FABP5P11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of somitogenesis (GO:0014807)5.72686781
2ribosomal large subunit biogenesis (GO:0042273)5.37199078
3maturation of 5.8S rRNA (GO:0000460)5.15508970
4negative regulation of telomere maintenance (GO:0032205)5.10459058
5ribosomal small subunit biogenesis (GO:0042274)5.07770808
6negative regulation of telomerase activity (GO:0051974)5.04696456
7ATP synthesis coupled proton transport (GO:0015986)4.93903668
8energy coupled proton transport, down electrochemical gradient (GO:0015985)4.93903668
9mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.62274507
10mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.55694896
11establishment of protein localization to mitochondrial membrane (GO:0090151)4.52099948
12protein-cofactor linkage (GO:0018065)4.51734375
13DNA deamination (GO:0045006)4.47727753
14mitochondrial respiratory chain complex I assembly (GO:0032981)4.46425088
15NADH dehydrogenase complex assembly (GO:0010257)4.46425088
16mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.46425088
17viral transcription (GO:0019083)4.37384370
18respiratory electron transport chain (GO:0022904)4.32812450
19behavioral response to nicotine (GO:0035095)4.32775215
20electron transport chain (GO:0022900)4.30935922
21maturation of SSU-rRNA (GO:0030490)4.29200128
22translational termination (GO:0006415)4.12995361
23mitochondrial respiratory chain complex assembly (GO:0033108)4.01910616
24chaperone-mediated protein transport (GO:0072321)3.97662636
25protein complex biogenesis (GO:0070271)3.95109896
26regulation of telomerase activity (GO:0051972)3.77870553
27translational elongation (GO:0006414)3.71067975
28water-soluble vitamin biosynthetic process (GO:0042364)3.67822502
29GTP biosynthetic process (GO:0006183)3.58094921
30regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.57970384
31cotranslational protein targeting to membrane (GO:0006613)3.54148231
32regulation of telomere maintenance via telomerase (GO:0032210)3.53783745
33ribonucleoprotein complex biogenesis (GO:0022613)3.51232601
34DNA damage induced protein phosphorylation (GO:0006975)3.50861821
35SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.49523568
36protein targeting to ER (GO:0045047)3.48998455
37cellular component biogenesis (GO:0044085)3.47939260
38DNA damage response, detection of DNA damage (GO:0042769)3.46815067
39ribosomal small subunit assembly (GO:0000028)3.45526584
40protein neddylation (GO:0045116)3.45301393
41telomere maintenance via telomerase (GO:0007004)3.44725862
42negative regulation of DNA biosynthetic process (GO:2000279)3.42615029
43cell-cell junction maintenance (GO:0045217)3.35827881
44establishment of protein localization to endoplasmic reticulum (GO:0072599)3.30615731
45CTP biosynthetic process (GO:0006241)3.25631424
46CTP metabolic process (GO:0046036)3.25631424
47artery development (GO:0060840)3.23717685
48hydrogen ion transmembrane transport (GO:1902600)3.23404629
49cellular protein complex disassembly (GO:0043624)3.22471829
50protein localization to endoplasmic reticulum (GO:0070972)3.18231904
51viral life cycle (GO:0019058)3.16372062
52rRNA modification (GO:0000154)3.15665375
53purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.14843964
54transmission of nerve impulse (GO:0019226)3.12896282
55purine nucleoside triphosphate biosynthetic process (GO:0009145)3.09804259
56intracellular protein transmembrane import (GO:0044743)3.06041156
57nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.04759269
58ATP biosynthetic process (GO:0006754)3.01185767
59cellular ketone body metabolic process (GO:0046950)3.00924183
60protein polyglutamylation (GO:0018095)3.00387645
61regulation of telomere maintenance (GO:0032204)2.98905315
62positive regulation of embryonic development (GO:0040019)2.98268700
63UTP biosynthetic process (GO:0006228)2.97147774
64proton transport (GO:0015992)2.95595015
65ribonucleoside triphosphate biosynthetic process (GO:0009201)2.95474560
66termination of RNA polymerase III transcription (GO:0006386)2.94948159
67transcription elongation from RNA polymerase III promoter (GO:0006385)2.94948159
68pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.91467893
69positive regulation of response to oxidative stress (GO:1902884)2.91357948
70positive regulation of cellular response to oxidative stress (GO:1900409)2.91357948
71hydrogen transport (GO:0006818)2.90628084
72interferon-gamma production (GO:0032609)2.87482749
73arginine catabolic process (GO:0006527)2.84891707
74positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.83807557
75pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.83417568
76head development (GO:0060322)2.81777900
77rRNA processing (GO:0006364)2.81235205
78apoptotic DNA fragmentation (GO:0006309)2.79788816
79translational initiation (GO:0006413)2.79401684
80translation (GO:0006412)2.78489655
81pseudouridine synthesis (GO:0001522)2.77547595
82positive regulation of triglyceride biosynthetic process (GO:0010867)2.76687731
83rRNA metabolic process (GO:0016072)2.76326583
84DNA replication checkpoint (GO:0000076)2.72491771
85establishment of protein localization to mitochondrion (GO:0072655)2.72246420
86pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.71407259
87cell junction maintenance (GO:0034331)2.70053429
88regulation of helicase activity (GO:0051095)2.69995624
89nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.68120342
90cerebral cortex radially oriented cell migration (GO:0021799)2.67032471
91guanosine-containing compound biosynthetic process (GO:1901070)2.65836084
92ketone body metabolic process (GO:1902224)2.65569507
93negative regulation of macroautophagy (GO:0016242)2.63731097
94myoblast migration (GO:0051451)2.63275009
95protein complex disassembly (GO:0043241)2.63017537
96positive regulation of sodium ion transmembrane transport (GO:1902307)2.62817634
97positive regulation of prostaglandin secretion (GO:0032308)2.62692565
98dopaminergic neuron differentiation (GO:0071542)2.62115913
99cell proliferation in forebrain (GO:0021846)2.59127608
100UTP metabolic process (GO:0046051)2.58110345

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.59889229
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.88197054
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.49044937
4VDR_22108803_ChIP-Seq_LS180_Human3.22227157
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.07410163
6EZH2_22144423_ChIP-Seq_EOC_Human2.97938367
7ZNF274_21170338_ChIP-Seq_K562_Hela2.97544773
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.76499082
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.74920101
10GABP_17652178_ChIP-ChIP_JURKAT_Human2.65193153
11SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.62387059
12HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.58748215
13BMI1_23680149_ChIP-Seq_NPCS_Mouse2.23869066
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.20311401
15MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.12752972
16CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.05216895
17NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.04833077
18TP63_19390658_ChIP-ChIP_HaCaT_Human1.99233407
19CBX2_27304074_Chip-Seq_ESCs_Mouse1.97407629
20ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.90750273
21EZH2_27304074_Chip-Seq_ESCs_Mouse1.90254376
22EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.88034425
23JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.75531571
24EED_16625203_ChIP-ChIP_MESCs_Mouse1.72194223
25REST_21632747_ChIP-Seq_MESCs_Mouse1.66624658
26ELF1_17652178_ChIP-ChIP_JURKAT_Human1.62458042
27CTBP1_25329375_ChIP-Seq_LNCAP_Human1.60972334
28EWS_26573619_Chip-Seq_HEK293_Human1.58797217
29MYC_18940864_ChIP-ChIP_HL60_Human1.54510163
30EZH2_27294783_Chip-Seq_ESCs_Mouse1.53843308
31PCGF2_27294783_Chip-Seq_NPCs_Mouse1.49776063
32IRF1_19129219_ChIP-ChIP_H3396_Human1.45883689
33SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.44216374
34JARID2_20064375_ChIP-Seq_MESCs_Mouse1.42092681
35MYC_18555785_ChIP-Seq_MESCs_Mouse1.35394119
36ZFP57_27257070_Chip-Seq_ESCs_Mouse1.30368377
37CREB1_15753290_ChIP-ChIP_HEK293T_Human1.30273904
38MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.29613756
39JARID2_20075857_ChIP-Seq_MESCs_Mouse1.29328624
40RNF2_27304074_Chip-Seq_NSC_Mouse1.28484900
41ER_23166858_ChIP-Seq_MCF-7_Human1.27649463
42ELK1_19687146_ChIP-ChIP_HELA_Human1.27308696
43VDR_23849224_ChIP-Seq_CD4+_Human1.24528363
44CTBP2_25329375_ChIP-Seq_LNCAP_Human1.24002425
45SUZ12_27294783_Chip-Seq_ESCs_Mouse1.22757290
46YY1_21170310_ChIP-Seq_MESCs_Mouse1.22672574
47GBX2_23144817_ChIP-Seq_PC3_Human1.22557087
48SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.21966159
49RNF2_27304074_Chip-Seq_ESCs_Mouse1.21790919
50RBPJ_22232070_ChIP-Seq_NCS_Mouse1.20883510
51SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.19283601
52NOTCH1_21737748_ChIP-Seq_TLL_Human1.18313819
53FUS_26573619_Chip-Seq_HEK293_Human1.17995650
54ERA_21632823_ChIP-Seq_H3396_Human1.17548573
55MYC_18358816_ChIP-ChIP_MESCs_Mouse1.17460207
56CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.16760110
57SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.15009052
58GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.14024252
59CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.13275374
60POU5F1_16153702_ChIP-ChIP_HESCs_Human1.12241315
61PCGF2_27294783_Chip-Seq_ESCs_Mouse1.10247153
62THAP11_20581084_ChIP-Seq_MESCs_Mouse1.10158997
63POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.10095253
64EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.09379703
65EZH2_18974828_ChIP-Seq_MESCs_Mouse1.07506748
66RNF2_18974828_ChIP-Seq_MESCs_Mouse1.07506748
67TTF2_22483619_ChIP-Seq_HELA_Human1.07287963
68FLI1_27457419_Chip-Seq_LIVER_Mouse1.07128804
69SRF_21415370_ChIP-Seq_HL-1_Mouse1.06651777
70TP53_22573176_ChIP-Seq_HFKS_Human1.06371229
71TAF2_19829295_ChIP-Seq_ESCs_Human1.05778322
72XRN2_22483619_ChIP-Seq_HELA_Human1.05051708
73PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.02993044
74ETV2_25802403_ChIP-Seq_MESCs_Mouse1.02152224
75P300_19829295_ChIP-Seq_ESCs_Human1.01323180
76MYC_19829295_ChIP-Seq_ESCs_Human1.00261932
77LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96237559
78GATA3_21878914_ChIP-Seq_MCF-7_Human0.95709088
79TDRD3_21172665_ChIP-Seq_MCF-7_Human0.95322336
80GATA1_26923725_Chip-Seq_HPCs_Mouse0.95297710
81REST_18959480_ChIP-ChIP_MESCs_Mouse0.95234133
82NCOR_22424771_ChIP-Seq_293T_Human0.94823034
83PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.94500865
84FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.92872346
85GABP_19822575_ChIP-Seq_HepG2_Human0.92406721
86PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.91142067
87HTT_18923047_ChIP-ChIP_STHdh_Human0.90841350
88SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.89791620
89IKZF1_21737484_ChIP-ChIP_HCT116_Human0.89465310
90STAT1_20625510_ChIP-Seq_HELA_Human0.89442699
91MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.88879226
92EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.87392230
93HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.87089432
94CTCF_18555785_ChIP-Seq_MESCs_Mouse0.86689070
95NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.86574413
96FOXP3_21729870_ChIP-Seq_TREG_Human0.86305427
97DCP1A_22483619_ChIP-Seq_HELA_Human0.85903865
98FOXH1_21741376_ChIP-Seq_EPCs_Human0.85170635
99TOP2B_26459242_ChIP-Seq_MCF-7_Human0.84650783
100E2F4_17652178_ChIP-ChIP_JURKAT_Human0.84360947

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001485_abnormal_pinna_reflex3.55903758
2MP0006292_abnormal_olfactory_placode3.25911273
3MP0004133_heterotaxia3.17392715
4MP0003283_abnormal_digestive_organ2.88430619
5MP0009379_abnormal_foot_pigmentation2.86270554
6MP0004742_abnormal_vestibular_system2.78931286
7MP0003693_abnormal_embryo_hatching2.65218759
8MP0008875_abnormal_xenobiotic_pharmacok2.64250344
9MP0002163_abnormal_gland_morphology2.58149757
10MP0005084_abnormal_gallbladder_morpholo2.45938712
11MP0002102_abnormal_ear_morphology2.34365837
12MP0006276_abnormal_autonomic_nervous2.31590510
13MP0000566_synostosis2.28369618
14MP0004145_abnormal_muscle_electrophysio2.15568512
15MP0001529_abnormal_vocalization2.13461531
16MP0000631_abnormal_neuroendocrine_gland2.00038429
17MP0002837_dystrophic_cardiac_calcinosis1.89749402
18MP0005379_endocrine/exocrine_gland_phen1.88046759
19MP0009745_abnormal_behavioral_response1.85165151
20MP0004270_analgesia1.84820970
21MP0003136_yellow_coat_color1.83690519
22MP0005645_abnormal_hypothalamus_physiol1.77090973
23MP0001905_abnormal_dopamine_level1.75035383
24MP0003646_muscle_fatigue1.70638107
25MP0002735_abnormal_chemical_nociception1.67805672
26MP0001293_anophthalmia1.65924145
27MP0005646_abnormal_pituitary_gland1.61267125
28MP0002736_abnormal_nociception_after1.60643370
29MP0004885_abnormal_endolymph1.58597457
30MP0002277_abnormal_respiratory_mucosa1.55333538
31MP0005085_abnormal_gallbladder_physiolo1.54740134
32MP0000049_abnormal_middle_ear1.54482491
33MP0003879_abnormal_hair_cell1.53185861
34MP0002064_seizures1.47904876
35MP0002272_abnormal_nervous_system1.44365098
36MP0002734_abnormal_mechanical_nocicepti1.41866506
37MP0002733_abnormal_thermal_nociception1.39505245
38MP0001968_abnormal_touch/_nociception1.37078987
39MP0004142_abnormal_muscle_tone1.35683205
40MP0001177_atelectasis1.35257639
41MP0003635_abnormal_synaptic_transmissio1.33793689
42MP0002938_white_spotting1.31724642
43MP0000778_abnormal_nervous_system1.27303462
44MP0002160_abnormal_reproductive_system1.25350444
45MP0001970_abnormal_pain_threshold1.23780183
46MP0002876_abnormal_thyroid_physiology1.20099129
47MP0008789_abnormal_olfactory_epithelium1.18818741
48MP0000955_abnormal_spinal_cord1.16626532
49MP0009053_abnormal_anal_canal1.16027916
50MP0002138_abnormal_hepatobiliary_system1.13471051
51MP0002572_abnormal_emotion/affect_behav1.13411016
52MP0009046_muscle_twitch1.12416328
53MP0001963_abnormal_hearing_physiology1.12014511
54MP0003011_delayed_dark_adaptation1.11690468
55MP0003787_abnormal_imprinting1.11413061
56MP0002067_abnormal_sensory_capabilities1.11349440
57MP0008775_abnormal_heart_ventricle1.10885447
58MP0003137_abnormal_impulse_conducting1.10274804
59MP0008872_abnormal_physiological_respon1.04152690
60MP0003123_paternal_imprinting1.03819008
61MP0000026_abnormal_inner_ear1.03035381
62MP0003878_abnormal_ear_physiology1.03030328
63MP0005377_hearing/vestibular/ear_phenot1.03030328
64MP0005551_abnormal_eye_electrophysiolog1.02412899
65MP0002063_abnormal_learning/memory/cond1.02022227
66MP0002234_abnormal_pharynx_morphology0.99833594
67MP0001501_abnormal_sleep_pattern0.98772924
68MP0002653_abnormal_ependyma_morphology0.97936297
69MP0001919_abnormal_reproductive_system0.97932550
70MP0003938_abnormal_ear_development0.97298164
71MP0005195_abnormal_posterior_eye0.96571726
72MP0005408_hypopigmentation0.95488254
73MP0003122_maternal_imprinting0.95434153
74MP0002752_abnormal_somatic_nervous0.93178456
75MP0003121_genomic_imprinting0.91830568
76MP0004924_abnormal_behavior0.91705471
77MP0005386_behavior/neurological_phenoty0.91705471
78MP0002557_abnormal_social/conspecific_i0.90995341
79MP0005499_abnormal_olfactory_system0.90407776
80MP0005394_taste/olfaction_phenotype0.90407776
81MP0005389_reproductive_system_phenotype0.88899863
82MP0006036_abnormal_mitochondrial_physio0.86621505
83MP0004215_abnormal_myocardial_fiber0.85561847
84MP0002638_abnormal_pupillary_reflex0.85352883
85MP0001486_abnormal_startle_reflex0.85138076
86MP0002229_neurodegeneration0.84228978
87MP0003880_abnormal_central_pattern0.84184884
88MP0005423_abnormal_somatic_nervous0.83128351
89MP0002882_abnormal_neuron_morphology0.83076888
90MP0002822_catalepsy0.82099248
91MP0008877_abnormal_DNA_methylation0.81165433
92MP0003718_maternal_effect0.80621994
93MP0003937_abnormal_limbs/digits/tail_de0.79857890
94MP0005448_abnormal_energy_balance0.76332867
95MP0004811_abnormal_neuron_physiology0.76111997
96MP0002909_abnormal_adrenal_gland0.74959306
97MP0004043_abnormal_pH_regulation0.73968817
98MP0005167_abnormal_blood-brain_barrier0.73384656
99MP0002127_abnormal_cardiovascular_syste0.73364203
100MP0003252_abnormal_bile_duct0.72711511

Predicted human phenotypes

RankGene SetZ-score
1Decreased circulating renin level (HP:0003351)4.53705323
2Bilateral microphthalmos (HP:0007633)4.41030232
3Acute necrotizing encephalopathy (HP:0006965)4.26853664
4Mitochondrial inheritance (HP:0001427)4.19449407
5Hepatocellular necrosis (HP:0001404)4.07465323
6Increased CSF lactate (HP:0002490)4.02766793
7Type II lissencephaly (HP:0007260)3.87252177
8Cerebellar dysplasia (HP:0007033)3.69215059
9Increased hepatocellular lipid droplets (HP:0006565)3.66000571
10Reticulocytopenia (HP:0001896)3.63036527
11Hepatic necrosis (HP:0002605)3.58839260
12Abnormal mitochondria in muscle tissue (HP:0008316)3.55697325
13Acute encephalopathy (HP:0006846)3.53690176
14Progressive macrocephaly (HP:0004481)3.49055902
15Renal Fanconi syndrome (HP:0001994)3.27374286
16Lipid accumulation in hepatocytes (HP:0006561)3.19860551
17Abnormality of the aortic arch (HP:0012303)3.19766196
18Esophageal atresia (HP:0002032)3.12612165
19Pendular nystagmus (HP:0012043)3.05223882
20Pancreatic cysts (HP:0001737)3.04386055
21Polydipsia (HP:0001959)3.03449980
22Abnormal drinking behavior (HP:0030082)3.03449980
23Abnormality of the labia minora (HP:0012880)2.87287370
24Gastrointestinal atresia (HP:0002589)2.85878682
25Retinal dysplasia (HP:0007973)2.82558860
26Pancreatic fibrosis (HP:0100732)2.80506873
27Male pseudohermaphroditism (HP:0000037)2.75516925
28Absent thumb (HP:0009777)2.69212781
29True hermaphroditism (HP:0010459)2.68064335
30Abnormality of renin-angiotensin system (HP:0000847)2.66097087
31Optic disc pallor (HP:0000543)2.59285861
32Anophthalmia (HP:0000528)2.58971579
33Abnormality of midbrain morphology (HP:0002418)2.58939735
34Molar tooth sign on MRI (HP:0002419)2.58939735
35Sclerocornea (HP:0000647)2.57827657
36Increased serum lactate (HP:0002151)2.57405067
37Cleft eyelid (HP:0000625)2.50299130
38Nephronophthisis (HP:0000090)2.47520023
39Limb dystonia (HP:0002451)2.44276443
403-Methylglutaconic aciduria (HP:0003535)2.40100056
41Papilledema (HP:0001085)2.38726976
42Chronic hepatic failure (HP:0100626)2.36786895
43Anterior segment dysgenesis (HP:0007700)2.35379112
44Cerebral edema (HP:0002181)2.34453947
45Septo-optic dysplasia (HP:0100842)2.28256863
46Increased serum pyruvate (HP:0003542)2.27753584
47Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.22444654
48Inability to walk (HP:0002540)2.22343646
49Abnormality of renal resorption (HP:0011038)2.21380469
50Birth length less than 3rd percentile (HP:0003561)2.21269666
51Hypomagnesemia (HP:0002917)2.19662777
52Fetal akinesia sequence (HP:0001989)2.17950601
53Multiple enchondromatosis (HP:0005701)2.17618300
54Respiratory failure (HP:0002878)2.13198524
55Morphological abnormality of the middle ear (HP:0008609)2.12553685
56Macrocytic anemia (HP:0001972)2.12064452
57Myokymia (HP:0002411)2.09661843
58Exertional dyspnea (HP:0002875)2.09180854
59Abnormal number of erythroid precursors (HP:0012131)2.09013808
60Polyuria (HP:0000103)2.08411955
61Abnormality of the lacrimal duct (HP:0011481)2.06344865
62Abnormality of cells of the erythroid lineage (HP:0012130)2.04362749
63Abnormality of magnesium homeostasis (HP:0004921)2.03872819
64Abnormality of the ileum (HP:0001549)2.02772784
65Leukodystrophy (HP:0002415)2.02714413
66Facial cleft (HP:0002006)1.99908124
67Congenital stationary night blindness (HP:0007642)1.99195699
68Aplasia/Hypoplasia of the patella (HP:0006498)1.97329958
69Patellar aplasia (HP:0006443)1.96728564
70CNS demyelination (HP:0007305)1.95314160
71Abnormality of the renal cortex (HP:0011035)1.93496218
72Intestinal atresia (HP:0011100)1.93436317
73Increased intramyocellular lipid droplets (HP:0012240)1.92400224
74Abolished electroretinogram (ERG) (HP:0000550)1.91622851
75Neonatal respiratory distress (HP:0002643)1.89047445
76Abnormality of the nasolacrimal system (HP:0000614)1.88741575
77Lissencephaly (HP:0001339)1.88563717
78Lactic acidosis (HP:0003128)1.88307625
79Abnormality of the renal medulla (HP:0100957)1.85463903
80Scrotal hypoplasia (HP:0000046)1.83621972
81Colon cancer (HP:0003003)1.82908964
82Female pseudohermaphroditism (HP:0010458)1.82607388
83Aplasia/Hypoplasia of the uvula (HP:0010293)1.82514607
84Progressive inability to walk (HP:0002505)1.82311436
85Occipital encephalocele (HP:0002085)1.81599680
86Hypoplasia of the radius (HP:0002984)1.81283161
87Aplasia/Hypoplasia of the sternum (HP:0006714)1.81168291
88Volvulus (HP:0002580)1.79750929
89Pallor (HP:0000980)1.78652387
90Abnormal respiratory epithelium morphology (HP:0012253)1.75917981
91Abnormal respiratory motile cilium morphology (HP:0005938)1.75917981
92Glycosuria (HP:0003076)1.75032589
93Abnormality of urine glucose concentration (HP:0011016)1.75032589
94Supernumerary bones of the axial skeleton (HP:0009144)1.74814469
95Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.74717678
96Optic nerve hypoplasia (HP:0000609)1.74335102
97Abnormal lung lobation (HP:0002101)1.74314052
98Ectopic kidney (HP:0000086)1.72627514
99Anencephaly (HP:0002323)1.70509150
100Cerebral hypomyelination (HP:0006808)1.70057404

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK25.46389129
2WNK34.78099359
3SIK24.57044738
4MAP4K24.08134550
5TLK13.53769803
6WNK43.00546808
7MAP2K62.78536496
8INSRR2.73311195
9NUAK12.71697695
10NEK22.38399649
11PNCK2.33090212
12FRK2.18672337
13CASK2.10298495
14CDK191.71888768
15TESK11.70281934
16STK161.69479412
17ADRBK21.60503574
18GRK11.58511529
19DYRK21.55733565
20OXSR11.55070415
21VRK21.51834538
22STK391.35701602
23TNIK1.34347756
24PRKD31.28631055
25NME21.25645562
26MAP2K71.24734628
27NME11.24075073
28STK381.19504373
29EPHB21.14991888
30MARK11.14132224
31TIE11.08915010
32CAMKK21.04796279
33PAK31.03689482
34PRKCG0.99288157
35MINK10.96193257
36BMPR1B0.95284004
37PIK3CA0.93468301
38TAF10.90185802
39MAP3K50.89930657
40TAOK30.87901044
41STK40.86668958
42NTRK20.86455078
43WEE10.85380952
44TSSK60.83885998
45MAPKAPK50.83590352
46PINK10.79372669
47ZAK0.73106648
48STK110.70203773
49MAPK130.68185732
50NEK10.65498787
51PLK40.62663373
52MKNK20.62492324
53CCNB10.60979473
54BUB10.60701051
55AURKA0.55636970
56RPS6KA40.55474251
57MST40.54225625
58ALK0.50623983
59STK30.47342124
60DAPK20.46837904
61MAP3K40.46629304
62PRKACA0.45530468
63RPS6KA50.45462101
64TXK0.45377905
65PRKCI0.44379601
66CSNK1A10.44161910
67CHEK20.43392851
68VRK10.42539370
69IRAK40.38232916
70CAMKK10.37704515
71CSNK1G20.36806468
72CSNK1G30.36453155
73IRAK10.36397307
74ADRBK10.35204345
75TNK20.35069112
76OBSCN0.34644427
77GRK50.34591183
78ATR0.33857383
79MAP3K80.33702896
80CSNK1E0.33694605
81MAPKAPK30.28956592
82LRRK20.28953439
83CSNK2A20.28175029
84PRKCH0.27510406
85CAMK10.26657025
86PRKCQ0.26487961
87PRKG20.26224711
88CAMK2A0.26059717
89PRKCA0.25674838
90PDK20.25218668
91PHKG10.22799973
92PHKG20.22799973
93DMPK0.22340252
94PLK10.22177483
95CSNK2A10.21623192
96BRSK10.19616247
97PRKG10.19358912
98GRK70.19007394
99TGFBR10.18306917
100CSNK1G10.17932260

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.46124725
2Ribosome_Homo sapiens_hsa030104.31838963
3Parkinsons disease_Homo sapiens_hsa050123.93250063
4Cardiac muscle contraction_Homo sapiens_hsa042602.97145895
5Alzheimers disease_Homo sapiens_hsa050102.65467122
6Huntingtons disease_Homo sapiens_hsa050162.64973340
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.64425112
8Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.55019906
9Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.43327911
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.31804136
11RNA polymerase_Homo sapiens_hsa030202.18160432
12Proteasome_Homo sapiens_hsa030501.92495870
13Homologous recombination_Homo sapiens_hsa034401.84076404
14alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.71464558
15Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.57793959
16Linoleic acid metabolism_Homo sapiens_hsa005911.55830549
17One carbon pool by folate_Homo sapiens_hsa006701.47042552
18Butanoate metabolism_Homo sapiens_hsa006501.46382331
19Protein export_Homo sapiens_hsa030601.44293282
20Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.41542906
21Pyrimidine metabolism_Homo sapiens_hsa002401.37058614
22Nicotine addiction_Homo sapiens_hsa050331.35311914
23Phototransduction_Homo sapiens_hsa047441.32115209
24Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.31940601
25Fanconi anemia pathway_Homo sapiens_hsa034601.30739499
26Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.29758230
27Fatty acid degradation_Homo sapiens_hsa000711.29261510
28Tryptophan metabolism_Homo sapiens_hsa003801.27865704
29Caffeine metabolism_Homo sapiens_hsa002321.23182320
30SNARE interactions in vesicular transport_Homo sapiens_hsa041301.22124538
31RNA degradation_Homo sapiens_hsa030181.18171437
32Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.17252994
33Sulfur relay system_Homo sapiens_hsa041221.15548102
34Vitamin B6 metabolism_Homo sapiens_hsa007501.15083005
35Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.13791727
36Propanoate metabolism_Homo sapiens_hsa006401.09979820
37RNA transport_Homo sapiens_hsa030131.08587975
38Purine metabolism_Homo sapiens_hsa002301.05891118
39Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.04678983
40Basal transcription factors_Homo sapiens_hsa030221.04533391
41Folate biosynthesis_Homo sapiens_hsa007900.97887677
42Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.97229213
43DNA replication_Homo sapiens_hsa030300.89897007
44Selenocompound metabolism_Homo sapiens_hsa004500.89246200
45Fat digestion and absorption_Homo sapiens_hsa049750.88124026
46Steroid biosynthesis_Homo sapiens_hsa001000.87417808
47Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.84436697
48Pyruvate metabolism_Homo sapiens_hsa006200.81942619
49Nucleotide excision repair_Homo sapiens_hsa034200.80873459
50Mismatch repair_Homo sapiens_hsa034300.78971651
51Morphine addiction_Homo sapiens_hsa050320.78272597
52Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.78042520
53Retinol metabolism_Homo sapiens_hsa008300.76198630
54Nitrogen metabolism_Homo sapiens_hsa009100.75669147
55Maturity onset diabetes of the young_Homo sapiens_hsa049500.75003167
56GABAergic synapse_Homo sapiens_hsa047270.74197059
57Metabolic pathways_Homo sapiens_hsa011000.74003619
58Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.73370810
59Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.72636674
60Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.70399419
61Peroxisome_Homo sapiens_hsa041460.69891660
62Taste transduction_Homo sapiens_hsa047420.67439501
63Spliceosome_Homo sapiens_hsa030400.64897075
64Ether lipid metabolism_Homo sapiens_hsa005650.63443401
65Fatty acid metabolism_Homo sapiens_hsa012120.62839331
66Serotonergic synapse_Homo sapiens_hsa047260.62411892
67Cysteine and methionine metabolism_Homo sapiens_hsa002700.61068375
68Tyrosine metabolism_Homo sapiens_hsa003500.61004489
69beta-Alanine metabolism_Homo sapiens_hsa004100.60533119
70Primary immunodeficiency_Homo sapiens_hsa053400.58817002
71Steroid hormone biosynthesis_Homo sapiens_hsa001400.57136224
72Circadian entrainment_Homo sapiens_hsa047130.56625704
73Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.56624762
74Cocaine addiction_Homo sapiens_hsa050300.56161568
75Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.56075805
76Histidine metabolism_Homo sapiens_hsa003400.54807925
77ABC transporters_Homo sapiens_hsa020100.52777071
78Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.52503562
79Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.51830207
80Glutamatergic synapse_Homo sapiens_hsa047240.51036153
81Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.50798307
82Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.50295107
83Pentose and glucuronate interconversions_Homo sapiens_hsa000400.49005666
84Chemical carcinogenesis_Homo sapiens_hsa052040.48667977
85Arachidonic acid metabolism_Homo sapiens_hsa005900.48465277
86Asthma_Homo sapiens_hsa053100.47313877
87Regulation of autophagy_Homo sapiens_hsa041400.44390709
88Basal cell carcinoma_Homo sapiens_hsa052170.44384649
89Primary bile acid biosynthesis_Homo sapiens_hsa001200.42269185
90Collecting duct acid secretion_Homo sapiens_hsa049660.42164635
91Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.40333476
92Drug metabolism - other enzymes_Homo sapiens_hsa009830.40147954
93Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.39210109
94Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.35340346
95Sulfur metabolism_Homo sapiens_hsa009200.35221490
96PPAR signaling pathway_Homo sapiens_hsa033200.34603581
97Dopaminergic synapse_Homo sapiens_hsa047280.32872162
98Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.32571570
99Mineral absorption_Homo sapiens_hsa049780.30489682
100Intestinal immune network for IgA production_Homo sapiens_hsa046720.30151391

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