FAAP20

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)7.85320854
2DNA deamination (GO:0045006)7.28040334
3viral transcription (GO:0019083)6.54530296
4translational termination (GO:0006415)6.29851600
5maturation of SSU-rRNA (GO:0030490)5.86904022
6ribosomal small subunit biogenesis (GO:0042274)5.74805973
7SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.74725843
8translational elongation (GO:0006414)5.73996004
9cotranslational protein targeting to membrane (GO:0006613)5.60239966
10protein targeting to ER (GO:0045047)5.56707859
11protein localization to endoplasmic reticulum (GO:0070972)5.30205617
12establishment of protein localization to endoplasmic reticulum (GO:0072599)5.24747768
13viral life cycle (GO:0019058)5.03267942
14behavioral response to nicotine (GO:0035095)5.00871947
15nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.94967576
16translational initiation (GO:0006413)4.87567703
17cellular protein complex disassembly (GO:0043624)4.83936502
18ribosomal large subunit biogenesis (GO:0042273)4.66622329
19deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.43034483
20protein complex disassembly (GO:0043241)4.33457565
21protein complex biogenesis (GO:0070271)4.25310366
22energy coupled proton transport, down electrochemical gradient (GO:0015985)4.17404063
23ATP synthesis coupled proton transport (GO:0015986)4.17404063
24mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.14854763
25mitochondrial respiratory chain complex I assembly (GO:0032981)4.14854763
26NADH dehydrogenase complex assembly (GO:0010257)4.14854763
27macromolecular complex disassembly (GO:0032984)4.11430352
28telomere maintenance via semi-conservative replication (GO:0032201)4.11006968
29DNA strand elongation involved in DNA replication (GO:0006271)4.10656789
30translation (GO:0006412)4.07027095
31ribonucleoprotein complex biogenesis (GO:0022613)3.96812516
32negative regulation of telomere maintenance (GO:0032205)3.93846753
33proteasome assembly (GO:0043248)3.93152626
34formation of translation preinitiation complex (GO:0001731)3.90955080
35DNA strand elongation (GO:0022616)3.87724876
36GTP biosynthetic process (GO:0006183)3.85681813
37mitochondrial respiratory chain complex assembly (GO:0033108)3.79530102
38nuclear-transcribed mRNA catabolic process (GO:0000956)3.77114749
39protein targeting to membrane (GO:0006612)3.70334652
40mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.64109172
41mRNA catabolic process (GO:0006402)3.57152340
42negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.56943900
43regulation of mitochondrial translation (GO:0070129)3.55298983
44telomere maintenance via recombination (GO:0000722)3.44050345
45UTP biosynthetic process (GO:0006228)3.43189310
46opioid receptor signaling pathway (GO:0038003)3.41633537
47RNA catabolic process (GO:0006401)3.41585986
48rRNA processing (GO:0006364)3.36712004
49DNA unwinding involved in DNA replication (GO:0006268)3.33335994
50nucleobase biosynthetic process (GO:0046112)3.33224436
51cellular component biogenesis (GO:0044085)3.31509433
52purine nucleobase biosynthetic process (GO:0009113)3.29365553
53DNA replication initiation (GO:0006270)3.28949534
54mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.26770057
55antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.26656687
56positive regulation of T cell apoptotic process (GO:0070234)3.26058514
57antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.24772295
58antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.24772295
59rRNA metabolic process (GO:0016072)3.23253542
60glycerophospholipid catabolic process (GO:0046475)3.22183168
61positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.19909731
62negative regulation of ligase activity (GO:0051352)3.18841007
63negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.18841007
64regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.16042703
65ribosome biogenesis (GO:0042254)3.13850398
66protein polyglutamylation (GO:0018095)3.13557411
67electron transport chain (GO:0022900)3.11924297
68purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.10461197
69mitotic recombination (GO:0006312)3.09976304
70UTP metabolic process (GO:0046051)3.09003852
71ubiquinone biosynthetic process (GO:0006744)3.08510136
72iron-sulfur cluster assembly (GO:0016226)3.08296457
73metallo-sulfur cluster assembly (GO:0031163)3.08296457
74respiratory chain complex IV assembly (GO:0008535)3.07516888
75termination of RNA polymerase III transcription (GO:0006386)3.07422430
76transcription elongation from RNA polymerase III promoter (GO:0006385)3.07422430
77antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.06583685
78response to misfolded protein (GO:0051788)3.05255247
79DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.04082356
80pseudouridine synthesis (GO:0001522)3.03698048
81anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.03386816
82respiratory electron transport chain (GO:0022904)3.03160632
83purine nucleoside triphosphate biosynthetic process (GO:0009145)3.01488029
84tRNA modification (GO:0006400)3.00144650
85telomere maintenance via telomere lengthening (GO:0010833)2.99301194
86intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.98851901
87signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.98851901
88regulation of cellular amino acid metabolic process (GO:0006521)2.98755743
89base-excision repair, AP site formation (GO:0006285)2.97486513
90purine-containing compound salvage (GO:0043101)2.97345822
91positive regulation of lymphocyte apoptotic process (GO:0070230)2.96035389
92signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.95942163
93signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.95942163
94signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.95942163
95IMP biosynthetic process (GO:0006188)2.94417452
96ribosome assembly (GO:0042255)2.93693749
97Arp2/3 complex-mediated actin nucleation (GO:0034314)2.92771747
98positive regulation of fatty acid transport (GO:2000193)2.92415177
99positive regulation of prostaglandin secretion (GO:0032308)2.92316148
100phosphatidylglycerol biosynthetic process (GO:0006655)2.91736175
101pteridine-containing compound biosynthetic process (GO:0042559)2.91287561
102mannosylation (GO:0097502)2.90606425
103exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.90196372
104response to interferon-beta (GO:0035456)2.88118979
105L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.87765218
106protein neddylation (GO:0045116)2.86909542
107ATP biosynthetic process (GO:0006754)2.86707318
108chaperone-mediated protein transport (GO:0072321)2.86611771
109antigen processing and presentation via MHC class Ib (GO:0002475)2.85392043
110establishment of integrated proviral latency (GO:0075713)2.85107477
111signal transduction involved in DNA damage checkpoint (GO:0072422)2.85084692
112signal transduction involved in DNA integrity checkpoint (GO:0072401)2.85084692
113pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.85033628
114negative regulation of T cell differentiation in thymus (GO:0033085)2.84553862
115signal transduction involved in cell cycle checkpoint (GO:0072395)2.80505497
116sequestering of actin monomers (GO:0042989)2.79868897
117tooth mineralization (GO:0034505)2.78817221
118ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.77095099
119tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.76948322
120RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.76948322
121ubiquinone metabolic process (GO:0006743)2.76210750
122spliceosomal snRNP assembly (GO:0000387)2.76172677
123substrate-independent telencephalic tangential migration (GO:0021826)2.76018680
124substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.76018680
125positive regulation of icosanoid secretion (GO:0032305)2.75267049
126cardiovascular system development (GO:0072358)2.74849746
127nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.73485361
128folic acid-containing compound biosynthetic process (GO:0009396)2.72190091
129positive regulation of ligase activity (GO:0051351)2.71262226
130positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.70832194
131oxidative phosphorylation (GO:0006119)2.70262427
132antigen processing and presentation of endogenous antigen (GO:0019883)2.69549117
133autophagic vacuole fusion (GO:0000046)2.68845373
134endosome to melanosome transport (GO:0035646)2.68767517
135endosome to pigment granule transport (GO:0043485)2.68767517
136nonmotile primary cilium assembly (GO:0035058)2.68729592
137positive regulation of triglyceride biosynthetic process (GO:0010867)2.68268397
138positive regulation of histone deacetylation (GO:0031065)2.68013694
139synaptic transmission, cholinergic (GO:0007271)2.66845650
140cytochrome complex assembly (GO:0017004)2.66255497
141nucleotide-excision repair, DNA gap filling (GO:0006297)2.65879271
142negative regulation of erythrocyte differentiation (GO:0045647)2.65847641
143hydrogen ion transmembrane transport (GO:1902600)2.65388692
144ribonucleoside triphosphate biosynthetic process (GO:0009201)2.63661592
145tRNA processing (GO:0008033)2.63440168
146protein insertion into membrane (GO:0051205)2.63096418
147axoneme assembly (GO:0035082)2.62997228
148left/right pattern formation (GO:0060972)2.62182859
149preassembly of GPI anchor in ER membrane (GO:0016254)2.62158066
150fucose catabolic process (GO:0019317)2.60837406
151L-fucose metabolic process (GO:0042354)2.60837406
152L-fucose catabolic process (GO:0042355)2.60837406
153guanosine-containing compound biosynthetic process (GO:1901070)2.60153148
154cornea development in camera-type eye (GO:0061303)2.59700409
155maturation of 5.8S rRNA (GO:0000460)2.58627932
156peptidyl-histidine modification (GO:0018202)2.58558782
157establishment of protein localization to membrane (GO:0090150)2.58152409
158ncRNA processing (GO:0034470)2.58096725
159positive regulation of cell cycle arrest (GO:0071158)2.58088420
160tRNA methylation (GO:0030488)2.56909523
161DNA damage response, detection of DNA damage (GO:0042769)2.56555261
162protein-cofactor linkage (GO:0018065)2.56111244
163regulation of nuclear cell cycle DNA replication (GO:0033262)2.55361804
164positive regulation of gastrulation (GO:2000543)2.54188962
165regulation of hydrogen peroxide metabolic process (GO:0010310)2.51048007
166spinal cord development (GO:0021510)2.49981235
167response to pheromone (GO:0019236)2.49290906
168positive regulation of CREB transcription factor activity (GO:0032793)2.48387083
169indolalkylamine metabolic process (GO:0006586)2.47205472
170indole-containing compound catabolic process (GO:0042436)2.47086534
171indolalkylamine catabolic process (GO:0046218)2.47086534
172tryptophan catabolic process (GO:0006569)2.47086534
173kynurenine metabolic process (GO:0070189)2.45964378
174cell migration in hindbrain (GO:0021535)2.45713792

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.77519582
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.34660668
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.05122361
4EZH2_22144423_ChIP-Seq_EOC_Human3.74078227
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.05850587
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.05668040
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.89151066
8MYC_18358816_ChIP-ChIP_MESCs_Mouse2.84054236
9ETS1_20019798_ChIP-Seq_JURKAT_Human2.83006957
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.80962858
11CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.79129069
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.77025043
13SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.65246081
14ELF1_17652178_ChIP-ChIP_JURKAT_Human2.51331532
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.50613926
16SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.48508556
17MYC_19079543_ChIP-ChIP_MESCs_Mouse2.46139363
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.43676329
19MYC_19030024_ChIP-ChIP_MESCs_Mouse2.41403914
20XRN2_22483619_ChIP-Seq_HELA_Human2.40659759
21TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.33199699
22LXR_22292898_ChIP-Seq_THP-1_Human2.25081048
23VDR_23849224_ChIP-Seq_CD4+_Human2.24541271
24P68_20966046_ChIP-Seq_HELA_Human2.24069036
25FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.23328906
26BCL6_27268052_Chip-Seq_Bcells_Human2.14102751
27CTCF_27219007_Chip-Seq_Bcells_Human2.08478585
28ELF1_20517297_ChIP-Seq_JURKAT_Human2.07621327
29EBNA2_21746931_ChIP-Seq_IB4-LCL_Human2.07455698
30E2F1_18555785_ChIP-Seq_MESCs_Mouse2.04269284
31TET1_21451524_ChIP-Seq_MESCs_Mouse2.03660634
32MYC_22102868_ChIP-Seq_BL_Human2.02996227
33GABP_19822575_ChIP-Seq_HepG2_Human2.01896498
34NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.98670469
35DCP1A_22483619_ChIP-Seq_HELA_Human1.97755357
36NELFA_20434984_ChIP-Seq_ESCs_Mouse1.95595035
37CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.92809704
38HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.92459474
39FOXP3_21729870_ChIP-Seq_TREG_Human1.89890476
40YY1_22570637_ChIP-Seq_MALME-3M_Human1.86978447
41EZH2_27294783_Chip-Seq_ESCs_Mouse1.86279231
42CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.85941869
43E2F1_20622854_ChIP-Seq_HELA_Human1.85366941
44SUZ12_27294783_Chip-Seq_ESCs_Mouse1.84986111
45FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.84865379
46ERG_21242973_ChIP-ChIP_JURKAT_Human1.82226272
47CIITA_25753668_ChIP-Seq_RAJI_Human1.80747266
48VDR_21846776_ChIP-Seq_THP-1_Human1.79889540
49SRF_21415370_ChIP-Seq_HL-1_Mouse1.78802477
50RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.78070921
51E2F4_17652178_ChIP-ChIP_JURKAT_Human1.77939783
52RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.77171390
53TTF2_22483619_ChIP-Seq_HELA_Human1.76798713
54PHF8_20622854_ChIP-Seq_HELA_Human1.75709749
55ERG_20887958_ChIP-Seq_HPC-7_Mouse1.75678714
56SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.74804290
57CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.74047441
58THAP11_20581084_ChIP-Seq_MESCs_Mouse1.72515910
59CTCF_20526341_ChIP-Seq_ESCs_Human1.71883767
60NOTCH1_21737748_ChIP-Seq_TLL_Human1.71581156
61SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.71162353
62ZNF274_21170338_ChIP-Seq_K562_Hela1.69024955
63FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.68844996
64HOXB4_20404135_ChIP-ChIP_EML_Mouse1.68825744
65ERA_21632823_ChIP-Seq_H3396_Human1.67140260
66SA1_27219007_Chip-Seq_ERYTHROID_Human1.67045837
67YY1_21170310_ChIP-Seq_MESCs_Mouse1.66746890
68JARID2_20075857_ChIP-Seq_MESCs_Mouse1.65236362
69BCOR_27268052_Chip-Seq_Bcells_Human1.64920820
70SA1_27219007_Chip-Seq_Bcells_Human1.60858966
71FOXP1_21924763_ChIP-Seq_HESCs_Human1.59579753
72EZH2_27304074_Chip-Seq_ESCs_Mouse1.57397255
73SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.56670394
74SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.56192839
75TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.55723207
76IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.55702953
77ZFX_18555785_ChIP-Seq_MESCs_Mouse1.55377414
78IRF8_22096565_ChIP-ChIP_GC-B_Human1.54623131
79CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.54381950
80JARID2_20064375_ChIP-Seq_MESCs_Mouse1.54157702
81SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.53951734
82EED_16625203_ChIP-ChIP_MESCs_Mouse1.51450704
83MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.50153611
84IKZF1_21737484_ChIP-ChIP_HCT116_Human1.50102810
85PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.49629562
86CTCF_26484167_Chip-Seq_Bcells_Mouse1.44982812
87SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.44824792
88SRY_22984422_ChIP-ChIP_TESTIS_Rat1.44211478
89TP53_20018659_ChIP-ChIP_R1E_Mouse1.43424989
90CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.43056046
91SPI1_23547873_ChIP-Seq_NB4_Human1.41753923
92TAF2_19829295_ChIP-Seq_ESCs_Human1.40987029
93EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.40739307
94SCL_19346495_ChIP-Seq_HPC-7_Human1.39991210
95CBX2_27304074_Chip-Seq_ESCs_Mouse1.39772042
96PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.39749120
97POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.39136829
98MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.35998303
99DNAJC2_21179169_ChIP-ChIP_NT2_Human1.35493643
100P300_27268052_Chip-Seq_Bcells_Human1.33420587
101RARB_24833708_ChIP-Seq_LIVER_Mouse1.32685008
102ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.30861082
103PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.30484475
104GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.29888142
105ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.29474694
106TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.29009821
107OCT4_19829295_ChIP-Seq_ESCs_Human1.27738066
108SMC4_20622854_ChIP-Seq_HELA_Human1.27559975
109PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.27046963
110ELK1_19687146_ChIP-ChIP_HELA_Human1.26346140
111REST_21632747_ChIP-Seq_MESCs_Mouse1.26174383
112MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.22823832
113RAC3_21632823_ChIP-Seq_H3396_Human1.22385434
114MYCN_18555785_ChIP-Seq_MESCs_Mouse1.21425726
115STAT4_19710469_ChIP-ChIP_TH1__Mouse1.20743406
116RNF2_27304074_Chip-Seq_ESCs_Mouse1.20442816
117SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.19398608
118DROSHA_22980978_ChIP-Seq_HELA_Human1.17309862
119GATA1_22383799_ChIP-Seq_G1ME_Mouse1.16991144
120NANOG_20526341_ChIP-Seq_ESCs_Human1.16888659
121MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.15457804
122NANOG_18555785_ChIP-Seq_MESCs_Mouse1.15373479
123EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.14963308
124CTCF_21964334_ChIP-Seq_BJAB-B_Human1.13900739
125TP53_22127205_ChIP-Seq_IMR90_Human1.13047017
126STAT1_20625510_ChIP-Seq_HELA_Human1.12725803
127ELK1_22589737_ChIP-Seq_MCF10A_Human1.12496467
128RARA_24833708_ChIP-Seq_LIVER_Mouse1.12441041
129CTCF_27219007_Chip-Seq_ERYTHROID_Human1.11834181
130CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.11661390
131TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.11253077
132KLF4_18555785_ChIP-Seq_MESCs_Mouse1.11032993
133SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.10853562
134KDM5A_27292631_Chip-Seq_BREAST_Human1.10679688
135REST_18959480_ChIP-ChIP_MESCs_Mouse1.10531597
136CTCF_18555785_ChIP-Seq_MESCs_Mouse1.10462750
137BMI1_23680149_ChIP-Seq_NPCS_Mouse1.10186818
138TFEB_21752829_ChIP-Seq_HELA_Human1.09889697
139EZH2_18974828_ChIP-Seq_MESCs_Mouse1.09606791
140RNF2_18974828_ChIP-Seq_MESCs_Mouse1.09606791
141TP63_22573176_ChIP-Seq_HFKS_Human1.09129923
142KDM2B_26808549_Chip-Seq_SUP-B15_Human1.09058942
143THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.08687552
144DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.08194023
145VDR_22108803_ChIP-Seq_LS180_Human1.08076702
146CTCF_21964334_Chip-Seq_Bcells_Human1.07730371
147RAD21_21589869_ChIP-Seq_MESCs_Mouse1.07642734
148EGR1_19374776_ChIP-ChIP_THP-1_Human1.07386068
149MAF_26560356_Chip-Seq_TH1_Human1.07251341
150P53_21459846_ChIP-Seq_SAOS-2_Human1.07154709
151RUNX1_22412390_ChIP-Seq_EML_Mouse1.07143971
152E2F1_21310950_ChIP-Seq_MCF-7_Human1.06681515
153STAT3_1855785_ChIP-Seq_MESCs_Mouse1.06084544
154UTX_26944678_Chip-Seq_JUKART_Human1.05421369
155EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.04819937
156MAF_26560356_Chip-Seq_TH2_Human1.04746137
157SMC3_22415368_ChIP-Seq_MEFs_Mouse1.04447023
158HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.04341447
159CREB1_26743006_Chip-Seq_LNCaP_Human1.04036626
160SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.03933712
161PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.03786220
162BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.00899224
163NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.00454681
164VDR_24763502_ChIP-Seq_THP-1_Human0.99960245
165POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.99081800
166FOXM1_23109430_ChIP-Seq_U2OS_Human0.98743243
167MYB_26560356_Chip-Seq_TH2_Human0.97055450
168YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.95779481
169LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.95562932
170MYB_21317192_ChIP-Seq_ERMYB_Mouse0.95296452
171MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.94916785
172KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.93709424
173CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.93614719
174FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93588218
175SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.92626337
176E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.92108926

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.00109203
2MP0002396_abnormal_hematopoietic_system3.16657811
3MP0004957_abnormal_blastocyst_morpholog2.83290551
4MP0002653_abnormal_ependyma_morphology2.78832081
5MP0003763_abnormal_thymus_physiology2.73615801
6MP0001835_abnormal_antigen_presentation2.63421861
7MP0000685_abnormal_immune_system2.56563246
8MP0005671_abnormal_response_to2.51678001
9MP0003077_abnormal_cell_cycle2.51481647
10MP0003123_paternal_imprinting2.49237807
11MP0002234_abnormal_pharynx_morphology2.44481203
12MP0009379_abnormal_foot_pigmentation2.39093691
13MP0001968_abnormal_touch/_nociception2.36789538
14MP0005646_abnormal_pituitary_gland2.31307729
15MP0004808_abnormal_hematopoietic_stem2.25067044
16MP0009333_abnormal_splenocyte_physiolog2.20895721
17MP0003787_abnormal_imprinting2.20269714
18MP0010094_abnormal_chromosome_stability2.17382250
19MP0008058_abnormal_DNA_repair2.15653861
20MP0004858_abnormal_nervous_system2.11106464
21MP0000490_abnormal_crypts_of2.10791253
22MP0002398_abnormal_bone_marrow2.10489863
23MP0003111_abnormal_nucleus_morphology2.10100602
24MP0009785_altered_susceptibility_to2.07382872
25MP0002837_dystrophic_cardiac_calcinosis2.05355577
26MP0001545_abnormal_hematopoietic_system2.02279647
27MP0005397_hematopoietic_system_phenotyp2.02279647
28MP0002132_abnormal_respiratory_system1.99049734
29MP0001873_stomach_inflammation1.95811607
30MP0006276_abnormal_autonomic_nervous1.94196568
31MP0008007_abnormal_cellular_replicative1.91717496
32MP0001905_abnormal_dopamine_level1.90277227
33MP0006054_spinal_hemorrhage1.89296951
34MP0000689_abnormal_spleen_morphology1.86610682
35MP0005645_abnormal_hypothalamus_physiol1.83713583
36MP0002722_abnormal_immune_system1.83211699
37MP0002736_abnormal_nociception_after1.80333044
38MP0002733_abnormal_thermal_nociception1.79456709
39MP0003186_abnormal_redox_activity1.79248443
40MP0001800_abnormal_humoral_immune1.77503767
41MP0005551_abnormal_eye_electrophysiolog1.73968029
42MP0005025_abnormal_response_to1.72545344
43MP0002420_abnormal_adaptive_immunity1.72210026
44MP0003183_abnormal_peptide_metabolism1.71656189
45MP0002723_abnormal_immune_serum1.70896618
46MP0002102_abnormal_ear_morphology1.70616953
47MP0001819_abnormal_immune_cell1.70174189
48MP0002429_abnormal_blood_cell1.69434675
49MP0000716_abnormal_immune_system1.68036952
50MP0000049_abnormal_middle_ear1.67314756
51MP0003724_increased_susceptibility_to1.67281904
52MP0002822_catalepsy1.65881792
53MP0005000_abnormal_immune_tolerance1.62826446
54MP0001970_abnormal_pain_threshold1.62356805
55MP0004142_abnormal_muscle_tone1.61799845
56MP0001853_heart_inflammation1.61177810
57MP0005464_abnormal_platelet_physiology1.59995129
58MP0003436_decreased_susceptibility_to1.59272405
59MP0003646_muscle_fatigue1.59044336
60MP0003786_premature_aging1.58507011
61MP0002452_abnormal_antigen_presenting1.58238700
62MP0004145_abnormal_muscle_electrophysio1.57749926
63MP0000703_abnormal_thymus_morphology1.57137750
64MP0001986_abnormal_taste_sensitivity1.56846619
65MP0003866_abnormal_defecation1.56527823
66MP0003011_delayed_dark_adaptation1.55165699
67MP0002735_abnormal_chemical_nociception1.53597114
68MP0003878_abnormal_ear_physiology1.51510529
69MP0005377_hearing/vestibular/ear_phenot1.51510529
70MP0002249_abnormal_larynx_morphology1.51200392
71MP0000631_abnormal_neuroendocrine_gland1.50952842
72MP0002019_abnormal_tumor_incidence1.47846710
73MP0009745_abnormal_behavioral_response1.47017949
74MP0002557_abnormal_social/conspecific_i1.46703607
75MP0001502_abnormal_circadian_rhythm1.45797578
76MP0000858_altered_metastatic_potential1.45220419
77MP0000465_gastrointestinal_hemorrhage1.44578503
78MP0008789_abnormal_olfactory_epithelium1.44300025
79MP0008875_abnormal_xenobiotic_pharmacok1.43997960
80MP0008932_abnormal_embryonic_tissue1.41461434
81MP0001188_hyperpigmentation1.41117668
82MP0002166_altered_tumor_susceptibility1.40359317
83MP0002405_respiratory_system_inflammati1.40159436
84MP0002876_abnormal_thyroid_physiology1.38897739
85MP0010155_abnormal_intestine_physiology1.35882564
86MP0005075_abnormal_melanosome_morpholog1.30094566
87MP0008057_abnormal_DNA_replication1.30002567
88MP0002148_abnormal_hypersensitivity_rea1.29547539
89MP0008872_abnormal_physiological_respon1.28972277
90MP0000313_abnormal_cell_death1.28181746
91MP0006072_abnormal_retinal_apoptosis1.25562498
92MP0000678_abnormal_parathyroid_gland1.24532688
93MP0002572_abnormal_emotion/affect_behav1.23927227
94MP0002272_abnormal_nervous_system1.23077568
95MP0010030_abnormal_orbit_morphology1.20889985
96MP0009278_abnormal_bone_marrow1.19685014
97MP0000026_abnormal_inner_ear1.16729847
98MP0003315_abnormal_perineum_morphology1.16641265
99MP0005220_abnormal_exocrine_pancreas1.16213587
100MP0005174_abnormal_tail_pigmentation1.14732734
101MP0003880_abnormal_central_pattern1.14642235
102MP0002163_abnormal_gland_morphology1.14370249
103MP0001845_abnormal_inflammatory_respons1.14185059
104MP0002419_abnormal_innate_immunity1.14015776
105MP0001790_abnormal_immune_system1.13728529
106MP0005387_immune_system_phenotype1.13728529
107MP0006036_abnormal_mitochondrial_physio1.13562184
108MP0004043_abnormal_pH_regulation1.12935236
109MP0002938_white_spotting1.12812316
110MP0002064_seizures1.12184655
111MP0003635_abnormal_synaptic_transmissio1.12168197
112MP0003137_abnormal_impulse_conducting1.12153096
113MP0002933_joint_inflammation1.11520238
114MP0002063_abnormal_learning/memory/cond1.11341358
115MP0000358_abnormal_cell_content/1.11166851
116MP0001485_abnormal_pinna_reflex1.11128196
117MP0002638_abnormal_pupillary_reflex1.10713130
118MP0000350_abnormal_cell_proliferation1.10337333
119MP0002752_abnormal_somatic_nervous1.08861957
120MP0004742_abnormal_vestibular_system1.08035294
121MP0000778_abnormal_nervous_system1.07153323
122MP0009046_muscle_twitch1.06553122
123MP0008469_abnormal_protein_level1.04824593
124MP0002006_tumorigenesis1.04179703
125MP0005394_taste/olfaction_phenotype1.03983247
126MP0005499_abnormal_olfactory_system1.03983247
127MP0003656_abnormal_erythrocyte_physiolo1.02234917
128MP0006292_abnormal_olfactory_placode1.01958032
129MP0005195_abnormal_posterior_eye1.00690095
130MP0003121_genomic_imprinting1.00330343
131MP0001730_embryonic_growth_arrest0.99130333
132MP0000955_abnormal_spinal_cord0.96587705
133MP0005423_abnormal_somatic_nervous0.95356777
134MP0000750_abnormal_muscle_regeneration0.95199070
135MP0005389_reproductive_system_phenotype0.92464972
136MP0000372_irregular_coat_pigmentation0.92181214
137MP0004885_abnormal_endolymph0.91384847
138MP0003122_maternal_imprinting0.90496799
139MP0002928_abnormal_bile_duct0.90467531
140MP0000681_abnormal_thyroid_gland0.90003838
141MP0000538_abnormal_urinary_bladder0.89820599
142MP0004859_abnormal_synaptic_plasticity0.88649401
143MP0010368_abnormal_lymphatic_system0.86819487
144MP0002184_abnormal_innervation0.86127087
145MP0002080_prenatal_lethality0.86013559
146MP0002693_abnormal_pancreas_physiology0.85900134
147MP0001486_abnormal_startle_reflex0.85885480
148MP0003943_abnormal_hepatobiliary_system0.85650781
149MP0003283_abnormal_digestive_organ0.85390821
150MP0003942_abnormal_urinary_system0.84306537
151MP0001529_abnormal_vocalization0.83608463
152MP0003638_abnormal_response/metabolism_0.83416748
153MP0002067_abnormal_sensory_capabilities0.82372527
154MP0000477_abnormal_intestine_morphology0.82217925
155MP0002095_abnormal_skin_pigmentation0.82147657
156MP0003567_abnormal_fetal_cardiomyocyte0.81540126
157MP0003938_abnormal_ear_development0.81225542
158MP0001533_abnormal_skeleton_physiology0.80701185
159MP0001501_abnormal_sleep_pattern0.80183424
160MP0005636_abnormal_mineral_homeostasis0.79941291
161MP0001963_abnormal_hearing_physiology0.79052055
162MP0000230_abnormal_systemic_arterial0.78754346
163MP0010352_gastrointestinal_tract_polyps0.78571699
164MP0005381_digestive/alimentary_phenotyp0.77536072
165MP0002089_abnormal_postnatal_growth/wei0.77357114
166MP0005084_abnormal_gallbladder_morpholo0.76512564
167MP0002160_abnormal_reproductive_system0.76432565
168MP0003806_abnormal_nucleotide_metabolis0.76405783
169MP0002882_abnormal_neuron_morphology0.75616236
170MP0001697_abnormal_embryo_size0.74884452
171MP0002277_abnormal_respiratory_mucosa0.74535290
172MP0008877_abnormal_DNA_methylation0.73906506
173MP0001919_abnormal_reproductive_system0.73862493
174MP0003879_abnormal_hair_cell0.73565407
175MP0003136_yellow_coat_color0.73150544
176MP0005379_endocrine/exocrine_gland_phen0.71977903
177MP0002751_abnormal_autonomic_nervous0.71901106
178MP0004947_skin_inflammation0.71797855
179MP0008995_early_reproductive_senescence0.71327671
180MP0001542_abnormal_bone_strength0.71239933
181MP0001663_abnormal_digestive_system0.69690891
182MP0004147_increased_porphyrin_level0.68296479
183MP0001944_abnormal_pancreas_morphology0.67915918
184MP0004133_heterotaxia0.65909562
185MP0009643_abnormal_urine_homeostasis0.65314886

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)6.19875223
2Abnormal number of erythroid precursors (HP:0012131)5.98421713
3Reticulocytopenia (HP:0001896)5.05631143
4Thrombocytosis (HP:0001894)4.61317244
5Decreased activity of mitochondrial respiratory chain (HP:0008972)4.46919227
6Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.46919227
7Congenital stationary night blindness (HP:0007642)4.07765907
8Abnormal rod and cone electroretinograms (HP:0008323)4.05785302
9Aplastic anemia (HP:0001915)4.00319763
10Pallor (HP:0000980)3.92495770
11Macrocytic anemia (HP:0001972)3.80191341
12Type II lissencephaly (HP:0007260)3.78525349
13Molar tooth sign on MRI (HP:0002419)3.76357983
14Abnormality of midbrain morphology (HP:0002418)3.76357983
15Hepatocellular necrosis (HP:0001404)3.61676035
16Elevated erythrocyte sedimentation rate (HP:0003565)3.47621779
17Hepatic necrosis (HP:0002605)3.39396346
18IgM deficiency (HP:0002850)3.32417721
1911 pairs of ribs (HP:0000878)3.30001005
20Pancreatic cysts (HP:0001737)3.29733825
21Type I transferrin isoform profile (HP:0003642)3.27475794
22Pancreatic fibrosis (HP:0100732)3.14648605
23Aplasia/Hypoplasia of the sacrum (HP:0008517)3.04543939
24Acute encephalopathy (HP:0006846)3.02234627
25Hyperthyroidism (HP:0000836)3.01779066
26Petechiae (HP:0000967)2.99579809
27Nephronophthisis (HP:0000090)2.97998362
28True hermaphroditism (HP:0010459)2.89338460
29Abnormality of the heme biosynthetic pathway (HP:0010472)2.87763519
30Microretrognathia (HP:0000308)2.87191691
31Poikiloderma (HP:0001029)2.83094016
32Recurrent bronchitis (HP:0002837)2.82940295
33Carpal bone hypoplasia (HP:0001498)2.82627243
34Pendular nystagmus (HP:0012043)2.78203465
35Colon cancer (HP:0003003)2.77426842
36Mitochondrial inheritance (HP:0001427)2.72410270
37Muscle fiber atrophy (HP:0100295)2.71581367
38Rib fusion (HP:0000902)2.66558467
39Increased intramyocellular lipid droplets (HP:0012240)2.63693233
40Exertional dyspnea (HP:0002875)2.62055692
41Oral leukoplakia (HP:0002745)2.61914733
42Chronic otitis media (HP:0000389)2.60304132
43Increased serum lactate (HP:0002151)2.58999735
44Prolonged bleeding time (HP:0003010)2.58176470
45Increased hepatocellular lipid droplets (HP:0006565)2.58174137
46Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.57209773
47Cerebellar dysplasia (HP:0007033)2.56967508
48Sclerocornea (HP:0000647)2.56817832
49Poor head control (HP:0002421)2.56137172
50Cystic liver disease (HP:0006706)2.54840557
51Progressive macrocephaly (HP:0004481)2.54650281
52Abnormal protein N-linked glycosylation (HP:0012347)2.51841636
53Abnormal protein glycosylation (HP:0012346)2.51841636
54Abnormal glycosylation (HP:0012345)2.51841636
55Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.51841636
56Lipid accumulation in hepatocytes (HP:0006561)2.49619287
57Beaking of vertebral bodies (HP:0004568)2.47535991
58Pancytopenia (HP:0001876)2.46652529
59Attenuation of retinal blood vessels (HP:0007843)2.46647405
60Increased muscle lipid content (HP:0009058)2.46049454
61Aplasia/Hypoplasia of the patella (HP:0006498)2.44861705
62Progressive muscle weakness (HP:0003323)2.43106953
63Increased CSF lactate (HP:0002490)2.38794426
64Mesangial abnormality (HP:0001966)2.37860048
65Medial flaring of the eyebrow (HP:0010747)2.37750230
66Type 2 muscle fiber atrophy (HP:0003554)2.35309621
67Abnormality of the renal medulla (HP:0100957)2.34762537
68Reduced antithrombin III activity (HP:0001976)2.33535880
69Patellar aplasia (HP:0006443)2.33474603
70Hypothermia (HP:0002045)2.33472483
71Severe muscular hypotonia (HP:0006829)2.32674798
72Aplasia/Hypoplasia of the spleen (HP:0010451)2.28034108
73Abnormality of T cell physiology (HP:0011840)2.25839134
74Lissencephaly (HP:0001339)2.25350064
75Anencephaly (HP:0002323)2.25259036
76Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.22454879
77Concave nail (HP:0001598)2.21174840
78Ragged-red muscle fibers (HP:0003200)2.20982782
79Myositis (HP:0100614)2.20767865
80Generalized aminoaciduria (HP:0002909)2.20075688
81Microvesicular hepatic steatosis (HP:0001414)2.19936743
82Abnormality of T cells (HP:0002843)2.19560059
83Abnormal mitochondria in muscle tissue (HP:0008316)2.19420571
84Increased neuronal autofluorescent lipopigment (HP:0002074)2.17092852
85Lactic acidosis (HP:0003128)2.16168601
86Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.16121303
87Optic disc pallor (HP:0000543)2.13808397
88Myokymia (HP:0002411)2.13754685
89Retinal dysplasia (HP:0007973)2.12745122
90Polydipsia (HP:0001959)2.11751830
91Abnormal drinking behavior (HP:0030082)2.11751830
92Impaired platelet aggregation (HP:0003540)2.10815156
93Abnormal platelet function (HP:0011869)2.10815156
94Asplenia (HP:0001746)2.09246533
95Truncus arteriosus (HP:0001660)2.07297886
96Entropion (HP:0000621)2.07260720
97Bulbous nose (HP:0000414)2.06185028
98Occipital encephalocele (HP:0002085)2.05275125
99Abnormality of the renal cortex (HP:0011035)2.03982645
100Pachygyria (HP:0001302)2.03163736
101Progressive microcephaly (HP:0000253)2.03133807
102Epistaxis (HP:0000421)2.01267073
103Testicular atrophy (HP:0000029)2.00445545
104Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.00417616
105Tubular atrophy (HP:0000092)2.00154404
106Emotional lability (HP:0000712)1.98720303
107Flat capital femoral epiphysis (HP:0003370)1.97827313
108Birth length less than 3rd percentile (HP:0003561)1.96442754
109Polyphagia (HP:0002591)1.96423059
110Hypoplasia of the pons (HP:0012110)1.96174725
111Abolished electroretinogram (ERG) (HP:0000550)1.95494118
112Abnormality of the aortic arch (HP:0012303)1.94284247
113Late onset (HP:0003584)1.93941155
114Multiple enchondromatosis (HP:0005701)1.93446152
115Cerebral hypomyelination (HP:0006808)1.92765597
116Bony spicule pigmentary retinopathy (HP:0007737)1.92388670
117Decreased central vision (HP:0007663)1.92208202
118Cleft eyelid (HP:0000625)1.92194494
119Abnormality of reticulocytes (HP:0004312)1.92132806
120Rough bone trabeculation (HP:0100670)1.91625680
121Lymphoma (HP:0002665)1.90804104
122Myelodysplasia (HP:0002863)1.90604283
123Decreased electroretinogram (ERG) amplitude (HP:0000654)1.90338654
124IgG deficiency (HP:0004315)1.90231221
125Severe visual impairment (HP:0001141)1.89602128
126Lymphopenia (HP:0001888)1.88138150
127Acute necrotizing encephalopathy (HP:0006965)1.87674152
128Septo-optic dysplasia (HP:0100842)1.86193233
129Abnormality of cells of the lymphoid lineage (HP:0012140)1.84789623
130Keratoconus (HP:0000563)1.84174755
131Increased corneal curvature (HP:0100692)1.84174755
132Gait imbalance (HP:0002141)1.80343102
133Absent thumb (HP:0009777)1.80017770
1343-Methylglutaconic aciduria (HP:0003535)1.76852529
135Dicarboxylic aciduria (HP:0003215)1.76354466
136Abnormality of dicarboxylic acid metabolism (HP:0010995)1.76354466
137Degeneration of anterior horn cells (HP:0002398)1.75803969
138Abnormality of the anterior horn cell (HP:0006802)1.75803969
139Respiratory difficulties (HP:0002880)1.73987468
140Visual hallucinations (HP:0002367)1.72822180
141Breast hypoplasia (HP:0003187)1.72251102
142Bile duct proliferation (HP:0001408)1.71722839
143Abnormal biliary tract physiology (HP:0012439)1.71722839
144Purpura (HP:0000979)1.71231866
145Absent rod-and cone-mediated responses on ERG (HP:0007688)1.69848682
146Depressed nasal ridge (HP:0000457)1.68363367
147Clumsiness (HP:0002312)1.68161571
148Vertebral compression fractures (HP:0002953)1.68111657
149Agitation (HP:0000713)1.67773830
150Acute lymphatic leukemia (HP:0006721)1.67203895
151Renal Fanconi syndrome (HP:0001994)1.66521437
152Congenital hepatic fibrosis (HP:0002612)1.66492787
153Large eyes (HP:0001090)1.64686796
154Abnormality of the nasal mucosa (HP:0000433)1.64232571
155Prolonged QT interval (HP:0001657)1.63959848
156Respiratory failure (HP:0002878)1.63670414
157Secondary amenorrhea (HP:0000869)1.63510575
158Renal dysplasia (HP:0000110)1.63095356
159Cerebral edema (HP:0002181)1.63021818
160Abnormality of the pons (HP:0007361)1.62999777
161Broad distal phalanx of finger (HP:0009836)1.62485849
162Cellular immunodeficiency (HP:0005374)1.62062113
163Exercise intolerance (HP:0003546)1.61928087
164Biconcave vertebral bodies (HP:0004586)1.61254347
165CNS demyelination (HP:0007305)1.61236674
166Interstitial pulmonary disease (HP:0006530)1.60039146
167Trismus (HP:0000211)1.59927032
168Amaurosis fugax (HP:0100576)1.59353806
169Vacuolated lymphocytes (HP:0001922)1.58078664
170Selective tooth agenesis (HP:0001592)1.57506679

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME23.89890326
2STK163.04981452
3MAP4K12.99408421
4BUB12.86473073
5VRK22.79310219
6PIM22.71825807
7ADRBK22.67625755
8TAOK32.64087303
9TESK22.61327831
10MAP3K122.49754061
11MAP2K32.27506915
12WEE12.24498533
13KIT2.20510117
14TGFBR12.17736415
15PRKD22.17244273
16KDR2.12208014
17DYRK32.09987451
18FRK2.05236653
19WNK42.04641877
20GRK12.02386368
21PRKD31.91957127
22CDK191.90950363
23ACVR1B1.87555915
24BLK1.87485347
25ARAF1.81801066
26ZAP701.80501830
27BCKDK1.73224057
28LRRK21.62929848
29PINK11.62685481
30MAP3K111.62484092
31TNK21.61149585
32MAP4K21.60730639
33MAP3K31.60663076
34DYRK21.60249972
35MAPK151.59171961
36BRSK21.56478601
37JAK31.55681070
38BTK1.54804121
39TLK11.54746499
40FLT31.54062314
41TEC1.53075151
42SIK21.51939380
43TAOK11.44290141
44VRK11.43832383
45SCYL21.42618894
46NUAK11.40855334
47MAPKAPK31.39758963
48RPS6KA41.39079408
49TAOK21.37914535
50TESK11.37445058
51DAPK21.34099356
52CDC71.32816393
53BRAF1.28754984
54EIF2AK11.26445669
55EPHB21.24062699
56ZAK1.22386577
57ILK1.18862327
58ADRBK11.18559238
59PAK41.17497423
60RPS6KB21.17368832
61EIF2AK31.15118871
62MYLK1.11642315
63SYK1.10984058
64MAPK131.08708644
65PASK1.08099025
66TBK11.05404483
67INSRR1.05100747
68TIE11.04426080
69CDK81.03588301
70ERN11.02581473
71BRSK11.02561253
72ABL21.00915335
73TSSK60.99672169
74PRKCI0.97886826
75MAP2K70.94071763
76DAPK10.93851394
77PRKCH0.91719110
78TXK0.91270109
79TYK20.90835774
80CCNB10.88069023
81MARK20.88012442
82TRIB30.87639069
83CSNK1G30.85204350
84MAP2K20.85075943
85MARK10.83398786
86CAMK10.83229083
87STK110.83006836
88NEK20.81533645
89CSF1R0.80904056
90CDK70.78316898
91MAP2K60.76920843
92PRKCG0.76642519
93NTRK20.75795292
94PKN10.75488345
95RPS6KA50.75385506
96IKBKE0.75368538
97IRAK40.75246087
98SIK30.75185306
99WNK30.74256792
100CAMKK20.72872189
101MATK0.72193670
102CSNK1G20.70768779
103NLK0.69952947
104PLK10.68968089
105AURKB0.68842625
106HIPK20.68803981
107RPS6KA20.68239583
108IRAK30.65840849
109CAMKK10.64911398
110MAPKAPK50.64064696
111MAP3K80.64003600
112TYRO30.62668551
113SRPK10.62615230
114RAF10.62425586
115PHKG20.61906716
116PHKG10.61906716
117PRKCZ0.61479149
118LIMK10.61124073
119SIK10.60154256
120PIM10.58906252
121GRK60.58629453
122TGFBR20.58281925
123AURKA0.57677178
124ATR0.56081228
125DYRK1B0.54858463
126EEF2K0.54399088
127BMPR1B0.54077938
128LYN0.53242425
129IKBKB0.53120967
130MUSK0.53050061
131CSNK1A1L0.52618099
132CSNK1G10.52216819
133PKN20.52103408
134RPS6KL10.50351306
135RPS6KC10.50351306
136PRKG20.49969162
137NME10.48632626
138MAP2K40.48537363
139MAP3K70.47986802
140ICK0.47979889
141PAK10.47933259
142MAP3K100.47591828
143CSNK2A10.47065821
144PRKCQ0.46934613
145RPS6KA60.46873728
146LCK0.46739670
147ITK0.45831626
148PLK40.45099820
149STK100.44532211
150MKNK10.42982297
151CDK40.41597424
152EPHA40.40727511
153AKT30.40044147
154CSNK2A20.39491332
155PRKACA0.39208032
156PAK30.36526669
157DAPK30.33533959

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.84377457
2DNA replication_Homo sapiens_hsa030304.59945777
3Proteasome_Homo sapiens_hsa030503.93108771
4RNA polymerase_Homo sapiens_hsa030203.20608078
5Mismatch repair_Homo sapiens_hsa034303.14924499
6Pyrimidine metabolism_Homo sapiens_hsa002402.72425222
7Base excision repair_Homo sapiens_hsa034102.70158291
8Spliceosome_Homo sapiens_hsa030402.62541606
9Homologous recombination_Homo sapiens_hsa034402.48035235
10Phototransduction_Homo sapiens_hsa047442.46047875
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.25413257
12alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.24087902
13Nucleotide excision repair_Homo sapiens_hsa034202.21352944
14Cardiac muscle contraction_Homo sapiens_hsa042602.14274736
15Linoleic acid metabolism_Homo sapiens_hsa005912.00064360
16Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.93884750
17Protein export_Homo sapiens_hsa030601.90154690
18RNA transport_Homo sapiens_hsa030131.76868596
19Sulfur relay system_Homo sapiens_hsa041221.72093323
20Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.71733859
21Folate biosynthesis_Homo sapiens_hsa007901.65823701
22Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.65074381
23Primary immunodeficiency_Homo sapiens_hsa053401.62158351
24Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.58346676
25Cell cycle_Homo sapiens_hsa041101.56291732
26Parkinsons disease_Homo sapiens_hsa050121.54909928
27Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.46264184
28One carbon pool by folate_Homo sapiens_hsa006701.41821607
29RNA degradation_Homo sapiens_hsa030181.40637954
30Ether lipid metabolism_Homo sapiens_hsa005651.40581641
31Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.35901112
32Purine metabolism_Homo sapiens_hsa002301.32187994
33Nicotine addiction_Homo sapiens_hsa050331.31184261
34Collecting duct acid secretion_Homo sapiens_hsa049661.30132229
35Oxidative phosphorylation_Homo sapiens_hsa001901.25743123
36Antigen processing and presentation_Homo sapiens_hsa046121.23712003
37Non-homologous end-joining_Homo sapiens_hsa034501.23180004
38Arachidonic acid metabolism_Homo sapiens_hsa005901.21393118
39Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.17839568
40Thyroid cancer_Homo sapiens_hsa052161.17125006
41N-Glycan biosynthesis_Homo sapiens_hsa005101.15952840
42p53 signaling pathway_Homo sapiens_hsa041151.12343856
43Fanconi anemia pathway_Homo sapiens_hsa034601.10838765
44Nitrogen metabolism_Homo sapiens_hsa009101.07727851
45Galactose metabolism_Homo sapiens_hsa000521.05540151
46Pentose phosphate pathway_Homo sapiens_hsa000301.03705394
47Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.03566981
48Morphine addiction_Homo sapiens_hsa050321.03061882
49Tryptophan metabolism_Homo sapiens_hsa003801.02047799
50Huntingtons disease_Homo sapiens_hsa050161.01483974
51Drug metabolism - other enzymes_Homo sapiens_hsa009830.98679349
52Basal transcription factors_Homo sapiens_hsa030220.97074448
53Epstein-Barr virus infection_Homo sapiens_hsa051690.95297853
54Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.94986372
55Butanoate metabolism_Homo sapiens_hsa006500.92400949
56Herpes simplex infection_Homo sapiens_hsa051680.92263077
57Basal cell carcinoma_Homo sapiens_hsa052170.90775813
58Synaptic vesicle cycle_Homo sapiens_hsa047210.90560419
59Peroxisome_Homo sapiens_hsa041460.89665372
60Hematopoietic cell lineage_Homo sapiens_hsa046400.84552839
61Other glycan degradation_Homo sapiens_hsa005110.83141191
62Selenocompound metabolism_Homo sapiens_hsa004500.82676867
63Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.80002839
64Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.79912437
65Leishmaniasis_Homo sapiens_hsa051400.78835404
66Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.77069277
67Measles_Homo sapiens_hsa051620.76737924
68Olfactory transduction_Homo sapiens_hsa047400.75874504
69RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.75468140
70Notch signaling pathway_Homo sapiens_hsa043300.73609462
71Legionellosis_Homo sapiens_hsa051340.73565087
72Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.73178008
73Sulfur metabolism_Homo sapiens_hsa009200.72863421
74Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.72127908
75Shigellosis_Homo sapiens_hsa051310.71443523
76Glycerophospholipid metabolism_Homo sapiens_hsa005640.70453148
77Cyanoamino acid metabolism_Homo sapiens_hsa004600.68982923
78Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.68927828
79Insulin secretion_Homo sapiens_hsa049110.68827856
80Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.68719011
81Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.67461750
82Intestinal immune network for IgA production_Homo sapiens_hsa046720.67135737
83Cysteine and methionine metabolism_Homo sapiens_hsa002700.66950251
84Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.65831878
85Hedgehog signaling pathway_Homo sapiens_hsa043400.65466932
86Acute myeloid leukemia_Homo sapiens_hsa052210.64901320
87Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.63317914
88Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.62715876
89Glutamatergic synapse_Homo sapiens_hsa047240.62032288
90Alzheimers disease_Homo sapiens_hsa050100.61968882
91Circadian entrainment_Homo sapiens_hsa047130.61221756
92Glycerolipid metabolism_Homo sapiens_hsa005610.56219198
93Glutathione metabolism_Homo sapiens_hsa004800.56177784
94SNARE interactions in vesicular transport_Homo sapiens_hsa041300.54955555
95Serotonergic synapse_Homo sapiens_hsa047260.53977101
96Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.52329141
97Regulation of autophagy_Homo sapiens_hsa041400.51772940
98Ovarian steroidogenesis_Homo sapiens_hsa049130.50958026
99Cocaine addiction_Homo sapiens_hsa050300.50415872
100Chemical carcinogenesis_Homo sapiens_hsa052040.49701770
101Fat digestion and absorption_Homo sapiens_hsa049750.48907741
102HTLV-I infection_Homo sapiens_hsa051660.48610735
103Maturity onset diabetes of the young_Homo sapiens_hsa049500.47645908
104Biosynthesis of amino acids_Homo sapiens_hsa012300.47093833
105GABAergic synapse_Homo sapiens_hsa047270.47014754
106Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.46014505
107Hepatitis B_Homo sapiens_hsa051610.44888228
108B cell receptor signaling pathway_Homo sapiens_hsa046620.44807068
109Dopaminergic synapse_Homo sapiens_hsa047280.44802567
110Fructose and mannose metabolism_Homo sapiens_hsa000510.44730438
111Apoptosis_Homo sapiens_hsa042100.44585946
112Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.44414029
113Jak-STAT signaling pathway_Homo sapiens_hsa046300.43918087
114Autoimmune thyroid disease_Homo sapiens_hsa053200.43448753
115mRNA surveillance pathway_Homo sapiens_hsa030150.43296399
116Carbon metabolism_Homo sapiens_hsa012000.42432646
117Taste transduction_Homo sapiens_hsa047420.42325593
118Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.41646554
119Calcium signaling pathway_Homo sapiens_hsa040200.41484234
120Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.41204831
121Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.40420375
122NF-kappa B signaling pathway_Homo sapiens_hsa040640.39863805
123Rheumatoid arthritis_Homo sapiens_hsa053230.38639971
124Glycosaminoglycan degradation_Homo sapiens_hsa005310.38618072
125ABC transporters_Homo sapiens_hsa020100.37704499
126Pertussis_Homo sapiens_hsa051330.37489289
127Lysosome_Homo sapiens_hsa041420.37419929
128T cell receptor signaling pathway_Homo sapiens_hsa046600.37080947
129Viral carcinogenesis_Homo sapiens_hsa052030.36399249
130Influenza A_Homo sapiens_hsa051640.35505975
131Tyrosine metabolism_Homo sapiens_hsa003500.34917016
132Steroid hormone biosynthesis_Homo sapiens_hsa001400.34910685
133MAPK signaling pathway_Homo sapiens_hsa040100.34593862
134Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.34196858
135VEGF signaling pathway_Homo sapiens_hsa043700.34108122
136Metabolic pathways_Homo sapiens_hsa011000.33924066
137Neurotrophin signaling pathway_Homo sapiens_hsa047220.33854165
138Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.33678606
139Axon guidance_Homo sapiens_hsa043600.33438212
140Transcriptional misregulation in cancer_Homo sapiens_hsa052020.33298587
141Colorectal cancer_Homo sapiens_hsa052100.33241148
142Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.32370738
143Allograft rejection_Homo sapiens_hsa053300.31970607
144Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.30206862
145Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.30029943
146Vascular smooth muscle contraction_Homo sapiens_hsa042700.29727482
147Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.29406724
148Asthma_Homo sapiens_hsa053100.28656308
149Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.28540846
150Platelet activation_Homo sapiens_hsa046110.26770974
151Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.26276001
152Primary bile acid biosynthesis_Homo sapiens_hsa001200.25743014
153Chronic myeloid leukemia_Homo sapiens_hsa052200.25357835
154Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.24995218
155Cholinergic synapse_Homo sapiens_hsa047250.24720480
156Graft-versus-host disease_Homo sapiens_hsa053320.24170705
157Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.23900933
158Systemic lupus erythematosus_Homo sapiens_hsa053220.23865612
159Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.23448874
160Type I diabetes mellitus_Homo sapiens_hsa049400.22926646
161Pentose and glucuronate interconversions_Homo sapiens_hsa000400.20977316
162Salmonella infection_Homo sapiens_hsa051320.20415974

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