

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | DNA deamination (GO:0045006) | 8.04329787 |
| 2 | cytidine deamination (GO:0009972) | 6.75747130 |
| 3 | cytidine metabolic process (GO:0046087) | 6.75747130 |
| 4 | cytidine catabolic process (GO:0006216) | 6.75747130 |
| 5 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 6.63521820 |
| 6 | pyrimidine ribonucleoside catabolic process (GO:0046133) | 5.79444190 |
| 7 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 4.98925320 |
| 8 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 4.84320114 |
| 9 | proteasome assembly (GO:0043248) | 4.76394558 |
| 10 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 4.53084645 |
| 11 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 4.45399643 |
| 12 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 4.44264170 |
| 13 | regulation of cellular amino acid metabolic process (GO:0006521) | 4.37240065 |
| 14 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 4.34312227 |
| 15 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 4.34312227 |
| 16 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 4.32745983 |
| 17 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 4.32745983 |
| 18 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 4.32745983 |
| 19 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 4.23515842 |
| 20 | ATP synthesis coupled proton transport (GO:0015986) | 4.23515842 |
| 21 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 4.22301607 |
| 22 | chaperone-mediated protein transport (GO:0072321) | 4.13943491 |
| 23 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 4.11778124 |
| 24 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 4.11778124 |
| 25 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 4.11146560 |
| 26 | respiratory electron transport chain (GO:0022904) | 4.09577937 |
| 27 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 4.09181521 |
| 28 | negative regulation of ligase activity (GO:0051352) | 4.09181521 |
| 29 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 4.05706060 |
| 30 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 4.03405115 |
| 31 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 4.03405115 |
| 32 | deoxyribonucleoside triphosphate metabolic process (GO:0009200) | 4.01911371 |
| 33 | electron transport chain (GO:0022900) | 4.01113255 |
| 34 | protein complex biogenesis (GO:0070271) | 3.98377020 |
| 35 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.96679591 |
| 36 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 3.92441403 |
| 37 | negative regulation of B cell apoptotic process (GO:0002903) | 3.80446570 |
| 38 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.78330570 |
| 39 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.75392695 |
| 40 | Arp2/3 complex-mediated actin nucleation (GO:0034314) | 3.73551661 |
| 41 | sequestering of actin monomers (GO:0042989) | 3.68754780 |
| 42 | antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590) | 3.68377407 |
| 43 | purine deoxyribonucleotide catabolic process (GO:0009155) | 3.63512163 |
| 44 | telomere maintenance via semi-conservative replication (GO:0032201) | 3.60566883 |
| 45 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.58838148 |
| 46 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.58838148 |
| 47 | NADH dehydrogenase complex assembly (GO:0010257) | 3.58838148 |
| 48 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.55638568 |
| 49 | negative regulation by host of viral transcription (GO:0043922) | 3.48420571 |
| 50 | DNA double-strand break processing (GO:0000729) | 3.44441912 |
| 51 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.41289231 |
| 52 | positive regulation of ligase activity (GO:0051351) | 3.39200767 |
| 53 | DNA damage response, signal transduction by p53 class mediator (GO:0030330) | 3.38374896 |
| 54 | purine deoxyribonucleoside triphosphate metabolic process (GO:0009215) | 3.35399123 |
| 55 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.33740637 |
| 56 | positive regulation of cell cycle arrest (GO:0071158) | 3.33373453 |
| 57 | purine nucleotide salvage (GO:0032261) | 3.32667063 |
| 58 | deoxyribonucleotide catabolic process (GO:0009264) | 3.28272355 |
| 59 | deoxyribose phosphate catabolic process (GO:0046386) | 3.24367510 |
| 60 | telomere maintenance via recombination (GO:0000722) | 3.23801392 |
| 61 | regulation of cellular amine metabolic process (GO:0033238) | 3.16716865 |
| 62 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 3.12956009 |
| 63 | deoxyribose phosphate biosynthetic process (GO:0046385) | 3.12121013 |
| 64 | 2-deoxyribonucleotide biosynthetic process (GO:0009265) | 3.12121013 |
| 65 | oxidative phosphorylation (GO:0006119) | 3.10818836 |
| 66 | actin nucleation (GO:0045010) | 3.10027471 |
| 67 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 3.08367381 |
| 68 | purine-containing compound salvage (GO:0043101) | 3.07918220 |
| 69 | mitotic recombination (GO:0006312) | 3.05843582 |
| 70 | pyrimidine deoxyribonucleotide metabolic process (GO:0009219) | 3.02587212 |
| 71 | platelet dense granule organization (GO:0060155) | 3.02471397 |
| 72 | DNA strand elongation involved in DNA replication (GO:0006271) | 3.02161436 |
| 73 | nucleotide-excision repair, DNA gap filling (GO:0006297) | 2.96769084 |
| 74 | regulation of ligase activity (GO:0051340) | 2.96596503 |
| 75 | 2-deoxyribonucleotide metabolic process (GO:0009394) | 2.96064101 |
| 76 | DNA ligation (GO:0006266) | 2.94804030 |
| 77 | negative regulation of G1/S transition of mitotic cell cycle (GO:2000134) | 2.93327377 |
| 78 | negative regulation of cell cycle G1/S phase transition (GO:1902807) | 2.93327377 |
| 79 | regulation of mitochondrial translation (GO:0070129) | 2.93269407 |
| 80 | regulation of penile erection (GO:0060405) | 2.92250351 |
| 81 | purine deoxyribonucleotide metabolic process (GO:0009151) | 2.90764074 |
| 82 | mismatch repair (GO:0006298) | 2.90127057 |
| 83 | antigen processing and presentation of peptide antigen via MHC class I (GO:0002474) | 2.89787968 |
| 84 | deoxyribose phosphate metabolic process (GO:0019692) | 2.89470455 |
| 85 | DNA strand elongation (GO:0022616) | 2.88169901 |
| 86 | metallo-sulfur cluster assembly (GO:0031163) | 2.87958694 |
| 87 | iron-sulfur cluster assembly (GO:0016226) | 2.87958694 |
| 88 | pyrimidine nucleoside catabolic process (GO:0046135) | 2.86049747 |
| 89 | signal transduction in response to DNA damage (GO:0042770) | 2.84406694 |
| 90 | protein neddylation (GO:0045116) | 2.82140850 |
| 91 | negative regulation of protein ubiquitination (GO:0031397) | 2.81934540 |
| 92 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 2.80912019 |
| 93 | termination of RNA polymerase III transcription (GO:0006386) | 2.80912019 |
| 94 | deoxyribonucleotide biosynthetic process (GO:0009263) | 2.80383220 |
| 95 | regulation of cell cycle arrest (GO:0071156) | 2.78541131 |
| 96 | telomere maintenance via telomere lengthening (GO:0010833) | 2.75929617 |
| 97 | deoxyribonucleotide metabolic process (GO:0009262) | 2.75844341 |
| 98 | protein targeting to mitochondrion (GO:0006626) | 2.72741372 |
| 99 | purine nucleobase biosynthetic process (GO:0009113) | 2.72737512 |
| 100 | DNA demethylation (GO:0080111) | 2.71844270 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E2F7_22180533_ChIP-Seq_HELA_Human | 5.12879361 |
| 2 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 4.97043399 |
| 3 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.71415355 |
| 4 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.04298755 |
| 5 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 3.96209374 |
| 6 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 3.92662232 |
| 7 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.52150101 |
| 8 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 3.33116678 |
| 9 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.32589087 |
| 10 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.81509881 |
| 11 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 2.81023435 |
| 12 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.77034105 |
| 13 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.72745117 |
| 14 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.72551031 |
| 15 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.72042946 |
| 16 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.66711504 |
| 17 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 2.65062755 |
| 18 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 2.52619156 |
| 19 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 2.42563499 |
| 20 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.31554910 |
| 21 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 2.30753645 |
| 22 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.29339494 |
| 23 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.27604345 |
| 24 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.24135002 |
| 25 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.22563321 |
| 26 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 2.17760290 |
| 27 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.15105400 |
| 28 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 2.09637730 |
| 29 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 1.99376662 |
| 30 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.94464381 |
| 31 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.86235823 |
| 32 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.85209957 |
| 33 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.84706808 |
| 34 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.82590836 |
| 35 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.79246272 |
| 36 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 1.67181830 |
| 37 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 1.65088948 |
| 38 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.63152980 |
| 39 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.61499775 |
| 40 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.60139325 |
| 41 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.56237787 |
| 42 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.54032726 |
| 43 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.51418670 |
| 44 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.48079601 |
| 45 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.43478673 |
| 46 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.41323002 |
| 47 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 1.38987220 |
| 48 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.36836412 |
| 49 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.36641729 |
| 50 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.36128074 |
| 51 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.36088404 |
| 52 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.34899834 |
| 53 | MYB_26560356_Chip-Seq_TH2_Human | 1.34383167 |
| 54 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.33157052 |
| 55 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.30968325 |
| 56 | SPI1_23547873_ChIP-Seq_NB4_Human | 1.24509519 |
| 57 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.22178518 |
| 58 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.19522873 |
| 59 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.17889433 |
| 60 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.13438539 |
| 61 | GATA3_26560356_Chip-Seq_TH2_Human | 1.12066956 |
| 62 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.10684064 |
| 63 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.10659683 |
| 64 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.09651323 |
| 65 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.07072298 |
| 66 | VDR_22108803_ChIP-Seq_LS180_Human | 1.06259710 |
| 67 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.04512291 |
| 68 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 1.04454565 |
| 69 | HTT_18923047_ChIP-ChIP_STHdh_Human | 1.02134997 |
| 70 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 1.00764548 |
| 71 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.00201723 |
| 72 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 0.99708256 |
| 73 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 0.98948786 |
| 74 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 0.98473284 |
| 75 | ERG_20517297_ChIP-Seq_VCAP_Human | 0.98153653 |
| 76 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 0.97963637 |
| 77 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 0.97355782 |
| 78 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 0.96603096 |
| 79 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.96600400 |
| 80 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.95979886 |
| 81 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 0.95335397 |
| 82 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.93134600 |
| 83 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 0.92603952 |
| 84 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 0.92061068 |
| 85 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 0.90982831 |
| 86 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 0.89937850 |
| 87 | GATA3_27048872_Chip-Seq_THYMUS_Human | 0.88150468 |
| 88 | EWS_26573619_Chip-Seq_HEK293_Human | 0.87966795 |
| 89 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 0.87125218 |
| 90 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 0.87115641 |
| 91 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 0.87115641 |
| 92 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 0.84895096 |
| 93 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 0.84662155 |
| 94 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 0.83065394 |
| 95 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 0.82754230 |
| 96 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 0.82626993 |
| 97 | PPARD_23208498_ChIP-Seq_MDA-MB-231_Human | 0.81871797 |
| 98 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 0.77604996 |
| 99 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.77422626 |
| 100 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 0.77036461 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0005671_abnormal_response_to | 3.66655536 |
| 2 | MP0003806_abnormal_nucleotide_metabolis | 3.36191924 |
| 3 | MP0003136_yellow_coat_color | 3.31608867 |
| 4 | MP0009697_abnormal_copulation | 3.05441319 |
| 5 | MP0010094_abnormal_chromosome_stability | 2.85714933 |
| 6 | MP0008058_abnormal_DNA_repair | 2.75602593 |
| 7 | MP0004147_increased_porphyrin_level | 2.63526639 |
| 8 | MP0001835_abnormal_antigen_presentation | 2.55275335 |
| 9 | MP0005084_abnormal_gallbladder_morpholo | 2.54327879 |
| 10 | MP0003786_premature_aging | 2.34040521 |
| 11 | MP0000372_irregular_coat_pigmentation | 2.27641169 |
| 12 | MP0003763_abnormal_thymus_physiology | 2.22530034 |
| 13 | MP0002102_abnormal_ear_morphology | 2.18503070 |
| 14 | MP0002148_abnormal_hypersensitivity_rea | 2.17145442 |
| 15 | MP0002166_altered_tumor_susceptibility | 2.16065590 |
| 16 | MP0009785_altered_susceptibility_to | 2.06145315 |
| 17 | MP0006036_abnormal_mitochondrial_physio | 2.03776126 |
| 18 | MP0008877_abnormal_DNA_methylation | 1.99998049 |
| 19 | MP0002006_tumorigenesis | 1.98667641 |
| 20 | MP0009333_abnormal_splenocyte_physiolog | 1.79592659 |
| 21 | MP0004957_abnormal_blastocyst_morpholog | 1.69769012 |
| 22 | MP0006082_CNS_inflammation | 1.69299647 |
| 23 | MP0005171_absent_coat_pigmentation | 1.66288310 |
| 24 | MP0009379_abnormal_foot_pigmentation | 1.66065102 |
| 25 | MP0005645_abnormal_hypothalamus_physiol | 1.65444393 |
| 26 | MP0003693_abnormal_embryo_hatching | 1.62785346 |
| 27 | MP0003718_maternal_effect | 1.60659458 |
| 28 | MP0001800_abnormal_humoral_immune | 1.60586116 |
| 29 | MP0005000_abnormal_immune_tolerance | 1.59369657 |
| 30 | MP0005075_abnormal_melanosome_morpholog | 1.58069074 |
| 31 | MP0002420_abnormal_adaptive_immunity | 1.57838753 |
| 32 | MP0001764_abnormal_homeostasis | 1.56446346 |
| 33 | MP0008789_abnormal_olfactory_epithelium | 1.56367451 |
| 34 | MP0002396_abnormal_hematopoietic_system | 1.55966794 |
| 35 | MP0000685_abnormal_immune_system | 1.54928318 |
| 36 | MP0001905_abnormal_dopamine_level | 1.52209571 |
| 37 | MP0002398_abnormal_bone_marrow | 1.51493043 |
| 38 | MP0005025_abnormal_response_to | 1.50850281 |
| 39 | MP0001819_abnormal_immune_cell | 1.49545071 |
| 40 | MP0008007_abnormal_cellular_replicative | 1.48739451 |
| 41 | MP0006072_abnormal_retinal_apoptosis | 1.47108134 |
| 42 | MP0002723_abnormal_immune_serum | 1.41216420 |
| 43 | MP0001529_abnormal_vocalization | 1.38219761 |
| 44 | MP0000716_abnormal_immune_system | 1.37061942 |
| 45 | MP0002452_abnormal_antigen_presenting | 1.34514566 |
| 46 | MP0002822_catalepsy | 1.34467503 |
| 47 | MP0001790_abnormal_immune_system | 1.32880545 |
| 48 | MP0005387_immune_system_phenotype | 1.32880545 |
| 49 | MP0004145_abnormal_muscle_electrophysio | 1.31469496 |
| 50 | MP0002234_abnormal_pharynx_morphology | 1.30945024 |
| 51 | MP0002163_abnormal_gland_morphology | 1.30502016 |
| 52 | MP0003186_abnormal_redox_activity | 1.27655867 |
| 53 | MP0002019_abnormal_tumor_incidence | 1.27096238 |
| 54 | MP0008932_abnormal_embryonic_tissue | 1.26942773 |
| 55 | MP0003111_abnormal_nucleus_morphology | 1.25926581 |
| 56 | MP0003077_abnormal_cell_cycle | 1.25538195 |
| 57 | MP0008872_abnormal_physiological_respon | 1.24661525 |
| 58 | MP0000689_abnormal_spleen_morphology | 1.24391316 |
| 59 | MP0002653_abnormal_ependyma_morphology | 1.22871520 |
| 60 | MP0006035_abnormal_mitochondrial_morpho | 1.18838030 |
| 61 | MP0002722_abnormal_immune_system | 1.18437783 |
| 62 | MP0002429_abnormal_blood_cell | 1.17917337 |
| 63 | MP0008873_increased_physiological_sensi | 1.14528081 |
| 64 | MP0008057_abnormal_DNA_replication | 1.14143341 |
| 65 | MP0008875_abnormal_xenobiotic_pharmacok | 1.13023241 |
| 66 | MP0005379_endocrine/exocrine_gland_phen | 1.12623231 |
| 67 | MP0003011_delayed_dark_adaptation | 1.10048221 |
| 68 | MP0001968_abnormal_touch/_nociception | 1.06155617 |
| 69 | MP0002095_abnormal_skin_pigmentation | 1.05023550 |
| 70 | MP0002405_respiratory_system_inflammati | 1.04407959 |
| 71 | MP0001853_heart_inflammation | 1.02199166 |
| 72 | MP0006292_abnormal_olfactory_placode | 0.99739494 |
| 73 | MP0002277_abnormal_respiratory_mucosa | 0.98013369 |
| 74 | MP0005389_reproductive_system_phenotype | 0.94174416 |
| 75 | MP0001485_abnormal_pinna_reflex | 0.94025170 |
| 76 | MP0000703_abnormal_thymus_morphology | 0.92992329 |
| 77 | MP0001919_abnormal_reproductive_system | 0.91710000 |
| 78 | MP0003866_abnormal_defecation | 0.91563135 |
| 79 | MP0005253_abnormal_eye_physiology | 0.91534859 |
| 80 | MP0005174_abnormal_tail_pigmentation | 0.90568945 |
| 81 | MP0009764_decreased_sensitivity_to | 0.89096778 |
| 82 | MP0002419_abnormal_innate_immunity | 0.88143424 |
| 83 | MP0002876_abnormal_thyroid_physiology | 0.87736083 |
| 84 | MP0000358_abnormal_cell_content/ | 0.85264851 |
| 85 | MP0008995_early_reproductive_senescence | 0.84641608 |
| 86 | MP0000465_gastrointestinal_hemorrhage | 0.84623826 |
| 87 | MP0000490_abnormal_crypts_of | 0.82720199 |
| 88 | MP0001873_stomach_inflammation | 0.80288330 |
| 89 | MP0001845_abnormal_inflammatory_respons | 0.79221489 |
| 90 | MP0003252_abnormal_bile_duct | 0.78750977 |
| 91 | MP0004142_abnormal_muscle_tone | 0.78101275 |
| 92 | MP0002837_dystrophic_cardiac_calcinosis | 0.77673008 |
| 93 | MP0005266_abnormal_metabolism | 0.74730820 |
| 94 | MP0009763_increased_sensitivity_to | 0.73689181 |
| 95 | MP0008469_abnormal_protein_level | 0.73143163 |
| 96 | MP0001119_abnormal_female_reproductive | 0.72508691 |
| 97 | MP0005464_abnormal_platelet_physiology | 0.72017271 |
| 98 | MP0005410_abnormal_fertilization | 0.69309944 |
| 99 | MP0005636_abnormal_mineral_homeostasis | 0.69295427 |
| 100 | MP0010386_abnormal_urinary_bladder | 0.67782999 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Acute necrotizing encephalopathy (HP:0006965) | 4.86724540 |
| 2 | Mitochondrial inheritance (HP:0001427) | 4.80440394 |
| 3 | Abnormal mitochondria in muscle tissue (HP:0008316) | 4.67166726 |
| 4 | Hepatocellular necrosis (HP:0001404) | 4.22931723 |
| 5 | Acute encephalopathy (HP:0006846) | 4.19106971 |
| 6 | Increased hepatocellular lipid droplets (HP:0006565) | 4.15889333 |
| 7 | Increased CSF lactate (HP:0002490) | 4.13134558 |
| 8 | Lipid accumulation in hepatocytes (HP:0006561) | 4.02379514 |
| 9 | Progressive macrocephaly (HP:0004481) | 3.98801139 |
| 10 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 3.98168723 |
| 11 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 3.98168723 |
| 12 | Abnormality of B cell number (HP:0010975) | 3.98163203 |
| 13 | Aplastic anemia (HP:0001915) | 3.82154239 |
| 14 | Hepatic necrosis (HP:0002605) | 3.80965633 |
| 15 | B lymphocytopenia (HP:0010976) | 3.79207507 |
| 16 | Increased intramyocellular lipid droplets (HP:0012240) | 3.75966450 |
| 17 | Severe combined immunodeficiency (HP:0004430) | 3.64095678 |
| 18 | Autoimmune hemolytic anemia (HP:0001890) | 3.45918102 |
| 19 | Increased IgM level (HP:0003496) | 3.45224837 |
| 20 | Renal Fanconi syndrome (HP:0001994) | 3.39209272 |
| 21 | Increased muscle lipid content (HP:0009058) | 3.37315692 |
| 22 | Cerebral edema (HP:0002181) | 3.23882788 |
| 23 | Autoimmune thrombocytopenia (HP:0001973) | 3.15465523 |
| 24 | Combined immunodeficiency (HP:0005387) | 3.09096024 |
| 25 | Agammaglobulinemia (HP:0004432) | 3.00674170 |
| 26 | Exertional dyspnea (HP:0002875) | 3.00227819 |
| 27 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.91930198 |
| 28 | IgG deficiency (HP:0004315) | 2.91428522 |
| 29 | Type I transferrin isoform profile (HP:0003642) | 2.87361292 |
| 30 | 3-Methylglutaconic aciduria (HP:0003535) | 2.84081276 |
| 31 | Abnormality of the prostate (HP:0008775) | 2.83207622 |
| 32 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.77783426 |
| 33 | Eosinophilia (HP:0001880) | 2.75694159 |
| 34 | Increased serum lactate (HP:0002151) | 2.74063461 |
| 35 | Lactic acidosis (HP:0003128) | 2.73904392 |
| 36 | Respiratory failure (HP:0002878) | 2.73285014 |
| 37 | Hypoproteinemia (HP:0003075) | 2.63047727 |
| 38 | Multiple enchondromatosis (HP:0005701) | 2.62418260 |
| 39 | Amyotrophic lateral sclerosis (HP:0007354) | 2.61762942 |
| 40 | Exercise intolerance (HP:0003546) | 2.60588864 |
| 41 | Thyroiditis (HP:0100646) | 2.59130884 |
| 42 | Elevated erythrocyte sedimentation rate (HP:0003565) | 2.54451957 |
| 43 | Dicarboxylic aciduria (HP:0003215) | 2.51736819 |
| 44 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 2.51736819 |
| 45 | Abnormality of T cell number (HP:0011839) | 2.51018387 |
| 46 | Cerebral palsy (HP:0100021) | 2.49833352 |
| 47 | Optic disc pallor (HP:0000543) | 2.49156578 |
| 48 | Obstructive lung disease (HP:0006536) | 2.48327809 |
| 49 | Chronic obstructive pulmonary disease (HP:0006510) | 2.48327809 |
| 50 | Granulocytopenia (HP:0001913) | 2.44417995 |
| 51 | Abnormality of eosinophils (HP:0001879) | 2.43623083 |
| 52 | Pancytopenia (HP:0001876) | 2.40815673 |
| 53 | Abnormality of T cells (HP:0002843) | 2.38617243 |
| 54 | Generalized aminoaciduria (HP:0002909) | 2.34588818 |
| 55 | Oral leukoplakia (HP:0002745) | 2.32691479 |
| 56 | Leukodystrophy (HP:0002415) | 2.31535196 |
| 57 | Respiratory difficulties (HP:0002880) | 2.30102005 |
| 58 | Panhypogammaglobulinemia (HP:0003139) | 2.25230435 |
| 59 | T lymphocytopenia (HP:0005403) | 2.21284306 |
| 60 | Progressive microcephaly (HP:0000253) | 2.19688451 |
| 61 | CNS demyelination (HP:0007305) | 2.16141950 |
| 62 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.15442017 |
| 63 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.15442017 |
| 64 | Abnormal protein glycosylation (HP:0012346) | 2.15442017 |
| 65 | Abnormal glycosylation (HP:0012345) | 2.15442017 |
| 66 | Reduced antithrombin III activity (HP:0001976) | 2.14951833 |
| 67 | IgM deficiency (HP:0002850) | 2.09830692 |
| 68 | Colon cancer (HP:0003003) | 2.09340668 |
| 69 | Abnormality of T cell physiology (HP:0011840) | 2.08390896 |
| 70 | Neoplasm of the adrenal gland (HP:0100631) | 2.04622219 |
| 71 | Atrophy/Degeneration involving motor neurons (HP:0007373) | 2.04239095 |
| 72 | Abolished electroretinogram (ERG) (HP:0000550) | 2.01991657 |
| 73 | Lethargy (HP:0001254) | 2.01483632 |
| 74 | Mesangial abnormality (HP:0001966) | 1.96722291 |
| 75 | Hypergammaglobulinemia (HP:0010702) | 1.95796549 |
| 76 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 1.95235810 |
| 77 | Meningitis (HP:0001287) | 1.94995262 |
| 78 | Microvesicular hepatic steatosis (HP:0001414) | 1.94682435 |
| 79 | Aplasia/Hypoplasia of the thymus (HP:0010515) | 1.89752522 |
| 80 | Neutropenia (HP:0001875) | 1.87985740 |
| 81 | Abnormality of urine glucose concentration (HP:0011016) | 1.87526034 |
| 82 | Glycosuria (HP:0003076) | 1.87526034 |
| 83 | Abnormality of renal resorption (HP:0011038) | 1.85644678 |
| 84 | Hyperglycinemia (HP:0002154) | 1.85553310 |
| 85 | Stomatitis (HP:0010280) | 1.84727969 |
| 86 | Meckel diverticulum (HP:0002245) | 1.84007095 |
| 87 | Recurrent viral infections (HP:0004429) | 1.83588485 |
| 88 | Spastic paraparesis (HP:0002313) | 1.83122687 |
| 89 | Abnormal delayed hypersensitivity skin test (HP:0002963) | 1.83032710 |
| 90 | Abnormality of male internal genitalia (HP:0000022) | 1.81667724 |
| 91 | Type 2 muscle fiber atrophy (HP:0003554) | 1.80316707 |
| 92 | Hyperphosphaturia (HP:0003109) | 1.77106293 |
| 93 | Amniotic constriction ring (HP:0009775) | 1.74322564 |
| 94 | Abnormality of placental membranes (HP:0011409) | 1.74322564 |
| 95 | Leukocytosis (HP:0001974) | 1.73745129 |
| 96 | Hypoplasia of the thymus (HP:0000778) | 1.71163152 |
| 97 | Abnormality of the ileum (HP:0001549) | 1.70537376 |
| 98 | Pulmonary fibrosis (HP:0002206) | 1.69833275 |
| 99 | Muscle fiber atrophy (HP:0100295) | 1.68854603 |
| 100 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 1.66321222 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | VRK2 | 5.49577010 |
| 2 | KDR | 4.79084166 |
| 3 | TESK2 | 3.47261641 |
| 4 | NUAK1 | 2.97318443 |
| 5 | VRK1 | 2.76020415 |
| 6 | SCYL2 | 2.47704856 |
| 7 | TESK1 | 2.22907562 |
| 8 | BUB1 | 2.19455515 |
| 9 | TXK | 2.06860488 |
| 10 | MST4 | 2.06647518 |
| 11 | EIF2AK3 | 2.05052299 |
| 12 | MAP4K2 | 2.03211329 |
| 13 | BCKDK | 1.94781509 |
| 14 | NEK1 | 1.93252128 |
| 15 | MAP3K12 | 1.91869668 |
| 16 | WEE1 | 1.85226162 |
| 17 | SRPK1 | 1.77537913 |
| 18 | KIT | 1.74538912 |
| 19 | LIMK1 | 1.66674506 |
| 20 | ZAK | 1.65777160 |
| 21 | TIE1 | 1.50541726 |
| 22 | NME2 | 1.48978843 |
| 23 | STK16 | 1.46992337 |
| 24 | BMPR2 | 1.31457991 |
| 25 | PBK | 1.30807344 |
| 26 | CDC7 | 1.29902183 |
| 27 | TAOK3 | 1.27016192 |
| 28 | CDK8 | 1.17538092 |
| 29 | EIF2AK1 | 1.16182302 |
| 30 | TAF1 | 1.14468190 |
| 31 | FLT3 | 1.13258885 |
| 32 | TSSK6 | 1.10854258 |
| 33 | BMPR1B | 1.09123224 |
| 34 | ADRBK2 | 1.06478568 |
| 35 | DAPK1 | 1.06394949 |
| 36 | CCNB1 | 1.04196252 |
| 37 | MAP3K11 | 0.97820057 |
| 38 | MAPK15 | 0.95924392 |
| 39 | PLK4 | 0.92139609 |
| 40 | PLK3 | 0.88925196 |
| 41 | DYRK2 | 0.87708172 |
| 42 | EIF2AK2 | 0.87337755 |
| 43 | GRK1 | 0.87047818 |
| 44 | CSNK1G3 | 0.86897949 |
| 45 | STK39 | 0.86612440 |
| 46 | MAP4K1 | 0.85397340 |
| 47 | SYK | 0.83634504 |
| 48 | PNCK | 0.82298464 |
| 49 | PIM2 | 0.82175994 |
| 50 | ATR | 0.78949814 |
| 51 | TNK2 | 0.78021808 |
| 52 | FES | 0.76668671 |
| 53 | OXSR1 | 0.74019026 |
| 54 | PLK1 | 0.73291897 |
| 55 | PRKCQ | 0.73181253 |
| 56 | ABL2 | 0.72182130 |
| 57 | CHEK2 | 0.70825945 |
| 58 | RPS6KA4 | 0.70810221 |
| 59 | AURKB | 0.70493112 |
| 60 | BCR | 0.70397779 |
| 61 | MAPKAPK5 | 0.69749407 |
| 62 | INSRR | 0.69539763 |
| 63 | CSNK1G1 | 0.68957733 |
| 64 | ITK | 0.67129318 |
| 65 | CASK | 0.66075126 |
| 66 | CSF1R | 0.64585092 |
| 67 | AURKA | 0.64270496 |
| 68 | CSNK1A1L | 0.61559784 |
| 69 | TEC | 0.59946318 |
| 70 | LYN | 0.59226015 |
| 71 | MAPKAPK3 | 0.58086077 |
| 72 | CSNK1G2 | 0.56806451 |
| 73 | GRK7 | 0.55765228 |
| 74 | GRK5 | 0.55618894 |
| 75 | PLK2 | 0.55457674 |
| 76 | STK38L | 0.55414353 |
| 77 | CSNK2A1 | 0.54796497 |
| 78 | NME1 | 0.52935296 |
| 79 | WNK4 | 0.51935165 |
| 80 | MAPK13 | 0.50808622 |
| 81 | LCK | 0.49934314 |
| 82 | WNK3 | 0.49453761 |
| 83 | MYLK | 0.49226254 |
| 84 | BRSK2 | 0.48332614 |
| 85 | MATK | 0.48241754 |
| 86 | RPS6KA5 | 0.47016238 |
| 87 | IKBKB | 0.46237371 |
| 88 | TLK1 | 0.44888875 |
| 89 | CSNK2A2 | 0.43379380 |
| 90 | BLK | 0.42892521 |
| 91 | CDK9 | 0.42252709 |
| 92 | DYRK3 | 0.41089635 |
| 93 | PDK2 | 0.33897039 |
| 94 | TTK | 0.31745082 |
| 95 | DAPK3 | 0.30803009 |
| 96 | MAP2K7 | 0.30170078 |
| 97 | CSNK1A1 | 0.29819090 |
| 98 | LRRK2 | 0.28508014 |
| 99 | BTK | 0.28186118 |
| 100 | MAPKAPK2 | 0.27356735 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 5.29343965 |
| 2 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 3.46668842 |
| 3 | DNA replication_Homo sapiens_hsa03030 | 3.23757184 |
| 4 | Parkinsons disease_Homo sapiens_hsa05012 | 3.20773534 |
| 5 | Primary immunodeficiency_Homo sapiens_hsa05340 | 3.01476046 |
| 6 | Protein export_Homo sapiens_hsa03060 | 2.84973056 |
| 7 | Mismatch repair_Homo sapiens_hsa03430 | 2.60282228 |
| 8 | Homologous recombination_Homo sapiens_hsa03440 | 2.23638937 |
| 9 | Base excision repair_Homo sapiens_hsa03410 | 2.21065107 |
| 10 | RNA polymerase_Homo sapiens_hsa03020 | 2.17529136 |
| 11 | Graft-versus-host disease_Homo sapiens_hsa05332 | 2.12985599 |
| 12 | Asthma_Homo sapiens_hsa05310 | 2.05485746 |
| 13 | Allograft rejection_Homo sapiens_hsa05330 | 2.03434356 |
| 14 | Alzheimers disease_Homo sapiens_hsa05010 | 1.99703443 |
| 15 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 1.99236830 |
| 16 | Huntingtons disease_Homo sapiens_hsa05016 | 1.98117188 |
| 17 | Ribosome_Homo sapiens_hsa03010 | 1.90846432 |
| 18 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.89070685 |
| 19 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.83957005 |
| 20 | Antigen processing and presentation_Homo sapiens_hsa04612 | 1.82424334 |
| 21 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.80500673 |
| 22 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 1.76197921 |
| 23 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.74802894 |
| 24 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.71497451 |
| 25 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.69410770 |
| 26 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.66281114 |
| 27 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 1.54924644 |
| 28 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 1.45553779 |
| 29 | Spliceosome_Homo sapiens_hsa03040 | 1.42521357 |
| 30 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.38878585 |
| 31 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.32198144 |
| 32 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.31288401 |
| 33 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.26133857 |
| 34 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 1.22460656 |
| 35 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 1.18607946 |
| 36 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.16426280 |
| 37 | RNA degradation_Homo sapiens_hsa03018 | 1.14486772 |
| 38 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.10876654 |
| 39 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 1.04676336 |
| 40 | Purine metabolism_Homo sapiens_hsa00230 | 1.02950031 |
| 41 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.01135531 |
| 42 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.99448094 |
| 43 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.96320075 |
| 44 | Peroxisome_Homo sapiens_hsa04146 | 0.91730445 |
| 45 | Viral myocarditis_Homo sapiens_hsa05416 | 0.88611806 |
| 46 | RNA transport_Homo sapiens_hsa03013 | 0.88319281 |
| 47 | Basal transcription factors_Homo sapiens_hsa03022 | 0.84181749 |
| 48 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.80673433 |
| 49 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.79440085 |
| 50 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.75361382 |
| 51 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.73089190 |
| 52 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.72807943 |
| 53 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.72227029 |
| 54 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.72061371 |
| 55 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.70679140 |
| 56 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.69643774 |
| 57 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.61543439 |
| 58 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 0.61143516 |
| 59 | Sulfur relay system_Homo sapiens_hsa04122 | 0.60859647 |
| 60 | Carbon metabolism_Homo sapiens_hsa01200 | 0.60433861 |
| 61 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.60421281 |
| 62 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.59373025 |
| 63 | Metabolic pathways_Homo sapiens_hsa01100 | 0.58019198 |
| 64 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.57992362 |
| 65 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.57990608 |
| 66 | Shigellosis_Homo sapiens_hsa05131 | 0.57930855 |
| 67 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.57799415 |
| 68 | Salmonella infection_Homo sapiens_hsa05132 | 0.55713922 |
| 69 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.53214134 |
| 70 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.49927060 |
| 71 | Cell cycle_Homo sapiens_hsa04110 | 0.47724722 |
| 72 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 0.47186311 |
| 73 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.46724387 |
| 74 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.42868456 |
| 75 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.41871329 |
| 76 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.40934810 |
| 77 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 0.40522635 |
| 78 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.38590006 |
| 79 | Phototransduction_Homo sapiens_hsa04744 | 0.38061675 |
| 80 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.36372140 |
| 81 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.36175650 |
| 82 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.34496533 |
| 83 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.33936777 |
| 84 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.33438590 |
| 85 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.31505024 |
| 86 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.30921340 |
| 87 | Olfactory transduction_Homo sapiens_hsa04740 | 0.30863112 |
| 88 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.29246258 |
| 89 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.26340345 |
| 90 | Measles_Homo sapiens_hsa05162 | 0.26183180 |
| 91 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.26165585 |
| 92 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.25781150 |
| 93 | Leishmaniasis_Homo sapiens_hsa05140 | 0.25448703 |
| 94 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.25169248 |
| 95 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.24298263 |
| 96 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.24166577 |
| 97 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.23947448 |
| 98 | Retinol metabolism_Homo sapiens_hsa00830 | 0.21926344 |
| 99 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.20074699 |
| 100 | Legionellosis_Homo sapiens_hsa05134 | 0.19072752 |

