

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | keratinization (GO:0031424) | 8.10618581 |
| 2 | establishment of skin barrier (GO:0061436) | 6.57801445 |
| 3 | regulation of water loss via skin (GO:0033561) | 5.43434648 |
| 4 | keratinocyte differentiation (GO:0030216) | 5.12258741 |
| 5 | proteasome assembly (GO:0043248) | 4.65796842 |
| 6 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 4.50707810 |
| 7 | hair cycle (GO:0042633) | 4.18829628 |
| 8 | molting cycle (GO:0042303) | 4.18829628 |
| 9 | ribosome assembly (GO:0042255) | 4.09547379 |
| 10 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 4.07103463 |
| 11 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 3.97949375 |
| 12 | ATP synthesis coupled proton transport (GO:0015986) | 3.97949375 |
| 13 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.93869344 |
| 14 | epidermal cell differentiation (GO:0009913) | 3.89854549 |
| 15 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.89119354 |
| 16 | positive regulation of monocyte chemotaxis (GO:0090026) | 3.87508403 |
| 17 | desmosome organization (GO:0002934) | 3.83839625 |
| 18 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.77067374 |
| 19 | bundle of His cell to Purkinje myocyte communication (GO:0086069) | 3.67026585 |
| 20 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.64900423 |
| 21 | establishment of integrated proviral latency (GO:0075713) | 3.64187994 |
| 22 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.63183167 |
| 23 | negative regulation of ligase activity (GO:0051352) | 3.61346402 |
| 24 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.61346402 |
| 25 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.59692758 |
| 26 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.59692758 |
| 27 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.59692758 |
| 28 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.58017888 |
| 29 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.58017888 |
| 30 | respiratory chain complex IV assembly (GO:0008535) | 3.56915071 |
| 31 | maturation of 5.8S rRNA (GO:0000460) | 3.54320709 |
| 32 | DNA double-strand break processing (GO:0000729) | 3.50459191 |
| 33 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.45997225 |
| 34 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.45997225 |
| 35 | chaperone-mediated protein transport (GO:0072321) | 3.45874000 |
| 36 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.40672967 |
| 37 | protein complex biogenesis (GO:0070271) | 3.37171784 |
| 38 | peptide cross-linking (GO:0018149) | 3.35365779 |
| 39 | rRNA modification (GO:0000154) | 3.35122344 |
| 40 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.34286032 |
| 41 | DNA deamination (GO:0045006) | 3.33032254 |
| 42 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.30291964 |
| 43 | pseudouridine synthesis (GO:0001522) | 3.29683174 |
| 44 | sequestering of metal ion (GO:0051238) | 3.27994401 |
| 45 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.27191722 |
| 46 | termination of RNA polymerase III transcription (GO:0006386) | 3.27191722 |
| 47 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.23008064 |
| 48 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.22404698 |
| 49 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.22404698 |
| 50 | NADH dehydrogenase complex assembly (GO:0010257) | 3.22404698 |
| 51 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.19101939 |
| 52 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 3.19077015 |
| 53 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.17585594 |
| 54 | DNA catabolic process, exonucleolytic (GO:0000738) | 3.13018256 |
| 55 | multicellular organismal water homeostasis (GO:0050891) | 3.12987668 |
| 56 | antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590) | 3.12047574 |
| 57 | positive regulation of ligase activity (GO:0051351) | 3.09984180 |
| 58 | protein targeting to mitochondrion (GO:0006626) | 3.09470677 |
| 59 | IMP biosynthetic process (GO:0006188) | 3.09434028 |
| 60 | respiratory electron transport chain (GO:0022904) | 3.07641166 |
| 61 | keratinocyte proliferation (GO:0043616) | 3.04950135 |
| 62 | cytochrome complex assembly (GO:0017004) | 3.02990022 |
| 63 | electron transport chain (GO:0022900) | 3.01335926 |
| 64 | epidermis development (GO:0008544) | 2.99456877 |
| 65 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 2.99405574 |
| 66 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 2.99105133 |
| 67 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 2.99105133 |
| 68 | oxidative phosphorylation (GO:0006119) | 2.98480855 |
| 69 | phosphatidylinositol acyl-chain remodeling (GO:0036149) | 2.97267219 |
| 70 | viral mRNA export from host cell nucleus (GO:0046784) | 2.95743187 |
| 71 | rRNA processing (GO:0006364) | 2.94996703 |
| 72 | establishment of viral latency (GO:0019043) | 2.92643889 |
| 73 | purine nucleobase biosynthetic process (GO:0009113) | 2.92393039 |
| 74 | response to X-ray (GO:0010165) | 2.92048443 |
| 75 | regulation of mitochondrial translation (GO:0070129) | 2.91372754 |
| 76 | DNA damage response, signal transduction by p53 class mediator (GO:0030330) | 2.90527572 |
| 77 | deoxyribonucleoside triphosphate metabolic process (GO:0009200) | 2.83618875 |
| 78 | rRNA metabolic process (GO:0016072) | 2.83194243 |
| 79 | nucleobase biosynthetic process (GO:0046112) | 2.81013140 |
| 80 | protein localization to mitochondrion (GO:0070585) | 2.80101474 |
| 81 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 2.79782749 |
| 82 | positive regulation of cell cycle arrest (GO:0071158) | 2.79206108 |
| 83 | establishment of protein localization to mitochondrion (GO:0072655) | 2.78836792 |
| 84 | negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class | 2.78348930 |
| 85 | regulation of cellular amine metabolic process (GO:0033238) | 2.75940254 |
| 86 | rRNA methylation (GO:0031167) | 2.75028428 |
| 87 | ribosomal large subunit biogenesis (GO:0042273) | 2.71814224 |
| 88 | platelet dense granule organization (GO:0060155) | 2.71547318 |
| 89 | regulation of ligase activity (GO:0051340) | 2.70726236 |
| 90 | ribosome biogenesis (GO:0042254) | 2.70502383 |
| 91 | IMP metabolic process (GO:0046040) | 2.70230896 |
| 92 | negative regulation of inflammatory response to antigenic stimulus (GO:0002862) | 2.70213799 |
| 93 | cullin deneddylation (GO:0010388) | 2.70212476 |
| 94 | RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503) | 2.68467230 |
| 95 | negative regulation of protein ubiquitination (GO:0031397) | 2.66270627 |
| 96 | intermediate filament organization (GO:0045109) | 2.64929408 |
| 97 | protein maturation by protein folding (GO:0022417) | 2.64389720 |
| 98 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 2.64330301 |
| 99 | phosphatidylserine acyl-chain remodeling (GO:0036150) | 2.64278164 |
| 100 | non-recombinational repair (GO:0000726) | 2.62795128 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 5.41006337 |
| 2 | E2F7_22180533_ChIP-Seq_HELA_Human | 4.75882127 |
| 3 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.45122035 |
| 4 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.86309526 |
| 5 | TP63_17297297_ChIP-ChIP_HaCaT_Human | 3.79648724 |
| 6 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 3.60366764 |
| 7 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.47775707 |
| 8 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 3.34102818 |
| 9 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 3.33347960 |
| 10 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.13584692 |
| 11 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.79777451 |
| 12 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 2.78123376 |
| 13 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.66295794 |
| 14 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.54938278 |
| 15 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 2.52046025 |
| 16 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.43100062 |
| 17 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.41582430 |
| 18 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.40159455 |
| 19 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.33702121 |
| 20 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.33127484 |
| 21 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.29446976 |
| 22 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.16465412 |
| 23 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.15787557 |
| 24 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 2.02590876 |
| 25 | DCP1A_22483619_ChIP-Seq_HELA_Human | 2.01692023 |
| 26 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.95341223 |
| 27 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 1.86296092 |
| 28 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.81389653 |
| 29 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.73201231 |
| 30 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 1.71798513 |
| 31 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.70754009 |
| 32 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.68826009 |
| 33 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.67028562 |
| 34 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 1.62899468 |
| 35 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.61919489 |
| 36 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 1.56065574 |
| 37 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.54698826 |
| 38 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.52153338 |
| 39 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.51134007 |
| 40 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.48778219 |
| 41 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.48440993 |
| 42 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.43262636 |
| 43 | SMAD4_19686287_ChIP-ChIP_HaCaT_Human | 1.43072437 |
| 44 | HTT_18923047_ChIP-ChIP_STHdh_Human | 1.38420593 |
| 45 | VDR_22108803_ChIP-Seq_LS180_Human | 1.38187312 |
| 46 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.36525055 |
| 47 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 1.34686749 |
| 48 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.28077933 |
| 49 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.27272532 |
| 50 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 1.26971369 |
| 51 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.25553628 |
| 52 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.24594618 |
| 53 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.23888752 |
| 54 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.21259417 |
| 55 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.20649360 |
| 56 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.20550130 |
| 57 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.19022887 |
| 58 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.14189807 |
| 59 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.13009411 |
| 60 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 1.12789779 |
| 61 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.10541011 |
| 62 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.10437850 |
| 63 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.10385473 |
| 64 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.06542928 |
| 65 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.04999198 |
| 66 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 1.04570894 |
| 67 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.02410882 |
| 68 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.02115279 |
| 69 | ELF5_23300383_ChIP-Seq_T47D_Human | 0.99433077 |
| 70 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 0.99304551 |
| 71 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 0.98030802 |
| 72 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.96407758 |
| 73 | XRN2_22483619_ChIP-Seq_HELA_Human | 0.95235825 |
| 74 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 0.95023099 |
| 75 | ERG_20517297_ChIP-Seq_VCAP_Human | 0.94970840 |
| 76 | TFEB_21752829_ChIP-Seq_HELA_Human | 0.94417041 |
| 77 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 0.91603924 |
| 78 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.91139768 |
| 79 | SPI1_23547873_ChIP-Seq_NB4_Human | 0.89843609 |
| 80 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 0.88775034 |
| 81 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 0.87387079 |
| 82 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 0.86803577 |
| 83 | EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human | 0.84613330 |
| 84 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 0.84156228 |
| 85 | GATA6_21074721_ChIP-Seq_CACO-2_Mouse | 0.83828356 |
| 86 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 0.83495939 |
| 87 | STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse | 0.83174366 |
| 88 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 0.81707867 |
| 89 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.81285141 |
| 90 | EWS_26573619_Chip-Seq_HEK293_Human | 0.81106351 |
| 91 | RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse | 0.80785094 |
| 92 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 0.80052019 |
| 93 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 0.80052019 |
| 94 | AR_20517297_ChIP-Seq_VCAP_Human | 0.78926144 |
| 95 | RBPJ_21746931_ChIP-Seq_IB4_Human | 0.78395544 |
| 96 | NCOR_22424771_ChIP-Seq_293T_Human | 0.77475503 |
| 97 | PPARD_23208498_ChIP-Seq_MDA-MB-231_Human | 0.77361649 |
| 98 | GATA3_26560356_Chip-Seq_TH2_Human | 0.77310439 |
| 99 | CEBPA_26348894_ChIP-Seq_LIVER_Mouse | 0.76165785 |
| 100 | GATA6_21074721_ChIP-Seq_CACO-2_Human | 0.75657400 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0002796_impaired_skin_barrier | 7.46076988 |
| 2 | MP0000579_abnormal_nail_morphology | 4.31261459 |
| 3 | MP0005501_abnormal_skin_physiology | 4.15005114 |
| 4 | MP0003806_abnormal_nucleotide_metabolis | 3.66499704 |
| 5 | MP0010234_abnormal_vibrissa_follicle | 3.60434639 |
| 6 | MP0005275_abnormal_skin_tensile | 2.97060884 |
| 7 | MP0004885_abnormal_endolymph | 2.76554055 |
| 8 | MP0001216_abnormal_epidermal_layer | 2.71110449 |
| 9 | MP0005377_hearing/vestibular/ear_phenot | 2.69605715 |
| 10 | MP0003878_abnormal_ear_physiology | 2.69605715 |
| 11 | MP0003941_abnormal_skin_development | 2.64948524 |
| 12 | MP0010678_abnormal_skin_adnexa | 2.47760958 |
| 13 | MP0008058_abnormal_DNA_repair | 2.46835804 |
| 14 | MP0000383_abnormal_hair_follicle | 2.32784115 |
| 15 | MP0010094_abnormal_chromosome_stability | 2.31143647 |
| 16 | MP0004957_abnormal_blastocyst_morpholog | 2.27962641 |
| 17 | MP0004185_abnormal_adipocyte_glucose | 2.25900140 |
| 18 | MP0010771_integument_phenotype | 2.24488142 |
| 19 | MP0003693_abnormal_embryo_hatching | 2.21643679 |
| 20 | MP0003011_delayed_dark_adaptation | 2.12571380 |
| 21 | MP0003186_abnormal_redox_activity | 2.09645674 |
| 22 | MP0003453_abnormal_keratinocyte_physiol | 1.82910390 |
| 23 | MP0000427_abnormal_hair_cycle | 1.74278942 |
| 24 | MP0005671_abnormal_response_to | 1.64686962 |
| 25 | MP0000467_abnormal_esophagus_morphology | 1.62546154 |
| 26 | MP0002060_abnormal_skin_morphology | 1.62201159 |
| 27 | MP0001835_abnormal_antigen_presentation | 1.59769459 |
| 28 | MP0003718_maternal_effect | 1.59081282 |
| 29 | MP0004782_abnormal_surfactant_physiolog | 1.58230278 |
| 30 | MP0002098_abnormal_vibrissa_morphology | 1.53707677 |
| 31 | MP0006036_abnormal_mitochondrial_physio | 1.53186968 |
| 32 | MP0009333_abnormal_splenocyte_physiolog | 1.48316992 |
| 33 | MP0000377_abnormal_hair_follicle | 1.44992923 |
| 34 | MP0008057_abnormal_DNA_replication | 1.43607951 |
| 35 | MP0000647_abnormal_sebaceous_gland | 1.38830999 |
| 36 | MP0008789_abnormal_olfactory_epithelium | 1.36715063 |
| 37 | MP0002095_abnormal_skin_pigmentation | 1.35825780 |
| 38 | MP0002148_abnormal_hypersensitivity_rea | 1.33794950 |
| 39 | MP0003786_premature_aging | 1.27900486 |
| 40 | MP0006072_abnormal_retinal_apoptosis | 1.21632129 |
| 41 | MP0002837_dystrophic_cardiac_calcinosis | 1.21094888 |
| 42 | MP0002254_reproductive_system_inflammat | 1.20020795 |
| 43 | MP0005379_endocrine/exocrine_gland_phen | 1.19466596 |
| 44 | MP0001853_heart_inflammation | 1.19022624 |
| 45 | MP0008877_abnormal_DNA_methylation | 1.15345203 |
| 46 | MP0006035_abnormal_mitochondrial_morpho | 1.07497314 |
| 47 | MP0003111_abnormal_nucleus_morphology | 1.04232078 |
| 48 | MP0008932_abnormal_embryonic_tissue | 1.03056993 |
| 49 | MP0009931_abnormal_skin_appearance | 1.02983242 |
| 50 | MP0001764_abnormal_homeostasis | 1.02350653 |
| 51 | MP0001191_abnormal_skin_condition | 1.00029741 |
| 52 | MP0008872_abnormal_physiological_respon | 0.98328000 |
| 53 | MP0009785_altered_susceptibility_to | 0.95301092 |
| 54 | MP0003077_abnormal_cell_cycle | 0.95162659 |
| 55 | MP0008007_abnormal_cellular_replicative | 0.94748882 |
| 56 | MP0005075_abnormal_melanosome_morpholog | 0.92834145 |
| 57 | MP0004381_abnormal_hair_follicle | 0.92805296 |
| 58 | MP0005084_abnormal_gallbladder_morpholo | 0.91339873 |
| 59 | MP0009697_abnormal_copulation | 0.90804713 |
| 60 | MP0001485_abnormal_pinna_reflex | 0.89736323 |
| 61 | MP0000685_abnormal_immune_system | 0.89651948 |
| 62 | MP0000367_abnormal_coat/_hair | 0.89404355 |
| 63 | MP0005499_abnormal_olfactory_system | 0.88425087 |
| 64 | MP0005394_taste/olfaction_phenotype | 0.88425087 |
| 65 | MP0004264_abnormal_extraembryonic_tissu | 0.87022284 |
| 66 | MP0001727_abnormal_embryo_implantation | 0.86703099 |
| 67 | MP0008875_abnormal_xenobiotic_pharmacok | 0.85179785 |
| 68 | MP0002139_abnormal_hepatobiliary_system | 0.83678249 |
| 69 | MP0003890_abnormal_embryonic-extraembry | 0.83581259 |
| 70 | MP0002006_tumorigenesis | 0.80553732 |
| 71 | MP0003191_abnormal_cellular_cholesterol | 0.78638811 |
| 72 | MP0009764_decreased_sensitivity_to | 0.78619427 |
| 73 | MP0005666_abnormal_adipose_tissue | 0.78010448 |
| 74 | MP0000358_abnormal_cell_content/ | 0.77766377 |
| 75 | MP0000762_abnormal_tongue_morphology | 0.74688159 |
| 76 | MP0005636_abnormal_mineral_homeostasis | 0.71218842 |
| 77 | MP0001905_abnormal_dopamine_level | 0.70027020 |
| 78 | MP0001243_abnormal_dermal_layer | 0.68033367 |
| 79 | MP0003646_muscle_fatigue | 0.67879491 |
| 80 | MP0002234_abnormal_pharynx_morphology | 0.67708487 |
| 81 | MP0009379_abnormal_foot_pigmentation | 0.67149361 |
| 82 | MP0005387_immune_system_phenotype | 0.65681889 |
| 83 | MP0001790_abnormal_immune_system | 0.65681889 |
| 84 | MP0009053_abnormal_anal_canal | 0.65610956 |
| 85 | MP0004947_skin_inflammation | 0.63658731 |
| 86 | MP0002736_abnormal_nociception_after | 0.61796405 |
| 87 | MP0005310_abnormal_salivary_gland | 0.60047989 |
| 88 | MP0004043_abnormal_pH_regulation | 0.60021357 |
| 89 | MP0002452_abnormal_antigen_presenting | 0.59054665 |
| 90 | MP0004215_abnormal_myocardial_fiber | 0.58548680 |
| 91 | MP0000465_gastrointestinal_hemorrhage | 0.58317250 |
| 92 | MP0001529_abnormal_vocalization | 0.57526234 |
| 93 | MP0005367_renal/urinary_system_phenotyp | 0.56132016 |
| 94 | MP0000516_abnormal_urinary_system | 0.56132016 |
| 95 | MP0005000_abnormal_immune_tolerance | 0.53995588 |
| 96 | MP0001800_abnormal_humoral_immune | 0.53583305 |
| 97 | MP0004019_abnormal_vitamin_homeostasis | 0.52693439 |
| 98 | MP0005174_abnormal_tail_pigmentation | 0.52578991 |
| 99 | MP0010307_abnormal_tumor_latency | 0.52517830 |
| 100 | MP0009765_abnormal_xenobiotic_induced | 0.52047105 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Abnormality of nail color (HP:0100643) | 8.44782939 |
| 2 | Oral leukoplakia (HP:0002745) | 7.33070819 |
| 3 | Palmoplantar hyperkeratosis (HP:0000972) | 6.10989888 |
| 4 | Erythroderma (HP:0001019) | 5.95222584 |
| 5 | Palmar hyperkeratosis (HP:0010765) | 5.90916077 |
| 6 | Onycholysis (HP:0001806) | 5.13159036 |
| 7 | Plantar hyperkeratosis (HP:0007556) | 5.13081849 |
| 8 | Congenital ichthyosiform erythroderma (HP:0007431) | 5.09175221 |
| 9 | Alopecia of scalp (HP:0002293) | 4.93397094 |
| 10 | Congenital nonbullous ichthyosiform erythroderma (HP:0007479) | 4.77122314 |
| 11 | Thick nail (HP:0001805) | 4.65646205 |
| 12 | Abnormality of the axillary hair (HP:0100134) | 4.64185600 |
| 13 | Abnormality of secondary sexual hair (HP:0009888) | 4.64185600 |
| 14 | Sparse eyelashes (HP:0000653) | 3.90121585 |
| 15 | Increased IgE level (HP:0003212) | 3.60729754 |
| 16 | Acute necrotizing encephalopathy (HP:0006965) | 3.55353749 |
| 17 | Corneal erosion (HP:0200020) | 3.49285032 |
| 18 | Parakeratosis (HP:0001036) | 3.33510348 |
| 19 | Amniotic constriction ring (HP:0009775) | 3.26330967 |
| 20 | Abnormality of placental membranes (HP:0011409) | 3.26330967 |
| 21 | Mitochondrial inheritance (HP:0001427) | 3.14648653 |
| 22 | Hypotrichosis (HP:0001006) | 3.13257963 |
| 23 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.11492995 |
| 24 | Increased CSF lactate (HP:0002490) | 3.08635982 |
| 25 | Acute encephalopathy (HP:0006846) | 3.06273793 |
| 26 | Hepatocellular necrosis (HP:0001404) | 2.97956312 |
| 27 | Hypohidrosis (HP:0000966) | 2.88542767 |
| 28 | Nail dystrophy (HP:0008404) | 2.86451578 |
| 29 | Multiple enchondromatosis (HP:0005701) | 2.86337885 |
| 30 | Progressive macrocephaly (HP:0004481) | 2.83238426 |
| 31 | Increased hepatocellular lipid droplets (HP:0006565) | 2.71565398 |
| 32 | Woolly hair (HP:0002224) | 2.66741159 |
| 33 | Erythema (HP:0010783) | 2.63810674 |
| 34 | Fragile nails (HP:0001808) | 2.63409728 |
| 35 | Lipid accumulation in hepatocytes (HP:0006561) | 2.62880004 |
| 36 | Blepharitis (HP:0000498) | 2.62640951 |
| 37 | Hepatic necrosis (HP:0002605) | 2.59475888 |
| 38 | Palmoplantar keratoderma (HP:0000982) | 2.58156335 |
| 39 | Autoamputation (HP:0001218) | 2.55577762 |
| 40 | Right ventricular cardiomyopathy (HP:0011663) | 2.53871611 |
| 41 | Ectropion (HP:0000656) | 2.52467224 |
| 42 | Gangrene (HP:0100758) | 2.46319708 |
| 43 | Absent hair (HP:0002298) | 2.44826860 |
| 44 | Sparse scalp hair (HP:0002209) | 2.40215887 |
| 45 | Increased serum lactate (HP:0002151) | 2.37394513 |
| 46 | Cerebral edema (HP:0002181) | 2.34559381 |
| 47 | Renal Fanconi syndrome (HP:0001994) | 2.31418966 |
| 48 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.26927077 |
| 49 | 3-Methylglutaconic aciduria (HP:0003535) | 2.26048160 |
| 50 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 2.25623403 |
| 51 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 2.25623403 |
| 52 | Brittle hair (HP:0002299) | 2.21592519 |
| 53 | Absent eyelashes (HP:0000561) | 2.21030948 |
| 54 | Furrowed tongue (HP:0000221) | 2.20732127 |
| 55 | Type I transferrin isoform profile (HP:0003642) | 2.19400536 |
| 56 | Respiratory failure (HP:0002878) | 2.18723800 |
| 57 | Abnormality of liposaccharide metabolism (HP:0010968) | 2.17974310 |
| 58 | Abnormality of glycosphingolipid metabolism (HP:0004343) | 2.17974310 |
| 59 | Abnormality of glycolipid metabolism (HP:0010969) | 2.17974310 |
| 60 | Lactic acidosis (HP:0003128) | 2.12617512 |
| 61 | Vacuolated lymphocytes (HP:0001922) | 2.06207276 |
| 62 | Duplicated collecting system (HP:0000081) | 2.05810298 |
| 63 | Microvesicular hepatic steatosis (HP:0001414) | 2.04953662 |
| 64 | Paralysis (HP:0003470) | 2.04936208 |
| 65 | Pili torti (HP:0003777) | 2.03353245 |
| 66 | Conjunctival hamartoma (HP:0100780) | 2.02220558 |
| 67 | Abnormal blistering of the skin (HP:0008066) | 2.00259321 |
| 68 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 1.98576619 |
| 69 | Exertional dyspnea (HP:0002875) | 1.93674196 |
| 70 | Urticaria (HP:0001025) | 1.90799122 |
| 71 | CNS demyelination (HP:0007305) | 1.90763219 |
| 72 | Increased serum pyruvate (HP:0003542) | 1.90513554 |
| 73 | Abnormality of the preputium (HP:0100587) | 1.87759185 |
| 74 | Palpitations (HP:0001962) | 1.87239952 |
| 75 | Clubbing of toes (HP:0100760) | 1.87079802 |
| 76 | Abnormal hair laboratory examination (HP:0003328) | 1.86911530 |
| 77 | Abnormal protein glycosylation (HP:0012346) | 1.83910801 |
| 78 | Abnormal glycosylation (HP:0012345) | 1.83910801 |
| 79 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 1.83910801 |
| 80 | Abnormal protein N-linked glycosylation (HP:0012347) | 1.83910801 |
| 81 | Increased intramyocellular lipid droplets (HP:0012240) | 1.83042158 |
| 82 | Reduced antithrombin III activity (HP:0001976) | 1.82055352 |
| 83 | Abnormality of alanine metabolism (HP:0010916) | 1.81811119 |
| 84 | Hyperalaninemia (HP:0003348) | 1.81811119 |
| 85 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 1.81811119 |
| 86 | Pruritus (HP:0000989) | 1.78824111 |
| 87 | Hyperhidrosis (HP:0000975) | 1.78562948 |
| 88 | Exercise intolerance (HP:0003546) | 1.72914823 |
| 89 | Aplastic anemia (HP:0001915) | 1.71161180 |
| 90 | Abnormality of the renal collecting system (HP:0004742) | 1.70973312 |
| 91 | Agnosia (HP:0010524) | 1.65703519 |
| 92 | Leukodystrophy (HP:0002415) | 1.64005087 |
| 93 | Optic disc pallor (HP:0000543) | 1.62102785 |
| 94 | Abnormality of glycolysis (HP:0004366) | 1.62069598 |
| 95 | Recurrent corneal erosions (HP:0000495) | 1.61165956 |
| 96 | Poor head control (HP:0002421) | 1.60780480 |
| 97 | Premature ovarian failure (HP:0008209) | 1.59123144 |
| 98 | Dry hair (HP:0011359) | 1.58802499 |
| 99 | Increased muscle lipid content (HP:0009058) | 1.57430442 |
| 100 | B lymphocytopenia (HP:0010976) | 1.57229183 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | PBK | 4.12553569 |
| 2 | MST4 | 4.10852905 |
| 3 | VRK2 | 4.00050417 |
| 4 | EIF2AK3 | 3.43471022 |
| 5 | NEK1 | 3.26518649 |
| 6 | NME2 | 2.96177321 |
| 7 | TSSK6 | 2.86662977 |
| 8 | MAP3K12 | 2.67670378 |
| 9 | MAP4K2 | 2.61679134 |
| 10 | TGFBR1 | 2.28213363 |
| 11 | SRPK1 | 2.28137236 |
| 12 | NUAK1 | 2.25828250 |
| 13 | BUB1 | 2.04332463 |
| 14 | STK16 | 1.97264430 |
| 15 | EIF2AK1 | 1.93527677 |
| 16 | PLK4 | 1.83418645 |
| 17 | PDK2 | 1.80315558 |
| 18 | TAF1 | 1.78744143 |
| 19 | ZAK | 1.71834459 |
| 20 | BRSK2 | 1.66899650 |
| 21 | VRK1 | 1.66786172 |
| 22 | SCYL2 | 1.59648295 |
| 23 | NME1 | 1.40841584 |
| 24 | WEE1 | 1.37543081 |
| 25 | ADRBK2 | 1.28055302 |
| 26 | PLK3 | 1.27478396 |
| 27 | DAPK1 | 1.26536091 |
| 28 | INSRR | 1.25153956 |
| 29 | TRIM28 | 1.23517286 |
| 30 | MKNK2 | 1.17314974 |
| 31 | BCKDK | 1.14774051 |
| 32 | TIE1 | 1.11399156 |
| 33 | WNK3 | 1.07930745 |
| 34 | CDC7 | 1.07591728 |
| 35 | MKNK1 | 1.06378574 |
| 36 | BMPR1B | 1.04606745 |
| 37 | EIF2AK2 | 1.03772142 |
| 38 | TTK | 1.03641169 |
| 39 | WNK4 | 1.01417982 |
| 40 | MAPKAPK3 | 0.99408053 |
| 41 | ABL2 | 0.92534744 |
| 42 | DYRK2 | 0.89647645 |
| 43 | TESK1 | 0.89241471 |
| 44 | CSNK1G3 | 0.86584287 |
| 45 | PLK1 | 0.84726957 |
| 46 | FGFR1 | 0.83078480 |
| 47 | STK39 | 0.83043546 |
| 48 | STK38L | 0.81860510 |
| 49 | BMPR2 | 0.81184632 |
| 50 | IKBKB | 0.79510248 |
| 51 | PIM2 | 0.76736297 |
| 52 | CSNK1G1 | 0.75517178 |
| 53 | ACVR1B | 0.74303457 |
| 54 | KDR | 0.72972696 |
| 55 | STK24 | 0.71684875 |
| 56 | ATR | 0.70764163 |
| 57 | GRK1 | 0.70622897 |
| 58 | MYLK | 0.67821892 |
| 59 | ERBB3 | 0.67320892 |
| 60 | CSNK1G2 | 0.63770877 |
| 61 | OXSR1 | 0.61456498 |
| 62 | AURKB | 0.59725254 |
| 63 | PAK4 | 0.58715939 |
| 64 | RPS6KA4 | 0.57912694 |
| 65 | FER | 0.56403871 |
| 66 | STK10 | 0.56077073 |
| 67 | CSNK1A1L | 0.55547269 |
| 68 | MAPKAPK5 | 0.55300078 |
| 69 | MAP2K6 | 0.54168795 |
| 70 | ALK | 0.53805453 |
| 71 | TEC | 0.52436656 |
| 72 | ATM | 0.52022093 |
| 73 | PHKG1 | 0.51904339 |
| 74 | PHKG2 | 0.51904339 |
| 75 | PRKCE | 0.48244871 |
| 76 | TESK2 | 0.48019305 |
| 77 | BRSK1 | 0.46953330 |
| 78 | ILK | 0.46811963 |
| 79 | CSNK2A2 | 0.45725911 |
| 80 | CSNK2A1 | 0.43759516 |
| 81 | CHEK1 | 0.42523706 |
| 82 | STK3 | 0.41893258 |
| 83 | CHEK2 | 0.39456095 |
| 84 | DAPK3 | 0.39425358 |
| 85 | FGR | 0.38824956 |
| 86 | AURKA | 0.38628753 |
| 87 | CSNK1E | 0.38298897 |
| 88 | TRPM7 | 0.37039606 |
| 89 | FLT3 | 0.35803952 |
| 90 | MAP3K8 | 0.34934043 |
| 91 | PRKCI | 0.32626368 |
| 92 | LIMK1 | 0.31765945 |
| 93 | KIT | 0.31031443 |
| 94 | IGF1R | 0.30768270 |
| 95 | GRK7 | 0.29277294 |
| 96 | CSNK1A1 | 0.28469289 |
| 97 | MAP2K7 | 0.27883661 |
| 98 | PLK2 | 0.26866529 |
| 99 | JAK3 | 0.26862676 |
| 100 | ERBB4 | 0.26376205 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 4.90396647 |
| 2 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 3.17571697 |
| 3 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 3.13250247 |
| 4 | Protein export_Homo sapiens_hsa03060 | 2.95301981 |
| 5 | DNA replication_Homo sapiens_hsa03030 | 2.59248539 |
| 6 | Asthma_Homo sapiens_hsa05310 | 2.55903357 |
| 7 | Parkinsons disease_Homo sapiens_hsa05012 | 2.53719844 |
| 8 | RNA polymerase_Homo sapiens_hsa03020 | 2.44075667 |
| 9 | Non-homologous end-joining_Homo sapiens_hsa03450 | 2.33241006 |
| 10 | Mismatch repair_Homo sapiens_hsa03430 | 2.25479336 |
| 11 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.86045822 |
| 12 | Base excision repair_Homo sapiens_hsa03410 | 1.85232032 |
| 13 | Homologous recombination_Homo sapiens_hsa03440 | 1.82520219 |
| 14 | Allograft rejection_Homo sapiens_hsa05330 | 1.80965771 |
| 15 | Ribosome_Homo sapiens_hsa03010 | 1.80632997 |
| 16 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.78912151 |
| 17 | RNA transport_Homo sapiens_hsa03013 | 1.70326163 |
| 18 | Huntingtons disease_Homo sapiens_hsa05016 | 1.63329817 |
| 19 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.60976993 |
| 20 | Spliceosome_Homo sapiens_hsa03040 | 1.58725533 |
| 21 | Alzheimers disease_Homo sapiens_hsa05010 | 1.57029010 |
| 22 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 1.56731252 |
| 23 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.54360421 |
| 24 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 1.53764407 |
| 25 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.52633949 |
| 26 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.52552020 |
| 27 | RNA degradation_Homo sapiens_hsa03018 | 1.48321391 |
| 28 | Basal transcription factors_Homo sapiens_hsa03022 | 1.47675903 |
| 29 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.47076484 |
| 30 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 1.46249460 |
| 31 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.45305407 |
| 32 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 1.39271058 |
| 33 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 1.35941067 |
| 34 | Ether lipid metabolism_Homo sapiens_hsa00565 | 1.34211825 |
| 35 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 1.33847915 |
| 36 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.27443327 |
| 37 | Glutathione metabolism_Homo sapiens_hsa00480 | 1.23301530 |
| 38 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.22349211 |
| 39 | Graft-versus-host disease_Homo sapiens_hsa05332 | 1.19598513 |
| 40 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.18053762 |
| 41 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 1.16944519 |
| 42 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.15668562 |
| 43 | Steroid biosynthesis_Homo sapiens_hsa00100 | 1.12400295 |
| 44 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.12286753 |
| 45 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.11262236 |
| 46 | Antigen processing and presentation_Homo sapiens_hsa04612 | 1.09246017 |
| 47 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 1.07435487 |
| 48 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.02111734 |
| 49 | Purine metabolism_Homo sapiens_hsa00230 | 1.01015231 |
| 50 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 1.00058529 |
| 51 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.99565883 |
| 52 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.97662253 |
| 53 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.89755493 |
| 54 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.84919418 |
| 55 | Phototransduction_Homo sapiens_hsa04744 | 0.84383583 |
| 56 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.80931526 |
| 57 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.80729771 |
| 58 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.80323796 |
| 59 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.76159436 |
| 60 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.72298657 |
| 61 | Lysosome_Homo sapiens_hsa04142 | 0.70604808 |
| 62 | Carbon metabolism_Homo sapiens_hsa01200 | 0.70373425 |
| 63 | Cell cycle_Homo sapiens_hsa04110 | 0.68562704 |
| 64 | Metabolic pathways_Homo sapiens_hsa01100 | 0.68149303 |
| 65 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 0.68020818 |
| 66 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.62895549 |
| 67 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.62518203 |
| 68 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.61949122 |
| 69 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.61916637 |
| 70 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.61293793 |
| 71 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.59163629 |
| 72 | Peroxisome_Homo sapiens_hsa04146 | 0.58937882 |
| 73 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.58779751 |
| 74 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.58397661 |
| 75 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.56208803 |
| 76 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.55838343 |
| 77 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.52298444 |
| 78 | Viral myocarditis_Homo sapiens_hsa05416 | 0.51716462 |
| 79 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.51223589 |
| 80 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.49590021 |
| 81 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.48713714 |
| 82 | Phagosome_Homo sapiens_hsa04145 | 0.48551013 |
| 83 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.48548517 |
| 84 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.47505300 |
| 85 | PPAR signaling pathway_Homo sapiens_hsa03320 | 0.45981245 |
| 86 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.44799227 |
| 87 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.44623859 |
| 88 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.40247588 |
| 89 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.38689545 |
| 90 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.32381854 |
| 91 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.32031137 |
| 92 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.31536090 |
| 93 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.31168956 |
| 94 | Tuberculosis_Homo sapiens_hsa05152 | 0.30476729 |
| 95 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.24013852 |
| 96 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.23124934 |
| 97 | Legionellosis_Homo sapiens_hsa05134 | 0.22253315 |
| 98 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 0.22016770 |
| 99 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.21698627 |
| 100 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.20967595 |

