FAH

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the last enzyme in the tyrosine catabolism pathway. FAH deficiency is associated with Type 1 hereditary tyrosinemia (HT). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.50705825
2* L-phenylalanine catabolic process (GO:0006559)7.50705825
3* erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.13135392
4* L-phenylalanine metabolic process (GO:0006558)7.13135392
5* aromatic amino acid family catabolic process (GO:0009074)6.63412443
6glyoxylate metabolic process (GO:0046487)5.96865357
7indole-containing compound catabolic process (GO:0042436)5.94523382
8indolalkylamine catabolic process (GO:0046218)5.94523382
9tryptophan catabolic process (GO:0006569)5.94523382
10triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.84466079
11kynurenine metabolic process (GO:0070189)5.74739077
12bile acid biosynthetic process (GO:0006699)5.72752390
13tryptophan metabolic process (GO:0006568)5.60580336
14alpha-linolenic acid metabolic process (GO:0036109)5.46045401
15cysteine metabolic process (GO:0006534)5.46015193
16sulfur amino acid catabolic process (GO:0000098)5.26635513
17urea metabolic process (GO:0019627)5.25433198
18urea cycle (GO:0000050)5.25433198
19negative regulation of fibrinolysis (GO:0051918)5.18966373
20high-density lipoprotein particle remodeling (GO:0034375)5.11087655
21peptidyl-glutamic acid carboxylation (GO:0017187)5.01509830
22protein carboxylation (GO:0018214)5.01509830
23regulation of fibrinolysis (GO:0051917)5.00262033
24serine family amino acid catabolic process (GO:0009071)4.98918125
25complement activation, alternative pathway (GO:0006957)4.91803825
26fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.89286992
27bile acid metabolic process (GO:0008206)4.86861964
28nitrogen cycle metabolic process (GO:0071941)4.86797177
29regulation of protein activation cascade (GO:2000257)4.85470484
30lysine catabolic process (GO:0006554)4.84391769
31lysine metabolic process (GO:0006553)4.84391769
32* aromatic amino acid family metabolic process (GO:0009072)4.75879360
33homocysteine metabolic process (GO:0050667)4.71193788
34regulation of triglyceride catabolic process (GO:0010896)4.59758758
35* alpha-amino acid catabolic process (GO:1901606)4.57017648
36regulation of cholesterol esterification (GO:0010872)4.54437727
37cellular ketone body metabolic process (GO:0046950)4.54213933
38amino-acid betaine metabolic process (GO:0006577)4.53942567
39regulation of complement activation (GO:0030449)4.52846065
40reverse cholesterol transport (GO:0043691)4.46529525
41coenzyme catabolic process (GO:0009109)4.43210605
42plasma lipoprotein particle remodeling (GO:0034369)4.40623117
43protein-lipid complex remodeling (GO:0034368)4.40623117
44macromolecular complex remodeling (GO:0034367)4.40623117
45acylglycerol homeostasis (GO:0055090)4.38338755
46triglyceride homeostasis (GO:0070328)4.38338755
47low-density lipoprotein particle clearance (GO:0034383)4.30863332
48glutamate metabolic process (GO:0006536)4.27536946
49* cellular amino acid catabolic process (GO:0009063)4.26290409
50plasma lipoprotein particle clearance (GO:0034381)4.24517221
51indolalkylamine metabolic process (GO:0006586)4.23673342
52negative regulation of sterol transport (GO:0032372)4.22143412
53negative regulation of cholesterol transport (GO:0032375)4.22143412
54serine family amino acid metabolic process (GO:0009069)4.18423895
55* tyrosine metabolic process (GO:0006570)4.18330842
56cellular biogenic amine catabolic process (GO:0042402)4.18105124
57amine catabolic process (GO:0009310)4.18105124
58phospholipid efflux (GO:0033700)4.12927950
59cellular modified amino acid catabolic process (GO:0042219)4.11486149
60oxaloacetate metabolic process (GO:0006107)4.09166846
61glycine metabolic process (GO:0006544)4.08361893
62drug catabolic process (GO:0042737)4.07085777
63ethanol oxidation (GO:0006069)4.05787109
64serine family amino acid biosynthetic process (GO:0009070)4.04815643
65cellular glucuronidation (GO:0052695)4.03065334
66bile acid and bile salt transport (GO:0015721)4.02181479
67short-chain fatty acid metabolic process (GO:0046459)4.02096560
68aldehyde catabolic process (GO:0046185)4.01959118
69benzene-containing compound metabolic process (GO:0042537)3.99903422
70acetyl-CoA metabolic process (GO:0006084)3.99371011
71triglyceride catabolic process (GO:0019433)3.95620127
72ketone body metabolic process (GO:1902224)3.94637863
73imidazole-containing compound metabolic process (GO:0052803)3.93207371
74cholesterol efflux (GO:0033344)3.92400305
75dicarboxylic acid biosynthetic process (GO:0043650)3.87728433
76omega-hydroxylase P450 pathway (GO:0097267)3.86366764
77drug transmembrane transport (GO:0006855)3.85922906
78aspartate family amino acid catabolic process (GO:0009068)3.84348460
79cofactor catabolic process (GO:0051187)3.80852341
80* organic acid catabolic process (GO:0016054)3.78942777
81* carboxylic acid catabolic process (GO:0046395)3.78942777
82epoxygenase P450 pathway (GO:0019373)3.78183309
83fibrinolysis (GO:0042730)3.77775344
84urate metabolic process (GO:0046415)3.72493493
85neutral lipid catabolic process (GO:0046461)3.68776049
86acylglycerol catabolic process (GO:0046464)3.68776049
87positive regulation of lipoprotein lipase activity (GO:0051006)3.67434683
88positive regulation of triglyceride lipase activity (GO:0061365)3.67434683
89low-density lipoprotein particle remodeling (GO:0034374)3.67272501
90plasma lipoprotein particle assembly (GO:0034377)3.64119441
91glucuronate metabolic process (GO:0019585)3.64024159
92uronic acid metabolic process (GO:0006063)3.64024159
93exogenous drug catabolic process (GO:0042738)3.63473593
94cholesterol homeostasis (GO:0042632)3.61994234
95heme transport (GO:0015886)3.61790016
96regulation of bile acid biosynthetic process (GO:0070857)3.61436228
97fatty acid beta-oxidation (GO:0006635)3.59540213
98negative regulation of lipase activity (GO:0060192)3.59387705
99monocarboxylic acid catabolic process (GO:0072329)3.58531845
100negative regulation of blood coagulation (GO:0030195)3.58248277
101negative regulation of hemostasis (GO:1900047)3.58248277
102fatty acid oxidation (GO:0019395)3.57615085
103sterol homeostasis (GO:0055092)3.56986564
104regulation of cholesterol homeostasis (GO:2000188)3.55910346
105positive regulation of lipid catabolic process (GO:0050996)3.53449796
106very long-chain fatty acid metabolic process (GO:0000038)3.52372234
107phospholipid homeostasis (GO:0055091)3.51513846
108lipid oxidation (GO:0034440)3.50929725
109blood coagulation, intrinsic pathway (GO:0007597)3.49168558
110regulation of plasminogen activation (GO:0010755)3.38266899
111ethanol metabolic process (GO:0006067)3.37956898
112NADH metabolic process (GO:0006734)3.37746082
113negative regulation of coagulation (GO:0050819)3.36659686
114polyketide metabolic process (GO:0030638)3.31814451
115doxorubicin metabolic process (GO:0044598)3.31814451
116daunorubicin metabolic process (GO:0044597)3.31814451
117xenobiotic catabolic process (GO:0042178)3.29074974
118positive regulation of blood coagulation (GO:0030194)3.27038480
119positive regulation of hemostasis (GO:1900048)3.27038480
120acute-phase response (GO:0006953)3.08642397
121positive regulation of coagulation (GO:0050820)3.06826740
122negative regulation of wound healing (GO:0061045)3.05257964
123drug metabolic process (GO:0017144)3.03459474
124positive regulation of fatty acid biosynthetic process (GO:0045723)3.01724246
125protein activation cascade (GO:0072376)2.99600531
126valine metabolic process (GO:0006573)2.97773181
127aminoglycoside antibiotic metabolic process (GO:0030647)2.94933851
128proline metabolic process (GO:0006560)2.91801763
129pentose-phosphate shunt (GO:0006098)2.89504304
130proline biosynthetic process (GO:0006561)2.86034356
131regulation of sterol transport (GO:0032371)2.77947940
132regulation of cholesterol transport (GO:0032374)2.77947940
133NADPH regeneration (GO:0006740)2.70993654
134tricarboxylic acid metabolic process (GO:0072350)2.70830628
135fatty acid catabolic process (GO:0009062)2.68435061
136primary alcohol metabolic process (GO:0034308)2.63809689
137fatty acid homeostasis (GO:0055089)2.63298165
138tetrahydrofolate metabolic process (GO:0046653)2.62535497
139complement activation (GO:0006956)2.59874149
140glycoside metabolic process (GO:0016137)2.58009002
141triglyceride metabolic process (GO:0006641)2.55636060
142negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.54234511
143branched-chain amino acid metabolic process (GO:0009081)2.54093367
144acute inflammatory response (GO:0002526)2.53066691
145biotin metabolic process (GO:0006768)2.51139012

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse7.99454026
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.78848152
3* EGR1_23403033_ChIP-Seq_LIVER_Mouse6.47152340
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.23460809
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.05355932
6* PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.95781742
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.72279454
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.86490112
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.74316860
10EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.02461553
11E2F7_22180533_ChIP-Seq_HELA_Human2.20534542
12* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.05205607
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.01605263
14ELF1_17652178_ChIP-ChIP_JURKAT_Human2.00563957
15* ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.2907247
16TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.98605150
17HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.90451833
18RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.84236361
19SRF_21415370_ChIP-Seq_HL-1_Mouse1.82153876
20MYC_18358816_ChIP-ChIP_MESCs_Mouse1.78374793
21KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.78068179
22SCL_19346495_ChIP-Seq_HPC-7_Human1.77128191
23BP1_19119308_ChIP-ChIP_Hs578T_Human1.74066177
24CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.69084323
25FOXA2_19822575_ChIP-Seq_HepG2_Human1.65764592
26NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.63421998
27CLOCK_20551151_ChIP-Seq_293T_Human1.62214125
28HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.60266438
29MYC_18555785_ChIP-Seq_MESCs_Mouse1.53608854
30HTT_18923047_ChIP-ChIP_STHdh_Human1.51817795
31SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.48760795
32SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.48320391
33LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.46565163
34FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.46491480
35HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.43742253
36GATA1_22383799_ChIP-Seq_G1ME_Mouse1.43176518
37MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.39691332
38TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.37576984
39* HNF4A_19822575_ChIP-Seq_HepG2_Human1.36934850
40HOXB4_20404135_ChIP-ChIP_EML_Mouse1.36678892
41TFEB_21752829_ChIP-Seq_HELA_Human1.35076927
42E2F1_18555785_ChIP-Seq_MESCs_Mouse1.33336039
43TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.33137685
44VDR_21846776_ChIP-Seq_THP-1_Human1.32763863
45PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.32357560
46MYB_21317192_ChIP-Seq_ERMYB_Mouse1.31963458
47ELK3_25401928_ChIP-Seq_HUVEC_Human1.29702231
48DCP1A_22483619_ChIP-Seq_HELA_Human1.28248260
49STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.26471372
50NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.25048548
51LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.24160929
52* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.24159924
53THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.21651076
54PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.20446370
55MYC_19030024_ChIP-ChIP_MESCs_Mouse1.19638550
56NCOR1_26117541_ChIP-Seq_K562_Human1.18411313
57GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.17681059
58ETS1_20019798_ChIP-Seq_JURKAT_Human1.16770442
59ERG_20887958_ChIP-Seq_HPC-7_Mouse1.16232334
60SPI1_23547873_ChIP-Seq_NB4_Human1.14907999
61GATA1_22025678_ChIP-Seq_K562_Human1.13129828
62NELFA_20434984_ChIP-Seq_ESCs_Mouse1.12888743
63TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.12596249
64PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.11747187
65IRF8_21731497_ChIP-ChIP_J774_Mouse1.11601924
66ELF1_20517297_ChIP-Seq_JURKAT_Human1.11395442
67SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.10413531
68ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.09941129
69STAT4_19710469_ChIP-ChIP_TH1__Mouse1.09598673
70TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.08517279
71THAP11_20581084_ChIP-Seq_MESCs_Mouse1.08224053
72RXRA_24833708_ChIP-Seq_LIVER_Mouse1.07580194
73* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.05953660
74VDR_24763502_ChIP-Seq_THP-1_Human1.05233467
75RUNX1_22412390_ChIP-Seq_EML_Mouse1.05167605
76GABP_17652178_ChIP-ChIP_JURKAT_Human1.04947734
77* GATA1_19941827_ChIP-Seq_MEL_Mouse1.04919074
78BRD4_27068464_Chip-Seq_AML-cells_Mouse1.04708415
79GATA2_22383799_ChIP-Seq_G1ME_Mouse1.04543647
80SOX2_27498859_Chip-Seq_STOMACH_Mouse1.03609698
81BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.02481226
82SPI1_23127762_ChIP-Seq_K562_Human1.01548210
83ZFX_18555785_ChIP-Seq_MESCs_Mouse1.01074331
84CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.01022120
85SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.00368357
86CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.00155525
87RARG_19884340_ChIP-ChIP_MEFs_Mouse1.00089973
88CREB1_15753290_ChIP-ChIP_HEK293T_Human0.99883119
89TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.99857436
90DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.99586928
91SPI1_20517297_ChIP-Seq_HL60_Human0.99269127
92MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.97796224
93ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.96058829
94EST1_17652178_ChIP-ChIP_JURKAT_Human0.95889075
95SRY_22984422_ChIP-ChIP_TESTIS_Rat0.95277249
96IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.93614811
97TET1_21451524_ChIP-Seq_MESCs_Mouse0.93192969
98ESR2_21235772_ChIP-Seq_MCF-7_Human0.92350039
99ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.91388732
100AUTS2_25519132_ChIP-Seq_293T-REX_Human0.88036072
101ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.87272095
102NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.86349543
103NRF2_20460467_ChIP-Seq_MEFs_Mouse0.86349543
104STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.85918020
105GATA4_25053715_ChIP-Seq_YYC3_Human0.85396250
106BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.83918186
107SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.80506092
108IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.78311852
109AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.77407250
110SALL4_18804426_ChIP-ChIP_XEN_Mouse0.72508326
111* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.70105513
112ESR1_15608294_ChIP-ChIP_MCF-7_Human0.69933552
113E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.69683730
114Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.69675859
115RAD21_21589869_ChIP-Seq_MESCs_Mouse0.69060750
116KAP1_22055183_ChIP-Seq_ESCs_Mouse0.66886488
117PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.64776347
118SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.63877129
119ZNF263_19887448_ChIP-Seq_K562_Human0.63738692
120RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.63639133
121ESR1_21235772_ChIP-Seq_MCF-7_Human0.62340131
122* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.62252968
123TAF15_26573619_Chip-Seq_HEK293_Human0.61573279
124NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.61100047
125CEBPB_22108803_ChIP-Seq_LS180_Human0.60873121
126FOXA1_25552417_ChIP-Seq_VCAP_Human0.60439771
127PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.60201851
128RARA_24833708_ChIP-Seq_LIVER_Mouse0.60055154
129MYC_19915707_ChIP-ChIP_AK7_Human0.59029942
130FOXO3_23340844_ChIP-Seq_DLD1_Human0.58989520
131CBP_21632823_ChIP-Seq_H3396_Human0.58888158
132NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.56594171
133RARB_24833708_ChIP-Seq_LIVER_Mouse0.55901310
134* BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.55185878
135PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.53669082
136PPAR_26484153_Chip-Seq_NCI-H1993_Human0.53392052
137LXR_22292898_ChIP-Seq_THP-1_Human0.52869790
138FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.52596842
139ESET_19884257_ChIP-Seq_ESCs_Mouse0.52190037
140ESR1_20079471_ChIP-ChIP_T-47D_Human0.52041010
141GATA1_19941826_ChIP-Seq_K562_Human0.51574758
142IRF8_22096565_ChIP-ChIP_GC-B_Human0.50962140
143EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.50922267
144AR_20517297_ChIP-Seq_VCAP_Human0.50842854
145ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.50225675
146ERG_21242973_ChIP-ChIP_JURKAT_Human0.50222760
147P53_21459846_ChIP-Seq_SAOS-2_Human0.48890403
148CDX2_20551321_ChIP-Seq_CACO-2_Human0.48244424
149TRIM28_21343339_ChIP-Seq_HEK293_Human0.48043480
150STAT1_17558387_ChIP-Seq_HELA_Human0.47348753
151SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.46988183
152SOX2_20726797_ChIP-Seq_SW620_Human0.46165854
153TAF2_19829295_ChIP-Seq_ESCs_Human0.45627785
154ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.44681053
155* PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.44544088
156GATA2_19941826_ChIP-Seq_K562_Human0.43988530
157SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.43013106
158* EGR1_19032775_ChIP-ChIP_M12_Human0.42972123
159PIAS1_25552417_ChIP-Seq_VCAP_Human0.42303868
160NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.41744911
161FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.40908566
162* P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.40028924
163CDX2_22108803_ChIP-Seq_LS180_Human0.39953326
164FOXH1_21741376_ChIP-Seq_EPCs_Human0.39941844
165* NCOR_22424771_ChIP-Seq_293T_Human0.39768886
166* OCT4_20526341_ChIP-Seq_ESCs_Human0.39517557
167GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.39240143
168PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.39172728
169CSB_26484114_Chip-Seq_FIBROBLAST_Human0.39006388
170GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.38813893

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.04397526
2MP0005360_urolithiasis7.60990760
3MP0005085_abnormal_gallbladder_physiolo6.11886291
4MP0005365_abnormal_bile_salt5.88820989
5MP0008875_abnormal_xenobiotic_pharmacok5.02240664
6MP0003806_abnormal_nucleotide_metabolis4.36452377
7MP0003252_abnormal_bile_duct3.72587011
8MP0010329_abnormal_lipoprotein_level3.41806137
9MP0009840_abnormal_foam_cell3.17498643
10MP0003195_calcinosis3.13642413
11* MP0005332_abnormal_amino_acid2.98368992
12MP0005083_abnormal_biliary_tract2.96312931
13MP0001666_abnormal_nutrient_absorption2.50699393
14MP0004019_abnormal_vitamin_homeostasis2.36510802
15MP0003191_abnormal_cellular_cholesterol2.33771520
16MP0002118_abnormal_lipid_homeostasis2.15842825
17* MP0000609_abnormal_liver_physiology2.01832318
18MP0002138_abnormal_hepatobiliary_system2.00335582
19MP0000343_altered_response_to1.78781107
20MP0005319_abnormal_enzyme/_coenzyme1.78080283
21MP0003868_abnormal_feces_composition1.71446667
22MP0005584_abnormal_enzyme/coenzyme_acti1.67104540
23MP0005451_abnormal_body_composition1.66402340
24MP0001545_abnormal_hematopoietic_system1.62528008
25MP0005397_hematopoietic_system_phenotyp1.62528008
26MP0001764_abnormal_homeostasis1.62347849
27* MP0009643_abnormal_urine_homeostasis1.44906689
28MP0003186_abnormal_redox_activity1.44278311
29MP0002877_abnormal_melanocyte_morpholog1.42341427
30MP0002132_abnormal_respiratory_system1.39507636
31MP0008438_abnormal_cutaneous_collagen1.38036618
32MP0003011_delayed_dark_adaptation1.36030719
33MP0003950_abnormal_plasma_membrane1.34775387
34MP0009697_abnormal_copulation1.27965258
35MP0000858_altered_metastatic_potential1.23967071
36MP0003656_abnormal_erythrocyte_physiolo1.22880583
37MP0000372_irregular_coat_pigmentation1.18635482
38MP0000604_amyloidosis1.18017927
39MP0008007_abnormal_cellular_replicative1.11258700
40MP0002148_abnormal_hypersensitivity_rea1.10849416
41MP0005636_abnormal_mineral_homeostasis1.10099427
42MP0003303_peritoneal_inflammation1.07251681
43* MP0000598_abnormal_liver_morphology1.05734378
44MP0005670_abnormal_white_adipose1.04853930
45MP0005647_abnormal_sex_gland1.03471912
46MP0009785_altered_susceptibility_to1.03463563
47MP0003690_abnormal_glial_cell0.98714815
48MP0009333_abnormal_splenocyte_physiolog0.98131850
49MP0003705_abnormal_hypodermis_morpholog0.97588106
50MP0009764_decreased_sensitivity_to0.96860868
51MP0003172_abnormal_lysosome_physiology0.96778964
52MP0003436_decreased_susceptibility_to0.95654094
53MP0002419_abnormal_innate_immunity0.94891623
54MP0003329_amyloid_beta_deposits0.94828752
55MP0003566_abnormal_cell_adhesion0.94752999
56MP0002254_reproductive_system_inflammat0.93275041
57MP0006036_abnormal_mitochondrial_physio0.93145227
58MP0005408_hypopigmentation0.92837676
59MP0002876_abnormal_thyroid_physiology0.89689042
60MP0005023_abnormal_wound_healing0.89520556
61* MP0009763_increased_sensitivity_to0.89265944
62MP0005164_abnormal_response_to0.87174297
63MP0001661_extended_life_span0.86193298
64MP0004043_abnormal_pH_regulation0.84782715
65* MP0009642_abnormal_blood_homeostasis0.84452524
66MP0000003_abnormal_adipose_tissue0.83928799
67MP0005084_abnormal_gallbladder_morpholo0.82688084
68MP0008469_abnormal_protein_level0.82628243
69MP0003828_pulmonary_edema0.81147718
70MP0010368_abnormal_lymphatic_system0.80686356
71MP0001756_abnormal_urination0.80667802
72MP0002971_abnormal_brown_adipose0.80219851
73MP0005535_abnormal_body_temperature0.78903179
74MP0004130_abnormal_muscle_cell0.78347101
75MP0008004_abnormal_stomach_pH0.77612926
76MP0001853_heart_inflammation0.77606138
77MP0005376_homeostasis/metabolism_phenot0.77196186
78MP0001835_abnormal_antigen_presentation0.76418938
79MP0000371_diluted_coat_color0.76109534
80* MP0002078_abnormal_glucose_homeostasis0.74807303
81MP0005410_abnormal_fertilization0.74711554
82MP0005025_abnormal_response_to0.72456152
83* MP0001845_abnormal_inflammatory_respons0.70269804
84MP0008260_abnormal_autophagy0.70009997
85MP0001533_abnormal_skeleton_physiology0.69743337
86MP0005334_abnormal_fat_pad0.69735534
87MP0000685_abnormal_immune_system0.67574662
88MP0005666_abnormal_adipose_tissue0.64299455
89MP0005220_abnormal_exocrine_pancreas0.63804731
90* MP0009765_abnormal_xenobiotic_induced0.63671860
91MP0005167_abnormal_blood-brain_barrier0.62280090
92MP0004272_abnormal_basement_membrane0.62277678
93MP0000358_abnormal_cell_content/0.62038454
94MP0005266_abnormal_metabolism0.61907777
95MP0000689_abnormal_spleen_morphology0.60382295
96MP0005000_abnormal_immune_tolerance0.59535276
97* MP0002136_abnormal_kidney_physiology0.59077643
98MP0000639_abnormal_adrenal_gland0.58090442
99MP0005058_abnormal_lysosome_morphology0.57258537
100MP0002837_dystrophic_cardiac_calcinosis0.55697414
101MP0006035_abnormal_mitochondrial_morpho0.53984508
102MP0005448_abnormal_energy_balance0.53739662
103MP0005395_other_phenotype0.52878230
104MP0000920_abnormal_myelination0.51476138
105MP0008874_decreased_physiological_sensi0.48582532
106MP0003638_abnormal_response/metabolism_0.48021160
107MP0002822_catalepsy0.46753243
108MP0002796_impaired_skin_barrier0.46686348
109MP0000230_abnormal_systemic_arterial0.46002947
110MP0003075_altered_response_to0.45079777
111MP0001765_abnormal_ion_homeostasis0.44497330
112MP0003724_increased_susceptibility_to0.43263379
113MP0009053_abnormal_anal_canal0.42712467
114MP0002168_other_aberrant_phenotype0.42288333
115MP0004381_abnormal_hair_follicle0.42197296
116MP0008873_increased_physiological_sensi0.41607927
117MP0003718_maternal_effect0.41590112
118MP0003953_abnormal_hormone_level0.40565673
119MP0008872_abnormal_physiological_respon0.39720537
120MP0000579_abnormal_nail_morphology0.38890382
121MP0002928_abnormal_bile_duct0.38054448
122MP0004782_abnormal_surfactant_physiolog0.37387323
123MP0009384_cardiac_valve_regurgitation0.36861740
124MP0005464_abnormal_platelet_physiology0.34097749
125MP0002295_abnormal_pulmonary_circulatio0.33653342
126MP0006082_CNS_inflammation0.32879400
127MP0009115_abnormal_fat_cell0.32526648
128MP0009672_abnormal_birth_weight0.32149872
129MP0001881_abnormal_mammary_gland0.31951894
130MP0004185_abnormal_adipocyte_glucose0.31587691
131MP0005166_decreased_susceptibility_to0.30952795
132MP0002970_abnormal_white_adipose0.30232408
133MP0001243_abnormal_dermal_layer0.29981246
134MP0000249_abnormal_blood_vessel0.28957515
135MP0003959_abnormal_lean_body0.28570394
136MP0004147_increased_porphyrin_level0.28019614
137MP0005375_adipose_tissue_phenotype0.26763154

Predicted human phenotypes

RankGene SetZ-score
1* Abnormality of aromatic amino acid family metabolism (HP:0004338)6.98479603
2Intrahepatic cholestasis (HP:0001406)6.97081104
3Deep venous thrombosis (HP:0002625)6.94188503
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.24900617
5Xanthomatosis (HP:0000991)6.15985426
6Prolonged partial thromboplastin time (HP:0003645)6.02926367
7Hypobetalipoproteinemia (HP:0003563)5.81886974
8Hyperlipoproteinemia (HP:0010980)5.44161832
9Complement deficiency (HP:0004431)4.92911612
10Hyperammonemia (HP:0001987)4.67638771
11Hyperglycinemia (HP:0002154)4.51000886
12Ketosis (HP:0001946)4.48724589
13Hypolipoproteinemia (HP:0010981)4.42807334
14Abnormality of glutamine family amino acid metabolism (HP:0010902)4.42662864
15Joint hemorrhage (HP:0005261)4.42379862
16Hyperglycinuria (HP:0003108)4.34152372
17Abnormality of glycine metabolism (HP:0010895)4.34016136
18Abnormality of serine family amino acid metabolism (HP:0010894)4.34016136
19Epidermoid cyst (HP:0200040)4.32399517
20Purpura (HP:0000979)4.17867572
21Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.12823985
22Abnormality of the common coagulation pathway (HP:0010990)4.10167528
23Hypoalphalipoproteinemia (HP:0003233)3.95131071
24Fat malabsorption (HP:0002630)3.92714652
25* Abnormality of sulfur amino acid metabolism (HP:0004339)3.88330410
26* Abnormality of aspartate family amino acid metabolism (HP:0010899)3.86895496
27Hypoglycemic coma (HP:0001325)3.79050324
28Increased mean platelet volume (HP:0011877)3.66194741
29Abnormality of fatty-acid metabolism (HP:0004359)3.65101296
30* Abnormality of methionine metabolism (HP:0010901)3.57141566
31Petechiae (HP:0000967)3.53946194
32Abnormality of complement system (HP:0005339)3.51698492
33Conjugated hyperbilirubinemia (HP:0002908)3.48409044
34Prolonged bleeding time (HP:0003010)3.46307132
35Abnormality of pyrimidine metabolism (HP:0004353)3.45689673
36Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.43464207
37Abnormality of the intrinsic pathway (HP:0010989)3.40219190
38Abnormal platelet volume (HP:0011876)3.36558170
39Ketoacidosis (HP:0001993)3.35381893
40Hypercholesterolemia (HP:0003124)3.33937178
41Delayed CNS myelination (HP:0002188)3.22652427
42Abnormality of nucleobase metabolism (HP:0010932)3.15453561
43Hyperbilirubinemia (HP:0002904)3.15417248
44Epistaxis (HP:0000421)3.13405270
45Abnormality of serum amino acid levels (HP:0003112)3.11083063
46Gout (HP:0001997)3.04814629
47Steatorrhea (HP:0002570)3.02626299
48Abnormality of purine metabolism (HP:0004352)3.00335504
49Hypertriglyceridemia (HP:0002155)2.98287691
50Abnormal platelet function (HP:0011869)2.96436496
51Impaired platelet aggregation (HP:0003540)2.96436496
52Metabolic acidosis (HP:0001942)2.93701667
53Vascular calcification (HP:0004934)2.90363189
54Dicarboxylic aciduria (HP:0003215)2.86198311
55Abnormality of dicarboxylic acid metabolism (HP:0010995)2.86198311
56Abnormality of glycolysis (HP:0004366)2.84084860
57Nausea (HP:0002018)2.81817153
58Lethargy (HP:0001254)2.81519925
59Increased serum pyruvate (HP:0003542)2.80491742
60Spontaneous abortion (HP:0005268)2.76136050
61Myocardial infarction (HP:0001658)2.73162665
62Abnormality of liposaccharide metabolism (HP:0010968)2.73133089
63Abnormality of glycosphingolipid metabolism (HP:0004343)2.73133089
64Abnormality of glycolipid metabolism (HP:0010969)2.73133089
65Cerebral edema (HP:0002181)2.67339205
66Skin nodule (HP:0200036)2.63450298
67Cardiovascular calcification (HP:0011915)2.58684988
68Vacuolated lymphocytes (HP:0001922)2.58591948
69Increased serum ferritin (HP:0003281)2.58152034
70Hepatosplenomegaly (HP:0001433)2.57267107
71Systemic lupus erythematosus (HP:0002725)2.55398519
72Vertebral compression fractures (HP:0002953)2.54390307
73Hypochromic microcytic anemia (HP:0004840)2.52311120
74Irritability (HP:0000737)2.50451959
75Generalized aminoaciduria (HP:0002909)2.45237281
76Abnormal gallbladder morphology (HP:0012437)2.42305566
77Alkalosis (HP:0001948)2.40059041
78Amyloidosis (HP:0011034)2.37956460
79Malnutrition (HP:0004395)2.36147271
80Hypoglycemic seizures (HP:0002173)2.35261913
81Spastic diplegia (HP:0001264)2.34670636
82Dysostosis multiplex (HP:0000943)2.34645450
83Cholecystitis (HP:0001082)2.34596622
84Abnormal gallbladder physiology (HP:0012438)2.34596622
85Vomiting (HP:0002013)2.33766845
86Cholelithiasis (HP:0001081)2.33454217
87* Hepatocellular carcinoma (HP:0001402)2.31135046
88Mitral stenosis (HP:0001718)2.30915717
89Rhabdomyolysis (HP:0003201)2.30682454
90Neonatal onset (HP:0003623)2.30028012
91Nephritis (HP:0000123)2.28163561
92Reduced antithrombin III activity (HP:0001976)2.27095347
93Polycythemia (HP:0001901)2.26369046
94Acanthocytosis (HP:0001927)2.24247194
95Proximal tubulopathy (HP:0000114)2.21166205
96Increased muscle lipid content (HP:0009058)2.20451031
97Glomerulonephritis (HP:0000099)2.19339902
98Pancreatitis (HP:0001733)2.18982708
99Reticulocytosis (HP:0001923)2.17417648
100Brushfield spots (HP:0001088)2.16821355
101Abnormality of proline metabolism (HP:0010907)2.16111844
102Hydroxyprolinuria (HP:0003080)2.16111844
103Opisthotonus (HP:0002179)2.15661674
104Hyperuricemia (HP:0002149)2.15525811
105Increased purine levels (HP:0004368)2.15525811
106Sensorimotor neuropathy (HP:0007141)2.11648112
107Glycosuria (HP:0003076)2.06346009
108Abnormality of urine glucose concentration (HP:0011016)2.06346009
109Poikilocytosis (HP:0004447)2.04878170
110Abnormal pupillary function (HP:0007686)2.04213278
111Abnormality of mucopolysaccharide metabolism (HP:0011020)2.03949157
112Abnormality of polysaccharide metabolism (HP:0011012)2.03949157
113Abnormality of glycosaminoglycan metabolism (HP:0004371)2.03949157
114Mucopolysacchariduria (HP:0008155)2.02515426
115Urinary glycosaminoglycan excretion (HP:0003541)2.02515426
116Late onset (HP:0003584)2.02040000
117Abnormal enzyme/coenzyme activity (HP:0012379)1.99018337
118Hemorrhage of the eye (HP:0011885)1.98821599
119Esophageal varix (HP:0002040)1.97136351
120Abnormality of the gallbladder (HP:0005264)1.96751866
121Gingival bleeding (HP:0000225)1.94340214
122Hyperinsulinemic hypoglycemia (HP:0000825)1.92979179
123Abnormality of alanine metabolism (HP:0010916)1.92085183
124Hyperalaninemia (HP:0003348)1.92085183
125Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.92085183
126Hepatic necrosis (HP:0002605)1.90216263
127Menorrhagia (HP:0000132)1.89250384
128Prolonged neonatal jaundice (HP:0006579)1.89022699
129Recurrent gram-negative bacterial infections (HP:0005420)1.88883399
130Acute encephalopathy (HP:0006846)1.87361726
131Thrombophlebitis (HP:0004418)1.86132342
132Increased cerebral lipofuscin (HP:0011813)1.86009106
133Abnormal cartilage morphology (HP:0002763)1.84954645
134Abnormality of vitamin metabolism (HP:0100508)1.84754330
135Type I transferrin isoform profile (HP:0003642)1.82640500
136* Rickets (HP:0002748)1.81812413
137Abnormality of transition element cation homeostasis (HP:0011030)1.81805122
138Abnormality of iron homeostasis (HP:0011031)1.81802141
139* Abnormality of the heme biosynthetic pathway (HP:0010472)1.81422005
140Confusion (HP:0001289)1.80094428
141Renal cortical cysts (HP:0000803)1.79121691
142Abnormality of the Achilles tendon (HP:0005109)1.76559545
143Elevated alkaline phosphatase (HP:0003155)1.75992976
144Back pain (HP:0003418)1.75213850
145Acanthosis nigricans (HP:0000956)1.74329964
146Increased intramyocellular lipid droplets (HP:0012240)1.73529130
147Increased neuronal autofluorescent lipopigment (HP:0002074)1.72349280
148Hypertensive crisis (HP:0100735)1.69811066
149Thrombocytosis (HP:0001894)1.69444272
150Abnormal mitochondria in muscle tissue (HP:0008316)1.69066263

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.19600810
2SIK14.14457439
3FGFR44.13234000
4NME23.67843826
5ERN13.65103336
6EIF2AK12.97063880
7INSRR2.90414753
8ERBB42.68666511
9TESK12.38250974
10OXSR12.30704951
11EPHB12.29365443
12VRK22.29212930
13TAOK32.23306045
14MYLK2.14873713
15STK392.13969771
16TAOK22.13217389
17MST1R2.11878975
18WNK42.11748511
19PIM22.09496623
20FGFR21.97413490
21SCYL21.94672767
22MAPKAPK31.83700657
23MAP2K41.83576826
24MST41.81420565
25MET1.76361802
26TESK21.62904398
27ARAF1.61876595
28MAPK111.55353184
29RIPK41.49568317
30ILK1.48544211
31PIK3CG1.45614007
32ABL21.45064512
33LATS11.36605020
34STK161.35379243
35TRIB31.34650977
36DAPK21.30829094
37PKN21.30548074
38PINK11.28904088
39FLT31.27847280
40PAK41.25797249
41MATK1.22150881
42WNK31.19842135
43TYK21.17799808
44SMG11.17618484
45PTK61.17451570
46IKBKB1.16371566
47PKN11.15750403
48PRPF4B1.14542686
49PRKAA21.13637047
50BUB11.12248654
51MAP3K71.09423028
52DAPK31.08753217
53ZAP701.04746996
54KDR1.04276583
55STK38L1.00440056
56JAK20.98387672
57SGK4940.97969541
58SGK2230.97969541
59PBK0.96820401
60MAPK150.95348193
61BMPR20.94843422
62PAK10.93475790
63CAMK2G0.92797638
64NEK90.92089758
65TIE10.91545698
66BLK0.90170631
67JAK30.89135389
68CLK10.89001945
69GSK3A0.88994163
70CAMK1D0.87886610
71DDR20.87317880
72PRKCZ0.85918462
73VRK10.85134678
74ERBB20.83822659
75GRK60.83432414
76FRK0.83197589
77MUSK0.81375518
78MAPK40.80512662
79CSNK1G10.79570435
80MAPK120.77795151
81PDPK10.77678797
82BTK0.77379990
83KIT0.77207696
84EIF2AK30.77036122
85TLK10.75459824
86JAK10.73915147
87MAP3K140.73757488
88PRKACG0.72920973
89MAP3K80.72117635
90TRPM70.71230359
91EPHA30.71153916
92TEC0.68626845
93TBK10.68391302
94PRKCQ0.67454716
95PTK20.65675325
96CSNK1G30.64925465
97ICK0.64216966
98CCNB10.63267217
99GRK50.63081575
100CSK0.60310064
101TNK20.59900084
102PRKAA10.59363649
103SYK0.59295164
104EPHA40.58371887
105CDK90.58230343
106MAP2K30.57449659
107PAK30.57079157
108CSNK1A1L0.56578223
109DAPK10.56115519
110NUAK10.56013418
111NTRK10.55274877
112PDK30.54898210
113PDK40.54898210
114MAP3K30.54805533
115DYRK1B0.54802255
116PAK20.54689365
117NEK10.54612264
118CAMK1G0.54602846
119CDK70.53336024
120CSNK1G20.52232133
121ZAK0.51798224
122MAPK70.49351253
123CDK80.49351003
124MAP3K130.49258547
125SGK30.48582292
126RPS6KB20.48142597
127LMTK20.45911616
128MOS0.44965714
129TTK0.42822780
130MAP3K110.42309679
131CSF1R0.41325827
132LIMK10.41185749
133RAF10.40926600
134MAP2K10.40898496
135PDK10.40748406
136FER0.40064816
137AURKA0.39851295
138RET0.39783523
139LYN0.39655983
140IGF1R0.39359384
141IRAK20.39328075
142MAP2K20.38697121
143EEF2K0.38393817
144STK40.38374642
145TGFBR20.38209743
146MAP2K60.37996948
147GRK10.37902167
148PRKD10.37559987
149CDK60.36434927
150BMX0.36398174
151IRAK10.35073076
152MAPKAPK50.35028965
153AKT20.34511850
154BRAF0.33489322
155RIPK10.32251157
156CAMK2B0.31625188
157IRAK30.30176730
158PDK20.29874381
159PRKCG0.29387143
160PIK3CA0.29226290
161BCR0.28982773
162SGK20.28450957
163PRKCA0.27958824
164IKBKE0.27770666

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.18414425
2Nitrogen metabolism_Homo sapiens_hsa009103.45483101
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.20599238
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.17148159
5Arginine biosynthesis_Homo sapiens_hsa002202.90061387
6Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.81766402
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.70149008
8Tryptophan metabolism_Homo sapiens_hsa003802.63718494
9Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.60613243
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.59317113
11Fatty acid degradation_Homo sapiens_hsa000712.50282848
12Complement and coagulation cascades_Homo sapiens_hsa046102.48497222
13Butanoate metabolism_Homo sapiens_hsa006502.38817692
14Pentose and glucuronate interconversions_Homo sapiens_hsa000402.18835413
15Propanoate metabolism_Homo sapiens_hsa006402.17251569
16Peroxisome_Homo sapiens_hsa041462.16843298
17Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.09510483
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.05736123
19Histidine metabolism_Homo sapiens_hsa003401.96332583
20Fatty acid metabolism_Homo sapiens_hsa012121.94005917
21PPAR signaling pathway_Homo sapiens_hsa033201.88691691
22Chemical carcinogenesis_Homo sapiens_hsa052041.85888341
23Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.84668816
24Steroid hormone biosynthesis_Homo sapiens_hsa001401.83938028
25beta-Alanine metabolism_Homo sapiens_hsa004101.74996915
26Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.70128805
27Fatty acid elongation_Homo sapiens_hsa000621.69934118
282-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.61461331
29Other glycan degradation_Homo sapiens_hsa005111.60443082
30Caffeine metabolism_Homo sapiens_hsa002321.60311380
31Retinol metabolism_Homo sapiens_hsa008301.59563250
32Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.57768644
33Drug metabolism - other enzymes_Homo sapiens_hsa009831.56863191
34Sulfur metabolism_Homo sapiens_hsa009201.56272668
35Phenylalanine metabolism_Homo sapiens_hsa003601.54118686
36Steroid biosynthesis_Homo sapiens_hsa001001.53466440
37Pyruvate metabolism_Homo sapiens_hsa006201.52746525
38Staphylococcus aureus infection_Homo sapiens_hsa051501.52260083
39Bile secretion_Homo sapiens_hsa049761.46296777
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.43636802
41Selenocompound metabolism_Homo sapiens_hsa004501.42379903
42Cysteine and methionine metabolism_Homo sapiens_hsa002701.25765723
43* Tyrosine metabolism_Homo sapiens_hsa003501.24417228
44Folate biosynthesis_Homo sapiens_hsa007901.22885547
45Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.22739209
46Proteasome_Homo sapiens_hsa030501.19820544
47Starch and sucrose metabolism_Homo sapiens_hsa005001.19471405
48Carbon metabolism_Homo sapiens_hsa012001.16798310
49Biosynthesis of amino acids_Homo sapiens_hsa012301.15810101
50Cyanoamino acid metabolism_Homo sapiens_hsa004601.12633331
51ABC transporters_Homo sapiens_hsa020101.10146145
52Arginine and proline metabolism_Homo sapiens_hsa003301.09267116
53Fat digestion and absorption_Homo sapiens_hsa049751.08814148
54Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.00236776
55Vitamin B6 metabolism_Homo sapiens_hsa007500.99754869
56Vitamin digestion and absorption_Homo sapiens_hsa049770.95979441
57Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.91787024
58Maturity onset diabetes of the young_Homo sapiens_hsa049500.88536035
59Sulfur relay system_Homo sapiens_hsa041220.86211466
60Glutathione metabolism_Homo sapiens_hsa004800.78442635
61Lysine degradation_Homo sapiens_hsa003100.76999336
62Glycerolipid metabolism_Homo sapiens_hsa005610.75958715
63Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.75650011
64Systemic lupus erythematosus_Homo sapiens_hsa053220.69500739
65Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.68455444
66Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.67709874
67Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.61567818
68Fatty acid biosynthesis_Homo sapiens_hsa000610.60917400
69Pyrimidine metabolism_Homo sapiens_hsa002400.60172752
70N-Glycan biosynthesis_Homo sapiens_hsa005100.59992155
71DNA replication_Homo sapiens_hsa030300.56330301
72Pentose phosphate pathway_Homo sapiens_hsa000300.53646077
73One carbon pool by folate_Homo sapiens_hsa006700.53588274
74* Metabolic pathways_Homo sapiens_hsa011000.50450138
75Mismatch repair_Homo sapiens_hsa034300.48154589
76Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.43771645
77Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.42510016
78Base excision repair_Homo sapiens_hsa034100.41381745
79Parkinsons disease_Homo sapiens_hsa050120.38695083
80alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.38452329
81Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.34369541
82Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.33896724
83Linoleic acid metabolism_Homo sapiens_hsa005910.33342451
84Platelet activation_Homo sapiens_hsa046110.32851543
85Prion diseases_Homo sapiens_hsa050200.28812929
86Pertussis_Homo sapiens_hsa051330.27643877
87SNARE interactions in vesicular transport_Homo sapiens_hsa041300.25408955
88Fructose and mannose metabolism_Homo sapiens_hsa000510.22910561
89Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.22320484
90Adipocytokine signaling pathway_Homo sapiens_hsa049200.21818963
91Nucleotide excision repair_Homo sapiens_hsa034200.21511482
92Glycerophospholipid metabolism_Homo sapiens_hsa005640.20355735
93Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.19860875
94Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.18729938
95RNA polymerase_Homo sapiens_hsa030200.17816797
96Insulin resistance_Homo sapiens_hsa049310.17576670
97Galactose metabolism_Homo sapiens_hsa000520.16720174
98Purine metabolism_Homo sapiens_hsa002300.15050072
99Hematopoietic cell lineage_Homo sapiens_hsa046400.10959203
100Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.08579438
101AMPK signaling pathway_Homo sapiens_hsa041520.03311040
102Glucagon signaling pathway_Homo sapiens_hsa049220.02897988
103Ether lipid metabolism_Homo sapiens_hsa005650.00390700
104Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.2257495
105Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.2195955
106Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.2122823
107African trypanosomiasis_Homo sapiens_hsa05143-0.1957371
108Hepatitis C_Homo sapiens_hsa05160-0.1872779
109Protein digestion and absorption_Homo sapiens_hsa04974-0.1763690
110Lysosome_Homo sapiens_hsa04142-0.1681782
111Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.1630287
112Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563-0.1605879
113Mineral absorption_Homo sapiens_hsa04978-0.1576458
114Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1562239
115Insulin signaling pathway_Homo sapiens_hsa04910-0.1524490
116Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1452796
117Oxidative phosphorylation_Homo sapiens_hsa00190-0.1367360
118Renin-angiotensin system_Homo sapiens_hsa04614-0.1352443
119Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1307932
120Regulation of autophagy_Homo sapiens_hsa04140-0.1091883
121Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0350418
122Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0333515

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