FADS6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.62773413
2L-phenylalanine catabolic process (GO:0006559)7.62773413
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.15257040
4L-phenylalanine metabolic process (GO:0006558)7.15257040
5aromatic amino acid family catabolic process (GO:0009074)6.80085306
6tryptophan catabolic process (GO:0006569)6.08886798
7indole-containing compound catabolic process (GO:0042436)6.08886798
8indolalkylamine catabolic process (GO:0046218)6.08886798
9kynurenine metabolic process (GO:0070189)5.82642774
10bile acid biosynthetic process (GO:0006699)5.80002575
11tryptophan metabolic process (GO:0006568)5.72626901
12triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.70442361
13glyoxylate metabolic process (GO:0046487)5.38293646
14urea cycle (GO:0000050)5.33193146
15urea metabolic process (GO:0019627)5.33193146
16high-density lipoprotein particle remodeling (GO:0034375)5.22655742
17alpha-linolenic acid metabolic process (GO:0036109)5.22062999
18complement activation, alternative pathway (GO:0006957)5.10729599
19regulation of protein activation cascade (GO:2000257)5.04929712
20protein carboxylation (GO:0018214)5.01657264
21peptidyl-glutamic acid carboxylation (GO:0017187)5.01657264
22negative regulation of fibrinolysis (GO:0051918)5.01202083
23regulation of fibrinolysis (GO:0051917)4.97969740
24bile acid metabolic process (GO:0008206)4.97049587
25nitrogen cycle metabolic process (GO:0071941)4.92823329
26aromatic amino acid family metabolic process (GO:0009072)4.91686828
27cysteine metabolic process (GO:0006534)4.91564471
28sulfur amino acid catabolic process (GO:0000098)4.88663003
29tyrosine metabolic process (GO:0006570)4.75147406
30regulation of complement activation (GO:0030449)4.72249958
31serine family amino acid catabolic process (GO:0009071)4.66811106
32homocysteine metabolic process (GO:0050667)4.64683720
33behavioral response to nicotine (GO:0035095)4.59265275
34reverse cholesterol transport (GO:0043691)4.58561309
35alpha-amino acid catabolic process (GO:1901606)4.51744296
36coenzyme catabolic process (GO:0009109)4.50045855
37regulation of cholesterol esterification (GO:0010872)4.49047634
38fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.46219859
39plasma lipoprotein particle remodeling (GO:0034369)4.45724363
40protein-lipid complex remodeling (GO:0034368)4.45724363
41macromolecular complex remodeling (GO:0034367)4.45724363
42L-fucose catabolic process (GO:0042355)4.43496300
43fucose catabolic process (GO:0019317)4.43496300
44L-fucose metabolic process (GO:0042354)4.43496300
45regulation of triglyceride catabolic process (GO:0010896)4.42010682
46indolalkylamine metabolic process (GO:0006586)4.41748331
47amine catabolic process (GO:0009310)4.38221894
48cellular biogenic amine catabolic process (GO:0042402)4.38221894
49acylglycerol homeostasis (GO:0055090)4.36786600
50triglyceride homeostasis (GO:0070328)4.36786600
51glutamate metabolic process (GO:0006536)4.27090218
52amino-acid betaine metabolic process (GO:0006577)4.25123754
53phospholipid efflux (GO:0033700)4.24577362
54bile acid and bile salt transport (GO:0015721)4.20382557
55imidazole-containing compound metabolic process (GO:0052803)4.19975553
56cellular amino acid catabolic process (GO:0009063)4.15748112
57cellular ketone body metabolic process (GO:0046950)4.14302079
58cholesterol efflux (GO:0033344)4.13839370
59lysine catabolic process (GO:0006554)4.10496716
60lysine metabolic process (GO:0006553)4.10496716
61negative regulation of sterol transport (GO:0032372)4.05834047
62negative regulation of cholesterol transport (GO:0032375)4.05834047
63benzene-containing compound metabolic process (GO:0042537)4.02424178
64dicarboxylic acid biosynthetic process (GO:0043650)4.01538869
65cellular glucuronidation (GO:0052695)4.00350887
66plasma lipoprotein particle clearance (GO:0034381)3.97192330
67cellular modified amino acid catabolic process (GO:0042219)3.96452733
68drug catabolic process (GO:0042737)3.93271930
69ethanol oxidation (GO:0006069)3.87553124
70cornea development in camera-type eye (GO:0061303)3.87332627
71detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.85972221
72low-density lipoprotein particle remodeling (GO:0034374)3.84620306
73detection of light stimulus involved in sensory perception (GO:0050962)3.81627964
74detection of light stimulus involved in visual perception (GO:0050908)3.81627964
75regulation of bile acid biosynthetic process (GO:0070857)3.79110361
76cofactor catabolic process (GO:0051187)3.78242816
77arginine metabolic process (GO:0006525)3.77736286
78glycine metabolic process (GO:0006544)3.76361625
79serine family amino acid metabolic process (GO:0009069)3.74607112
80plasma lipoprotein particle assembly (GO:0034377)3.69507833
81fibrinolysis (GO:0042730)3.68487676
82platelet dense granule organization (GO:0060155)3.67652462
83NAD biosynthetic process (GO:0009435)3.65920708
84response to pheromone (GO:0019236)3.65357170
85very-low-density lipoprotein particle assembly (GO:0034379)3.63333173
86blood coagulation, intrinsic pathway (GO:0007597)3.61794723
87negative regulation of lipase activity (GO:0060192)3.61551639
88short-chain fatty acid metabolic process (GO:0046459)3.59873441
89carboxylic acid catabolic process (GO:0046395)3.58580737
90organic acid catabolic process (GO:0016054)3.58580737
91ketone body metabolic process (GO:1902224)3.58452185
92aldehyde catabolic process (GO:0046185)3.57844365
93uronic acid metabolic process (GO:0006063)3.56579109
94glucuronate metabolic process (GO:0019585)3.56579109
95serine family amino acid biosynthetic process (GO:0009070)3.55472116
96phospholipid homeostasis (GO:0055091)3.55296737
97complement activation, classical pathway (GO:0006958)3.54504330
98exogenous drug catabolic process (GO:0042738)3.52942841
99complement activation (GO:0006956)3.52142738
100nicotinamide nucleotide biosynthetic process (GO:0019359)3.52093444
101pyridine nucleotide biosynthetic process (GO:0019363)3.52093444
102cholesterol homeostasis (GO:0042632)3.51639788
103protein activation cascade (GO:0072376)3.51612259
104positive regulation of triglyceride lipase activity (GO:0061365)3.49151683
105positive regulation of lipoprotein lipase activity (GO:0051006)3.49151683
106acetyl-CoA metabolic process (GO:0006084)3.48120369
107opsonization (GO:0008228)3.47411771
108sterol homeostasis (GO:0055092)3.45363014
109gamma-aminobutyric acid transport (GO:0015812)3.42983258
110cytolysis (GO:0019835)3.41574073
111negative regulation of protein activation cascade (GO:2000258)3.41561353
112DNA deamination (GO:0045006)3.23274121
113positive regulation of fatty acid transport (GO:2000193)3.22054436
114mannosylation (GO:0097502)3.15073526
115respiratory chain complex IV assembly (GO:0008535)3.14296076
116regulation of hexokinase activity (GO:1903299)3.09349955
117regulation of glucokinase activity (GO:0033131)3.09349955
118transepithelial transport (GO:0070633)3.05819640
119S-adenosylmethionine metabolic process (GO:0046500)3.05611228
120regulation of cilium movement (GO:0003352)3.03423556
121sulfation (GO:0051923)3.01344910
122photoreceptor cell maintenance (GO:0045494)3.00219484
123epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.98650955
124cellular response to ATP (GO:0071318)2.96990406
125auditory receptor cell stereocilium organization (GO:0060088)2.95060588
126protein-cofactor linkage (GO:0018065)2.94871926
127water-soluble vitamin biosynthetic process (GO:0042364)2.89382214
128indole-containing compound metabolic process (GO:0042430)2.86495578
129positive regulation of icosanoid secretion (GO:0032305)2.84457316
130behavioral response to ethanol (GO:0048149)2.83668954
131positive regulation of prostaglandin secretion (GO:0032308)2.82067893
132cytochrome complex assembly (GO:0017004)2.81680993
133phosphatidylinositol acyl-chain remodeling (GO:0036149)2.80870017
134neuronal action potential (GO:0019228)2.80026175
135primary amino compound metabolic process (GO:1901160)2.77647378
136neuronal action potential propagation (GO:0019227)2.77504011
137serotonin metabolic process (GO:0042428)2.77153389
138retinal cone cell development (GO:0046549)2.75087591
139G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.74751826
140nucleobase catabolic process (GO:0046113)2.74472941
141C4-dicarboxylate transport (GO:0015740)2.72133193
142piRNA metabolic process (GO:0034587)2.72071187
143axoneme assembly (GO:0035082)2.72021178
144somite development (GO:0061053)2.71832660
145photoreceptor cell development (GO:0042461)2.70862689
146regulation of action potential (GO:0098900)2.65393963
147alkaloid metabolic process (GO:0009820)2.63017263
148drug metabolic process (GO:0017144)2.61471027
149regulation of guanylate cyclase activity (GO:0031282)2.61284201
150heme transport (GO:0015886)2.60847911
151protein complex biogenesis (GO:0070271)2.59656958
152oxidative demethylation (GO:0070989)2.59467789
153preassembly of GPI anchor in ER membrane (GO:0016254)2.58049422
154nephron tubule morphogenesis (GO:0072078)2.54077201
155nephron epithelium morphogenesis (GO:0072088)2.54077201
156proline transport (GO:0015824)2.53690366
157inner ear receptor stereocilium organization (GO:0060122)2.53397827
158reflex (GO:0060004)2.51900036
159cilium morphogenesis (GO:0060271)2.51537100
160parturition (GO:0007567)2.50938385
161phosphatidylserine acyl-chain remodeling (GO:0036150)2.50780070
162nonmotile primary cilium assembly (GO:0035058)2.49958512
163regulation of microtubule-based movement (GO:0060632)2.45739195
164epithelial cilium movement (GO:0003351)2.45162357
165pyrimidine nucleobase catabolic process (GO:0006208)2.44977606
166protein prenylation (GO:0018342)2.43434131
167prenylation (GO:0097354)2.43434131
168mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.43318938
169mitochondrial respiratory chain complex I assembly (GO:0032981)2.43318938
170NADH dehydrogenase complex assembly (GO:0010257)2.43318938
171male meiosis I (GO:0007141)2.41210006
172positive regulation of organic acid transport (GO:0032892)2.40529300
173positive regulation of guanylate cyclase activity (GO:0031284)2.39929766
174fucosylation (GO:0036065)2.39803509
175dopamine transport (GO:0015872)2.39216142
176protein localization to cilium (GO:0061512)2.38912480
177purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.38486282
1783-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.38486282
179mitochondrial respiratory chain complex assembly (GO:0033108)2.38104993
180quinone biosynthetic process (GO:1901663)2.38064920
181eye photoreceptor cell development (GO:0042462)2.35876928
182multicellular organism reproduction (GO:0032504)2.33165321
183rhodopsin mediated signaling pathway (GO:0016056)2.32968646

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.86807047
2RXR_22158963_ChIP-Seq_LIVER_Mouse7.04464589
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.08507980
4* PPARA_22158963_ChIP-Seq_LIVER_Mouse5.81849447
5LXR_22158963_ChIP-Seq_LIVER_Mouse5.60148255
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.68800714
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.00736992
8ZNF274_21170338_ChIP-Seq_K562_Hela3.72760686
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.68301718
10VDR_22108803_ChIP-Seq_LS180_Human3.51296325
11CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.14415861
12PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.13819239
13IGF1R_20145208_ChIP-Seq_DFB_Human2.42361715
14POU3F2_20337985_ChIP-ChIP_501MEL_Human2.38544117
15EZH2_22144423_ChIP-Seq_EOC_Human2.14419038
16CTBP2_25329375_ChIP-Seq_LNCAP_Human2.09544035
17FLI1_27457419_Chip-Seq_LIVER_Mouse2.06466340
18FUS_26573619_Chip-Seq_HEK293_Human1.88819538
19EWS_26573619_Chip-Seq_HEK293_Human1.88301553
20ER_23166858_ChIP-Seq_MCF-7_Human1.83966652
21HTT_18923047_ChIP-ChIP_STHdh_Human1.83832178
22TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.76621048
23EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.75660597
24HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.68436724
25PCGF2_27294783_Chip-Seq_ESCs_Mouse1.67490344
26FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.65405137
27CBP_20019798_ChIP-Seq_JUKART_Human1.62360351
28IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.62360351
29FOXA2_19822575_ChIP-Seq_HepG2_Human1.61378863
30SALL1_21062744_ChIP-ChIP_HESCs_Human1.61300491
31CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.55635721
32TP53_22573176_ChIP-Seq_HFKS_Human1.55131157
33FOXA1_27270436_Chip-Seq_PROSTATE_Human1.51589424
34FOXA1_25329375_ChIP-Seq_VCAP_Human1.51589424
35MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.50978798
36PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.46828292
37SOX2_19829295_ChIP-Seq_ESCs_Human1.45339086
38NANOG_19829295_ChIP-Seq_ESCs_Human1.45339086
39AR_25329375_ChIP-Seq_VCAP_Human1.44981646
40TCF4_23295773_ChIP-Seq_U87_Human1.44313077
41GBX2_23144817_ChIP-Seq_PC3_Human1.44135850
42GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.43663098
43TCF4_22108803_ChIP-Seq_LS180_Human1.42546514
44* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.40621319
45ETV2_25802403_ChIP-Seq_MESCs_Mouse1.40426340
46SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.40181488
47TAF15_26573619_Chip-Seq_HEK293_Human1.37578327
48FOXA1_21572438_ChIP-Seq_LNCaP_Human1.37572135
49MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.34720476
50KLF5_20875108_ChIP-Seq_MESCs_Mouse1.34676393
51PCGF2_27294783_Chip-Seq_NPCs_Mouse1.33640994
52MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.32044475
53E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.31940396
54NCOR_22424771_ChIP-Seq_293T_Human1.31705360
55SMAD3_21741376_ChIP-Seq_EPCs_Human1.30854263
56POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.28861503
57TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28861503
58BMI1_23680149_ChIP-Seq_NPCS_Mouse1.28096368
59HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.26525460
60MYC_18940864_ChIP-ChIP_HL60_Human1.25733238
61* GATA3_21878914_ChIP-Seq_MCF-7_Human1.25556125
62TOP2B_26459242_ChIP-Seq_MCF-7_Human1.24964486
63AR_20517297_ChIP-Seq_VCAP_Human1.22954570
64GATA1_22025678_ChIP-Seq_K562_Human1.22209575
65HNF4A_19822575_ChIP-Seq_HepG2_Human1.21665503
66GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.21328021
67HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.20640125
68PRDM14_20953172_ChIP-Seq_ESCs_Human1.20496202
69CBX2_27304074_Chip-Seq_ESCs_Mouse1.19740614
70THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.19631115
71TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17990140
72CDX2_22108803_ChIP-Seq_LS180_Human1.17247966
73RUNX2_22187159_ChIP-Seq_PCA_Human1.16760692
74TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11869127
75HOXB7_26014856_ChIP-Seq_BT474_Human1.11509613
76FLI1_21867929_ChIP-Seq_TH2_Mouse1.11300960
77GABP_17652178_ChIP-ChIP_JURKAT_Human1.11293401
78NOTCH1_21737748_ChIP-Seq_TLL_Human1.10116652
79NANOG_18555785_Chip-Seq_ESCs_Mouse1.09979548
80KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.08995350
81PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.08244241
82P53_22387025_ChIP-Seq_ESCs_Mouse1.07910243
83CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.07582795
84RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.06869773
85TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.06175094
86IRF8_22096565_ChIP-ChIP_GC-B_Human1.05839241
87STAT3_18555785_Chip-Seq_ESCs_Mouse1.04052168
88OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03279118
89TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.02065619
90MYC_19829295_ChIP-Seq_ESCs_Human1.00748427
91BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.00475721
92NANOG_20526341_ChIP-Seq_ESCs_Human0.99294275
93PIAS1_25552417_ChIP-Seq_VCAP_Human0.93909204
94RXRA_24833708_ChIP-Seq_LIVER_Mouse0.93523631
95NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.91851365
96NRF2_20460467_ChIP-Seq_MEFs_Mouse0.91851365
97ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.87954050
98NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.86255026
99STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.84679902
100AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.82812007
101SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.79888818
102ERG_21242973_ChIP-ChIP_JURKAT_Human0.79126362
103CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.79015248
104AUTS2_25519132_ChIP-Seq_293T-REX_Human0.78230587
105SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.77975598
106AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.77028220
107SUZ12_27294783_Chip-Seq_NPCs_Mouse0.76330591
108EZH2_27294783_Chip-Seq_NPCs_Mouse0.76217083
109SOX2_27498859_Chip-Seq_STOMACH_Mouse0.75487762
110* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.75226136
111KAP1_22055183_ChIP-Seq_ESCs_Mouse0.73320058
112ESR2_21235772_ChIP-Seq_MCF-7_Human0.72038879
113ZFP57_27257070_Chip-Seq_ESCs_Mouse0.71717640
114MTF2_20144788_ChIP-Seq_MESCs_Mouse0.71431528
115Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.70842981
116SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.70384096
117NFE2_27457419_Chip-Seq_LIVER_Mouse0.69749360
118DROSHA_22980978_ChIP-Seq_HELA_Human0.69525254
119SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.69480068
120RUNX1_27457419_Chip-Seq_LIVER_Mouse0.68938416
121EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.68572686
122MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.67981712
123SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.67696337
124IRF1_19129219_ChIP-ChIP_H3396_Human0.67368379
125OCT4_21477851_ChIP-Seq_ESCs_Mouse0.67169628
126ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.66923556
127CBP_21632823_ChIP-Seq_H3396_Human0.66632401
128BCAT_22108803_ChIP-Seq_LS180_Human0.66376840
129CRX_20693478_ChIP-Seq_RETINA_Mouse0.66166500
130CLOCK_20551151_ChIP-Seq_293T_Human0.66110739
131PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.65629727
132SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.65525289
133EED_16625203_ChIP-ChIP_MESCs_Mouse0.64219098
134EZH2_27294783_Chip-Seq_ESCs_Mouse0.62235843
135STAT1_17558387_ChIP-Seq_HELA_Human0.61893478
136FOXA1_25552417_ChIP-Seq_VCAP_Human0.61477219
137ZNF217_24962896_ChIP-Seq_MCF-7_Human0.60980293
138P300_19829295_ChIP-Seq_ESCs_Human0.60168752
139RAD21_21589869_ChIP-Seq_MESCs_Mouse0.59847412
140SMAD1_18555785_Chip-Seq_ESCs_Mouse0.58908434
141FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.58783205
142SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.58581073
143GATA4_25053715_ChIP-Seq_YYC3_Human0.58439777
144SMAD4_21799915_ChIP-Seq_A2780_Human0.58277217
145EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.58233015
146BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.58123370
147REST_21632747_ChIP-Seq_MESCs_Mouse0.57981161
148SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.57889494
149SMAD4_21741376_ChIP-Seq_EPCs_Human0.57451220
150SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.57398024
151AR_21572438_ChIP-Seq_LNCaP_Human0.56744957
152ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.56556432
153PU1_27457419_Chip-Seq_LIVER_Mouse0.56022029
154MYC_19915707_ChIP-ChIP_AK7_Human0.55992605
155ESET_19884257_ChIP-Seq_ESCs_Mouse0.55186252
156SMAD4_21741376_ChIP-Seq_HESCs_Human0.55142551
157* RNF2_18974828_ChIP-Seq_MESCs_Mouse0.54673564
158* EZH2_18974828_ChIP-Seq_MESCs_Mouse0.54673564
159JARID2_20075857_ChIP-Seq_MESCs_Mouse0.54354622
160STAT3_23295773_ChIP-Seq_U87_Human0.54000911
161GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.53948026
162CTBP1_25329375_ChIP-Seq_LNCAP_Human0.53695046
163UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.53584615
164PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.53426848
165ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.53419619
166IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.53341720
167ESR1_20079471_ChIP-ChIP_T-47D_Human0.53316859
168EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.53269834

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.14503191
2MP0005360_urolithiasis6.99808973
3MP0005085_abnormal_gallbladder_physiolo6.38835961
4MP0005365_abnormal_bile_salt6.07577519
5MP0008875_abnormal_xenobiotic_pharmacok5.00203731
6MP0003252_abnormal_bile_duct3.89791001
7MP0003806_abnormal_nucleotide_metabolis3.86106155
8MP0010329_abnormal_lipoprotein_level3.41759681
9MP0003195_calcinosis3.35719798
10MP0005083_abnormal_biliary_tract3.33689900
11MP0006292_abnormal_olfactory_placode2.92674856
12MP0008877_abnormal_DNA_methylation2.81061745
13MP0009840_abnormal_foam_cell2.80955917
14MP0005332_abnormal_amino_acid2.69906113
15MP0001666_abnormal_nutrient_absorption2.58165842
16MP0003787_abnormal_imprinting2.54118736
17MP0003880_abnormal_central_pattern2.24580858
18MP0004885_abnormal_endolymph2.24474069
19MP0001968_abnormal_touch/_nociception2.21310629
20MP0003868_abnormal_feces_composition2.13379214
21MP0002118_abnormal_lipid_homeostasis2.10701334
22MP0002638_abnormal_pupillary_reflex2.10450091
23MP0004019_abnormal_vitamin_homeostasis2.07215165
24MP0003191_abnormal_cellular_cholesterol1.99743364
25MP0002138_abnormal_hepatobiliary_system1.99157338
26MP0000609_abnormal_liver_physiology1.93864214
27MP0002736_abnormal_nociception_after1.87920348
28MP0002938_white_spotting1.80333256
29MP0001986_abnormal_taste_sensitivity1.79654636
30MP0002102_abnormal_ear_morphology1.78701769
31MP0001764_abnormal_homeostasis1.60210952
32MP0008789_abnormal_olfactory_epithelium1.60027730
33MP0005319_abnormal_enzyme/_coenzyme1.59839658
34MP0000372_irregular_coat_pigmentation1.55444389
35MP0005584_abnormal_enzyme/coenzyme_acti1.54121763
36MP0009697_abnormal_copulation1.53815102
37MP0000427_abnormal_hair_cycle1.47596970
38MP0001485_abnormal_pinna_reflex1.45139215
39MP0005451_abnormal_body_composition1.44583032
40MP0002837_dystrophic_cardiac_calcinosis1.43461099
41MP0005645_abnormal_hypothalamus_physiol1.39695063
42MP0006072_abnormal_retinal_apoptosis1.39330200
43MP0005253_abnormal_eye_physiology1.38029707
44MP0005174_abnormal_tail_pigmentation1.37528073
45MP0010386_abnormal_urinary_bladder1.34765302
46MP0004742_abnormal_vestibular_system1.31461427
47MP0002064_seizures1.30856890
48MP0005647_abnormal_sex_gland1.30760156
49MP0003283_abnormal_digestive_organ1.29799927
50MP0002234_abnormal_pharynx_morphology1.29576804
51MP0000631_abnormal_neuroendocrine_gland1.25822955
52MP0002735_abnormal_chemical_nociception1.25799344
53MP0003011_delayed_dark_adaptation1.22851229
54MP0002572_abnormal_emotion/affect_behav1.21293954
55MP0002557_abnormal_social/conspecific_i1.20683441
56MP0006276_abnormal_autonomic_nervous1.18366886
57MP0003690_abnormal_glial_cell1.18004045
58MP0003136_yellow_coat_color1.16817083
59MP0002876_abnormal_thyroid_physiology1.15587560
60MP0000569_abnormal_digit_pigmentation1.15223696
61MP0003656_abnormal_erythrocyte_physiolo1.13822235
62MP0001970_abnormal_pain_threshold1.12831657
63MP0009643_abnormal_urine_homeostasis1.10481385
64MP0000538_abnormal_urinary_bladder1.10395341
65MP0000604_amyloidosis1.10118351
66MP0002733_abnormal_thermal_nociception1.08855750
67MP0004133_heterotaxia1.08630863
68MP0003646_muscle_fatigue1.06956815
69MP0009764_decreased_sensitivity_to1.06894958
70MP0005499_abnormal_olfactory_system1.06605342
71MP0005394_taste/olfaction_phenotype1.06605342
72MP0005410_abnormal_fertilization1.02965240
73MP0002822_catalepsy1.02748907
74MP0002909_abnormal_adrenal_gland1.01603113
75MP0003186_abnormal_redox_activity1.01429818
76MP0002160_abnormal_reproductive_system1.01354160
77MP0005386_behavior/neurological_phenoty0.99036528
78MP0004924_abnormal_behavior0.99036528
79MP0002734_abnormal_mechanical_nocicepti0.97409212
80MP0005389_reproductive_system_phenotype0.97309546
81MP0003329_amyloid_beta_deposits0.96815392
82MP0000383_abnormal_hair_follicle0.95904367
83MP0002067_abnormal_sensory_capabilities0.95576563
84MP0005636_abnormal_mineral_homeostasis0.95309309
85MP0002254_reproductive_system_inflammat0.94021451
86MP0000598_abnormal_liver_morphology0.91828537
87MP0005084_abnormal_gallbladder_morpholo0.91271504
88MP0003635_abnormal_synaptic_transmissio0.91225306
89MP0000647_abnormal_sebaceous_gland0.90029167
90MP0005535_abnormal_body_temperature0.89216560
91MP0009763_increased_sensitivity_to0.88426590
92MP0001324_abnormal_eye_pigmentation0.87511314
93MP0002653_abnormal_ependyma_morphology0.87387262
94MP0003878_abnormal_ear_physiology0.87230607
95MP0005377_hearing/vestibular/ear_phenot0.87230607
96MP0003121_genomic_imprinting0.87219755
97MP0000639_abnormal_adrenal_gland0.85770315
98MP0005408_hypopigmentation0.85492533
99MP0002095_abnormal_skin_pigmentation0.85475755
100MP0002063_abnormal_learning/memory/cond0.85282592
101MP0001963_abnormal_hearing_physiology0.85132347
102MP0002078_abnormal_glucose_homeostasis0.83465726
103MP0009642_abnormal_blood_homeostasis0.82821838
104MP0009765_abnormal_xenobiotic_induced0.82038324
105MP0000026_abnormal_inner_ear0.80517482
106MP0005195_abnormal_posterior_eye0.80053279
107MP0005670_abnormal_white_adipose0.79141893
108MP0001661_extended_life_span0.78512287
109MP0000613_abnormal_salivary_gland0.75450342
110MP0005220_abnormal_exocrine_pancreas0.73662728
111MP0008469_abnormal_protein_level0.72575698
112MP0004381_abnormal_hair_follicle0.70565396
113MP0004043_abnormal_pH_regulation0.70509420
114MP0005376_homeostasis/metabolism_phenot0.68956722
115MP0005334_abnormal_fat_pad0.67177405
116MP0006036_abnormal_mitochondrial_physio0.64824194
117MP0000920_abnormal_myelination0.63098310
118MP0005646_abnormal_pituitary_gland0.62662963
119MP0008874_decreased_physiological_sensi0.62437771
120MP0004142_abnormal_muscle_tone0.62136338
121MP0002971_abnormal_brown_adipose0.60752854
122MP0008872_abnormal_physiological_respon0.57605722
123MP0005448_abnormal_energy_balance0.56257444
124MP0010368_abnormal_lymphatic_system0.54959984
125MP0003953_abnormal_hormone_level0.53517444
126MP0001756_abnormal_urination0.50217810
127MP0002928_abnormal_bile_duct0.50018824
128MP0004130_abnormal_muscle_cell0.48854374
129MP0000579_abnormal_nail_morphology0.48521408
130MP0005266_abnormal_metabolism0.47995060
131MP0003638_abnormal_response/metabolism_0.47395544
132MP0003632_abnormal_nervous_system0.46477170
133MP0003075_altered_response_to0.45476237
134MP0006035_abnormal_mitochondrial_morpho0.43836859
135MP0000230_abnormal_systemic_arterial0.41276929
136MP0003633_abnormal_nervous_system0.41276168
137MP0004782_abnormal_surfactant_physiolog0.39292395
138MP0005395_other_phenotype0.39259624
139MP0005551_abnormal_eye_electrophysiolog0.38810104
140MP0000566_synostosis0.38723723
141MP0003631_nervous_system_phenotype0.38546762
142MP0003724_increased_susceptibility_to0.37846181
143MP0002229_neurodegeneration0.35886185
144MP0001502_abnormal_circadian_rhythm0.34918316
145MP0001501_abnormal_sleep_pattern0.34619848
146MP0005248_abnormal_Harderian_gland0.34483768
147MP0004147_increased_porphyrin_level0.34438934
148MP0001486_abnormal_startle_reflex0.33985636
149MP0002090_abnormal_vision0.33655855
150MP0002069_abnormal_eating/drinking_beha0.33216469
151MP0001765_abnormal_ion_homeostasis0.32683747
152MP0005166_decreased_susceptibility_to0.32477765
153MP0003718_maternal_effect0.32041296
154MP0002272_abnormal_nervous_system0.31353376
155MP0009046_muscle_twitch0.31344728
156MP0002168_other_aberrant_phenotype0.31080285
157MP0006082_CNS_inflammation0.30967041
158MP0009745_abnormal_behavioral_response0.30621493
159MP0001984_abnormal_olfaction0.30614437
160MP0004883_abnormal_blood_vessel0.30351858
161MP0008873_increased_physiological_sensi0.29947256

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.48751483
2Intrahepatic cholestasis (HP:0001406)7.34349575
3Deep venous thrombosis (HP:0002625)6.93182495
4Prolonged partial thromboplastin time (HP:0003645)6.53957617
5Abnormality of monocarboxylic acid metabolism (HP:0010996)6.40962775
6Xanthomatosis (HP:0000991)5.91282245
7Hypobetalipoproteinemia (HP:0003563)5.86955732
8Hyperlipoproteinemia (HP:0010980)5.42627850
9Complement deficiency (HP:0004431)5.30007039
10Joint hemorrhage (HP:0005261)4.79170646
11Epidermoid cyst (HP:0200040)4.52417325
12Hypolipoproteinemia (HP:0010981)4.39710860
13Abnormality of methionine metabolism (HP:0010901)4.32586341
14Hyperammonemia (HP:0001987)4.23793666
15Hyperglycinemia (HP:0002154)4.21447963
16Abnormality of the common coagulation pathway (HP:0010990)4.21286488
17Fat malabsorption (HP:0002630)4.16336740
18Pancreatic cysts (HP:0001737)4.15001521
19Ketosis (HP:0001946)4.12369836
20Conjugated hyperbilirubinemia (HP:0002908)4.11959509
21Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.10893165
22Abnormality of aspartate family amino acid metabolism (HP:0010899)4.08075544
23Abnormality of sulfur amino acid metabolism (HP:0004339)4.07000783
24Abnormality of midbrain morphology (HP:0002418)3.89738318
25Molar tooth sign on MRI (HP:0002419)3.89738318
26Abnormality of glutamine family amino acid metabolism (HP:0010902)3.89626359
27Hypoalphalipoproteinemia (HP:0003233)3.88616804
28Congenital stationary night blindness (HP:0007642)3.76929722
29Abnormality of complement system (HP:0005339)3.74258294
30Abnormality of serine family amino acid metabolism (HP:0010894)3.71107748
31Abnormality of glycine metabolism (HP:0010895)3.71107748
32Pancreatic fibrosis (HP:0100732)3.67731750
33Hyperglycinuria (HP:0003108)3.61307723
34Abnormality of the intrinsic pathway (HP:0010989)3.60892096
35Hypoglycemic coma (HP:0001325)3.60658783
36Abnormality of pyrimidine metabolism (HP:0004353)3.50216698
37Abnormality of the renal cortex (HP:0011035)3.48684499
38True hermaphroditism (HP:0010459)3.47970533
39Hypercholesterolemia (HP:0003124)3.36452050
40Hyperbilirubinemia (HP:0002904)3.31752671
41Nephronophthisis (HP:0000090)3.28285001
42Steatorrhea (HP:0002570)3.20230313
43Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.10738119
44Delayed CNS myelination (HP:0002188)3.08446540
45Type II lissencephaly (HP:0007260)3.04574073
46Abnormality of fatty-acid metabolism (HP:0004359)3.00228593
47Hypochromic microcytic anemia (HP:0004840)2.98571826
48Ketoacidosis (HP:0001993)2.98209230
49Abnormality of the renal medulla (HP:0100957)2.94610150
50Abnormality of serum amino acid levels (HP:0003112)2.89328090
51Abnormality of nucleobase metabolism (HP:0010932)2.87955766
52Attenuation of retinal blood vessels (HP:0007843)2.85831213
53Hypoglycemic seizures (HP:0002173)2.77020873
54Spontaneous abortion (HP:0005268)2.74992038
55Chronic hepatic failure (HP:0100626)2.72401636
56Vascular calcification (HP:0004934)2.72280385
57Skin nodule (HP:0200036)2.71801437
58Myocardial infarction (HP:0001658)2.69267259
59Abnormality of alanine metabolism (HP:0010916)2.67013739
60Hyperalaninemia (HP:0003348)2.67013739
61Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.67013739
62Hepatocellular carcinoma (HP:0001402)2.66782265
63Systemic lupus erythematosus (HP:0002725)2.66226481
64Medial flaring of the eyebrow (HP:0010747)2.65072462
65Metabolic acidosis (HP:0001942)2.64281261
66Acanthocytosis (HP:0001927)2.60404287
67Gaze-evoked nystagmus (HP:0000640)2.59930081
68Decreased central vision (HP:0007663)2.59444489
69Abnormality of purine metabolism (HP:0004352)2.56825300
70Abnormal gallbladder morphology (HP:0012437)2.54834172
71Abnormal drinking behavior (HP:0030082)2.52503941
72Polydipsia (HP:0001959)2.52503941
73Abnormal rod and cone electroretinograms (HP:0008323)2.48463406
74Cystic liver disease (HP:0006706)2.45934178
75Lethargy (HP:0001254)2.42113101
76Absent rod-and cone-mediated responses on ERG (HP:0007688)2.40833661
77Aplasia/Hypoplasia of the fovea (HP:0008060)2.40377656
78Hypoplasia of the fovea (HP:0007750)2.40377656
79Gout (HP:0001997)2.39030119
80Cholelithiasis (HP:0001081)2.37862185
81Abolished electroretinogram (ERG) (HP:0000550)2.37439548
82Neonatal onset (HP:0003623)2.35051249
83Cardiovascular calcification (HP:0011915)2.34426346
84Mitral stenosis (HP:0001718)2.34125922
85Glomerulonephritis (HP:0000099)2.34118693
86Abnormal gallbladder physiology (HP:0012438)2.33904782
87Cholecystitis (HP:0001082)2.33904782
88Abnormality of vitamin B metabolism (HP:0004340)2.32172632
89Dicarboxylic aciduria (HP:0003215)2.31134811
90Abnormality of dicarboxylic acid metabolism (HP:0010995)2.31134811
91Pendular nystagmus (HP:0012043)2.30758657
92Enlarged kidneys (HP:0000105)2.29793586
93Irritability (HP:0000737)2.29348586
94Amyloidosis (HP:0011034)2.29031857
95Cerebral edema (HP:0002181)2.28014136
96Hyperinsulinemic hypoglycemia (HP:0000825)2.27384523
97Tubular atrophy (HP:0000092)2.26560103
98Hypophosphatemic rickets (HP:0004912)2.23697968
99Hypothermia (HP:0002045)2.23545798
100Polyuria (HP:0000103)2.21086022
101Abnormality of the vitamin B12 metabolism (HP:0004341)2.18354683
102Inability to walk (HP:0002540)2.18330582
103Alkalosis (HP:0001948)2.16887515
104Gingival bleeding (HP:0000225)2.14755341
1053-Methylglutaconic aciduria (HP:0003535)2.14750900
106Decreased circulating renin level (HP:0003351)2.14264750
107Stomach cancer (HP:0012126)2.11303675
108Recurrent gram-negative bacterial infections (HP:0005420)2.11098725
109Status epilepticus (HP:0002133)2.10956268
110Abnormality of urine glucose concentration (HP:0011016)2.09893886
111Glycosuria (HP:0003076)2.09893886
112Cerebellar dysplasia (HP:0007033)2.09441199
113Opisthotonus (HP:0002179)2.09095788
114Rickets (HP:0002748)2.09030079
115Increased CSF lactate (HP:0002490)2.07800675
116Pancreatitis (HP:0001733)2.07461801
117Brushfield spots (HP:0001088)2.07418533
118Type I transferrin isoform profile (HP:0003642)2.06191263
119Methylmalonic aciduria (HP:0012120)2.05998257
120Optic nerve hypoplasia (HP:0000609)2.05656645
121Gait imbalance (HP:0002141)2.04792544
122Abnormality of the fovea (HP:0000493)2.04275321
123Bile duct proliferation (HP:0001408)2.03724967
124Abnormal biliary tract physiology (HP:0012439)2.03724967
125Keratoconus (HP:0000563)2.03586899
126Increased corneal curvature (HP:0100692)2.03586899
127Menorrhagia (HP:0000132)2.03501214
128Lissencephaly (HP:0001339)2.03471954
129Proximal tubulopathy (HP:0000114)2.02457295
130Acute encephalopathy (HP:0006846)2.02239994
131Sensorimotor neuropathy (HP:0007141)2.02121673
132Abnormality of the gallbladder (HP:0005264)2.02020734
133Methylmalonic acidemia (HP:0002912)2.01886244
134Hepatic necrosis (HP:0002605)2.01226349
135Abnormal urine output (HP:0012590)1.99822216
136Metabolic alkalosis (HP:0200114)1.99780527
137Abnormality of macular pigmentation (HP:0008002)1.99668821
138Acute necrotizing encephalopathy (HP:0006965)1.99422500
139Mitochondrial inheritance (HP:0001427)1.99123621
140Hypomagnesemia (HP:0002917)1.99096819
141Late onset (HP:0003584)1.97395308
142Renal cortical cysts (HP:0000803)1.97145350
143Congenital sensorineural hearing impairment (HP:0008527)1.97095008
144Aplasia/Hypoplasia of the tongue (HP:0010295)1.96854592
145Sclerocornea (HP:0000647)1.96702380
146Poikilocytosis (HP:0004447)1.96578732
147Congenital primary aphakia (HP:0007707)1.96269678
148Furrowed tongue (HP:0000221)1.95688464
149Symptomatic seizures (HP:0011145)1.94650077
150Vomiting (HP:0002013)1.94072995
151Decreased electroretinogram (ERG) amplitude (HP:0000654)1.93146793
152Spastic diplegia (HP:0001264)1.92555772
153Broad-based gait (HP:0002136)1.92531121
154Confusion (HP:0001289)1.90150262
155Progressive inability to walk (HP:0002505)1.90034692
156Abnormality of the labia minora (HP:0012880)1.89767899
157Hypoplasia of the pons (HP:0012110)1.87772696
158Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.87455696
159Optic disc pallor (HP:0000543)1.86740838
160Hemiparesis (HP:0001269)1.86430048
161Hypoproteinemia (HP:0003075)1.86189879
162Fair hair (HP:0002286)1.86129081
163Large for gestational age (HP:0001520)1.86070140
164Progressive macrocephaly (HP:0004481)1.85848242
165Abnormality of the pons (HP:0007361)1.85799497
166Abnormality of proline metabolism (HP:0010907)1.85704465
167Hydroxyprolinuria (HP:0003080)1.85704465
168Hepatocellular necrosis (HP:0001404)1.85242970
169Congenital hepatic fibrosis (HP:0002612)1.85094565
170Malnutrition (HP:0004395)1.84819539
171Disproportionate short-trunk short stature (HP:0003521)1.83978178
172Esophageal varix (HP:0002040)1.83754305
173Abnormality of renal excretion (HP:0011036)1.82303012
174Progressive cerebellar ataxia (HP:0002073)1.82215206
175Hemorrhage of the eye (HP:0011885)1.81836330
176Febrile seizures (HP:0002373)1.81714957
177Abnormality of vitamin metabolism (HP:0100508)1.81034280
178Abnormal enzyme/coenzyme activity (HP:0012379)1.80848205
179Nephrogenic diabetes insipidus (HP:0009806)1.78383769
180Abnormal glycosylation (HP:0012345)1.77700986
181Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.77700986
182Abnormal protein N-linked glycosylation (HP:0012347)1.77700986
183Abnormal protein glycosylation (HP:0012346)1.77700986
184Intestinal atresia (HP:0011100)1.76947643
185Generalized aminoaciduria (HP:0002909)1.76232071
186Thrombophlebitis (HP:0004418)1.73404722
187Elevated hepatic transaminases (HP:0002910)1.73092661
188Hyperventilation (HP:0002883)1.72729205
189Hyperglycemia (HP:0003074)1.72214161
190Abnormality of iron homeostasis (HP:0011031)1.70653432
191Abnormality of transition element cation homeostasis (HP:0011030)1.70600169

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.42396993
2INSRR4.18272932
3SIK13.61546542
4MAP4K23.23261181
5FGFR43.22614526
6TAOK33.10785673
7ERBB42.79289866
8MAP2K42.59808226
9ACVR1B2.54858460
10BMPR1B2.34510410
11ERN12.22617927
12MAPK132.18510865
13PINK12.15804517
14NUAK12.10762372
15TRIM282.02990163
16ZAK2.02570314
17PIK3CG1.95882984
18DAPK21.90818953
19MAPK151.69569158
20TLK11.68584786
21FGFR21.64052631
22PKN11.56587452
23MUSK1.53298290
24SGK2231.47781085
25SGK4941.47781085
26TXK1.46254009
27EPHB11.45068525
28OXSR11.37229254
29MAPK111.34695714
30CAMK2G1.32985261
31MST1R1.31906126
32MAP3K141.28439405
33MAP2K71.22520524
34CASK1.22181962
35EPHA41.21269306
36CAMKK21.21155721
37PTK2B1.19477886
38SGK21.18305410
39FRK1.15706888
40STK391.14676838
41SGK31.13755978
42MAP3K71.09724335
43PRKAA21.09627563
44IRAK31.06816438
45STK38L1.06427554
46BCR1.04158656
47MAP3K41.01541999
48MKNK21.01373621
49ADRBK10.97882741
50PRKCZ0.97646150
51PDK20.97154541
52JAK20.96218787
53MARK10.95590697
54LATS10.93809467
55MET0.93639515
56ERBB20.93390610
57JAK10.91341142
58IRAK20.90647849
59PRKCG0.90517552
60PIK3CA0.89581417
61CDK190.88808248
62PTK60.87598802
63MAP3K130.85489692
64WNK30.84973800
65CSNK1G10.83369652
66GRK10.82977759
67TNIK0.82105032
68CSNK1G20.82100259
69ABL20.81668682
70IRAK10.79309399
71TYK20.79290689
72DYRK20.78712955
73NTRK20.77398706
74PLK20.77339754
75PRKCQ0.75137186
76NEK60.74961977
77MAPK70.74588301
78PDPK10.74517123
79BRSK20.74275487
80MAP3K10.73396707
81PRKACG0.73065442
82NTRK30.71998563
83WEE10.71032173
84CAMK1G0.70919163
85CSNK1A1L0.70600354
86MAPK120.70306275
87CSNK1G30.69538843
88NTRK10.69231017
89STK30.67829649
90ITK0.67559066
91CAMK1D0.67261558
92TNK20.67174145
93MAPK40.65899722
94WNK40.64673000
95CAMK2B0.64074966
96IKBKB0.63540184
97CAMK40.63287686
98GSK3A0.63061670
99PRKCH0.62179978
100TEC0.60403673
101AKT30.60331757
102PRKAA10.60030406
103EIF2AK30.59800399
104WNK10.59574981
105FLT30.59572230
106ERBB30.58727951
107PRKCI0.58472453
108CAMK2A0.57795637
109NEK90.57682470
110TIE10.53869188
111CAMKK10.53418947
112MAP2K60.53170944
113VRK10.52044249
114CSNK1A10.51936640
115MINK10.50901956
116KIT0.49827472
117CAMK2D0.48817558
118GRK50.47959758
119MAP2K20.47746919
120PHKG10.47237206
121PHKG20.47237206
122RIPK10.46962859
123EPHA30.46789594
124PDK10.45823453
125RET0.45480344
126PRKCA0.43912071
127PRKACA0.43858369
128IKBKE0.43635419
129PRKG10.43170672
130FER0.42709733
131VRK20.42573750
132TGFBR10.42303280
133IGF1R0.41137984
134PAK30.40748622
135ADRBK20.40006000
136CSNK1D0.39416997
137RPS6KA50.38703771
138SYK0.38596956
139BMPR20.38521499
140MST40.38371385
141CSK0.38312749
142MKNK10.37729645
143STK110.37600561
144MAP2K10.37465422
145PRKCE0.36858204
146PTK20.35690789
147PRKACB0.34121269
148MAPKAPK50.33820659
149RPS6KA30.33609711
150SGK10.32565122
151MAPKAPK30.32519428
152CHUK0.29458341
153PAK60.26721979
154EIF2AK20.26329395

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.43996000
2Nitrogen metabolism_Homo sapiens_hsa009103.73320522
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.21729229
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.14192754
5Arginine biosynthesis_Homo sapiens_hsa002203.02251173
6Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.75938889
7Complement and coagulation cascades_Homo sapiens_hsa046102.66160746
8Tryptophan metabolism_Homo sapiens_hsa003802.64931598
9Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.49371408
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.36315677
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.33677911
12Fatty acid degradation_Homo sapiens_hsa000712.29412239
13Phototransduction_Homo sapiens_hsa047442.26746324
14Butanoate metabolism_Homo sapiens_hsa006502.24354619
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.12954507
16Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.12681166
17Pentose and glucuronate interconversions_Homo sapiens_hsa000402.09802146
18Steroid hormone biosynthesis_Homo sapiens_hsa001402.07948031
19Peroxisome_Homo sapiens_hsa041462.06713274
20Histidine metabolism_Homo sapiens_hsa003402.06670091
21Chemical carcinogenesis_Homo sapiens_hsa052041.85950716
22Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.85516342
23Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.85128237
24Propanoate metabolism_Homo sapiens_hsa006401.84344670
25beta-Alanine metabolism_Homo sapiens_hsa004101.77086172
26PPAR signaling pathway_Homo sapiens_hsa033201.73717196
27Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.72566326
28Retinol metabolism_Homo sapiens_hsa008301.71923732
29Fatty acid metabolism_Homo sapiens_hsa012121.71724919
30Staphylococcus aureus infection_Homo sapiens_hsa051501.66362232
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.66251080
32Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.63309193
33Oxidative phosphorylation_Homo sapiens_hsa001901.62951896
34Steroid biosynthesis_Homo sapiens_hsa001001.56987994
35Bile secretion_Homo sapiens_hsa049761.56070585
36Phenylalanine metabolism_Homo sapiens_hsa003601.54968407
37Fatty acid elongation_Homo sapiens_hsa000621.53581071
38Drug metabolism - other enzymes_Homo sapiens_hsa009831.53149076
39Sulfur metabolism_Homo sapiens_hsa009201.50251378
40Caffeine metabolism_Homo sapiens_hsa002321.47198939
41Tyrosine metabolism_Homo sapiens_hsa003501.45641230
42Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.45035184
43Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.44284821
44Selenocompound metabolism_Homo sapiens_hsa004501.38843282
45ABC transporters_Homo sapiens_hsa020101.34575974
46Protein export_Homo sapiens_hsa030601.33398471
47Mineral absorption_Homo sapiens_hsa049781.29933540
48Maturity onset diabetes of the young_Homo sapiens_hsa049501.29273212
49Pyruvate metabolism_Homo sapiens_hsa006201.24517129
50Starch and sucrose metabolism_Homo sapiens_hsa005001.23110905
51Folate biosynthesis_Homo sapiens_hsa007901.17537318
52Cysteine and methionine metabolism_Homo sapiens_hsa002701.16297331
532-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.15390272
54Parkinsons disease_Homo sapiens_hsa050121.14443174
55Fanconi anemia pathway_Homo sapiens_hsa034601.11646300
56Vitamin B6 metabolism_Homo sapiens_hsa007501.11545196
57Homologous recombination_Homo sapiens_hsa034401.09009714
58Olfactory transduction_Homo sapiens_hsa047401.06832386
59Fat digestion and absorption_Homo sapiens_hsa049751.06754554
60Intestinal immune network for IgA production_Homo sapiens_hsa046721.04782363
61Arginine and proline metabolism_Homo sapiens_hsa003301.01764521
62Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.00503417
63Biosynthesis of amino acids_Homo sapiens_hsa012300.94578470
64Vitamin digestion and absorption_Homo sapiens_hsa049770.94333354
65RNA polymerase_Homo sapiens_hsa030200.93865131
66Basal transcription factors_Homo sapiens_hsa030220.92853199
67Asthma_Homo sapiens_hsa053100.91400260
68Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.90350429
69Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.89217530
70Morphine addiction_Homo sapiens_hsa050320.88213322
71Carbon metabolism_Homo sapiens_hsa012000.84923931
72Cyanoamino acid metabolism_Homo sapiens_hsa004600.84597810
73Serotonergic synapse_Homo sapiens_hsa047260.84453742
74Renin-angiotensin system_Homo sapiens_hsa046140.81818478
75Sulfur relay system_Homo sapiens_hsa041220.76444049
76Lysine degradation_Homo sapiens_hsa003100.75387155
77Glycerolipid metabolism_Homo sapiens_hsa005610.71187209
78Huntingtons disease_Homo sapiens_hsa050160.68674559
79Circadian entrainment_Homo sapiens_hsa047130.68403459
80Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.65916937
81Salivary secretion_Homo sapiens_hsa049700.64989672
82Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.61915480
83Fatty acid biosynthesis_Homo sapiens_hsa000610.60917721
84Alzheimers disease_Homo sapiens_hsa050100.57274135
85RNA degradation_Homo sapiens_hsa030180.56676122
86Glutathione metabolism_Homo sapiens_hsa004800.56376080
87Cardiac muscle contraction_Homo sapiens_hsa042600.55812120
88Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.54878687
89Sphingolipid metabolism_Homo sapiens_hsa006000.50622001
90Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.48443844
91Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.47521870
92Purine metabolism_Homo sapiens_hsa002300.47508815
93Collecting duct acid secretion_Homo sapiens_hsa049660.46535079
94Metabolic pathways_Homo sapiens_hsa011000.46118069
95Type I diabetes mellitus_Homo sapiens_hsa049400.45568678
96One carbon pool by folate_Homo sapiens_hsa006700.44661443
97Calcium signaling pathway_Homo sapiens_hsa040200.42738077
98SNARE interactions in vesicular transport_Homo sapiens_hsa041300.41912892
99alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.41004018
100Prion diseases_Homo sapiens_hsa050200.40304312
101Protein digestion and absorption_Homo sapiens_hsa049740.37968825
102Linoleic acid metabolism_Homo sapiens_hsa005910.37120381
103Dopaminergic synapse_Homo sapiens_hsa047280.35413788
104Circadian rhythm_Homo sapiens_hsa047100.35246201
105Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.34858372
106Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.32189767
107Pentose phosphate pathway_Homo sapiens_hsa000300.30612381
108Glycerophospholipid metabolism_Homo sapiens_hsa005640.27739982
109Ovarian steroidogenesis_Homo sapiens_hsa049130.21802455
110Adipocytokine signaling pathway_Homo sapiens_hsa049200.15821723
111Insulin resistance_Homo sapiens_hsa049310.13330938
112Fructose and mannose metabolism_Homo sapiens_hsa000510.11601943
113Glucagon signaling pathway_Homo sapiens_hsa049220.07789297
114Galactose metabolism_Homo sapiens_hsa000520.07787709
115Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.07568523
116GABAergic synapse_Homo sapiens_hsa047270.06836704
117Ether lipid metabolism_Homo sapiens_hsa005650.04390857
118Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.01988235
119Taste transduction_Homo sapiens_hsa04742-0.1490875
120Cocaine addiction_Homo sapiens_hsa05030-0.1487983
121Aldosterone synthesis and secretion_Homo sapiens_hsa04925-0.1426682
122Glutamatergic synapse_Homo sapiens_hsa04724-0.1411674
123Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1369874
124Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080-0.1321670
125Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.1280120
126African trypanosomiasis_Homo sapiens_hsa05143-0.1266781
127Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1147247
128Insulin secretion_Homo sapiens_hsa04911-0.1130978
129Nicotine addiction_Homo sapiens_hsa05033-0.0888362
130Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563-0.0815447
131Type II diabetes mellitus_Homo sapiens_hsa04930-0.0724091
132AMPK signaling pathway_Homo sapiens_hsa04152-0.0658010
133Thyroid hormone synthesis_Homo sapiens_hsa04918-0.0614386
134Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0563540
135Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.0299688
136Regulation of autophagy_Homo sapiens_hsa04140-0.0075072

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »