FADD

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.50455734
2protein maturation by protein folding (GO:0022417)4.75851802
3Golgi transport vesicle coating (GO:0048200)4.61228136
4COPI coating of Golgi vesicle (GO:0048205)4.61228136
5ribosomal small subunit assembly (GO:0000028)4.47051085
6negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.35470767
7protein localization to endosome (GO:0036010)4.05650949
8antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.99773962
9pentose-phosphate shunt (GO:0006098)3.96211347
10telomere maintenance via semi-conservative replication (GO:0032201)3.84656186
11deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.69753375
12protein retention in ER lumen (GO:0006621)3.62171686
13DNA unwinding involved in DNA replication (GO:0006268)3.55666677
14NADPH regeneration (GO:0006740)3.51105522
15pinocytosis (GO:0006907)3.48989399
16response to interferon-beta (GO:0035456)3.48186906
17telomere maintenance via recombination (GO:0000722)3.47028515
18maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.44039535
19respiratory chain complex IV assembly (GO:0008535)3.42837730
20glucose catabolic process (GO:0006007)3.41732449
21regulation of mammary gland epithelial cell proliferation (GO:0033599)3.40265119
22establishment of integrated proviral latency (GO:0075713)3.34833542
23establishment of viral latency (GO:0019043)3.33952060
24barbed-end actin filament capping (GO:0051016)3.33602842
25DNA strand elongation involved in DNA replication (GO:0006271)3.33573260
26DNA strand elongation (GO:0022616)3.29970517
27nucleobase-containing small molecule interconversion (GO:0015949)3.28837687
28positive regulation of Cdc42 GTPase activity (GO:0043089)3.24704776
29mitotic chromosome condensation (GO:0007076)3.18623784
30proline biosynthetic process (GO:0006561)3.15408590
31definitive hemopoiesis (GO:0060216)3.14805651
32cytochrome complex assembly (GO:0017004)3.13230801
33tRNA methylation (GO:0030488)3.12411591
34polyketide metabolic process (GO:0030638)3.09157131
35doxorubicin metabolic process (GO:0044598)3.09157131
36daunorubicin metabolic process (GO:0044597)3.09157131
37peptidyl-arginine omega-N-methylation (GO:0035247)3.08162341
38nuclear envelope reassembly (GO:0031468)3.06329636
39mitotic nuclear envelope reassembly (GO:0007084)3.06329636
40pyrimidine nucleoside salvage (GO:0043097)3.05190660
41pyrimidine-containing compound salvage (GO:0008655)3.05190660
42mitotic recombination (GO:0006312)3.04503308
43heterochromatin organization (GO:0070828)2.97479956
44regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.94171633
45negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.92090101
46retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.89354271
47platelet dense granule organization (GO:0060155)2.88101325
48regulation of translational termination (GO:0006449)2.87709900
49cellular response to interferon-beta (GO:0035458)2.87122668
50apoptotic process involved in morphogenesis (GO:0060561)2.83328011
51positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.83074288
52telomere maintenance via telomere lengthening (GO:0010833)2.82898239
53positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.82329618
54DNA replication initiation (GO:0006270)2.79660426
55signal peptide processing (GO:0006465)2.74673536
56UV protection (GO:0009650)2.73348416
57immunoglobulin mediated immune response (GO:0016064)2.72793776
58pseudouridine synthesis (GO:0001522)2.72698144
59cellular response to exogenous dsRNA (GO:0071360)2.72660116
60endosome to pigment granule transport (GO:0043485)2.72469151
61endosome to melanosome transport (GO:0035646)2.72469151
62protein complex localization (GO:0031503)2.71335118
63positive regulation of B cell differentiation (GO:0045579)2.70924684
64iron-sulfur cluster assembly (GO:0016226)2.69670503
65metallo-sulfur cluster assembly (GO:0031163)2.69670503
66NIK/NF-kappaB signaling (GO:0038061)2.69504876
67CENP-A containing nucleosome assembly (GO:0034080)2.69481683
68pentose metabolic process (GO:0019321)2.65388953
69DNA replication checkpoint (GO:0000076)2.65180825
70response to interferon-alpha (GO:0035455)2.64588454
71proteasome assembly (GO:0043248)2.63295042
72regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 2.61473330
73histone arginine methylation (GO:0034969)2.58928278
74cellular response to virus (GO:0098586)2.56096360
75ribosomal small subunit biogenesis (GO:0042274)2.55602053
76antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.55267855
77antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.55267855
78regulation of nuclear cell cycle DNA replication (GO:0033262)2.54668182
79maternal placenta development (GO:0001893)2.54002145
80chromatin remodeling at centromere (GO:0031055)2.52936915
81regulation of superoxide anion generation (GO:0032928)2.51436119
82virion assembly (GO:0019068)2.51319025
83mitochondrial fusion (GO:0008053)2.51136514
84nucleotide-excision repair, DNA gap filling (GO:0006297)2.49994308
85deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.48275076
86termination of RNA polymerase III transcription (GO:0006386)2.47444601
87transcription elongation from RNA polymerase III promoter (GO:0006385)2.47444601
88mature B cell differentiation involved in immune response (GO:0002313)2.46703451
89kinetochore assembly (GO:0051382)2.46642710
903-UTR-mediated mRNA stabilization (GO:0070935)2.46623449
91modulation by symbiont of host cellular process (GO:0044068)2.46216895
92pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.45609062
93regulation of RIG-I signaling pathway (GO:0039535)2.44639763
94cellular protein complex localization (GO:0034629)2.44403312
95negative regulation of phagocytosis (GO:0050765)2.44367596
96SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.44176906
97antigen processing and presentation via MHC class Ib (GO:0002475)2.43782169
98lymphoid progenitor cell differentiation (GO:0002320)2.43662993
99exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.42477096
100ribosome assembly (GO:0042255)2.41732761
101mitotic metaphase plate congression (GO:0007080)2.41593866
102cellular response to type I interferon (GO:0071357)2.41336439
103type I interferon signaling pathway (GO:0060337)2.41336439
104endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.41169823
105defense response to protozoan (GO:0042832)2.39379389
106rRNA modification (GO:0000154)2.39248960
107response to type I interferon (GO:0034340)2.38665187
108regulation of B cell differentiation (GO:0045577)2.38610442
109kinetochore organization (GO:0051383)2.38304292
110B cell mediated immunity (GO:0019724)2.38051704
111mannosylation (GO:0097502)2.37735989
112viral transcription (GO:0019083)2.36467019
113telomere maintenance (GO:0000723)2.35772802
114tRNA modification (GO:0006400)2.35466678
115spliceosomal tri-snRNP complex assembly (GO:0000244)2.34666104
116GDP-mannose metabolic process (GO:0019673)2.34094308
117peptidyl-histidine modification (GO:0018202)2.33608275
118telomere organization (GO:0032200)2.33464122
119cell-substrate adherens junction assembly (GO:0007045)2.33145603
120focal adhesion assembly (GO:0048041)2.33145603
121response to peptidoglycan (GO:0032494)2.32550521
122DNA catabolic process, exonucleolytic (GO:0000738)2.31644116
123Arp2/3 complex-mediated actin nucleation (GO:0034314)2.31565457
124cotranslational protein targeting to membrane (GO:0006613)2.31557064
125negative regulation of cell size (GO:0045792)2.30996200
126ribosomal large subunit biogenesis (GO:0042273)2.30912380
127nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.30383923
128nucleotide-sugar biosynthetic process (GO:0009226)2.30252379
129skin morphogenesis (GO:0043589)2.30246590
130protein targeting to ER (GO:0045047)2.30197439
131regulation of early endosome to late endosome transport (GO:2000641)2.29689271
132membrane raft organization (GO:0031579)2.29529802
133positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.29351314
134negative regulation of viral genome replication (GO:0045071)2.29194106
135protein localization to chromosome, centromeric region (GO:0071459)2.29046493
136antigen processing and presentation of endogenous antigen (GO:0019883)2.28647953
137response to protozoan (GO:0001562)2.28211674
138rRNA transcription (GO:0009303)2.27960795
139positive regulation of gamma-delta T cell activation (GO:0046645)2.26747085
140regulation of mitochondrial membrane potential (GO:0051881)2.25749647
141regulation of apoptotic process involved in morphogenesis (GO:1902337)2.25504160
142regulation of translational fidelity (GO:0006450)2.23900954
143neutrophil activation involved in immune response (GO:0002283)2.23710326
1442-deoxyribonucleotide biosynthetic process (GO:0009265)2.23522954
145deoxyribose phosphate biosynthetic process (GO:0046385)2.23522954
146myeloid dendritic cell activation (GO:0001773)2.23253059
147modulation by virus of host process (GO:0019054)2.23155550
148rRNA methylation (GO:0031167)2.23030577
149translational termination (GO:0006415)2.22284188
150peptidyl-arginine methylation (GO:0018216)2.22099448
151peptidyl-arginine N-methylation (GO:0035246)2.22099448
152adherens junction assembly (GO:0034333)2.21928551
153intra-S DNA damage checkpoint (GO:0031573)2.21922969
154hyaluronan catabolic process (GO:0030214)2.21668968
155protein localization to endoplasmic reticulum (GO:0070972)2.21517559
156cell-substrate junction assembly (GO:0007044)2.21489121
157DNA ligation (GO:0006266)2.21365410
158regulation of double-strand break repair via homologous recombination (GO:0010569)2.21241028
159superoxide anion generation (GO:0042554)2.20807934
160centriole assembly (GO:0098534)2.20483396
161antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.20006408
162production of molecular mediator involved in inflammatory response (GO:0002532)2.19893952
163nucleoside salvage (GO:0043174)2.19865583
164maturation of SSU-rRNA (GO:0030490)2.19570392
165negative regulation of myeloid cell apoptotic process (GO:0033033)2.19516820
166RNA methylation (GO:0001510)2.19265035
167formation of translation preinitiation complex (GO:0001731)2.18588379
168negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.18307133
169regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.17808262
170deoxyribonucleotide biosynthetic process (GO:0009263)2.17400003
171cellular response to zinc ion (GO:0071294)2.17301212
172antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.17018855
173regulation of hexokinase activity (GO:1903299)2.16146546
174folic acid metabolic process (GO:0046655)2.15642676
175positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.15470785
176negative regulation of ligase activity (GO:0051352)2.15182177
177negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.15182177
178hemidesmosome assembly (GO:0031581)2.15072410
179positive regulation of keratinocyte differentiation (GO:0045618)2.14785873
180regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 2.14293656
181positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling2.14293656
182activation of Rac GTPase activity (GO:0032863)2.14120147
183stress fiber assembly (GO:0043149)2.12837373
184negative regulation of stress fiber assembly (GO:0051497)2.12505406
185regulation of defense response to virus by virus (GO:0050690)2.10346809
186mitotic sister chromatid segregation (GO:0000070)2.10053077
187muscle cell migration (GO:0014812)2.09239475
188epithelial cell differentiation involved in prostate gland development (GO:0060742)2.09010907
189negative regulation of viral release from host cell (GO:1902187)2.06978204
190mannose metabolic process (GO:0006013)2.06352762

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.55003455
2IRF8_22096565_ChIP-ChIP_GC-B_Human3.55380337
3ELF1_17652178_ChIP-ChIP_JURKAT_Human3.39169599
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.04919026
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.92654927
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.91527775
7SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.85528969
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.83991695
9MYC_18555785_ChIP-Seq_MESCs_Mouse2.76826344
10FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.61824351
11TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.61416493
12TP63_17297297_ChIP-ChIP_HaCaT_Human2.61295865
13GABP_17652178_ChIP-ChIP_JURKAT_Human2.60377301
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.51259551
15NOTCH1_21737748_ChIP-Seq_TLL_Human2.50822264
16EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.50726821
17SCL_19346495_ChIP-Seq_HPC-7_Human2.42472929
18SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.40259119
19IRF8_21731497_ChIP-ChIP_J774_Mouse2.38504894
20SRF_21415370_ChIP-Seq_HL-1_Mouse2.28930793
21MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.25145375
22E2F4_17652178_ChIP-ChIP_JURKAT_Human2.22797303
23ELK3_25401928_ChIP-Seq_HUVEC_Human2.19389242
24IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.18814857
25MYC_18358816_ChIP-ChIP_MESCs_Mouse2.18272045
26* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.17382695
27RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.15079499
28VDR_23849224_ChIP-Seq_CD4+_Human2.14774046
29* TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.12736163
30HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.12563291
31RARG_19884340_ChIP-ChIP_MEFs_Mouse2.11603938
32ETS1_20019798_ChIP-Seq_JURKAT_Human2.11174527
33SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.09845412
34HOXB4_20404135_ChIP-ChIP_EML_Mouse2.07488834
35CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.07062843
36FOXP3_21729870_ChIP-Seq_TREG_Human2.03131663
37HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.02804717
38ERG_20887958_ChIP-Seq_HPC-7_Mouse2.02447418
39* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.01461881
40FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.96616738
41ZNF263_19887448_ChIP-Seq_K562_Human1.95055125
42TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.94999914
43SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.94577878
44SPI1_23547873_ChIP-Seq_NB4_Human1.91457447
45STAT4_19710469_ChIP-ChIP_TH1__Mouse1.90575780
46MYC_19030024_ChIP-ChIP_MESCs_Mouse1.88689373
47BP1_19119308_ChIP-ChIP_Hs578T_Human1.88635148
48NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.81795945
49LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.79838110
50* LXR_22292898_ChIP-Seq_THP-1_Human1.79653442
51PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.75666179
52* RACK7_27058665_Chip-Seq_MCF-7_Human1.72026073
53ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.69785241
54* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.66064205
55CREB1_15753290_ChIP-ChIP_HEK293T_Human1.64415975
56CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.63795022
57* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.61105158
58MYB_21317192_ChIP-Seq_ERMYB_Mouse1.60497383
59ELK1_19687146_ChIP-ChIP_HELA_Human1.60281517
60STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.58542927
61DCP1A_22483619_ChIP-Seq_HELA_Human1.57346319
62TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.52172411
63* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.51254695
64FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.51005684
65* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.50457177
66LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.50286123
67CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.50085356
68ZFX_18555785_ChIP-Seq_MESCs_Mouse1.49669561
69KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.49323888
70CIITA_25753668_ChIP-Seq_RAJI_Human1.48358459
71GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.48080708
72* GABP_19822575_ChIP-Seq_HepG2_Human1.46959461
73KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.46690468
74NELFA_20434984_ChIP-Seq_ESCs_Mouse1.45243205
75KLF4_18555785_ChIP-Seq_MESCs_Mouse1.42902839
76YY1_21170310_ChIP-Seq_MESCs_Mouse1.41701790
77XRN2_22483619_ChIP-Seq_HELA_Human1.40792812
78ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.40754743
79MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.38970263
80* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.38452978
81SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.35349480
82* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.35161344
83MYC_19079543_ChIP-ChIP_MESCs_Mouse1.34776860
84IRF8_27001747_Chip-Seq_BMDM_Mouse1.34421615
85ATF3_27146783_Chip-Seq_COLON_Human1.33183861
86GATA1_22025678_ChIP-Seq_K562_Human1.32838557
87TET1_21451524_ChIP-Seq_MESCs_Mouse1.32741554
88MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.31681615
89MYB_26560356_Chip-Seq_TH2_Human1.31308769
90SRY_22984422_ChIP-ChIP_TESTIS_Rat1.30089088
91TTF2_22483619_ChIP-Seq_HELA_Human1.29561836
92NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.28559924
93KDM2B_26808549_Chip-Seq_SUP-B15_Human1.28295165
94CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.27975176
95TP63_19390658_ChIP-ChIP_HaCaT_Human1.27294195
96CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.27184756
97THAP11_20581084_ChIP-Seq_MESCs_Mouse1.26412549
98* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.26264902
99VDR_21846776_ChIP-Seq_THP-1_Human1.25301433
100E2F1_21310950_ChIP-Seq_MCF-7_Human1.25060438
101CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.24573459
102* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.24238175
103* MYB_26560356_Chip-Seq_TH1_Human1.23654308
104* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.23017132
105RUNX1_22412390_ChIP-Seq_EML_Mouse1.22771525
106TFEB_21752829_ChIP-Seq_HELA_Human1.22046766
107TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21682207
108GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.20395819
109* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.20302606
110PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.19916267
111HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.18676115
112POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.18147828
113KDM2B_26808549_Chip-Seq_DND41_Human1.17527024
114RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.17247570
115NANOG_18555785_ChIP-Seq_MESCs_Mouse1.17213110
116TCF7_22412390_ChIP-Seq_EML_Mouse1.17196005
117AR_21909140_ChIP-Seq_LNCAP_Human1.17185037
118STAT3_1855785_ChIP-Seq_MESCs_Mouse1.16086978
119EGR1_23403033_ChIP-Seq_LIVER_Mouse1.15986908
120VDR_24763502_ChIP-Seq_THP-1_Human1.15323064
121* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.15089499
122THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.14486636
123POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.14028480
124* MAF_26560356_Chip-Seq_TH2_Human1.13607744
125* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.13255321
126MYCN_18555785_ChIP-Seq_MESCs_Mouse1.12902649
127CLOCK_20551151_ChIP-Seq_293T_Human1.12577716
128MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.10620262
129MYC_18940864_ChIP-ChIP_HL60_Human1.08176026
130STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.08169025
131SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.07958109
132UTX_26944678_Chip-Seq_JUKART_Human1.07228803
133P68_20966046_ChIP-Seq_HELA_Human1.06833709
134SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.06237770
135CTCF_27219007_Chip-Seq_ERYTHROID_Human1.06035423
136* NCOR1_26117541_ChIP-Seq_K562_Human1.04721577
137NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.03309378
138FOXM1_23109430_ChIP-Seq_U2OS_Human1.02052261
139P300_27058665_Chip-Seq_ZR-75-30cells_Human1.01327981
140CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.01251372
141MAF_26560356_Chip-Seq_TH1_Human1.01083350
142MYC_22102868_ChIP-Seq_BL_Human1.00768747
143RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.00314816
144KDM5A_27292631_Chip-Seq_BREAST_Human0.99541197
145IRF1_19129219_ChIP-ChIP_H3396_Human0.97917137
146EGR1_19374776_ChIP-ChIP_THP-1_Human0.97677121
147NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.96987552
148BRD4_27068464_Chip-Seq_AML-cells_Mouse0.96620773
149STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.96151366
150YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.94836872
151ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.94698584
152CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.94267346
153BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.91759195
154PU.1_20513432_ChIP-Seq_Bcells_Mouse0.88420624

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.34371658
2MP0002877_abnormal_melanocyte_morpholog3.04553224
3MP0003705_abnormal_hypodermis_morpholog3.03717240
4MP0005451_abnormal_body_composition2.91429183
5MP0003724_increased_susceptibility_to2.62902946
6MP0002396_abnormal_hematopoietic_system2.61708290
7MP0005671_abnormal_response_to2.61218394
8MP0005058_abnormal_lysosome_morphology2.59665684
9MP0003566_abnormal_cell_adhesion2.56036189
10MP0009785_altered_susceptibility_to2.48595291
11MP0003693_abnormal_embryo_hatching2.42812180
12MP0003191_abnormal_cellular_cholesterol2.40180196
13MP0008058_abnormal_DNA_repair2.33608324
14MP0001849_ear_inflammation2.30993554
15MP0005075_abnormal_melanosome_morpholog2.28686712
16MP0009840_abnormal_foam_cell2.27895909
17* MP0003763_abnormal_thymus_physiology2.27243976
18MP0003806_abnormal_nucleotide_metabolis2.13786765
19MP0010234_abnormal_vibrissa_follicle2.12767899
20MP0002148_abnormal_hypersensitivity_rea2.12004824
21MP0000685_abnormal_immune_system2.10598613
22MP0002132_abnormal_respiratory_system2.05913415
23MP0000490_abnormal_crypts_of2.03741494
24MP0005174_abnormal_tail_pigmentation2.02267947
25* MP0005025_abnormal_response_to2.00330038
26MP0008007_abnormal_cellular_replicative1.94637036
27MP0010094_abnormal_chromosome_stability1.87899742
28MP0006292_abnormal_olfactory_placode1.87359771
29MP0002796_impaired_skin_barrier1.85987463
30MP0003436_decreased_susceptibility_to1.84231164
31MP0001800_abnormal_humoral_immune1.81094613
32MP0000015_abnormal_ear_pigmentation1.79921984
33MP0002419_abnormal_innate_immunity1.79106237
34MP0005000_abnormal_immune_tolerance1.79048858
35MP0004185_abnormal_adipocyte_glucose1.78864838
36MP0005501_abnormal_skin_physiology1.74452363
37MP0002452_abnormal_antigen_presenting1.74247997
38MP0002723_abnormal_immune_serum1.73797860
39MP0009333_abnormal_splenocyte_physiolog1.73064408
40MP0003453_abnormal_keratinocyte_physiol1.71734393
41* MP0002420_abnormal_adaptive_immunity1.70394724
42* MP0001819_abnormal_immune_cell1.68640922
43MP0009379_abnormal_foot_pigmentation1.67626755
44MP0001790_abnormal_immune_system1.67236725
45MP0005387_immune_system_phenotype1.67236725
46* MP0002398_abnormal_bone_marrow1.65787932
47MP0001986_abnormal_taste_sensitivity1.65078029
48MP0001188_hyperpigmentation1.62832960
49MP0004808_abnormal_hematopoietic_stem1.62083533
50MP0003186_abnormal_redox_activity1.60651080
51MP0005257_abnormal_intraocular_pressure1.60373695
52MP0002095_abnormal_skin_pigmentation1.58714981
53MP0005464_abnormal_platelet_physiology1.58317386
54MP0009697_abnormal_copulation1.57006248
55MP0001853_heart_inflammation1.55679796
56MP0008057_abnormal_DNA_replication1.54782384
57MP0004233_abnormal_muscle_weight1.54368418
58MP0000372_irregular_coat_pigmentation1.53829483
59MP0004147_increased_porphyrin_level1.53093400
60MP0003111_abnormal_nucleus_morphology1.51265298
61MP0005076_abnormal_cell_differentiation1.51083319
62MP0002166_altered_tumor_susceptibility1.49920542
63* MP0000689_abnormal_spleen_morphology1.49455867
64* MP0000716_abnormal_immune_system1.48537354
65MP0001545_abnormal_hematopoietic_system1.48168656
66MP0005397_hematopoietic_system_phenotyp1.48168656
67MP0008438_abnormal_cutaneous_collagen1.47985066
68MP0003786_premature_aging1.46827756
69MP0004272_abnormal_basement_membrane1.45141303
70MP0000465_gastrointestinal_hemorrhage1.42589335
71MP0010155_abnormal_intestine_physiology1.41188218
72MP0002405_respiratory_system_inflammati1.41129198
73MP0003077_abnormal_cell_cycle1.39814596
74* MP0002722_abnormal_immune_system1.39441885
75MP0000537_abnormal_urethra_morphology1.38481522
76MP0001873_stomach_inflammation1.37434991
77* MP0002429_abnormal_blood_cell1.37239968
78MP0010030_abnormal_orbit_morphology1.37101305
79MP0004858_abnormal_nervous_system1.35622045
80MP0000681_abnormal_thyroid_gland1.34521007
81MP0004947_skin_inflammation1.33431729
82MP0000566_synostosis1.31919469
83MP0000678_abnormal_parathyroid_gland1.31275669
84MP0001730_embryonic_growth_arrest1.31053103
85MP0010352_gastrointestinal_tract_polyps1.29459843
86MP0002876_abnormal_thyroid_physiology1.27407494
87MP0005083_abnormal_biliary_tract1.27128913
88MP0003300_gastrointestinal_ulcer1.26696947
89MP0005023_abnormal_wound_healing1.25366748
90MP0009278_abnormal_bone_marrow1.25103199
91MP0002006_tumorigenesis1.24570121
92MP0000350_abnormal_cell_proliferation1.24341774
93MP0003091_abnormal_cell_migration1.23315461
94MP0003315_abnormal_perineum_morphology1.22879192
95MP0004381_abnormal_hair_follicle1.21125130
96MP0003136_yellow_coat_color1.20882163
97MP0002060_abnormal_skin_morphology1.17646261
98* MP0001845_abnormal_inflammatory_respons1.16577115
99MP0006054_spinal_hemorrhage1.13321890
100MP0001216_abnormal_epidermal_layer1.11746376
101MP0003303_peritoneal_inflammation1.11513367
102MP0004782_abnormal_surfactant_physiolog1.10767448
103* MP0008469_abnormal_protein_level1.10743310
104MP0003866_abnormal_defecation1.10586715
105MP0004957_abnormal_blastocyst_morpholog1.08517214
106MP0002009_preneoplasia1.07935239
107MP0005623_abnormal_meninges_morphology1.07392362
108MP0004264_abnormal_extraembryonic_tissu1.06278368
109* MP0000703_abnormal_thymus_morphology1.05205408
110MP0001764_abnormal_homeostasis1.03583407
111MP0002933_joint_inflammation1.03291982
112MP0002019_abnormal_tumor_incidence1.03042669
113MP0005084_abnormal_gallbladder_morpholo1.02026831
114* MP0002080_prenatal_lethality1.01355025
115MP0006082_CNS_inflammation1.01097297
116MP0003943_abnormal_hepatobiliary_system1.00829070
117MP0009053_abnormal_anal_canal1.00575280
118MP0000358_abnormal_cell_content/0.99641541
119MP0005621_abnormal_cell_physiology0.99135295
120MP0005409_darkened_coat_color0.96094198
121MP0004510_myositis0.94623713
122MP0000750_abnormal_muscle_regeneration0.93682946
123MP0001533_abnormal_skeleton_physiology0.93679800
124MP0001542_abnormal_bone_strength0.93397454
125MP0003828_pulmonary_edema0.90741121
126MP0003448_altered_tumor_morphology0.90541014
127MP0002998_abnormal_bone_remodeling0.90328969
128MP0002254_reproductive_system_inflammat0.90265141
129MP0001727_abnormal_embryo_implantation0.89887058
130MP0006035_abnormal_mitochondrial_morpho0.88481058
131MP0000343_altered_response_to0.88055805
132MP0005165_increased_susceptibility_to0.87560518
133MP0009764_decreased_sensitivity_to0.87008815
134MP0003075_altered_response_to0.86719534
135MP0005384_cellular_phenotype0.86587699
136MP0001119_abnormal_female_reproductive0.85156822
137MP0000858_altered_metastatic_potential0.84400072
138MP0000371_diluted_coat_color0.82674766
139* MP0000313_abnormal_cell_death0.82655649
140MP0003656_abnormal_erythrocyte_physiolo0.82148117
141MP0003221_abnormal_cardiomyocyte_apopto0.81983407
142MP0009931_abnormal_skin_appearance0.81690030
143MP0002089_abnormal_postnatal_growth/wei0.80857091
144MP0000733_abnormal_muscle_development0.80108046
145MP0001186_pigmentation_phenotype0.80098299
146MP0002086_abnormal_extraembryonic_tissu0.78844940
147MP0002075_abnormal_coat/hair_pigmentati0.78486446
148MP0002277_abnormal_respiratory_mucosa0.77478308
149MP0000627_abnormal_mammary_gland0.76861930
150MP0005666_abnormal_adipose_tissue0.76807766
151MP0001243_abnormal_dermal_layer0.76763776
152MP0008932_abnormal_embryonic_tissue0.75464260
153MP0005390_skeleton_phenotype0.72168291
154MP0008260_abnormal_autophagy0.72159017
155MP0003941_abnormal_skin_development0.68322132
156MP0005503_abnormal_tendon_morphology0.68310004
157MP0002938_white_spotting0.65743587
158MP0002163_abnormal_gland_morphology0.64597299
159MP0005670_abnormal_white_adipose0.64343755
160MP0003718_maternal_effect0.63182522

Predicted human phenotypes

RankGene SetZ-score
1Type I transferrin isoform profile (HP:0003642)4.78557303
2Reduced antithrombin III activity (HP:0001976)4.46604521
3Aplastic anemia (HP:0001915)3.89066069
4Premature rupture of membranes (HP:0001788)3.66317635
5Abnormal protein glycosylation (HP:0012346)3.44227562
6Abnormal glycosylation (HP:0012345)3.44227562
7Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.44227562
8Abnormal protein N-linked glycosylation (HP:0012347)3.44227562
9Vertebral compression fractures (HP:0002953)3.42041046
10Chromosomal breakage induced by crosslinking agents (HP:0003221)3.21736742
11Petechiae (HP:0000967)3.15829833
12Abnormality of the distal phalanges of the toes (HP:0010182)3.13931743
13Thrombocytosis (HP:0001894)3.11757950
14Reticulocytopenia (HP:0001896)3.04793130
15Chromsome breakage (HP:0040012)3.00506379
16Achilles tendon contracture (HP:0001771)2.94802743
17Abnormality of the heme biosynthetic pathway (HP:0010472)2.88114572
18Recurrent abscess formation (HP:0002722)2.87186311
19Myositis (HP:0100614)2.82876347
20Elevated erythrocyte sedimentation rate (HP:0003565)2.82622495
21Hyperacusis (HP:0010780)2.80623026
22Abnormal number of erythroid precursors (HP:0012131)2.77879434
23Distal lower limb muscle weakness (HP:0009053)2.76430503
24Rough bone trabeculation (HP:0100670)2.73362889
25IgM deficiency (HP:0002850)2.69585621
26Short nail (HP:0001799)2.63728586
27Abnormality of liposaccharide metabolism (HP:0010968)2.62938993
28Abnormality of glycosphingolipid metabolism (HP:0004343)2.62938993
29Abnormality of glycolipid metabolism (HP:0010969)2.62938993
30Trismus (HP:0000211)2.62707340
31Increased connective tissue (HP:0009025)2.62358296
32Distal lower limb amyotrophy (HP:0008944)2.61548147
33Prolonged bleeding time (HP:0003010)2.59537383
34Abnormality of the Achilles tendon (HP:0005109)2.56795950
35Ragged-red muscle fibers (HP:0003200)2.54353369
36Eczematoid dermatitis (HP:0000976)2.53849716
37Abnormality of cells of the erythroid lineage (HP:0012130)2.47034728
38Abnormality of T cell physiology (HP:0011840)2.43868545
39Abnormality of the prostate (HP:0008775)2.43146371
40Pancytopenia (HP:0001876)2.41360544
41Selective tooth agenesis (HP:0001592)2.41173507
42Exertional dyspnea (HP:0002875)2.37755594
43Reduced subcutaneous adipose tissue (HP:0003758)2.36592470
44Recurrent bacterial skin infections (HP:0005406)2.34464406
45Clubbing of toes (HP:0100760)2.34221988
46Osteolytic defects of the hand bones (HP:0009699)2.33889624
47Osteolytic defects of the phalanges of the hand (HP:0009771)2.33889624
48Nonimmune hydrops fetalis (HP:0001790)2.33530143
49Type 2 muscle fiber atrophy (HP:0003554)2.33450567
50Progressive muscle weakness (HP:0003323)2.33285435
51Abnormal delayed hypersensitivity skin test (HP:0002963)2.31946984
52Axonal loss (HP:0003447)2.29795641
53Abnormality of DNA repair (HP:0003254)2.29655148
54Abnormality of the preputium (HP:0100587)2.28723700
55Generalized aminoaciduria (HP:0002909)2.28575384
56Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.27422608
57Hepatic necrosis (HP:0002605)2.27175403
58Renal cortical cysts (HP:0000803)2.24512987
59Panhypogammaglobulinemia (HP:0003139)2.20803067
60Muscle fiber atrophy (HP:0100295)2.18330355
61Hypertensive crisis (HP:0100735)2.18001715
62Meningitis (HP:0001287)2.17835846
63Microcytic anemia (HP:0001935)2.16990977
64Protrusio acetabuli (HP:0003179)2.16490437
65Cellulitis (HP:0100658)2.14444106
66Epistaxis (HP:0000421)2.13509640
67Hepatocellular necrosis (HP:0001404)2.13009768
68Centrally nucleated skeletal muscle fibers (HP:0003687)2.11892782
69True hermaphroditism (HP:0010459)2.11633310
70Bone marrow hypocellularity (HP:0005528)2.11277398
71Fragile skin (HP:0001030)2.11177202
72Elbow flexion contracture (HP:0002987)2.10112503
73Aplasia/Hypoplasia of the sacrum (HP:0008517)2.09152931
74Meckel diverticulum (HP:0002245)2.08306103
75Abnormality of the umbilical cord (HP:0010881)2.07622024
76Difficulty climbing stairs (HP:0003551)2.06924025
77Abnormal trabecular bone morphology (HP:0100671)2.06777484
7811 pairs of ribs (HP:0000878)2.06579898
793-Methylglutaconic aciduria (HP:0003535)2.06571905
80Generalized amyotrophy (HP:0003700)2.06391868
81Myelodysplasia (HP:0002863)2.05792624
82Distal upper limb amyotrophy (HP:0007149)2.05471285
83Upper limb amyotrophy (HP:0009129)2.05471285
84Abnormal spermatogenesis (HP:0008669)2.05039702
85Thyroid-stimulating hormone excess (HP:0002925)2.04461120
86Hepatosplenomegaly (HP:0001433)2.03376836
87Abnormality of chromosome stability (HP:0003220)2.03274227
88Hypothermia (HP:0002045)2.02894806
89Long palpebral fissure (HP:0000637)2.02641635
90Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.01546092
91Mediastinal lymphadenopathy (HP:0100721)2.00858986
92Abnormality of the ileum (HP:0001549)2.00394966
93Neutropenia (HP:0001875)1.99954381
94Patchy hypopigmentation of hair (HP:0011365)1.99926775
95Atrophic scars (HP:0001075)1.99617714
96Aplasia/Hypoplasia of the uvula (HP:0010293)1.99031219
97Hypokinesia (HP:0002375)1.98129091
98Spinal rigidity (HP:0003306)1.97657264
99Microvesicular hepatic steatosis (HP:0001414)1.97304597
100Recurrent fungal infections (HP:0002841)1.96218337
101Abnormal gallbladder physiology (HP:0012438)1.95611682
102Cholecystitis (HP:0001082)1.95611682
103IgG deficiency (HP:0004315)1.94839087
104Vacuolated lymphocytes (HP:0001922)1.94684905
105Chronic otitis media (HP:0000389)1.94206642
106Recurrent viral infections (HP:0004429)1.94047351
107Renal Fanconi syndrome (HP:0001994)1.93767898
108Retrobulbar optic neuritis (HP:0100654)1.93232758
109Optic neuritis (HP:0100653)1.93232758
110Increased serum ferritin (HP:0003281)1.93109145
111Poor head control (HP:0002421)1.92831726
112Prolonged neonatal jaundice (HP:0006579)1.92084906
113Polygenic inheritance (HP:0010982)1.91719382
114Abnormality of T cells (HP:0002843)1.91632712
115Ulnar bowing (HP:0003031)1.91486162
116Flattened epiphyses (HP:0003071)1.91382676
117Obstructive lung disease (HP:0006536)1.90020518
118Chronic obstructive pulmonary disease (HP:0006510)1.90020518
119Multiple lipomas (HP:0001012)1.89111236
120Orchitis (HP:0100796)1.88478555
121Encephalitis (HP:0002383)1.87677807
122Increased hepatocellular lipid droplets (HP:0006565)1.87518437
123Absent rod-and cone-mediated responses on ERG (HP:0007688)1.87500365
124Abnormality of macrophages (HP:0004311)1.85642349
125Deviation of the thumb (HP:0009603)1.85641611
126Upper motor neuron abnormality (HP:0002127)1.84216160
127Insomnia (HP:0100785)1.83748898
128Lymphoma (HP:0002665)1.83641359
129Pancreatic fibrosis (HP:0100732)1.83193447
130Abnormality of the renal collecting system (HP:0004742)1.82508892
131Micronodular cirrhosis (HP:0001413)1.82497892
132Poikiloderma (HP:0001029)1.82492263
133Recurrent cutaneous fungal infections (HP:0011370)1.81370808
134Chronic mucocutaneous candidiasis (HP:0002728)1.81370808
135Broad distal phalanx of finger (HP:0009836)1.81295627
136Microretrognathia (HP:0000308)1.80388630
137Cerebral palsy (HP:0100021)1.79823987
138Pallor (HP:0000980)1.79403176
139Recurrent pneumonia (HP:0006532)1.77872830
140Agammaglobulinemia (HP:0004432)1.77814054
141Dry hair (HP:0011359)1.77323105
142Basal ganglia calcification (HP:0002135)1.76418995
143White forelock (HP:0002211)1.76334335
144Recurrent skin infections (HP:0001581)1.75860723
145Hyperparathyroidism (HP:0000843)1.75729833
146Blue sclerae (HP:0000592)1.75425699
147Proximal placement of thumb (HP:0009623)1.74582374
148Short middle phalanx of the 5th finger (HP:0004220)1.74260083
149Prostate neoplasm (HP:0100787)1.73068246
150Hypergonadotropic hypogonadism (HP:0000815)1.71961243
151Granulocytopenia (HP:0001913)1.71190104
152Increased serum lactate (HP:0002151)1.70926317
153Mitochondrial inheritance (HP:0001427)1.70679248
154Impaired platelet aggregation (HP:0003540)1.70494452
155Abnormal platelet function (HP:0011869)1.70494452
156Squamous cell carcinoma (HP:0002860)1.70465137
157Cervical subluxation (HP:0003308)1.69538428
158Entropion (HP:0000621)1.69293894
159Lipid accumulation in hepatocytes (HP:0006561)1.68848414
160Nail dystrophy (HP:0008404)1.68377970
161Azoospermia (HP:0000027)1.68321994
162Thoracic kyphosis (HP:0002942)1.66551097
163Progressive neurologic deterioration (HP:0002344)1.66532401
164Increased cerebral lipofuscin (HP:0011813)1.66402608
165Interstitial pulmonary disease (HP:0006530)1.65967100
166Natal tooth (HP:0000695)1.65501273
167Abnormality of the thoracic spine (HP:0100711)1.65184717
168Dysostosis multiplex (HP:0000943)1.64283830
169Myocardial infarction (HP:0001658)1.63254993
170Bone pain (HP:0002653)1.62480761
171Genu recurvatum (HP:0002816)1.61059110
172Abnormality of carpal bone ossification (HP:0006257)1.60372914
173Broad face (HP:0000283)1.60212253
174Patellar dislocation (HP:0002999)1.59409788
175Flat acetabular roof (HP:0003180)1.59289801
176Purpura (HP:0000979)1.57057739
177Hypertriglyceridemia (HP:0002155)1.55584936
178Spinal cord compression (HP:0002176)1.55334204
179Decreased activity of mitochondrial respiratory chain (HP:0008972)1.55011389
180Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.55011389
181Abnormalities of placenta or umbilical cord (HP:0001194)1.54661040
182Abnormality of oral frenula (HP:0000190)1.53636161
183Abnormality of the tricuspid valve (HP:0001702)1.53005778
184Abnormal ossification of hand bones (HP:0005921)1.52972220
185Back pain (HP:0003418)1.52841768
186Short clavicles (HP:0000894)1.52383144
187Single umbilical artery (HP:0001195)1.52345629
188Abnormality of the fetal cardiovascular system (HP:0010948)1.52345629
189Abnormal umbilical cord blood vessels (HP:0011403)1.52345629

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK23.39118823
2TNIK3.07867250
3EPHA22.93959289
4SMG12.93691039
5STK162.91569187
6TRIB32.87379588
7ERN12.85390016
8TESK12.83912152
9NME22.68896028
10ZAK2.36238154
11MKNK22.30952564
12NLK2.29991612
13VRK22.28308733
14TXK2.27026352
15IRAK32.27016196
16ARAF2.21344341
17PRPF4B2.20700177
18TEC2.18569910
19IRAK42.17796800
20EIF2AK32.07706041
21PIM22.04187968
22PAK42.02510768
23KIT2.01197802
24MKNK11.97546434
25MUSK1.94435030
26SRPK11.85425093
27MAP4K11.84741991
28MST1R1.72267857
29MAP3K141.71861182
30IKBKE1.69283016
31MAP3K111.69214875
32SIK11.67801534
33JAK31.64675321
34LIMK11.62222806
35BTK1.57419171
36BLK1.53656383
37BRSK21.53052100
38ICK1.51904796
39IKBKB1.51500379
40ZAP701.51383891
41TLK11.49256914
42FLT31.49087559
43WEE11.48152047
44BUB11.43250136
45BCKDK1.42495551
46SCYL21.41630038
47TBK11.40401458
48EIF2AK11.37533452
49VRK11.30511551
50MAP2K31.29030516
51EIF2AK21.28502120
52KDR1.25849877
53EPHB11.17455923
54PIM11.15680432
55PBK1.13536148
56NEK91.12930596
57PTK21.11742358
58MAP3K81.11138178
59PLK41.10189817
60TYK21.09670140
61LMTK21.07518749
62MAP3K101.07058467
63TTN1.04259588
64ABL21.04056143
65SIK31.03637841
66YES11.00086814
67ILK1.00025126
68CCNB10.98252530
69BRAF0.97781808
70IRAK20.97429232
71PKN20.95101270
72ADRBK20.95063052
73RPS6KA40.94582423
74MYLK0.92383028
75ATR0.91587418
76CDK80.91182837
77CSF1R0.90524945
78CHUK0.90163812
79ACVR1B0.89862134
80CDK70.88084103
81CDC70.87975612
82PTK60.87868133
83TRPM70.87509163
84STK40.86472684
85LYN0.86075704
86MOS0.85950639
87LRRK20.84685828
88TAOK10.83345352
89TGFBR20.82213883
90BMX0.80747417
91LATS20.80671707
92* AURKA0.79705993
93TIE10.79161679
94STK240.78667178
95PAK10.78581673
96NEK10.77451119
97SYK0.77191730
98DYRK30.76227207
99CLK10.74919191
100NUAK10.74883685
101TAOK30.74616389
102EEF2K0.73830320
103PRKD20.70694678
104AURKB0.70420832
105CDK40.69502566
106CDK120.67332517
107PDGFRA0.66945611
108RAF10.66446098
109RIPK10.66168900
110BMPR1B0.65186225
111DAPK10.62378476
112MAP3K130.61593280
113MAP3K30.61181467
114MATK0.61007035
115DAPK30.60724950
116TGFBR10.60389299
117MET0.58715778
118ERBB30.58499192
119RPS6KA60.57222754
120MAPKAPK50.56250616
121MAP3K120.56049246
122ERBB40.56005716
123FGFR40.55125456
124LCK0.54761684
125PINK10.54632584
126MTOR0.53413804
127PASK0.52902449
128RPS6KB20.50727211
129PRKCI0.50714157
130CSK0.50431817
131RPS6KA50.50381210
132BMPR20.49707194
133* PLK10.49317456
134MAP2K60.48297587
135PRKG20.48274694
136CHEK20.48054529
137CSNK2A10.47938367
138GRK60.47590335
139MARK30.47163946
140SGK20.47130744
141IRAK10.46220336
142RPS6KC10.45680800
143RPS6KL10.45680800
144PIK3CG0.45386700
145NEK20.43398881
146CSNK1G30.43378791
147TAOK20.43013575
148MAPKAPK20.42083946
149STK100.41517152
150CDK190.40577596
151BRSK10.40312301
152TNK20.40302322
153AKT20.40269852
154MAPKAPK30.39192307
155KSR20.38825316
156CDK30.37727115
157MAPK110.37071215
158PDPK10.35807914
159CSNK1A1L0.33604579
160CDK60.33058443

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.80445845
2Homologous recombination_Homo sapiens_hsa034402.83053770
3Ribosome_Homo sapiens_hsa030102.80584419
4Mismatch repair_Homo sapiens_hsa034302.70266845
5Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.66544363
6Base excision repair_Homo sapiens_hsa034102.64553604
7RNA polymerase_Homo sapiens_hsa030202.30591840
8Pyrimidine metabolism_Homo sapiens_hsa002402.20486173
9Proteasome_Homo sapiens_hsa030502.09593077
10Fanconi anemia pathway_Homo sapiens_hsa034601.93525558
11Nucleotide excision repair_Homo sapiens_hsa034201.92212332
12Bladder cancer_Homo sapiens_hsa052191.89255040
13Protein export_Homo sapiens_hsa030601.89165173
14Primary immunodeficiency_Homo sapiens_hsa053401.79412214
15Biosynthesis of amino acids_Homo sapiens_hsa012301.77376403
16Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.71770240
17One carbon pool by folate_Homo sapiens_hsa006701.69439850
18Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.65568426
19Other glycan degradation_Homo sapiens_hsa005111.62612280
20Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.60173036
21Spliceosome_Homo sapiens_hsa030401.57307143
22Non-homologous end-joining_Homo sapiens_hsa034501.57000448
23Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.55256330
24Intestinal immune network for IgA production_Homo sapiens_hsa046721.54559374
25Chronic myeloid leukemia_Homo sapiens_hsa052201.53373433
26NF-kappa B signaling pathway_Homo sapiens_hsa040641.53191174
27Measles_Homo sapiens_hsa051621.49100993
28Central carbon metabolism in cancer_Homo sapiens_hsa052301.47770122
292-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.47554318
30Basal transcription factors_Homo sapiens_hsa030221.43531415
31* Herpes simplex infection_Homo sapiens_hsa051681.41153950
32RNA degradation_Homo sapiens_hsa030181.41061827
33Allograft rejection_Homo sapiens_hsa053301.40258304
34Pancreatic cancer_Homo sapiens_hsa052121.38500890
35Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.37600014
36Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.36744952
37Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.35853913
38Cell cycle_Homo sapiens_hsa041101.32642231
39Folate biosynthesis_Homo sapiens_hsa007901.31386416
40Hematopoietic cell lineage_Homo sapiens_hsa046401.25343350
41* RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.24943983
42Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.24892014
43Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.23988697
44Purine metabolism_Homo sapiens_hsa002301.23082540
45Leishmaniasis_Homo sapiens_hsa051401.21658747
46Carbon metabolism_Homo sapiens_hsa012001.20491999
47Antigen processing and presentation_Homo sapiens_hsa046121.19606286
48Arachidonic acid metabolism_Homo sapiens_hsa005901.19322455
49Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.17063002
50p53 signaling pathway_Homo sapiens_hsa041151.16349971
51Non-small cell lung cancer_Homo sapiens_hsa052231.16004158
52Lysosome_Homo sapiens_hsa041421.14026298
53Salmonella infection_Homo sapiens_hsa051321.12843109
54Glycosaminoglycan degradation_Homo sapiens_hsa005311.08355557
55Legionellosis_Homo sapiens_hsa051341.08248880
56Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.07419866
57Sulfur relay system_Homo sapiens_hsa041221.05148297
58Graft-versus-host disease_Homo sapiens_hsa053321.01813709
59Vibrio cholerae infection_Homo sapiens_hsa051100.98004468
60N-Glycan biosynthesis_Homo sapiens_hsa005100.97306872
61Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.96918790
62RNA transport_Homo sapiens_hsa030130.96113608
63Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.95808873
64Drug metabolism - other enzymes_Homo sapiens_hsa009830.95695277
65Pentose and glucuronate interconversions_Homo sapiens_hsa000400.95517144
66Jak-STAT signaling pathway_Homo sapiens_hsa046300.95284611
67Endometrial cancer_Homo sapiens_hsa052130.94459546
68Asthma_Homo sapiens_hsa053100.94385319
69Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.94043591
70Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.93015523
71Transcriptional misregulation in cancer_Homo sapiens_hsa052020.89333740
72Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.88581945
73SNARE interactions in vesicular transport_Homo sapiens_hsa041300.88476236
74Autoimmune thyroid disease_Homo sapiens_hsa053200.87640680
75* Toll-like receptor signaling pathway_Homo sapiens_hsa046200.86535476
76Endocytosis_Homo sapiens_hsa041440.82019652
77Leukocyte transendothelial migration_Homo sapiens_hsa046700.80624658
78Influenza A_Homo sapiens_hsa051640.79977003
79Proteoglycans in cancer_Homo sapiens_hsa052050.78118145
80Malaria_Homo sapiens_hsa051440.73766517
81Vitamin digestion and absorption_Homo sapiens_hsa049770.73508913
82Pentose phosphate pathway_Homo sapiens_hsa000300.73399610
83NOD-like receptor signaling pathway_Homo sapiens_hsa046210.71353027
84Galactose metabolism_Homo sapiens_hsa000520.69942934
85Epstein-Barr virus infection_Homo sapiens_hsa051690.68509019
86Notch signaling pathway_Homo sapiens_hsa043300.67537881
87VEGF signaling pathway_Homo sapiens_hsa043700.67232831
88Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.66576591
89Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.65386745
90Acute myeloid leukemia_Homo sapiens_hsa052210.65339583
91Focal adhesion_Homo sapiens_hsa045100.64921781
92Pertussis_Homo sapiens_hsa051330.64027932
93Fatty acid elongation_Homo sapiens_hsa000620.63508978
94Phagosome_Homo sapiens_hsa041450.62117995
95* Apoptosis_Homo sapiens_hsa042100.61744673
96Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.61361088
97Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.61081132
98Thyroid cancer_Homo sapiens_hsa052160.59963771
99Prion diseases_Homo sapiens_hsa050200.59756468
100Viral myocarditis_Homo sapiens_hsa054160.58386154
101Staphylococcus aureus infection_Homo sapiens_hsa051500.58047149
102Glutathione metabolism_Homo sapiens_hsa004800.57493838
103Selenocompound metabolism_Homo sapiens_hsa004500.57378594
104Systemic lupus erythematosus_Homo sapiens_hsa053220.56641393
105Sphingolipid metabolism_Homo sapiens_hsa006000.56437490
106Colorectal cancer_Homo sapiens_hsa052100.54969036
107Regulation of actin cytoskeleton_Homo sapiens_hsa048100.54348511
108Regulation of autophagy_Homo sapiens_hsa041400.54212933
109Renal cell carcinoma_Homo sapiens_hsa052110.52994994
110Insulin signaling pathway_Homo sapiens_hsa049100.52543005
111Steroid hormone biosynthesis_Homo sapiens_hsa001400.50349335
112Prostate cancer_Homo sapiens_hsa052150.50255479
113* Hepatitis B_Homo sapiens_hsa051610.50239516
114Cyanoamino acid metabolism_Homo sapiens_hsa004600.50187046
115B cell receptor signaling pathway_Homo sapiens_hsa046620.49704057
116Shigellosis_Homo sapiens_hsa051310.48313785
117Neurotrophin signaling pathway_Homo sapiens_hsa047220.48275056
118MicroRNAs in cancer_Homo sapiens_hsa052060.47932865
119Toxoplasmosis_Homo sapiens_hsa051450.47614962
120Caffeine metabolism_Homo sapiens_hsa002320.46429953
121HTLV-I infection_Homo sapiens_hsa051660.46177716
122Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.45753448
123Glioma_Homo sapiens_hsa052140.45648696
124Metabolic pathways_Homo sapiens_hsa011000.45243411
125HIF-1 signaling pathway_Homo sapiens_hsa040660.45139051
126Alcoholism_Homo sapiens_hsa050340.45035978
127Osteoclast differentiation_Homo sapiens_hsa043800.44469555
128Sphingolipid signaling pathway_Homo sapiens_hsa040710.44298105
129Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.43323141
130Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.42143393
131Small cell lung cancer_Homo sapiens_hsa052220.41874170
132Peroxisome_Homo sapiens_hsa041460.41750101
133Maturity onset diabetes of the young_Homo sapiens_hsa049500.41573506
134Viral carcinogenesis_Homo sapiens_hsa052030.41199080
135AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.39710442
136Linoleic acid metabolism_Homo sapiens_hsa005910.36987987
137Hepatitis C_Homo sapiens_hsa051600.34764059
138Fructose and mannose metabolism_Homo sapiens_hsa000510.34552573
139Retinol metabolism_Homo sapiens_hsa008300.34279839
140Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.33977504
141beta-Alanine metabolism_Homo sapiens_hsa004100.33714790
142* TNF signaling pathway_Homo sapiens_hsa046680.32455094
143* Tuberculosis_Homo sapiens_hsa051520.31351339

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