FABP5P7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1keratinization (GO:0031424)8.10618581
2establishment of skin barrier (GO:0061436)6.57801445
3regulation of water loss via skin (GO:0033561)5.43434648
4keratinocyte differentiation (GO:0030216)5.12258741
5proteasome assembly (GO:0043248)4.65796842
6mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.50707810
7hair cycle (GO:0042633)4.18829628
8molting cycle (GO:0042303)4.18829628
9ribosome assembly (GO:0042255)4.09547379
10establishment of protein localization to mitochondrial membrane (GO:0090151)4.07103463
11energy coupled proton transport, down electrochemical gradient (GO:0015985)3.97949375
12ATP synthesis coupled proton transport (GO:0015986)3.97949375
13negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.93869344
14epidermal cell differentiation (GO:0009913)3.89854549
15regulation of cellular amino acid metabolic process (GO:0006521)3.89119354
16positive regulation of monocyte chemotaxis (GO:0090026)3.87508403
17desmosome organization (GO:0002934)3.83839625
18positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.77067374
19bundle of His cell to Purkinje myocyte communication (GO:0086069)3.67026585
20DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.64900423
21establishment of integrated proviral latency (GO:0075713)3.64187994
22regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.63183167
23negative regulation of ligase activity (GO:0051352)3.61346402
24negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.61346402
25signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.59692758
26signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.59692758
27signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.59692758
28intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.58017888
29signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.58017888
30respiratory chain complex IV assembly (GO:0008535)3.56915071
31maturation of 5.8S rRNA (GO:0000460)3.54320709
32DNA double-strand break processing (GO:0000729)3.50459191
33signal transduction involved in DNA damage checkpoint (GO:0072422)3.45997225
34signal transduction involved in DNA integrity checkpoint (GO:0072401)3.45997225
35chaperone-mediated protein transport (GO:0072321)3.45874000
36signal transduction involved in cell cycle checkpoint (GO:0072395)3.40672967
37protein complex biogenesis (GO:0070271)3.37171784
38peptide cross-linking (GO:0018149)3.35365779
39rRNA modification (GO:0000154)3.35122344
40anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.34286032
41DNA deamination (GO:0045006)3.33032254
42mitochondrial respiratory chain complex assembly (GO:0033108)3.30291964
43pseudouridine synthesis (GO:0001522)3.29683174
44sequestering of metal ion (GO:0051238)3.27994401
45transcription elongation from RNA polymerase III promoter (GO:0006385)3.27191722
46termination of RNA polymerase III transcription (GO:0006386)3.27191722
47positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.23008064
48mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.22404698
49mitochondrial respiratory chain complex I assembly (GO:0032981)3.22404698
50NADH dehydrogenase complex assembly (GO:0010257)3.22404698
51nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.19101939
52antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.19077015
53exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.17585594
54DNA catabolic process, exonucleolytic (GO:0000738)3.13018256
55multicellular organismal water homeostasis (GO:0050891)3.12987668
56antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.12047574
57positive regulation of ligase activity (GO:0051351)3.09984180
58protein targeting to mitochondrion (GO:0006626)3.09470677
59IMP biosynthetic process (GO:0006188)3.09434028
60respiratory electron transport chain (GO:0022904)3.07641166
61keratinocyte proliferation (GO:0043616)3.04950135
62cytochrome complex assembly (GO:0017004)3.02990022
63electron transport chain (GO:0022900)3.01335926
64epidermis development (GO:0008544)2.99456877
65mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.99405574
66tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.99105133
67RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.99105133
68oxidative phosphorylation (GO:0006119)2.98480855
69phosphatidylinositol acyl-chain remodeling (GO:0036149)2.97267219
70viral mRNA export from host cell nucleus (GO:0046784)2.95743187
71rRNA processing (GO:0006364)2.94996703
72establishment of viral latency (GO:0019043)2.92643889
73purine nucleobase biosynthetic process (GO:0009113)2.92393039
74response to X-ray (GO:0010165)2.92048443
75regulation of mitochondrial translation (GO:0070129)2.91372754
76DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.90527572
77deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.83618875
78rRNA metabolic process (GO:0016072)2.83194243
79nucleobase biosynthetic process (GO:0046112)2.81013140
80protein localization to mitochondrion (GO:0070585)2.80101474
81regulation of ubiquitin-protein transferase activity (GO:0051438)2.79782749
82positive regulation of cell cycle arrest (GO:0071158)2.79206108
83establishment of protein localization to mitochondrion (GO:0072655)2.78836792
84negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 2.78348930
85regulation of cellular amine metabolic process (GO:0033238)2.75940254
86rRNA methylation (GO:0031167)2.75028428
87ribosomal large subunit biogenesis (GO:0042273)2.71814224
88platelet dense granule organization (GO:0060155)2.71547318
89regulation of ligase activity (GO:0051340)2.70726236
90ribosome biogenesis (GO:0042254)2.70502383
91IMP metabolic process (GO:0046040)2.70230896
92negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.70213799
93cullin deneddylation (GO:0010388)2.70212476
94RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.68467230
95negative regulation of protein ubiquitination (GO:0031397)2.66270627
96intermediate filament organization (GO:0045109)2.64929408
97protein maturation by protein folding (GO:0022417)2.64389720
98L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.64330301
99phosphatidylserine acyl-chain remodeling (GO:0036150)2.64278164
100non-recombinational repair (GO:0000726)2.62795128

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.41006337
2E2F7_22180533_ChIP-Seq_HELA_Human4.75882127
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.45122035
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.86309526
5TP63_17297297_ChIP-ChIP_HaCaT_Human3.79648724
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.60366764
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.47775707
8ELF1_17652178_ChIP-ChIP_JURKAT_Human3.34102818
9MYC_18555785_ChIP-Seq_MESCs_Mouse3.33347960
10ETS1_20019798_ChIP-Seq_JURKAT_Human3.13584692
11CREB1_15753290_ChIP-ChIP_HEK293T_Human2.79777451
12CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.78123376
13CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.66295794
14VDR_23849224_ChIP-Seq_CD4+_Human2.54938278
15EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.52046025
16HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.43100062
17MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.41582430
18E2F4_17652178_ChIP-ChIP_JURKAT_Human2.40159455
19ELK1_19687146_ChIP-ChIP_HELA_Human2.33702121
20MYC_18358816_ChIP-ChIP_MESCs_Mouse2.33127484
21MYC_19030024_ChIP-ChIP_MESCs_Mouse2.29446976
22SRF_21415370_ChIP-Seq_HL-1_Mouse2.16465412
23FOXP3_21729870_ChIP-Seq_TREG_Human2.15787557
24FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.02590876
25DCP1A_22483619_ChIP-Seq_HELA_Human2.01692023
26PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.95341223
27MYC_19079543_ChIP-ChIP_MESCs_Mouse1.86296092
28E2F1_18555785_ChIP-Seq_MESCs_Mouse1.81389653
29PADI4_21655091_ChIP-ChIP_MCF-7_Human1.73201231
30E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.71798513
31GABP_19822575_ChIP-Seq_HepG2_Human1.70754009
32HOXB4_20404135_ChIP-ChIP_EML_Mouse1.68826009
33PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.67028562
34HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.62899468
35NELFA_20434984_ChIP-Seq_ESCs_Mouse1.61919489
36BP1_19119308_ChIP-ChIP_Hs578T_Human1.56065574
37ZNF274_21170338_ChIP-Seq_K562_Hela1.54698826
38FLI1_27457419_Chip-Seq_LIVER_Mouse1.52153338
39TTF2_22483619_ChIP-Seq_HELA_Human1.51134007
40SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.48778219
41THAP11_20581084_ChIP-Seq_MESCs_Mouse1.48440993
42NOTCH1_21737748_ChIP-Seq_TLL_Human1.43262636
43SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.43072437
44HTT_18923047_ChIP-ChIP_STHdh_Human1.38420593
45VDR_22108803_ChIP-Seq_LS180_Human1.38187312
46CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.36525055
47TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.34686749
48FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.28077933
49ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.27272532
50IRF8_21731497_ChIP-ChIP_J774_Mouse1.26971369
51MYCN_18555785_ChIP-Seq_MESCs_Mouse1.25553628
52YY1_21170310_ChIP-Seq_MESCs_Mouse1.24594618
53FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.23888752
54CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.21259417
55YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.20649360
56ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.20550130
57AR_21909140_ChIP-Seq_LNCAP_Human1.19022887
58POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.14189807
59SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.13009411
60KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.12789779
61E2F1_21310950_ChIP-Seq_MCF-7_Human1.10541011
62ELK1_22589737_ChIP-Seq_MCF10A_Human1.10437850
63PCGF2_27294783_Chip-Seq_ESCs_Mouse1.10385473
64TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.06542928
65MYC_18940864_ChIP-ChIP_HL60_Human1.04999198
66IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.04570894
67ERG_20887958_ChIP-Seq_HPC-7_Mouse1.02410882
68KDM5A_27292631_Chip-Seq_BREAST_Human1.02115279
69ELF5_23300383_ChIP-Seq_T47D_Human0.99433077
70E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.99304551
71HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.98030802
72CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.96407758
73XRN2_22483619_ChIP-Seq_HELA_Human0.95235825
74MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.95023099
75ERG_20517297_ChIP-Seq_VCAP_Human0.94970840
76TFEB_21752829_ChIP-Seq_HELA_Human0.94417041
77GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.91603924
78SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.91139768
79SPI1_23547873_ChIP-Seq_NB4_Human0.89843609
80POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.88775034
81NANOG_18555785_ChIP-Seq_MESCs_Mouse0.87387079
82ZFX_18555785_ChIP-Seq_MESCs_Mouse0.86803577
83EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.84613330
84EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.84156228
85GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.83828356
86SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.83495939
87STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.83174366
88PCGF2_27294783_Chip-Seq_NPCs_Mouse0.81707867
89TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.81285141
90EWS_26573619_Chip-Seq_HEK293_Human0.81106351
91RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.80785094
92FOXA1_27270436_Chip-Seq_PROSTATE_Human0.80052019
93FOXA1_25329375_ChIP-Seq_VCAP_Human0.80052019
94AR_20517297_ChIP-Seq_VCAP_Human0.78926144
95RBPJ_21746931_ChIP-Seq_IB4_Human0.78395544
96NCOR_22424771_ChIP-Seq_293T_Human0.77475503
97PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.77361649
98GATA3_26560356_Chip-Seq_TH2_Human0.77310439
99CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.76165785
100GATA6_21074721_ChIP-Seq_CACO-2_Human0.75657400

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier7.46076988
2MP0000579_abnormal_nail_morphology4.31261459
3MP0005501_abnormal_skin_physiology4.15005114
4MP0003806_abnormal_nucleotide_metabolis3.66499704
5MP0010234_abnormal_vibrissa_follicle3.60434639
6MP0005275_abnormal_skin_tensile2.97060884
7MP0004885_abnormal_endolymph2.76554055
8MP0001216_abnormal_epidermal_layer2.71110449
9MP0005377_hearing/vestibular/ear_phenot2.69605715
10MP0003878_abnormal_ear_physiology2.69605715
11MP0003941_abnormal_skin_development2.64948524
12MP0010678_abnormal_skin_adnexa2.47760958
13MP0008058_abnormal_DNA_repair2.46835804
14MP0000383_abnormal_hair_follicle2.32784115
15MP0010094_abnormal_chromosome_stability2.31143647
16MP0004957_abnormal_blastocyst_morpholog2.27962641
17MP0004185_abnormal_adipocyte_glucose2.25900140
18MP0010771_integument_phenotype2.24488142
19MP0003693_abnormal_embryo_hatching2.21643679
20MP0003011_delayed_dark_adaptation2.12571380
21MP0003186_abnormal_redox_activity2.09645674
22MP0003453_abnormal_keratinocyte_physiol1.82910390
23MP0000427_abnormal_hair_cycle1.74278942
24MP0005671_abnormal_response_to1.64686962
25MP0000467_abnormal_esophagus_morphology1.62546154
26MP0002060_abnormal_skin_morphology1.62201159
27MP0001835_abnormal_antigen_presentation1.59769459
28MP0003718_maternal_effect1.59081282
29MP0004782_abnormal_surfactant_physiolog1.58230278
30MP0002098_abnormal_vibrissa_morphology1.53707677
31MP0006036_abnormal_mitochondrial_physio1.53186968
32MP0009333_abnormal_splenocyte_physiolog1.48316992
33MP0000377_abnormal_hair_follicle1.44992923
34MP0008057_abnormal_DNA_replication1.43607951
35MP0000647_abnormal_sebaceous_gland1.38830999
36MP0008789_abnormal_olfactory_epithelium1.36715063
37MP0002095_abnormal_skin_pigmentation1.35825780
38MP0002148_abnormal_hypersensitivity_rea1.33794950
39MP0003786_premature_aging1.27900486
40MP0006072_abnormal_retinal_apoptosis1.21632129
41MP0002837_dystrophic_cardiac_calcinosis1.21094888
42MP0002254_reproductive_system_inflammat1.20020795
43MP0005379_endocrine/exocrine_gland_phen1.19466596
44MP0001853_heart_inflammation1.19022624
45MP0008877_abnormal_DNA_methylation1.15345203
46MP0006035_abnormal_mitochondrial_morpho1.07497314
47MP0003111_abnormal_nucleus_morphology1.04232078
48MP0008932_abnormal_embryonic_tissue1.03056993
49MP0009931_abnormal_skin_appearance1.02983242
50MP0001764_abnormal_homeostasis1.02350653
51MP0001191_abnormal_skin_condition1.00029741
52MP0008872_abnormal_physiological_respon0.98328000
53MP0009785_altered_susceptibility_to0.95301092
54MP0003077_abnormal_cell_cycle0.95162659
55MP0008007_abnormal_cellular_replicative0.94748882
56MP0005075_abnormal_melanosome_morpholog0.92834145
57MP0004381_abnormal_hair_follicle0.92805296
58MP0005084_abnormal_gallbladder_morpholo0.91339873
59MP0009697_abnormal_copulation0.90804713
60MP0001485_abnormal_pinna_reflex0.89736323
61MP0000685_abnormal_immune_system0.89651948
62MP0000367_abnormal_coat/_hair0.89404355
63MP0005499_abnormal_olfactory_system0.88425087
64MP0005394_taste/olfaction_phenotype0.88425087
65MP0004264_abnormal_extraembryonic_tissu0.87022284
66MP0001727_abnormal_embryo_implantation0.86703099
67MP0008875_abnormal_xenobiotic_pharmacok0.85179785
68MP0002139_abnormal_hepatobiliary_system0.83678249
69MP0003890_abnormal_embryonic-extraembry0.83581259
70MP0002006_tumorigenesis0.80553732
71MP0003191_abnormal_cellular_cholesterol0.78638811
72MP0009764_decreased_sensitivity_to0.78619427
73MP0005666_abnormal_adipose_tissue0.78010448
74MP0000358_abnormal_cell_content/0.77766377
75MP0000762_abnormal_tongue_morphology0.74688159
76MP0005636_abnormal_mineral_homeostasis0.71218842
77MP0001905_abnormal_dopamine_level0.70027020
78MP0001243_abnormal_dermal_layer0.68033367
79MP0003646_muscle_fatigue0.67879491
80MP0002234_abnormal_pharynx_morphology0.67708487
81MP0009379_abnormal_foot_pigmentation0.67149361
82MP0005387_immune_system_phenotype0.65681889
83MP0001790_abnormal_immune_system0.65681889
84MP0009053_abnormal_anal_canal0.65610956
85MP0004947_skin_inflammation0.63658731
86MP0002736_abnormal_nociception_after0.61796405
87MP0005310_abnormal_salivary_gland0.60047989
88MP0004043_abnormal_pH_regulation0.60021357
89MP0002452_abnormal_antigen_presenting0.59054665
90MP0004215_abnormal_myocardial_fiber0.58548680
91MP0000465_gastrointestinal_hemorrhage0.58317250
92MP0001529_abnormal_vocalization0.57526234
93MP0005367_renal/urinary_system_phenotyp0.56132016
94MP0000516_abnormal_urinary_system0.56132016
95MP0005000_abnormal_immune_tolerance0.53995588
96MP0001800_abnormal_humoral_immune0.53583305
97MP0004019_abnormal_vitamin_homeostasis0.52693439
98MP0005174_abnormal_tail_pigmentation0.52578991
99MP0010307_abnormal_tumor_latency0.52517830
100MP0009765_abnormal_xenobiotic_induced0.52047105

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of nail color (HP:0100643)8.44782939
2Oral leukoplakia (HP:0002745)7.33070819
3Palmoplantar hyperkeratosis (HP:0000972)6.10989888
4Erythroderma (HP:0001019)5.95222584
5Palmar hyperkeratosis (HP:0010765)5.90916077
6Onycholysis (HP:0001806)5.13159036
7Plantar hyperkeratosis (HP:0007556)5.13081849
8Congenital ichthyosiform erythroderma (HP:0007431)5.09175221
9Alopecia of scalp (HP:0002293)4.93397094
10Congenital nonbullous ichthyosiform erythroderma (HP:0007479)4.77122314
11Thick nail (HP:0001805)4.65646205
12Abnormality of the axillary hair (HP:0100134)4.64185600
13Abnormality of secondary sexual hair (HP:0009888)4.64185600
14Sparse eyelashes (HP:0000653)3.90121585
15Increased IgE level (HP:0003212)3.60729754
16Acute necrotizing encephalopathy (HP:0006965)3.55353749
17Corneal erosion (HP:0200020)3.49285032
18Parakeratosis (HP:0001036)3.33510348
19Amniotic constriction ring (HP:0009775)3.26330967
20Abnormality of placental membranes (HP:0011409)3.26330967
21Mitochondrial inheritance (HP:0001427)3.14648653
22Hypotrichosis (HP:0001006)3.13257963
23Abnormal mitochondria in muscle tissue (HP:0008316)3.11492995
24Increased CSF lactate (HP:0002490)3.08635982
25Acute encephalopathy (HP:0006846)3.06273793
26Hepatocellular necrosis (HP:0001404)2.97956312
27Hypohidrosis (HP:0000966)2.88542767
28Nail dystrophy (HP:0008404)2.86451578
29Multiple enchondromatosis (HP:0005701)2.86337885
30Progressive macrocephaly (HP:0004481)2.83238426
31Increased hepatocellular lipid droplets (HP:0006565)2.71565398
32Woolly hair (HP:0002224)2.66741159
33Erythema (HP:0010783)2.63810674
34Fragile nails (HP:0001808)2.63409728
35Lipid accumulation in hepatocytes (HP:0006561)2.62880004
36Blepharitis (HP:0000498)2.62640951
37Hepatic necrosis (HP:0002605)2.59475888
38Palmoplantar keratoderma (HP:0000982)2.58156335
39Autoamputation (HP:0001218)2.55577762
40Right ventricular cardiomyopathy (HP:0011663)2.53871611
41Ectropion (HP:0000656)2.52467224
42Gangrene (HP:0100758)2.46319708
43Absent hair (HP:0002298)2.44826860
44Sparse scalp hair (HP:0002209)2.40215887
45Increased serum lactate (HP:0002151)2.37394513
46Cerebral edema (HP:0002181)2.34559381
47Renal Fanconi syndrome (HP:0001994)2.31418966
48Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.26927077
493-Methylglutaconic aciduria (HP:0003535)2.26048160
50Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.25623403
51Decreased activity of mitochondrial respiratory chain (HP:0008972)2.25623403
52Brittle hair (HP:0002299)2.21592519
53Absent eyelashes (HP:0000561)2.21030948
54Furrowed tongue (HP:0000221)2.20732127
55Type I transferrin isoform profile (HP:0003642)2.19400536
56Respiratory failure (HP:0002878)2.18723800
57Abnormality of liposaccharide metabolism (HP:0010968)2.17974310
58Abnormality of glycosphingolipid metabolism (HP:0004343)2.17974310
59Abnormality of glycolipid metabolism (HP:0010969)2.17974310
60Lactic acidosis (HP:0003128)2.12617512
61Vacuolated lymphocytes (HP:0001922)2.06207276
62Duplicated collecting system (HP:0000081)2.05810298
63Microvesicular hepatic steatosis (HP:0001414)2.04953662
64Paralysis (HP:0003470)2.04936208
65Pili torti (HP:0003777)2.03353245
66Conjunctival hamartoma (HP:0100780)2.02220558
67Abnormal blistering of the skin (HP:0008066)2.00259321
68Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.98576619
69Exertional dyspnea (HP:0002875)1.93674196
70Urticaria (HP:0001025)1.90799122
71CNS demyelination (HP:0007305)1.90763219
72Increased serum pyruvate (HP:0003542)1.90513554
73Abnormality of the preputium (HP:0100587)1.87759185
74Palpitations (HP:0001962)1.87239952
75Clubbing of toes (HP:0100760)1.87079802
76Abnormal hair laboratory examination (HP:0003328)1.86911530
77Abnormal protein glycosylation (HP:0012346)1.83910801
78Abnormal glycosylation (HP:0012345)1.83910801
79Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.83910801
80Abnormal protein N-linked glycosylation (HP:0012347)1.83910801
81Increased intramyocellular lipid droplets (HP:0012240)1.83042158
82Reduced antithrombin III activity (HP:0001976)1.82055352
83Abnormality of alanine metabolism (HP:0010916)1.81811119
84Hyperalaninemia (HP:0003348)1.81811119
85Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.81811119
86Pruritus (HP:0000989)1.78824111
87Hyperhidrosis (HP:0000975)1.78562948
88Exercise intolerance (HP:0003546)1.72914823
89Aplastic anemia (HP:0001915)1.71161180
90Abnormality of the renal collecting system (HP:0004742)1.70973312
91Agnosia (HP:0010524)1.65703519
92Leukodystrophy (HP:0002415)1.64005087
93Optic disc pallor (HP:0000543)1.62102785
94Abnormality of glycolysis (HP:0004366)1.62069598
95Recurrent corneal erosions (HP:0000495)1.61165956
96Poor head control (HP:0002421)1.60780480
97Premature ovarian failure (HP:0008209)1.59123144
98Dry hair (HP:0011359)1.58802499
99Increased muscle lipid content (HP:0009058)1.57430442
100B lymphocytopenia (HP:0010976)1.57229183

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PBK4.12553569
2MST44.10852905
3VRK24.00050417
4EIF2AK33.43471022
5NEK13.26518649
6NME22.96177321
7TSSK62.86662977
8MAP3K122.67670378
9MAP4K22.61679134
10TGFBR12.28213363
11SRPK12.28137236
12NUAK12.25828250
13BUB12.04332463
14STK161.97264430
15EIF2AK11.93527677
16PLK41.83418645
17PDK21.80315558
18TAF11.78744143
19ZAK1.71834459
20BRSK21.66899650
21VRK11.66786172
22SCYL21.59648295
23NME11.40841584
24WEE11.37543081
25ADRBK21.28055302
26PLK31.27478396
27DAPK11.26536091
28INSRR1.25153956
29TRIM281.23517286
30MKNK21.17314974
31BCKDK1.14774051
32TIE11.11399156
33WNK31.07930745
34CDC71.07591728
35MKNK11.06378574
36BMPR1B1.04606745
37EIF2AK21.03772142
38TTK1.03641169
39WNK41.01417982
40MAPKAPK30.99408053
41ABL20.92534744
42DYRK20.89647645
43TESK10.89241471
44CSNK1G30.86584287
45PLK10.84726957
46FGFR10.83078480
47STK390.83043546
48STK38L0.81860510
49BMPR20.81184632
50IKBKB0.79510248
51PIM20.76736297
52CSNK1G10.75517178
53ACVR1B0.74303457
54KDR0.72972696
55STK240.71684875
56ATR0.70764163
57GRK10.70622897
58MYLK0.67821892
59ERBB30.67320892
60CSNK1G20.63770877
61OXSR10.61456498
62AURKB0.59725254
63PAK40.58715939
64RPS6KA40.57912694
65FER0.56403871
66STK100.56077073
67CSNK1A1L0.55547269
68MAPKAPK50.55300078
69MAP2K60.54168795
70ALK0.53805453
71TEC0.52436656
72ATM0.52022093
73PHKG10.51904339
74PHKG20.51904339
75PRKCE0.48244871
76TESK20.48019305
77BRSK10.46953330
78ILK0.46811963
79CSNK2A20.45725911
80CSNK2A10.43759516
81CHEK10.42523706
82STK30.41893258
83CHEK20.39456095
84DAPK30.39425358
85FGR0.38824956
86AURKA0.38628753
87CSNK1E0.38298897
88TRPM70.37039606
89FLT30.35803952
90MAP3K80.34934043
91PRKCI0.32626368
92LIMK10.31765945
93KIT0.31031443
94IGF1R0.30768270
95GRK70.29277294
96CSNK1A10.28469289
97MAP2K70.27883661
98PLK20.26866529
99JAK30.26862676
100ERBB40.26376205

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.90396647
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.17571697
3Oxidative phosphorylation_Homo sapiens_hsa001903.13250247
4Protein export_Homo sapiens_hsa030602.95301981
5DNA replication_Homo sapiens_hsa030302.59248539
6Asthma_Homo sapiens_hsa053102.55903357
7Parkinsons disease_Homo sapiens_hsa050122.53719844
8RNA polymerase_Homo sapiens_hsa030202.44075667
9Non-homologous end-joining_Homo sapiens_hsa034502.33241006
10Mismatch repair_Homo sapiens_hsa034302.25479336
11Fatty acid elongation_Homo sapiens_hsa000621.86045822
12Base excision repair_Homo sapiens_hsa034101.85232032
13Homologous recombination_Homo sapiens_hsa034401.82520219
14Allograft rejection_Homo sapiens_hsa053301.80965771
15Ribosome_Homo sapiens_hsa030101.80632997
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.78912151
17RNA transport_Homo sapiens_hsa030131.70326163
18Huntingtons disease_Homo sapiens_hsa050161.63329817
19One carbon pool by folate_Homo sapiens_hsa006701.60976993
20Spliceosome_Homo sapiens_hsa030401.58725533
21Alzheimers disease_Homo sapiens_hsa050101.57029010
22Type I diabetes mellitus_Homo sapiens_hsa049401.56731252
23Propanoate metabolism_Homo sapiens_hsa006401.54360421
24Autoimmune thyroid disease_Homo sapiens_hsa053201.53764407
25Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.52633949
26Sulfur metabolism_Homo sapiens_hsa009201.52552020
27RNA degradation_Homo sapiens_hsa030181.48321391
28Basal transcription factors_Homo sapiens_hsa030221.47675903
29Pyrimidine metabolism_Homo sapiens_hsa002401.47076484
30alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.46249460
31Nucleotide excision repair_Homo sapiens_hsa034201.45305407
32Intestinal immune network for IgA production_Homo sapiens_hsa046721.39271058
33Rheumatoid arthritis_Homo sapiens_hsa053231.35941067
34Ether lipid metabolism_Homo sapiens_hsa005651.34211825
35Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.33847915
36Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.27443327
37Glutathione metabolism_Homo sapiens_hsa004801.23301530
38Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.22349211
39Graft-versus-host disease_Homo sapiens_hsa053321.19598513
40Fanconi anemia pathway_Homo sapiens_hsa034601.18053762
41Collecting duct acid secretion_Homo sapiens_hsa049661.16944519
42Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.15668562
43Steroid biosynthesis_Homo sapiens_hsa001001.12400295
44Cysteine and methionine metabolism_Homo sapiens_hsa002701.12286753
45Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.11262236
46Antigen processing and presentation_Homo sapiens_hsa046121.09246017
47Linoleic acid metabolism_Homo sapiens_hsa005911.07435487
48Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.02111734
49Purine metabolism_Homo sapiens_hsa002301.01015231
50Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.00058529
51Pyruvate metabolism_Homo sapiens_hsa006200.99565883
52Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.97662253
53Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.89755493
54Folate biosynthesis_Homo sapiens_hsa007900.84919418
55Phototransduction_Homo sapiens_hsa047440.84383583
56Arachidonic acid metabolism_Homo sapiens_hsa005900.80931526
57Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.80729771
582-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.80323796
59beta-Alanine metabolism_Homo sapiens_hsa004100.76159436
60Regulation of autophagy_Homo sapiens_hsa041400.72298657
61Lysosome_Homo sapiens_hsa041420.70604808
62Carbon metabolism_Homo sapiens_hsa012000.70373425
63Cell cycle_Homo sapiens_hsa041100.68562704
64Metabolic pathways_Homo sapiens_hsa011000.68149303
65Staphylococcus aureus infection_Homo sapiens_hsa051500.68020818
66Vitamin B6 metabolism_Homo sapiens_hsa007500.62895549
67p53 signaling pathway_Homo sapiens_hsa041150.62518203
68Tryptophan metabolism_Homo sapiens_hsa003800.61949122
69SNARE interactions in vesicular transport_Homo sapiens_hsa041300.61916637
70Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.61293793
71Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.59163629
72Peroxisome_Homo sapiens_hsa041460.58937882
73Fatty acid metabolism_Homo sapiens_hsa012120.58779751
74Cardiac muscle contraction_Homo sapiens_hsa042600.58397661
75Fatty acid degradation_Homo sapiens_hsa000710.56208803
76Primary immunodeficiency_Homo sapiens_hsa053400.55838343
77Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.52298444
78Viral myocarditis_Homo sapiens_hsa054160.51716462
79Selenocompound metabolism_Homo sapiens_hsa004500.51223589
80Epstein-Barr virus infection_Homo sapiens_hsa051690.49590021
81Sphingolipid metabolism_Homo sapiens_hsa006000.48713714
82Phagosome_Homo sapiens_hsa041450.48551013
83Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.48548517
84Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.47505300
85PPAR signaling pathway_Homo sapiens_hsa033200.45981245
86Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.44799227
87mRNA surveillance pathway_Homo sapiens_hsa030150.44623859
88Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.40247588
89Drug metabolism - other enzymes_Homo sapiens_hsa009830.38689545
90Butanoate metabolism_Homo sapiens_hsa006500.32381854
91Vibrio cholerae infection_Homo sapiens_hsa051100.32031137
92Hematopoietic cell lineage_Homo sapiens_hsa046400.31536090
93Herpes simplex infection_Homo sapiens_hsa051680.31168956
94Tuberculosis_Homo sapiens_hsa051520.30476729
95Primary bile acid biosynthesis_Homo sapiens_hsa001200.24013852
96N-Glycan biosynthesis_Homo sapiens_hsa005100.23124934
97Legionellosis_Homo sapiens_hsa051340.22253315
98Glycosaminoglycan degradation_Homo sapiens_hsa005310.22016770
99Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.21698627
100Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.20967595

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