FABP5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the fatty acid binding protein found in epidermal cells, and was first identified as being upregulated in psoriasis tissue. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. FABPs may play roles in fatty acid uptake, transport, and metabolism. Polymorphisms in this gene are associated with type 2 diabetes. The human genome contains many pseudogenes similar to this locus. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)7.87030276
2central nervous system myelination (GO:0022010)7.87030276
3fatty acid elongation (GO:0030497)7.01745632
4establishment of protein localization to mitochondrial membrane (GO:0090151)6.47808748
5long-chain fatty acid biosynthetic process (GO:0042759)5.93457830
6neutrophil activation involved in immune response (GO:0002283)5.08555997
7proteasome assembly (GO:0043248)5.02864296
8cholesterol biosynthetic process (GO:0006695)4.89058370
9chromatin remodeling at centromere (GO:0031055)4.39743625
10CENP-A containing nucleosome assembly (GO:0034080)4.35965740
11sterol biosynthetic process (GO:0016126)4.34769282
12ATP synthesis coupled proton transport (GO:0015986)4.21664498
13energy coupled proton transport, down electrochemical gradient (GO:0015985)4.21664498
14mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.20946413
15protein neddylation (GO:0045116)4.19076113
16DNA double-strand break processing (GO:0000729)4.18183223
17molting cycle (GO:0042303)4.12518653
18hair cycle (GO:0042633)4.12518653
19response to lipoprotein particle (GO:0055094)4.09470381
20myelination (GO:0042552)4.00665491
21ensheathment of neurons (GO:0007272)3.99906641
22axon ensheathment (GO:0008366)3.99906641
23isoprenoid biosynthetic process (GO:0008299)3.99399917
24keratinization (GO:0031424)3.95954513
25amyloid precursor protein metabolic process (GO:0042982)3.85987582
26long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.85926941
27amyloid precursor protein catabolic process (GO:0042987)3.83896116
28positive regulation of oligodendrocyte differentiation (GO:0048714)3.80037959
29transcription elongation from RNA polymerase III promoter (GO:0006385)3.68312666
30termination of RNA polymerase III transcription (GO:0006386)3.68312666
31negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.67462617
32positive regulation of monocyte chemotaxis (GO:0090026)3.63371260
33long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.63222093
34histone exchange (GO:0043486)3.61141569
35respiratory chain complex IV assembly (GO:0008535)3.58762336
36establishment of integrated proviral latency (GO:0075713)3.58445361
37mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.56320723
38mitotic metaphase plate congression (GO:0007080)3.55828853
39nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.44747795
40DNA damage response, detection of DNA damage (GO:0042769)3.43995530
41regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.43221435
42exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.42005412
43adhesion of symbiont to host cell (GO:0044650)3.41437323
44virion attachment to host cell (GO:0019062)3.41437323
45DNA replication checkpoint (GO:0000076)3.38831974
46mitochondrial respiratory chain complex assembly (GO:0033108)3.38740287
47negative regulation of ligase activity (GO:0051352)3.38733464
48negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.38733464
49mitochondrial respiratory chain complex I assembly (GO:0032981)3.37579047
50NADH dehydrogenase complex assembly (GO:0010257)3.37579047
51mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.37579047
52substantia nigra development (GO:0021762)3.37572636
53positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.33790694
54protein complex biogenesis (GO:0070271)3.32922931
55ribosomal large subunit biogenesis (GO:0042273)3.25182881
56fatty-acyl-CoA biosynthetic process (GO:0046949)3.24246565
57anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.22794884
58cullin deneddylation (GO:0010388)3.22678710
59protein-cofactor linkage (GO:0018065)3.20427252
60DNA replication-independent nucleosome assembly (GO:0006336)3.19870010
61DNA replication-independent nucleosome organization (GO:0034724)3.19870010
62spliceosomal snRNP assembly (GO:0000387)3.19836141
63histone mRNA metabolic process (GO:0008334)3.16882883
64water-soluble vitamin biosynthetic process (GO:0042364)3.16815095
65maturation of 5.8S rRNA (GO:0000460)3.15042008
66protein localization to mitochondrion (GO:0070585)3.13902967
67rRNA modification (GO:0000154)3.13843636
68granulocyte activation (GO:0036230)3.12882529
69purine nucleobase biosynthetic process (GO:0009113)3.12510523
70regulation of collateral sprouting (GO:0048670)3.12263041
71fatty-acyl-CoA metabolic process (GO:0035337)3.11246642
72intracellular protein transmembrane import (GO:0044743)3.11076963
73neuron fate determination (GO:0048664)3.10092155
74protein targeting to mitochondrion (GO:0006626)3.09605389
75protein localization to kinetochore (GO:0034501)3.07566418
76chaperone-mediated protein transport (GO:0072321)3.07528453
77establishment of protein localization to mitochondrion (GO:0072655)3.07224863
78neutrophil activation (GO:0042119)3.06468198
79pseudouridine synthesis (GO:0001522)3.06337311
80negative regulation of DNA-dependent DNA replication (GO:2000104)3.04982984
81respiratory burst (GO:0045730)3.04229715
82regulation of mesoderm development (GO:2000380)3.03289839
83cytochrome complex assembly (GO:0017004)3.03119652
84inner mitochondrial membrane organization (GO:0007007)3.03088009
85respiratory electron transport chain (GO:0022904)3.02240294
86phagosome maturation (GO:0090382)3.01066847
87DNA catabolic process, exonucleolytic (GO:0000738)3.00894600
88L-amino acid import (GO:0043092)2.98300940
89positive regulation of actin filament depolymerization (GO:0030836)2.95762096
90metaphase plate congression (GO:0051310)2.94999574
91limb bud formation (GO:0060174)2.94580747
92IMP biosynthetic process (GO:0006188)2.93872510
93electron transport chain (GO:0022900)2.92769972
94protein deneddylation (GO:0000338)2.92071002
95oxidative phosphorylation (GO:0006119)2.91397585
96regulation of mitotic spindle checkpoint (GO:1903504)2.90051482
97regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.90051482
98ribosome assembly (GO:0042255)2.87226529
99regulation of cellular amino acid metabolic process (GO:0006521)2.86884601
100nucleobase biosynthetic process (GO:0046112)2.86727242
101positive regulation of pseudopodium assembly (GO:0031274)2.86524165
102kinetochore organization (GO:0051383)2.82833847
103regulation of mitochondrial translation (GO:0070129)2.82806139
104positive regulation by symbiont of host defense response (GO:0052509)2.81204640
105modulation by symbiont of host defense response (GO:0052031)2.81204640
106modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.81204640
107modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.81204640
108positive regulation by organism of defense response of other organism involved in symbiotic interact2.81204640
109modulation by symbiont of host immune response (GO:0052553)2.81204640
110positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.80950338
111positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.76222322
112DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.75935134
113rRNA processing (GO:0006364)2.75817252
114negative regulation of protein localization to cell surface (GO:2000009)2.74827745
115response to methylmercury (GO:0051597)2.74278985
116oligodendrocyte differentiation (GO:0048709)2.74263501
117kinetochore assembly (GO:0051382)2.73844684
118ribosomal small subunit assembly (GO:0000028)2.72271885
119superoxide anion generation (GO:0042554)2.72073531
120signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.71342009
121signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.71342009
122signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.71342009
123protein refolding (GO:0042026)2.70934817
124positive regulation of ligase activity (GO:0051351)2.69907675
125signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.67876257
126intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.67876257
127primitive streak formation (GO:0090009)2.67131476
128regulation of helicase activity (GO:0051095)2.66688713
129translation (GO:0006412)2.65891792
130rRNA metabolic process (GO:0016072)2.65083767
1317-methylguanosine mRNA capping (GO:0006370)2.64912741
132myelin maintenance (GO:0043217)2.64305425
133establishment of viral latency (GO:0019043)2.62654548
134somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.60031587
135somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.60031587
136isotype switching (GO:0045190)2.60031587
137regulation of ubiquitin-protein transferase activity (GO:0051438)2.59724878
138maturation of SSU-rRNA (GO:0030490)2.59672148
139rRNA methylation (GO:0031167)2.59670706
140pteridine-containing compound biosynthetic process (GO:0042559)2.59141140
141adhesion of symbiont to host (GO:0044406)2.58916351
142transcription from mitochondrial promoter (GO:0006390)2.58647087
143DNA ligation (GO:0006266)2.58584727
144regulation of monocyte chemotaxis (GO:0090025)2.56067913
145antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.53003715
146aldehyde catabolic process (GO:0046185)2.50931362
147regulation of activation of Janus kinase activity (GO:0010533)2.50747270
148very long-chain fatty acid metabolic process (GO:0000038)2.50205142
149regulation of pseudopodium assembly (GO:0031272)2.49989852
150lateral sprouting from an epithelium (GO:0060601)2.49452670
151regulation of heat generation (GO:0031650)2.48952804
152regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.48381160
153positive regulation of interleukin-17 production (GO:0032740)2.47394262
154positive regulation of glial cell differentiation (GO:0045687)2.46370718
155tissue regeneration (GO:0042246)2.45249104
156eosinophil chemotaxis (GO:0048245)2.44789806
157positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.43330047
158regulation of dendritic cell antigen processing and presentation (GO:0002604)2.41600032
159intermediate filament organization (GO:0045109)2.41485732
160amino acid import (GO:0043090)2.41463029
161import into cell (GO:0098657)2.40408842
162regulation of interleukin-17 production (GO:0032660)2.39149933
163leukocyte migration involved in inflammatory response (GO:0002523)2.36165234
164energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.35753938
165ATP hydrolysis coupled proton transport (GO:0015991)2.35753938
166cellular copper ion homeostasis (GO:0006878)2.35069852
167neural nucleus development (GO:0048857)2.34707197
168acyl-CoA biosynthetic process (GO:0071616)2.34050037
169thioester biosynthetic process (GO:0035384)2.34050037
170monocyte chemotaxis (GO:0002548)2.33585732
171microglial cell activation (GO:0001774)2.33578968
172negative regulation of neurotransmitter transport (GO:0051589)2.31922308
173negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.31729031
174myeloid cell activation involved in immune response (GO:0002275)2.31447412
175macrophage activation involved in immune response (GO:0002281)2.31189000
176regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.30220098
177regulation of fever generation (GO:0031620)2.29691860
178detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.29315405
179detection of temperature stimulus involved in sensory perception (GO:0050961)2.29315405
180axon development (GO:0061564)2.27965127
181enteric nervous system development (GO:0048484)2.27764765
182sphingoid metabolic process (GO:0046519)2.27608719
183regulation of oligodendrocyte differentiation (GO:0048713)2.27598261
184positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.26989283
185regulation of mononuclear cell migration (GO:0071675)2.26816943
186creatine metabolic process (GO:0006600)2.25227914
187positive regulation of antigen processing and presentation (GO:0002579)2.24406583

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.08455708
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.49831423
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.47384730
4GABP_17652178_ChIP-ChIP_JURKAT_Human4.31014434
5TP63_17297297_ChIP-ChIP_HaCaT_Human4.16251125
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.81770434
7IRF8_21731497_ChIP-ChIP_J774_Mouse3.62518512
8MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.19200391
9CREB1_15753290_ChIP-ChIP_HEK293T_Human3.03401887
10MYC_18555785_ChIP-Seq_MESCs_Mouse3.02498278
11E2F7_22180533_ChIP-Seq_HELA_Human2.99403387
12CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.91473318
13E2F4_17652178_ChIP-ChIP_JURKAT_Human2.80678449
14HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.78376344
15ELK1_19687146_ChIP-ChIP_HELA_Human2.61634358
16CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.57638750
17JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.51937332
18ETS1_20019798_ChIP-Seq_JURKAT_Human2.46472270
19NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.28513155
20TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.22263717
21* CDX2_19796622_ChIP-Seq_MESCs_Mouse2.15812011
22ZNF274_21170338_ChIP-Seq_K562_Hela2.02973660
23EZH2_27304074_Chip-Seq_ESCs_Mouse2.01089952
24SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.00910702
25VDR_23849224_ChIP-Seq_CD4+_Human2.00893333
26* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.00587206
27HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.00099667
28JARID2_20064375_ChIP-Seq_MESCs_Mouse1.99932429
29EWS_26573619_Chip-Seq_HEK293_Human1.99353320
30SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.95725462
31Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.95293971
32SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.95239202
33TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.94562126
34SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.90957203
35MYC_19079543_ChIP-ChIP_MESCs_Mouse1.89384888
36AR_21572438_ChIP-Seq_LNCaP_Human1.86613901
37CBX2_27304074_Chip-Seq_ESCs_Mouse1.85593029
38SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.85541369
39AR_21909140_ChIP-Seq_LNCAP_Human1.84705092
40FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.82692596
41PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.78455117
42* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.78139568
43JARID2_20075857_ChIP-Seq_MESCs_Mouse1.77149569
44ZFP57_27257070_Chip-Seq_ESCs_Mouse1.77110535
45EED_16625203_ChIP-ChIP_MESCs_Mouse1.76093082
46SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.76072331
47E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.75576587
48FUS_26573619_Chip-Seq_HEK293_Human1.74167735
49TRIM28_21343339_ChIP-Seq_HEK293_Human1.74040898
50CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.73568831
51PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.72744901
52FLI1_27457419_Chip-Seq_LIVER_Mouse1.72290652
53* IRF8_27001747_Chip-Seq_BMDM_Mouse1.70662805
54* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.70384364
55FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.69933862
56IRF8_22096565_ChIP-ChIP_GC-B_Human1.69050813
57RNF2_18974828_ChIP-Seq_MESCs_Mouse1.69024161
58EZH2_18974828_ChIP-Seq_MESCs_Mouse1.69024161
59VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.69003518
60DCP1A_22483619_ChIP-Seq_HELA_Human1.67777444
61NOTCH1_21737748_ChIP-Seq_TLL_Human1.67355113
62E2F1_18555785_ChIP-Seq_MESCs_Mouse1.67309212
63ER_23166858_ChIP-Seq_MCF-7_Human1.66981081
64FOXP3_21729870_ChIP-Seq_TREG_Human1.62154687
65MTF2_20144788_ChIP-Seq_MESCs_Mouse1.59315503
66NELFA_20434984_ChIP-Seq_ESCs_Mouse1.58717780
67VDR_22108803_ChIP-Seq_LS180_Human1.57630290
68POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.56625945
69SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.56377311
70TTF2_22483619_ChIP-Seq_HELA_Human1.56109855
71PADI4_21655091_ChIP-ChIP_MCF-7_Human1.54096408
72SRF_21415370_ChIP-Seq_HL-1_Mouse1.51992672
73NRF2_20460467_ChIP-Seq_MEFs_Mouse1.51741808
74NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.51741808
75BMI1_23680149_ChIP-Seq_NPCS_Mouse1.51529654
76MYC_18940864_ChIP-ChIP_HL60_Human1.49785656
77VDR_24787735_ChIP-Seq_THP-1_Human1.49456798
78PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.48796952
79EZH2_27294783_Chip-Seq_ESCs_Mouse1.47537315
80RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.45766654
81RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.42201791
82HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.41359123
83OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.40363572
84PCGF2_27294783_Chip-Seq_ESCs_Mouse1.39839347
85RNF2_27304074_Chip-Seq_ESCs_Mouse1.39588588
86NANOG_16153702_ChIP-ChIP_HESCs_Human1.39101867
87TAF15_26573619_Chip-Seq_HEK293_Human1.34791607
88GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34615871
89SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.32559095
90ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.32086784
91P63_26484246_Chip-Seq_KERATINOCYTES_Human1.30250417
92EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.29000643
93SALL1_21062744_ChIP-ChIP_HESCs_Human1.28360126
94RBPJ_22232070_ChIP-Seq_NCS_Mouse1.27041127
95PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.26733034
96GBX2_23144817_ChIP-Seq_PC3_Human1.23795871
97EGR1_19032775_ChIP-ChIP_M12_Human1.23596829
98ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.23382778
99GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.22833780
100P300_19829295_ChIP-Seq_ESCs_Human1.22615285
101THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.22308844
102THAP11_20581084_ChIP-Seq_MESCs_Mouse1.21457303
103SOX2_16153702_ChIP-ChIP_HESCs_Human1.20181593
104NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.19899030
105MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.19511185
106CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.18985324
107GABP_19822575_ChIP-Seq_HepG2_Human1.18410426
108YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.17994267
109XRN2_22483619_ChIP-Seq_HELA_Human1.16611521
110IGF1R_20145208_ChIP-Seq_DFB_Human1.15572234
111NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.14159524
112ELK1_22589737_ChIP-Seq_MCF10A_Human1.13347416
113* TP53_18474530_ChIP-ChIP_U2OS_Human1.12240448
114ELF1_17652178_ChIP-ChIP_JURKAT_Human1.11757306
115* SOX2_20726797_ChIP-Seq_SW620_Human1.11073747
116MYCN_18555785_ChIP-Seq_MESCs_Mouse1.10674201
117WT1_19549856_ChIP-ChIP_CCG9911_Human1.10261781
118KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.09958330
119IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.09764695
120NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.08643370
121EZH2_22144423_ChIP-Seq_EOC_Human1.08453661
122SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.07688734
123SOX2_18555785_ChIP-Seq_MESCs_Mouse1.07665836
124HOXB4_20404135_ChIP-ChIP_EML_Mouse1.06913182
125TCF3_18692474_ChIP-Seq_MEFs_Mouse1.06623024
126PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.03794942
127SMAD3_21741376_ChIP-Seq_EPCs_Human1.02606149
128TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01987295
129* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01498724
130POU5F1_16153702_ChIP-ChIP_HESCs_Human1.00808435
131CTBP2_25329375_ChIP-Seq_LNCAP_Human0.99537905
132MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.99329022
133NANOG_18555785_ChIP-Seq_MESCs_Mouse0.99264031
134NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.99169053
135KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.98122469
136KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.98122469
137KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.98122469
138HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.97910018
139PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.94582773
140PCGF2_27294783_Chip-Seq_NPCs_Mouse0.93756148
141* E2F1_21310950_ChIP-Seq_MCF-7_Human0.93089056
142CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.92645022
143CTBP1_25329375_ChIP-Seq_LNCAP_Human0.91655693
144CJUN_26792858_Chip-Seq_BT549_Human0.91479834
145TOP2B_26459242_ChIP-Seq_MCF-7_Human0.89435303
146POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.89263138
147STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.89010106
148EZH2_27294783_Chip-Seq_NPCs_Mouse0.88395026
149POU3F2_20337985_ChIP-ChIP_501MEL_Human0.87636112
150TCF4_22108803_ChIP-Seq_LS180_Human0.87038468
151GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.86581791
152TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.86316301
153SOX2_19829295_ChIP-Seq_ESCs_Human0.86113994
154NANOG_19829295_ChIP-Seq_ESCs_Human0.86113994
155FOXA1_27270436_Chip-Seq_PROSTATE_Human0.86074558
156SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.84874939
157* CMYC_18555785_Chip-Seq_ESCs_Mouse0.82976535
158NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.82729353
159PRDM14_20953172_ChIP-Seq_ESCs_Human0.82607730
160STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.82549189
161* PIAS1_25552417_ChIP-Seq_VCAP_Human0.82420068
162RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.81891657
163FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.81691729
164CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.81231082
165TP53_20018659_ChIP-ChIP_R1E_Mouse0.81071302
166PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.80597358
167STAT1_20625510_ChIP-Seq_HELA_Human0.79171750
168GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.79105141
169RNF2_27304074_Chip-Seq_NSC_Mouse0.78927822
170FOXO3_23340844_ChIP-Seq_DLD1_Human0.78273712
171CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.77801247
172HTT_18923047_ChIP-ChIP_STHdh_Human0.77799356
173TAL1_26923725_Chip-Seq_HPCs_Mouse0.76902966
174ERG_21242973_ChIP-ChIP_JURKAT_Human0.76383092
175NR3C1_23031785_ChIP-Seq_PC12_Mouse0.76196538
176ETV2_25802403_ChIP-Seq_MESCs_Mouse0.75565092
177* EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.74432952
178* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.72615031
179* FOXA1_21572438_ChIP-Seq_LNCaP_Human0.69230227

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000920_abnormal_myelination3.76128941
2MP0002254_reproductive_system_inflammat3.42019678
3MP0003890_abnormal_embryonic-extraembry3.34836776
4MP0008058_abnormal_DNA_repair2.99194249
5MP0003136_yellow_coat_color2.78581335
6MP0010094_abnormal_chromosome_stability2.70295863
7MP0003941_abnormal_skin_development2.68628213
8MP0001346_abnormal_lacrimal_gland2.64649932
9MP0000579_abnormal_nail_morphology2.63812270
10MP0006082_CNS_inflammation2.57467217
11MP0006072_abnormal_retinal_apoptosis2.55485027
12MP0004381_abnormal_hair_follicle2.52561525
13MP0003880_abnormal_central_pattern2.43326859
14MP0003690_abnormal_glial_cell2.40819186
15MP0004957_abnormal_blastocyst_morpholog2.38748731
16MP0003806_abnormal_nucleotide_metabolis2.32884676
17MP0001529_abnormal_vocalization2.25540458
18MP0000383_abnormal_hair_follicle2.25264148
19MP0000647_abnormal_sebaceous_gland2.22760577
20MP0002148_abnormal_hypersensitivity_rea2.17555210
21* MP0002796_impaired_skin_barrier2.16061566
22MP0005171_absent_coat_pigmentation2.15376546
23MP0006292_abnormal_olfactory_placode2.14580187
24MP0004742_abnormal_vestibular_system2.12667150
25MP0003693_abnormal_embryo_hatching2.07077800
26MP0001835_abnormal_antigen_presentation2.01226176
27MP0003950_abnormal_plasma_membrane2.01104396
28MP0005451_abnormal_body_composition2.00583459
29MP0008932_abnormal_embryonic_tissue1.97149841
30MP0003011_delayed_dark_adaptation1.93189120
31MP0001348_abnormal_lacrimal_gland1.91372207
32MP0010678_abnormal_skin_adnexa1.89631658
33MP0000778_abnormal_nervous_system1.88749140
34MP0003634_abnormal_glial_cell1.87231486
35MP0005058_abnormal_lysosome_morphology1.85843677
36MP0000604_amyloidosis1.84973613
37MP0001905_abnormal_dopamine_level1.80311451
38MP0005084_abnormal_gallbladder_morpholo1.80286145
39MP0010234_abnormal_vibrissa_follicle1.79831693
40MP0000372_irregular_coat_pigmentation1.77331748
41MP0009379_abnormal_foot_pigmentation1.73741490
42MP0002653_abnormal_ependyma_morphology1.67852184
43MP0005409_darkened_coat_color1.64336269
44MP0003077_abnormal_cell_cycle1.63824832
45MP0009785_altered_susceptibility_to1.63118194
46MP0008260_abnormal_autophagy1.63046333
47MP0003315_abnormal_perineum_morphology1.61252553
48MP0005275_abnormal_skin_tensile1.60215848
49MP0003436_decreased_susceptibility_to1.59914819
50MP0008789_abnormal_olfactory_epithelium1.59419774
51MP0005000_abnormal_immune_tolerance1.58683488
52MP0001293_anophthalmia1.54150326
53MP0002277_abnormal_respiratory_mucosa1.53468849
54MP0002419_abnormal_innate_immunity1.51100063
55MP0003718_maternal_effect1.47919088
56MP0002837_dystrophic_cardiac_calcinosis1.43686420
57MP0003878_abnormal_ear_physiology1.43681696
58MP0005377_hearing/vestibular/ear_phenot1.43681696
59MP0009053_abnormal_anal_canal1.43042381
60MP0001851_eye_inflammation1.41328965
61MP0004270_analgesia1.41125930
62MP0004133_heterotaxia1.39245806
63MP0003329_amyloid_beta_deposits1.38937279
64MP0004510_myositis1.38499452
65MP0002095_abnormal_skin_pigmentation1.36801887
66MP0003724_increased_susceptibility_to1.36316536
67MP0002295_abnormal_pulmonary_circulatio1.34388375
68MP0003937_abnormal_limbs/digits/tail_de1.34054292
69MP0003453_abnormal_keratinocyte_physiol1.33911124
70MP0005253_abnormal_eye_physiology1.33608790
71MP0004215_abnormal_myocardial_fiber1.31370108
72MP0000685_abnormal_immune_system1.31019701
73MP0005025_abnormal_response_to1.30808066
74MP0002090_abnormal_vision1.28741062
75MP0002736_abnormal_nociception_after1.27575001
76MP0002111_abnormal_tail_morphology1.27409969
77MP0002098_abnormal_vibrissa_morphology1.26496378
78MP0000566_synostosis1.26077664
79MP0000049_abnormal_middle_ear1.23199771
80MP0002638_abnormal_pupillary_reflex1.20652803
81MP0004142_abnormal_muscle_tone1.20384102
82MP0003111_abnormal_nucleus_morphology1.20304120
83MP0004782_abnormal_surfactant_physiolog1.19335501
84MP0006036_abnormal_mitochondrial_physio1.17009162
85MP0004947_skin_inflammation1.16994832
86MP0003632_abnormal_nervous_system1.16924547
87MP0004858_abnormal_nervous_system1.16485507
88MP0010386_abnormal_urinary_bladder1.15588191
89MP0005423_abnormal_somatic_nervous1.15479611
90MP0005387_immune_system_phenotype1.13764012
91MP0001790_abnormal_immune_system1.13764012
92MP0002234_abnormal_pharynx_morphology1.12329917
93MP0001485_abnormal_pinna_reflex1.11799342
94MP0009840_abnormal_foam_cell1.10559138
95MP0003191_abnormal_cellular_cholesterol1.10389485
96MP0003119_abnormal_digestive_system1.10169973
97MP0000467_abnormal_esophagus_morphology1.09727182
98MP0003303_peritoneal_inflammation1.09393855
99MP0005499_abnormal_olfactory_system1.09067123
100MP0005394_taste/olfaction_phenotype1.09067123
101MP0008438_abnormal_cutaneous_collagen1.08231290
102MP0008007_abnormal_cellular_replicative1.08209641
103MP0001216_abnormal_epidermal_layer1.08143811
104MP0002282_abnormal_trachea_morphology1.07546698
105MP0005408_hypopigmentation1.07000210
106MP0000762_abnormal_tongue_morphology1.06672225
107MP0003195_calcinosis1.06341840
108MP0002064_seizures1.06234509
109MP0000026_abnormal_inner_ear1.06075955
110MP0000516_abnormal_urinary_system1.05806327
111MP0005367_renal/urinary_system_phenotyp1.05806327
112MP0005164_abnormal_response_to1.05336650
113MP0005310_abnormal_salivary_gland1.04719536
114MP0002163_abnormal_gland_morphology1.04404415
115MP0006035_abnormal_mitochondrial_morpho1.03696056
116MP0003567_abnormal_fetal_cardiomyocyte1.03445113
117MP0001286_abnormal_eye_development1.02893039
118MP0000427_abnormal_hair_cycle1.02784623
119MP0010030_abnormal_orbit_morphology1.01291900
120MP0005551_abnormal_eye_electrophysiolog1.00546905
121MP0004885_abnormal_endolymph1.00028466
122MP0001486_abnormal_startle_reflex0.99976965
123MP0000631_abnormal_neuroendocrine_gland0.99225929
124MP0002751_abnormal_autonomic_nervous0.97907523
125MP0003075_altered_response_to0.97625116
126MP0001440_abnormal_grooming_behavior0.96104593
127* MP0005501_abnormal_skin_physiology0.95535515
128MP0005391_vision/eye_phenotype0.93165854
129MP0003786_premature_aging0.92616393
130MP0002233_abnormal_nose_morphology0.92177598
131MP0001970_abnormal_pain_threshold0.92105899
132MP0006276_abnormal_autonomic_nervous0.91630195
133MP0002733_abnormal_thermal_nociception0.91131477
134MP0001727_abnormal_embryo_implantation0.89876840
135MP0010307_abnormal_tumor_latency0.89160951
136MP0001533_abnormal_skeleton_physiology0.89096218
137MP0002697_abnormal_eye_size0.88476080
138MP0005174_abnormal_tail_pigmentation0.87049959
139* MP0010771_integument_phenotype0.86774604
140MP0003186_abnormal_redox_activity0.86597521
141MP0001984_abnormal_olfaction0.86099090
142MP0002272_abnormal_nervous_system0.85710110
143MP0002723_abnormal_immune_serum0.85667113
144MP0002734_abnormal_mechanical_nocicepti0.85523683
145MP0005257_abnormal_intraocular_pressure0.85401225
146MP0002938_white_spotting0.84707807
147MP0002998_abnormal_bone_remodeling0.84359309
148MP0003448_altered_tumor_morphology0.83892200
149MP0000377_abnormal_hair_follicle0.83004663
150MP0000538_abnormal_urinary_bladder0.82669971
151MP0002452_abnormal_antigen_presenting0.82513570
152MP0003755_abnormal_palate_morphology0.80675336
153MP0001188_hyperpigmentation0.80075115
154MP0005195_abnormal_posterior_eye0.80016264
155MP0005379_endocrine/exocrine_gland_phen0.79127281
156MP0002229_neurodegeneration0.78094492
157MP0009697_abnormal_copulation0.77977796
158MP0002102_abnormal_ear_morphology0.77532025
159MP0008877_abnormal_DNA_methylation0.76605971
160MP0001764_abnormal_homeostasis0.76236496
161MP0003631_nervous_system_phenotype0.75898033
162MP0009046_muscle_twitch0.75187937
163MP0005187_abnormal_penis_morphology0.74027347
164MP0003938_abnormal_ear_development0.73320327
165MP0001340_abnormal_eyelid_morphology0.72326871
166MP0002084_abnormal_developmental_patter0.71733542
167MP0001963_abnormal_hearing_physiology0.71214058
168MP0001177_atelectasis0.69200945
169MP0002085_abnormal_embryonic_tissue0.69125569
170MP0002210_abnormal_sex_determination0.68832525
171MP0004019_abnormal_vitamin_homeostasis0.67445168

Predicted human phenotypes

RankGene SetZ-score
1Parakeratosis (HP:0001036)6.29110966
2Congenital nonbullous ichthyosiform erythroderma (HP:0007479)5.87830589
3Neurofibrillary tangles (HP:0002185)4.81367197
4Congenital ichthyosiform erythroderma (HP:0007431)4.80917263
5Thick nail (HP:0001805)4.65916981
6Oral leukoplakia (HP:0002745)4.54514088
7Abnormality of glycolysis (HP:0004366)4.02673490
8Increased serum pyruvate (HP:0003542)4.02673490
9Recurrent bacterial skin infections (HP:0005406)3.85867230
10Recurrent abscess formation (HP:0002722)3.65222302
11Eczematoid dermatitis (HP:0000976)3.64119697
12Abnormality of nail color (HP:0100643)3.57774232
13Acute necrotizing encephalopathy (HP:0006965)3.54006070
14Axonal loss (HP:0003447)3.45457156
15Abnormality of macrophages (HP:0004311)3.44201195
16Abnormality of the axillary hair (HP:0100134)3.39153594
17Abnormality of secondary sexual hair (HP:0009888)3.39153594
18Congenital, generalized hypertrichosis (HP:0004540)3.38998488
19Erythroderma (HP:0001019)3.37522742
20Cerebral inclusion bodies (HP:0100314)3.35765671
21Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.31043215
22Degeneration of the lateral corticospinal tracts (HP:0002314)3.31043215
23Renal Fanconi syndrome (HP:0001994)3.23293251
24Supranuclear gaze palsy (HP:0000605)3.22583135
25Sensory axonal neuropathy (HP:0003390)3.21889449
26Increased hepatocellular lipid droplets (HP:0006565)2.98084212
27Progressive macrocephaly (HP:0004481)2.97109179
28Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.95485559
29Leukodystrophy (HP:0002415)2.88480549
30Abnormal mitochondria in muscle tissue (HP:0008316)2.87757988
31Hepatosplenomegaly (HP:0001433)2.85390758
32Peripheral hypomyelination (HP:0007182)2.84704990
33Mitochondrial inheritance (HP:0001427)2.82609443
34Increased neuronal autofluorescent lipopigment (HP:0002074)2.78800219
35Fragile nails (HP:0001808)2.74730774
36Recurrent gram-negative bacterial infections (HP:0005420)2.73139973
37Hypotrichosis (HP:0001006)2.71645533
38Increased cerebral lipofuscin (HP:0011813)2.68987529
39Segmental peripheral demyelination/remyelination (HP:0003481)2.66565555
40Recurrent skin infections (HP:0001581)2.63125323
41Gastrointestinal atresia (HP:0002589)2.60687541
42Colon cancer (HP:0003003)2.60384928
43Myokymia (HP:0002411)2.57829080
44Acute encephalopathy (HP:0006846)2.54737716
45Sparse eyelashes (HP:0000653)2.50939797
46Intestinal atresia (HP:0011100)2.47653155
47Multiple enchondromatosis (HP:0005701)2.47452951
48Vacuolated lymphocytes (HP:0001922)2.45727629
49True hermaphroditism (HP:0010459)2.45463595
50Esophageal atresia (HP:0002032)2.44539021
51Lipid accumulation in hepatocytes (HP:0006561)2.41888198
52Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.41793090
53Cerebral edema (HP:0002181)2.41400790
54Palmoplantar hyperkeratosis (HP:0000972)2.38215016
55Abnormality of the labia minora (HP:0012880)2.36462739
56Amniotic constriction ring (HP:0009775)2.35717571
57Abnormality of placental membranes (HP:0011409)2.35717571
58Methylmalonic acidemia (HP:0002912)2.35387158
59Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.32951277
60Plantar hyperkeratosis (HP:0007556)2.31415123
61Cerebral hemorrhage (HP:0001342)2.27925894
62Abnormality of the corticospinal tract (HP:0002492)2.27765632
63Woolly hair (HP:0002224)2.27417021
64Chronic obstructive pulmonary disease (HP:0006510)2.27310843
65Obstructive lung disease (HP:0006536)2.27310843
66Furrowed tongue (HP:0000221)2.26043347
67Disinhibition (HP:0000734)2.25630547
68Erythema (HP:0010783)2.21497029
693-Methylglutaconic aciduria (HP:0003535)2.16949956
70Hepatic necrosis (HP:0002605)2.16662861
71Absent hair (HP:0002298)2.16562404
72Elevated erythrocyte sedimentation rate (HP:0003565)2.15719885
73Palmar hyperkeratosis (HP:0010765)2.14927316
74Increased serum lactate (HP:0002151)2.09846740
75Methylmalonic aciduria (HP:0012120)2.08211663
76Meckel diverticulum (HP:0002245)2.08040072
77Conical tooth (HP:0000698)2.07584387
78Onion bulb formation (HP:0003383)2.07575945
79Exertional dyspnea (HP:0002875)2.07137001
80Aplasia cutis congenita (HP:0001057)2.06296243
81Clumsiness (HP:0002312)2.05152493
82Increased IgE level (HP:0003212)2.04865958
83Absent septum pellucidum (HP:0001331)2.04416109
84Abnormal number of erythroid precursors (HP:0012131)2.04374427
85Prolonged neonatal jaundice (HP:0006579)2.03000365
86Split foot (HP:0001839)2.00542201
87Abnormal lung lobation (HP:0002101)2.00509493
88Alopecia of scalp (HP:0002293)1.99957491
89Respiratory difficulties (HP:0002880)1.99590668
90Hypoplastic pelvis (HP:0008839)1.98298176
91Lactic acidosis (HP:0003128)1.97939693
92Stenosis of the external auditory canal (HP:0000402)1.96045522
93Slow saccadic eye movements (HP:0000514)1.95537626
94White forelock (HP:0002211)1.94870242
95Conjunctival hamartoma (HP:0100780)1.94667602
96Abnormality of the ileum (HP:0001549)1.94479135
97Onycholysis (HP:0001806)1.94404200
98Hypergammaglobulinemia (HP:0010702)1.94229209
99Anomalous pulmonary venous return (HP:0010772)1.94220461
100Alacrima (HP:0000522)1.94182616
101Neoplasm of the adrenal gland (HP:0100631)1.93713062
102Peripheral demyelination (HP:0011096)1.92766721
103Patchy hypopigmentation of hair (HP:0011365)1.92315715
104Hepatocellular necrosis (HP:0001404)1.92246177
105Medulloblastoma (HP:0002885)1.92107552
106Autoamputation (HP:0001218)1.92071393
107Increased CSF lactate (HP:0002490)1.91509622
108Poor head control (HP:0002421)1.91317103
109Corneal dystrophy (HP:0001131)1.91053792
110Aplasia involving bones of the extremities (HP:0009825)1.89925441
111Aplasia involving bones of the upper limbs (HP:0009823)1.89925441
112Aplasia of the phalanges of the hand (HP:0009802)1.89925441
113Abnormality of midbrain morphology (HP:0002418)1.88238066
114Molar tooth sign on MRI (HP:0002419)1.88238066
115Loss of speech (HP:0002371)1.87525671
116Follicular hyperkeratosis (HP:0007502)1.87365405
117Abnormality of the anterior horn cell (HP:0006802)1.87342972
118Degeneration of anterior horn cells (HP:0002398)1.87342972
119Urticaria (HP:0001025)1.87299817
120Abnormality of the septum pellucidum (HP:0007375)1.86813414
121Abnormality of alanine metabolism (HP:0010916)1.85784006
122Hyperalaninemia (HP:0003348)1.85784006
123Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.85784006
124Purpura (HP:0000979)1.85646925
125Bilateral microphthalmos (HP:0007633)1.84767681
126Humeroradial synostosis (HP:0003041)1.84732087
127Synostosis involving the elbow (HP:0003938)1.84732087
128Optic disc pallor (HP:0000543)1.84578569
129Sclerocornea (HP:0000647)1.84013504
130Pancreatic fibrosis (HP:0100732)1.83693922
131Nail dystrophy (HP:0008404)1.83566155
132Abnormal umbilical cord blood vessels (HP:0011403)1.83113342
133Single umbilical artery (HP:0001195)1.83113342
134Abnormality of the fetal cardiovascular system (HP:0010948)1.83113342
135Megalencephaly (HP:0001355)1.83076103
136Abnormality of renal resorption (HP:0011038)1.82813076
137Increased intramyocellular lipid droplets (HP:0012240)1.82635322
138Akinesia (HP:0002304)1.82576959
139Septo-optic dysplasia (HP:0100842)1.81943665
140Respiratory failure (HP:0002878)1.81025478
141Decreased activity of mitochondrial respiratory chain (HP:0008972)1.80921202
142Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.80921202
143Recurrent corneal erosions (HP:0000495)1.80889106
144Macrocytic anemia (HP:0001972)1.80402149
145Bone cyst (HP:0012062)1.79916455
146Pancreatic cysts (HP:0001737)1.79745683
147Abnormality of liposaccharide metabolism (HP:0010968)1.79489066
148Abnormality of glycosphingolipid metabolism (HP:0004343)1.79489066
149Abnormality of glycolipid metabolism (HP:0010969)1.79489066
150Partial duplication of thumb phalanx (HP:0009944)1.79029014
151Hemivertebrae (HP:0002937)1.77697467
152Abnormality of the preputium (HP:0100587)1.77688430
153Aplasia/Hypoplasia of the uvula (HP:0010293)1.72955215
154Abnormality of cells of the erythroid lineage (HP:0012130)1.72924854
155Reticulocytopenia (HP:0001896)1.72878977
156Abnormality of serum amino acid levels (HP:0003112)1.72458079
157Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.71610967
158Agnosia (HP:0010524)1.71401017
159Cortical dysplasia (HP:0002539)1.70709384
160Exercise intolerance (HP:0003546)1.68996477
161Abnormality of chromosome stability (HP:0003220)1.68642892
162Adrenal hypoplasia (HP:0000835)1.68308258
163Anophthalmia (HP:0000528)1.67644995
164Rib fusion (HP:0000902)1.67307579
165Triphalangeal thumb (HP:0001199)1.66050417
166Neuroendocrine neoplasm (HP:0100634)1.63952997

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TSSK64.70000015
2PBK4.60472551
3PNCK3.86808169
4STK393.86395040
5WEE13.74984264
6EPHB13.34734689
7BCR3.31370296
8MST43.00067368
9PLK42.98066772
10VRK22.88848243
11MKNK22.81228195
12BUB12.79146034
13LIMK12.70851315
14NEK12.69049307
15PKN12.49325839
16MAPK152.35988930
17VRK12.31157634
18OXSR12.21062642
19DYRK22.20372366
20MKNK12.16724803
21WNK32.07570155
22MAP4K22.01547932
23SRPK12.01278506
24ARAF1.99807476
25MAP3K141.89314616
26BLK1.85862815
27PLK31.82719999
28TGFBR11.82571731
29BMPR1B1.80885802
30BRSK21.76807443
31NME21.76604569
32EIF2AK31.74889550
33MAPKAPK51.74489920
34MARK11.73634909
35CSNK1G31.71960595
36CDC71.68412069
37FGR1.67105564
38STK161.64731472
39ACVR1B1.58685784
40INSRR1.55625876
41TTK1.51890988
42ZAK1.51222525
43MST1R1.49260956
44TRIM281.43901741
45WNK41.43687678
46PIM21.43632926
47UHMK11.42067645
48ABL21.41462242
49RIPK41.39548843
50CSNK1A1L1.38490145
51MET1.37797878
52NME11.33985471
53IRAK41.32843362
54FGFR21.32331263
55CDK191.28395463
56NUAK11.24782283
57CSNK1G11.24646550
58GRK71.24269378
59CASK1.23485729
60MAPK131.21629105
61TAF11.19778750
62DYRK31.17795288
63TESK21.15094114
64CSNK1G21.13302101
65ROCK21.12627019
66IKBKB1.12297433
67NTRK21.12220048
68EPHB21.10462047
69CLK11.05781812
70TBK11.04947324
71NTRK11.04495988
72PDK21.03547104
73PLK10.98549365
74CAMKK20.96701874
75TNIK0.92311555
76CAMK2B0.88356258
77EPHA30.88316690
78ILK0.87698104
79TYK20.87452450
80IRAK20.82874987
81PRKCQ0.80177765
82YES10.79832734
83BMPR20.79299294
84PRKCE0.78761525
85CDK30.78686500
86GRK10.78303600
87EIF2AK10.77856304
88GRK50.75726607
89TIE10.75272092
90TESK10.73929559
91ERBB40.72240177
92IRAK10.68845488
93BMX0.68728095
94CDK140.66139766
95FGFR10.64244431
96MAP3K130.62343020
97RPS6KA50.62178172
98MUSK0.61924389
99TRPM70.59876756
100PRKCG0.59585472
101ADRBK10.58617233
102CAMK1D0.58237267
103LRRK20.56673443
104CDK50.56341567
105MAP3K120.55735603
106SYK0.55686948
107WNK10.54194494
108CAMK2D0.54194130
109FYN0.53672202
110RPS6KA40.53526995
111CAMK2G0.53364315
112MAP2K20.53351955
113PAK60.53068795
114GSK3A0.52287957
115DAPK30.51959556
116CAMK2A0.51629660
117BRSK10.51074623
118PAK10.51005809
119CDK150.50196604
120MOS0.50121861
121PAK40.48691685
122PRKCD0.47936778
123PHKG10.47895183
124PHKG20.47895183
125CDK180.47413714
126TLK10.47397604
127AURKB0.46172182
128CSNK2A10.46082349
129CDK11A0.45126539
130STK100.44982892
131ADRBK20.44433929
132ATR0.44274267
133CHEK20.43636387
134ERBB30.42740197
135ABL10.41051954
136BCKDK0.40618195
137STK38L0.40505276
138IKBKE0.40184967
139LYN0.40091109
140NEK60.38966976
141LCK0.38527492
142MAPKAPK20.38326663
143EIF2AK20.38022658
144HCK0.38013040
145KSR20.36909850
146PAK30.36886593
147PRKD10.36266374
148CSNK2A20.36191861
149PLK20.35147459
150MAP3K40.34843326
151ATM0.34171829
152NEK20.34135871
153PRKG10.33771888
154CSNK1E0.32313404
155MAP3K80.31219057
156ALK0.29699437
157MAP2K70.29128354
158CSNK1A10.28919676
159CAMK1G0.27879591
160PINK10.27190941
161STK40.26639742
162STK30.25668610
163MAPKAPK30.23943582
164PASK0.22579660
165FER0.20816870
166AURKA0.19684788
167CHEK10.18778146

Predicted pathways (KEGG)

RankGene SetZ-score
1Steroid biosynthesis_Homo sapiens_hsa001004.87743010
2Terpenoid backbone biosynthesis_Homo sapiens_hsa009004.67348175
3Oxidative phosphorylation_Homo sapiens_hsa001903.78634426
4Fatty acid elongation_Homo sapiens_hsa000623.51214814
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.00614970
6Parkinsons disease_Homo sapiens_hsa050122.84004599
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.63652408
8Mismatch repair_Homo sapiens_hsa034302.54319129
9Proteasome_Homo sapiens_hsa030502.41854177
10Alzheimers disease_Homo sapiens_hsa050102.37523543
11Collecting duct acid secretion_Homo sapiens_hsa049662.32349667
12Ether lipid metabolism_Homo sapiens_hsa005652.31869811
13Rheumatoid arthritis_Homo sapiens_hsa053232.28119106
14DNA replication_Homo sapiens_hsa030302.21776394
15Homologous recombination_Homo sapiens_hsa034402.12748446
16Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.99948224
17Spliceosome_Homo sapiens_hsa030401.97357872
18Ribosome_Homo sapiens_hsa030101.96827125
19Phagosome_Homo sapiens_hsa041451.95161304
20Graft-versus-host disease_Homo sapiens_hsa053321.94677229
21Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.85643836
22Basal transcription factors_Homo sapiens_hsa030221.84307811
23Huntingtons disease_Homo sapiens_hsa050161.73125783
24Sphingolipid metabolism_Homo sapiens_hsa006001.68925638
25Non-homologous end-joining_Homo sapiens_hsa034501.66936252
26Propanoate metabolism_Homo sapiens_hsa006401.62010395
27Nucleotide excision repair_Homo sapiens_hsa034201.60822966
28Lysosome_Homo sapiens_hsa041421.59410798
29Folate biosynthesis_Homo sapiens_hsa007901.56826182
30RNA degradation_Homo sapiens_hsa030181.56194062
31Protein export_Homo sapiens_hsa030601.55632422
32Allograft rejection_Homo sapiens_hsa053301.55221637
33Fanconi anemia pathway_Homo sapiens_hsa034601.52842884
34RNA transport_Homo sapiens_hsa030131.50799517
35Base excision repair_Homo sapiens_hsa034101.49037908
36Linoleic acid metabolism_Homo sapiens_hsa005911.41433579
37alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.41358556
38Histidine metabolism_Homo sapiens_hsa003401.40636919
39Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.34731176
40Malaria_Homo sapiens_hsa051441.34440167
41Pyruvate metabolism_Homo sapiens_hsa006201.32940309
42Pyrimidine metabolism_Homo sapiens_hsa002401.32826162
43One carbon pool by folate_Homo sapiens_hsa006701.29008164
44Asthma_Homo sapiens_hsa053101.27467652
45Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.26062009
46SNARE interactions in vesicular transport_Homo sapiens_hsa041301.25844953
47Vibrio cholerae infection_Homo sapiens_hsa051101.22618559
48Autoimmune thyroid disease_Homo sapiens_hsa053201.19438479
49Cysteine and methionine metabolism_Homo sapiens_hsa002701.18153702
50Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.16982278
51Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.15016678
52Axon guidance_Homo sapiens_hsa043601.13622122
53Pertussis_Homo sapiens_hsa051331.12334039
54Purine metabolism_Homo sapiens_hsa002301.08772477
55Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.07810780
56Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.06962951
57Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.06228092
58Cell cycle_Homo sapiens_hsa041101.03836219
59Arachidonic acid metabolism_Homo sapiens_hsa005901.03073211
60Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.01140202
61Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.99010830
62Phototransduction_Homo sapiens_hsa047440.97704211
63Leishmaniasis_Homo sapiens_hsa051400.92004762
64Tuberculosis_Homo sapiens_hsa051520.90545813
65Cardiac muscle contraction_Homo sapiens_hsa042600.90532738
66Staphylococcus aureus infection_Homo sapiens_hsa051500.90042715
67Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.88923720
68Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.88363940
69NOD-like receptor signaling pathway_Homo sapiens_hsa046210.86813987
70Sphingolipid signaling pathway_Homo sapiens_hsa040710.86449746
71Serotonergic synapse_Homo sapiens_hsa047260.85945458
72Selenocompound metabolism_Homo sapiens_hsa004500.85880034
73Nitrogen metabolism_Homo sapiens_hsa009100.83501418
74Sulfur relay system_Homo sapiens_hsa041220.83111990
75Basal cell carcinoma_Homo sapiens_hsa052170.81744360
76Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.79535996
77Salmonella infection_Homo sapiens_hsa051320.79297640
78African trypanosomiasis_Homo sapiens_hsa051430.78861807
79Toll-like receptor signaling pathway_Homo sapiens_hsa046200.77338744
80Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.69948101
81Osteoclast differentiation_Homo sapiens_hsa043800.69380448
82Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.68902120
83Renal cell carcinoma_Homo sapiens_hsa052110.68804388
84Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.67960991
85Tyrosine metabolism_Homo sapiens_hsa003500.66125127
86Phenylalanine metabolism_Homo sapiens_hsa003600.65865027
87NF-kappa B signaling pathway_Homo sapiens_hsa040640.65375269
88TGF-beta signaling pathway_Homo sapiens_hsa043500.62116797
89Tryptophan metabolism_Homo sapiens_hsa003800.61790147
90Type I diabetes mellitus_Homo sapiens_hsa049400.60082143
91Primary bile acid biosynthesis_Homo sapiens_hsa001200.59217863
92Chemokine signaling pathway_Homo sapiens_hsa040620.59014984
932-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.57802644
94Sulfur metabolism_Homo sapiens_hsa009200.56702618
95Fatty acid degradation_Homo sapiens_hsa000710.55827356
96Glutathione metabolism_Homo sapiens_hsa004800.55456941
97Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.54209152
98Synaptic vesicle cycle_Homo sapiens_hsa047210.51981869
99beta-Alanine metabolism_Homo sapiens_hsa004100.51861555
100Mineral absorption_Homo sapiens_hsa049780.51234491
101Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.51220818
102Carbon metabolism_Homo sapiens_hsa012000.50813154
103mRNA surveillance pathway_Homo sapiens_hsa030150.50796123
104Hedgehog signaling pathway_Homo sapiens_hsa043400.50594943
105p53 signaling pathway_Homo sapiens_hsa041150.49313007
106Oocyte meiosis_Homo sapiens_hsa041140.49188516
107Apoptosis_Homo sapiens_hsa042100.48810145
108Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.46670644
109Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.46485523
110Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.45976484
111Ras signaling pathway_Homo sapiens_hsa040140.44343617
112Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.43881701
113Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.43173460
114Legionellosis_Homo sapiens_hsa051340.42986583
115Dorso-ventral axis formation_Homo sapiens_hsa043200.42757339
116Shigellosis_Homo sapiens_hsa051310.42199307
117RNA polymerase_Homo sapiens_hsa030200.41728343
118Arginine and proline metabolism_Homo sapiens_hsa003300.39144160
119Pentose and glucuronate interconversions_Homo sapiens_hsa000400.37976683
120Chemical carcinogenesis_Homo sapiens_hsa052040.37531580
121Intestinal immune network for IgA production_Homo sapiens_hsa046720.37371531
122Fatty acid metabolism_Homo sapiens_hsa012120.37141697
123Endocytosis_Homo sapiens_hsa041440.36273332
124Viral myocarditis_Homo sapiens_hsa054160.36038413
125Hepatitis C_Homo sapiens_hsa051600.34985238
126Glutamatergic synapse_Homo sapiens_hsa047240.34478653
127Fatty acid biosynthesis_Homo sapiens_hsa000610.34455728
128TNF signaling pathway_Homo sapiens_hsa046680.34388427
129Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.34273004
130Toxoplasmosis_Homo sapiens_hsa051450.34260750
131Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.34239221
132Retinol metabolism_Homo sapiens_hsa008300.33722543
133Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.33697126
134Butanoate metabolism_Homo sapiens_hsa006500.33478714
135Maturity onset diabetes of the young_Homo sapiens_hsa049500.32529693
136Long-term depression_Homo sapiens_hsa047300.31057889
137* PPAR signaling pathway_Homo sapiens_hsa033200.30909361
138Hematopoietic cell lineage_Homo sapiens_hsa046400.30060013
139Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.29742757
140Ovarian steroidogenesis_Homo sapiens_hsa049130.28573103
141Amoebiasis_Homo sapiens_hsa051460.28088353
142Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.26722738
143Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.25255892
144Metabolic pathways_Homo sapiens_hsa011000.24499727
145Phospholipase D signaling pathway_Homo sapiens_hsa040720.24105584
146Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.23891298
147RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.22987891
148Prion diseases_Homo sapiens_hsa050200.22765293
149Fat digestion and absorption_Homo sapiens_hsa049750.21594517
150Antigen processing and presentation_Homo sapiens_hsa046120.21529772
151Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.21259582
152Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.19712491
153Vitamin B6 metabolism_Homo sapiens_hsa007500.19569528
154Regulation of actin cytoskeleton_Homo sapiens_hsa048100.19491807
155Regulation of autophagy_Homo sapiens_hsa041400.19129466
156Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.18898647
157Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.18738891
158GABAergic synapse_Homo sapiens_hsa047270.18726683
159Peroxisome_Homo sapiens_hsa041460.18545636
160Cholinergic synapse_Homo sapiens_hsa047250.18367068
161Glycerolipid metabolism_Homo sapiens_hsa005610.17333192

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