FABP6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the ileal fatty acid binding protein. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. FABP6 and FABP1 (the liver fatty acid binding protein) are also able to bind bile acids. It is thought that FABPs roles include fatty acid uptake, transport, and metabolism. Transcript variants generated by alternate transcription promoters and/or alternate splicing have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1lipoprotein transport (GO:0042953)8.65199475
2positive regulation of macrophage derived foam cell differentiation (GO:0010744)8.33723958
3intestinal epithelial cell development (GO:0060576)8.10114275
4regulation of guanylate cyclase activity (GO:0031282)7.92794796
5regulation of glucose import in response to insulin stimulus (GO:2001273)7.31310951
6lung secretory cell differentiation (GO:0061140)7.27527529
7* bile acid and bile salt transport (GO:0015721)7.23561527
8epoxygenase P450 pathway (GO:0019373)7.21519030
9phosphatidylinositol acyl-chain remodeling (GO:0036149)7.14214083
10NADH metabolic process (GO:0006734)7.08258500
11fat-soluble vitamin biosynthetic process (GO:0042362)6.86615434
12phosphatidylserine acyl-chain remodeling (GO:0036150)6.72130344
13maintenance of gastrointestinal epithelium (GO:0030277)6.54779587
14positive regulation of guanylate cyclase activity (GO:0031284)6.52216385
15intestinal absorption (GO:0050892)6.42218761
16hepatocyte apoptotic process (GO:0097284)6.40348441
17regulation of bile acid biosynthetic process (GO:0070857)6.15902828
18intestinal cholesterol absorption (GO:0030299)6.14909514
19angiotensin maturation (GO:0002003)6.13473506
20positive regulation of cellular response to insulin stimulus (GO:1900078)6.10335578
21protein-lipid complex remodeling (GO:0034368)6.10012167
22macromolecular complex remodeling (GO:0034367)6.10012167
23plasma lipoprotein particle remodeling (GO:0034369)6.10012167
24phosphatidylglycerol acyl-chain remodeling (GO:0036148)5.86222836
25regulation of norepinephrine secretion (GO:0014061)5.81219625
26fructose metabolic process (GO:0006000)5.64732356
27sulfation (GO:0051923)5.59873154
28regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)5.47739597
29endocrine process (GO:0050886)5.47739597
30regulation of systemic arterial blood pressure by hormone (GO:0001990)5.47739597
31hormone catabolic process (GO:0042447)5.43126830
32cellular glucuronidation (GO:0052695)5.42762552
33regulation of triglyceride catabolic process (GO:0010896)5.38914030
34glucuronate metabolic process (GO:0019585)5.33509185
35uronic acid metabolic process (GO:0006063)5.33509185
36phosphatidylethanolamine acyl-chain remodeling (GO:0036152)5.16757438
37glandular epithelial cell differentiation (GO:0002067)5.13179830
38drug metabolic process (GO:0017144)5.08358183
39epithelial structure maintenance (GO:0010669)4.95412039
40regulation of cellular extravasation (GO:0002691)4.93093338
41regulation of systemic arterial blood pressure (GO:0003073)4.88949496
42bundle of His cell to Purkinje myocyte communication (GO:0086069)4.88014873
43phosphatidylserine metabolic process (GO:0006658)4.84938135
44regulation of cGMP biosynthetic process (GO:0030826)4.83412392
45regulation of macrophage derived foam cell differentiation (GO:0010743)4.81885519
46plasma lipoprotein particle organization (GO:0071827)4.78443121
47urea cycle (GO:0000050)4.75743219
48protein-lipid complex subunit organization (GO:0071825)4.72406186
49very-low-density lipoprotein particle assembly (GO:0034379)4.68449664
50peptide hormone processing (GO:0016486)4.63912013
51pyrimidine-containing compound transmembrane transport (GO:0072531)4.55988314
52flavonoid metabolic process (GO:0009812)4.54753812
53glycolipid catabolic process (GO:0019377)4.51762510
54urea metabolic process (GO:0019627)4.51132398
55regulation of cytokine secretion involved in immune response (GO:0002739)4.50464639
56glycosphingolipid catabolic process (GO:0046479)4.45676590
57receptor guanylyl cyclase signaling pathway (GO:0007168)4.42248885
58phosphatidylcholine acyl-chain remodeling (GO:0036151)4.36639947
59digestive system process (GO:0022600)4.30858231
60calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)4.30228449
61mucosal immune response (GO:0002385)4.26502358
62plasma lipoprotein particle assembly (GO:0034377)4.25056012
63regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)4.20471017
64virion attachment to host cell (GO:0019062)4.20080192
65adhesion of symbiont to host cell (GO:0044650)4.20080192
66nitrogen cycle metabolic process (GO:0071941)4.16735587
67negative regulation of cell fate commitment (GO:0010454)4.11232797
68regulation of vitamin metabolic process (GO:0030656)4.10050451
69actin filament depolymerization (GO:0030042)4.06482640
70vitamin transmembrane transport (GO:0035461)4.06425574
71fat-soluble vitamin metabolic process (GO:0006775)4.05867514
72alditol phosphate metabolic process (GO:0052646)4.03848254
73organ or tissue specific immune response (GO:0002251)4.03727258
74regulation of cGMP metabolic process (GO:0030823)4.01713041
75mRNA modification (GO:0016556)4.01322423
76peptide catabolic process (GO:0043171)4.01298299
77renal system process involved in regulation of blood volume (GO:0001977)4.01157640
78alkaloid metabolic process (GO:0009820)3.95012868
79O-glycan processing (GO:0016266)3.94651324
80positive regulation of glycoprotein biosynthetic process (GO:0010560)3.92626762
81regulation of hormone biosynthetic process (GO:0046885)3.91555390
82antimicrobial humoral response (GO:0019730)3.91547273
83cellular response to nitric oxide (GO:0071732)3.89118857
84drug catabolic process (GO:0042737)3.86366614
85protein-lipid complex assembly (GO:0065005)3.83976205
86positive regulation of cytokine production involved in immune response (GO:0002720)3.83733873
87phosphatidic acid biosynthetic process (GO:0006654)3.82249236
88phosphatidic acid metabolic process (GO:0046473)3.82249236
89galactose metabolic process (GO:0006012)3.80575516
90vitamin transport (GO:0051180)3.80453304
91positive regulation of cGMP biosynthetic process (GO:0030828)3.80315452
92phospholipid efflux (GO:0033700)3.70094196
93cGMP biosynthetic process (GO:0006182)3.70057459
94homocysteine metabolic process (GO:0050667)3.69958052
95exogenous drug catabolic process (GO:0042738)3.68752986
96cytidine metabolic process (GO:0046087)3.68304468
97cytidine catabolic process (GO:0006216)3.68304468
98cytidine deamination (GO:0009972)3.68304468
99glutamine family amino acid biosynthetic process (GO:0009084)3.67791970
100defense response to Gram-positive bacterium (GO:0050830)3.61716655
101ceramide catabolic process (GO:0046514)3.59724965
102glycosylceramide metabolic process (GO:0006677)3.59200676
103midgut development (GO:0007494)3.58114285
104digestion (GO:0007586)3.56024085
105tumor necrosis factor-mediated signaling pathway (GO:0033209)3.54469468
106negative regulation of keratinocyte proliferation (GO:0010839)3.53622008
107regulation of hormone metabolic process (GO:0032350)3.52793918
108UDP-N-acetylglucosamine metabolic process (GO:0006047)3.50703235
109positive regulation of glycoprotein metabolic process (GO:1903020)3.49568869
110regulation of cholesterol esterification (GO:0010872)3.47251760
111vitamin biosynthetic process (GO:0009110)3.45946561
112regulation of viral entry into host cell (GO:0046596)3.44464107
113fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.43822599
114regulation of actin nucleation (GO:0051125)3.41221734
115negative regulation of protein tyrosine kinase activity (GO:0061099)3.39841504
116pyrimidine ribonucleoside catabolic process (GO:0046133)3.38297011
117positive regulation of pseudopodium assembly (GO:0031274)3.38283413
118response to nitric oxide (GO:0071731)3.38195331
119vitamin D metabolic process (GO:0042359)3.37803361
120positive regulation of glucose import (GO:0046326)3.36955836
121arginine metabolic process (GO:0006525)3.36353953
122sulfate transmembrane transport (GO:1902358)3.36151460
123positive regulation of lipoprotein lipase activity (GO:0051006)3.35529295
124positive regulation of triglyceride lipase activity (GO:0061365)3.35529295
125sphingomyelin metabolic process (GO:0006684)3.34690450
126citrulline biosynthetic process (GO:0019240)3.34398119
127drug transport (GO:0015893)3.33690747
128glucose 6-phosphate metabolic process (GO:0051156)3.32992401
129heme transport (GO:0015886)3.32704363
130regulation of protein glycosylation (GO:0060049)3.31998876
131positive regulation of cGMP metabolic process (GO:0030825)3.30791369
132adhesion of symbiont to host (GO:0044406)3.27940216
133cellular response to reactive nitrogen species (GO:1902170)3.27854271
134drug transmembrane transport (GO:0006855)3.26940344
135sphingolipid catabolic process (GO:0030149)3.26629224
136glycoside metabolic process (GO:0016137)3.24955178
137cobalamin metabolic process (GO:0009235)3.23579474
138negative regulation of steroid metabolic process (GO:0045939)3.23209242
139killing of cells of other organism (GO:0031640)3.22929207
140disruption of cells of other organism (GO:0044364)3.22929207
141positive regulation of lipid catabolic process (GO:0050996)3.22832867
142lung cell differentiation (GO:0060479)3.22132971
143defense response to fungus (GO:0050832)3.21952053
144nucleoside diphosphate biosynthetic process (GO:0009133)3.20659145
145embryonic process involved in female pregnancy (GO:0060136)3.19813183
146phenol-containing compound catabolic process (GO:0019336)3.19756546
147leukocyte tethering or rolling (GO:0050901)3.18911493
148lung epithelial cell differentiation (GO:0060487)3.18761495
149modified amino acid transport (GO:0072337)3.18229866
150cholesterol homeostasis (GO:0042632)3.17896478
151negative regulation of epidermal cell differentiation (GO:0045605)3.15059493
152cellular response to fatty acid (GO:0071398)3.14959359
153galactose catabolic process (GO:0019388)3.14511015
154phosphatidylglycerol metabolic process (GO:0046471)3.13947005
155diacylglycerol metabolic process (GO:0046339)3.12433434
156regulation of keratinocyte proliferation (GO:0010837)3.04627990
157sulfur amino acid catabolic process (GO:0000098)3.04458527
158regulation of cytokine production involved in immune response (GO:0002718)3.00665304
159response to hepatocyte growth factor (GO:0035728)2.99790071
160cellular response to hepatocyte growth factor stimulus (GO:0035729)2.99790071
161drinking behavior (GO:0042756)2.99505976
162N-acetylglucosamine metabolic process (GO:0006044)2.98630112
163purine deoxyribonucleotide catabolic process (GO:0009155)2.94352561
164negative regulation of sodium ion transport (GO:0010766)2.94346864
165cardiac conduction (GO:0061337)2.91254379
166positive regulation of acute inflammatory response (GO:0002675)2.91043670
167nucleotide transmembrane transport (GO:1901679)2.88867686
168positive regulation of cell fate commitment (GO:0010455)2.88658186
169phosphatidylcholine metabolic process (GO:0046470)2.88026177
170lipoprotein metabolic process (GO:0042157)2.82320266
171positive regulation of glucose transport (GO:0010828)2.79630356
172response to histamine (GO:0034776)2.78515369
173regulation of podosome assembly (GO:0071801)2.78487398
174positive regulation of inflammatory response (GO:0050729)2.76879517
175regulation of viral release from host cell (GO:1902186)2.72875288
176vitamin A metabolic process (GO:0006776)2.71703836
177columnar/cuboidal epithelial cell development (GO:0002066)2.70701932
178sulfur compound transport (GO:0072348)2.68715394
179positive regulation of monocyte chemotaxis (GO:0090026)2.66238880
180desmosome organization (GO:0002934)2.65649920
181actin filament capping (GO:0051693)2.64938199
182antibacterial humoral response (GO:0019731)2.64536639
183negative regulation of actin filament depolymerization (GO:0030835)2.61682615
184low-density lipoprotein particle remodeling (GO:0034374)12.3550095

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1CDX2_20551321_ChIP-Seq_CACO-2_Human4.38360677
2TRIM28_21343339_ChIP-Seq_HEK293_Human4.02402596
3TP63_17297297_ChIP-ChIP_HaCaT_Human3.96115230
4THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse3.63405106
5ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.38925266
6ESR1_20079471_ChIP-ChIP_T-47D_Human3.15733669
7BP1_19119308_ChIP-ChIP_Hs578T_Human3.08868640
8CDX2_19796622_ChIP-Seq_MESCs_Mouse2.93800814
9EGR1_23403033_ChIP-Seq_LIVER_Mouse2.64491465
10SOX2_27498859_Chip-Seq_STOMACH_Mouse2.56796726
11SOX2_20726797_ChIP-Seq_SW620_Human2.51211482
12PPARA_22158963_ChIP-Seq_LIVER_Mouse2.43990533
13GATA6_25053715_ChIP-Seq_YYC3_Human2.32196866
14GATA1_22025678_ChIP-Seq_K562_Human2.30178169
15GATA4_25053715_ChIP-Seq_YYC3_Human2.23754267
16RXR_22158963_ChIP-Seq_LIVER_Mouse2.14541263
17ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse2.01117207
18PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.97403338
19LXR_22158963_ChIP-Seq_LIVER_Mouse1.92725751
20STAT1_20625510_ChIP-Seq_HELA_Human1.92650476
21IRF8_22096565_ChIP-ChIP_GC-B_Human1.83108757
22* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.80946050
23ZNF263_19887448_ChIP-Seq_K562_Human1.79023230
24AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.78439108
25RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.76909430
26SRY_22984422_ChIP-ChIP_TESTIS_Rat1.69225190
27ESR2_21235772_ChIP-Seq_MCF-7_Human1.68631340
28IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.68478757
29TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.63744893
30HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.61171765
31CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.60629692
32FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.59461360
33KLF5_25053715_ChIP-Seq_YYC3_Human1.52742266
34* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.52663911
35FOXO3_23340844_ChIP-Seq_DLD1_Human1.52537651
36LXR_22292898_ChIP-Seq_THP-1_Human1.46522078
37TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.44578685
38* CDX2_22108803_ChIP-Seq_LS180_Human1.43591545
39ERG_21242973_ChIP-ChIP_JURKAT_Human1.41487381
40RUNX1_27514584_Chip-Seq_MCF-7_Human1.40924824
41HNF4A_19822575_ChIP-Seq_HepG2_Human1.39908370
42* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.39626016
43RACK7_27058665_Chip-Seq_MCF-7_Human1.38856376
44IRF8_21731497_ChIP-ChIP_J774_Mouse1.37975836
45KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.37419344
46CLOCK_20551151_ChIP-Seq_293T_Human1.37322769
47DNAJC2_21179169_ChIP-ChIP_NT2_Human1.31854191
48STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.25660942
49GATA2_21666600_ChIP-Seq_HMVEC_Human1.25361018
50SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.25272973
51SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.23188259
52TCF4_18268006_ChIP-ChIP_LS174T_Human1.22811173
53GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.22578441
54FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.21167455
55* GATA2_19941826_ChIP-Seq_K562_Human1.20037721
56NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.18951531
57BCAT_22108803_ChIP-Seq_LS180_Human1.18302405
58BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.17407242
59POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.17309948
60CTCF_27219007_Chip-Seq_Bcells_Human1.15255007
61SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.15172769
62ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.13626118
63KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.13453269
64GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13402237
65DROSHA_22980978_ChIP-Seq_HELA_Human1.12873279
66KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.12360630
67STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.11744339
68NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.10512757
69* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.09320532
70AR_21909140_ChIP-Seq_LNCAP_Human1.08995645
71IKZF1_21737484_ChIP-ChIP_HCT116_Human1.08497632
72TP53_16413492_ChIP-PET_HCT116_Human1.08258429
73RXR_22108803_ChIP-Seq_LS180_Human1.08073642
74ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.07906380
75* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.07708679
76PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.06398691
77MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.03601591
78NANOG_20526341_ChIP-Seq_ESCs_Human1.03513809
79ZNF217_24962896_ChIP-Seq_MCF-7_Human1.03030407
80GATA3_24758297_ChIP-Seq_MCF-7_Human1.02811053
81VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.01129605
82CEBPB_22108803_ChIP-Seq_LS180_Human0.99842184
83SA1_27219007_Chip-Seq_Bcells_Human0.98264837
84KDM2B_26808549_Chip-Seq_SUP-B15_Human0.98246544
85ATF3_27146783_Chip-Seq_COLON_Human0.97973821
86PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.97495401
87EGR1_19032775_ChIP-ChIP_M12_Human0.96882224
88CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96866423
89BCOR_27268052_Chip-Seq_Bcells_Human0.96213073
90SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.95974374
91FOXA1_25552417_ChIP-Seq_VCAP_Human0.95781391
92TP63_23658742_ChIP-Seq_EP156T_Human0.95745499
93FOXA2_19822575_ChIP-Seq_HepG2_Human0.95465612
94MTF2_20144788_ChIP-Seq_MESCs_Mouse0.95329846
95PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.94466688
96TCF3_18692474_ChIP-Seq_MEFs_Mouse0.93968196
97FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.93943136
98BCL6_27268052_Chip-Seq_Bcells_Human0.92200492
99NR3C1_21868756_ChIP-Seq_MCF10A_Human0.91757681
100ELK3_25401928_ChIP-Seq_HUVEC_Human0.91644500
101CTNNB1_20460455_ChIP-Seq_HCT116_Human0.91138830
102EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.90713721
103GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.90547966
104EZH2_27294783_Chip-Seq_ESCs_Mouse0.90194676
105* GATA1_19941826_ChIP-Seq_K562_Human0.89619311
106TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.89602947
107JARID2_20075857_ChIP-Seq_MESCs_Mouse0.89457791
108RAD21_21589869_ChIP-Seq_MESCs_Mouse0.89113204
109JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.89097895
110* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.88527942
111KAP1_22055183_ChIP-Seq_ESCs_Mouse0.88221035
112CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.88069438
113CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.87983568
114FOXA1_21572438_ChIP-Seq_LNCaP_Human0.86935169
115Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.86766367
116P300_27058665_Chip-Seq_ZR-75-30cells_Human0.85987463
117* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.84630560
118PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.84095235
119SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.83828902
120SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.83201332
121VDR_24787735_ChIP-Seq_THP-1_Human0.82612795
122NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.82225347
123SOX2_22085726_ChIP-Seq_NPCs_Mouse0.82220506
124SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.81662085
125GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.81207250
126EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.81063062
127SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80331070
128FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.80162570
129SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.80114956
130CREB1_26743006_Chip-Seq_LNCaP_Human0.79877317
131SMC4_20622854_ChIP-Seq_HELA_Human0.79851640
132ESR1_21235772_ChIP-Seq_MCF-7_Human0.79620726
133TET1_21451524_ChIP-Seq_MESCs_Mouse0.79179902
134SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.79084468
135CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.78769382
136GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.78289250
137GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.77329507
138HNFA_21074721_ChIP-Seq_CACO-2_Human0.77105762
139TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.76807468
140CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.74997038
141NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.74530333

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis7.53986185
2MP0003868_abnormal_feces_composition5.43434129
3MP0001666_abnormal_nutrient_absorption4.49591972
4MP0005085_abnormal_gallbladder_physiolo3.99184064
5MP0003183_abnormal_peptide_metabolism3.64126062
6MP0010234_abnormal_vibrissa_follicle3.43133754
7MP0004264_abnormal_extraembryonic_tissu3.23579767
8MP0005666_abnormal_adipose_tissue3.03443590
9MP0005365_abnormal_bile_salt2.93340248
10MP0001873_stomach_inflammation2.93275143
11MP0002139_abnormal_hepatobiliary_system2.87750112
12MP0010155_abnormal_intestine_physiology2.87514499
13MP0003866_abnormal_defecation2.82810018
14MP0003252_abnormal_bile_duct2.55980333
15MP0008875_abnormal_xenobiotic_pharmacok2.49103718
16MP0005377_hearing/vestibular/ear_phenot2.38904580
17MP0003878_abnormal_ear_physiology2.38904580
18MP0004858_abnormal_nervous_system2.38477441
19MP0003705_abnormal_hypodermis_morpholog2.19970711
20MP0003191_abnormal_cellular_cholesterol2.13885880
21MP0000477_abnormal_intestine_morphology2.13683109
22MP0001663_abnormal_digestive_system2.11999834
23MP0002822_catalepsy2.11449403
24MP0002277_abnormal_respiratory_mucosa2.07967566
25MP0000490_abnormal_crypts_of2.07151320
26MP0000462_abnormal_digestive_system2.03319927
27MP0001664_abnormal_digestion2.02039425
28MP0009780_abnormal_chondrocyte_physiolo2.01751721
29MP0005409_darkened_coat_color1.93914494
30MP0000465_gastrointestinal_hemorrhage1.86134582
31MP0005381_digestive/alimentary_phenotyp1.83630654
32MP0004019_abnormal_vitamin_homeostasis1.76070819
33MP0005375_adipose_tissue_phenotype1.73299782
34MP0005451_abnormal_body_composition1.65649238
35MP0003300_gastrointestinal_ulcer1.59851459
36MP0001764_abnormal_homeostasis1.59512739
37MP0010329_abnormal_lipoprotein_level1.51439362
38MP0005448_abnormal_energy_balance1.51005322
39MP0003718_maternal_effect1.49135243
40MP0004185_abnormal_adipocyte_glucose1.47160684
41MP0005165_increased_susceptibility_to1.46795912
42MP0010352_gastrointestinal_tract_polyps1.43362374
43MP0005636_abnormal_mineral_homeostasis1.42043218
44MP0000537_abnormal_urethra_morphology1.34167924
45MP0009840_abnormal_foam_cell1.30260421
46MP0003879_abnormal_hair_cell1.30209500
47MP0001188_hyperpigmentation1.28702357
48MP0000678_abnormal_parathyroid_gland1.22189092
49MP0002136_abnormal_kidney_physiology1.21702230
50MP0000538_abnormal_urinary_bladder1.20523113
51MP0005084_abnormal_gallbladder_morpholo1.18255850
52MP0005076_abnormal_cell_differentiation1.17875000
53MP0002396_abnormal_hematopoietic_system1.12398394
54MP0002118_abnormal_lipid_homeostasis1.11271918
55MP0005334_abnormal_fat_pad1.08894193
56MP0001849_ear_inflammation1.07381407
57MP0005167_abnormal_blood-brain_barrier1.03266941
58MP0005535_abnormal_body_temperature1.03167907
59MP0002796_impaired_skin_barrier0.97033690
60MP0005584_abnormal_enzyme/coenzyme_acti0.94983119
61MP0010678_abnormal_skin_adnexa0.91046594
62MP0009643_abnormal_urine_homeostasis0.90806815
63MP0001501_abnormal_sleep_pattern0.88780860
64MP0004782_abnormal_surfactant_physiolog0.86564852
65MP0002876_abnormal_thyroid_physiology0.85979897
66MP0003806_abnormal_nucleotide_metabolis0.84587567
67MP0004270_analgesia0.83253643
68MP0005166_decreased_susceptibility_to0.82694514
69MP0004043_abnormal_pH_regulation0.82441908
70MP0002971_abnormal_brown_adipose0.81424601
71MP0000230_abnormal_systemic_arterial0.78475613
72MP0005670_abnormal_white_adipose0.76827438
73MP0004885_abnormal_endolymph0.75138505
74MP0005023_abnormal_wound_healing0.74685605
75MP0005319_abnormal_enzyme/_coenzyme0.74477018
76MP0001756_abnormal_urination0.73567687
77MP0002089_abnormal_postnatal_growth/wei0.72773158
78MP0004947_skin_inflammation0.72227262
79MP0000609_abnormal_liver_physiology0.72184639
80MP0010030_abnormal_orbit_morphology0.71824279
81MP0008469_abnormal_protein_level0.71582053
82MP0005332_abnormal_amino_acid0.70937762
83MP0001845_abnormal_inflammatory_respons0.69949280
84MP0003724_increased_susceptibility_to0.68624119
85MP0006054_spinal_hemorrhage0.68416949
86MP0000470_abnormal_stomach_morphology0.67581507
87MP0001958_emphysema0.65844140
88MP0002098_abnormal_vibrissa_morphology0.64938955
89MP0009785_altered_susceptibility_to0.64640283
90MP0002148_abnormal_hypersensitivity_rea0.63560437
91MP0001485_abnormal_pinna_reflex0.62948122
92MP0002138_abnormal_hepatobiliary_system0.62792098
93MP0000013_abnormal_adipose_tissue0.62765704
94MP0008872_abnormal_physiological_respon0.61803589
95MP0001765_abnormal_ion_homeostasis0.60187052
96MP0006138_congestive_heart_failure0.58626556
97MP0004859_abnormal_synaptic_plasticity0.58107211
98MP0003075_altered_response_to0.57884972
99MP0001881_abnormal_mammary_gland0.56883709
100MP0010307_abnormal_tumor_latency0.56429706
101MP0000249_abnormal_blood_vessel0.56411197
102MP0009697_abnormal_copulation0.56283966
103MP0009115_abnormal_fat_cell0.56255036
104MP0003091_abnormal_cell_migration0.55928865
105MP0004147_increased_porphyrin_level0.54270555
106MP0002166_altered_tumor_susceptibility0.53978613
107MP0009764_decreased_sensitivity_to0.53968059
108MP0001440_abnormal_grooming_behavior0.53571710
109MP0006082_CNS_inflammation0.53233281
110MP0008873_increased_physiological_sensi0.52994742
111MP0005501_abnormal_skin_physiology0.52165695
112MP0005310_abnormal_salivary_gland0.51747718
113MP0003385_abnormal_body_wall0.50129754
114MP0003453_abnormal_keratinocyte_physiol0.49974887
115MP0003953_abnormal_hormone_level0.48872233
116MP0009379_abnormal_foot_pigmentation0.48183500
117MP0003303_peritoneal_inflammation0.47808436
118MP0000604_amyloidosis0.47349357
119MP0005671_abnormal_response_to0.47306457
120MP0001216_abnormal_epidermal_layer0.46873964
121MP0005025_abnormal_response_to0.46473393
122MP0002078_abnormal_glucose_homeostasis0.46426380
123MP0003950_abnormal_plasma_membrane0.46098770
124MP0005376_homeostasis/metabolism_phenot0.44335135
125MP0003436_decreased_susceptibility_to0.43751073
126MP0009642_abnormal_blood_homeostasis0.43693844
127MP0001835_abnormal_antigen_presentation0.43001871
128MP0005164_abnormal_response_to0.42660985
129MP0005174_abnormal_tail_pigmentation0.42488564
130MP0005387_immune_system_phenotype0.42180323
131MP0001790_abnormal_immune_system0.42180323
132MP0001533_abnormal_skeleton_physiology0.42108242
133MP0005395_other_phenotype0.41957681
134MP0008260_abnormal_autophagy0.41942774
135MP0000467_abnormal_esophagus_morphology0.41804713
136MP0000383_abnormal_hair_follicle0.41619545
137MP0009333_abnormal_splenocyte_physiolog0.41547595
138MP0002896_abnormal_bone_mineralization0.41118858
139MP0009053_abnormal_anal_canal0.41000983
140MP0003638_abnormal_response/metabolism_0.35591696

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glutamine family amino acid metabolism (HP:0010902)6.29530792
2Right ventricular cardiomyopathy (HP:0011663)6.19282937
3Micronodular cirrhosis (HP:0001413)5.94701074
4Ileus (HP:0002595)5.06741485
5Abnormality of the vitamin B12 metabolism (HP:0004341)4.74980491
6Hydroxyprolinuria (HP:0003080)4.70083453
7Abnormality of proline metabolism (HP:0010907)4.70083453
8Bundle branch block (HP:0011710)4.48726625
9Abnormality of vitamin B metabolism (HP:0004340)4.47568443
10Pigmentary retinal degeneration (HP:0001146)4.34386410
11Abdominal distention (HP:0003270)4.34359073
12Esophageal varix (HP:0002040)4.12876485
13Abnormality of sulfur amino acid metabolism (HP:0004339)4.04267255
14Abnormality of vitamin metabolism (HP:0100508)3.98385921
15Chronic diarrhea (HP:0002028)3.87821565
16Syncope (HP:0001279)3.83588282
17Fat malabsorption (HP:0002630)3.77923810
18Nausea (HP:0002018)3.74323927
19Malnutrition (HP:0004395)3.60815527
20Hyperparathyroidism (HP:0000843)3.57990044
21Confusion (HP:0001289)3.45778049
22Hyperactive renin-angiotensin system (HP:0000841)3.45310862
23Wide cranial sutures (HP:0010537)3.44092212
24Proximal tubulopathy (HP:0000114)3.43935027
25Abnormality of aspartate family amino acid metabolism (HP:0010899)3.43161344
26Woolly hair (HP:0002224)3.40919719
27Intrahepatic cholestasis (HP:0001406)3.39732616
28Abnormality of monocarboxylic acid metabolism (HP:0010996)3.29564546
29Decreased circulating renin level (HP:0003351)3.25399679
30Systemic lupus erythematosus (HP:0002725)3.17159807
31Alkalosis (HP:0001948)3.04166846
32Posterior subcapsular cataract (HP:0007787)3.01484527
33Prolonged QT interval (HP:0001657)2.98330517
34Increased purine levels (HP:0004368)2.94189897
35Hyperuricemia (HP:0002149)2.94189897
36Hypophosphatemia (HP:0002148)2.90975240
37Xanthomatosis (HP:0000991)2.86463306
38Oligomenorrhea (HP:0000876)2.85407005
39Abnormal urine phosphate concentration (HP:0012599)2.84666804
40Enlarged epiphyses (HP:0010580)2.84567315
41Metabolic alkalosis (HP:0200114)2.76702971
42Hyperammonemia (HP:0001987)2.76614318
43Potter facies (HP:0002009)2.75127691
44Facial shape deformation (HP:0011334)2.75127691
45Hyperglycinuria (HP:0003108)2.75099912
46Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.73109535
47Abnormal foot bone ossification (HP:0010675)2.70778600
48Conjugated hyperbilirubinemia (HP:0002908)2.64747391
49Delayed epiphyseal ossification (HP:0002663)2.63692721
50Steatorrhea (HP:0002570)2.63424539
51Eczematoid dermatitis (HP:0000976)2.62310187
52Palpitations (HP:0001962)2.58583487
53Poikilocytosis (HP:0004447)2.54421009
54Abnormality of renin-angiotensin system (HP:0000847)2.54242094
55Exocrine pancreatic insufficiency (HP:0001738)2.53948880
56Amyloidosis (HP:0011034)2.51790766
57Goiter (HP:0000853)2.49790114
58Hypoalphalipoproteinemia (HP:0003233)2.48429205
59Abnormality of the costochondral junction (HP:0000919)2.46980615
60Hypolipoproteinemia (HP:0010981)2.46874855
61Ventricular tachycardia (HP:0004756)2.45167641
62Hypercholesterolemia (HP:0003124)2.45128457
63Hypoplastic ischia (HP:0003175)2.42065990
64Metabolic acidosis (HP:0001942)2.41556963
65Hypercortisolism (HP:0001578)2.38906304
66Glycosuria (HP:0003076)2.37774038
67Abnormality of urine glucose concentration (HP:0011016)2.37774038
68Abnormality of purine metabolism (HP:0004352)2.37440968
69Abnormal glucose tolerance (HP:0001952)2.35112657
70Hypobetalipoproteinemia (HP:0003563)2.34336277
71Focal segmental glomerulosclerosis (HP:0000097)2.33396049
72Epidermoid cyst (HP:0200040)2.33272373
73Hypotension (HP:0002615)2.32623938
74Heart block (HP:0012722)2.32351748
75Generalized aminoaciduria (HP:0002909)2.30690149
76Abnormal atrioventricular conduction (HP:0005150)2.30631810
77Abnormality of the gastric mucosa (HP:0004295)2.30290402
78Hyperlipoproteinemia (HP:0010980)2.30052311
79Myopathic facies (HP:0002058)2.29425964
80Megaloblastic anemia (HP:0001889)2.28176341
81Multiple lipomas (HP:0001012)2.18997592
82Subcapsular cataract (HP:0000523)2.15729923
83Cerebral palsy (HP:0100021)2.12670106
84Protuberant abdomen (HP:0001538)2.09458398
85Abnormality of the ischium (HP:0003174)2.06892393
86Nephrolithiasis (HP:0000787)2.06095566
87Acanthocytosis (HP:0001927)2.04588109
88Mildly elevated creatine phosphokinase (HP:0008180)2.02741280
89Late onset (HP:0003584)2.01975606
90Renal tubular acidosis (HP:0001947)2.01575992
91Abnormal vertebral ossification (HP:0100569)2.01380777
92Renal tubular dysfunction (HP:0000124)1.99947367
93Dysmetric saccades (HP:0000641)1.99821406
94Irritability (HP:0000737)1.99535923
95Atrophic scars (HP:0001075)1.98662472
96Gout (HP:0001997)1.98298762
97Gastrointestinal dysmotility (HP:0002579)1.97373053
98Gingivitis (HP:0000230)1.95712743
99Hyperphosphatemia (HP:0002905)1.95579006
100Abnormality of magnesium homeostasis (HP:0004921)1.94530779
101Progressive hearing impairment (HP:0001730)1.92193531
102Congenital, generalized hypertrichosis (HP:0004540)1.91613773
103Dehydration (HP:0001944)1.89098971
104Hemorrhage of the eye (HP:0011885)1.86609530
105Dicarboxylic aciduria (HP:0003215)1.85042808
106Abnormality of dicarboxylic acid metabolism (HP:0010995)1.85042808
107Villous atrophy (HP:0011473)1.83044291
108Abnormality of small intestinal villus morphology (HP:0011472)1.83044291
109Growth hormone excess (HP:0000845)1.82771841
110Widely patent fontanelles and sutures (HP:0004492)1.82188721
111Pancreatitis (HP:0001733)1.81506773
112Abnormality of serine family amino acid metabolism (HP:0010894)1.79415527
113Abnormality of glycine metabolism (HP:0010895)1.79415527
114Congenital sensorineural hearing impairment (HP:0008527)1.77955402
115Bradycardia (HP:0001662)1.77421750
116Metaphyseal irregularity (HP:0003025)1.75973980
117Action tremor (HP:0002345)1.74724082
118Stridor (HP:0010307)1.73775100
119Hemiplegia (HP:0002301)1.73716490
120Abnormality of abdominal situs (HP:0011620)1.73411545
121Abdominal situs inversus (HP:0003363)1.73411545
122Abnormal enzyme/coenzyme activity (HP:0012379)1.73295174
123Thin bony cortex (HP:0002753)1.72645259
124Abnormality of alkaline phosphatase activity (HP:0004379)1.72524069
125Aplasia/Hypoplasia of the clavicles (HP:0006710)1.71961340
126Glomerulosclerosis (HP:0000096)1.71495983
127Abnormal pancreas size (HP:0012094)1.70374126
128Hypophosphatemic rickets (HP:0004912)1.69393315
129Sensorimotor neuropathy (HP:0007141)1.68351531
130Flat acetabular roof (HP:0003180)1.68172135
131Hypoglycemic coma (HP:0001325)1.67694864
132Biliary tract neoplasm (HP:0100574)1.67405001
133Abnormality of nucleobase metabolism (HP:0010932)1.66913138
134Ventricular arrhythmia (HP:0004308)1.66907335
135Hyperphosphaturia (HP:0003109)1.66680160
136Symptomatic seizures (HP:0011145)1.66416249
137Peripheral demyelination (HP:0011096)1.66314437
138Abnormal biliary tract morphology (HP:0012440)1.65781545
139Patchy hypopigmentation of hair (HP:0011365)1.65553684
140Lethargy (HP:0001254)1.65345978
141Interstitial pulmonary disease (HP:0006530)1.64597294
142White forelock (HP:0002211)1.64435292
143Hoarse voice (HP:0001609)1.64080186
144Orchitis (HP:0100796)1.63610295
145Childhood onset (HP:0011463)1.63454758
146Deep venous thrombosis (HP:0002625)1.63237116
147Milia (HP:0001056)1.62979367
148Rectal prolapse (HP:0002035)1.61573661
149Abnormal hand bone ossification (HP:0010660)1.61568400
150Polygenic inheritance (HP:0010982)1.61334605
151Agitation (HP:0000713)1.61121588
152Pustule (HP:0200039)1.60723598
153Abnormal EKG (HP:0003115)1.60403644
154Abnormality of pyrimidine metabolism (HP:0004353)1.60392766
155Hypoalbuminemia (HP:0003073)1.59903731

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B9.50953617
2FRK6.73718142
3NME16.21646317
4RPS6KB23.98059991
5MST43.91415610
6PIK3CA2.91195498
7STK242.76640385
8STK392.74651873
9MAP2K22.66392238
10ERN12.54366436
11MST1R2.47544998
12TEC2.46718432
13PTK62.32916559
14TAOK12.21381628
15OXSR12.19327579
16GRK62.08893193
17EEF2K1.91995508
18EPHB21.88250977
19BLK1.74585424
20MAP3K21.72601089
21TESK21.72268654
22LMTK21.64097823
23TNIK1.58689611
24KSR21.58071093
25EPHA31.54620191
26CAMK2D1.49665981
27TAOK31.46234049
28LATS11.41975553
29MAP2K11.41780279
30AKT31.39465296
31FGFR41.39406996
32TYK21.39337743
33TESK11.35241606
34MAP3K71.34683866
35MAP3K111.32821337
36PRKG21.27757431
37CAMK2B1.24595048
38RIPK11.15283609
39PIM11.10929644
40MYLK1.10313000
41EPHA41.08956426
42EPHA21.05591425
43TRIB31.04051810
44NLK0.96623521
45MAP3K120.96198285
46MAP3K60.95358400
47MAP3K100.95317687
48BMPR20.93952594
49CAMK2G0.92919591
50FGFR30.89944531
51FER0.89461708
52CSK0.88175724
53MAP3K10.85384813
54PAK40.85127164
55CASK0.84027697
56PTK20.81900354
57PRPF4B0.78231966
58STK100.78076779
59TBK10.75720676
60LRRK20.75174869
61MAP3K80.74992529
62PRKACG0.74175798
63ILK0.71337636
64NUAK10.68377070
65RIPK40.63837444
66ITK0.62496254
67MET0.61323449
68PRKCZ0.60691670
69IRAK10.58260594
70CAMK10.56251353
71MAPK110.55699694
72PAK30.55363212
73LIMK10.55088235
74PIK3CG0.54482395
75ERBB20.50435999
76MAP3K30.47984333
77DDR20.47545910
78PRKCI0.46600386
79YES10.44898825
80MAPKAPK20.44416777
81PRKCQ0.43493290
82PKN20.43447028
83TRPM70.42950618
84JAK10.41873258
85MAPKAPK30.41291734
86PRKCE0.40715914
87SRC0.38916567
88ABL20.38074697
89NEK60.37937387
90GRK10.37483978
91CDK60.37078331
92RET0.36470455
93JAK20.35744955
94PIM20.35630711
95PRKAA20.35088198
96FYN0.34430360
97PRKCA0.34040240
98CSNK1G30.33399814
99CSNK1A10.33184078
100SYK0.31093908
101EPHB10.30147311
102PDPK10.29497453
103CDK120.29049620
104BMX0.28902067
105CDK190.27483246
106DYRK1B0.27277573
107MAPK150.27154468
108PAK10.26772405
109LYN0.26465147
110CSF1R0.25798840
111CAMK2A0.25577056
112IKBKE0.25229141
113CSNK1A1L0.24971348
114PDK10.24550520
115ROCK20.23528180
116PRKACA0.23280385
117MATK0.23142065
118MAP3K140.23065138
119MELK0.22757956
120CSNK1G20.22230765
121TAOK20.22194176
122MAP4K10.21442109
123MAP2K60.20718208
124PDK20.20282100
125ERBB30.19600249
126ERBB40.18066420
127DAPK20.15907329
128CAMKK10.15362189
129PRKCB0.15248103
130DAPK30.14857943
131PRKCD0.13951899
132BTK0.13040586
133MAP2K30.12724284
134CDC42BPA0.12633878
135BCR0.12379264
136MAPKAPK50.12093937
137DMPK0.11458841

Predicted pathways (KEGG)

RankGene SetZ-score
1Fat digestion and absorption_Homo sapiens_hsa049755.99837945
2alpha-Linolenic acid metabolism_Homo sapiens_hsa005924.52854730
3Linoleic acid metabolism_Homo sapiens_hsa005914.46863756
4Sulfur metabolism_Homo sapiens_hsa009203.60884408
5Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005333.60295938
6Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.51434205
7Renin-angiotensin system_Homo sapiens_hsa046143.00941717
8Bile secretion_Homo sapiens_hsa049762.91310207
9Ether lipid metabolism_Homo sapiens_hsa005652.59713684
10Drug metabolism - other enzymes_Homo sapiens_hsa009832.21178792
11Arachidonic acid metabolism_Homo sapiens_hsa005902.19806332
12Mineral absorption_Homo sapiens_hsa049782.15156120
13Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.12302831
14Retinol metabolism_Homo sapiens_hsa008302.06293935
15Protein digestion and absorption_Homo sapiens_hsa049741.67917389
16Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.61021015
17Galactose metabolism_Homo sapiens_hsa000521.54327675
18Pancreatic secretion_Homo sapiens_hsa049721.51366439
19Histidine metabolism_Homo sapiens_hsa003401.46965594
20Maturity onset diabetes of the young_Homo sapiens_hsa049501.36085877
21Vitamin digestion and absorption_Homo sapiens_hsa049771.31880437
22Glycerophospholipid metabolism_Homo sapiens_hsa005641.31368436
23Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.30802056
24Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.16974976
25Fructose and mannose metabolism_Homo sapiens_hsa000511.15250603
26* PPAR signaling pathway_Homo sapiens_hsa033201.13543992
27Phenylalanine metabolism_Homo sapiens_hsa003601.10050377
28Cyanoamino acid metabolism_Homo sapiens_hsa004601.04056322
29Vibrio cholerae infection_Homo sapiens_hsa051101.02190757
30Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.00816866
31Starch and sucrose metabolism_Homo sapiens_hsa005000.98783884
32Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.98487276
33Glutathione metabolism_Homo sapiens_hsa004800.96750826
34Leukocyte transendothelial migration_Homo sapiens_hsa046700.94538765
35Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.94309649
36Glycerolipid metabolism_Homo sapiens_hsa005610.94011152
37Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.93299307
38Vascular smooth muscle contraction_Homo sapiens_hsa042700.93138468
39Tight junction_Homo sapiens_hsa045300.93125950
40Carbohydrate digestion and absorption_Homo sapiens_hsa049730.81204873
41Sphingolipid metabolism_Homo sapiens_hsa006000.80673584
42Tryptophan metabolism_Homo sapiens_hsa003800.79469912
43Asthma_Homo sapiens_hsa053100.79244397
44Thyroid hormone synthesis_Homo sapiens_hsa049180.76497220
45Intestinal immune network for IgA production_Homo sapiens_hsa046720.76377891
46Hepatitis C_Homo sapiens_hsa051600.74368702
47Caffeine metabolism_Homo sapiens_hsa002320.74273306
48Pentose phosphate pathway_Homo sapiens_hsa000300.73652857
49Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.72656905
50Thyroid cancer_Homo sapiens_hsa052160.64642063
51Pyruvate metabolism_Homo sapiens_hsa006200.62409615
52Fatty acid degradation_Homo sapiens_hsa000710.60833626
53Arginine biosynthesis_Homo sapiens_hsa002200.59428979
54Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.56922390
55Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.56383622
56ABC transporters_Homo sapiens_hsa020100.55621181
57Folate biosynthesis_Homo sapiens_hsa007900.55249007
58Nitrogen metabolism_Homo sapiens_hsa009100.53798538
59Gastric acid secretion_Homo sapiens_hsa049710.52477604
60Allograft rejection_Homo sapiens_hsa053300.52004229
61Pentose and glucuronate interconversions_Homo sapiens_hsa000400.51789716
62Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.50083813
63Peroxisome_Homo sapiens_hsa041460.49800933
64Selenocompound metabolism_Homo sapiens_hsa004500.49347907
65Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.47937431
66Autoimmune thyroid disease_Homo sapiens_hsa053200.47685049
67Tyrosine metabolism_Homo sapiens_hsa003500.47173506
68Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.47125814
69Fatty acid biosynthesis_Homo sapiens_hsa000610.47057841
70Fatty acid metabolism_Homo sapiens_hsa012120.45894342
71Graft-versus-host disease_Homo sapiens_hsa053320.45002549
72Amoebiasis_Homo sapiens_hsa051460.43294655
73Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.42798184
74Salmonella infection_Homo sapiens_hsa051320.42689863
75Alzheimers disease_Homo sapiens_hsa050100.42679139
76Renin secretion_Homo sapiens_hsa049240.40120923
77Insulin secretion_Homo sapiens_hsa049110.39424113
78Arginine and proline metabolism_Homo sapiens_hsa003300.38427736
79Steroid hormone biosynthesis_Homo sapiens_hsa001400.37102448
80Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.36943353
81GnRH signaling pathway_Homo sapiens_hsa049120.35238171
82Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.35088497
83Butanoate metabolism_Homo sapiens_hsa006500.34893377
84Carbon metabolism_Homo sapiens_hsa012000.34455794
85Type II diabetes mellitus_Homo sapiens_hsa049300.33883895
86Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.33403951
87Oxidative phosphorylation_Homo sapiens_hsa001900.33106535
88Type I diabetes mellitus_Homo sapiens_hsa049400.30479196
89Parkinsons disease_Homo sapiens_hsa050120.29938184
90Cardiac muscle contraction_Homo sapiens_hsa042600.29906815
91Salivary secretion_Homo sapiens_hsa049700.29873399
92African trypanosomiasis_Homo sapiens_hsa051430.29842229
93Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.29452668
94Ras signaling pathway_Homo sapiens_hsa040140.29138868
95Staphylococcus aureus infection_Homo sapiens_hsa051500.27989384
96Gap junction_Homo sapiens_hsa045400.27112683
97Bladder cancer_Homo sapiens_hsa052190.25361743
98Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.25359667
99Insulin resistance_Homo sapiens_hsa049310.24211360
100beta-Alanine metabolism_Homo sapiens_hsa004100.23951519
101Adipocytokine signaling pathway_Homo sapiens_hsa049200.23937626
102Primary bile acid biosynthesis_Homo sapiens_hsa001200.23754709
103Metabolic pathways_Homo sapiens_hsa011000.23653764
1042-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.22664101
105Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.22540983
106Cocaine addiction_Homo sapiens_hsa050300.22503233
107Chemical carcinogenesis_Homo sapiens_hsa052040.21267154
108Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.21174907
109Biosynthesis of amino acids_Homo sapiens_hsa012300.20944839
110Long-term depression_Homo sapiens_hsa047300.20943459
111VEGF signaling pathway_Homo sapiens_hsa043700.20571972
112Pertussis_Homo sapiens_hsa051330.20403402
113Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.20012667
114Adherens junction_Homo sapiens_hsa045200.19123126
115Dorso-ventral axis formation_Homo sapiens_hsa043200.17661157
116Aldosterone synthesis and secretion_Homo sapiens_hsa049250.17611077
117Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.16940683
118Serotonergic synapse_Homo sapiens_hsa047260.16512916
119Sulfur relay system_Homo sapiens_hsa041220.15250493
120Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.15003363
121Antigen processing and presentation_Homo sapiens_hsa046120.13504435
122Central carbon metabolism in cancer_Homo sapiens_hsa052300.11474064
123Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.10970634
124HIF-1 signaling pathway_Homo sapiens_hsa040660.09848360
125Amphetamine addiction_Homo sapiens_hsa050310.09314445
126Glucagon signaling pathway_Homo sapiens_hsa049220.09126828
127Cholinergic synapse_Homo sapiens_hsa047250.09064525
128Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.08668376
129Steroid biosynthesis_Homo sapiens_hsa001000.08634816
130TGF-beta signaling pathway_Homo sapiens_hsa043500.08437829
131Other glycan degradation_Homo sapiens_hsa005110.08300057
132Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.08072232
133Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.07316724
134Leishmaniasis_Homo sapiens_hsa051400.06981707
135Hematopoietic cell lineage_Homo sapiens_hsa046400.04045019
136Viral myocarditis_Homo sapiens_hsa05416-0.0521252
137Fatty acid elongation_Homo sapiens_hsa00062-0.0250731
138Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962-0.0223994
139Propanoate metabolism_Homo sapiens_hsa00640-0.0199099
140Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0066167

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