FAHD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 8.96737178
2signal complex assembly (GO:0007172)8.77868764
3positive regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043517)8.53871412
4maturation of 5.8S rRNA (GO:0000460)8.49893605
5regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 7.47698347
6regulation of mitochondrial translation (GO:0070129)7.39325781
7positive regulation of translational initiation (GO:0045948)7.37895580
8negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)7.37453894
9positive regulation of signal transduction by p53 class mediator (GO:1901798)6.73605420
10megakaryocyte development (GO:0035855)6.56693864
11erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.49661061
12L-phenylalanine catabolic process (GO:0006559)6.49661061
13erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.36053419
14L-phenylalanine metabolic process (GO:0006558)6.36053419
15cytochrome complex assembly (GO:0017004)6.28193606
16secretory granule organization (GO:0033363)6.23545610
17regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902253)6.10165934
18establishment of protein localization to mitochondrial membrane (GO:0090151)6.07819133
19pseudouridine synthesis (GO:0001522)6.04707591
20lysine metabolic process (GO:0006553)5.82642627
21lysine catabolic process (GO:0006554)5.82642627
22glyoxylate metabolic process (GO:0046487)5.79229083
23aromatic amino acid family catabolic process (GO:0009074)5.75939227
24cysteine metabolic process (GO:0006534)5.56502367
25protein complex biogenesis (GO:0070271)5.35605635
26triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.31009595
27indolalkylamine catabolic process (GO:0046218)5.16908626
28tryptophan catabolic process (GO:0006569)5.16908626
29indole-containing compound catabolic process (GO:0042436)5.16908626
30mitochondrial respiratory chain complex assembly (GO:0033108)5.12219262
31kynurenine metabolic process (GO:0070189)5.04331465
32cellular ketone body metabolic process (GO:0046950)4.91847837
33short-chain fatty acid metabolic process (GO:0046459)4.89148966
34tryptophan metabolic process (GO:0006568)4.86957341
35bile acid biosynthetic process (GO:0006699)4.84191243
36sulfur amino acid catabolic process (GO:0000098)4.83495400
37fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.78671520
38negative regulation of signal transduction by p53 class mediator (GO:1901797)4.70617130
39drug transmembrane transport (GO:0006855)4.66291884
40amino-acid betaine metabolic process (GO:0006577)4.63435110
41aspartate family amino acid catabolic process (GO:0009068)4.59518553
42serine family amino acid catabolic process (GO:0009071)4.56548271
43homocysteine metabolic process (GO:0050667)4.51510648
44platelet formation (GO:0030220)4.50276248
45ribosomal small subunit biogenesis (GO:0042274)4.48252936
46alpha-linolenic acid metabolic process (GO:0036109)4.46725168
47glutamate metabolic process (GO:0006536)4.34117416
48alpha-amino acid catabolic process (GO:1901606)4.33708862
49piRNA metabolic process (GO:0034587)4.29128628
50cellular modified amino acid catabolic process (GO:0042219)4.28445443
51fatty acid beta-oxidation (GO:0006635)4.26307281
52high-density lipoprotein particle remodeling (GO:0034375)4.26235306
532-oxoglutarate metabolic process (GO:0006103)4.26066439
54ketone body metabolic process (GO:1902224)4.25004189
55fusion of sperm to egg plasma membrane (GO:0007342)4.20949982
56ubiquinone biosynthetic process (GO:0006744)4.20901896
57aromatic amino acid family metabolic process (GO:0009072)4.19211050
58regulation of triglyceride catabolic process (GO:0010896)4.15740238
59complement activation, alternative pathway (GO:0006957)4.14827813
60urea cycle (GO:0000050)4.14649581
61urea metabolic process (GO:0019627)4.14649581
62regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043516)4.13825762
63cellular amino acid catabolic process (GO:0009063)4.12004470
64regulation of cholesterol esterification (GO:0010872)4.11355171
65ethanol oxidation (GO:0006069)4.10444743
66negative regulation of translational initiation (GO:0045947)4.10442384
67bile acid metabolic process (GO:0008206)4.08805932
68urate metabolic process (GO:0046415)4.05304294
69fatty acid oxidation (GO:0019395)4.05067625
70drug catabolic process (GO:0042737)4.00837527
71lipid oxidation (GO:0034440)4.00588819
72acetyl-CoA metabolic process (GO:0006084)3.98669631
73carnitine metabolic process (GO:0009437)3.98532873
74fatty acid catabolic process (GO:0009062)3.97611517
75respiratory chain complex IV assembly (GO:0008535)3.97600355
76coenzyme catabolic process (GO:0009109)3.95622768
77ubiquinone metabolic process (GO:0006743)3.91933950
78monocarboxylic acid catabolic process (GO:0072329)3.90235941
79protein-lipid complex remodeling (GO:0034368)3.90221172
80macromolecular complex remodeling (GO:0034367)3.90221172
81plasma lipoprotein particle remodeling (GO:0034369)3.90221172
82serine family amino acid metabolic process (GO:0009069)3.90158854
83regulation of protein activation cascade (GO:2000257)3.88934884
84drug transport (GO:0015893)3.88550413
85nitrogen cycle metabolic process (GO:0071941)3.86463175
86negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage (GO:1902230)3.85297537
87peptidyl-glutamic acid carboxylation (GO:0017187)3.82031373
88protein carboxylation (GO:0018214)3.82031373
89pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.82003011
90organic acid catabolic process (GO:0016054)3.81155030
91carboxylic acid catabolic process (GO:0046395)3.81155030
92negative regulation of fibrinolysis (GO:0051918)3.79503607
93viral transcription (GO:0019083)3.78196894
94reverse cholesterol transport (GO:0043691)3.77536206
95negative regulation of cholesterol transport (GO:0032375)3.76851146
96negative regulation of sterol transport (GO:0032372)3.76851146
97cellular glucuronidation (GO:0052695)3.75898309
98quinone biosynthetic process (GO:1901663)3.75717947
99aldehyde catabolic process (GO:0046185)3.75418268
100tyrosine metabolic process (GO:0006570)3.72116183
101acylglycerol homeostasis (GO:0055090)3.70455939
102triglyceride homeostasis (GO:0070328)3.70455939
103regulation of fibrinolysis (GO:0051917)3.67088687
104regulation of complement activation (GO:0030449)3.67065260
105translational termination (GO:0006415)3.66645513
106indolalkylamine metabolic process (GO:0006586)3.65225019
107flavonoid metabolic process (GO:0009812)3.63555776
108succinate metabolic process (GO:0006105)3.61705768
109cellular biogenic amine catabolic process (GO:0042402)3.60182143
110amine catabolic process (GO:0009310)3.60182143
111phospholipid efflux (GO:0033700)3.59900532
112branched-chain amino acid catabolic process (GO:0009083)3.58328813
113response to mercury ion (GO:0046689)3.58258259
114serine family amino acid biosynthetic process (GO:0009070)3.56643936
115dicarboxylic acid biosynthetic process (GO:0043650)3.53769573
116ribosomal small subunit assembly (GO:0000028)3.52709558
117tricarboxylic acid cycle (GO:0006099)3.52093862
118bile acid and bile salt transport (GO:0015721)3.51858969
119benzene-containing compound metabolic process (GO:0042537)3.51167318
120dicarboxylic acid metabolic process (GO:0043648)3.47375291
121glycine metabolic process (GO:0006544)3.45879276
122plasma membrane fusion (GO:0045026)3.45720419
123exogenous drug catabolic process (GO:0042738)3.44176263
124branched-chain amino acid metabolic process (GO:0009081)3.43871311
125low-density lipoprotein particle remodeling (GO:0034374)3.43446283
126transcytosis (GO:0045056)3.41387434
127glucuronate metabolic process (GO:0019585)3.41219551
128uronic acid metabolic process (GO:0006063)3.41219551
129inner mitochondrial membrane organization (GO:0007007)3.39590486
130pyrimidine nucleoside catabolic process (GO:0046135)3.39500391
131tricarboxylic acid metabolic process (GO:0072350)3.39364605
132cofactor catabolic process (GO:0051187)3.36192747
133oxaloacetate metabolic process (GO:0006107)3.35171783
134NADH metabolic process (GO:0006734)3.34931555
135mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.33102286
136valine metabolic process (GO:0006573)3.32646762
137cotranslational protein targeting to membrane (GO:0006613)3.29967718
138SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.29626619
139response to food (GO:0032094)3.28395929
140protein targeting to ER (GO:0045047)3.22055225
141rRNA modification (GO:0000154)3.21448724
142positive regulation of macrophage differentiation (GO:0045651)3.21411384
143T cell apoptotic process (GO:0070231)3.20919858
144negative regulation of membrane potential (GO:0045837)3.17052724
145mitochondrial respiratory chain complex I assembly (GO:0032981)3.14710658
146NADH dehydrogenase complex assembly (GO:0010257)3.14710658
147mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.14710658
148behavioral response to nicotine (GO:0035095)3.08003059
149regulation of intrinsic apoptotic signaling pathway in response to DNA damage (GO:1902229)3.04671568
150protein-cofactor linkage (GO:0018065)3.04636458
151establishment of protein localization to endoplasmic reticulum (GO:0072599)3.03942750
152respiratory electron transport chain (GO:0022904)3.03389232
153electron transport chain (GO:0022900)3.02155352
154regulation of translation in response to stress (GO:0043555)3.02003876
155protein localization to endoplasmic reticulum (GO:0070972)3.01997456
156pyrimidine nucleotide catabolic process (GO:0006244)2.96510681
157translational elongation (GO:0006414)2.91345540
158ATP synthesis coupled proton transport (GO:0015986)2.88425100
159energy coupled proton transport, down electrochemical gradient (GO:0015985)2.88425100
160lymphocyte apoptotic process (GO:0070227)2.87343350
161intracellular protein transmembrane import (GO:0044743)2.82350896
162translational initiation (GO:0006413)2.81858999
163regulation of signal transduction by p53 class mediator (GO:1901796)2.76469884
164cellular protein complex disassembly (GO:0043624)2.76264265
165translation (GO:0006412)2.74156542
166tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.73477649
167RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.73477649
168nucleoside transmembrane transport (GO:1901642)2.72132274
169mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.72094059
170neural tube formation (GO:0001841)2.71884237
171negative regulation of telomere maintenance (GO:0032205)2.71257267
172cullin deneddylation (GO:0010388)2.70059347
173negative regulation of chemokine production (GO:0032682)2.69206237
174water-soluble vitamin biosynthetic process (GO:0042364)2.68729208
175protein insertion into membrane (GO:0051205)2.67887103
176regulation of epidermal growth factor-activated receptor activity (GO:0007176)2.67549550
177protein kinase B signaling (GO:0043491)2.66086895
178myeloid cell development (GO:0061515)2.64067777
179nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.63705767
180sequestering of actin monomers (GO:0042989)2.59512618
181viral life cycle (GO:0019058)2.58320327
182platelet dense granule organization (GO:0060155)2.57759745
183regulation of oxidative phosphorylation (GO:0002082)2.56161211
184quinone metabolic process (GO:1901661)2.54319973
185negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.52779596
186mitochondrion morphogenesis (GO:0070584)2.50520552
187positive regulation of mast cell activation involved in immune response (GO:0033008)2.49674279
188positive regulation of mast cell degranulation (GO:0043306)2.49674279
189positive regulation of translation (GO:0045727)2.49588395
190oligodendrocyte development (GO:0014003)2.48680059
191positive regulation of fat cell differentiation (GO:0045600)2.46004741
192protein deneddylation (GO:0000338)2.45054726
193signal peptide processing (GO:0006465)2.44284107
194cellular component biogenesis (GO:0044085)2.43939764
195regulation of translational initiation (GO:0006446)2.40728562
196DNA replication-dependent nucleosome assembly (GO:0006335)2.36971535
197DNA replication-dependent nucleosome organization (GO:0034723)2.36971535
198RNA localization (GO:0006403)11.4341450

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse7.47901510
2PPARA_22158963_ChIP-Seq_LIVER_Mouse6.53790384
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.27842842
4EGR1_23403033_ChIP-Seq_LIVER_Mouse5.91442334
5* LXR_22158963_ChIP-Seq_LIVER_Mouse5.56778509
6CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human4.78925019
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.66609989
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.51352115
9SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.61404162
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.42989008
11NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.33033987
12ZNF274_21170338_ChIP-Seq_K562_Hela3.10860984
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.98635357
14TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.90056535
15HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.64310930
16* ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.52186106
17* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.45564572
18NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.44467574
19MYC_18940864_ChIP-ChIP_HL60_Human2.13650402
20GABP_17652178_ChIP-ChIP_JURKAT_Human2.13099855
21ZFP57_27257070_Chip-Seq_ESCs_Mouse2.08935887
22SALL1_21062744_ChIP-ChIP_HESCs_Human2.04426933
23ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.8522784
24* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.98336893
25NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.93649734
26BMI1_23680149_ChIP-Seq_NPCS_Mouse1.92977603
27ETS1_20019798_ChIP-Seq_JURKAT_Human1.92249524
28GATA1_22025678_ChIP-Seq_K562_Human1.89186671
29TP53_16413492_ChIP-PET_HCT116_Human1.88337876
30CBX2_27304074_Chip-Seq_ESCs_Mouse1.84659001
31AR_21572438_ChIP-Seq_LNCaP_Human1.83953143
32PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.81756866
33* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.73227880
34EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.71761040
35GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.64418175
36MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.64246331
37SRY_22984422_ChIP-ChIP_TESTIS_Rat1.61429071
38ZNF263_19887448_ChIP-Seq_K562_Human1.60219112
39CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.59096583
40FLI1_27457419_Chip-Seq_LIVER_Mouse1.58934743
41CTBP2_25329375_ChIP-Seq_LNCAP_Human1.56818677
42EED_16625203_ChIP-ChIP_MESCs_Mouse1.56254360
43RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.53669644
44TP63_19390658_ChIP-ChIP_HaCaT_Human1.51562814
45YY1_21170310_ChIP-Seq_MESCs_Mouse1.49924514
46PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.48798505
47CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.44904641
48POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.42141687
49CLOCK_20551151_ChIP-Seq_293T_Human1.41933538
50PCGF2_27294783_Chip-Seq_NPCs_Mouse1.39558187
51* RNF2_27304074_Chip-Seq_NSC_Mouse1.38477779
52EZH2_27304074_Chip-Seq_ESCs_Mouse1.37558938
53FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.37107736
54HTT_18923047_ChIP-ChIP_STHdh_Human1.35951617
55STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.34230984
56PCGF2_27294783_Chip-Seq_ESCs_Mouse1.33569238
57HNF4A_19822575_ChIP-Seq_HepG2_Human1.33483106
58GBX2_23144817_ChIP-Seq_PC3_Human1.31143353
59FOXA2_19822575_ChIP-Seq_HepG2_Human1.28946822
60SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.28800772
61TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.25966810
62PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.24122320
63FOXA1_27270436_Chip-Seq_PROSTATE_Human1.22566422
64FOXA1_25329375_ChIP-Seq_VCAP_Human1.22566422
65CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22495429
66STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.19301916
67ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.15468299
68* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.14830410
69PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.14007243
70JARID2_20064375_ChIP-Seq_MESCs_Mouse1.12305517
71ER_23166858_ChIP-Seq_MCF-7_Human1.11661214
72* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.10785263
73ETV2_25802403_ChIP-Seq_MESCs_Mouse1.10242668
74SOX2_27498859_Chip-Seq_STOMACH_Mouse1.09891038
75CTBP1_25329375_ChIP-Seq_LNCAP_Human1.09021656
76EZH2_22144423_ChIP-Seq_EOC_Human1.08845724
77ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.08420675
78IGF1R_20145208_ChIP-Seq_DFB_Human1.07381218
79RARG_19884340_ChIP-ChIP_MEFs_Mouse1.05882403
80TDRD3_21172665_ChIP-Seq_MCF-7_Human1.04964836
81* ERA_21632823_ChIP-Seq_H3396_Human1.04172264
82SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.03932867
83GATA4_25053715_ChIP-Seq_YYC3_Human1.03607373
84CDX2_20551321_ChIP-Seq_CACO-2_Human1.02875149
85THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.02846853
86MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.02556144
87STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.01574750
88AUTS2_25519132_ChIP-Seq_293T-REX_Human1.01461608
89CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.00827660
90SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.00783902
91EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.00413392
92HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.00273711
93SRF_21415370_ChIP-Seq_HL-1_Mouse1.00255500
94JARID2_20075857_ChIP-Seq_MESCs_Mouse1.00205895
95SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.99675890
96RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.99453859
97RXRA_24833708_ChIP-Seq_LIVER_Mouse0.98554739
98SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.98247999
99GATA1_26923725_Chip-Seq_HPCs_Mouse0.97401025
100IRF1_19129219_ChIP-ChIP_H3396_Human0.94814913
101EZH2_27294783_Chip-Seq_ESCs_Mouse0.93513259
102VDR_23849224_ChIP-Seq_CD4+_Human0.93121167
103SOX2_16153702_ChIP-ChIP_HESCs_Human0.92794982
104EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.92776575
105SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.92754162
106RNF2_18974828_ChIP-Seq_MESCs_Mouse0.92649117
107EZH2_18974828_ChIP-Seq_MESCs_Mouse0.92649117
108MYC_19829295_ChIP-Seq_ESCs_Human0.92543227
109SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.92009750
110P300_19829295_ChIP-Seq_ESCs_Human0.91866271
111CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.90913365
112* MYC_18555785_ChIP-Seq_MESCs_Mouse0.90253935
113FOXH1_21741376_ChIP-Seq_ESCs_Human0.90214654
114SUZ12_27294783_Chip-Seq_NPCs_Mouse0.89990700
115STAT3_1855785_ChIP-Seq_MESCs_Mouse0.89222049
116RAD21_21589869_ChIP-Seq_MESCs_Mouse0.88491317
117BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.87580209
118KLF5_20875108_ChIP-Seq_MESCs_Mouse0.87477055
119KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.86711544
120RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.86295116
121AR_20517297_ChIP-Seq_VCAP_Human0.86073814
122CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.85923089
123SOX2_21211035_ChIP-Seq_LN229_Human0.85227517
124* MYC_18358816_ChIP-ChIP_MESCs_Mouse0.84881623
125NFE2_27457419_Chip-Seq_LIVER_Mouse0.84836829
126NANOG_16153702_ChIP-ChIP_HESCs_Human0.84276797
127NANOG_19829295_ChIP-Seq_ESCs_Human0.84213376
128SOX2_19829295_ChIP-Seq_ESCs_Human0.84213376
129SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.81562285
130AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.78789022
131SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.76798274
132BCAT_22108803_ChIP-Seq_LS180_Human0.75007820
133ESR1_15608294_ChIP-ChIP_MCF-7_Human0.71556864
134PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.71487356
135BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.69430114
136VDR_22108803_ChIP-Seq_LS180_Human0.69368491
137NRF2_20460467_ChIP-Seq_MEFs_Mouse0.68256477
138NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.68256477
139ELF1_17652178_ChIP-ChIP_JURKAT_Human0.68090366
140EGR1_19032775_ChIP-ChIP_M12_Human0.66986577
141TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.66444298
142SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.66321824
143PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.65461528
144RARA_24833708_ChIP-Seq_LIVER_Mouse0.64449275
145* PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.64284843
146TAF2_19829295_ChIP-Seq_ESCs_Human0.63583398
147NCOR_22424771_ChIP-Seq_293T_Human0.61154174
148GATA1_19941826_ChIP-Seq_K562_Human0.60732126
149E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.60631654
150ERG_20517297_ChIP-Seq_VCAP_Human0.60573214
151* LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.60572146
152SOX2_20726797_ChIP-Seq_SW620_Human0.59769760
153TBX20_22080862_ChIP-Seq_HEART_Mouse0.58686113
154TBX20_22328084_ChIP-Seq_HEART_Mouse0.58686113
155ESR1_20079471_ChIP-ChIP_T-47D_Human0.58496255
156MYC_19915707_ChIP-ChIP_AK7_Human0.57516543
157OCT4_20526341_ChIP-Seq_ESCs_Human0.56819394
158* GATA1_19941827_ChIP-Seq_MEL_Mouse0.54692815
159EP300_21415370_ChIP-Seq_HL-1_Mouse0.54657837
160* GATA2_19941826_ChIP-Seq_K562_Human0.54479677
161CEBPB_22108803_ChIP-Seq_LS180_Human0.53911675
162FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.52599778
163EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.52454775
164CBP_21632823_ChIP-Seq_H3396_Human0.51911755
165CDX2_19796622_ChIP-Seq_MESCs_Mouse0.50379788
166NANOG_20526341_ChIP-Seq_ESCs_Human0.50207348
167KAP1_22055183_ChIP-Seq_ESCs_Mouse0.49652675
168* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.49426373
169CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.49198909
170TET1_21451524_ChIP-Seq_MESCs_Mouse0.48528143
171ESR2_21235772_ChIP-Seq_MCF-7_Human0.48295643
172ESET_19884257_ChIP-Seq_ESCs_Mouse0.47408626
173GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.46803156
174GATA6_25053715_ChIP-Seq_YYC3_Human0.46614796
175* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.46458043
176RBPJ_22232070_ChIP-Seq_NCS_Mouse0.45434908
177P53_21459846_ChIP-Seq_SAOS-2_Human0.44130134
178SOX2_22085726_ChIP-Seq_NPCs_Mouse0.43933699
179RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.43871711
180* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.43252050
181GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.43116729
182SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.42981369
183RARB_24833708_ChIP-Seq_LIVER_Mouse0.42647475

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis7.52951921
2MP0002139_abnormal_hepatobiliary_system7.33299260
3MP0005085_abnormal_gallbladder_physiolo5.58533447
4MP0005365_abnormal_bile_salt5.02032427
5MP0008875_abnormal_xenobiotic_pharmacok4.53096324
6MP0003806_abnormal_nucleotide_metabolis4.14472080
7MP0003252_abnormal_bile_duct3.96228239
8MP0005332_abnormal_amino_acid3.25316384
9MP0003195_calcinosis3.09711937
10MP0010329_abnormal_lipoprotein_level2.89098964
11MP0000372_irregular_coat_pigmentation2.86148870
12MP0002938_white_spotting2.83147858
13MP0009840_abnormal_foam_cell2.79348396
14MP0006292_abnormal_olfactory_placode2.68911313
15MP0002277_abnormal_respiratory_mucosa2.58601724
16MP0001666_abnormal_nutrient_absorption2.57641149
17MP0005083_abnormal_biliary_tract2.40976283
18MP0004019_abnormal_vitamin_homeostasis2.37360835
19MP0009379_abnormal_foot_pigmentation2.28872227
20MP0003136_yellow_coat_color2.28686403
21MP0002837_dystrophic_cardiac_calcinosis2.27415805
22MP0004043_abnormal_pH_regulation2.22601126
23MP0004145_abnormal_muscle_electrophysio2.18939503
24MP0006036_abnormal_mitochondrial_physio2.07576569
25MP0001764_abnormal_homeostasis1.98060427
26MP0005410_abnormal_fertilization1.88394525
27MP0002118_abnormal_lipid_homeostasis1.86913784
28MP0005503_abnormal_tendon_morphology1.85541740
29MP0005319_abnormal_enzyme/_coenzyme1.81220083
30MP0002138_abnormal_hepatobiliary_system1.79471109
31MP0003191_abnormal_cellular_cholesterol1.79320123
32MP0009643_abnormal_urine_homeostasis1.76694909
33MP0000609_abnormal_liver_physiology1.74301413
34MP0004133_heterotaxia1.70451439
35MP0003283_abnormal_digestive_organ1.63837318
36MP0005584_abnormal_enzyme/coenzyme_acti1.63347063
37MP0005636_abnormal_mineral_homeostasis1.54919819
38MP0003186_abnormal_redox_activity1.53042800
39MP0003656_abnormal_erythrocyte_physiolo1.48129903
40MP0004147_increased_porphyrin_level1.45282027
41MP0009046_muscle_twitch1.41034998
42MP0002735_abnormal_chemical_nociception1.39233211
43MP0003011_delayed_dark_adaptation1.38577169
44MP0003646_muscle_fatigue1.38387082
45MP0006035_abnormal_mitochondrial_morpho1.35785864
46MP0002102_abnormal_ear_morphology1.34801665
47MP0006072_abnormal_retinal_apoptosis1.34295588
48MP0000534_abnormal_ureter_morphology1.34098948
49MP0003868_abnormal_feces_composition1.33464874
50MP0003315_abnormal_perineum_morphology1.31609445
51MP0004142_abnormal_muscle_tone1.30898019
52MP0000462_abnormal_digestive_system1.30435229
53MP0005551_abnormal_eye_electrophysiolog1.28364077
54MP0000579_abnormal_nail_morphology1.26477032
55MP0004885_abnormal_endolymph1.26254061
56MP0002736_abnormal_nociception_after1.25974042
57MP0009250_abnormal_appendicular_skeleto1.25536092
58MP0005451_abnormal_body_composition1.24952252
59MP0002638_abnormal_pupillary_reflex1.24018624
60MP0001529_abnormal_vocalization1.20705136
61MP0000566_synostosis1.18119958
62MP0004215_abnormal_myocardial_fiber1.16651051
63MP0005645_abnormal_hypothalamus_physiol1.15947908
64MP0009697_abnormal_copulation1.15897798
65MP0002876_abnormal_thyroid_physiology1.13645461
66MP0005330_cardiomyopathy1.13439222
67MP0005187_abnormal_penis_morphology1.13063641
68MP0005253_abnormal_eye_physiology1.10113789
69MP0003880_abnormal_central_pattern1.07619293
70MP0009745_abnormal_behavioral_response1.06137716
71MP0010030_abnormal_orbit_morphology1.04133916
72MP0008058_abnormal_DNA_repair1.02860502
73MP0002557_abnormal_social/conspecific_i1.00918549
74MP0004130_abnormal_muscle_cell1.00621668
75MP0001765_abnormal_ion_homeostasis0.99018814
76MP0005266_abnormal_metabolism0.98716793
77MP0005376_homeostasis/metabolism_phenot0.98693037
78MP0001756_abnormal_urination0.93698037
79MP0000598_abnormal_liver_morphology0.93479278
80MP0002272_abnormal_nervous_system0.93391562
81MP0001664_abnormal_digestion0.92186162
82MP0005535_abnormal_body_temperature0.92116955
83MP0005646_abnormal_pituitary_gland0.92095182
84MP0001905_abnormal_dopamine_level0.91260241
85MP0002234_abnormal_pharynx_morphology0.91174815
86MP0002078_abnormal_glucose_homeostasis0.89854134
87MP0005084_abnormal_gallbladder_morpholo0.89816598
88MP0000631_abnormal_neuroendocrine_gland0.89596982
89MP0005386_behavior/neurological_phenoty0.89305223
90MP0004924_abnormal_behavior0.89305223
91MP0006276_abnormal_autonomic_nervous0.89156209
92MP0002282_abnormal_trachea_morphology0.86624169
93MP0001968_abnormal_touch/_nociception0.86321467
94MP0003300_gastrointestinal_ulcer0.86281473
95MP0001485_abnormal_pinna_reflex0.85064773
96MP0000230_abnormal_systemic_arterial0.84490425
97MP0009642_abnormal_blood_homeostasis0.84275422
98MP0002160_abnormal_reproductive_system0.82471593
99MP0000749_muscle_degeneration0.81348364
100MP0004036_abnormal_muscle_relaxation0.80253588
101MP0000751_myopathy0.79240783
102MP0003119_abnormal_digestive_system0.77305034
103MP0005670_abnormal_white_adipose0.76977065
104MP0005647_abnormal_sex_gland0.76567203
105MP0009764_decreased_sensitivity_to0.75781027
106MP0000049_abnormal_middle_ear0.75614901
107MP0005666_abnormal_adipose_tissue0.75107021
108MP0005389_reproductive_system_phenotype0.73928213
109MP0002971_abnormal_brown_adipose0.73851549
110MP0005197_abnormal_uvea_morphology0.73544117
111MP0002734_abnormal_mechanical_nocicepti0.73019107
112MP0002822_catalepsy0.72897847
113MP0003959_abnormal_lean_body0.72884766
114MP0002928_abnormal_bile_duct0.72186979
115MP0000604_amyloidosis0.72133756
116MP0002136_abnormal_kidney_physiology0.71547642
117MP0002733_abnormal_thermal_nociception0.71536167
118MP0001970_abnormal_pain_threshold0.71126837
119MP0005171_absent_coat_pigmentation0.70342399
120MP0001486_abnormal_startle_reflex0.69840178
121MP0002751_abnormal_autonomic_nervous0.69572171
122MP0008469_abnormal_protein_level0.69347289
123MP0009763_increased_sensitivity_to0.69206139
124MP0003718_maternal_effect0.68225779
125MP0003329_amyloid_beta_deposits0.67883643
126MP0001324_abnormal_eye_pigmentation0.66452441
127MP0004264_abnormal_extraembryonic_tissu0.65592431
128MP0005220_abnormal_exocrine_pancreas0.65213314
129MP0000026_abnormal_inner_ear0.65200870
130MP0005167_abnormal_blood-brain_barrier0.65109432
131MP0004084_abnormal_cardiac_muscle0.65002950
132MP0002972_abnormal_cardiac_muscle0.63707121
133MP0003137_abnormal_impulse_conducting0.62318931
134MP0009765_abnormal_xenobiotic_induced0.61297298
135MP0009384_cardiac_valve_regurgitation0.61232710
136MP0008775_abnormal_heart_ventricle0.57415713
137MP0006138_congestive_heart_failure0.56580440
138MP0005620_abnormal_muscle_contractility0.55644048
139MP0003221_abnormal_cardiomyocyte_apopto0.54738182
140MP0005334_abnormal_fat_pad0.54463624
141MP0001544_abnormal_cardiovascular_syste0.54177378
142MP0005385_cardiovascular_system_phenoty0.54177378
143MP0005377_hearing/vestibular/ear_phenot0.53516850
144MP0003878_abnormal_ear_physiology0.53516850
145MP0002254_reproductive_system_inflammat0.52990419
146MP0008872_abnormal_physiological_respon0.51993144
147MP0002269_muscular_atrophy0.51612013
148MP0005448_abnormal_energy_balance0.50772347
149MP0005408_hypopigmentation0.50741335
150MP0004087_abnormal_muscle_fiber0.50609895
151MP0005395_other_phenotype0.50092062
152MP0003953_abnormal_hormone_level0.49603866
153MP0003638_abnormal_response/metabolism_0.48363528
154MP0009780_abnormal_chondrocyte_physiolo0.47532322
155MP0003690_abnormal_glial_cell0.45283548
156MP0010630_abnormal_cardiac_muscle0.44675489
157MP0001661_extended_life_span0.43932255
158MP0002796_impaired_skin_barrier0.43870986
159MP0003705_abnormal_hypodermis_morpholog0.43840682
160MP0000747_muscle_weakness0.43518450
161MP0005165_increased_susceptibility_to0.43305276
162MP0004233_abnormal_muscle_weight0.42700735

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)5.57919402
2Cerebral hypomyelination (HP:0006808)5.26112136
3Intrahepatic cholestasis (HP:0001406)5.22438213
4Concave nail (HP:0001598)4.79487333
5Birth length less than 3rd percentile (HP:0003561)4.73901792
6Hyperglycinuria (HP:0003108)4.68930387
7Xanthomatosis (HP:0000991)4.68504926
8Hypobetalipoproteinemia (HP:0003563)4.63708133
9Deep venous thrombosis (HP:0002625)4.54927288
10Abnormality of monocarboxylic acid metabolism (HP:0010996)4.46200264
11Abnormality of glycine metabolism (HP:0010895)4.35134439
12Abnormality of serine family amino acid metabolism (HP:0010894)4.35134439
13Ketosis (HP:0001946)4.34887404
14Hyperammonemia (HP:0001987)4.34421873
15Abnormality of glutamine family amino acid metabolism (HP:0010902)4.31495340
16Hypoglycemic coma (HP:0001325)4.19581116
17Prolonged partial thromboplastin time (HP:0003645)4.18922087
18Abnormality of fatty-acid metabolism (HP:0004359)4.11259249
19Ketoacidosis (HP:0001993)3.94015431
20Abnormality of dicarboxylic acid metabolism (HP:0010995)3.92284074
21Dicarboxylic aciduria (HP:0003215)3.92284074
22Hyperglycinemia (HP:0002154)3.87045303
23Hyperlipoproteinemia (HP:0010980)3.82952927
24Abnormality of aspartate family amino acid metabolism (HP:0010899)3.78441694
25Hypolipoproteinemia (HP:0010981)3.60775450
26Hepatic necrosis (HP:0002605)3.59473352
27Abnormality of sulfur amino acid metabolism (HP:0004339)3.58382928
28Cerebral edema (HP:0002181)3.52852840
29Generalized aminoaciduria (HP:0002909)3.49699972
30Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.47254484
31Gout (HP:0001997)3.44927675
32Metabolic acidosis (HP:0001942)3.41442992
33Lethargy (HP:0001254)3.29540624
34Breast hypoplasia (HP:0003187)3.26897706
35Acute encephalopathy (HP:0006846)3.26419826
36Premature ovarian failure (HP:0008209)3.25262489
37Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.17745371
38Abnormality of methionine metabolism (HP:0010901)3.16074375
39Hypoalphalipoproteinemia (HP:0003233)3.15584178
40Glycosuria (HP:0003076)3.09707480
41Abnormality of urine glucose concentration (HP:0011016)3.09707480
42Delayed CNS myelination (HP:0002188)3.09190063
43Fat malabsorption (HP:0002630)3.07169200
44Hepatocellular necrosis (HP:0001404)3.06844533
45Abnormality of purine metabolism (HP:0004352)3.06083809
46Patellar aplasia (HP:0006443)3.04916088
47Hyperbilirubinemia (HP:0002904)3.03294716
48Proximal tubulopathy (HP:0000114)2.98177659
49Delusions (HP:0000746)2.97067788
50Aplasia/Hypoplasia of the patella (HP:0006498)2.96213712
51Pendular nystagmus (HP:0012043)2.94615163
52Complement deficiency (HP:0004431)2.91188698
53Epidermoid cyst (HP:0200040)2.91096202
54Increased hepatocellular lipid droplets (HP:0006565)2.89915505
55Hyperventilation (HP:0002883)2.84284312
56Microretrognathia (HP:0000308)2.81565102
57Abnormality of nucleobase metabolism (HP:0010932)2.80168779
58Joint hemorrhage (HP:0005261)2.79203401
59Vomiting (HP:0002013)2.78320466
60Keratoconus (HP:0000563)2.78218748
61Increased corneal curvature (HP:0100692)2.78218748
62CNS hypomyelination (HP:0003429)2.75656346
63Abnormal mitochondria in muscle tissue (HP:0008316)2.75540715
64Myoglobinuria (HP:0002913)2.74750306
65Agitation (HP:0000713)2.73934079
66Congenital stationary night blindness (HP:0007642)2.72827357
67Conjugated hyperbilirubinemia (HP:0002908)2.72600716
68Oral leukoplakia (HP:0002745)2.72010458
69Abnormality of the common coagulation pathway (HP:0010990)2.71760191
70Methylmalonic aciduria (HP:0012120)2.70766035
71Abnormality of serum amino acid levels (HP:0003112)2.68437930
72Acute necrotizing encephalopathy (HP:0006965)2.65257707
73Hydroxyprolinuria (HP:0003080)2.64333610
74Abnormality of proline metabolism (HP:0010907)2.64333610
75Testicular atrophy (HP:0000029)2.63759831
76Aplastic anemia (HP:0001915)2.61775149
77Aplasia/Hypoplasia involving the musculature (HP:0001460)2.60657957
78Increased purine levels (HP:0004368)2.59509165
79Hyperuricemia (HP:0002149)2.59509165
80Mitochondrial inheritance (HP:0001427)2.58865242
81Macrocytic anemia (HP:0001972)2.56979468
82Increased muscle lipid content (HP:0009058)2.56452602
83Unsteady gait (HP:0002317)2.55823060
84Prolonged neonatal jaundice (HP:0006579)2.55152287
85Lactic acidosis (HP:0003128)2.52837279
86Abnormality of the intrinsic pathway (HP:0010989)2.50794865
87Increased CSF lactate (HP:0002490)2.49006130
88Acanthocytosis (HP:0001927)2.48911024
89Secondary amenorrhea (HP:0000869)2.47759345
90Cholelithiasis (HP:0001081)2.47258288
91Abnormal number of erythroid precursors (HP:0012131)2.44747269
92Alkalosis (HP:0001948)2.44637743
93Late onset (HP:0003584)2.44480389
94Abnormal gallbladder morphology (HP:0012437)2.44292196
95Hypercholesterolemia (HP:0003124)2.43868552
96Short tibia (HP:0005736)2.42029247
97Abnormality of glycolysis (HP:0004366)2.41028436
98Increased serum pyruvate (HP:0003542)2.41028436
99Postnatal microcephaly (HP:0005484)2.39424287
100Renal Fanconi syndrome (HP:0001994)2.37794089
101Vascular calcification (HP:0004934)2.30722622
102Increased intramyocellular lipid droplets (HP:0012240)2.29766686
103Aplasia of the musculature (HP:0100854)2.29739791
104Hypoglycemic seizures (HP:0002173)2.28753122
105Abnormality of pyrimidine metabolism (HP:0004353)2.28338720
106Congenital, generalized hypertrichosis (HP:0004540)2.27574775
107Nausea (HP:0002018)2.27567855
108Type II lissencephaly (HP:0007260)2.26614376
109Cholecystitis (HP:0001082)2.26417750
110Abnormal gallbladder physiology (HP:0012438)2.26417750
111Severe muscular hypotonia (HP:0006829)2.26394289
112Aplasia/Hypoplasia of the tibia (HP:0005772)2.25537714
113Malnutrition (HP:0004395)2.25023632
114Adrenal hypoplasia (HP:0000835)2.23740453
115True hermaphroditism (HP:0010459)2.23671982
116Hyperphosphaturia (HP:0003109)2.21885229
117Ragged-red muscle fibers (HP:0003200)2.21175007
118Lipid accumulation in hepatocytes (HP:0006561)2.21095462
119Hepatocellular carcinoma (HP:0001402)2.20605841
120Nephronophthisis (HP:0000090)2.20576680
121Neonatal onset (HP:0003623)2.18608202
122Rhabdomyolysis (HP:0003201)2.18357441
123Progressive macrocephaly (HP:0004481)2.16384543
124Abnormality of the renal cortex (HP:0011035)2.16193570
125Poikilocytosis (HP:0004447)2.15488787
126Methylmalonic acidemia (HP:0002912)2.15360453
127Pancreatic cysts (HP:0001737)2.14562925
128Abnormality of cells of the erythroid lineage (HP:0012130)2.13311562
129Palpitations (HP:0001962)2.13248688
130Hyperinsulinemic hypoglycemia (HP:0000825)2.12941658
131Molar tooth sign on MRI (HP:0002419)2.11889779
132Abnormality of midbrain morphology (HP:0002418)2.11889779
133Steatorrhea (HP:0002570)2.11851872
134Sensorimotor neuropathy (HP:0007141)2.09310819
135CNS demyelination (HP:0007305)2.06798235
136Abnormality of the phalanges of the 2nd finger (HP:0009541)2.04691303
137Absent phalangeal crease (HP:0006109)2.04240285
138Abnormality of vitamin metabolism (HP:0100508)2.02947344
139Cardiovascular calcification (HP:0011915)2.00843093
140Irritability (HP:0000737)2.00671175
141Exertional dyspnea (HP:0002875)2.00317255
142Pancreatic fibrosis (HP:0100732)2.00192051
143Aplasia/hypoplasia of the uterus (HP:0008684)1.98350411
144Renal cortical cysts (HP:0000803)1.98204539
145Conjunctival hamartoma (HP:0100780)1.97654137
146Pancreatitis (HP:0001733)1.97498608
147Poor speech (HP:0002465)1.96839320
148Genu varum (HP:0002970)1.95470956
149Ileus (HP:0002595)1.94047800
150Emotional lability (HP:0000712)1.92398734
151Increased serum lactate (HP:0002151)1.92384422
152Optic disc pallor (HP:0000543)1.90640832
153Abnormality of the renal medulla (HP:0100957)1.89289229
154Scotoma (HP:0000575)1.88956574
155Chorioretinal atrophy (HP:0000533)1.88433932
156Short femoral neck (HP:0100864)1.87250047
157Renal tubular dysfunction (HP:0000124)1.84016544
158Reticulocytopenia (HP:0001896)1.82720657
159Hypoplasia of the uterus (HP:0000013)1.82477049
160Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.81812556
161Abnormality of alanine metabolism (HP:0010916)1.81812556
162Hyperalaninemia (HP:0003348)1.81812556
163Large for gestational age (HP:0001520)1.79560325
164Rough bone trabeculation (HP:0100670)1.75198844
165Long nose (HP:0003189)1.74804464
166Abnormal finger flexion creases (HP:0006143)1.73989160
167Pallor (HP:0000980)1.71188010
168Blindness (HP:0000618)1.70543060
169Abnormal number of incisors (HP:0011064)1.70255548
170Pancytopenia (HP:0001876)1.69811826
171Abnormal respiratory epithelium morphology (HP:0012253)1.67128511

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.70700111
2PRKCI3.77009186
3STK38L3.49308618
4WNK43.26201513
5PIK3CA3.14941002
6NUAK12.84515186
7BMPR22.66830406
8LMTK22.62037828
9MAP3K72.40233917
10MST42.36674632
11MYLK2.30349388
12OBSCN2.30255516
13WNK32.28122209
14OXSR12.24019230
15MAPKAPK32.21814747
16PKN22.19448376
17BMPR1B2.18251546
18PDK42.18139754
19PDK32.18139754
20ACVR1B2.13229504
21ERN12.01500121
22RIPK111.5944281
23MST1R1.99875626
24INSRR1.90378537
25SIK11.86455534
26TRIB31.81899459
27FGFR41.79512978
28DMPK1.73477591
29CASK1.66094157
30DAPK31.59227676
31STK391.55993210
32FLT31.46811186
33PRKCE1.42106912
34STK161.41406023
35PINK11.40086695
36TEC1.37477242
37ADRBK21.37321499
38ERBB41.35202899
39MAP2K41.34893912
40MAP4K11.30547574
41MAP3K121.30520043
42VRK21.30285857
43PASK1.27379574
44PHKG21.23131312
45PHKG11.23131312
46RAF11.18968865
47TIE11.18880791
48PIK3CG1.18550491
49NEK11.18079961
50KDR1.17756162
51PNCK1.16439973
52MAP4K21.14866490
53PDK21.14268853
54MAPK111.12559750
55GRK11.12251409
56ABL21.12123036
57WEE11.11842992
58FRK1.08719967
59LIMK11.06119354
60MAPK121.03919520
61MAP2K21.02201822
62TGFBR11.00893143
63PRKAA20.99225113
64ILK0.98480844
65TSSK60.98044898
66GRK60.92919750
67NME10.92139939
68MAP2K60.91951114
69PDPK10.91018864
70TLK10.88902545
71TAOK30.88118114
72STK380.87715831
73MUSK0.87678462
74TTN0.85701403
75MAP2K30.81682973
76PRKCD0.78282346
77NME20.76089570
78MAP2K70.76032612
79CAMKK10.73787830
80PRKAA10.73299703
81PAK30.73028371
82EPHA40.72324196
83CAMK2G0.70960026
84MAP2K10.70502305
85MAP3K30.69340684
86EIF2AK30.68756364
87PTK60.67643327
88TESK20.67610184
89PRKACG0.67197763
90TRIM280.66517902
91PDK10.65260936
92VRK10.64061808
93MAP3K110.64036553
94IRAK30.63638595
95NEK60.61668469
96PRKG20.60957503
97YES10.60274661
98BUB10.59343615
99MAP3K40.57787553
100PRKCQ0.55392617
101PRKACB0.54682025
102JAK20.54564436
103MAPK40.51627289
104EPHB20.51419516
105MET0.50541777
106SGK2230.48952611
107SGK4940.48952611
108PTK2B0.48817070
109TNIK0.47483032
110PRKACA0.47177638
111GRK70.46889708
112ROCK10.46559762
113MAPK130.46185760
114DAPK10.45283511
115CAMK2D0.44166763
116STK240.44141569
117PKN10.42885905
118CDK40.42832581
119DAPK20.41968382
120DYRK20.41681562
121ARAF0.41278314
122PLK30.40340875
123TBK10.39974636
124FGR0.39895313
125CSNK2A10.38805848
126TESK10.37105060
127TYK20.36928295
128CSNK1A10.34944144
129PRKCA0.34765000
130PLK40.34696855
131EPHA20.34605047
132CSNK2A20.34385399
133ERBB20.34125458
134PRKG10.34055984
135NEK20.33793107
136PLK10.32878451
137MAPK150.32576501
138PRKCB0.32341507
139RPS6KB10.31860520
140NTRK10.30895575
141CAMK2A0.29875329
142NTRK20.29826575
143CSNK1G30.29628218
144GSK3A0.29553704
145MAP3K50.28771728
146PIM20.28120659
147MARK10.27895928
148PRKCZ0.26732174
149NEK90.26533511
150PRKCG0.25906811
151PLK20.25004233
152ADRBK10.24944282
153SGK20.23963294
154RPS6KA50.23670503
155ZAK0.22800811
156MAPK70.22767087
157CSNK1G10.22735195
158CDK150.22564843
159CDK180.22422168

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030103.39140180
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.33345688
3Fatty acid degradation_Homo sapiens_hsa000712.91678603
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.90743456
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.89815736
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.87974618
7Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.82212265
8Propanoate metabolism_Homo sapiens_hsa006402.71537246
9Butanoate metabolism_Homo sapiens_hsa006502.67460260
10Nitrogen metabolism_Homo sapiens_hsa009102.57780752
11Tryptophan metabolism_Homo sapiens_hsa003802.47289934
122-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.45214505
13Arginine biosynthesis_Homo sapiens_hsa002202.39601397
14Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.37445320
15Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.35468040
16Pyruvate metabolism_Homo sapiens_hsa006202.28785826
17Peroxisome_Homo sapiens_hsa041462.19479098
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.18981044
19Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.14655721
20Fatty acid metabolism_Homo sapiens_hsa012122.10551285
21Pentose and glucuronate interconversions_Homo sapiens_hsa000402.07222347
22Carbon metabolism_Homo sapiens_hsa012001.83432105
23Sulfur metabolism_Homo sapiens_hsa009201.82296789
24Proteasome_Homo sapiens_hsa030501.82048423
25Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.73581453
26beta-Alanine metabolism_Homo sapiens_hsa004101.72296957
27Fatty acid elongation_Homo sapiens_hsa000621.71039502
28PPAR signaling pathway_Homo sapiens_hsa033201.70892681
29Complement and coagulation cascades_Homo sapiens_hsa046101.68512872
30Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.64154808
31Histidine metabolism_Homo sapiens_hsa003401.62721020
32Chemical carcinogenesis_Homo sapiens_hsa052041.50116002
33Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.48209511
34Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.47388049
35Phototransduction_Homo sapiens_hsa047441.46697675
36Bile secretion_Homo sapiens_hsa049761.46422835
37Starch and sucrose metabolism_Homo sapiens_hsa005001.43125005
38RNA degradation_Homo sapiens_hsa030181.40252481
39Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.38296532
40Oxidative phosphorylation_Homo sapiens_hsa001901.36567312
41Steroid hormone biosynthesis_Homo sapiens_hsa001401.35794857
42Retinol metabolism_Homo sapiens_hsa008301.34225645
43Biosynthesis of amino acids_Homo sapiens_hsa012301.33999954
44Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.33747278
45Selenocompound metabolism_Homo sapiens_hsa004501.33668650
46Cysteine and methionine metabolism_Homo sapiens_hsa002701.33115786
47Drug metabolism - other enzymes_Homo sapiens_hsa009831.32386380
48Phenylalanine metabolism_Homo sapiens_hsa003601.32318042
49Caffeine metabolism_Homo sapiens_hsa002321.27704797
50Cyanoamino acid metabolism_Homo sapiens_hsa004601.27101099
51Fat digestion and absorption_Homo sapiens_hsa049751.25039357
52Folate biosynthesis_Homo sapiens_hsa007901.24717293
53Arginine and proline metabolism_Homo sapiens_hsa003301.20328535
54Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.18682932
55RNA polymerase_Homo sapiens_hsa030201.15437042
56Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.14911951
57Parkinsons disease_Homo sapiens_hsa050121.14810848
58Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.13554920
59Regulation of autophagy_Homo sapiens_hsa041401.13013756
60Vitamin digestion and absorption_Homo sapiens_hsa049771.10650556
61* Tyrosine metabolism_Homo sapiens_hsa003501.08139519
62Maturity onset diabetes of the young_Homo sapiens_hsa049501.07333828
63Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.05570598
64Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.03936879
65Steroid biosynthesis_Homo sapiens_hsa001000.93767766
66Glutathione metabolism_Homo sapiens_hsa004800.93568869
67Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.92264259
68ErbB signaling pathway_Homo sapiens_hsa040120.91803122
69ABC transporters_Homo sapiens_hsa020100.91072165
70TGF-beta signaling pathway_Homo sapiens_hsa043500.90543313
71Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.90341939
72Staphylococcus aureus infection_Homo sapiens_hsa051500.85391513
73Sulfur relay system_Homo sapiens_hsa041220.84282034
74Olfactory transduction_Homo sapiens_hsa047400.84278861
75Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.84238998
76Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.81690321
77Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.81674884
78Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.79656444
79Alzheimers disease_Homo sapiens_hsa050100.77460019
80Nicotine addiction_Homo sapiens_hsa050330.74942790
81* Metabolic pathways_Homo sapiens_hsa011000.71248537
82Glycerolipid metabolism_Homo sapiens_hsa005610.68533646
83Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.67020997
84Purine metabolism_Homo sapiens_hsa002300.66937457
85Lysine degradation_Homo sapiens_hsa003100.65867936
86Pentose phosphate pathway_Homo sapiens_hsa000300.65802279
87Galactose metabolism_Homo sapiens_hsa000520.65350165
88Fructose and mannose metabolism_Homo sapiens_hsa000510.64906985
89RNA transport_Homo sapiens_hsa030130.59155406
90Huntingtons disease_Homo sapiens_hsa050160.54549251
91Cardiac muscle contraction_Homo sapiens_hsa042600.53288372
92Tight junction_Homo sapiens_hsa045300.50685696
93DNA replication_Homo sapiens_hsa030300.46898601
94Base excision repair_Homo sapiens_hsa034100.45691427
95Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.43380855
96Homologous recombination_Homo sapiens_hsa034400.43120762
97Axon guidance_Homo sapiens_hsa043600.40451596
98Fatty acid biosynthesis_Homo sapiens_hsa000610.38124694
99Vitamin B6 metabolism_Homo sapiens_hsa007500.36391358
100Taste transduction_Homo sapiens_hsa047420.35901835
101One carbon pool by folate_Homo sapiens_hsa006700.27483909
102alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.26046114
103Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.23103741
104Renin-angiotensin system_Homo sapiens_hsa046140.20826610
105Linoleic acid metabolism_Homo sapiens_hsa005910.19986694
106Glucagon signaling pathway_Homo sapiens_hsa049220.17622186
107Insulin resistance_Homo sapiens_hsa049310.17052945
108Mineral absorption_Homo sapiens_hsa049780.16660087
109Adipocytokine signaling pathway_Homo sapiens_hsa049200.11674127
110Glycerophospholipid metabolism_Homo sapiens_hsa005640.09642380
111Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.09448800
112Arachidonic acid metabolism_Homo sapiens_hsa005900.06254119
113AMPK signaling pathway_Homo sapiens_hsa041520.05403267
114Collecting duct acid secretion_Homo sapiens_hsa049660.02184921
115Protein digestion and absorption_Homo sapiens_hsa049740.01743017
116Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1878935
117Pyrimidine metabolism_Homo sapiens_hsa00240-0.1735893
118Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563-0.1381198
119Circadian rhythm_Homo sapiens_hsa04710-0.1199520
120Insulin signaling pathway_Homo sapiens_hsa04910-0.0867478
121Thyroid hormone synthesis_Homo sapiens_hsa04918-0.0758861
122Prion diseases_Homo sapiens_hsa05020-0.0680264
123Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0151661
124Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.0065389
125Protein export_Homo sapiens_hsa03060-0.0027440

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