ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	detection of visible light (GO:0009584)	9.72349913
2	detection of light stimulus (GO:0009583)	9.68194389
3	regulation of guanylate cyclase activity (GO:0031282)	9.41930648
4	GMP metabolic process (GO:0046037)	9.30410752
5	protein-chromophore linkage (GO:0018298)	9.17589314
6	retinal rod cell development (GO:0046548)	8.44367674
7	visual perception (GO:0007601)	8.33829921
8	sensory perception of light stimulus (GO:0050953)	8.24156727
9	cellular response to light stimulus (GO:0071482)	7.13062379
10	eye photoreceptor cell differentiation (GO:0001754)	6.86054958
11	photoreceptor cell differentiation (GO:0046530)	6.86054958
12	detection of external stimulus (GO:0009581)	6.77616180
13	regulation of cGMP metabolic process (GO:0030823)	6.66321993
14	detection of abiotic stimulus (GO:0009582)	6.64127470
15	retina development in camera-type eye (GO:0060041)	6.30350520
16	positive regulation of cGMP biosynthetic process (GO:0030828)	6.29314606
17	regulation of cGMP biosynthetic process (GO:0030826)	5.93245971
18	detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)	5.70990265
19	positive regulation of cGMP metabolic process (GO:0030825)	5.52063592
20	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	5.23286525
21	receptor guanylyl cyclase signaling pathway (GO:0007168)	4.87734557
22	nonmotile primary cilium assembly (GO:0035058)	4.81945621
23	cellular response to radiation (GO:0071478)	4.57529363
24	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	4.45697454
25	cell morphogenesis involved in neuron differentiation (GO:0048667)	4.31533811
26	regulation of G-protein coupled receptor protein signaling pathway (GO:0008277)	4.16894524
27	adaptation of signaling pathway (GO:0023058)	4.13525190
28	sensory perception (GO:0007600)	3.89113656
29	regulation of voltage-gated calcium channel activity (GO:1901385)	3.83100810
30	sperm motility (GO:0030317)	3.80020926
31	detection of chemical stimulus involved in sensory perception of taste (GO:0050912)	3.76179348
32	response to light stimulus (GO:0009416)	3.71606885
33	short-term memory (GO:0007614)	3.69859669
34	motile cilium assembly (GO:0044458)	3.64539900
35	protein prenylation (GO:0018342)	3.64495464
36	prenylation (GO:0097354)	3.64495464
37	cell wall macromolecule metabolic process (GO:0044036)	3.51417195
38	cell wall macromolecule catabolic process (GO:0016998)	3.51417195
39	detection of chemical stimulus involved in sensory perception (GO:0050907)	3.50163688
40	regulation of penile erection (GO:0060405)	3.41325133
41	retina layer formation (GO:0010842)	3.39908044
42	positive regulation of sodium ion transmembrane transporter activity (GO:2000651)	3.37424779
43	neuron development (GO:0048666)	3.37202895
44	CDP-diacylglycerol biosynthetic process (GO:0016024)	3.34657794
45	regulation of dopamine uptake involved in synaptic transmission (GO:0051584)	3.33736012
46	regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)	3.33736012
47	behavioral response to ethanol (GO:0048149)	3.33063214
48	estrogen biosynthetic process (GO:0006703)	3.32197098
49	protein localization to synapse (GO:0035418)	3.24439971
50	response to histamine (GO:0034776)	3.20643590
51	axoneme assembly (GO:0035082)	3.18941905
52	chemosensory behavior (GO:0007635)	3.16443758
53	retina homeostasis (GO:0001895)	3.15261616
54	regulation of cilium movement (GO:0003352)	3.11774331
55	CDP-diacylglycerol metabolic process (GO:0046341)	3.07775874
56	positive regulation of sodium ion transmembrane transport (GO:1902307)	3.05326355
57	regulation of clathrin-mediated endocytosis (GO:2000369)	3.05148662
58	positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)	3.03498081
59	acrosome reaction (GO:0007340)	3.02634863
60	fusion of sperm to egg plasma membrane (GO:0007342)	3.00943834
61	phospholipid translocation (GO:0045332)	2.94188224
62	lipid translocation (GO:0034204)	2.94188224
63	negative regulation of receptor-mediated endocytosis (GO:0048261)	2.91046989
64	acrosome assembly (GO:0001675)	2.90644488
65	membrane hyperpolarization (GO:0060081)	2.90268049
66	positive regulation of excitatory postsynaptic membrane potential (GO:2000463)	2.85339053
67	positive regulation of epidermal growth factor receptor signaling pathway (GO:0045742)	2.85000482
68	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.84323908
69	retinoid metabolic process (GO:0001523)	2.81766457
70	positive regulation of neurotransmitter transport (GO:0051590)	2.79107209
71	arachidonic acid secretion (GO:0050482)	2.78988601
72	icosanoid secretion (GO:0032309)	2.78988601
73	sperm-egg recognition (GO:0035036)	2.77646521
74	multicellular organism reproduction (GO:0032504)	2.75139645
75	epithelial cilium movement (GO:0003351)	2.66809016
76	positive regulation of ERBB signaling pathway (GO:1901186)	2.64761234
77	retinol metabolic process (GO:0042572)	2.61439339
78	diterpenoid metabolic process (GO:0016101)	2.61172467
79	response to radiation (GO:0009314)	2.57765998
80	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	2.55813875
81	lactate metabolic process (GO:0006089)	2.55769185
82	positive regulation of cyclase activity (GO:0031281)	2.51684101
83	peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)	2.50834822
84	spermatid development (GO:0007286)	2.50371966
85	plasma membrane fusion (GO:0045026)	2.48570942
86	positive regulation of lyase activity (GO:0051349)	2.47201454
87	behavioral response to cocaine (GO:0048148)	2.46340707
88	cell-cell recognition (GO:0009988)	2.46149959
89	binding of sperm to zona pellucida (GO:0007339)	2.45026180
90	regulation of rhodopsin mediated signaling pathway (GO:0022400)	17.6004517
91	rhodopsin mediated signaling pathway (GO:0016056)	17.0639841
92	retinal cone cell development (GO:0046549)	15.7021359
93	photoreceptor cell development (GO:0042461)	11.8667682
94	eye photoreceptor cell development (GO:0042462)	11.4999547
95	detection of light stimulus involved in visual perception (GO:0050908)	11.1586212
96	detection of light stimulus involved in sensory perception (GO:0050962)	11.1586212
97	photoreceptor cell maintenance (GO:0045494)	11.1458233
98	positive regulation of guanylate cyclase activity (GO:0031284)	10.3811579
99	phototransduction (GO:0007602)	10.1288366
100	phototransduction, visible light (GO:0007603)	10.0471791

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	VDR_22108803_ChIP-Seq_LS180_Human	4.12188062
2	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	3.48346838
3	CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse	3.47357475
4	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	3.09531445
5	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	3.04882117
6	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.67595632
7	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	2.04573104
8	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.96122534
9	GBX2_23144817_ChIP-Seq_PC3_Human	1.85570400
10	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.78974115
11	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.78156472
12	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.64330192
13	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.62846071
14	DROSHA_22980978_ChIP-Seq_HELA_Human	1.61631901
15	REST_21632747_ChIP-Seq_MESCs_Mouse	1.61393452
16	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.56430616
17	NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse	1.55746653
18	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.51630423
19	ELK4_26923725_Chip-Seq_MESODERM_Mouse	1.49287667
20	STAT1_17558387_ChIP-Seq_HELA_Human	1.44259215
21	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.43591689
22	MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.43141936
23	SMAD3_21741376_ChIP-Seq_HESCs_Human	1.41965346
24	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.41683439
25	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.36875856
26	TBL1_22424771_ChIP-Seq_293T_Human	1.34161143
27	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.33267740
28	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.33117753
29	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.33105698
30	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.32722509
31	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.31979805
32	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.29986589
33	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.29164818
34	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.28551617
35	EP300_21415370_ChIP-Seq_HL-1_Mouse	1.28384162
36	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.27377825
37	CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.26895682
38	GF1_26923725_Chip-Seq_HPCs_Mouse	1.25962700
39	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.24482678
40	BCAT_22108803_ChIP-Seq_LS180_Human	1.22691106
41	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.21879083
42	SMC4_20622854_ChIP-Seq_HELA_Human	1.21296380
43	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.19801446
44	CBP_20019798_ChIP-Seq_JUKART_Human	1.18711411
45	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.18711411
46	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.17390152
47	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.16861283
48	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.15495387
49	CBP_21632823_ChIP-Seq_H3396_Human	1.14772166
50	* KDM2B_26808549_Chip-Seq_REH_Human	1.14404870
51	TCF4_18268006_ChIP-ChIP_LS174T_Human	1.14089600
52	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.13779723
53	SMAD4_21799915_ChIP-Seq_A2780_Human	1.13482271
54	GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse	1.12366243
55	CTCF_20526341_ChIP-Seq_ESCs_Human	1.07958768
56	* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	1.07629076
57	OCT1_27270436_Chip-Seq_PROSTATE_Human	1.06443328
58	RCOR3_21632747_ChIP-Seq_MESCs_Mouse	1.04636626
59	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.03591801
60	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.03536148
61	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.03482074
62	LUZP1_20508642_ChIP-Seq_ESCs_Mouse	1.03461372
63	NANOG_20526341_ChIP-Seq_ESCs_Human	1.03336425
64	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.03319085
65	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.03293083
66	* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.03161392
67	ERG_20517297_ChIP-Seq_VCAP_Human	1.02628433
68	P300_19829295_ChIP-Seq_ESCs_Human	1.01866029
69	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.01733727
70	AR_19668381_ChIP-Seq_PC3_Human	1.01625969
71	NCOR_22424771_ChIP-Seq_293T_Human	1.01524061
72	CTCF_27219007_Chip-Seq_Bcells_Human	1.01113310
73	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.00683619
74	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.00683619
75	GF1B_26923725_Chip-Seq_HPCs_Mouse	1.00168786
76	IKZF1_21737484_ChIP-ChIP_HCT116_Human	0.99689680
77	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.99637113
78	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.99493480
79	ZNF274_21170338_ChIP-Seq_K562_Hela	0.99355184
80	CMYC_18555785_Chip-Seq_ESCs_Mouse	0.98640916
81	* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	0.96701689
82	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.96628232
83	HTT_18923047_ChIP-ChIP_STHdh_Human	0.96627210
84	RXRA_24833708_ChIP-Seq_LIVER_Mouse	0.96594639
85	NFIB_24661679_ChIP-Seq_LUNG_Mouse	0.96171412
86	STAT3_23295773_ChIP-Seq_U87_Human	0.95243332
87	* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse	0.93951352
88	GATA3_21867929_ChIP-Seq_CD8_Mouse	0.92370139
89	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.92254925
90	CDX2_19796622_ChIP-Seq_MESCs_Mouse	0.91743975
91	MTF2_20144788_ChIP-Seq_MESCs_Mouse	0.91726264
92	RARB_27405468_Chip-Seq_BRAIN_Mouse	0.90502820
93	SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.90078979
94	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.89820025
95	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.89721324
96	TCF4_23295773_ChIP-Seq_U87_Human	0.89351590
97	ER_23166858_ChIP-Seq_MCF-7_Human	0.88921484
98	KAP1_22055183_ChIP-Seq_ESCs_Mouse	0.88152662
99	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	0.88092439
100	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.87564205

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005551_abnormal_eye_electrophysiolog	9.94846518
2	MP0005253_abnormal_eye_physiology	6.82727975
3	MP0006072_abnormal_retinal_apoptosis	6.35934680
4	MP0003950_abnormal_plasma_membrane	4.58374522
5	MP0005195_abnormal_posterior_eye	3.85749091
6	MP0001324_abnormal_eye_pigmentation	3.40316927
7	MP0005391_vision/eye_phenotype	3.31748068
8	MP0002638_abnormal_pupillary_reflex	2.91352834
9	MP0002090_abnormal_vision	2.79679359
10	MP0005423_abnormal_somatic_nervous	2.60093256
11	MP0002229_neurodegeneration	2.50517973
12	MP0005410_abnormal_fertilization	2.47243750
13	MP0001764_abnormal_homeostasis	2.44827174
14	MP0001986_abnormal_taste_sensitivity	2.23237409
15	MP0003011_delayed_dark_adaptation	10.3196767
16	MP0002752_abnormal_somatic_nervous	1.89465311
17	MP0002653_abnormal_ependyma_morphology	1.65413623
18	MP0004019_abnormal_vitamin_homeostasis	1.46668851
19	MP0004233_abnormal_muscle_weight	1.39829506
20	MP0002882_abnormal_neuron_morphology	1.28071196
21	MP0001984_abnormal_olfaction	1.24115861
22	MP0003698_abnormal_male_reproductive	1.04938575
23	MP0001502_abnormal_circadian_rhythm	1.02617921
24	MP0004782_abnormal_surfactant_physiolog	1.00824324
25	MP0004885_abnormal_endolymph	0.88087923
26	MP0005197_abnormal_uvea_morphology	0.84879282
27	MP0002127_abnormal_cardiovascular_syste	0.77317760
28	MP0005187_abnormal_penis_morphology	0.74772827
29	MP0001929_abnormal_gametogenesis	0.73982005
30	MP0002332_abnormal_exercise_endurance	0.72597776
31	MP0003634_abnormal_glial_cell	0.71643090
32	MP0002272_abnormal_nervous_system	0.64585475
33	MP0001486_abnormal_startle_reflex	0.64452300
34	MP0005499_abnormal_olfactory_system	0.64137166
35	MP0005394_taste/olfaction_phenotype	0.64137166
36	MP0006292_abnormal_olfactory_placode	0.61783237
37	MP0008004_abnormal_stomach_pH	0.61576456
38	MP0005376_homeostasis/metabolism_phenot	0.55017146
39	MP0004270_analgesia	0.54181268
40	MP0009046_muscle_twitch	0.54179161
41	MP0002161_abnormal_fertility/fecundity	0.51196615
42	MP0001963_abnormal_hearing_physiology	0.50100972
43	MP0008789_abnormal_olfactory_epithelium	0.49697321
44	MP0001286_abnormal_eye_development	0.42019586
45	MP0003252_abnormal_bile_duct	0.39722311
46	MP0004145_abnormal_muscle_electrophysio	0.37651772
47	MP0001661_extended_life_span	0.37562928
48	MP0003646_muscle_fatigue	0.37557728
49	MP0002734_abnormal_mechanical_nocicepti	0.37310096
50	MP0002064_seizures	0.36746716
51	MP0008875_abnormal_xenobiotic_pharmacok	0.35325011
52	MP0005365_abnormal_bile_salt	0.34003683
53	MP0002067_abnormal_sensory_capabilities	0.33733640
54	MP0008058_abnormal_DNA_repair	0.33417951
55	MP0002572_abnormal_emotion/affect_behav	0.31288919
56	MP0003045_fibrosis	0.31243288
57	MP0000026_abnormal_inner_ear	0.29687887
58	MP0002210_abnormal_sex_determination	0.29384018
59	MP0002928_abnormal_bile_duct	0.28949571
60	MP0003635_abnormal_synaptic_transmissio	0.28804800
61	MP0005620_abnormal_muscle_contractility	0.28629131
62	MP0004085_abnormal_heartbeat	0.28431255
63	MP0001968_abnormal_touch/_nociception	0.28351950
64	MP0002063_abnormal_learning/memory/cond	0.28268132
65	MP0010386_abnormal_urinary_bladder	0.28232751
66	MP0003880_abnormal_central_pattern	0.28042078
67	MP0004043_abnormal_pH_regulation	0.27620377
68	MP0004215_abnormal_myocardial_fiber	0.27543330
69	MP0005670_abnormal_white_adipose	0.26655931
70	MP0000465_gastrointestinal_hemorrhage	0.25049553
71	MP0000631_abnormal_neuroendocrine_gland	0.24942060
72	MP0004036_abnormal_muscle_relaxation	0.24839168
73	MP0001145_abnormal_male_reproductive	0.24580464
74	MP0008877_abnormal_DNA_methylation	0.23943759
75	MP0005076_abnormal_cell_differentiation	0.23701375
76	MP0002108_abnormal_muscle_morphology	0.23566686
77	MP0000653_abnormal_sex_gland	0.23457123
78	MP0005595_abnormal_vascular_smooth	0.21947983
79	MP0005085_abnormal_gallbladder_physiolo	0.19857800
80	MP0004924_abnormal_behavior	0.19083843
81	MP0005386_behavior/neurological_phenoty	0.19083843
82	MP0009745_abnormal_behavioral_response	0.18995543
83	MP0004142_abnormal_muscle_tone	0.18187439
84	MP0008569_lethality_at_weaning	0.18048962
85	MP0002102_abnormal_ear_morphology	0.17087190
86	MP0001177_atelectasis	0.16453379
87	MP0000749_muscle_degeneration	0.16277226
88	MP0004742_abnormal_vestibular_system	0.16250330
89	MP0002066_abnormal_motor_capabilities/c	0.15337730
90	MP0002152_abnormal_brain_morphology	0.14738506
91	MP0010329_abnormal_lipoprotein_level	0.14660014
92	MP0002971_abnormal_brown_adipose	0.13360665
93	MP0000751_myopathy	0.13312043
94	MP0005360_urolithiasis	0.13009953
95	MP0003943_abnormal_hepatobiliary_system	0.12830630
96	MP0001905_abnormal_dopamine_level	0.12793436
97	MP0005319_abnormal_enzyme/_coenzyme	0.12393717
98	MP0010368_abnormal_lymphatic_system	0.12290637
99	MP0002234_abnormal_pharynx_morphology	0.12180051
100	MP0005646_abnormal_pituitary_gland	0.11745775

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormal rod and cone electroretinograms (HP:0008323)	9.92468335
2	Dyschromatopsia (HP:0007641)	9.54915216
3	Pigmentary retinal degeneration (HP:0001146)	9.25126489
4	Chorioretinal atrophy (HP:0000533)	8.48645685
5	Attenuation of retinal blood vessels (HP:0007843)	7.74428900
6	Central scotoma (HP:0000603)	7.63555768
7	Abnormality of macular pigmentation (HP:0008002)	7.62471468
8	Pendular nystagmus (HP:0012043)	7.48760090
9	Scotoma (HP:0000575)	6.88413569
10	Decreased central vision (HP:0007663)	6.56664578
11	Abolished electroretinogram (ERG) (HP:0000550)	6.33345455
12	Photophobia (HP:0000613)	5.73254901
13	Type II diabetes mellitus (HP:0005978)	5.65072754
14	Vitreoretinal degeneration (HP:0000655)	5.24651117
15	Macular degeneration (HP:0000608)	4.97521648
16	Cone-rod dystrophy (HP:0000548)	4.73271774
17	Increased corneal curvature (HP:0100692)	4.69326288
18	Keratoconus (HP:0000563)	4.69326288
19	Choroideremia (HP:0001139)	4.61270335
20	Retinitis pigmentosa (HP:0000510)	4.55196092
21	Severe visual impairment (HP:0001141)	4.55048166
22	Constricted visual fields (HP:0001133)	4.20127615
23	Posterior subcapsular cataract (HP:0007787)	3.98848261
24	Decreased electroretinogram (ERG) amplitude (HP:0000654)	3.56158986
25	Retinal atrophy (HP:0001105)	2.89616129
26	Progressive visual loss (HP:0000529)	2.82152020
27	Gait imbalance (HP:0002141)	2.80013263
28	Congenital primary aphakia (HP:0007707)	2.79332664
29	Optic disc pallor (HP:0000543)	2.75672310
30	Medial flaring of the eyebrow (HP:0010747)	2.63717608
31	Subcapsular cataract (HP:0000523)	2.63503996
32	Congenital sensorineural hearing impairment (HP:0008527)	2.51668257
33	Wide nasal bridge (HP:0000431)	2.49462558
34	Nephrogenic diabetes insipidus (HP:0009806)	2.46873892
35	Poor coordination (HP:0002370)	2.14493158
36	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.06729148
37	Absent/shortened dynein arms (HP:0200106)	2.06729148
38	Congenital stationary night blindness (HP:0007642)	14.6304803
39	Bony spicule pigmentary retinopathy (HP:0007737)	11.5320231
40	Absent rod-and cone-mediated responses on ERG (HP:0007688)	10.0314317
41	Vaginal atresia (HP:0000148)	1.96998614
42	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.92465449
43	Genital tract atresia (HP:0001827)	1.89694530
44	True hermaphroditism (HP:0010459)	1.71197268
45	Aplasia/Hypoplasia of the lens (HP:0008063)	1.63999591
46	Optic atrophy (HP:0000648)	1.63760901
47	Pancreatic fibrosis (HP:0100732)	1.58905209
48	Interstitial pulmonary disease (HP:0006530)	1.54731250
49	Horizontal nystagmus (HP:0000666)	1.53088135
50	Abnormal respiratory motile cilium physiology (HP:0012261)	1.44858210
51	Recurrent sinusitis (HP:0011108)	1.43262218
52	Severe Myopia (HP:0011003)	1.41919385
53	Polar cataract (HP:0010696)	1.38372492
54	Abnormal respiratory epithelium morphology (HP:0012253)	1.34745988
55	Abnormal respiratory motile cilium morphology (HP:0005938)	1.34745988
56	Dysdiadochokinesis (HP:0002075)	1.32425707
57	Astigmatism (HP:0000483)	1.31040649
58	Abnormality of midbrain morphology (HP:0002418)	1.25925013
59	Molar tooth sign on MRI (HP:0002419)	1.25925013
60	Cystic liver disease (HP:0006706)	1.24479075
61	Nephronophthisis (HP:0000090)	1.22837769
62	Pancreatic cysts (HP:0001737)	1.22615162
63	Cerebellar dysplasia (HP:0007033)	1.21448238
64	Abnormal ciliary motility (HP:0012262)	1.17700791
65	Broad foot (HP:0001769)	1.13639914
66	Retinal detachment (HP:0000541)	1.12385392
67	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.10027277
68	Left ventricular hypertrophy (HP:0001712)	1.10023475
69	Decreased testicular size (HP:0008734)	1.09614633
70	Rhinitis (HP:0012384)	1.08978964
71	Chronic hepatic failure (HP:0100626)	1.07845074
72	Epileptic encephalopathy (HP:0200134)	1.07045023
73	Specific learning disability (HP:0001328)	1.06222226
74	Asthma (HP:0002099)	1.04029019
75	Abnormality of the renal medulla (HP:0100957)	1.03860219
76	Abnormality of the fovea (HP:0000493)	1.03281084
77	Chronic bronchitis (HP:0004469)	1.02676531
78	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.01158791
79	Hypoplasia of the fovea (HP:0007750)	1.01158791
80	Progressive cerebellar ataxia (HP:0002073)	0.98141715
81	Chorioretinal coloboma (HP:0000567)	0.93859839
82	Postaxial hand polydactyly (HP:0001162)	0.92895368
83	Partial agenesis of the corpus callosum (HP:0001338)	0.92877518
84	Congenital hepatic fibrosis (HP:0002612)	0.92191869
85	Truncal ataxia (HP:0002078)	0.90963736
86	Tubulointerstitial nephritis (HP:0001970)	0.90882495
87	Aplasia/Hypoplasia of the macula (HP:0008059)	0.88739787
88	Sclerocornea (HP:0000647)	0.87193504
89	Recurrent otitis media (HP:0000403)	0.86815275
90	Hypodontia (HP:0000668)	0.83892453
91	Postaxial foot polydactyly (HP:0001830)	0.83606401
92	Dental crowding (HP:0000678)	0.83026330
93	Febrile seizures (HP:0002373)	0.82878141
94	Infertility (HP:0000789)	0.82764092
95	Aplasia/Hypoplasia affecting the retina (HP:0008061)	0.81541704
96	Cholecystitis (HP:0001082)	0.80944063
97	Abnormal gallbladder physiology (HP:0012438)	0.80944063
98	Hypermetropia (HP:0000540)	0.79717742
99	Furrowed tongue (HP:0000221)	0.79329799
100	Abnormality of dental color (HP:0011073)	0.73669013

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	GRK1	9.34829555
2	PBK	7.66115919
3	PDK4	3.22718336
4	PDK3	3.22718336
5	PINK1	3.08343075
6	PDK2	2.83220040
7	ICK	2.33405077
8	PRKD3	2.27330995
9	IRAK2	2.23135084
10	STK38	1.69392071
11	CCNB1	1.56491858
12	ADRBK1	1.38784248
13	TESK1	1.35250637
14	MAPK7	1.29295228
15	INSRR	1.27328841
16	PNCK	1.17335064
17	CAMK1G	1.15027088
18	TAOK3	1.14986435
19	DYRK1B	1.13455982
20	SGK494	1.11183655
21	SGK223	1.11183655
22	AKT3	1.08425995
23	MAPK12	1.06927283
24	PRKCZ	0.98280705
25	TTK	0.96166406
26	SIK2	0.95991199
27	SGK2	0.95812042
28	WNK4	0.95544043
29	CAMK1D	0.92480261
30	RPS6KA4	0.92355389
31	MARK1	0.90075623
32	WNK1	0.89810837
33	NEK2	0.89395273
34	PRKAA1	0.84082415
35	CDK12	0.83786449
36	STK39	0.83170504
37	BRD4	0.83013278
38	STK38L	0.81625367
39	LMTK2	0.81379476
40	NEK1	0.79773120
41	CSNK1D	0.78705451
42	NEK6	0.71428601
43	SGK3	0.70896816
44	MAP3K10	0.70497710
45	CDK3	0.70063388
46	DYRK1A	0.65227082
47	FRK	0.64644120
48	PRKAA2	0.62958957
49	PHKG2	0.62461137
50	PHKG1	0.62461137
51	MAP3K4	0.62309218
52	HIPK2	0.62003304
53	PRKACG	0.60345502
54	MYLK	0.58471836
55	PAK6	0.58419964
56	PRKCB	0.55155325
57	CAMKK1	0.52540597
58	PRKCH	0.52198929
59	PRKCG	0.51437215
60	CAMK2D	0.49640006
61	ERBB2	0.48056248
62	PTK2B	0.47340223
63	PKN1	0.47013982
64	FGFR2	0.46319317
65	PDK1	0.45818019
66	RPS6KA3	0.43266379
67	CHEK2	0.43009555
68	IRAK1	0.42792941
69	PLK3	0.40621177
70	GSK3B	0.37465871
71	LATS1	0.36591672
72	FES	0.35576679
73	PRKDC	0.33892085
74	CAMK1	0.33582978
75	MAP2K7	0.33349560
76	CAMK2A	0.32676656
77	PRKD2	0.32581807
78	CASK	0.31907096
79	PRKACA	0.31724684
80	GRK5	0.30335013
81	RPS6KB1	0.29904658
82	PLK2	0.29818760
83	SGK1	0.28847092
84	CHEK1	0.27955123
85	AKT2	0.27179472
86	MAPK9	0.26407374
87	PRKCA	0.24939432
88	CDK1	0.24363157
89	MAPK10	0.24324857
90	MAPK14	0.23671413
91	PDPK1	0.22756827
92	SIK1	0.21924536
93	EPHA3	0.21652191
94	ATM	0.21009134
95	STK11	0.20993698
96	CDK5	0.20234267
97	MAP3K7	0.16698000
98	ATR	0.16448821
99	MKNK2	0.15855027
100	CSNK1E	0.15601081

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phototransduction_Homo sapiens_hsa04744	15.8925661
2	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.45568642
3	Olfactory transduction_Homo sapiens_hsa04740	1.25871089
4	Retinol metabolism_Homo sapiens_hsa00830	1.03173817
5	GABAergic synapse_Homo sapiens_hsa04727	1.00634541
6	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.96366767
7	Circadian rhythm_Homo sapiens_hsa04710	0.86502916
8	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.78049023
9	Caffeine metabolism_Homo sapiens_hsa00232	0.77360714
10	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.74054463
11	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.72829953
12	Morphine addiction_Homo sapiens_hsa05032	0.71393989
13	ABC transporters_Homo sapiens_hsa02010	0.71298969
14	Cholinergic synapse_Homo sapiens_hsa04725	0.70963370
15	Circadian entrainment_Homo sapiens_hsa04713	0.68120704
16	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.66778496
17	Dopaminergic synapse_Homo sapiens_hsa04728	0.62981069
18	Glutamatergic synapse_Homo sapiens_hsa04724	0.62636455
19	Purine metabolism_Homo sapiens_hsa00230	0.61974429
20	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.60137947
21	Glycerolipid metabolism_Homo sapiens_hsa00561	0.52969569
22	Insulin secretion_Homo sapiens_hsa04911	0.49996000
23	Serotonergic synapse_Homo sapiens_hsa04726	0.49941671
24	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.48019574
25	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.47808927
26	Nicotine addiction_Homo sapiens_hsa05033	0.47629081
27	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.46536283
28	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.45178194
29	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.42777946
30	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.42578540
31	Pyruvate metabolism_Homo sapiens_hsa00620	0.41798627
32	Glucagon signaling pathway_Homo sapiens_hsa04922	0.41488129
33	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.40870445
34	Linoleic acid metabolism_Homo sapiens_hsa00591	0.40753722
35	Fatty acid elongation_Homo sapiens_hsa00062	0.40631187
36	Cardiac muscle contraction_Homo sapiens_hsa04260	0.40610265
37	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.39612106
38	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.37699917
39	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.37626262
40	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.37578171
41	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.36477680
42	Arginine biosynthesis_Homo sapiens_hsa00220	0.31811866
43	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.31716001
44	Renin secretion_Homo sapiens_hsa04924	0.28394787
45	Nitrogen metabolism_Homo sapiens_hsa00910	0.27943673
46	Fat digestion and absorption_Homo sapiens_hsa04975	0.27807036
47	Mineral absorption_Homo sapiens_hsa04978	0.27317922
48	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.26980151
49	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.26978924
50	cAMP signaling pathway_Homo sapiens_hsa04024	0.26616595
51	Bile secretion_Homo sapiens_hsa04976	0.25381962
52	Salivary secretion_Homo sapiens_hsa04970	0.23900943
53	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.23881561
54	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.22706846
55	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.22661203
56	Collecting duct acid secretion_Homo sapiens_hsa04966	0.21965099
57	Carbon metabolism_Homo sapiens_hsa01200	0.21307844
58	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.20557278
59	Fatty acid metabolism_Homo sapiens_hsa01212	0.20442442
60	Gastric acid secretion_Homo sapiens_hsa04971	0.20142366
61	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.19997373
62	Galactose metabolism_Homo sapiens_hsa00052	0.19772886
63	Pentose phosphate pathway_Homo sapiens_hsa00030	0.19242442
64	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.19129030
65	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.19066482
66	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.18776792
67	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.17985242
68	Calcium signaling pathway_Homo sapiens_hsa04020	0.17878504
69	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.17505812
70	Amphetamine addiction_Homo sapiens_hsa05031	0.17463803
71	Ether lipid metabolism_Homo sapiens_hsa00565	0.17331226
72	PPAR signaling pathway_Homo sapiens_hsa03320	0.16780426
73	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.16727744
74	AMPK signaling pathway_Homo sapiens_hsa04152	0.15738628
75	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.15553633
76	Alcoholism_Homo sapiens_hsa05034	0.14737795
77	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.14524942
78	mRNA surveillance pathway_Homo sapiens_hsa03015	0.14044136
79	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.13500876
80	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.13304732
81	Lysine degradation_Homo sapiens_hsa00310	0.12510789
82	Cocaine addiction_Homo sapiens_hsa05030	0.12397226
83	mTOR signaling pathway_Homo sapiens_hsa04150	0.12055904
84	Pancreatic secretion_Homo sapiens_hsa04972	0.11604233
85	Fatty acid degradation_Homo sapiens_hsa00071	0.10744024
86	Long-term potentiation_Homo sapiens_hsa04720	0.10146201
87	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.09511145
88	Propanoate metabolism_Homo sapiens_hsa00640	0.09234852
89	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.08743135
90	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.08704059
91	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.08306275
92	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.07972610
93	Taste transduction_Homo sapiens_hsa04742	0.07750218
94	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.07630406
95	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.07260456
96	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.06969136
97	Type II diabetes mellitus_Homo sapiens_hsa04930	0.06328060
98	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.06263144
99	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.05857756
100	Oocyte meiosis_Homo sapiens_hsa04114	0.04752670

FABP12

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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