FABP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The intracellular fatty acid-binding proteins (FABPs) belong to a multigene family with nearly twenty identified members. FABPs are divided into at least three distinct types, namely the hepatic-, intestinal- and cardiac-type. They form 14-15 kDa proteins and are thought to participate in the uptake, intracellular metabolism and/or transport of long-chain fatty acids. They may also be responsible in the modulation of cell growth and proliferation. Intestinal fatty acid-binding protein 2 gene contains four exons and is an abundant cytosolic protein in small intestine epithelial cells. This gene has a polymorphism at codon 54 that identified an alanine-encoding allele and a threonine-encoding allele. Thr-54 protein is associated with increased fat oxidation and insulin resistance. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1intestinal absorption (GO:0050892)9.76535201
2intestinal cholesterol absorption (GO:0030299)9.63170801
3angiotensin maturation (GO:0002003)8.41685171
4regulation of guanylate cyclase activity (GO:0031282)8.00327193
5triglyceride-rich lipoprotein particle remodeling (GO:0034370)7.38168976
6NADH metabolic process (GO:0006734)6.79426926
7fat-soluble vitamin biosynthetic process (GO:0042362)6.53338819
8phospholipid efflux (GO:0033700)6.49875584
9positive regulation of guanylate cyclase activity (GO:0031284)6.47152582
10regulation of cholesterol esterification (GO:0010872)6.44156252
11regulation of triglyceride catabolic process (GO:0010896)6.16818616
12regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)6.10059863
13flavonoid metabolic process (GO:0009812)5.85265528
14drug catabolic process (GO:0042737)5.74560632
15positive regulation of lipoprotein lipase activity (GO:0051006)5.72801237
16positive regulation of triglyceride lipase activity (GO:0061365)5.72801237
17plasma lipoprotein particle assembly (GO:0034377)5.71717990
18fructose metabolic process (GO:0006000)5.41057525
19regulation of cellular extravasation (GO:0002691)5.40962257
20regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)5.39360403
21endocrine process (GO:0050886)5.39360403
22regulation of systemic arterial blood pressure by hormone (GO:0001990)5.39360403
23vitamin A metabolic process (GO:0006776)5.37395135
24cholesterol efflux (GO:0033344)5.34936992
25protein-lipid complex assembly (GO:0065005)5.32610494
26high-density lipoprotein particle remodeling (GO:0034375)5.29869815
27regulation of bile acid biosynthetic process (GO:0070857)5.23511020
28reverse cholesterol transport (GO:0043691)5.22872935
29bile acid and bile salt transport (GO:0015721)5.06727542
30negative regulation of sterol transport (GO:0032372)5.05992535
31negative regulation of cholesterol transport (GO:0032375)5.05992535
32very-low-density lipoprotein particle assembly (GO:0034379)5.05551445
33lipoprotein metabolic process (GO:0042157)4.99695219
34virion attachment to host cell (GO:0019062)4.88195335
35adhesion of symbiont to host cell (GO:0044650)4.88195335
36regulation of cGMP biosynthetic process (GO:0030826)4.85864778
37regulation of systemic arterial blood pressure (GO:0003073)4.85823640
38plasma lipoprotein particle remodeling (GO:0034369)4.78055131
39protein-lipid complex remodeling (GO:0034368)4.78055131
40macromolecular complex remodeling (GO:0034367)4.78055131
41cholesterol homeostasis (GO:0042632)4.59404439
42sterol homeostasis (GO:0055092)4.53696793
43hormone catabolic process (GO:0042447)4.52373327
44urea metabolic process (GO:0019627)4.51556684
45urea cycle (GO:0000050)4.51556684
46receptor guanylyl cyclase signaling pathway (GO:0007168)4.46916185
47antibacterial humoral response (GO:0019731)4.32719355
48purine ribonucleoside bisphosphate metabolic process (GO:0034035)4.23698676
493-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)4.23698676
50adhesion of symbiont to host (GO:0044406)4.22157568
51glycolipid catabolic process (GO:0019377)4.21080577
52sterol transport (GO:0015918)4.20338359
53cholesterol transport (GO:0030301)4.20338359
54positive regulation of fatty acid biosynthetic process (GO:0045723)4.19093439
55antimicrobial humoral response (GO:0019730)4.15568548
56glycosphingolipid catabolic process (GO:0046479)4.13704300
57plasma lipoprotein particle organization (GO:0071827)4.13462691
58digestive system process (GO:0022600)4.11722886
59triglyceride homeostasis (GO:0070328)4.10380667
60acylglycerol homeostasis (GO:0055090)4.10380667
61nitrogen cycle metabolic process (GO:0071941)4.08660175
62* digestion (GO:0007586)4.07776728
63regulation of vitamin metabolic process (GO:0030656)4.05710540
64positive regulation of lipid catabolic process (GO:0050996)4.05649746
65regulation of cGMP metabolic process (GO:0030823)4.05092853
66protein-lipid complex subunit organization (GO:0071825)4.00965132
67positive regulation of glycoprotein biosynthetic process (GO:0010560)4.00833604
68regulation of cholesterol homeostasis (GO:2000188)3.99175974
69renal system process involved in regulation of blood volume (GO:0001977)3.98139547
70homocysteine metabolic process (GO:0050667)3.93239716
71modified amino acid transport (GO:0072337)3.91320910
72glucose 6-phosphate metabolic process (GO:0051156)3.88935401
73fat-soluble vitamin metabolic process (GO:0006775)3.87621065
74positive regulation of triglyceride metabolic process (GO:0090208)3.86496384
75alpha-linolenic acid metabolic process (GO:0036109)3.84131836
76mRNA modification (GO:0016556)3.77830959
77positive regulation of cGMP biosynthetic process (GO:0030828)3.74787937
78positive regulation of pseudopodium assembly (GO:0031274)3.74725975
79phospholipid homeostasis (GO:0055091)3.74227497
80cellular response to nitric oxide (GO:0071732)3.72352160
81plasma lipoprotein particle clearance (GO:0034381)3.70732332
82maintenance of gastrointestinal epithelium (GO:0030277)3.69558366
83drug metabolic process (GO:0017144)3.68966182
84fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.68662710
85arginine metabolic process (GO:0006525)3.66497782
86cysteine metabolic process (GO:0006534)3.66239250
87cellular glucuronidation (GO:0052695)3.64226466
88UDP-N-acetylglucosamine metabolic process (GO:0006047)3.63791611
89vitamin transmembrane transport (GO:0035461)3.63593719
90L-phenylalanine catabolic process (GO:0006559)3.62724032
91erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.62724032
92vitamin transport (GO:0051180)3.62466642
93cytidine deamination (GO:0009972)3.62434715
94cytidine metabolic process (GO:0046087)3.62434715
95cytidine catabolic process (GO:0006216)3.62434715
96diacylglycerol metabolic process (GO:0046339)3.62148859
97lipoprotein transport (GO:0042953)3.61494157
98drinking behavior (GO:0042756)3.58943070
99erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.58478053
100L-phenylalanine metabolic process (GO:0006558)3.58478053
101actin filament depolymerization (GO:0030042)3.54333517
102positive regulation of glycoprotein metabolic process (GO:1903020)3.53912406
103killing of cells of other organism (GO:0031640)3.53723184
104disruption of cells of other organism (GO:0044364)3.53723184
105bundle of His cell to Purkinje myocyte communication (GO:0086069)3.52811830
106exogenous drug catabolic process (GO:0042738)3.52073189
107bile acid metabolic process (GO:0008206)3.51317011
108cGMP biosynthetic process (GO:0006182)3.47174310
109sulfur amino acid catabolic process (GO:0000098)3.46847142
110lipid homeostasis (GO:0055088)3.45437743
111glutamine family amino acid biosynthetic process (GO:0009084)3.41697689
112ceramide catabolic process (GO:0046514)3.40106444
113vitamin biosynthetic process (GO:0009110)3.40044429
114regulation of cholesterol transport (GO:0032374)3.37810932
115regulation of sterol transport (GO:0032371)3.37810932
116drug transmembrane transport (GO:0006855)3.37514260
117midgut development (GO:0007494)3.36834813
118response to nitric oxide (GO:0071731)3.35020839
119glycosylceramide metabolic process (GO:0006677)3.34998708
120regulation of pseudopodium assembly (GO:0031272)3.34680849
121sulfate transmembrane transport (GO:1902358)3.33210152
122pyrimidine ribonucleoside catabolic process (GO:0046133)3.32489900
123drug transport (GO:0015893)3.27454680
124antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.26779759
125peptide catabolic process (GO:0043171)3.26644895
126peptide hormone processing (GO:0016486)3.25616293
127aromatic amino acid family catabolic process (GO:0009074)3.25389463
128glucuronate metabolic process (GO:0019585)3.25082451
129uronic acid metabolic process (GO:0006063)3.25082451
130epoxygenase P450 pathway (GO:0019373)3.24774421
131regulation of protein glycosylation (GO:0060049)3.24730079
132positive regulation of cGMP metabolic process (GO:0030825)3.23552437
133sulfation (GO:0051923)3.23399924
134glycerol metabolic process (GO:0006071)3.22355408
135cellular response to reactive nitrogen species (GO:1902170)3.18073225
136sphingomyelin metabolic process (GO:0006684)3.15387321
137cobalamin metabolic process (GO:0009235)3.14998505
138sphingolipid catabolic process (GO:0030149)3.13610389
139nucleoside diphosphate biosynthetic process (GO:0009133)3.13136597
140amino-acid betaine metabolic process (GO:0006577)3.12260921
141antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.09877074
142transcytosis (GO:0045056)3.06409203
143vitamin D metabolic process (GO:0042359)3.05485047
144negative regulation of digestive system process (GO:0060457)3.04954619
145cellular ketone body metabolic process (GO:0046950)3.04954369
146phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.03615313
147nucleobase catabolic process (GO:0046113)3.02739306
148alkaloid metabolic process (GO:0009820)3.02645923
149bile acid biosynthetic process (GO:0006699)3.01440427
150response to phenylpropanoid (GO:0080184)2.98604091
151regulation of triglyceride metabolic process (GO:0090207)2.98578226
152kynurenine metabolic process (GO:0070189)2.97331727
153lysine catabolic process (GO:0006554)2.96847066
154lysine metabolic process (GO:0006553)2.96847066
155heme transport (GO:0015886)2.96350403
156regulation of lipoprotein metabolic process (GO:0050746)2.95203172

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.78342570
2TP63_17297297_ChIP-ChIP_HaCaT_Human5.77211578
3RXR_22158963_ChIP-Seq_LIVER_Mouse5.67282412
4PPARA_22158963_ChIP-Seq_LIVER_Mouse5.38092637
5* LXR_22158963_ChIP-Seq_LIVER_Mouse4.83126874
6EGR1_23403033_ChIP-Seq_LIVER_Mouse4.50893497
7CDX2_20551321_ChIP-Seq_CACO-2_Human4.04615706
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.79252143
9HNF4A_19761587_ChIP-ChIP_CACO-2_Human3.21850399
10FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.13519289
11IRF8_22096565_ChIP-ChIP_GC-B_Human3.01907777
12SOX2_27498859_Chip-Seq_STOMACH_Mouse3.01362622
13BP1_19119308_ChIP-ChIP_Hs578T_Human2.91429261
14CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.90717751
15NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.87735211
16GATA4_25053715_ChIP-Seq_YYC3_Human2.55184389
17TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.22307081
18GATA6_25053715_ChIP-Seq_YYC3_Human2.05867557
19SOX2_20726797_ChIP-Seq_SW620_Human1.97085626
20TRIM28_21343339_ChIP-Seq_HEK293_Human1.95419091
21CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.78701412
22STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.74923286
23PPAR_26484153_Chip-Seq_NCI-H1993_Human1.69066803
24IRF8_21731497_ChIP-ChIP_J774_Mouse1.68396296
25IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.65187013
26HNF4A_19822575_ChIP-Seq_HepG2_Human1.63564135
27CDX2_19796622_ChIP-Seq_MESCs_Mouse1.62145744
28CLOCK_20551151_ChIP-Seq_293T_Human1.60778560
29FOXA2_19822575_ChIP-Seq_HepG2_Human1.54975190
30GATA1_22025678_ChIP-Seq_K562_Human1.47343456
31NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.42585348
32TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.32539850
33GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.32467457
34CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.31659176
35THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.29588448
36STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.28294664
37ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.27823447
38ESR2_21235772_ChIP-Seq_MCF-7_Human1.26797500
39* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.25304449
40SRY_22984422_ChIP-ChIP_TESTIS_Rat1.24890374
41RXR_22108803_ChIP-Seq_LS180_Human1.24660082
42FOXO3_23340844_ChIP-Seq_DLD1_Human1.21208833
43CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.18827918
44RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.18713064
45GATA2_19941826_ChIP-Seq_K562_Human1.17128214
46TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13922073
47VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.12843258
48FOXA1_21572438_ChIP-Seq_LNCaP_Human1.11523981
49VDR_22108803_ChIP-Seq_LS180_Human1.09029585
50* NANOG_20526341_ChIP-Seq_ESCs_Human1.08527734
51FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.06747963
52SALL4_18804426_ChIP-ChIP_XEN_Mouse1.05827160
53MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.05470696
54TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.04181035
55KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.04078634
56KLF5_25053715_ChIP-Seq_YYC3_Human1.03245673
57AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.02907666
58VDR_24787735_ChIP-Seq_THP-1_Human1.02684865
59CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.02227463
60KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.01900844
61RUNX1_27514584_Chip-Seq_MCF-7_Human1.01897415
62RACK7_27058665_Chip-Seq_MCF-7_Human1.01481301
63NR3C1_21868756_ChIP-Seq_MCF10A_Human1.01048811
64FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.99161546
65ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.98790283
66TCF4_18268006_ChIP-ChIP_LS174T_Human0.98549849
67SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.97592989
68GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.96615243
69* CEBPB_22108803_ChIP-Seq_LS180_Human0.96450195
70ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.96087050
71SA1_27219007_Chip-Seq_Bcells_Human0.95620366
72EGR1_19032775_ChIP-ChIP_M12_Human0.94796215
73ESR1_20079471_ChIP-ChIP_T-47D_Human0.93758748
74PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.93632551
75GATA2_22383799_ChIP-Seq_G1ME_Mouse0.93055323
76ATF3_27146783_Chip-Seq_COLON_Human0.92021447
77CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.88775756
78GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.88640786
79HTT_18923047_ChIP-ChIP_STHdh_Human0.88249463
80Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.87498466
81P63_26484246_Chip-Seq_KERATINOCYTES_Human0.86232390
82STAT1_20625510_ChIP-Seq_HELA_Human0.86074015
83JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.84960455
84EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.84416610
85EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.84411628
86ZNF217_24962896_ChIP-Seq_MCF-7_Human0.83904834
87IKZF1_21737484_ChIP-ChIP_HCT116_Human0.83865380
88AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.83549888
89ZNF263_19887448_ChIP-Seq_K562_Human0.83125091
90ETV2_25802403_ChIP-Seq_MESCs_Mouse0.82942522
91SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.82589337
92CREB1_26743006_Chip-Seq_LNCaP_Human0.82524455
93TAF2_19829295_ChIP-Seq_ESCs_Human0.82458929
94ESR1_21235772_ChIP-Seq_MCF-7_Human0.82324155
95TCF4_22108803_ChIP-Seq_LS180_Human0.82103355
96HIF1A_21447827_ChIP-Seq_MCF-7_Human0.80323676
97KAP1_22055183_ChIP-Seq_ESCs_Mouse0.79932324
98PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.79835500
99RARA_24833708_ChIP-Seq_LIVER_Mouse0.79818624
100HNFA_21074721_ChIP-Seq_CACO-2_Human0.79462175
101PRDM14_20953172_ChIP-Seq_ESCs_Human0.79071314
102NCOR_22424771_ChIP-Seq_293T_Human0.79046997
103GATA1_19941826_ChIP-Seq_K562_Human0.78195828
104FOXA1_25552417_ChIP-Seq_VCAP_Human0.77312135
105PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.77115439
106FOXA1_25329375_ChIP-Seq_VCAP_Human0.75120946
107FOXA1_27270436_Chip-Seq_PROSTATE_Human0.75120946
108MYC_19829295_ChIP-Seq_ESCs_Human0.74637275
109FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.74210254
110SOX2_22085726_ChIP-Seq_NPCs_Mouse0.73804131
111PCGF2_27294783_Chip-Seq_NPCs_Mouse0.73640560
112* LXR_22292898_ChIP-Seq_THP-1_Human0.73539793
113* IRF8_27001747_Chip-Seq_BMDM_Mouse0.73375472
114SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.73358379
115NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.73227440
116FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.72987025
117RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.72195744
118STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.71405240
119TCF3_18692474_ChIP-Seq_MEFs_Mouse0.70819361
120RAD21_21589869_ChIP-Seq_MESCs_Mouse0.70647399
121MYC_19915707_ChIP-ChIP_AK7_Human0.69052845
122GATA3_24758297_ChIP-Seq_MCF-7_Human0.68885643
123CDX2_22108803_ChIP-Seq_LS180_Human0.67781605
124STAT1_17558387_ChIP-Seq_HELA_Human0.67303207
125ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.66260368
126JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.66039451
127RARG_19884340_ChIP-ChIP_MEFs_Mouse0.65816556
128TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.65785524
129SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.65365532
130CTCF_27219007_Chip-Seq_Bcells_Human0.65337547
131BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.65039479
132NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.64750139
133BCAT_22108803_ChIP-Seq_LS180_Human0.64364846
134TP63_23658742_ChIP-Seq_EP156T_Human0.63764047
135BCOR_27268052_Chip-Seq_Bcells_Human0.63340370
136SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.63083823
137PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.62719567
138PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.60490386
139BCL6_27268052_Chip-Seq_Bcells_Human0.60237061

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis9.73295099
2MP0002139_abnormal_hepatobiliary_system6.13642905
3MP0001666_abnormal_nutrient_absorption5.35796776
4MP0005085_abnormal_gallbladder_physiolo5.06556104
5MP0009840_abnormal_foam_cell4.50672511
6MP0008875_abnormal_xenobiotic_pharmacok4.27651689
7MP0005365_abnormal_bile_salt4.16532013
8MP0003252_abnormal_bile_duct3.87309927
9MP0010329_abnormal_lipoprotein_level3.36885802
10MP0003183_abnormal_peptide_metabolism2.87674896
11MP0010234_abnormal_vibrissa_follicle2.66502244
12MP0003806_abnormal_nucleotide_metabolis2.49111766
13MP0004264_abnormal_extraembryonic_tissu2.43777956
14MP0004019_abnormal_vitamin_homeostasis2.29894057
15MP0002822_catalepsy2.25370576
16MP0000462_abnormal_digestive_system2.07219239
17MP0003191_abnormal_cellular_cholesterol2.02257207
18MP0005332_abnormal_amino_acid1.91480327
19MP0005409_darkened_coat_color1.88579193
20MP0009697_abnormal_copulation1.70123826
21MP0003866_abnormal_defecation1.69203403
22MP0005084_abnormal_gallbladder_morpholo1.67697822
23MP0000609_abnormal_liver_physiology1.58492226
24* MP0002118_abnormal_lipid_homeostasis1.54100242
25MP0004147_increased_porphyrin_level1.47686508
26MP0001501_abnormal_sleep_pattern1.36176171
27MP0003705_abnormal_hypodermis_morpholog1.35696817
28MP0005670_abnormal_white_adipose1.35117813
29MP0003878_abnormal_ear_physiology1.35015944
30MP0005377_hearing/vestibular/ear_phenot1.35015944
31MP0002254_reproductive_system_inflammat1.30947221
32MP0001188_hyperpigmentation1.30601468
33MP0003868_abnormal_feces_composition1.27362163
34MP0009643_abnormal_urine_homeostasis1.25830004
35MP0000678_abnormal_parathyroid_gland1.25544796
36MP0010155_abnormal_intestine_physiology1.23505144
37MP0001663_abnormal_digestive_system1.22320390
38MP0005381_digestive/alimentary_phenotyp1.21502133
39MP0000538_abnormal_urinary_bladder1.21065508
40MP0005319_abnormal_enzyme/_coenzyme1.20182149
41MP0003300_gastrointestinal_ulcer1.17370987
42MP0001664_abnormal_digestion1.12617871
43MP0005451_abnormal_body_composition1.12191093
44MP0004858_abnormal_nervous_system1.11119980
45MP0004043_abnormal_pH_regulation1.10442731
46MP0001764_abnormal_homeostasis1.10392679
47MP0004270_analgesia1.09142713
48MP0001873_stomach_inflammation1.04060842
49MP0005535_abnormal_body_temperature1.03686645
50MP0004782_abnormal_surfactant_physiolog1.03610633
51MP0005083_abnormal_biliary_tract1.03344350
52MP0002876_abnormal_thyroid_physiology1.03215992
53MP0000537_abnormal_urethra_morphology1.01658373
54MP0000477_abnormal_intestine_morphology1.01361462
55MP0002796_impaired_skin_barrier0.99368915
56MP0009379_abnormal_foot_pigmentation0.98474438
57MP0005584_abnormal_enzyme/coenzyme_acti0.96708137
58* MP0005448_abnormal_energy_balance0.94638652
59MP0002396_abnormal_hematopoietic_system0.93688274
60MP0005167_abnormal_blood-brain_barrier0.91140171
61MP0005636_abnormal_mineral_homeostasis0.81533120
62MP0003718_maternal_effect0.80702034
63MP0009785_altered_susceptibility_to0.80120112
64MP0010352_gastrointestinal_tract_polyps0.79392431
65MP0002138_abnormal_hepatobiliary_system0.79352113
66MP0003724_increased_susceptibility_to0.77535360
67MP0006054_spinal_hemorrhage0.75349154
68MP0001835_abnormal_antigen_presentation0.74724039
69MP0000604_amyloidosis0.73088274
70MP0002089_abnormal_postnatal_growth/wei0.72844029
71MP0008872_abnormal_physiological_respon0.72543375
72MP0005266_abnormal_metabolism0.72491966
73MP0002166_altered_tumor_susceptibility0.72487335
74MP0000465_gastrointestinal_hemorrhage0.71698091
75MP0001485_abnormal_pinna_reflex0.70187941
76MP0005174_abnormal_tail_pigmentation0.69707241
77* MP0009642_abnormal_blood_homeostasis0.69400196
78MP0009053_abnormal_anal_canal0.68329903
79MP0000490_abnormal_crypts_of0.67480501
80MP0005166_decreased_susceptibility_to0.66109560
81MP0009764_decreased_sensitivity_to0.65019125
82MP0009765_abnormal_xenobiotic_induced0.64548475
83MP0004947_skin_inflammation0.63829813
84MP0005376_homeostasis/metabolism_phenot0.63640070
85MP0003656_abnormal_erythrocyte_physiolo0.62658160
86MP0005025_abnormal_response_to0.61691101
87MP0001790_abnormal_immune_system0.60501865
88MP0005387_immune_system_phenotype0.60501865
89MP0006082_CNS_inflammation0.60069858
90* MP0000598_abnormal_liver_morphology0.59984608
91MP0000015_abnormal_ear_pigmentation0.59480922
92MP0003195_calcinosis0.59021725
93MP0002136_abnormal_kidney_physiology0.57851496
94MP0009384_cardiac_valve_regurgitation0.56171786
95MP0008469_abnormal_protein_level0.56081341
96MP0003638_abnormal_response/metabolism_0.54494058
97MP0000467_abnormal_esophagus_morphology0.54258718
98MP0001765_abnormal_ion_homeostasis0.54135942
99MP0005501_abnormal_skin_physiology0.52300046
100MP0002971_abnormal_brown_adipose0.51647664
101MP0002148_abnormal_hypersensitivity_rea0.49090050
102MP0001849_ear_inflammation0.47328082
103MP0003453_abnormal_keratinocyte_physiol0.47216946
104MP0002098_abnormal_vibrissa_morphology0.46437961
105MP0005671_abnormal_response_to0.46114064
106MP0008873_increased_physiological_sensi0.46056348
107MP0001756_abnormal_urination0.45989776
108MP0002006_tumorigenesis0.45813493
109MP0009333_abnormal_splenocyte_physiolog0.45510058
110* MP0002078_abnormal_glucose_homeostasis0.45483592
111MP0009115_abnormal_fat_cell0.44898562
112MP0010678_abnormal_skin_adnexa0.44378241
113MP0003436_decreased_susceptibility_to0.44298235
114MP0003283_abnormal_digestive_organ0.44188055
115MP0004484_altered_response_of0.44165009
116MP0000230_abnormal_systemic_arterial0.43600681
117MP0009780_abnormal_chondrocyte_physiolo0.43579405
118MP0005666_abnormal_adipose_tissue0.43455106
119MP0009763_increased_sensitivity_to0.43454641
120* MP0003953_abnormal_hormone_level0.43052121
121MP0001800_abnormal_humoral_immune0.42335646
122MP0003879_abnormal_hair_cell0.40438985
123MP0005464_abnormal_platelet_physiology0.39171761
124MP0005408_hypopigmentation0.38979792
125MP0001881_abnormal_mammary_gland0.36811718
126MP0001216_abnormal_epidermal_layer0.35467894
127MP0000249_abnormal_blood_vessel0.34823247
128MP0001845_abnormal_inflammatory_respons0.33599955
129MP0000427_abnormal_hair_cycle0.32775180
130MP0006138_congestive_heart_failure0.31098207
131MP0000579_abnormal_nail_morphology0.29570272

Predicted human phenotypes

RankGene SetZ-score
1Hypobetalipoproteinemia (HP:0003563)7.99976412
2Abnormality of glutamine family amino acid metabolism (HP:0010902)7.09125380
3Ileus (HP:0002595)6.43541827
4Acanthocytosis (HP:0001927)5.96458608
5Conjugated hyperbilirubinemia (HP:0002908)5.52985879
6Intrahepatic cholestasis (HP:0001406)5.39267425
7Hypolipoproteinemia (HP:0010981)5.26422110
8Abnormality of monocarboxylic acid metabolism (HP:0010996)5.24476032
9Xanthomatosis (HP:0000991)5.17620718
10Malnutrition (HP:0004395)5.06911600
11Fat malabsorption (HP:0002630)5.04019525
12Hydroxyprolinuria (HP:0003080)4.83373904
13Abnormality of proline metabolism (HP:0010907)4.83373904
14Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.41288415
15Hyperglycinuria (HP:0003108)4.38780120
16Autoimmune thrombocytopenia (HP:0001973)4.10434255
17Right ventricular cardiomyopathy (HP:0011663)3.96214779
18Abnormality of aspartate family amino acid metabolism (HP:0010899)3.86424524
19Abnormality of aromatic amino acid family metabolism (HP:0004338)3.76381591
20Epidermoid cyst (HP:0200040)3.75236690
21Systemic lupus erythematosus (HP:0002725)3.73732157
22Abnormality of sulfur amino acid metabolism (HP:0004339)3.70512590
23Poikilocytosis (HP:0004447)3.67620815
24Deep venous thrombosis (HP:0002625)3.66712769
25Abnormality of serine family amino acid metabolism (HP:0010894)3.57979967
26Abnormality of glycine metabolism (HP:0010895)3.57979967
27Hyperammonemia (HP:0001987)3.53945496
28Hypercholesterolemia (HP:0003124)3.53348454
29Decreased circulating renin level (HP:0003351)3.51269301
30Thin bony cortex (HP:0002753)3.42587320
31Pigmentary retinal degeneration (HP:0001146)3.40443267
32Congenital sensorineural hearing impairment (HP:0008527)3.30791651
33Hyperactive renin-angiotensin system (HP:0000841)3.26807756
34Metabolic alkalosis (HP:0200114)3.22585056
35Cupped ribs (HP:0000887)3.20492867
36Alkalosis (HP:0001948)3.20048326
37Hypoalphalipoproteinemia (HP:0003233)3.17322935
38Prolonged partial thromboplastin time (HP:0003645)3.12424991
39Widely patent fontanelles and sutures (HP:0004492)3.09115132
40Chronic diarrhea (HP:0002028)3.07403616
41Hypoglycemic coma (HP:0001325)3.02232740
42Posterior subcapsular cataract (HP:0007787)2.97800350
43Abnormality of urine glucose concentration (HP:0011016)2.95481347
44Glycosuria (HP:0003076)2.95481347
45Abdominal distention (HP:0003270)2.93512507
46Increased purine levels (HP:0004368)2.92043425
47Hyperuricemia (HP:0002149)2.92043425
48Hyperbilirubinemia (HP:0002904)2.88326229
49Enlarged epiphyses (HP:0010580)2.87001859
50Autoimmune hemolytic anemia (HP:0001890)2.84509261
51Metabolic acidosis (HP:0001942)2.84070769
52Abnormality of purine metabolism (HP:0004352)2.82486749
53Hypophosphatemia (HP:0002148)2.81103930
54Potter facies (HP:0002009)2.79432999
55Facial shape deformation (HP:0011334)2.79432999
56Abnormality of renin-angiotensin system (HP:0000847)2.73491260
57Abnormality of nucleobase metabolism (HP:0010932)2.71593952
58Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.70020736
59Hyperlipoproteinemia (HP:0010980)2.68932440
60Villous atrophy (HP:0011473)2.63809362
61Abnormality of small intestinal villus morphology (HP:0011472)2.63809362
62Abnormal urine phosphate concentration (HP:0012599)2.60626164
63Eczematoid dermatitis (HP:0000976)2.57600868
64Abnormality of vitamin metabolism (HP:0100508)2.55596779
65Abnormality of the common coagulation pathway (HP:0010990)2.53095481
66Ketosis (HP:0001946)2.52245197
67Reticulocytosis (HP:0001923)2.51742537
68Abnormality of pyrimidine metabolism (HP:0004353)2.49808358
69Nephrolithiasis (HP:0000787)2.49559918
70Gastrointestinal dysmotility (HP:0002579)2.47859513
71Cholecystitis (HP:0001082)2.47334661
72Abnormal gallbladder physiology (HP:0012438)2.47334661
73Increased mean platelet volume (HP:0011877)2.47096398
74Abnormality of fatty-acid metabolism (HP:0004359)2.44681936
75Mesangial abnormality (HP:0001966)2.43731278
76Delayed epiphyseal ossification (HP:0002663)2.43644987
77Hyperparathyroidism (HP:0000843)2.42255913
78Abnormality of the costochondral junction (HP:0000919)2.37926974
79Ketoacidosis (HP:0001993)2.37203270
80Steatorrhea (HP:0002570)2.35466891
81Abnormality of the vitamin B12 metabolism (HP:0004341)2.35087823
82Focal segmental glomerulosclerosis (HP:0000097)2.32716144
83Abnormality of vitamin B metabolism (HP:0004340)2.28395097
84Complement deficiency (HP:0004431)2.28361698
85Pancreatitis (HP:0001733)2.26195945
86Hypotension (HP:0002615)2.25481225
87Confusion (HP:0001289)2.24866314
88Cerebral palsy (HP:0100021)2.22868160
89Amyloidosis (HP:0011034)2.21204230
90Dehydration (HP:0001944)2.19199484
91Skin nodule (HP:0200036)2.18138135
92Abnormal platelet volume (HP:0011876)2.14192657
93Late onset (HP:0003584)2.12876916
94Hyperglycinemia (HP:0002154)2.12227930
95Polycythemia (HP:0001901)2.10711058
96Increased IgE level (HP:0003212)2.09655045
97Abnormality of magnesium homeostasis (HP:0004921)2.09100663
98Hyperphosphaturia (HP:0003109)2.08932609
99Symptomatic seizures (HP:0011145)2.08537424
100Abnormal glucose tolerance (HP:0001952)2.07884656
101Subcapsular cataract (HP:0000523)2.04426669
102Nausea (HP:0002018)2.02800600
103Protuberant abdomen (HP:0001538)2.01835300
104Cholelithiasis (HP:0001081)2.01275884
105Abnormality of the intrinsic pathway (HP:0010989)1.99572745
106Abnormal gallbladder morphology (HP:0012437)1.99319504
107Gout (HP:0001997)1.98354347
108Dicarboxylic aciduria (HP:0003215)1.97694239
109Abnormality of dicarboxylic acid metabolism (HP:0010995)1.97694239
110Hemorrhage of the eye (HP:0011885)1.97171129
111Vascular calcification (HP:0004934)1.97050694
112Sensorimotor neuropathy (HP:0007141)1.95928368
113Irritability (HP:0000737)1.95229745
114Renal tubular acidosis (HP:0001947)1.95160639
115Hypoglycemic seizures (HP:0002173)1.94933680
116Palpitations (HP:0001962)1.94904194
117Hyperphosphatemia (HP:0002905)1.93576406
118Gingivitis (HP:0000230)1.91613979
119Esophageal varix (HP:0002040)1.87298424
120Abnormal albumin level (HP:0012116)1.86475910
121Hypoalbuminemia (HP:0003073)1.86475910
122Abnormal cartilage morphology (HP:0002763)1.86327396
123Lethargy (HP:0001254)1.83485165
124Flat acetabular roof (HP:0003180)1.83108046
125Pustule (HP:0200039)1.82550370
126Proximal tubulopathy (HP:0000114)1.82480192
127Megaloblastic anemia (HP:0001889)1.81848796
128Abnormal biliary tract morphology (HP:0012440)1.81703985
129Renal tubular dysfunction (HP:0000124)1.81484818
130Goiter (HP:0000853)1.80181525
131Wide cranial sutures (HP:0010537)1.80031223
132Glomerulonephritis (HP:0000099)1.79991095
133Abnormality of methionine metabolism (HP:0010901)1.79303797
134Severe combined immunodeficiency (HP:0004430)1.77738763
135Joint hemorrhage (HP:0005261)1.77686910
136Combined immunodeficiency (HP:0005387)1.77465993
137Glomerulosclerosis (HP:0000096)1.74425831
138Nephritis (HP:0000123)1.71306479
139Metaphyseal irregularity (HP:0003025)1.70000188
140Hypocalcemia (HP:0002901)1.69146159
141Growth hormone excess (HP:0000845)1.68227024
142Hypokalemia (HP:0002900)1.67868784
143Chorioretinal atrophy (HP:0000533)1.67675985
144Multiple lipomas (HP:0001012)1.67291293
145Paresthesia (HP:0003401)1.67008900
146Hyperaldosteronism (HP:0000859)1.65805703

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B9.37655281
2FRK6.53887408
3MST1R4.91876306
4MST44.55788235
5LMTK24.32856187
6GRK63.48230566
7PRKG23.03565588
8ERN12.80187332
9STK392.54931154
10NME12.53793563
11EPHA22.46275446
12RIPK12.46084304
13MAP3K102.37585567
14MAP2K22.32116202
15PTK62.28584556
16AKT32.19399439
17OXSR12.18135303
18MAP3K22.09547065
19NUAK11.94370334
20MAP3K121.78888808
21MET1.76034668
22EPHA31.66507208
23TNIK1.57331469
24EPHB21.54999071
25TAOK31.51521269
26PIK3CA1.41552297
27BCKDK1.32344386
28MYLK1.28500390
29EPHA41.24788597
30TESK11.24611009
31FGFR41.23481862
32MAP3K71.14954865
33TESK21.14943934
34STK241.14605545
35LATS11.12903381
36MAP2K61.07585271
37PRKAA21.05571497
38KSR21.04400917
39MAPK111.02222942
40ERBB21.01288720
41STK101.00876264
42NLK0.97997265
43ERBB40.97016979
44MAP3K110.96978763
45EPHB10.96168116
46SIK10.96065781
47TAOK10.94567817
48PTK20.93886534
49PIM10.91643646
50CASK0.90876936
51FGFR30.90325405
52DDR20.88361863
53MAP2K10.87370694
54BMPR20.86436601
55TBK10.85841348
56IRAK10.83969324
57BMX0.80846779
58PBK0.80523268
59INSRR0.78828927
60MATK0.78429529
61MAP3K80.77780886
62FER0.73433726
63PKN20.72817950
64TYK20.70892397
65PRKCI0.69799460
66MAP3K10.68691999
67MAP3K30.67904425
68TEC0.66865573
69CDC42BPA0.58565382
70PDPK10.57337661
71JAK10.55791412
72PRKAA10.55674115
73CSK0.54625183
74ADRBK20.54157063
75TTK0.53809600
76ICK0.50180381
77PAK40.47974280
78GRK10.47764581
79SYK0.47487570
80DYRK1B0.47463305
81MAP2K40.46699628
82CDK60.46419941
83IKBKE0.46256262
84DAPK20.44432183
85BTK0.44170837
86PRKACG0.43118854
87CAMK2G0.43084238
88PRPF4B0.43004368
89PIK3CG0.42018088
90YES10.41584874
91RIPK40.40875777
92CDK190.40662530
93PAK30.39236848
94CSF1R0.37960054
95PRKCA0.37359082
96JAK20.37202449
97PDK10.36343246
98KIT0.35186634
99IRAK30.35154152
100MAPK40.35032237
101PRKCQ0.34733066
102PDK20.33194486
103JAK30.32839423
104RET0.31960850
105LYN0.31290407
106LRRK20.30792746
107GSK3A0.30617463
108PRKCZ0.29711369
109CAMK2D0.29464764
110ERBB30.25979736
111PRKACA0.25850397
112SRC0.25720446
113IGF1R0.25639696
114CAMK2B0.25450217
115MELK0.25036432
116IRAK40.24958390
117LCK0.24571448
118ABL20.24123668
119ITK0.24071729
120NEK60.23929148
121TXK0.23708101
122PAK20.23141308
123STK30.22735793
124CAMK2A0.22230235
125KDR0.22193725
126DMPK0.21924405
127PRKCD0.21449583
128LIMK10.20086905
129SCYL20.20063650
130CSNK1A10.18674922
131MAP3K90.18623518
132MAP4K10.18344431
133PDGFRA0.18168075
134AKT20.18127530
135MAP3K140.17162828
136ROCK10.17028479
137FLT30.16773833
138FYN0.16011820
139MAPKAPK20.15428137
140TRIB30.14899336

Predicted pathways (KEGG)

RankGene SetZ-score
1* Fat digestion and absorption_Homo sapiens_hsa049754.36134558
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.57199068
3Vitamin digestion and absorption_Homo sapiens_hsa049773.29076847
4Renin-angiotensin system_Homo sapiens_hsa046143.18104752
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.95691243
6Caffeine metabolism_Homo sapiens_hsa002322.64451336
7Mineral absorption_Homo sapiens_hsa049782.56814881
8Sulfur metabolism_Homo sapiens_hsa009202.45273738
9Nitrogen metabolism_Homo sapiens_hsa009102.36289083
10Starch and sucrose metabolism_Homo sapiens_hsa005002.35162718
11Arginine biosynthesis_Homo sapiens_hsa002202.32882834
12Bile secretion_Homo sapiens_hsa049762.29609316
13Primary bile acid biosynthesis_Homo sapiens_hsa001202.29603079
14Histidine metabolism_Homo sapiens_hsa003402.27374300
15Tryptophan metabolism_Homo sapiens_hsa003802.24938579
16Fatty acid degradation_Homo sapiens_hsa000712.06731828
17Galactose metabolism_Homo sapiens_hsa000521.98107647
18Folate biosynthesis_Homo sapiens_hsa007901.97895241
19Pentose and glucuronate interconversions_Homo sapiens_hsa000401.92233609
20Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.85514422
21Maturity onset diabetes of the young_Homo sapiens_hsa049501.79027250
22* PPAR signaling pathway_Homo sapiens_hsa033201.75968987
23Carbohydrate digestion and absorption_Homo sapiens_hsa049731.64982106
24Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.63063077
25Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.57688341
26Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.56891113
27Protein digestion and absorption_Homo sapiens_hsa049741.49391780
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.45347673
29Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.44911856
30Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.41964262
31Butanoate metabolism_Homo sapiens_hsa006501.39725398
32Cyanoamino acid metabolism_Homo sapiens_hsa004601.37172896
332-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.36797549
34Chemical carcinogenesis_Homo sapiens_hsa052041.36453907
35Fructose and mannose metabolism_Homo sapiens_hsa000511.36346427
36Drug metabolism - other enzymes_Homo sapiens_hsa009831.32397953
37Asthma_Homo sapiens_hsa053101.32041959
38Glycerolipid metabolism_Homo sapiens_hsa005611.31656142
39Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.31497130
40Peroxisome_Homo sapiens_hsa041461.29745809
41beta-Alanine metabolism_Homo sapiens_hsa004101.26448936
42Fatty acid metabolism_Homo sapiens_hsa012121.23744096
43Retinol metabolism_Homo sapiens_hsa008301.23645579
44Glutathione metabolism_Homo sapiens_hsa004801.22019193
45Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.18781417
46ABC transporters_Homo sapiens_hsa020101.18433476
47Steroid hormone biosynthesis_Homo sapiens_hsa001401.17890480
48Pyruvate metabolism_Homo sapiens_hsa006201.17224630
49Arginine and proline metabolism_Homo sapiens_hsa003301.15864054
50Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.05712339
51Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.02767295
52Carbon metabolism_Homo sapiens_hsa012001.00816174
53Propanoate metabolism_Homo sapiens_hsa006400.99816258
54Complement and coagulation cascades_Homo sapiens_hsa046100.99128099
55Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.95040700
56Allograft rejection_Homo sapiens_hsa053300.91917022
57Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.91157774
58Phenylalanine metabolism_Homo sapiens_hsa003600.88178151
59Autoimmune thyroid disease_Homo sapiens_hsa053200.84920617
60Selenocompound metabolism_Homo sapiens_hsa004500.83977482
61Graft-versus-host disease_Homo sapiens_hsa053320.83237200
62Biosynthesis of amino acids_Homo sapiens_hsa012300.76577286
63Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.74816587
64Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.74388513
65Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.70126323
66Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.69758535
67Steroid biosynthesis_Homo sapiens_hsa001000.69587809
68Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.69444121
69Pentose phosphate pathway_Homo sapiens_hsa000300.69317518
70alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.69281675
71Tyrosine metabolism_Homo sapiens_hsa003500.66169386
72Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.65134495
73Fatty acid elongation_Homo sapiens_hsa000620.64284731
74Type I diabetes mellitus_Homo sapiens_hsa049400.63348013
75Fatty acid biosynthesis_Homo sapiens_hsa000610.59199456
76Sphingolipid metabolism_Homo sapiens_hsa006000.58604139
77Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.57872138
78Glycerophospholipid metabolism_Homo sapiens_hsa005640.57597964
79Linoleic acid metabolism_Homo sapiens_hsa005910.51197455
80Lysine degradation_Homo sapiens_hsa003100.50305331
81Cysteine and methionine metabolism_Homo sapiens_hsa002700.46637253
82Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.44811165
83Staphylococcus aureus infection_Homo sapiens_hsa051500.43075605
84Thyroid hormone synthesis_Homo sapiens_hsa049180.43046603
85Metabolic pathways_Homo sapiens_hsa011000.41562531
86Renin secretion_Homo sapiens_hsa049240.39085298
87Antigen processing and presentation_Homo sapiens_hsa046120.38665920
88Sulfur relay system_Homo sapiens_hsa041220.37478027
89Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.27697542
90Leishmaniasis_Homo sapiens_hsa051400.26899629
91Arachidonic acid metabolism_Homo sapiens_hsa005900.24421022
92Cocaine addiction_Homo sapiens_hsa050300.18178782
93Other glycan degradation_Homo sapiens_hsa005110.16788252
94Type II diabetes mellitus_Homo sapiens_hsa049300.15427139
95African trypanosomiasis_Homo sapiens_hsa051430.15384721
96Serotonergic synapse_Homo sapiens_hsa047260.15132274
97Hematopoietic cell lineage_Homo sapiens_hsa046400.14133648
98Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.14070182
99Insulin resistance_Homo sapiens_hsa049310.13874580
100Tight junction_Homo sapiens_hsa045300.13391535
101Viral myocarditis_Homo sapiens_hsa054160.12912410
102Insulin secretion_Homo sapiens_hsa049110.10290613
103Glucagon signaling pathway_Homo sapiens_hsa049220.09006158
104Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.08875922
105Pancreatic secretion_Homo sapiens_hsa049720.08669847
106Ether lipid metabolism_Homo sapiens_hsa005650.07939421
107Pertussis_Homo sapiens_hsa051330.06940883
108Hepatitis C_Homo sapiens_hsa051600.05617731
109Amphetamine addiction_Homo sapiens_hsa050310.05570301
110Toxoplasmosis_Homo sapiens_hsa051450.04881004
111Bladder cancer_Homo sapiens_hsa052190.04041458
112Ovarian steroidogenesis_Homo sapiens_hsa049130.03255722
113Adipocytokine signaling pathway_Homo sapiens_hsa049200.01908701
114Gastric acid secretion_Homo sapiens_hsa04971-0.1272514
115Salmonella infection_Homo sapiens_hsa05132-0.1104214
116AMPK signaling pathway_Homo sapiens_hsa04152-0.0971642
117Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961-0.0948352
118Leukocyte transendothelial migration_Homo sapiens_hsa04670-0.0891444
119Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960-0.0627669
120Thyroid cancer_Homo sapiens_hsa05216-0.0467800
121Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.0366792
122Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0103181
123Chemokine signaling pathway_Homo sapiens_hsa04062-0.0085993
124Tuberculosis_Homo sapiens_hsa05152-0.0032980
125Intestinal immune network for IgA production_Homo sapiens_hsa04672-0.0009910

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