FAF2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is highly expressed in peripheral blood of patients with atopic dermatitis (AD), compared to normal individuals. It may play a role in regulating the resistance to apoptosis that is observed in T cells and eosinophils of AD patients. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.47180462
2COPI coating of Golgi vesicle (GO:0048205)5.04665489
3Golgi transport vesicle coating (GO:0048200)5.04665489
4nuclear pore organization (GO:0006999)4.77175850
5negative regulation of fibrinolysis (GO:0051918)4.36510520
6pore complex assembly (GO:0046931)4.15016119
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.12756226
8L-phenylalanine catabolic process (GO:0006559)4.12756226
9ribosome assembly (GO:0042255)4.02544182
10serine family amino acid catabolic process (GO:0009071)3.98597087
11L-phenylalanine metabolic process (GO:0006558)3.92193979
12erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.92193979
13glycine metabolic process (GO:0006544)3.87487240
14maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.87192154
15regulation of spindle organization (GO:0090224)3.83573084
16alpha-linolenic acid metabolic process (GO:0036109)3.77510072
17mitotic chromosome condensation (GO:0007076)3.74728895
18mitotic metaphase plate congression (GO:0007080)3.63348987
19hemidesmosome assembly (GO:0031581)3.60387724
20protein carboxylation (GO:0018214)3.58737019
21peptidyl-glutamic acid carboxylation (GO:0017187)3.58737019
22mitotic sister chromatid cohesion (GO:0007064)3.56960399
23regulation of fibrinolysis (GO:0051917)3.56157313
24DNA unwinding involved in DNA replication (GO:0006268)3.54279824
25regulation of mitotic spindle organization (GO:0060236)3.52038054
26COPII vesicle coating (GO:0048208)3.51136504
27mitotic sister chromatid segregation (GO:0000070)3.49461121
28establishment of integrated proviral latency (GO:0075713)3.47676641
29protein retention in ER lumen (GO:0006621)3.47448236
30regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.42964892
31collagen fibril organization (GO:0030199)3.34642085
32sister chromatid segregation (GO:0000819)3.32948429
33protein localization to chromosome, centromeric region (GO:0071459)3.32518501
34skin morphogenesis (GO:0043589)3.31747111
35aromatic amino acid family catabolic process (GO:0009074)3.28072315
36regulation of transforming growth factor beta2 production (GO:0032909)3.26173483
37activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.24586431
38metaphase plate congression (GO:0051310)3.24119190
39regulation of hippo signaling (GO:0035330)3.22938144
40vesicle coating (GO:0006901)3.20370718
41G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.18543981
42ER overload response (GO:0006983)3.18382580
43cellular glucuronidation (GO:0052695)3.17580960
44regulation of translational termination (GO:0006449)3.16673570
45cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.15286752
46sulfur amino acid catabolic process (GO:0000098)3.15243545
47regulation of RNA export from nucleus (GO:0046831)3.10317954
48regulation of plasminogen activation (GO:0010755)3.06629985
49positive regulation of nuclease activity (GO:0032075)3.06544923
50protein localization to kinetochore (GO:0034501)3.04450434
51amino-acid betaine metabolic process (GO:0006577)3.03852633
52mitotic nuclear envelope disassembly (GO:0007077)3.02560423
53tRNA aminoacylation for protein translation (GO:0006418)3.01116360
54negative regulation of keratinocyte proliferation (GO:0010839)2.99905720
55serine family amino acid metabolic process (GO:0009069)2.99871104
56endoplasmic reticulum unfolded protein response (GO:0030968)2.98063884
57glyoxylate metabolic process (GO:0046487)2.96076469
58cell adhesion mediated by integrin (GO:0033627)2.95535065
59UDP-N-acetylglucosamine metabolic process (GO:0006047)2.93889424
60amino acid activation (GO:0043038)2.93332980
61tRNA aminoacylation (GO:0043039)2.93332980
62regulation of sister chromatid cohesion (GO:0007063)2.93163977
63triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.92287693
64regulation of translational fidelity (GO:0006450)2.92135856
65desmosome organization (GO:0002934)2.91919855
66nuclear envelope disassembly (GO:0051081)2.91438343
67membrane disassembly (GO:0030397)2.91438343
68protein localization to microtubule (GO:0035372)2.91382356
69cellular response to unfolded protein (GO:0034620)2.91192336
70positive regulation of extracellular matrix organization (GO:1903055)2.91188781
71spliceosomal tri-snRNP complex assembly (GO:0000244)2.87344708
72high-density lipoprotein particle remodeling (GO:0034375)2.86345758
73DNA duplex unwinding (GO:0032508)2.85910872
74positive regulation of DNA-dependent DNA replication (GO:2000105)2.85273652
75regulation of cholesterol biosynthetic process (GO:0045540)2.84233516
76regulation of protein activation cascade (GO:2000257)2.83059691
77urea metabolic process (GO:0019627)2.82364533
78urea cycle (GO:0000050)2.82364533
79regulation of nuclease activity (GO:0032069)2.81920699
80endodermal cell differentiation (GO:0035987)2.81693101
81establishment of chromosome localization (GO:0051303)2.80923813
82regulation of cholesterol homeostasis (GO:2000188)2.79133679
83establishment of viral latency (GO:0019043)2.78331201
84ER-nucleus signaling pathway (GO:0006984)2.78140506
85serine family amino acid biosynthetic process (GO:0009070)2.77756002
86aldehyde catabolic process (GO:0046185)2.77149399
87polarized epithelial cell differentiation (GO:0030859)2.77117638
88cellular protein complex localization (GO:0034629)2.76839270
89glucuronate metabolic process (GO:0019585)2.76820953
90uronic acid metabolic process (GO:0006063)2.76820953
91DNA geometric change (GO:0032392)2.76257837
92mitotic cytokinesis (GO:0000281)2.76081440
93reverse cholesterol transport (GO:0043691)2.75359488
94midgut development (GO:0007494)2.75053956
95homocysteine metabolic process (GO:0050667)2.74762366
96formation of translation preinitiation complex (GO:0001731)2.73585316
974-hydroxyproline metabolic process (GO:0019471)2.72709710
98nucleotide-sugar biosynthetic process (GO:0009226)2.71990478
99tyrosine metabolic process (GO:0006570)2.71702550
100protein complex localization (GO:0031503)2.71588058
101negative regulation of sterol transport (GO:0032372)2.70957697
102negative regulation of cholesterol transport (GO:0032375)2.70957697
103retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.70454217
104regulation of nucleobase-containing compound transport (GO:0032239)2.69720681
105L-serine metabolic process (GO:0006563)2.68885928
106cellular response to topologically incorrect protein (GO:0035967)2.68584433
107lipoprotein metabolic process (GO:0042157)2.67015066
108hippo signaling (GO:0035329)2.66829828
109chondrocyte development (GO:0002063)2.66525059
110nucleobase-containing small molecule interconversion (GO:0015949)2.66519541
111bile acid biosynthetic process (GO:0006699)2.64906871
112regulation of complement activation (GO:0030449)2.64832632
113positive regulation of fatty acid beta-oxidation (GO:0032000)2.63162764
114acylglycerol homeostasis (GO:0055090)2.61434844
115triglyceride homeostasis (GO:0070328)2.61434844
116chondrocyte proliferation (GO:0035988)2.61249546
117pre-miRNA processing (GO:0031054)2.60422380
118regulation of extracellular matrix disassembly (GO:0010715)2.60358396
119epithelial cell differentiation involved in prostate gland development (GO:0060742)2.59592537
120proline biosynthetic process (GO:0006561)2.58005590
121endocardial cushion development (GO:0003197)2.57571791
122epoxygenase P450 pathway (GO:0019373)2.57362343
123regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.56918827
124peptidyl-arginine omega-N-methylation (GO:0035247)2.56530961
125positive regulation of chromosome segregation (GO:0051984)2.55832132
126non-recombinational repair (GO:0000726)2.55795398
127double-strand break repair via nonhomologous end joining (GO:0006303)2.55795398
128regulation of translational elongation (GO:0006448)2.55036198
129ethanol oxidation (GO:0006069)2.54949326
130positive regulation of endothelial cell apoptotic process (GO:2000353)2.54202702
131regulation of fatty acid beta-oxidation (GO:0031998)2.52914325
132pyrimidine-containing compound transmembrane transport (GO:0072531)2.52901207
133fibrinolysis (GO:0042730)2.51638399
134DNA strand elongation (GO:0022616)2.51584447
135intestinal cholesterol absorption (GO:0030299)2.51551371
136kynurenine metabolic process (GO:0070189)2.50889991
137paraxial mesoderm development (GO:0048339)2.50611363
138folic acid-containing compound biosynthetic process (GO:0009396)2.49643399
139male genitalia development (GO:0030539)2.49420028
140protein hydroxylation (GO:0018126)2.48202679
141protein maturation by protein folding (GO:0022417)2.48087145
142nuclear envelope organization (GO:0006998)2.47739969
143DNA strand elongation involved in DNA replication (GO:0006271)2.47406896
144negative regulation of DNA repair (GO:0045738)2.46800989
145regulation of gastrulation (GO:0010470)2.46607952
146regulation of chromosome segregation (GO:0051983)2.45396597
147bile acid metabolic process (GO:0008206)2.44861554
148spindle checkpoint (GO:0031577)2.43911005
149embryonic retina morphogenesis in camera-type eye (GO:0060059)2.43705472
150response to endoplasmic reticulum stress (GO:0034976)2.43338515
151regulation of extracellular matrix organization (GO:1903053)2.42280335
152tryptophan catabolic process (GO:0006569)2.41925000
153indole-containing compound catabolic process (GO:0042436)2.41925000
154indolalkylamine catabolic process (GO:0046218)2.41925000
155positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.41501555
156positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.41501555
157positive regulation of mitotic sister chromatid separation (GO:1901970)2.41501555
158peptidyl-asparagine modification (GO:0018196)2.41006492
159imidazole-containing compound metabolic process (GO:0052803)2.40403403
160protein N-linked glycosylation via asparagine (GO:0018279)2.39235936
161endothelial cell morphogenesis (GO:0001886)2.37567098
162regulation of centriole replication (GO:0046599)2.37083528
163mitotic spindle organization (GO:0007052)2.36830392
164cholesterol efflux (GO:0033344)2.36809466
165one-carbon metabolic process (GO:0006730)2.36445729
166histone-serine phosphorylation (GO:0035404)2.35990901
167cytoskeleton-dependent cytokinesis (GO:0061640)2.35893260
168regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.35774176
169complement activation, alternative pathway (GO:0006957)2.35055527
170mammary gland epithelial cell proliferation (GO:0033598)2.34576393
171protein export from nucleus (GO:0006611)2.34003414
172anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.33416645
173DNA conformation change (GO:0071103)2.33091470
174cellular copper ion homeostasis (GO:0006878)2.30885848
175heterochromatin organization (GO:0070828)2.29380635
176spindle assembly involved in mitosis (GO:0090307)2.27960660
177mitotic spindle checkpoint (GO:0071174)2.25017561
178regulation of DNA endoreduplication (GO:0032875)2.23930995
179protein N-linked glycosylation (GO:0006487)2.23875295
180pteridine-containing compound biosynthetic process (GO:0042559)2.22121403
181regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.20973509
182regulation of mitotic metaphase/anaphase transition (GO:0030071)2.20973509

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.85858306
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.39092696
3TP63_17297297_ChIP-ChIP_HaCaT_Human4.58596511
4RXR_22158963_ChIP-Seq_LIVER_Mouse4.09545224
5PPARA_22158963_ChIP-Seq_LIVER_Mouse3.74080339
6MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.60616860
7EGR1_19374776_ChIP-ChIP_THP-1_Human3.56842777
8TRIM28_21343339_ChIP-Seq_HEK293_Human3.45749777
9LXR_22158963_ChIP-Seq_LIVER_Mouse3.29877007
10MYC_18555785_ChIP-Seq_MESCs_Mouse3.17424646
11RARG_19884340_ChIP-ChIP_MEFs_Mouse2.98742945
12CLOCK_20551151_ChIP-Seq_293T_Human2.92103764
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.91525392
14KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.91267832
15E2F4_17652178_ChIP-ChIP_JURKAT_Human2.72591096
16FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.69961353
17EGR1_23403033_ChIP-Seq_LIVER_Mouse2.57526518
18EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.53595746
19CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.46903610
20NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.46546952
21HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.34046378
22CREB1_15753290_ChIP-ChIP_HEK293T_Human2.32479243
23MYC_19030024_ChIP-ChIP_MESCs_Mouse2.29677485
24NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.24258637
25CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.22582837
26ZNF263_19887448_ChIP-Seq_K562_Human2.21242546
27RBPJ_22232070_ChIP-Seq_NCS_Mouse2.12368016
28DCP1A_22483619_ChIP-Seq_HELA_Human2.10911337
29GABP_17652178_ChIP-ChIP_JURKAT_Human2.10763202
30MYC_19079543_ChIP-ChIP_MESCs_Mouse2.09021661
31ELK1_19687146_ChIP-ChIP_HELA_Human2.03664508
32FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.99254576
33PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.97324623
34NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.95142183
35* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.92969466
36STAT6_21828071_ChIP-Seq_BEAS2B_Human1.92929518
37JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.91561687
38TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.91144313
39AR_21909140_ChIP-Seq_LNCAP_Human1.90221014
40MYC_18358816_ChIP-ChIP_MESCs_Mouse1.87154347
41E2F1_21310950_ChIP-Seq_MCF-7_Human1.86595115
42PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.84741453
43XRN2_22483619_ChIP-Seq_HELA_Human1.80046679
44ESR1_21235772_ChIP-Seq_MCF-7_Human1.78533193
45ETS1_20019798_ChIP-Seq_JURKAT_Human1.73890928
46E2F1_18555785_ChIP-Seq_MESCs_Mouse1.72879016
47CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.67067856
48RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.65282970
49TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.63599098
50HIF1A_21447827_ChIP-Seq_MCF-7_Human1.59418570
51KDM5A_27292631_Chip-Seq_BREAST_Human1.58967670
52* BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.58071406
53* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.57995403
54* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.56658288
55FOXO3_23340844_ChIP-Seq_DLD1_Human1.56585223
56SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.56347268
57THAP11_20581084_ChIP-Seq_MESCs_Mouse1.55400242
58FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.55131482
59* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.54993748
60HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.54954692
61PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.53356345
62POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.50670925
63EST1_17652178_ChIP-ChIP_JURKAT_Human1.50090746
64* GABP_19822575_ChIP-Seq_HepG2_Human1.48813611
65TTF2_22483619_ChIP-Seq_HELA_Human1.48418037
66ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.47700148
67SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.47656223
68* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.47605302
69STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.47175074
70BRD4_25478319_ChIP-Seq_HGPS_Human1.45547227
71SALL4_18804426_ChIP-ChIP_XEN_Mouse1.45031840
72EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.44709461
73SALL1_21062744_ChIP-ChIP_HESCs_Human1.44121765
74TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.41611867
75SOX2_27498859_Chip-Seq_STOMACH_Mouse1.41510768
76NANOG_18555785_ChIP-Seq_MESCs_Mouse1.41209229
77MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.40193937
78KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.39768259
79NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.39171810
80ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.38893662
81PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.35034453
82NELFA_20434984_ChIP-Seq_ESCs_Mouse1.33618157
83TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.33546224
84CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.31862076
85* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.31539282
86CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.29589706
87SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.26321396
88SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.26321396
89TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.25270549
90CHD1_26751641_Chip-Seq_LNCaP_Human1.23235671
91FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.20221057
92GATA6_25053715_ChIP-Seq_YYC3_Human1.19203091
93FOXA2_19822575_ChIP-Seq_HepG2_Human1.18973953
94GATA4_25053715_ChIP-Seq_YYC3_Human1.18849545
95ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.17725315
96ATF3_27146783_Chip-Seq_COLON_Human1.16351476
97HOXB4_20404135_ChIP-ChIP_EML_Mouse1.15895386
98FOXM1_23109430_ChIP-Seq_U2OS_Human1.15807570
99CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.15291697
100MYCN_18555785_ChIP-Seq_MESCs_Mouse1.14892914
101SOX17_20123909_ChIP-Seq_XEN_Mouse1.14859570
102ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.13582049
103ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.09996712
104UBF1/2_26484160_Chip-Seq_HMECs_Human1.08440604
105ERG_20887958_ChIP-Seq_HPC-7_Mouse1.08073454
106ESR2_21235772_ChIP-Seq_MCF-7_Human1.07924465
107P300_27058665_Chip-Seq_ZR-75-30cells_Human1.06556525
108TCF3_18692474_ChIP-Seq_MEFs_Mouse1.06346616
109ESR1_15608294_ChIP-ChIP_MCF-7_Human1.06201781
110E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.05092477
111STAT3_1855785_ChIP-Seq_MESCs_Mouse1.05054291
112WT1_19549856_ChIP-ChIP_CCG9911_Human1.04310192
113CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.03155846
114SOX2_18555785_ChIP-Seq_MESCs_Mouse1.01683780
115HNF4A_19822575_ChIP-Seq_HepG2_Human1.01347748
116ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.01203547
117NRF2_20460467_ChIP-Seq_MEFs_Mouse1.00474060
118NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.00474060
119FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.99757651
120NANOG_21062744_ChIP-ChIP_HESCs_Human0.99201206
121HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.98598776
122POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.98091686
123TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.98014518
124KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.97877803
125TFEB_21752829_ChIP-Seq_HELA_Human0.97722753
126ZFX_18555785_ChIP-Seq_MESCs_Mouse0.97632771
127ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.97526484
128GATA4_21415370_ChIP-Seq_HL-1_Mouse0.97357141
129FOXP3_21729870_ChIP-Seq_TREG_Human0.97115512
130SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.96986538
131ELK1_22589737_ChIP-Seq_MCF10A_Human0.96155340
132FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.96134119
133SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.95917784
134SOX9_24532713_ChIP-Seq_HFSC_Mouse0.95882692
135NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.95525128
136SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.95115712
137PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.94220295
138PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.94145291
139RACK7_27058665_Chip-Seq_MCF-7_Human0.93533925
140CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.93520167
141TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.93475038
142ELF5_23300383_ChIP-Seq_T47D_Human0.92747543
143HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.92686563
144GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.92329727
145TCF3_18692474_ChIP-Seq_MESCs_Mouse0.90757181
146SOX2_20726797_ChIP-Seq_SW620_Human0.89550100
147RARB_24833708_ChIP-Seq_LIVER_Mouse0.89248791
148* PADI4_21655091_ChIP-ChIP_MCF-7_Human0.86094227
149KLF4_18555785_ChIP-Seq_MESCs_Mouse0.85595244
150CJUN_26792858_Chip-Seq_BT549_Human0.85574616
151TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.84871723
152TP53_22127205_ChIP-Seq_IMR90_Human0.82942457
153KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.82037492
154GATA1_22025678_ChIP-Seq_K562_Human0.81999353
155JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.81985957
156PPAR_26484153_Chip-Seq_NCI-H1993_Human0.80852886

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.15689122
2MP0002139_abnormal_hepatobiliary_system4.05230561
3MP0008057_abnormal_DNA_replication3.54269315
4MP0003705_abnormal_hypodermis_morpholog3.45002196
5MP0005360_urolithiasis3.23248899
6MP0003693_abnormal_embryo_hatching3.06040949
7MP0004957_abnormal_blastocyst_morpholog2.80502646
8MP0003111_abnormal_nucleus_morphology2.67290955
9MP0009840_abnormal_foam_cell2.61912467
10MP0005085_abnormal_gallbladder_physiolo2.49782502
11MP0010094_abnormal_chromosome_stability2.45045863
12MP0005365_abnormal_bile_salt2.44944247
13MP0003077_abnormal_cell_cycle2.40711805
14MP0004272_abnormal_basement_membrane2.40369268
15MP0005503_abnormal_tendon_morphology2.35141147
16MP0006054_spinal_hemorrhage2.34044717
17MP0010352_gastrointestinal_tract_polyps2.23741487
18MP0005275_abnormal_skin_tensile2.15537878
19MP0008932_abnormal_embryonic_tissue2.09500253
20MP0008007_abnormal_cellular_replicative2.00189517
21MP0009053_abnormal_anal_canal1.97699746
22MP0004233_abnormal_muscle_weight1.94507641
23MP0009384_cardiac_valve_regurgitation1.89310700
24MP0005076_abnormal_cell_differentiation1.87488852
25MP0008058_abnormal_DNA_repair1.80766627
26MP0010030_abnormal_orbit_morphology1.77851752
27MP0000579_abnormal_nail_morphology1.70986046
28MP0000350_abnormal_cell_proliferation1.66562642
29MP0005023_abnormal_wound_healing1.66033912
30MP0004134_abnormal_chest_morphology1.65686042
31MP0005623_abnormal_meninges_morphology1.64404224
32MP0000537_abnormal_urethra_morphology1.64129175
33MP0003566_abnormal_cell_adhesion1.63132915
34MP0003890_abnormal_embryonic-extraembry1.62939643
35MP0009697_abnormal_copulation1.62249184
36MP0000428_abnormal_craniofacial_morphol1.57137375
37MP0002060_abnormal_skin_morphology1.55862765
38MP0001666_abnormal_nutrient_absorption1.53729140
39MP0003252_abnormal_bile_duct1.51362259
40MP0003279_aneurysm1.48562541
41MP0010329_abnormal_lipoprotein_level1.46531330
42MP0001697_abnormal_embryo_size1.46304855
43MP0003950_abnormal_plasma_membrane1.46196660
44MP0002084_abnormal_developmental_patter1.45670071
45MP0002796_impaired_skin_barrier1.39776087
46MP0005501_abnormal_skin_physiology1.38228152
47MP0003315_abnormal_perineum_morphology1.37101823
48MP0001849_ear_inflammation1.35677880
49MP0005508_abnormal_skeleton_morphology1.33878314
50MP0002085_abnormal_embryonic_tissue1.33426907
51MP0002877_abnormal_melanocyte_morpholog1.31597111
52MP0002080_prenatal_lethality1.31307214
53MP0001958_emphysema1.30632638
54MP0005083_abnormal_biliary_tract1.29647682
55MP0002896_abnormal_bone_mineralization1.29056894
56MP0003115_abnormal_respiratory_system1.28992671
57MP0005257_abnormal_intraocular_pressure1.28574255
58MP0001299_abnormal_eye_distance/1.26025678
59MP0003385_abnormal_body_wall1.23980858
60MP0003806_abnormal_nucleotide_metabolis1.21815554
61MP0005220_abnormal_exocrine_pancreas1.21300664
62MP0001216_abnormal_epidermal_layer1.19896998
63MP0001293_anophthalmia1.18216390
64MP0009780_abnormal_chondrocyte_physiolo1.18145494
65MP0002111_abnormal_tail_morphology1.17607977
66MP0003942_abnormal_urinary_system1.17575900
67MP0004197_abnormal_fetal_growth/weight/1.16120012
68MP0005248_abnormal_Harderian_gland1.14577337
69MP0000462_abnormal_digestive_system1.14158973
70MP0002282_abnormal_trachea_morphology1.14147437
71MP0005332_abnormal_amino_acid1.13166195
72MP0008875_abnormal_xenobiotic_pharmacok1.12702498
73MP0000647_abnormal_sebaceous_gland1.12227951
74MP0003091_abnormal_cell_migration1.11718011
75MP0010307_abnormal_tumor_latency1.11295841
76MP0000163_abnormal_cartilage_morphology1.11147953
77MP0001243_abnormal_dermal_layer1.10186865
78MP0003453_abnormal_keratinocyte_physiol1.09728450
79MP0003195_calcinosis1.08431580
80MP0000627_abnormal_mammary_gland1.08190225
81MP0005408_hypopigmentation1.06261007
82MP0010368_abnormal_lymphatic_system1.05949346
83MP0005197_abnormal_uvea_morphology1.05192845
84MP0005621_abnormal_cell_physiology1.04500380
85MP0002697_abnormal_eye_size1.03482655
86MP0004264_abnormal_extraembryonic_tissu1.03178118
87MP0000358_abnormal_cell_content/1.02107952
88MP0002254_reproductive_system_inflammat1.02100458
89MP0010234_abnormal_vibrissa_follicle1.01697677
90MP0009250_abnormal_appendicular_skeleto1.01145095
91MP0003937_abnormal_limbs/digits/tail_de1.01029862
92MP0002115_abnormal_skeleton_extremities1.00593493
93MP0002098_abnormal_vibrissa_morphology0.99771062
94MP0001348_abnormal_lacrimal_gland0.99255823
95MP0002233_abnormal_nose_morphology0.98906587
96MP0000609_abnormal_liver_physiology0.98893583
97MP0002092_abnormal_eye_morphology0.98468132
98MP0003119_abnormal_digestive_system0.97407979
99MP0009672_abnormal_birth_weight0.96574268
100MP0000377_abnormal_hair_follicle0.96459257
101MP0008789_abnormal_olfactory_epithelium0.95278767
102MP0005384_cellular_phenotype0.94103010
103MP0003718_maternal_effect0.93950123
104MP0003755_abnormal_palate_morphology0.93433299
105MP0003123_paternal_imprinting0.92806562
106MP0002653_abnormal_ependyma_morphology0.92553717
107MP0001915_intracranial_hemorrhage0.91437022
108MP0003868_abnormal_feces_composition0.91190835
109MP0000003_abnormal_adipose_tissue0.90479822
110MP0000534_abnormal_ureter_morphology0.89845795
111MP0003941_abnormal_skin_development0.89141972
112MP0004782_abnormal_surfactant_physiolog0.89000327
113MP0001286_abnormal_eye_development0.88227814
114MP0000383_abnormal_hair_follicle0.87432665
115MP0002177_abnormal_outer_ear0.85503817
116MP0001727_abnormal_embryo_implantation0.85103742
117MP0000467_abnormal_esophagus_morphology0.85049648
118MP0002113_abnormal_skeleton_development0.84802014
119MP0000432_abnormal_head_morphology0.84697749
120MP0000013_abnormal_adipose_tissue0.84404818
121MP0003283_abnormal_digestive_organ0.84304800
122MP0003935_abnormal_craniofacial_develop0.84204618
123MP0009703_decreased_birth_body0.83494122
124MP0002933_joint_inflammation0.82931563
125MP0000733_abnormal_muscle_development0.81357606
126MP0003943_abnormal_hepatobiliary_system0.80999194
127MP0001270_distended_abdomen0.79901409
128MP0003984_embryonic_growth_retardation0.79453968
129MP0000762_abnormal_tongue_morphology0.79331571
130MP0001881_abnormal_mammary_gland0.79021434
131MP0002088_abnormal_embryonic_growth/wei0.78522467
132MP0001730_embryonic_growth_arrest0.78043553
133MP0001346_abnormal_lacrimal_gland0.77794427
134MP0005451_abnormal_body_composition0.77409452
135MP0010678_abnormal_skin_adnexa0.76982115
136MP0001177_atelectasis0.76669353
137MP0010771_integument_phenotype0.76636240
138MP0008260_abnormal_autophagy0.76607743
139MP0002168_other_aberrant_phenotype0.76265030
140MP0001672_abnormal_embryogenesis/_devel0.75562936
141MP0005380_embryogenesis_phenotype0.75562936
142MP0001661_extended_life_span0.75177032
143MP0002109_abnormal_limb_morphology0.74749542
144MP0002086_abnormal_extraembryonic_tissu0.73872457

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)4.75457822
2Protrusio acetabuli (HP:0003179)4.12527679
3Renal duplication (HP:0000075)3.59421018
4Bladder diverticulum (HP:0000015)3.55247472
5Hyperacusis (HP:0010780)3.38102910
6Abnormal tarsal ossification (HP:0008369)3.34240274
7Degeneration of anterior horn cells (HP:0002398)3.32544891
8Abnormality of the anterior horn cell (HP:0006802)3.32544891
9Renovascular hypertension (HP:0100817)3.30031430
10Abnormal foot bone ossification (HP:0010675)3.16405034
11Deep venous thrombosis (HP:0002625)3.16335660
12Intrahepatic cholestasis (HP:0001406)3.13765685
13Hypobetalipoproteinemia (HP:0003563)3.12745044
14Bowel diverticulosis (HP:0005222)3.08971802
15Overriding aorta (HP:0002623)3.07272054
16Upper motor neuron abnormality (HP:0002127)3.06099078
17Epiphyseal dysplasia (HP:0002656)3.02542737
18Abnormality of monocarboxylic acid metabolism (HP:0010996)2.94570031
19Abnormality of the lower motor neuron (HP:0002366)2.87222156
20Cervical subluxation (HP:0003308)2.86462686
21Overlapping toe (HP:0001845)2.84252390
22Cupped ribs (HP:0000887)2.82369233
23Vitreoretinal degeneration (HP:0000655)2.81720004
24Flat acetabular roof (HP:0003180)2.81018108
25Elfin facies (HP:0004428)2.79994887
26Xanthomatosis (HP:0000991)2.76148450
27Flat cornea (HP:0007720)2.75326054
28Atrophic scars (HP:0001075)2.72726290
29Abnormality of aromatic amino acid family metabolism (HP:0004338)2.68150988
30Selective tooth agenesis (HP:0001592)2.64351739
31Septate vagina (HP:0001153)2.59992484
32Increased nuchal translucency (HP:0010880)2.58949923
33Arterial tortuosity (HP:0005116)2.57370726
34Toxemia of pregnancy (HP:0100603)2.55928672
35Deviation of the thumb (HP:0009603)2.54886453
36Small epiphyses (HP:0010585)2.49346847
37Termporal pattern (HP:0011008)2.47832159
38Insidious onset (HP:0003587)2.47832159
39Cortical dysplasia (HP:0002539)2.47665312
40Microglossia (HP:0000171)2.45851884
41Hallux valgus (HP:0001822)2.45662070
42Asymmetry of the thorax (HP:0001555)2.43497257
43Deviation of the hallux (HP:0010051)2.42254141
44Polygenic inheritance (HP:0010982)2.42224091
45Shallow orbits (HP:0000586)2.39506069
46Abnormality of carpal bone ossification (HP:0006257)2.36972056
47Abnormality of the diencephalon (HP:0010662)2.32978257
48Abnormality of the umbilical cord (HP:0010881)2.32689170
49Trismus (HP:0000211)2.32611667
50Proximal placement of thumb (HP:0009623)2.32597250
51Blue sclerae (HP:0000592)2.32083670
52Insomnia (HP:0100785)2.31801419
53Vascular tortuosity (HP:0004948)2.31785538
54Neonatal short-limb short stature (HP:0008921)2.30905418
55Entropion (HP:0000621)2.29109373
56Abnormal umbilical cord blood vessels (HP:0011403)2.26756426
57Single umbilical artery (HP:0001195)2.26756426
58Abnormality of the fetal cardiovascular system (HP:0010948)2.26756426
59Curly hair (HP:0002212)2.26738252
60Hypolipoproteinemia (HP:0010981)2.25991142
61Soft skin (HP:0000977)2.25957664
62Short nail (HP:0001799)2.24742175
63Irregular epiphyses (HP:0010582)2.23662042
64Biconcave vertebral bodies (HP:0004586)2.21821649
65Abnormal ossification of hand bones (HP:0005921)2.21229113
66Mitral stenosis (HP:0001718)2.19666652
67Abnormality of glycolysis (HP:0004366)2.17800439
68Flattened epiphyses (HP:0003071)2.16827746
69Vertebral compression fractures (HP:0002953)2.16691001
70Coronal craniosynostosis (HP:0004440)2.15317328
71Chromsome breakage (HP:0040012)2.14958898
72Metaphyseal cupping (HP:0003021)2.14795997
73Osteoarthritis (HP:0002758)2.14430839
74Abnormal hand bone ossification (HP:0010660)2.10860851
75Hypoplastic ischia (HP:0003175)2.10567955
76Aortic dissection (HP:0002647)2.10358084
77Unilateral renal agenesis (HP:0000122)2.10194367
78Natal tooth (HP:0000695)2.10033967
79Protuberant abdomen (HP:0001538)2.09499366
80Ectopia lentis (HP:0001083)2.08162736
81Chromosomal breakage induced by crosslinking agents (HP:0003221)2.07886632
82Multiple enchondromatosis (HP:0005701)2.07539911
83Peritonitis (HP:0002586)2.06697732
84Ulnar bowing (HP:0003031)2.05433077
85Abnormalities of placenta or umbilical cord (HP:0001194)2.04321357
86Hyperglycinemia (HP:0002154)2.03918987
87Ankle contracture (HP:0006466)2.02628593
88Onycholysis (HP:0001806)1.99938572
89Hand muscle atrophy (HP:0009130)1.99370841
90Abnormality of the distal phalanges of the toes (HP:0010182)1.99328352
91Abnormality of oral frenula (HP:0000190)1.99149639
92Deep philtrum (HP:0002002)1.98879190
93Back pain (HP:0003418)1.97311208
94Cerebral aneurysm (HP:0004944)1.97006745
95Advanced eruption of teeth (HP:0006288)1.95496069
96Glossoptosis (HP:0000162)1.95329366
97Osteolytic defects of the phalanges of the hand (HP:0009771)1.94354464
98Osteolytic defects of the hand bones (HP:0009699)1.94354464
99Upper limb amyotrophy (HP:0009129)1.93448745
100Distal upper limb amyotrophy (HP:0007149)1.93448745
101Abnormality of the ischium (HP:0003174)1.93084403
102Ankyloglossia (HP:0010296)1.93036219
103Aortic aneurysm (HP:0004942)1.92501542
104Abnormal delivery (HP:0001787)1.90841839
105Aplasia cutis congenita (HP:0001057)1.89680186
106Poikiloderma (HP:0001029)1.88486549
107Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.87484637
108Dilatation of the ascending aorta (HP:0005111)1.87427239
109Abnormality of sulfur amino acid metabolism (HP:0004339)1.86934697
110Abnormality of dentin (HP:0010299)1.86219661
111Fragile skin (HP:0001030)1.85964011
112Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.85757197
113Vertebral arch anomaly (HP:0008438)1.85370104
114Hepatoblastoma (HP:0002884)1.85174580
115Hypoplastic toenails (HP:0001800)1.85152259
116Abnormality of the acetabulum (HP:0003170)1.85095103
117Abnormal vertebral ossification (HP:0100569)1.84538042
118Absent eyelashes (HP:0000561)1.83623512
119Platyspondyly (HP:0000926)1.82868670
120Relative macrocephaly (HP:0004482)1.82786519
121Upper limb muscle weakness (HP:0003484)1.82005239
122Pseudobulbar signs (HP:0002200)1.81964129
123Cutaneous melanoma (HP:0012056)1.80579993
124Sparse eyelashes (HP:0000653)1.79957896
125Vertebral clefting (HP:0008428)1.79655962
126Impaired proprioception (HP:0010831)1.79297664
127Facial cleft (HP:0002006)1.78791260
128Wormian bones (HP:0002645)1.78639466
129Hepatocellular carcinoma (HP:0001402)1.77990105
130Missing ribs (HP:0000921)1.77355076
131Severe short stature (HP:0003510)1.77159587
132Sensory axonal neuropathy (HP:0003390)1.76445681
133Broad metatarsal (HP:0001783)1.76321110
134Hypoalphalipoproteinemia (HP:0003233)1.76231840
135Myocardial infarction (HP:0001658)1.75968334
136Genu recurvatum (HP:0002816)1.75438825
137Broad face (HP:0000283)1.75069721
138Abnormality of the distal phalanx of the thumb (HP:0009617)1.75056944
139Tetraparesis (HP:0002273)1.75021577
140Delayed epiphyseal ossification (HP:0002663)1.74368973
141Abnormality of the proximal phalanges of the hand (HP:0009834)1.73921067
142Persistence of primary teeth (HP:0006335)1.72616597
143Increased serum pyruvate (HP:0003542)1.71411418
144Bowed forearm bones (HP:0003956)1.71170395
145Bowing of the arm (HP:0006488)1.71170395
146Spastic diplegia (HP:0001264)1.71103912
147Sparse lateral eyebrow (HP:0005338)1.70724052
148Megalocornea (HP:0000485)1.69489589
149Right ventricular cardiomyopathy (HP:0011663)1.69298790
150Abnormality of glutamine family amino acid metabolism (HP:0010902)1.68800564
151Abnormality of the intrinsic pathway (HP:0010989)1.68574354
152Abnormality of the common coagulation pathway (HP:0010990)1.67533115
153Spinal cord lesions (HP:0100561)1.66332267
154Syringomyelia (HP:0003396)1.66332267
155Hyperlipoproteinemia (HP:0010980)1.66040316
156Urethral obstruction (HP:0000796)1.65108357
157Hypoglycemic seizures (HP:0002173)1.63843052
158Epidermoid cyst (HP:0200040)1.63620519
159Papillary thyroid carcinoma (HP:0002895)1.63501115
160Micronodular cirrhosis (HP:0001413)1.62444209
161Ependymoma (HP:0002888)1.62326655
162Pterygium (HP:0001059)1.61576086
163Follicular hyperkeratosis (HP:0007502)1.61334429
164Autoamputation (HP:0001218)1.59778343
165Fragile nails (HP:0001808)1.58758647
166Progressive hearing impairment (HP:0001730)1.56794860
167Secondary amenorrhea (HP:0000869)1.56644263
168Squamous cell carcinoma (HP:0002860)1.55123144
169Spinal cord compression (HP:0002176)1.55113650
170Shoulder girdle muscle weakness (HP:0003547)1.54082055
171Protruding ear (HP:0000411)1.53352707
172Microvesicular hepatic steatosis (HP:0001414)1.52521315

Predicted kinase interactions (KEA)

RankGene SetZ-score
1AKT33.91110008
2ERN13.22046576
3EPHA23.11187806
4DDR23.10375009
5FGFR43.03602484
6TTK2.45055634
7SIK12.40980890
8NEK12.38529963
9PDGFRA2.30427003
10PTK62.17476796
11EPHA32.10408317
12SRPK12.04891893
13TRIB32.02074002
14LATS11.98441916
15PASK1.79748224
16CDK121.77234558
17IRAK31.75757463
18SMG11.73089287
19STK31.72729397
20PKN21.65333618
21BRD41.57359305
22TAF11.53610750
23EPHB11.52205494
24PDGFRB1.48109792
25ERBB41.46619057
26MAP3K101.45866438
27CDC71.43172120
28FRK1.40463998
29FGFR11.38257309
30FGFR21.34460119
31MET1.31859243
32PTK21.30312943
33STK101.28726118
34MTOR1.28036907
35TRIM281.27100877
36FER1.25559816
37EPHB21.25145399
38NME21.24546273
39EEF2K1.23326536
40LATS21.22879658
41TESK11.22382184
42PNCK1.22118969
43MAP3K31.20849555
44BRSK21.19375389
45WNK31.18685416
46TYK21.15461671
47CDK81.11255089
48PAK21.11062565
49STK38L1.09404515
50MST41.05414553
51BRSK11.04986195
52PLK11.03303293
53STK161.00910232
54YES11.00776724
55NTRK11.00615247
56TSSK60.93517649
57CHEK20.92769377
58AURKB0.90766832
59RIPK10.90593524
60PLK30.89756669
61BCR0.89069695
62PAK30.88509091
63LIMK10.88182683
64TTN0.87142221
65LRRK20.85365758
66CAMK1G0.83930031
67PAK40.81459127
68SCYL20.80492733
69LMTK20.79295809
70MAPK150.77853590
71CDK70.77286414
72VRK20.75848950
73CDK40.75514824
74ROCK10.75136380
75FGFR30.74549037
76MELK0.74199464
77EIF2AK20.73132054
78EIF2AK10.72916598
79TGFBR10.72335736
80MKNK20.70701360
81ATR0.69683490
82CAMK1D0.69004308
83DYRK1B0.68993165
84BMX0.67766296
85PBK0.67142800
86CSNK1G10.67030470
87PDK20.66935857
88AURKA0.66730758
89MAP2K10.65798657
90EIF2AK30.64260411
91FLT30.63663495
92MAP2K20.62776411
93CDK90.61381666
94PLK40.61227641
95INSR0.60906327
96CSNK1G30.59681796
97IRAK10.59338426
98ATM0.59252859
99KSR10.58459811
100MKNK10.56814283
101PRKCI0.55659482
102TYRO30.54654851
103STK240.54345890
104MST1R0.54318946
105NEK60.53864000
106MAP3K120.52604018
107MAP3K90.52230589
108AKT20.51796392
109JAK10.51386731
110CDK10.51144259
111ERBB20.50878885
112TESK20.50836994
113BCKDK0.50738128
114MAP3K80.49771255
115SIK30.49564027
116GSK3A0.48838439
117MAP3K20.47653069
118CDK60.46605308
119CHEK10.46487324
120CHUK0.46066241
121MAPK10.44630385
122CSNK1E0.44493761
123ICK0.44000309
124PDK40.43927662
125PDK30.43927662
126EGFR0.43842066
127ALK0.42198434
128IGF1R0.42175161
129NEK90.41707436
130RPS6KB20.41257824
131RPS6KA40.40469826
132JAK30.40180994
133NEK20.39748579
134WEE10.39513105
135CSNK1A1L0.39489508
136ACVR1B0.38686413
137BUB10.38184706
138CDK20.37850082
139SRC0.37655329
140SGK30.35271086
141BMPR1B0.35243934
142PIK3CG0.34790549
143ERBB30.34789185
144CDC42BPA0.34026743

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001202.52932570
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.49357618
3Steroid biosynthesis_Homo sapiens_hsa001002.46392565
4Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.41678295
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.40609499
6Selenocompound metabolism_Homo sapiens_hsa004502.40460323
7Maturity onset diabetes of the young_Homo sapiens_hsa049502.33345287
8Non-homologous end-joining_Homo sapiens_hsa034502.28864406
9DNA replication_Homo sapiens_hsa030302.28130932
10Cell cycle_Homo sapiens_hsa041102.23179240
11Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.23056584
12Proteasome_Homo sapiens_hsa030502.22267975
13Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.21829053
14Sulfur metabolism_Homo sapiens_hsa009202.13359070
15One carbon pool by folate_Homo sapiens_hsa006702.10019135
16Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.07991225
17Complement and coagulation cascades_Homo sapiens_hsa046102.02296973
18Nitrogen metabolism_Homo sapiens_hsa009102.01386243
19Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.01041430
20Tryptophan metabolism_Homo sapiens_hsa003801.95843766
21Fatty acid degradation_Homo sapiens_hsa000711.95523180
22Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.88282130
23Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.80505024
24Nucleotide excision repair_Homo sapiens_hsa034201.71149958
25Mismatch repair_Homo sapiens_hsa034301.70047048
26Spliceosome_Homo sapiens_hsa030401.67358439
27Phenylalanine metabolism_Homo sapiens_hsa003601.65402976
28ECM-receptor interaction_Homo sapiens_hsa045121.65005897
29Arginine biosynthesis_Homo sapiens_hsa002201.61708120
30Histidine metabolism_Homo sapiens_hsa003401.50781227
31Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.48849347
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.46385629
33Fatty acid metabolism_Homo sapiens_hsa012121.44969603
34Vitamin B6 metabolism_Homo sapiens_hsa007501.42367600
35Biosynthesis of amino acids_Homo sapiens_hsa012301.41539685
36Basal transcription factors_Homo sapiens_hsa030221.40203220
37Butanoate metabolism_Homo sapiens_hsa006501.39200521
38Tyrosine metabolism_Homo sapiens_hsa003501.37766183
39Pentose and glucuronate interconversions_Homo sapiens_hsa000401.35451053
40Cysteine and methionine metabolism_Homo sapiens_hsa002701.30572570
41RNA polymerase_Homo sapiens_hsa030201.30279870
42mRNA surveillance pathway_Homo sapiens_hsa030151.30059351
43Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.29020793
44Vibrio cholerae infection_Homo sapiens_hsa051101.27674144
45Lysine degradation_Homo sapiens_hsa003101.27144823
46Folate biosynthesis_Homo sapiens_hsa007901.26586478
47Central carbon metabolism in cancer_Homo sapiens_hsa052301.25981439
48Chemical carcinogenesis_Homo sapiens_hsa052041.25380671
49Steroid hormone biosynthesis_Homo sapiens_hsa001401.24009661
50PPAR signaling pathway_Homo sapiens_hsa033201.23235828
51Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.22479925
52Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.21230901
53Drug metabolism - other enzymes_Homo sapiens_hsa009831.19700523
54Base excision repair_Homo sapiens_hsa034101.18409155
55Peroxisome_Homo sapiens_hsa041461.17798499
56Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.17685823
57Retinol metabolism_Homo sapiens_hsa008301.14147625
58Fat digestion and absorption_Homo sapiens_hsa049751.14139781
59Hippo signaling pathway_Homo sapiens_hsa043901.12248422
60Pentose phosphate pathway_Homo sapiens_hsa000301.08643221
61Pyrimidine metabolism_Homo sapiens_hsa002401.07313845
62Protein digestion and absorption_Homo sapiens_hsa049741.05257113
63N-Glycan biosynthesis_Homo sapiens_hsa005101.05210843
64Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.04241837
65Basal cell carcinoma_Homo sapiens_hsa052171.03735507
66Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.02519377
67Bladder cancer_Homo sapiens_hsa052191.00677672
68Hedgehog signaling pathway_Homo sapiens_hsa043400.98576394
69Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.97043183
70Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.94401092
71Pyruvate metabolism_Homo sapiens_hsa006200.90592041
72Fanconi anemia pathway_Homo sapiens_hsa034600.90320193
73Focal adhesion_Homo sapiens_hsa045100.89524282
74Vitamin digestion and absorption_Homo sapiens_hsa049770.88507572
75Proteoglycans in cancer_Homo sapiens_hsa052050.88387913
76Carbon metabolism_Homo sapiens_hsa012000.87275020
77Sulfur relay system_Homo sapiens_hsa041220.87115291
78Bile secretion_Homo sapiens_hsa049760.86688841
79Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.82379456
80Cyanoamino acid metabolism_Homo sapiens_hsa004600.82358330
81beta-Alanine metabolism_Homo sapiens_hsa004100.81405826
82Pancreatic cancer_Homo sapiens_hsa052120.81077202
83Renal cell carcinoma_Homo sapiens_hsa052110.80560405
84Oocyte meiosis_Homo sapiens_hsa041140.78161157
85Adherens junction_Homo sapiens_hsa045200.77884858
86Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.77599772
87RNA degradation_Homo sapiens_hsa030180.76716002
88Endometrial cancer_Homo sapiens_hsa052130.74019642
89Sphingolipid metabolism_Homo sapiens_hsa006000.73628279
90Fructose and mannose metabolism_Homo sapiens_hsa000510.72520643
91MicroRNAs in cancer_Homo sapiens_hsa052060.72192451
92TGF-beta signaling pathway_Homo sapiens_hsa043500.70410011
93Homologous recombination_Homo sapiens_hsa034400.69205624
94Fatty acid elongation_Homo sapiens_hsa000620.69140018
95Prion diseases_Homo sapiens_hsa050200.68913611
96Galactose metabolism_Homo sapiens_hsa000520.68860906
97Thyroid hormone signaling pathway_Homo sapiens_hsa049190.68744827
98Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.68036185
99Glioma_Homo sapiens_hsa052140.67935807
100Protein export_Homo sapiens_hsa030600.66148272
101Small cell lung cancer_Homo sapiens_hsa052220.65643788
102Propanoate metabolism_Homo sapiens_hsa006400.65448498
103Melanoma_Homo sapiens_hsa052180.64336603
104p53 signaling pathway_Homo sapiens_hsa041150.64082024
105Arginine and proline metabolism_Homo sapiens_hsa003300.63827256
106Starch and sucrose metabolism_Homo sapiens_hsa005000.62763839
1072-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.60399429
108ABC transporters_Homo sapiens_hsa020100.59491112
109Staphylococcus aureus infection_Homo sapiens_hsa051500.58880149
110Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.58181148
111Circadian rhythm_Homo sapiens_hsa047100.57888103
112PI3K-Akt signaling pathway_Homo sapiens_hsa041510.57547398
113Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.54899118
114Chronic myeloid leukemia_Homo sapiens_hsa052200.54466915
115Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.53823483
116Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.52850249
117Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.52393132
118Amoebiasis_Homo sapiens_hsa051460.50298395
119RNA transport_Homo sapiens_hsa030130.50027374
120Colorectal cancer_Homo sapiens_hsa052100.49963936
121Non-small cell lung cancer_Homo sapiens_hsa052230.48857650
122Regulation of actin cytoskeleton_Homo sapiens_hsa048100.47669276
123Wnt signaling pathway_Homo sapiens_hsa043100.47062963
124ErbB signaling pathway_Homo sapiens_hsa040120.46687870
125Prostate cancer_Homo sapiens_hsa052150.46214830
126AMPK signaling pathway_Homo sapiens_hsa041520.45941530
127Legionellosis_Homo sapiens_hsa051340.44957074
128Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.44888870
129Shigellosis_Homo sapiens_hsa051310.44580096
130Insulin resistance_Homo sapiens_hsa049310.44524297
131Thyroid cancer_Homo sapiens_hsa052160.44198388
132Purine metabolism_Homo sapiens_hsa002300.43136833
133Pathways in cancer_Homo sapiens_hsa052000.42446891
134Viral carcinogenesis_Homo sapiens_hsa052030.41914166
135Insulin signaling pathway_Homo sapiens_hsa049100.41462521
136mTOR signaling pathway_Homo sapiens_hsa041500.41399486
137Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.41160899
138Notch signaling pathway_Homo sapiens_hsa043300.39307766
139Glycosaminoglycan degradation_Homo sapiens_hsa005310.38889992
140Antigen processing and presentation_Homo sapiens_hsa046120.37263778
141Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.37114589
142alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.37066305
143Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.34710006
144Glycerolipid metabolism_Homo sapiens_hsa005610.34646643
145Glutathione metabolism_Homo sapiens_hsa004800.34354323
146Tight junction_Homo sapiens_hsa045300.29145792
147Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.28342788

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