FABP5P10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)7.57602993
2maturation of 5.8S rRNA (GO:0000460)5.29104692
3regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.97365776
4cytidine metabolic process (GO:0046087)4.85350693
5cytidine catabolic process (GO:0006216)4.85350693
6cytidine deamination (GO:0009972)4.85350693
7RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.55499508
8tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.55499508
9DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:004.50777506
10proteasome assembly (GO:0043248)4.44862554
11negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.44735401
12intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)4.41329704
13signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)4.41329704
14signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)4.41156020
15signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)4.41156020
16signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)4.41156020
17regulation of cellular amino acid metabolic process (GO:0006521)4.40222638
18GTP biosynthetic process (GO:0006183)4.31532512
19maturation of SSU-rRNA (GO:0030490)4.30175943
20somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)4.24815399
21somatic diversification of immunoglobulins involved in immune response (GO:0002208)4.24815399
22isotype switching (GO:0045190)4.24815399
23positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.24271691
24energy coupled proton transport, down electrochemical gradient (GO:0015985)4.23667744
25ATP synthesis coupled proton transport (GO:0015986)4.23667744
26signal transduction involved in DNA damage checkpoint (GO:0072422)4.23256772
27signal transduction involved in DNA integrity checkpoint (GO:0072401)4.23256772
28mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.18895318
29signal transduction involved in cell cycle checkpoint (GO:0072395)4.17091031
30pyrimidine ribonucleoside catabolic process (GO:0046133)4.04285119
31nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.98113703
32regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.96336146
33negative regulation of ligase activity (GO:0051352)3.95908779
34negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.95908779
35cellular response to ATP (GO:0071318)3.94837662
36chaperone-mediated protein transport (GO:0072321)3.94559544
37UTP biosynthetic process (GO:0006228)3.83076496
38anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.82948146
39mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.80092601
40mitochondrial respiratory chain complex I assembly (GO:0032981)3.80092601
41NADH dehydrogenase complex assembly (GO:0010257)3.80092601
42protein complex biogenesis (GO:0070271)3.77014158
43antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.67286776
44ribosomal large subunit biogenesis (GO:0042273)3.66832777
45exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.65300872
46mitochondrial respiratory chain complex assembly (GO:0033108)3.57567452
47establishment of protein localization to mitochondrial membrane (GO:0090151)3.56226842
48positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.55133975
49protein K63-linked deubiquitination (GO:0070536)3.50707422
50positive regulation of ligase activity (GO:0051351)3.45330764
51UTP metabolic process (GO:0046051)3.44244819
52positive regulation of cell cycle arrest (GO:0071158)3.44197140
53viral mRNA export from host cell nucleus (GO:0046784)3.43612583
54antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.43407887
55glomerular visceral epithelial cell development (GO:0072015)3.42758135
56electron transport chain (GO:0022900)3.40508569
57DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.40061186
58respiratory electron transport chain (GO:0022904)3.37641009
59histone mRNA metabolic process (GO:0008334)3.37132949
60mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.34188549
61RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.32134572
62rRNA modification (GO:0000154)3.30421469
63protein neddylation (GO:0045116)3.24804138
64guanosine-containing compound biosynthetic process (GO:1901070)3.23979758
65dolichol-linked oligosaccharide biosynthetic process (GO:0006488)3.23689072
66GDP-mannose metabolic process (GO:0019673)3.23570664
67rRNA methylation (GO:0031167)3.22003938
68rRNA processing (GO:0006364)3.17858680
69regulation of cellular amine metabolic process (GO:0033238)3.17787949
70pseudouridine synthesis (GO:0001522)3.13772862
71rRNA metabolic process (GO:0016072)3.06390869
72water-soluble vitamin biosynthetic process (GO:0042364)3.03370573
73ncRNA catabolic process (GO:0034661)3.01637027
74CTP metabolic process (GO:0046036)3.00893142
75CTP biosynthetic process (GO:0006241)3.00893142
76glomerular epithelial cell development (GO:0072310)2.97017246
77regulation of ubiquitin-protein transferase activity (GO:0051438)2.95818004
78DNA replication checkpoint (GO:0000076)2.93361954
79DNA double-strand break processing (GO:0000729)2.92779102
80transcription elongation from RNA polymerase I promoter (GO:0006362)2.91260128
81regulation of ligase activity (GO:0051340)2.90252468
82signal peptide processing (GO:0006465)2.90022034
83somatic recombination of immunoglobulin gene segments (GO:0016447)2.89761848
84sequestering of metal ion (GO:0051238)2.87179296
85purine nucleoside triphosphate biosynthetic process (GO:0009145)2.85049491
86regulation of immunoglobulin secretion (GO:0051023)2.84004554
87antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.83298206
88IMP biosynthetic process (GO:0006188)2.81974740
89negative regulation of protein ubiquitination (GO:0031397)2.81273910
90regulation of mitotic spindle checkpoint (GO:1903504)2.79735262
91regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.79735262
92termination of RNA polymerase III transcription (GO:0006386)2.79422926
93transcription elongation from RNA polymerase III promoter (GO:0006385)2.79422926
94negative regulation of G1/S transition of mitotic cell cycle (GO:2000134)2.79411699
95negative regulation of cell cycle G1/S phase transition (GO:1902807)2.79411699
96purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.77326123
97RNA phosphodiester bond hydrolysis (GO:0090501)2.76952605
98signal transduction in response to DNA damage (GO:0042770)2.76304353
99regulation of cell cycle arrest (GO:0071156)2.76266609
100aldehyde catabolic process (GO:0046185)2.75688628

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.28041145
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.00425970
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.61113565
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.90044808
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.57813477
6VDR_22108803_ChIP-Seq_LS180_Human3.43599324
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.32767840
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.03402230
9ELF1_17652178_ChIP-ChIP_JURKAT_Human2.82543482
10HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.79005010
11E2F4_17652178_ChIP-ChIP_JURKAT_Human2.63060864
12ELK1_19687146_ChIP-ChIP_HELA_Human2.48709660
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.47896363
14VDR_23849224_ChIP-Seq_CD4+_Human2.46831667
15MYC_18555785_ChIP-Seq_MESCs_Mouse2.44775918
16BP1_19119308_ChIP-ChIP_Hs578T_Human2.36670067
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.35360655
18FLI1_27457419_Chip-Seq_LIVER_Mouse2.26439545
19SRF_21415370_ChIP-Seq_HL-1_Mouse2.19476617
20SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.17577049
21FOXP3_21729870_ChIP-Seq_TREG_Human2.12057626
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.11797426
23NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.00144262
24PCGF2_27294783_Chip-Seq_ESCs_Mouse1.93010373
25EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.91287509
26MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.86323746
27PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.82908489
28YY1_21170310_ChIP-Seq_MESCs_Mouse1.77094330
29MYC_18358816_ChIP-ChIP_MESCs_Mouse1.75780939
30IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.72140159
31PCGF2_27294783_Chip-Seq_NPCs_Mouse1.68648847
32FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.65639501
33TP53_22573176_ChIP-Seq_HFKS_Human1.63175969
34MYC_19030024_ChIP-ChIP_MESCs_Mouse1.60794373
35PADI4_21655091_ChIP-ChIP_MCF-7_Human1.58293790
36DCP1A_22483619_ChIP-Seq_HELA_Human1.57519999
37PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.53341134
38CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.51879487
39PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.50715178
40CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.50597954
41GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.47838905
42MYC_18940864_ChIP-ChIP_HL60_Human1.47244404
43POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.44851432
44HOXB4_20404135_ChIP-ChIP_EML_Mouse1.41673412
45IRF8_22096565_ChIP-ChIP_GC-B_Human1.41003670
46IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.39650484
47ZNF274_21170338_ChIP-Seq_K562_Hela1.39125832
48FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.38886693
49GABP_19822575_ChIP-Seq_HepG2_Human1.37021222
50EWS_26573619_Chip-Seq_HEK293_Human1.36030589
51EGR1_23403033_ChIP-Seq_LIVER_Mouse1.34465356
52FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.32345501
53ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.31633196
54ELK1_22589737_ChIP-Seq_MCF10A_Human1.30194094
55SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.27337425
56E2F1_18555785_ChIP-Seq_MESCs_Mouse1.26751265
57MYC_19079543_ChIP-ChIP_MESCs_Mouse1.26544821
58NFE2_27457419_Chip-Seq_LIVER_Mouse1.20993693
59IRF8_21731497_ChIP-ChIP_J774_Mouse1.17711562
60SUZ12_27294783_Chip-Seq_NPCs_Mouse1.16132120
61TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15162667
62EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.12897467
63TTF2_22483619_ChIP-Seq_HELA_Human1.11995548
64EZH2_27294783_Chip-Seq_NPCs_Mouse1.07715327
65GATA3_26560356_Chip-Seq_TH2_Human1.04029477
66HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.02899013
67THAP11_20581084_ChIP-Seq_MESCs_Mouse1.02094666
68SALL4_22934838_ChIP-ChIP_CD34+_Human1.00467274
69EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.00207954
70MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.98824708
71SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.98440310
72ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.98327848
73CRX_20693478_ChIP-Seq_RETINA_Mouse0.98279138
74NANOG_19829295_ChIP-Seq_ESCs_Human0.94916840
75SOX2_19829295_ChIP-Seq_ESCs_Human0.94916840
76FOXA1_27270436_Chip-Seq_PROSTATE_Human0.94259308
77FOXA1_25329375_ChIP-Seq_VCAP_Human0.94259308
78NELFA_20434984_ChIP-Seq_ESCs_Mouse0.94014711
79P300_19829295_ChIP-Seq_ESCs_Human0.93757088
80E2F7_22180533_ChIP-Seq_HELA_Human0.93139545
81CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.92376462
82HTT_18923047_ChIP-ChIP_STHdh_Human0.91974704
83SOX2_18555785_Chip-Seq_ESCs_Mouse0.91623748
84LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.91201867
85ERG_20517297_ChIP-Seq_VCAP_Human0.90964871
86STAT3_18555785_Chip-Seq_ESCs_Mouse0.87169324
87XRN2_22483619_ChIP-Seq_HELA_Human0.86811313
88CTBP1_25329375_ChIP-Seq_LNCAP_Human0.86074662
89BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.84929299
90TAF2_19829295_ChIP-Seq_ESCs_Human0.84831780
91HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.84203318
92HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.84034470
93P300_18555785_Chip-Seq_ESCs_Mouse0.83949396
94AR_20517297_ChIP-Seq_VCAP_Human0.83715560
95SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.83654594
96STAT4_19710469_ChIP-ChIP_TH1__Mouse0.82574123
97AUTS2_25519132_ChIP-Seq_293T-REX_Human0.82406474
98GATA3_21878914_ChIP-Seq_MCF-7_Human0.81793935
99POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.81132038
100PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.80180594

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.09245275
2MP0005671_abnormal_response_to3.99959754
3MP0008875_abnormal_xenobiotic_pharmacok3.96480980
4MP0002102_abnormal_ear_morphology3.44941776
5MP0003806_abnormal_nucleotide_metabolis3.30806080
6MP0003693_abnormal_embryo_hatching3.18029267
7MP0003195_calcinosis2.94546486
8MP0000685_abnormal_immune_system2.78095855
9MP0001873_stomach_inflammation2.75029157
10MP0005408_hypopigmentation2.55826741
11MP0008058_abnormal_DNA_repair2.55300797
12MP0002736_abnormal_nociception_after2.43345378
13MP0005360_urolithiasis2.37931262
14MP0003950_abnormal_plasma_membrane2.15216385
15MP0001968_abnormal_touch/_nociception2.14053602
16MP0004145_abnormal_muscle_electrophysio2.13612187
17MP0009785_altered_susceptibility_to2.08505154
18MP0008872_abnormal_physiological_respon2.06352084
19MP0009333_abnormal_splenocyte_physiolog2.04382444
20MP0005387_immune_system_phenotype2.03412531
21MP0001790_abnormal_immune_system2.03412531
22MP0004957_abnormal_blastocyst_morpholog2.03096095
23MP0003890_abnormal_embryonic-extraembry1.91103099
24MP0005084_abnormal_gallbladder_morpholo1.84187190
25MP0004147_increased_porphyrin_level1.81345378
26MP0001529_abnormal_vocalization1.78498453
27MP0005167_abnormal_blood-brain_barrier1.77015710
28MP0010094_abnormal_chromosome_stability1.73229392
29MP0003045_fibrosis1.67480895
30MP0001800_abnormal_humoral_immune1.59813015
31MP0005645_abnormal_hypothalamus_physiol1.51517494
32MP0002166_altered_tumor_susceptibility1.51389305
33MP0004142_abnormal_muscle_tone1.50276598
34MP0003786_premature_aging1.46089245
35MP0006036_abnormal_mitochondrial_physio1.44051829
36MP0002148_abnormal_hypersensitivity_rea1.34869984
37MP0008007_abnormal_cellular_replicative1.31973340
38MP0005000_abnormal_immune_tolerance1.31806603
39MP0003186_abnormal_redox_activity1.26781648
40MP0004885_abnormal_endolymph1.24275382
41MP0004782_abnormal_surfactant_physiolog1.24073913
42MP0003011_delayed_dark_adaptation1.18880507
43MP0008877_abnormal_DNA_methylation1.18073847
44MP0002405_respiratory_system_inflammati1.17476310
45MP0002006_tumorigenesis1.15285498
46MP0005551_abnormal_eye_electrophysiolog1.15139151
47MP0003718_maternal_effect1.14990252
48MP0002138_abnormal_hepatobiliary_system1.12692218
49MP0000749_muscle_degeneration1.11893820
50MP0005636_abnormal_mineral_homeostasis1.11755378
51MP0010155_abnormal_intestine_physiology1.09533447
52MP0001919_abnormal_reproductive_system1.08309140
53MP0002452_abnormal_antigen_presenting1.04365923
54MP0000372_irregular_coat_pigmentation0.98751498
55MP0001905_abnormal_dopamine_level0.97208414
56MP0005389_reproductive_system_phenotype0.96926288
57MP0001764_abnormal_homeostasis0.96799266
58MP0003866_abnormal_defecation0.95313514
59MP0003567_abnormal_fetal_cardiomyocyte0.94606440
60MP0006035_abnormal_mitochondrial_morpho0.94211469
61MP0006072_abnormal_retinal_apoptosis0.92931284
62MP0003763_abnormal_thymus_physiology0.92455949
63MP0002723_abnormal_immune_serum0.92335898
64MP0005025_abnormal_response_to0.91069589
65MP0005085_abnormal_gallbladder_physiolo0.89566788
66MP0002909_abnormal_adrenal_gland0.89438073
67MP0001958_emphysema0.89412482
68MP0008873_increased_physiological_sensi0.87280268
69MP0003137_abnormal_impulse_conducting0.86426317
70MP0005584_abnormal_enzyme/coenzyme_acti0.85746864
71MP0002693_abnormal_pancreas_physiology0.84387773
72MP0005365_abnormal_bile_salt0.83902948
73MP0002420_abnormal_adaptive_immunity0.83588820
74MP0005379_endocrine/exocrine_gland_phen0.82531891
75MP0001845_abnormal_inflammatory_respons0.82097083
76MP0001819_abnormal_immune_cell0.81309546
77MP0005319_abnormal_enzyme/_coenzyme0.79795610
78MP0000470_abnormal_stomach_morphology0.79593420
79MP0009745_abnormal_behavioral_response0.79110126
80MP0000358_abnormal_cell_content/0.78808882
81MP0000689_abnormal_spleen_morphology0.78691784
82MP0005075_abnormal_melanosome_morpholog0.76687817
83MP0005076_abnormal_cell_differentiation0.76045598
84MP0005332_abnormal_amino_acid0.75870726
85MP0001485_abnormal_pinna_reflex0.74249194
86MP0003111_abnormal_nucleus_morphology0.69855380
87MP0003646_muscle_fatigue0.68655843
88MP0003252_abnormal_bile_duct0.68095674
89MP0002938_white_spotting0.67275395
90MP0004742_abnormal_vestibular_system0.64369343
91MP0002733_abnormal_thermal_nociception0.64308398
92MP0003943_abnormal_hepatobiliary_system0.63359901
93MP0002139_abnormal_hepatobiliary_system0.63191917
94MP0001663_abnormal_digestive_system0.63099857
95MP0004019_abnormal_vitamin_homeostasis0.62602263
96MP0002396_abnormal_hematopoietic_system0.62558291
97MP0001970_abnormal_pain_threshold0.60168733
98MP0003638_abnormal_response/metabolism_0.58449033
99MP0003077_abnormal_cell_cycle0.57560809
100MP0000716_abnormal_immune_system0.57536228

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)6.10564565
2Hypoproteinemia (HP:0003075)5.56513389
3Abnormality of the pons (HP:0007361)4.92749686
4Reduced antithrombin III activity (HP:0001976)4.89628260
5Hypoplasia of the pons (HP:0012110)4.38811377
6Type I transferrin isoform profile (HP:0003642)4.21899728
7Acute necrotizing encephalopathy (HP:0006965)4.16045087
8Abnormal mitochondria in muscle tissue (HP:0008316)3.92647144
9Mitochondrial inheritance (HP:0001427)3.78627119
10Abnormality of DNA repair (HP:0003254)3.70651947
11Increased CSF lactate (HP:0002490)3.60080323
12Hepatocellular necrosis (HP:0001404)3.50186977
13Hepatic necrosis (HP:0002605)3.47588678
14Acute encephalopathy (HP:0006846)3.45922458
15Progressive macrocephaly (HP:0004481)3.33444303
16Increased IgM level (HP:0003496)3.31452927
17Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.29589912
18Decreased activity of mitochondrial respiratory chain (HP:0008972)3.29589912
19Increased serum pyruvate (HP:0003542)3.24075190
20Duplicated collecting system (HP:0000081)3.21854290
21Type 2 muscle fiber atrophy (HP:0003554)3.20867909
22IgG deficiency (HP:0004315)3.16428939
23Cerebral hypomyelination (HP:0006808)3.12194070
24Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.02341563
25Abnormal protein N-linked glycosylation (HP:0012347)3.02341563
26Abnormal protein glycosylation (HP:0012346)3.02341563
27Abnormal glycosylation (HP:0012345)3.02341563
28CNS demyelination (HP:0007305)2.98474484
29Amniotic constriction ring (HP:0009775)2.84305729
30Abnormality of placental membranes (HP:0011409)2.84305729
31Abnormality of the renal collecting system (HP:0004742)2.83129093
32Increased serum lactate (HP:0002151)2.74644552
33Abnormality of glycolysis (HP:0004366)2.69316168
34Muscle fiber atrophy (HP:0100295)2.65812545
35Methylmalonic acidemia (HP:0002912)2.64926439
36Oral leukoplakia (HP:0002745)2.64334585
37Increased hepatocellular lipid droplets (HP:0006565)2.62287667
38Abnormality of aspartate family amino acid metabolism (HP:0010899)2.59805112
39Exercise intolerance (HP:0003546)2.56095192
40Lipid accumulation in hepatocytes (HP:0006561)2.53661886
41Methylmalonic aciduria (HP:0012120)2.51450775
42Abnormality of methionine metabolism (HP:0010901)2.50716495
43Poor head control (HP:0002421)2.50602104
44Cerebral edema (HP:0002181)2.49306811
45Abnormality of T cell physiology (HP:0011840)2.45067733
46Abnormality of the ileum (HP:0001549)2.37408304
47Panhypogammaglobulinemia (HP:0003139)2.36916296
48Optic disc pallor (HP:0000543)2.34202790
49Respiratory failure (HP:0002878)2.32858353
50Hypochromic microcytic anemia (HP:0004840)2.30137884
51Dynein arm defect of respiratory motile cilia (HP:0012255)2.29932590
52Absent/shortened dynein arms (HP:0200106)2.29932590
53IgA deficiency (HP:0002720)2.25229888
54Absent thumb (HP:0009777)2.24524521
55Large for gestational age (HP:0001520)2.24319985
56Lactic acidosis (HP:0003128)2.22155747
57Abnormality of the labia minora (HP:0012880)2.20454392
58Increased intramyocellular lipid droplets (HP:0012240)2.19419147
59Cleft eyelid (HP:0000625)2.16812974
60Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.16703826
61Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.15280978
62Multiple enchondromatosis (HP:0005701)2.10082306
63Pancreatic islet-cell hyperplasia (HP:0004510)2.09672006
64Lethargy (HP:0001254)2.09102949
65Prolonged QT interval (HP:0001657)2.08751960
66Abnormality of the prostate (HP:0008775)2.06909623
67Oligomenorrhea (HP:0000876)2.06611539
68Abnormality of the renal cortex (HP:0011035)2.04802576
69Renal cortical cysts (HP:0000803)2.04463187
70Leukodystrophy (HP:0002415)2.01256198
71Exertional dyspnea (HP:0002875)2.00694012
72Meckel diverticulum (HP:0002245)1.99000766
73Opisthotonus (HP:0002179)1.96317379
743-Methylglutaconic aciduria (HP:0003535)1.92390438
75Clubbing of toes (HP:0100760)1.91196831
76Aplasia/Hypoplasia of the uvula (HP:0010293)1.90923795
77Renal Fanconi syndrome (HP:0001994)1.90551006
78Abnormality of the preputium (HP:0100587)1.89908110
79Degeneration of anterior horn cells (HP:0002398)1.87128193
80Abnormality of the anterior horn cell (HP:0006802)1.87128193
81Generalized aminoaciduria (HP:0002909)1.85579934
82Abnormality of T cells (HP:0002843)1.85378634
83Microvesicular hepatic steatosis (HP:0001414)1.84469488
84Inability to walk (HP:0002540)1.83124597
85Increased muscle lipid content (HP:0009058)1.80783226
86Aplasia/Hypoplasia involving the musculature (HP:0001460)1.77694201
87Myopathic facies (HP:0002058)1.77518841
88Respiratory difficulties (HP:0002880)1.69380973
89Dicarboxylic aciduria (HP:0003215)1.69136058
90Abnormality of dicarboxylic acid metabolism (HP:0010995)1.69136058
91Supernumerary spleens (HP:0009799)1.68535584
92Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.67746078
93Abnormality of alanine metabolism (HP:0010916)1.67746078
94Hyperalaninemia (HP:0003348)1.67746078
95Abnormal respiratory epithelium morphology (HP:0012253)1.67457548
96Abnormal respiratory motile cilium morphology (HP:0005938)1.67457548
97Abnormality of homocysteine metabolism (HP:0010919)1.65828206
98Homocystinuria (HP:0002156)1.65828206
99Megaloblastic anemia (HP:0001889)1.65767203
100Cerebral hemorrhage (HP:0001342)1.63826336

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.11726346
2EIF2AK34.03935025
3TLK13.37850644
4MST43.32494613
5NUAK13.23018718
6BUB13.20425713
7ZAK3.05378069
8VRK12.76341235
9TSSK62.55579261
10EIF2AK12.48366118
11NME12.36969009
12TXK2.36569064
13TAF12.21034547
14MAP3K122.13634365
15ADRBK21.90249882
16NEK11.90099538
17PLK31.83685715
18PBK1.82358003
19SMG11.81052875
20IKBKE1.46741914
21NEK91.44762516
22GRK11.41670151
23DAPK11.36346219
24WNK31.27359551
25PDK21.27172476
26CCNB11.24577157
27EIF2AK21.20801753
28SCYL21.19525139
29PLK41.18083160
30TRIM281.15801020
31OXSR11.13177655
32IKBKB1.09337430
33DYRK21.08029521
34CSNK1G31.06746813
35PLK21.06553051
36WEE11.05092431
37CSNK1A1L1.03072482
38MYLK1.01940973
39NME20.97386581
40FRK0.97201364
41CAMKK20.96099016
42OBSCN0.93188258
43ATR0.91941687
44BCKDK0.88052535
45BMPR1B0.86066799
46DAPK20.84015626
47CSNK1G10.83203660
48PAK40.83177385
49CSNK1G20.83156603
50DAPK30.82954184
51SYK0.79481475
52STK160.77454104
53PLK10.76119657
54FGFR10.75825258
55PRKCQ0.73933115
56JAK30.72593380
57TAOK30.71406925
58SRPK10.68537646
59STK390.64090643
60CDC70.61499688
61AURKB0.60362597
62INSRR0.60201303
63RIPK40.60075057
64WNK40.59069086
65PHKG20.58971554
66PHKG10.58971554
67TTK0.56364322
68AURKA0.56170845
69STK100.55018559
70STK40.54519476
71PNCK0.53119525
72LATS10.49810946
73PRKCE0.47322773
74TIE10.46028098
75ADRBK10.45592838
76IGF1R0.45457208
77CHEK20.45416652
78RPS6KA50.44486848
79ATM0.44324579
80MAPKAPK50.43425708
81GRK50.41194442
82MKNK20.41159132
83LYN0.41036079
84CSNK2A20.39735405
85ITK0.39540788
86PRKCG0.38058142
87CSNK1E0.37256382
88PRKDC0.36827868
89PRKCA0.35460024
90CSNK1A10.34531216
91ALK0.33648011
92GRK70.32228073
93MAP3K140.31012589
94LCK0.29830285
95PRKCD0.29623233
96CSNK2A10.29003940
97PRKACA0.28244515
98PINK10.27168528
99MINK10.25465804
100CHEK10.25191708

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.57660890
2Oxidative phosphorylation_Homo sapiens_hsa001903.13125318
3Protein export_Homo sapiens_hsa030602.84251954
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.73665223
5Asthma_Homo sapiens_hsa053102.67184295
6Allograft rejection_Homo sapiens_hsa053302.47975453
7Parkinsons disease_Homo sapiens_hsa050122.45974499
8Vitamin B6 metabolism_Homo sapiens_hsa007502.31849749
9Autoimmune thyroid disease_Homo sapiens_hsa053202.16857937
10Intestinal immune network for IgA production_Homo sapiens_hsa046722.10583131
11Type I diabetes mellitus_Homo sapiens_hsa049401.92628227
12Primary immunodeficiency_Homo sapiens_hsa053401.85909319
13Rheumatoid arthritis_Homo sapiens_hsa053231.79347850
14RNA polymerase_Homo sapiens_hsa030201.74882541
15Ribosome_Homo sapiens_hsa030101.74443053
16Graft-versus-host disease_Homo sapiens_hsa053321.72187780
17RNA transport_Homo sapiens_hsa030131.71635405
18Systemic lupus erythematosus_Homo sapiens_hsa053221.71007223
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.66218284
20Mismatch repair_Homo sapiens_hsa034301.62699487
21RNA degradation_Homo sapiens_hsa030181.60996823
22Alzheimers disease_Homo sapiens_hsa050101.58761202
23Huntingtons disease_Homo sapiens_hsa050161.56195272
24DNA replication_Homo sapiens_hsa030301.54970519
25Nucleotide excision repair_Homo sapiens_hsa034201.54592997
26Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.50172599
27One carbon pool by folate_Homo sapiens_hsa006701.45667122
28Homologous recombination_Homo sapiens_hsa034401.42863552
29Pyruvate metabolism_Homo sapiens_hsa006201.41327193
30Fanconi anemia pathway_Homo sapiens_hsa034601.34760159
31Propanoate metabolism_Homo sapiens_hsa006401.32424713
32Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.28074943
33Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.23412676
34Cardiac muscle contraction_Homo sapiens_hsa042601.12015065
35Antigen processing and presentation_Homo sapiens_hsa046121.07210288
36Basal transcription factors_Homo sapiens_hsa030221.04003766
37N-Glycan biosynthesis_Homo sapiens_hsa005101.03903386
38Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.03682255
39Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.03544633
40Viral myocarditis_Homo sapiens_hsa054161.03417432
41Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.03259802
42Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.03134455
43Tryptophan metabolism_Homo sapiens_hsa003801.02765890
44Sulfur metabolism_Homo sapiens_hsa009201.01984948
452-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.01585117
46Pyrimidine metabolism_Homo sapiens_hsa002401.01177122
47Collecting duct acid secretion_Homo sapiens_hsa049660.96005877
48Spliceosome_Homo sapiens_hsa030400.94864505
49Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.91189122
50Nitrogen metabolism_Homo sapiens_hsa009100.90066379
51Non-homologous end-joining_Homo sapiens_hsa034500.88344431
52Base excision repair_Homo sapiens_hsa034100.87889524
53beta-Alanine metabolism_Homo sapiens_hsa004100.82792129
54Peroxisome_Homo sapiens_hsa041460.79369083
55Purine metabolism_Homo sapiens_hsa002300.79349283
56Fatty acid degradation_Homo sapiens_hsa000710.78503498
57Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.78439084
58Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.75594415
59Histidine metabolism_Homo sapiens_hsa003400.73357964
60Pentose and glucuronate interconversions_Homo sapiens_hsa000400.73184725
61Butanoate metabolism_Homo sapiens_hsa006500.72169455
62alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.69149845
63Linoleic acid metabolism_Homo sapiens_hsa005910.69028134
64Caffeine metabolism_Homo sapiens_hsa002320.62957057
65Fatty acid elongation_Homo sapiens_hsa000620.62238676
66Regulation of autophagy_Homo sapiens_hsa041400.61230406
67mRNA surveillance pathway_Homo sapiens_hsa030150.61104122
68Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.58577337
69Vitamin digestion and absorption_Homo sapiens_hsa049770.57590157
70Steroid biosynthesis_Homo sapiens_hsa001000.55906724
71Carbon metabolism_Homo sapiens_hsa012000.55100896
72Cyanoamino acid metabolism_Homo sapiens_hsa004600.54608883
73Metabolic pathways_Homo sapiens_hsa011000.53915261
74Selenocompound metabolism_Homo sapiens_hsa004500.53814380
75Cysteine and methionine metabolism_Homo sapiens_hsa002700.51471020
76Folate biosynthesis_Homo sapiens_hsa007900.49914620
77Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.49329588
78Epstein-Barr virus infection_Homo sapiens_hsa051690.46964954
79Arginine biosynthesis_Homo sapiens_hsa002200.45109853
80Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.44336911
81Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.44150741
82Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.41362460
83NF-kappa B signaling pathway_Homo sapiens_hsa040640.40679506
84NOD-like receptor signaling pathway_Homo sapiens_hsa046210.40103791
85Vibrio cholerae infection_Homo sapiens_hsa051100.37735762
86T cell receptor signaling pathway_Homo sapiens_hsa046600.37576899
87Hematopoietic cell lineage_Homo sapiens_hsa046400.36763682
88Sulfur relay system_Homo sapiens_hsa041220.36068301
89Glycerolipid metabolism_Homo sapiens_hsa005610.35408950
90Drug metabolism - other enzymes_Homo sapiens_hsa009830.34233690
91Phototransduction_Homo sapiens_hsa047440.34009148
92Alcoholism_Homo sapiens_hsa050340.32150166
93Ether lipid metabolism_Homo sapiens_hsa005650.31184899
94Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.30101398
95Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.30076127
96Fatty acid metabolism_Homo sapiens_hsa012120.29871877
97Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.27755025
98Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.27231368
99Glutathione metabolism_Homo sapiens_hsa004800.26234965
100Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.26089197

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