasis0.75766066
146MP0005390_skeleton_phenotype0.75249923
147MP0002796_impaired_skin_barrier0.75057525
148MP0000467_abnormal_esophagus_morphology0.74309387
149MP0005391_vision/eye_phenotype0.74115425
150MP0002822_catalepsy0.73929393
151MP0003115_abnormal_respiratory_system0.73869946
152MP0005384_cellular_phenotype0.73847958
153MP0002429_abnormal_blood_cell0.73645123
154MP0010630_abnormal_cardiac_muscle0.73158964
155MP0002089_abnormal_postnatal_growth/wei0.73142655
156MP0003763_abnormal_thymus_physiology0.71649155
157MP0002970_abnormal_white_adipose0.71488287
158MP0001533_abnormal_skeleton_physiology0.71426777
159MP0001915_intracranial_hemorrhage0.70078599
160MP0003828_pulmonary_edema0.69917107
161MP0004811_abnormal_neuron_physiology0.69410287
162MP0001819_abnormal_immune_cell0.68691913
163MP0005253_abnormal_eye_physiology0.68563765
164MP0004087_abnormal_muscle_fiber0.68472495
165MP0002420_abnormal_adaptive_immunity0.67915549
166MP0002722_abnormal_immune_system0.67852038
167MP0001186_pigmentation_phenotype0.67238783
168MP0010155_abnormal_intestine_physiology0.67210574
169MP0000477_abnormal_intestine_morphology0.66950029
170MP0000678_abnormal_parathyroid_gland0.65496734
171MP0009333_abnormal_splenocyte_physiolog0.62333202
172MP0002081_perinatal_lethality0.62244052
173MP0003453_abnormal_keratinocyte_physiol0.61869369
174MP0000703_abnormal_thymus_morphology0.61515536

Predicted human phenotypes

RankGene SetZ-score
1Concave nail (HP:0001598)5.44581865
2Facial hemangioma (HP:0000329)4.54747577
3Poikiloderma (HP:0001029)4.30870382
4Rib fusion (HP:0000902)4.05377367
5Increased IgM level (HP:0003496)3.98012973
6Annular pancreas (HP:0001734)3.84952541
7Tongue fasciculations (HP:0001308)3.63467588
8Turricephaly (HP:0000262)3.57102908
9Thin bony cortex (HP:0002753)3.55263025
10Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.52988214
11Pustule (HP:0200039)3.40140749
12Muscle fibrillation (HP:0010546)3.37417185
13Absent thumb (HP:0009777)3.29507033
14Broad alveolar ridges (HP:0000187)3.28560428
15Rectovaginal fistula (HP:0000143)3.28236859
16Rectal fistula (HP:0100590)3.28236859
17Male infertility (HP:0003251)3.25751516
18Abnormality of the aortic arch (HP:0012303)3.22828157
19Broad face (HP:0000283)3.20087740
20Hemorrhage of the eye (HP:0011885)3.14945739
21Protrusio acetabuli (HP:0003179)3.14699159
22Aplasia/hypoplasia of the humerus (HP:0006507)3.10950318
23Abnormality of male internal genitalia (HP:0000022)3.09849497
24Premature rupture of membranes (HP:0001788)3.07995803
25Ulnar bowing (HP:0003031)3.06573062
26Coronal craniosynostosis (HP:0004440)3.03456046
27Short humerus (HP:0005792)3.03120249
28Albinism (HP:0001022)3.02886907
29Intestinal fistula (HP:0100819)3.02038869
30Intestinal atresia (HP:0011100)2.96993917
31Alopecia of scalp (HP:0002293)2.90793571
32Abnormality of the lower motor neuron (HP:0002366)2.90448789
33Anteriorly placed anus (HP:0001545)2.89741831
34Patellar aplasia (HP:0006443)2.88902630
35Vaginal fistula (HP:0004320)2.88420954
36Orthostatic hypotension (HP:0001278)2.85874248
37Cervical subluxation (HP:0003308)2.85106261
38Distal lower limb amyotrophy (HP:0008944)2.83812186
39Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.83693733
40Vertebral hypoplasia (HP:0008417)2.83693733
41Upper limb amyotrophy (HP:0009129)2.81046185
42Distal upper limb amyotrophy (HP:0007149)2.81046185
43Large for gestational age (HP:0001520)2.80104128
44Congenital hip dislocation (HP:0001374)2.75759019
45Selective tooth agenesis (HP:0001592)2.75101480
46Choanal stenosis (HP:0000452)2.72967130
47Stridor (HP:0010307)2.72142701
48Premature skin wrinkling (HP:0100678)2.71225146
49Long palpebral fissure (HP:0000637)2.68968981
50Aplasia/Hypoplasia of the patella (HP:0006498)2.68849104
51Abnormal hemoglobin (HP:0011902)2.66441573
52Squamous cell carcinoma (HP:0002860)2.65967817
53Absent radius (HP:0003974)2.59472239
54Hamartoma (HP:0010566)2.59353032
55Biconcave vertebral bodies (HP:0004586)2.59345759
56Bifid uvula (HP:0000193)2.58094643
57J-shaped sella turcica (HP:0002680)2.57794509
58Increased connective tissue (HP:0009025)2.57379205
59Abnormality of the thoracic spine (HP:0100711)2.57020936
60Disproportionate tall stature (HP:0001519)2.53911332
61Abnormality of the astrocytes (HP:0100707)2.53360758
62Astrocytoma (HP:0009592)2.53360758
63Basal cell carcinoma (HP:0002671)2.53352714
64Short chin (HP:0000331)2.53172285
65Pancreatic islet-cell hyperplasia (HP:0004510)2.51515905
66Capillary hemangiomas (HP:0005306)2.51421995
67Achilles tendon contracture (HP:0001771)2.48711501
68Abnormal respiratory epithelium morphology (HP:0012253)2.44600371
69Abnormal respiratory motile cilium morphology (HP:0005938)2.44600371
70Absent forearm bone (HP:0003953)2.44098263
71Aplasia involving forearm bones (HP:0009822)2.44098263
72Mitral regurgitation (HP:0001653)2.43943163
73Alacrima (HP:0000522)2.43750686
74Thoracic kyphosis (HP:0002942)2.42006100
75Myopathic facies (HP:0002058)2.39510403
76Shallow orbits (HP:0000586)2.37659365
77Vertebral compression fractures (HP:0002953)2.36643069
78Abnormality of the labia minora (HP:0012880)2.33354610
79Testicular atrophy (HP:0000029)2.31110335
80Amyotrophic lateral sclerosis (HP:0007354)2.28883314
81Centrally nucleated skeletal muscle fibers (HP:0003687)2.28506332
82Acute lymphatic leukemia (HP:0006721)2.27939980
83Premature graying of hair (HP:0002216)2.27650905
84Hypotrichosis (HP:0001006)2.26630928
85Pointed chin (HP:0000307)2.26206180
86Increased number of teeth (HP:0011069)2.26112672
87Easy fatigability (HP:0003388)2.25915253
88Ependymoma (HP:0002888)2.24866582
89Aplasia of the musculature (HP:0100854)2.21088772
90Abnormality of the ileum (HP:0001549)2.20892942
91Hypochromic microcytic anemia (HP:0004840)2.20616443
92Obstructive sleep apnea (HP:0002870)2.19821889
93Dysostosis multiplex (HP:0000943)2.19491189
94Cellulitis (HP:0100658)2.19376374
95Progressive sensorineural hearing impairment (HP:0000408)2.19219553
96Renal duplication (HP:0000075)2.15515015
97Lymphangioma (HP:0100764)2.15259427
98Short 5th finger (HP:0009237)2.14827784
99Vertebral fusion (HP:0002948)2.14406596
100Colitis (HP:0002583)2.13702435
101Fragile skin (HP:0001030)2.13255734
102Growth hormone excess (HP:0000845)2.11568879
103Abnormality of the Achilles tendon (HP:0005109)2.11020531
104Hyperacusis (HP:0010780)2.10274179
105Thin ribs (HP:0000883)2.10143764
106Hand muscle atrophy (HP:0009130)2.09807251
107Hypercortisolism (HP:0001578)2.09282959
108Cerebral aneurysm (HP:0004944)2.06847841
109Hypoplasia of the radius (HP:0002984)2.05195655
110Urinary glycosaminoglycan excretion (HP:0003541)2.05074570
111Mucopolysacchariduria (HP:0008155)2.05074570
112Distal lower limb muscle weakness (HP:0009053)2.05030276
113Genu recurvatum (HP:0002816)2.03579686
114Hypotelorism (HP:0000601)2.03530866
115Blue sclerae (HP:0000592)2.03103491
116Difficulty climbing stairs (HP:0003551)2.02106697
117Polycythemia (HP:0001901)2.01712024
118Bladder diverticulum (HP:0000015)2.01471544
119Infertility (HP:0000789)2.00542143
120Increased variability in muscle fiber diameter (HP:0003557)1.97969074
121Mildly elevated creatine phosphokinase (HP:0008180)1.97658818
122Narrow nasal bridge (HP:0000446)1.97508276
123Atrophy/Degeneration involving motor neurons (HP:0007373)1.97360480
124Atrophic scars (HP:0001075)1.97136588
125Dysautonomia (HP:0002459)1.96034515
126Muscle fiber atrophy (HP:0100295)1.95855766
127Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.95792499
128Short 4th metacarpal (HP:0010044)1.95792499
129Degeneration of anterior horn cells (HP:0002398)1.95501539
130Abnormality of the anterior horn cell (HP:0006802)1.95501539
131Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.95255582
132Bulbar palsy (HP:0001283)1.93355359
133Heterotopia (HP:0002282)1.93169252
134Joint stiffness (HP:0001387)1.93131040
135Neoplasm of the oral cavity (HP:0100649)1.91862218
136Hypertensive crisis (HP:0100735)1.90998417
137Spinal rigidity (HP:0003306)1.90563435
138Short thumb (HP:0009778)1.90490554
139Abnormal number of incisors (HP:0011064)1.89582804
140Abnormality of polysaccharide metabolism (HP:0011012)1.88815912
141Abnormality of glycosaminoglycan metabolism (HP:0004371)1.88815912
142Abnormality of mucopolysaccharide metabolism (HP:0011020)1.88815912
143Flattened epiphyses (HP:0003071)1.87598500
144Volvulus (HP:0002580)1.87491067
145Eczematoid dermatitis (HP:0000976)1.87252923
146Broad distal phalanx of finger (HP:0009836)1.87061191
147Emphysema (HP:0002097)1.86049960
148Asymmetry of the thorax (HP:0001555)1.85060759
149Atelectasis (HP:0100750)1.85021152
150Lower limb amyotrophy (HP:0007210)1.84131595
151Asymmetric septal hypertrophy (HP:0001670)1.83912773
152Gastrointestinal dysmotility (HP:0002579)1.83766231
153Hypertriglyceridemia (HP:0002155)1.81985641
154Flat acetabular roof (HP:0003180)1.80950210
155Ragged-red muscle fibers (HP:0003200)1.79843756
156Insomnia (HP:0100785)1.79637018
157Bowing of the arm (HP:0006488)1.78484765
158Bowed forearm bones (HP:0003956)1.78484765
159Aneurysm (HP:0002617)1.78328341
160Gastrointestinal inflammation (HP:0004386)1.78273637
161Rectal prolapse (HP:0002035)1.77084169
162Generalized amyotrophy (HP:0003700)1.76898369
163Cholecystitis (HP:0001082)1.74865436
164Abnormal gallbladder physiology (HP:0012438)1.74865436
165Dilatation of the ascending aorta (HP:0005111)1.74022453
166Nonimmune hydrops fetalis (HP:0001790)1.73871193
167Abnormality of skeletal muscle fiber size (HP:0012084)1.71188305
168Dislocated radial head (HP:0003083)1.70029633
169Aortic regurgitation (HP:0001659)1.69103791
170Trismus (HP:0000211)1.67890142
171Wormian bones (HP:0002645)1.67874753
172Reticulocytosis (HP:0001923)1.67050968
173Metaphyseal cupping (HP:0003021)1.67035614
174Abnormality of the fingertips (HP:0001211)1.66452841
175Natal tooth (HP:0000695)1.64275608
176Syringomyelia (HP:0003396)1.61947428
177Spinal cord lesions (HP:0100561)1.61947428
178Interstitial pulmonary disease (HP:0006530)1.60351650
179Supernumerary nipples (HP:0002558)1.59407929
180Short clavicles (HP:0000894)1.58676354
181Short nail (HP:0001799)1.58311259
182Increased cerebral lipofuscin (HP:0011813)1.58117810
183Abnormality of the radial head (HP:0003995)1.57925363
184Broad metatarsal (HP:0001783)1.57672166

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK6.07823553
2MAPK153.90659732
3DDR23.81148219
4MAP3K63.77821221
5SMG13.36594494
6SIK13.35684903
7MAP3K113.31400350
8UHMK13.05125109
9PRPF4B2.95328612
10ERN12.95168858
11PIM22.87052221
12TYRO32.83774262
13MATK2.56721710
14DAPK12.25233151
15DYRK1B2.15123459
16IRAK32.11255859
17MARK12.08713532
18PINK12.07321095
19PKN22.04568947
20NME21.99203237
21FGR1.96876126
22MAP2K31.94001890
23PHKG11.89684693
24PHKG21.89684693
25MAP4K11.88558912
26PDGFRA1.88203922
27DYRK21.86023055
28MAP3K101.78406636
29CDK71.69868605
30TTN1.67148428
31PRKD21.61241469
32YES11.53849040
33EPHA21.53244393
34FGFR41.50639425
35DYRK31.48619969
36CSK1.47769319
37TNK21.46280315
38LATS21.39795920
39RPS6KC11.37344254
40RPS6KL11.37344254
41BMX1.29672377
42CHEK21.28552719
43RPS6KA61.19009477
44EPHB11.15341624
45RPS6KA21.13504111
46TRIB31.12618663
47TBK11.11580843
48PTK61.11463206
49TAOK21.11052323
50ERBB31.07256854
51PIM11.05223025
52MST1R1.01022912
53ATR0.99583197
54MAP3K30.97343166
55CDC42BPA0.95921532
56IRAK20.95691102
57ARAF0.94198950
58IRAK40.92640368
59NTRK20.91259817
60LMTK20.87762901
61KDR0.86916388
62TYK20.85916940
63GSK3A0.85572046
64PLK10.84511770
65PDPK10.83664208
66RPS6KA10.82926987
67GRK60.82829696
68SIK30.81772106
69MTOR0.81232971
70EPHB20.81062689
71SIK20.80635032
72TLK10.80479503
73PTK20.79873376
74MAP3K10.79446381
75ZAP700.77621148
76MAP3K130.77426144
77CDC70.76917731
78PRKAA10.76093282
79TRPM70.75637869
80TAOK10.75054223
81CDK40.73732806
82CDK60.72861888
83MAP2K20.72508299
84NEK20.69361363
85BLK0.69065835
86HIPK20.66267505
87AURKA0.64302406
88SCYL20.64112869
89MAP3K70.63755561
90MAPK40.61558644
91MAPK110.60531670
92TGFBR10.60142940
93RIPK10.59674439
94RPS6KB20.58519578
95MAP3K80.56498916
96ACVR1B0.55943688
97MARK20.55646259
98CAMKK10.54871437
99CDK20.54764487
100LRRK20.54561847
101JAK30.53789170
102BTK0.52651523
103MAPK120.52093283
104CDK80.51822868
105RPS6KB10.51435262
106MUSK0.50812488
107BCKDK0.50583440
108AKT30.49888756
109CDK120.48148819
110PDK40.47818328
111PDK30.47818328
112RET0.47054437
113PAK20.45872489
114CAMK1D0.45710186
115CDK180.45709926
116CSF1R0.45363280
117CDK11A0.44377073
118HCK0.43483000
119CDK150.43260116
120TESK10.42456162
121BRAF0.41714930
122NTRK10.41338031
123RAF10.40936096
124RIPK40.40911797
125CSNK2A10.40553579
126CDK90.39407303
127PRKD10.39238735
128CHEK10.38919662
129FES0.38658563
130KSR20.37473050
131MAPK90.37067568
132MAP2K60.36779558
133PDK10.36617535
134EEF2K0.36157577
135MAPK70.35537564
136WEE10.34508453
137ATM0.33364814
138MAPKAPK30.32682826
139PAK60.32558776
140CSNK2A20.32180667
141CDK140.32028882
142MAP3K140.31654863
143PRKD30.31636195
144CDK10.31570813
145ALK0.29482098
146CSNK1G10.28879179
147MAPK80.28761330
148EGFR0.27970355
149LYN0.27198112
150MAPK30.26525325
151MAPK140.26337053
152ILK0.25380800
153MAPK10.24772533
154PRKCZ0.24246136
155PAK10.23987734
156MAPKAPK20.23776526
157PAK40.23538024
158PRKCI0.23514081
159TESK20.23119896

Predicted pathways (KEGG)

RankGene SetZ-score
1Base excision repair_Homo sapiens_hsa034104.84760909
2Mismatch repair_Homo sapiens_hsa034304.68673370
3DNA replication_Homo sapiens_hsa030304.58363506
4Fatty acid biosynthesis_Homo sapiens_hsa000613.63607792
5Other glycan degradation_Homo sapiens_hsa005113.06705479
6Spliceosome_Homo sapiens_hsa030402.55328439
7Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.51145893
8Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.31895039
9Nucleotide excision repair_Homo sapiens_hsa034202.29035604
10Sulfur relay system_Homo sapiens_hsa041222.22863642
11mRNA surveillance pathway_Homo sapiens_hsa030152.18639653
12Notch signaling pathway_Homo sapiens_hsa043302.17736540
13RNA transport_Homo sapiens_hsa030132.13948631
14Cyanoamino acid metabolism_Homo sapiens_hsa004602.10851698
15Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.86358694
16Hippo signaling pathway_Homo sapiens_hsa043901.79728263
17Fanconi anemia pathway_Homo sapiens_hsa034601.78576206
18Hedgehog signaling pathway_Homo sapiens_hsa043401.71587519
19Homologous recombination_Homo sapiens_hsa034401.62308181
20Cell cycle_Homo sapiens_hsa041101.58205001
21Pentose phosphate pathway_Homo sapiens_hsa000301.55827721
22Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.55692925
23Ribosome_Homo sapiens_hsa030101.55628771
24Basal cell carcinoma_Homo sapiens_hsa052171.51826641
25Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.51081829
26mTOR signaling pathway_Homo sapiens_hsa041501.49489677
27Circadian rhythm_Homo sapiens_hsa047101.45113666
28Viral myocarditis_Homo sapiens_hsa054161.42169868
29p53 signaling pathway_Homo sapiens_hsa041151.34726629
30Neurotrophin signaling pathway_Homo sapiens_hsa047221.34057101
31Colorectal cancer_Homo sapiens_hsa052101.32188277
32Transcriptional misregulation in cancer_Homo sapiens_hsa052021.29334608
33VEGF signaling pathway_Homo sapiens_hsa043701.23929653
34Wnt signaling pathway_Homo sapiens_hsa043101.22806568
35Osteoclast differentiation_Homo sapiens_hsa043801.18635414
36Oocyte meiosis_Homo sapiens_hsa041141.17462682
37Shigellosis_Homo sapiens_hsa051311.17297936
382-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.12993118
39Adherens junction_Homo sapiens_hsa045201.11760245
40Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.04369999
41Longevity regulating pathway - mammal_Homo sapiens_hsa042111.04367737
42Focal adhesion_Homo sapiens_hsa045101.01665573
43Phospholipase D signaling pathway_Homo sapiens_hsa040721.01319380
44Arginine and proline metabolism_Homo sapiens_hsa003300.99646358
45Bladder cancer_Homo sapiens_hsa052190.99579881
46Hepatitis C_Homo sapiens_hsa051600.99384629
47Lysosome_Homo sapiens_hsa041420.99037835
48Toll-like receptor signaling pathway_Homo sapiens_hsa046200.98459119
49Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.98385293
50Acute myeloid leukemia_Homo sapiens_hsa052210.98119549
51N-Glycan biosynthesis_Homo sapiens_hsa005100.96248440
52TGF-beta signaling pathway_Homo sapiens_hsa043500.94728067
53Pyrimidine metabolism_Homo sapiens_hsa002400.94556062
54Toxoplasmosis_Homo sapiens_hsa051450.93277372
55Inositol phosphate metabolism_Homo sapiens_hsa005620.91015456
56Glioma_Homo sapiens_hsa052140.90976886
57Leukocyte transendothelial migration_Homo sapiens_hsa046700.89783881
58Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.85232130
59RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.85198862
60Biosynthesis of amino acids_Homo sapiens_hsa012300.85006804
61Renal cell carcinoma_Homo sapiens_hsa052110.84842180
62Lysine degradation_Homo sapiens_hsa003100.84769903
63Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.84633073
64Phosphatidylinositol signaling system_Homo sapiens_hsa040700.83717335
65Chronic myeloid leukemia_Homo sapiens_hsa052200.83448291
66TNF signaling pathway_Homo sapiens_hsa046680.82780573
67MicroRNAs in cancer_Homo sapiens_hsa052060.82255445
68One carbon pool by folate_Homo sapiens_hsa006700.81664347
69Endometrial cancer_Homo sapiens_hsa052130.80793934
70Influenza A_Homo sapiens_hsa051640.79511650
71Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.77023957
72Adipocytokine signaling pathway_Homo sapiens_hsa049200.76923529
73Gap junction_Homo sapiens_hsa045400.75039562
74Salmonella infection_Homo sapiens_hsa051320.74761643
75Leishmaniasis_Homo sapiens_hsa051400.74569306
76Prion diseases_Homo sapiens_hsa050200.74551750
77GnRH signaling pathway_Homo sapiens_hsa049120.74321845
78HTLV-I infection_Homo sapiens_hsa051660.74061578
79Insulin resistance_Homo sapiens_hsa049310.73492655
80Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.72541155
81Prolactin signaling pathway_Homo sapiens_hsa049170.70499450
82Epstein-Barr virus infection_Homo sapiens_hsa051690.69784263
83Viral carcinogenesis_Homo sapiens_hsa052030.69011801
84Sphingolipid signaling pathway_Homo sapiens_hsa040710.68899109
85Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.68336353
86Glycerophospholipid metabolism_Homo sapiens_hsa005640.67866076
87Prostate cancer_Homo sapiens_hsa052150.67787977
88Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.67165313
89Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.67111676
90Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.66423089
91Small cell lung cancer_Homo sapiens_hsa052220.66222747
92Tuberculosis_Homo sapiens_hsa051520.66196723
93Amoebiasis_Homo sapiens_hsa051460.65675491
94ErbB signaling pathway_Homo sapiens_hsa040120.63082379
95Basal transcription factors_Homo sapiens_hsa030220.61705294
96T cell receptor signaling pathway_Homo sapiens_hsa046600.60854719
97Primary immunodeficiency_Homo sapiens_hsa053400.60493247
98Thyroid cancer_Homo sapiens_hsa052160.60371458
99Vibrio cholerae infection_Homo sapiens_hsa051100.59876820
100RNA degradation_Homo sapiens_hsa030180.59786411
101Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.59246280
102Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.57604830
103Thyroid hormone signaling pathway_Homo sapiens_hsa049190.57331001
104AMPK signaling pathway_Homo sapiens_hsa041520.57046812
105RNA polymerase_Homo sapiens_hsa030200.56446568
106Axon guidance_Homo sapiens_hsa043600.56384010
107Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.56310911
108ECM-receptor interaction_Homo sapiens_hsa045120.56285149
109Glycosaminoglycan degradation_Homo sapiens_hsa005310.56268159
110Insulin signaling pathway_Homo sapiens_hsa049100.56058555
111Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.55924071
112Central carbon metabolism in cancer_Homo sapiens_hsa052300.55812949
113Legionellosis_Homo sapiens_hsa051340.54633084
114NF-kappa B signaling pathway_Homo sapiens_hsa040640.53847512
115Proteasome_Homo sapiens_hsa030500.52140886
116Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.51774576
117Fructose and mannose metabolism_Homo sapiens_hsa000510.49208199
118Herpes simplex infection_Homo sapiens_hsa051680.49025864
119Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.48989927
120MAPK signaling pathway_Homo sapiens_hsa040100.48440852
121Carbon metabolism_Homo sapiens_hsa012000.48273779
122Rap1 signaling pathway_Homo sapiens_hsa040150.47541342
123Platelet activation_Homo sapiens_hsa046110.47404532
124Folate biosynthesis_Homo sapiens_hsa007900.47079830
125Regulation of actin cytoskeleton_Homo sapiens_hsa048100.45442230
126Tight junction_Homo sapiens_hsa045300.41606399
127Pathways in cancer_Homo sapiens_hsa052000.41365910
128Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.41329914
129Fatty acid metabolism_Homo sapiens_hsa012120.40189233
130Hepatitis B_Homo sapiens_hsa051610.39373501
131Choline metabolism in cancer_Homo sapiens_hsa052310.39150912
132B cell receptor signaling pathway_Homo sapiens_hsa046620.38363827
133Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.37274440
134Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.35661385
135Pancreatic cancer_Homo sapiens_hsa052120.34650042
136Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.32512956
137Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.30482996
138Maturity onset diabetes of the young_Homo sapiens_hsa049500.29716905
139Galactose metabolism_Homo sapiens_hsa000520.29253425
140Non-small cell lung cancer_Homo sapiens_hsa052230.27695364
141Endocytosis_Homo sapiens_hsa041440.27477799
142PI3K-Akt signaling pathway_Homo sapiens_hsa041510.26939633
143Apoptosis_Homo sapiens_hsa042100.26487594
144Proteoglycans in cancer_Homo sapiens_hsa052050.25990001
145Dorso-ventral axis formation_Homo sapiens_hsa043200.22957293
146Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.21508680
147AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.21391205
148Estrogen signaling pathway_Homo sapiens_hsa049150.20905264

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