FAAP24

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: FAAP24 is a component of the Fanconi anemia (FA) core complex (see MIM 227650), which plays a crucial role in DNA damage response (Ciccia et al., 2007 [PubMed 17289582]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)5.31105513
2behavioral response to nicotine (GO:0035095)5.20156806
3maturation of SSU-rRNA (GO:0030490)4.83079600
4maturation of 5.8S rRNA (GO:0000460)4.76773317
5telomere maintenance via semi-conservative replication (GO:0032201)4.70983220
6DNA strand elongation involved in DNA replication (GO:0006271)4.56509195
7DNA replication checkpoint (GO:0000076)4.49991316
8pseudouridine synthesis (GO:0001522)4.39154139
9telomere maintenance via recombination (GO:0000722)4.36190478
10DNA strand elongation (GO:0022616)4.35299841
11DNA replication initiation (GO:0006270)4.29731418
12mitotic metaphase plate congression (GO:0007080)4.29375427
13CENP-A containing nucleosome assembly (GO:0034080)4.21891980
14DNA deamination (GO:0045006)4.13795210
15regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)4.13343432
16ribosomal small subunit assembly (GO:0000028)4.11457765
17tRNA methylation (GO:0030488)4.07370743
18fucose catabolic process (GO:0019317)4.05701559
19L-fucose metabolic process (GO:0042354)4.05701559
20L-fucose catabolic process (GO:0042355)4.05701559
21protein-cofactor linkage (GO:0018065)4.03765867
22chromatin remodeling at centromere (GO:0031055)4.00934973
23mitotic recombination (GO:0006312)4.00517747
24ribosomal large subunit biogenesis (GO:0042273)3.85014132
25viral transcription (GO:0019083)3.81185356
26protein localization to kinetochore (GO:0034501)3.80573119
27NADH dehydrogenase complex assembly (GO:0010257)3.80279592
28mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.80279592
29mitochondrial respiratory chain complex I assembly (GO:0032981)3.80279592
30ribosomal small subunit biogenesis (GO:0042274)3.78817521
31kinetochore organization (GO:0051383)3.77902831
32negative regulation of telomere maintenance (GO:0032205)3.77030037
33translational termination (GO:0006415)3.76968481
34rRNA catabolic process (GO:0016075)3.76427764
35proteasome assembly (GO:0043248)3.76418541
36platelet dense granule organization (GO:0060155)3.76415452
37DNA replication-independent nucleosome assembly (GO:0006336)3.76243283
38DNA replication-independent nucleosome organization (GO:0034724)3.76243283
39protein complex biogenesis (GO:0070271)3.72693031
40response to pheromone (GO:0019236)3.72271018
41protein localization to chromosome, centromeric region (GO:0071459)3.72068638
42nucleobase biosynthetic process (GO:0046112)3.71907574
43water-soluble vitamin biosynthetic process (GO:0042364)3.65951682
44telomere maintenance via telomere lengthening (GO:0010833)3.65448208
45metaphase plate congression (GO:0051310)3.64347931
46ribonucleoprotein complex biogenesis (GO:0022613)3.61114345
47kynurenine metabolic process (GO:0070189)3.60215104
48ribosome assembly (GO:0042255)3.59112217
49nucleotide-excision repair, DNA gap filling (GO:0006297)3.58780413
50tryptophan catabolic process (GO:0006569)3.54043933
51indole-containing compound catabolic process (GO:0042436)3.54043933
52indolalkylamine catabolic process (GO:0046218)3.54043933
53mitochondrial respiratory chain complex assembly (GO:0033108)3.54028549
54ribosome biogenesis (GO:0042254)3.53176800
55mitotic nuclear envelope disassembly (GO:0007077)3.52991334
56kinetochore assembly (GO:0051382)3.50611082
57indolalkylamine metabolic process (GO:0006586)3.47938083
58translational initiation (GO:0006413)3.46070344
59rRNA processing (GO:0006364)3.46033021
60mitotic sister chromatid segregation (GO:0000070)3.44942510
61regulation of spindle organization (GO:0090224)3.40774443
62protein import into peroxisome matrix (GO:0016558)3.40627009
63attachment of spindle microtubules to kinetochore (GO:0008608)3.39681465
64histone exchange (GO:0043486)3.39464050
65spliceosomal snRNP assembly (GO:0000387)3.38558742
66purine nucleobase biosynthetic process (GO:0009113)3.38393587
67translational elongation (GO:0006414)3.37684975
68protoporphyrinogen IX biosynthetic process (GO:0006782)3.36314319
69folic acid-containing compound biosynthetic process (GO:0009396)3.35046906
70SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.34860698
71termination of RNA polymerase III transcription (GO:0006386)3.34529716
72transcription elongation from RNA polymerase III promoter (GO:0006385)3.34529716
73establishment of chromosome localization (GO:0051303)3.34361933
74rRNA metabolic process (GO:0016072)3.34003900
75cotranslational protein targeting to membrane (GO:0006613)3.31623892
76deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.29745642
77mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.28020333
78protein targeting to ER (GO:0045047)3.26859111
79L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.24971666
80detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.23988727
81replication fork processing (GO:0031297)3.22957220
82piRNA metabolic process (GO:0034587)3.22526832
83membrane disassembly (GO:0030397)3.21875656
84nuclear envelope disassembly (GO:0051081)3.21875656
85sulfation (GO:0051923)3.21773490
86nucleotide transmembrane transport (GO:1901679)3.21384544
87anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.20804190
88cullin deneddylation (GO:0010388)3.19935935
89cellular ketone body metabolic process (GO:0046950)3.19565588
90nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.18175772
91RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.16175874
92tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.16175874
93RNA methylation (GO:0001510)3.14333571
94respiratory chain complex IV assembly (GO:0008535)3.14051826
95formation of translation preinitiation complex (GO:0001731)3.11369908
96protein localization to endoplasmic reticulum (GO:0070972)3.10581819
97spliceosomal complex assembly (GO:0000245)3.10348063
98protein K6-linked ubiquitination (GO:0085020)3.09523811
99establishment of protein localization to endoplasmic reticulum (GO:0072599)3.09252133
100negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.09092965
101RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.09035554
102mitotic chromosome condensation (GO:0007076)3.08515423
103regulation of centriole replication (GO:0046599)3.08435543
104protein deneddylation (GO:0000338)3.07869100
105preassembly of GPI anchor in ER membrane (GO:0016254)3.06810238
106regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.06440339
107negative regulation of mast cell activation (GO:0033004)3.06369094
108regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.06219216
109rRNA modification (GO:0000154)3.05065164
110IMP biosynthetic process (GO:0006188)3.03935230
111tryptophan metabolic process (GO:0006568)3.03762493
112DNA unwinding involved in DNA replication (GO:0006268)3.03598138
113cellular protein complex disassembly (GO:0043624)3.03595198
114mannosylation (GO:0097502)3.03463563
115protoporphyrinogen IX metabolic process (GO:0046501)3.01312920
116DNA replication-dependent nucleosome assembly (GO:0006335)3.00930052
117DNA replication-dependent nucleosome organization (GO:0034723)3.00930052
118positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.00625755
119transcription-coupled nucleotide-excision repair (GO:0006283)3.00177300
120DNA double-strand break processing (GO:0000729)2.99221097
121epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.98241003
122regulation of double-strand break repair via homologous recombination (GO:0010569)2.97601761
123reciprocal meiotic recombination (GO:0007131)2.97301012
124reciprocal DNA recombination (GO:0035825)2.97301012
125DNA ligation (GO:0006266)2.97046705
126recombinational repair (GO:0000725)2.96405976
127sister chromatid segregation (GO:0000819)2.95976357
128translation (GO:0006412)2.95178086
129DNA synthesis involved in DNA repair (GO:0000731)2.93996399
130double-strand break repair via homologous recombination (GO:0000724)2.93779409
131regulation of spindle checkpoint (GO:0090231)2.93063676
132ketone body metabolic process (GO:1902224)2.92872215
133viral life cycle (GO:0019058)2.90650670
134exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.89720627
135nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.89651474
136detection of light stimulus involved in visual perception (GO:0050908)2.89499787
137detection of light stimulus involved in sensory perception (GO:0050962)2.89499787
138regulation of centrosome cycle (GO:0046605)2.88060776
139cytochrome complex assembly (GO:0017004)2.87412293
140chromosome segregation (GO:0007059)2.86064276
141maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.85779899
142telomere organization (GO:0032200)2.85730672
143negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.85274503
144negative regulation of ligase activity (GO:0051352)2.85274503
145spindle checkpoint (GO:0031577)2.84546207
146telomere maintenance (GO:0000723)2.83646151
147cell cycle G1/S phase transition (GO:0044843)2.83030619
148G1/S transition of mitotic cell cycle (GO:0000082)2.83030619
149positive regulation of megakaryocyte differentiation (GO:0045654)2.82291282
150protein polyglutamylation (GO:0018095)2.80204483
151DNA methylation involved in gamete generation (GO:0043046)2.77219060
152regulation of nuclear cell cycle DNA replication (GO:0033262)2.76361397
153energy coupled proton transport, down electrochemical gradient (GO:0015985)2.75751933
154ATP synthesis coupled proton transport (GO:0015986)2.75751933
155positive regulation of defense response to virus by host (GO:0002230)2.75159646
156intracellular protein transmembrane import (GO:0044743)2.75024348
157axoneme assembly (GO:0035082)2.74403306
158male meiosis I (GO:0007141)2.73519758
159epithelial cilium movement (GO:0003351)2.72269308
160tRNA processing (GO:0008033)2.70502930
161synapsis (GO:0007129)2.69926583
162meiotic chromosome segregation (GO:0045132)2.69502295
163adaptation of signaling pathway (GO:0023058)2.68746753
164ubiquinone biosynthetic process (GO:0006744)2.66443612
165indole-containing compound metabolic process (GO:0042430)2.65930305
166regulation of cilium movement (GO:0003352)2.65438627
167protein K11-linked deubiquitination (GO:0035871)2.64786118
168dopamine transport (GO:0015872)2.63546925
169positive regulation of fatty acid transport (GO:2000193)2.61042173
170multicellular organism reproduction (GO:0032504)2.60634931
171regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.58897728
172establishment of protein localization to mitochondrial membrane (GO:0090151)2.57859291
173cytidine deamination (GO:0009972)2.54751148
174cytidine metabolic process (GO:0046087)2.54751148
175cytidine catabolic process (GO:0006216)2.54751148
176cornea development in camera-type eye (GO:0061303)2.54546496
177regulation of rhodopsin mediated signaling pathway (GO:0022400)2.54394208
178positive regulation of prostaglandin secretion (GO:0032308)2.53992639
179nonmotile primary cilium assembly (GO:0035058)2.53231468
180retinal cone cell development (GO:0046549)2.52976731
181negative regulation of protein oligomerization (GO:0032460)2.51152453
182rhodopsin mediated signaling pathway (GO:0016056)2.50707652
183cellular biogenic amine catabolic process (GO:0042402)2.50577443
184amine catabolic process (GO:0009310)2.50577443
185negative regulation of transcription regulatory region DNA binding (GO:2000678)2.48219991
186negative regulation of DNA-dependent DNA replication (GO:2000104)2.48015216
187resolution of meiotic recombination intermediates (GO:0000712)2.47606315
188mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.46273914
189GPI anchor metabolic process (GO:0006505)2.44600817
190amino acid salvage (GO:0043102)2.44583067
191L-methionine salvage (GO:0071267)2.44583067
192L-methionine biosynthetic process (GO:0071265)2.44583067
193ubiquinone metabolic process (GO:0006743)2.42997914

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.16313281
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.37260685
3ZNF274_21170338_ChIP-Seq_K562_Hela4.26750409
4MYC_18555785_ChIP-Seq_MESCs_Mouse4.11881352
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.95197490
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.67722316
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.53736792
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.43811178
9EST1_17652178_ChIP-ChIP_JURKAT_Human3.18428255
10VDR_22108803_ChIP-Seq_LS180_Human3.16115984
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.15684589
12GABP_17652178_ChIP-ChIP_JURKAT_Human3.12052800
13ETS1_20019798_ChIP-Seq_JURKAT_Human3.00594109
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.88834238
15MYC_18358816_ChIP-ChIP_MESCs_Mouse2.82476765
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.78672485
17MYC_19030024_ChIP-ChIP_MESCs_Mouse2.74709137
18MYC_19079543_ChIP-ChIP_MESCs_Mouse2.72700023
19MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.54039227
20VDR_23849224_ChIP-Seq_CD4+_Human2.47770096
21HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.40991023
22SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.39805860
23EZH2_22144423_ChIP-Seq_EOC_Human2.36579023
24IGF1R_20145208_ChIP-Seq_DFB_Human2.35047178
25GBX2_23144817_ChIP-Seq_PC3_Human2.34060746
26ELF1_17652178_ChIP-ChIP_JURKAT_Human2.31855608
27CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.30186921
28XRN2_22483619_ChIP-Seq_HELA_Human2.29596383
29ZFP57_27257070_Chip-Seq_ESCs_Mouse2.23283348
30E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.20590241
31AR_21909140_ChIP-Seq_LNCAP_Human2.19170571
32FOXP3_21729870_ChIP-Seq_TREG_Human2.17720703
33FLI1_27457419_Chip-Seq_LIVER_Mouse2.17573818
34GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.15784419
35EWS_26573619_Chip-Seq_HEK293_Human2.10566071
36NELFA_20434984_ChIP-Seq_ESCs_Mouse2.08929905
37HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.07029379
38CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.98933844
39E2F1_18555785_ChIP-Seq_MESCs_Mouse1.97008413
40DCP1A_22483619_ChIP-Seq_HELA_Human1.96856869
41POU3F2_20337985_ChIP-ChIP_501MEL_Human1.96555938
42EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.96505987
43FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.96295928
44CTBP1_25329375_ChIP-Seq_LNCAP_Human1.95705930
45E2F1_21310950_ChIP-Seq_MCF-7_Human1.95668625
46THAP11_20581084_ChIP-Seq_MESCs_Mouse1.95184908
47SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.93834901
48CTBP2_25329375_ChIP-Seq_LNCAP_Human1.93452624
49MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.91698013
50TTF2_22483619_ChIP-Seq_HELA_Human1.85869177
51GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.84814742
52GABP_19822575_ChIP-Seq_HepG2_Human1.83711569
53MYCN_18555785_ChIP-Seq_MESCs_Mouse1.82692657
54FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.82180524
55FUS_26573619_Chip-Seq_HEK293_Human1.79500981
56ER_23166858_ChIP-Seq_MCF-7_Human1.79241760
57P300_19829295_ChIP-Seq_ESCs_Human1.75286764
58TP53_22573176_ChIP-Seq_HFKS_Human1.75001989
59MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.74883356
60POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.69209772
61PCGF2_27294783_Chip-Seq_ESCs_Mouse1.68077308
62ELK1_19687146_ChIP-ChIP_HELA_Human1.64293786
63HOXB4_20404135_ChIP-ChIP_EML_Mouse1.63594431
64TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.63481343
65NANOG_18555785_ChIP-Seq_MESCs_Mouse1.62928968
66MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.62868358
67PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.61609031
68TAF15_26573619_Chip-Seq_HEK293_Human1.61207667
69SRF_21415370_ChIP-Seq_HL-1_Mouse1.54856552
70CIITA_25753668_ChIP-Seq_RAJI_Human1.53193192
71NOTCH1_21737748_ChIP-Seq_TLL_Human1.52831371
72SALL1_21062744_ChIP-ChIP_HESCs_Human1.52336215
73CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.51693323
74FOXA1_27270436_Chip-Seq_PROSTATE_Human1.49909219
75FOXA1_25329375_ChIP-Seq_VCAP_Human1.49909219
76YY1_21170310_ChIP-Seq_MESCs_Mouse1.48278553
77ERG_20887958_ChIP-Seq_HPC-7_Mouse1.46443151
78CBP_20019798_ChIP-Seq_JUKART_Human1.45634100
79IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.45634100
80SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.44598723
81YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.41958662
82FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.41932640
83BCAT_22108803_ChIP-Seq_LS180_Human1.41737566
84ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.38887610
85UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.38562389
86PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.37801376
87MYC_22102868_ChIP-Seq_BL_Human1.37570491
88ZFX_18555785_ChIP-Seq_MESCs_Mouse1.37396302
89GATA3_21878914_ChIP-Seq_MCF-7_Human1.36980091
90SOX2_19829295_ChIP-Seq_ESCs_Human1.36925689
91NANOG_19829295_ChIP-Seq_ESCs_Human1.36925689
92GATA1_22025678_ChIP-Seq_K562_Human1.36065932
93KDM5A_27292631_Chip-Seq_BREAST_Human1.34318699
94AR_20517297_ChIP-Seq_VCAP_Human1.30806241
95ETV2_25802403_ChIP-Seq_MESCs_Mouse1.30497756
96BMI1_23680149_ChIP-Seq_NPCS_Mouse1.29158524
97GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.28212323
98KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.27113202
99NCOR_22424771_ChIP-Seq_293T_Human1.26457997
100AR_25329375_ChIP-Seq_VCAP_Human1.23866581
101E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.23858015
102STAT3_23295773_ChIP-Seq_U87_Human1.23130057
103SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.23031745
104HOXB7_26014856_ChIP-Seq_BT474_Human1.22732150
105CBX2_27304074_Chip-Seq_ESCs_Mouse1.22579394
106CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.22514300
107EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.22381231
108MYC_18940864_ChIP-ChIP_HL60_Human1.21376270
109EGR1_23403033_ChIP-Seq_LIVER_Mouse1.21081647
110AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.20037196
111PCGF2_27294783_Chip-Seq_NPCs_Mouse1.19448933
112TCF4_23295773_ChIP-Seq_U87_Human1.18778417
113FOXA1_21572438_ChIP-Seq_LNCaP_Human1.17099736
114SPI1_23547873_ChIP-Seq_NB4_Human1.16415729
115TCF4_22108803_ChIP-Seq_LS180_Human1.14685986
116NFE2_27457419_Chip-Seq_LIVER_Mouse1.14031329
117POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.12611391
118KLF4_18555785_ChIP-Seq_MESCs_Mouse1.11944887
119SUZ12_27294783_Chip-Seq_NPCs_Mouse1.11342379
120ELK1_22589737_ChIP-Seq_MCF10A_Human1.10948543
121CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.10630657
122AUTS2_25519132_ChIP-Seq_293T-REX_Human1.10575654
123SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.09625922
124REST_21632747_ChIP-Seq_MESCs_Mouse1.09460306
125TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09365407
126SMAD4_21799915_ChIP-Seq_A2780_Human1.08627671
127MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.08390927
128EGR1_19374776_ChIP-ChIP_THP-1_Human1.08063877
129KLF5_20875108_ChIP-Seq_MESCs_Mouse1.08040851
130EZH2_27294783_Chip-Seq_NPCs_Mouse1.06926729
131NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.06276311
132TFEB_21752829_ChIP-Seq_HELA_Human1.05867778
133MYC_19829295_ChIP-Seq_ESCs_Human1.05334715
134VDR_21846776_ChIP-Seq_THP-1_Human1.05132428
135ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.04618599
136NANOG_20526341_ChIP-Seq_ESCs_Human1.04094326
137NR3C1_21868756_ChIP-Seq_MCF10A_Human1.04060923
138SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.03011169
139CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.03008556
140PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.02818940
141DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.01457439
142GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.01185706
143RNF2_27304074_Chip-Seq_NSC_Mouse1.00914016
144TAF2_19829295_ChIP-Seq_ESCs_Human1.00476712
145ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.00317951
146ERA_21632823_ChIP-Seq_H3396_Human0.99259711
147PADI4_21655091_ChIP-ChIP_MCF-7_Human0.98763998
148TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98697261
149POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.98697261
150KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.98135164
151PRDM14_20953172_ChIP-Seq_ESCs_Human0.97760505
152TOP2B_26459242_ChIP-Seq_MCF-7_Human0.97529502
153PIAS1_25552417_ChIP-Seq_VCAP_Human0.97366243
154SMAD4_21741376_ChIP-Seq_EPCs_Human0.96982051
155RUNX2_22187159_ChIP-Seq_PCA_Human0.96635176
156CRX_20693478_ChIP-Seq_RETINA_Mouse0.95758018
157CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.95018052
158STAT3_1855785_ChIP-Seq_MESCs_Mouse0.94279958
159FOXH1_21741376_ChIP-Seq_EPCs_Human0.94172815
160CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.92963908
161CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.92713207
162RBPJ_22232070_ChIP-Seq_NCS_Mouse0.89677002
163IRF1_19129219_ChIP-ChIP_H3396_Human0.89593981
164BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.89571974
165CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.85357279
166FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81431181
167CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.80116949
168SOX2_18555785_ChIP-Seq_MESCs_Mouse0.80086955
169HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.78390439
170IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.77417242
171RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.77416222
172MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.76830266
173STAT4_19710469_ChIP-ChIP_TH1__Mouse0.74652546
174KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.74619878
175NANOG_21062744_ChIP-ChIP_HESCs_Human0.74528130
176CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.74294897
177POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.70265671
178MAF_26560356_Chip-Seq_TH2_Human0.69313436
179MYB_21317192_ChIP-Seq_ERMYB_Mouse0.68351233

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.57563033
2MP0003111_abnormal_nucleus_morphology4.75556051
3MP0010094_abnormal_chromosome_stability4.57330563
4MP0004957_abnormal_blastocyst_morpholog4.37168218
5MP0003077_abnormal_cell_cycle4.14081962
6MP0008007_abnormal_cellular_replicative3.46514121
7MP0008058_abnormal_DNA_repair3.29264063
8MP0008057_abnormal_DNA_replication3.27436470
9MP0003950_abnormal_plasma_membrane3.07754405
10MP0002396_abnormal_hematopoietic_system3.06958471
11MP0003195_calcinosis2.88568804
12MP0009379_abnormal_foot_pigmentation2.74520854
13MP0002876_abnormal_thyroid_physiology2.46865397
14MP0002254_reproductive_system_inflammat2.46384458
15MP0005551_abnormal_eye_electrophysiolog2.44820345
16MP0008932_abnormal_embryonic_tissue2.42777013
17MP0002102_abnormal_ear_morphology2.38816977
18MP0004147_increased_porphyrin_level2.37340686
19MP0003718_maternal_effect2.34477520
20MP0003806_abnormal_nucleotide_metabolis2.31670273
21MP0002837_dystrophic_cardiac_calcinosis2.25997305
22MP0009333_abnormal_splenocyte_physiolog2.20775984
23MP0000372_irregular_coat_pigmentation2.13902004
24MP0000569_abnormal_digit_pigmentation2.03440794
25MP0003646_muscle_fatigue2.02004004
26MP0000350_abnormal_cell_proliferation2.01203057
27MP0001968_abnormal_touch/_nociception2.00229759
28MP0001730_embryonic_growth_arrest1.96227024
29MP0008875_abnormal_xenobiotic_pharmacok1.95074035
30MP0004885_abnormal_endolymph1.92926724
31MP0009046_muscle_twitch1.90245671
32MP0008872_abnormal_physiological_respon1.86194461
33MP0003786_premature_aging1.85162580
34MP0002736_abnormal_nociception_after1.83469113
35MP0002938_white_spotting1.78777469
36MP0000490_abnormal_crypts_of1.78287917
37MP0005253_abnormal_eye_physiology1.77396827
38MP0005174_abnormal_tail_pigmentation1.75715737
39MP0002163_abnormal_gland_morphology1.75658678
40MP0005645_abnormal_hypothalamus_physiol1.72002029
41MP0004142_abnormal_muscle_tone1.71337896
42MP0002638_abnormal_pupillary_reflex1.65762710
43MP0009745_abnormal_behavioral_response1.64234214
44MP0004043_abnormal_pH_regulation1.61018450
45MP0000015_abnormal_ear_pigmentation1.59902473
46MP0003787_abnormal_imprinting1.59253680
47MP0003011_delayed_dark_adaptation1.57686108
48MP0000313_abnormal_cell_death1.53515484
49MP0005075_abnormal_melanosome_morpholog1.53433956
50MP0000427_abnormal_hair_cycle1.52885494
51MP0008877_abnormal_DNA_methylation1.50495348
52MP0002138_abnormal_hepatobiliary_system1.48817328
53MP0006082_CNS_inflammation1.48642469
54MP0002398_abnormal_bone_marrow1.47113661
55MP0003656_abnormal_erythrocyte_physiolo1.46155684
56MP0006292_abnormal_olfactory_placode1.44713469
57MP0005084_abnormal_gallbladder_morpholo1.43428540
58MP0002272_abnormal_nervous_system1.43383740
59MP0005646_abnormal_pituitary_gland1.42283449
60MP0002019_abnormal_tumor_incidence1.40852107
61MP0003763_abnormal_thymus_physiology1.39786653
62MP0001529_abnormal_vocalization1.38564865
63MP0002080_prenatal_lethality1.33963650
64MP0001986_abnormal_taste_sensitivity1.33148182
65MP0006276_abnormal_autonomic_nervous1.31510542
66MP0000689_abnormal_spleen_morphology1.31415970
67MP0001501_abnormal_sleep_pattern1.31157394
68MP0004808_abnormal_hematopoietic_stem1.30779935
69MP0001485_abnormal_pinna_reflex1.29152736
70MP0000631_abnormal_neuroendocrine_gland1.28498893
71MP0001873_stomach_inflammation1.28488481
72MP0001697_abnormal_embryo_size1.28428010
73MP0002095_abnormal_skin_pigmentation1.27196481
74MP0002210_abnormal_sex_determination1.26669682
75MP0000703_abnormal_thymus_morphology1.23324952
76MP0003315_abnormal_perineum_morphology1.22993120
77MP0001984_abnormal_olfaction1.21734898
78MP0002722_abnormal_immune_system1.20416472
79MP0002429_abnormal_blood_cell1.17636613
80MP0000465_gastrointestinal_hemorrhage1.17164623
81MP0002277_abnormal_respiratory_mucosa1.16585153
82MP0001145_abnormal_male_reproductive1.15072847
83MP0004133_heterotaxia1.14775196
84MP0002735_abnormal_chemical_nociception1.14055783
85MP0005379_endocrine/exocrine_gland_phen1.13118205
86MP0001672_abnormal_embryogenesis/_devel1.13020433
87MP0005380_embryogenesis_phenotype1.13020433
88MP0002653_abnormal_ependyma_morphology1.12664565
89MP0005671_abnormal_response_to1.11917261
90MP0005410_abnormal_fertilization1.11234599
91MP0003186_abnormal_redox_activity1.10717842
92MP0000716_abnormal_immune_system1.10614531
93MP0001929_abnormal_gametogenesis1.10208398
94MP0001486_abnormal_startle_reflex1.09155226
95MP0004742_abnormal_vestibular_system1.07971805
96MP0010307_abnormal_tumor_latency1.06120679
97MP0002557_abnormal_social/conspecific_i1.04644310
98MP0000653_abnormal_sex_gland1.04151172
99MP0004145_abnormal_muscle_electrophysio1.03499566
100MP0005195_abnormal_posterior_eye1.01584808
101MP0005397_hematopoietic_system_phenotyp1.01356263
102MP0001545_abnormal_hematopoietic_system1.01356263
103MP0001970_abnormal_pain_threshold1.00520411
104MP0002085_abnormal_embryonic_tissue1.00281777
105MP0002132_abnormal_respiratory_system0.98242530
106MP0006036_abnormal_mitochondrial_physio0.97986429
107MP0002733_abnormal_thermal_nociception0.97807275
108MP0001348_abnormal_lacrimal_gland0.97731484
109MP0003698_abnormal_male_reproductive0.96461145
110MP0001764_abnormal_homeostasis0.96323702
111MP0001800_abnormal_humoral_immune0.96074723
112MP0002420_abnormal_adaptive_immunity0.95962459
113MP0001905_abnormal_dopamine_level0.95931397
114MP0003123_paternal_imprinting0.95704627
115MP0001188_hyperpigmentation0.95645677
116MP0002928_abnormal_bile_duct0.95485779
117MP0002064_seizures0.95453104
118MP0002572_abnormal_emotion/affect_behav0.95232081
119MP0003252_abnormal_bile_duct0.94269786
120MP0008789_abnormal_olfactory_epithelium0.94251334
121MP0003984_embryonic_growth_retardation0.93774276
122MP0001819_abnormal_immune_cell0.92824683
123MP0002088_abnormal_embryonic_growth/wei0.91798116
124MP0005386_behavior/neurological_phenoty0.91182008
125MP0004924_abnormal_behavior0.91182008
126MP0002234_abnormal_pharynx_morphology0.89592382
127MP0002452_abnormal_antigen_presenting0.89155407
128MP0002067_abnormal_sensory_capabilities0.88432167
129MP0005332_abnormal_amino_acid0.86632780
130MP0005310_abnormal_salivary_gland0.86503160
131MP0002693_abnormal_pancreas_physiology0.85107609
132MP0002723_abnormal_immune_serum0.85075362
133MP0000858_altered_metastatic_potential0.84729164
134MP0003283_abnormal_digestive_organ0.83575887
135MP0003880_abnormal_central_pattern0.82296978
136MP0003567_abnormal_fetal_cardiomyocyte0.81757089
137MP0001853_heart_inflammation0.81379418
138MP0010386_abnormal_urinary_bladder0.81020552
139MP0002229_neurodegeneration0.80663061
140MP0001919_abnormal_reproductive_system0.80632841
141MP0003878_abnormal_ear_physiology0.80163625
142MP0005377_hearing/vestibular/ear_phenot0.80163625
143MP0001119_abnormal_female_reproductive0.80033379
144MP0002752_abnormal_somatic_nervous0.78150500
145MP0005000_abnormal_immune_tolerance0.77189985
146MP0006035_abnormal_mitochondrial_morpho0.77076346
147MP0002751_abnormal_autonomic_nervous0.75893095
148MP0005025_abnormal_response_to0.75664178
149MP0003436_decreased_susceptibility_to0.75659087
150MP0005167_abnormal_blood-brain_barrier0.75605704
151MP0005085_abnormal_gallbladder_physiolo0.75453911
152MP0006072_abnormal_retinal_apoptosis0.75104061
153MP0002405_respiratory_system_inflammati0.72819132
154MP0003136_yellow_coat_color0.71077844
155MP0002086_abnormal_extraembryonic_tissu0.70851085
156MP0001293_anophthalmia0.69112188
157MP0002084_abnormal_developmental_patter0.68945136
158MP0005389_reproductive_system_phenotype0.66956791
159MP0000685_abnormal_immune_system0.66729504
160MP0004381_abnormal_hair_follicle0.62303976
161MP0003943_abnormal_hepatobiliary_system0.62254830
162MP0001542_abnormal_bone_strength0.61165865
163MP0002160_abnormal_reproductive_system0.60488748
164MP0000566_synostosis0.60304363
165MP0000358_abnormal_cell_content/0.59685603
166MP0005384_cellular_phenotype0.59623963
167MP0001835_abnormal_antigen_presentation0.58793759
168MP0004197_abnormal_fetal_growth/weight/0.58557884
169MP0002419_abnormal_innate_immunity0.57723442
170MP0003303_peritoneal_inflammation0.57182197
171MP0002148_abnormal_hypersensitivity_rea0.56240043
172MP0002092_abnormal_eye_morphology0.56212168
173MP0005621_abnormal_cell_physiology0.55233464
174MP0009785_altered_susceptibility_to0.55030699
175MP0005220_abnormal_exocrine_pancreas0.54064524
176MP0003221_abnormal_cardiomyocyte_apopto0.53902165

Predicted human phenotypes

RankGene SetZ-score
1Aplastic anemia (HP:0001915)5.61020461
2Birth length less than 3rd percentile (HP:0003561)5.20873093
3Abnormality of the heme biosynthetic pathway (HP:0010472)4.37072875
4Cerebral hypomyelination (HP:0006808)4.33816361
5Reticulocytopenia (HP:0001896)4.31082423
6Abnormality of cells of the erythroid lineage (HP:0012130)4.26949338
7Abnormal number of erythroid precursors (HP:0012131)4.24622967
8Pancreatic cysts (HP:0001737)4.02349927
9Breast hypoplasia (HP:0003187)4.00386460
10Congenital stationary night blindness (HP:0007642)3.99251362
11Type II lissencephaly (HP:0007260)3.80622485
12Abnormality of midbrain morphology (HP:0002418)3.73979910
13Molar tooth sign on MRI (HP:0002419)3.73979910
14Rough bone trabeculation (HP:0100670)3.68204113
15Chromsome breakage (HP:0040012)3.61108449
16Pancreatic fibrosis (HP:0100732)3.56931731
17Macrocytic anemia (HP:0001972)3.46524313
18Abnormality of the anterior horn cell (HP:0006802)3.45592065
19Degeneration of anterior horn cells (HP:0002398)3.45592065
20True hermaphroditism (HP:0010459)3.39642697
21Pallor (HP:0000980)3.32219098
22Chromosomal breakage induced by crosslinking agents (HP:0003221)3.29574437
23Nephronophthisis (HP:0000090)3.21716649
24Oral leukoplakia (HP:0002745)3.18783180
25Carpal bone hypoplasia (HP:0001498)3.10781084
26Secondary amenorrhea (HP:0000869)3.07162575
27Bone marrow hypocellularity (HP:0005528)3.05906816
28Chronic sinusitis (HP:0011109)3.03740916
29Attenuation of retinal blood vessels (HP:0007843)3.01187112
30Patellar aplasia (HP:0006443)2.99416482
31Abnormal rod and cone electroretinograms (HP:0008323)2.94690541
32Microretrognathia (HP:0000308)2.86317812
33Aplasia/Hypoplasia of the patella (HP:0006498)2.83293567
34Abolished electroretinogram (ERG) (HP:0000550)2.82084647
35Pancytopenia (HP:0001876)2.78808848
36Abnormality of the preputium (HP:0100587)2.78478381
37Pulmonary fibrosis (HP:0002206)2.77509160
38Cerebellar dysplasia (HP:0007033)2.76074840
39Abnormality of the renal cortex (HP:0011035)2.74246952
40Abnormality of the renal medulla (HP:0100957)2.72841946
41Medial flaring of the eyebrow (HP:0010747)2.72447903
42Mitochondrial inheritance (HP:0001427)2.67932997
43Abnormality of chromosome stability (HP:0003220)2.67113705
44Premature graying of hair (HP:0002216)2.66558741
45Increased CSF lactate (HP:0002490)2.65755692
46Myelodysplasia (HP:0002863)2.65415282
47Meckel diverticulum (HP:0002245)2.64620336
48Abnormality of the pons (HP:0007361)2.64363479
49Abnormal trabecular bone morphology (HP:0100671)2.63437554
50Acute necrotizing encephalopathy (HP:0006965)2.59737556
51Hypoplasia of the pons (HP:0012110)2.59234544
52Absent rod-and cone-mediated responses on ERG (HP:0007688)2.58009597
53Aplasia/Hypoplasia of the sacrum (HP:0008517)2.57424958
54Hypoplasia of the capital femoral epiphysis (HP:0003090)2.55490543
55Decreased electroretinogram (ERG) amplitude (HP:0000654)2.50966529
56Recurrent bronchitis (HP:0002837)2.50607533
57Hepatocellular necrosis (HP:0001404)2.50181906
58Abnormality of the ileum (HP:0001549)2.48551862
59Pendular nystagmus (HP:0012043)2.47561543
60Hyperventilation (HP:0002883)2.43598921
61Methylmalonic acidemia (HP:0002912)2.43332045
62Lissencephaly (HP:0001339)2.40923632
63Chronic hepatic failure (HP:0100626)2.37546126
64Polydipsia (HP:0001959)2.36960401
65Abnormal drinking behavior (HP:0030082)2.36960401
66Aplasia/Hypoplasia of the uvula (HP:0010293)2.36218859
67Aplasia/Hypoplasia of the tibia (HP:0005772)2.34640883
68Aplasia/Hypoplasia of the spleen (HP:0010451)2.34588258
69Acute encephalopathy (HP:0006846)2.32046622
70Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.30204368
71CNS hypomyelination (HP:0003429)2.30167506
72Hepatic necrosis (HP:0002605)2.29918934
73Decreased central vision (HP:0007663)2.27143730
74Progressive macrocephaly (HP:0004481)2.26760222
75Sloping forehead (HP:0000340)2.25810091
76Abnormal mitochondria in muscle tissue (HP:0008316)2.25473478
77Type I transferrin isoform profile (HP:0003642)2.25192110
78Chronic otitis media (HP:0000389)2.24490702
79IgM deficiency (HP:0002850)2.23916145
80Abnormality of alanine metabolism (HP:0010916)2.22913071
81Hyperalaninemia (HP:0003348)2.22913071
82Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.22913071
83Abnormality of the labia minora (HP:0012880)2.22549345
84Stomach cancer (HP:0012126)2.22112853
85Cystic liver disease (HP:0006706)2.21994574
86Retinal dysplasia (HP:0007973)2.21703476
87Asplenia (HP:0001746)2.21518793
88Sclerocornea (HP:0000647)2.20667360
89Petechiae (HP:0000967)2.20419267
90Small intestinal stenosis (HP:0012848)2.19019086
91Duodenal stenosis (HP:0100867)2.19019086
92Duplicated collecting system (HP:0000081)2.18190500
93Slender long bone (HP:0003100)2.17949074
94Congenital, generalized hypertrichosis (HP:0004540)2.17843814
95Methylmalonic aciduria (HP:0012120)2.16771802
96Absent thumb (HP:0009777)2.15887388
97Inability to walk (HP:0002540)2.15751888
98Microvesicular hepatic steatosis (HP:0001414)2.15297493
99Abnormality of the renal collecting system (HP:0004742)2.15263255
100Hypothermia (HP:0002045)2.14032399
101Tubular atrophy (HP:0000092)2.13299893
102Squamous cell carcinoma (HP:0002860)2.11740867
103Absent radius (HP:0003974)2.11118353
104Premature ovarian failure (HP:0008209)2.10313282
105Horseshoe kidney (HP:0000085)2.10013686
106Megaloblastic anemia (HP:0001889)2.09997811
107Bony spicule pigmentary retinopathy (HP:0007737)2.09646905
108Impulsivity (HP:0100710)2.09445043
109Supernumerary spleens (HP:0009799)2.09367419
110Progressive inability to walk (HP:0002505)2.08374851
111Gait imbalance (HP:0002141)2.07434027
112Triphalangeal thumb (HP:0001199)2.07399707
113Acute myeloid leukemia (HP:0004808)2.06273862
114Cutaneous photosensitivity (HP:0000992)2.05447548
115Lipid accumulation in hepatocytes (HP:0006561)2.05433940
116Duplication of thumb phalanx (HP:0009942)2.05150494
117Optic disc pallor (HP:0000543)2.04911412
118Severe muscular hypotonia (HP:0006829)2.04141974
119Lymphoma (HP:0002665)2.03547965
120Neoplasm of the pancreas (HP:0002894)2.03362021
121Congenital primary aphakia (HP:0007707)2.03265269
122Increased corneal curvature (HP:0100692)2.02355928
123Keratoconus (HP:0000563)2.02355928
124Renal cortical cysts (HP:0000803)2.01942059
125Entropion (HP:0000621)2.01836431
126Acute lymphatic leukemia (HP:0006721)2.01619209
127Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.00291150
128Brushfield spots (HP:0001088)1.99520154
129Furrowed tongue (HP:0000221)1.99373959
130Short tibia (HP:0005736)1.99359196
131Polyuria (HP:0000103)1.98914897
132Aplasia involving forearm bones (HP:0009822)1.98775466
133Absent forearm bone (HP:0003953)1.98775466
134Cellular immunodeficiency (HP:0005374)1.98121700
1353-Methylglutaconic aciduria (HP:0003535)1.98079331
136Trismus (HP:0000211)1.97121576
137Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.96799038
138Cleft eyelid (HP:0000625)1.96077898
139Cellulitis (HP:0100658)1.95655076
140Reduced antithrombin III activity (HP:0001976)1.94925363
141Stomatitis (HP:0010280)1.93331403
142Absent/shortened dynein arms (HP:0200106)1.93093466
143Dynein arm defect of respiratory motile cilia (HP:0012255)1.93093466
144Large for gestational age (HP:0001520)1.92826096
145Aplasia/Hypoplasia of the fovea (HP:0008060)1.91801611
146Hypoplasia of the fovea (HP:0007750)1.91801611
147Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.91281522
148Absent epiphyses (HP:0010577)1.91281522
149Selective tooth agenesis (HP:0001592)1.90286498
150Sparse eyelashes (HP:0000653)1.89758612
15111 pairs of ribs (HP:0000878)1.89552090
152Nephrogenic diabetes insipidus (HP:0009806)1.88432496
153Hypopigmented skin patches (HP:0001053)1.88344637
154IgG deficiency (HP:0004315)1.87072143
155Thrombocytosis (HP:0001894)1.86572395
156Gaze-evoked nystagmus (HP:0000640)1.85378656
157Male pseudohermaphroditism (HP:0000037)1.85320584
158Anencephaly (HP:0002323)1.85052059
159Clubbing of toes (HP:0100760)1.84951952
160Tracheoesophageal fistula (HP:0002575)1.84794863
161Abnormal lung lobation (HP:0002101)1.84662955
162Short thumb (HP:0009778)1.84558679
163Clumsiness (HP:0002312)1.83123894
164Aplasia/Hypoplasia of the tongue (HP:0010295)1.80933350
165Congenital hepatic fibrosis (HP:0002612)1.80336766
166Progressive muscle weakness (HP:0003323)1.80302593
167Pachygyria (HP:0001302)1.79071994
168Small epiphyses (HP:0010585)1.78669351
169Abnormality of the proximal phalanges of the hand (HP:0009834)1.78521579
170Increased hepatocellular lipid droplets (HP:0006565)1.78301009
171Constricted visual fields (HP:0001133)1.77866235
172Abnormality of the duodenum (HP:0002246)1.77312212
173Concave nail (HP:0001598)1.76816219
174Increased serum lactate (HP:0002151)1.76735204
175Abnormal spermatogenesis (HP:0008669)1.76593323
176Postaxial foot polydactyly (HP:0001830)1.76017806
177Aplasia/hypoplasia of the uterus (HP:0008684)1.76001596
178Colon cancer (HP:0003003)1.74937294
179Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.74845337
180Abnormal protein N-linked glycosylation (HP:0012347)1.74845337
181Abnormal protein glycosylation (HP:0012346)1.74845337
182Abnormal glycosylation (HP:0012345)1.74845337
183Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.74791115
184Decreased circulating renin level (HP:0003351)1.74699363
185Ureteral duplication (HP:0000073)1.74525725
186Abnormality of macular pigmentation (HP:0008002)1.74141157
187Atrophy/Degeneration involving motor neurons (HP:0007373)1.73933333
188Optic nerve hypoplasia (HP:0000609)1.72251815

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB16.16017354
2FRK5.03397775
3WEE13.75734818
4CDC73.44555526
5EIF2AK13.33977728
6ADRBK23.03393069
7SRPK12.90951338
8EIF2AK32.89737679
9STK162.85635940
10TESK22.81979871
11NUAK12.77438620
12NEK22.54049963
13MKNK22.52962359
14WNK32.51283070
15MAP4K22.48145579
16TAOK32.40954563
17IRAK42.40626979
18VRK12.38716320
19BRSK22.37150652
20GRK12.27156269
21TLK12.26523712
22TTK2.24421336
23MKNK12.14511059
24DYRK32.08858549
25WNK42.08341684
26NME22.04234569
27PLK41.92239747
28RPS6KA41.74989787
29PLK11.71017647
30PINK11.65578897
31OXSR11.64347947
32MAPK131.63103459
33ACVR1B1.55860206
34AURKB1.54510902
35MAP3K131.51440685
36BRSK11.48301228
37CHEK21.45146410
38INSRR1.42177248
39VRK21.41520466
40PLK31.37201861
41AURKA1.35344678
42MAP4K11.34641006
43STK391.33928920
44CASK1.31227580
45TSSK61.30437208
46STK101.29884193
47CDK71.29808753
48BCKDK1.27650445
49BRAF1.26872022
50CCNB11.25098597
51TRIM281.20813170
52ATR1.19339997
53MAP3K41.19201828
54MAP3K81.16857456
55DAPK21.13672318
56CAMKK21.11137240
57PIM21.07220380
58STK41.06665926
59TNIK1.05963869
60NEK11.03243598
61ADRBK11.01610390
62TAF10.99689195
63EIF2AK20.98335307
64CLK10.96793630
65PAK30.93351839
66CHEK10.92430321
67TEC0.89730649
68CSNK1G20.88315013
69IKBKB0.88203586
70KIT0.87371637
71CDK80.84116577
72PIM10.83538811
73STK38L0.79390973
74PASK0.76814826
75CSNK1A1L0.75481269
76MAP2K70.75112523
77CDK40.75060988
78MAP3K110.73882284
79PBK0.72824151
80GRK60.72691223
81ATM0.71971808
82LRRK20.71823927
83PHKG10.71155627
84PHKG20.71155627
85PKN10.70232022
86PRKCG0.69558485
87PAK10.68344702
88MAPKAPK30.65663521
89PRKCE0.65372661
90RPS6KA50.65175766
91TIE10.64451620
92PRKCQ0.64418483
93DYRK20.63959058
94MAPKAPK50.63065898
95KDR0.62266776
96IRAK30.61932403
97CSNK2A10.61838777
98PLK20.61837243
99LIMK10.61358565
100MST40.61319607
101CDK20.58532701
102CAMKK10.57943908
103NME10.56208147
104ZAK0.54798727
105MAP2K60.54665433
106MAP3K100.54195397
107SCYL20.54191611
108CSNK2A20.53000939
109PTK2B0.52904024
110PAK40.50118115
111MARK10.49221738
112ERBB30.47309248
113BTK0.47288824
114CDK10.46940256
115GRK70.46267328
116MUSK0.46006309
117CSK0.45534051
118TXK0.45316981
119CDK190.44554018
120NTRK30.44507824
121TESK10.42906271
122MELK0.42734167
123SYK0.42713766
124CHUK0.41555007
125PNCK0.41365837
126MATK0.40863345
127RPS6KB20.40008615
128CSNK1A10.39583200
129MARK30.38495395
130MAP3K60.36907308
131CAMK2A0.36749012
132GRK50.35932624
133BLK0.35716793
134NLK0.35501698
135PRKACA0.35110227
136PIK3CA0.34084735
137MAP3K120.34058255
138FES0.34020532
139CSNK1G10.33637699
140STK110.32955566
141MAP3K140.32932637
142LYN0.32688084
143CSNK1G30.31914660
144IRAK10.31699154
145MAP3K70.31592745
146FGFR20.31368777
147PRKAA20.31186925
148MAP2K20.30546445
149MAPKAPK20.29289465
150JAK30.29267289
151ALK0.27167109
152PRKCI0.23499507
153TGFBR10.23270580
154LCK0.23086280
155CSNK1E0.22503550
156UHMK10.22137231
157BMPR1B0.20335129
158MAPK40.20092488
159ABL20.18620850
160RAF10.16750931
161BCR0.15297276
162ITK0.15079960

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.92078135
2Ribosome_Homo sapiens_hsa030103.85274690
3Mismatch repair_Homo sapiens_hsa034303.82748801
4RNA polymerase_Homo sapiens_hsa030203.60450105
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.51659626
6Proteasome_Homo sapiens_hsa030503.18202202
7Homologous recombination_Homo sapiens_hsa034403.17853529
8Base excision repair_Homo sapiens_hsa034102.99738114
9Spliceosome_Homo sapiens_hsa030402.98113798
10RNA transport_Homo sapiens_hsa030132.78325715
11Nucleotide excision repair_Homo sapiens_hsa034202.76773046
12Pyrimidine metabolism_Homo sapiens_hsa002402.73525236
13Cell cycle_Homo sapiens_hsa041102.70437480
14One carbon pool by folate_Homo sapiens_hsa006702.56218604
15Phototransduction_Homo sapiens_hsa047442.40534629
16Fanconi anemia pathway_Homo sapiens_hsa034602.23966333
17Basal transcription factors_Homo sapiens_hsa030222.18217014
18Non-homologous end-joining_Homo sapiens_hsa034502.12882986
19Butanoate metabolism_Homo sapiens_hsa006502.04464345
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.02635111
21Nitrogen metabolism_Homo sapiens_hsa009101.88483894
22Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.84209304
23RNA degradation_Homo sapiens_hsa030181.82637838
24Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.81019079
25Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.75888221
26Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.71666338
27Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.66176691
28Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.62991791
29Protein export_Homo sapiens_hsa030601.59922173
30Maturity onset diabetes of the young_Homo sapiens_hsa049501.59598493
31Vitamin B6 metabolism_Homo sapiens_hsa007501.57889916
32Caffeine metabolism_Homo sapiens_hsa002321.53713008
33Purine metabolism_Homo sapiens_hsa002301.53707037
34p53 signaling pathway_Homo sapiens_hsa041151.53372674
35Tryptophan metabolism_Homo sapiens_hsa003801.51837288
36Nicotine addiction_Homo sapiens_hsa050331.50566514
37Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.44635517
38Folate biosynthesis_Homo sapiens_hsa007901.39746461
39mRNA surveillance pathway_Homo sapiens_hsa030151.36248206
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.34336063
41Peroxisome_Homo sapiens_hsa041461.33723596
42Propanoate metabolism_Homo sapiens_hsa006401.33084659
43Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.31962647
44Sulfur metabolism_Homo sapiens_hsa009201.20132180
45Olfactory transduction_Homo sapiens_hsa047401.18914287
46Cardiac muscle contraction_Homo sapiens_hsa042601.17065771
47Epstein-Barr virus infection_Homo sapiens_hsa051691.11010889
48Collecting duct acid secretion_Homo sapiens_hsa049661.04286000
49Pentose phosphate pathway_Homo sapiens_hsa000301.02320417
50Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.00860838
51Chemical carcinogenesis_Homo sapiens_hsa052040.99851213
52Oocyte meiosis_Homo sapiens_hsa041140.99213703
53Primary immunodeficiency_Homo sapiens_hsa053400.96779228
54Steroid hormone biosynthesis_Homo sapiens_hsa001400.95217531
55Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.94429531
56Taste transduction_Homo sapiens_hsa047420.93383121
57ABC transporters_Homo sapiens_hsa020100.91458616
58Sulfur relay system_Homo sapiens_hsa041220.90508201
59Morphine addiction_Homo sapiens_hsa050320.88314787
60Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.87587774
61Primary bile acid biosynthesis_Homo sapiens_hsa001200.83712050
62Retinol metabolism_Homo sapiens_hsa008300.83353164
63Graft-versus-host disease_Homo sapiens_hsa053320.82894310
64Cysteine and methionine metabolism_Homo sapiens_hsa002700.80949841
65Antigen processing and presentation_Homo sapiens_hsa046120.80707989
66Systemic lupus erythematosus_Homo sapiens_hsa053220.78039437
67Type I diabetes mellitus_Homo sapiens_hsa049400.76533633
68Herpes simplex infection_Homo sapiens_hsa051680.76359463
69Thyroid cancer_Homo sapiens_hsa052160.75508190
70Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.75465619
71Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.72671910
72Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.72306018
73Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.71682335
74Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.71156042
75Glutathione metabolism_Homo sapiens_hsa004800.70780178
76Huntingtons disease_Homo sapiens_hsa050160.69188714
77Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.68337340
78Viral carcinogenesis_Homo sapiens_hsa052030.67683790
79Drug metabolism - other enzymes_Homo sapiens_hsa009830.67624954
80Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.65573608
81Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.64062794
82Parkinsons disease_Homo sapiens_hsa050120.63666673
83beta-Alanine metabolism_Homo sapiens_hsa004100.61895093
84Hematopoietic cell lineage_Homo sapiens_hsa046400.60214308
85Mineral absorption_Homo sapiens_hsa049780.58850215
86Glycerolipid metabolism_Homo sapiens_hsa005610.58366535
87HTLV-I infection_Homo sapiens_hsa051660.57931157
88Cyanoamino acid metabolism_Homo sapiens_hsa004600.56399376
89Selenocompound metabolism_Homo sapiens_hsa004500.55908598
90Sphingolipid metabolism_Homo sapiens_hsa006000.55360827
91Oxidative phosphorylation_Homo sapiens_hsa001900.54843007
92Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.54609450
93Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.53897627
94Ovarian steroidogenesis_Homo sapiens_hsa049130.53102948
95Serotonergic synapse_Homo sapiens_hsa047260.52830616
96Insulin secretion_Homo sapiens_hsa049110.51802571
97Intestinal immune network for IgA production_Homo sapiens_hsa046720.51619661
98Pentose and glucuronate interconversions_Homo sapiens_hsa000400.51297271
99Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.50788738
100Transcriptional misregulation in cancer_Homo sapiens_hsa052020.50700944
101Fat digestion and absorption_Homo sapiens_hsa049750.50589950
102Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.50376711
103Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.49463088
104Arachidonic acid metabolism_Homo sapiens_hsa005900.47348419
105GABAergic synapse_Homo sapiens_hsa047270.46383684
106SNARE interactions in vesicular transport_Homo sapiens_hsa041300.45904799
107Arginine and proline metabolism_Homo sapiens_hsa003300.43273508
108Fatty acid elongation_Homo sapiens_hsa000620.43235370
109Fatty acid degradation_Homo sapiens_hsa000710.42783471
110Biosynthesis of amino acids_Homo sapiens_hsa012300.42187885
111Rheumatoid arthritis_Homo sapiens_hsa053230.41812155
112NF-kappa B signaling pathway_Homo sapiens_hsa040640.40638107
113Apoptosis_Homo sapiens_hsa042100.39973397
114N-Glycan biosynthesis_Homo sapiens_hsa005100.39909051
115Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.39408635
116Metabolic pathways_Homo sapiens_hsa011000.36421576
117Measles_Homo sapiens_hsa051620.36092061
118Shigellosis_Homo sapiens_hsa051310.35067521
119Linoleic acid metabolism_Homo sapiens_hsa005910.34726084
120Fatty acid metabolism_Homo sapiens_hsa012120.32441177
121Legionellosis_Homo sapiens_hsa051340.30693677
122Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.30066656
123MicroRNAs in cancer_Homo sapiens_hsa052060.29287752
124Hepatitis B_Homo sapiens_hsa051610.27883605
125NOD-like receptor signaling pathway_Homo sapiens_hsa046210.25732667
126Ether lipid metabolism_Homo sapiens_hsa005650.25471983
127Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.25438043
128Alcoholism_Homo sapiens_hsa050340.25246322
129Regulation of autophagy_Homo sapiens_hsa041400.24814819
130Small cell lung cancer_Homo sapiens_hsa052220.23567406
131Other glycan degradation_Homo sapiens_hsa005110.22899407
132Leishmaniasis_Homo sapiens_hsa051400.22539846
133Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.22355004
134Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.21573066
135Asthma_Homo sapiens_hsa053100.20392673
136Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.17295053
137B cell receptor signaling pathway_Homo sapiens_hsa046620.16772110
138Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.16256175
139Bladder cancer_Homo sapiens_hsa052190.16120889
140Histidine metabolism_Homo sapiens_hsa003400.15151416
141alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.15126840
142Circadian rhythm_Homo sapiens_hsa047100.13695459
143Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.13354989
144Allograft rejection_Homo sapiens_hsa053300.12874956
145Vitamin digestion and absorption_Homo sapiens_hsa049770.12583008
146Influenza A_Homo sapiens_hsa051640.11391851
147T cell receptor signaling pathway_Homo sapiens_hsa046600.10294933
148Acute myeloid leukemia_Homo sapiens_hsa052210.09412541
149Notch signaling pathway_Homo sapiens_hsa043300.08675861
150RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.08379455
151Autoimmune thyroid disease_Homo sapiens_hsa053200.08344058
152Alzheimers disease_Homo sapiens_hsa050100.08058187
153Pertussis_Homo sapiens_hsa051330.07459464

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »