FAHD2B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1oxidative phosphorylation (GO:0006119)4.17258015
2mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.71846881
3mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.69095565
4ATP synthesis coupled proton transport (GO:0015986)3.65600322
5energy coupled proton transport, down electrochemical gradient (GO:0015985)3.65600322
6deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.62146736
7maturation of SSU-rRNA (GO:0030490)3.59785016
8ribosomal small subunit assembly (GO:0000028)3.54294475
9rRNA modification (GO:0000154)3.41728527
10chaperone-mediated protein transport (GO:0072321)3.41241506
11pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.38895976
12respiratory electron transport chain (GO:0022904)3.32070019
13proteasome assembly (GO:0043248)3.27896833
14electron transport chain (GO:0022900)3.23788787
15mitochondrial respiratory chain complex I assembly (GO:0032981)3.17137582
16NADH dehydrogenase complex assembly (GO:0010257)3.17137582
17mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.17137582
18cullin deneddylation (GO:0010388)3.16846606
19L-serine metabolic process (GO:0006563)3.15195869
20mitochondrial respiratory chain complex assembly (GO:0033108)3.14284912
21DNA strand elongation involved in DNA replication (GO:0006271)3.13152812
22telomere maintenance via semi-conservative replication (GO:0032201)3.12607773
23peptidyl-histidine modification (GO:0018202)3.12406288
24protein complex biogenesis (GO:0070271)3.10078743
25ribosomal small subunit biogenesis (GO:0042274)3.07139549
26respiratory chain complex IV assembly (GO:0008535)3.05972719
27chromatin remodeling at centromere (GO:0031055)3.02747719
28viral transcription (GO:0019083)2.98889973
29establishment of integrated proviral latency (GO:0075713)2.98831977
30peptidyl-arginine omega-N-methylation (GO:0035247)2.98125626
31DNA strand elongation (GO:0022616)2.96853698
32DNA ligation (GO:0006266)2.94590833
33ubiquinone biosynthetic process (GO:0006744)2.92887922
34spliceosomal snRNP assembly (GO:0000387)2.92834679
35pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.92393149
36translational termination (GO:0006415)2.92368651
37pyrimidine nucleotide catabolic process (GO:0006244)2.90784835
38rRNA methylation (GO:0031167)2.89792613
39protein targeting to mitochondrion (GO:0006626)2.87324421
40branched-chain amino acid catabolic process (GO:0009083)2.87302694
41protein neddylation (GO:0045116)2.86386287
42regulation of mitochondrial translation (GO:0070129)2.85469434
43DNA replication checkpoint (GO:0000076)2.84604509
44CENP-A containing nucleosome assembly (GO:0034080)2.83064521
45tRNA aminoacylation for protein translation (GO:0006418)2.78983820
46ubiquinone metabolic process (GO:0006743)2.78006602
47pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.76956198
48base-excision repair, AP site formation (GO:0006285)2.76846374
49amino acid activation (GO:0043038)2.75889467
50tRNA aminoacylation (GO:0043039)2.75889467
51metallo-sulfur cluster assembly (GO:0031163)2.75769636
52iron-sulfur cluster assembly (GO:0016226)2.75769636
53translational elongation (GO:0006414)2.75347648
54tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.75342853
55RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.75342853
56ATP biosynthetic process (GO:0006754)2.75033962
57protein deneddylation (GO:0000338)2.74540054
58aldehyde catabolic process (GO:0046185)2.74226743
59histone exchange (GO:0043486)2.73567518
60pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.72670323
61negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.72202408
62cellular component biogenesis (GO:0044085)2.71756459
63positive regulation of mitochondrial fission (GO:0090141)2.70624790
64SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.70492053
65histone arginine methylation (GO:0034969)2.70214778
66mitochondrial RNA metabolic process (GO:0000959)2.69579433
67peptidyl-arginine N-methylation (GO:0035246)2.69413843
68peptidyl-arginine methylation (GO:0018216)2.69413843
69deoxyribose phosphate biosynthetic process (GO:0046385)2.68500460
702-deoxyribonucleotide biosynthetic process (GO:0009265)2.68500460
71aerobic respiration (GO:0009060)2.68492012
72DNA double-strand break processing (GO:0000729)2.67891898
73cytochrome complex assembly (GO:0017004)2.67747626
74purine nucleoside triphosphate biosynthetic process (GO:0009145)2.67721969
75purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.67428954
76establishment of protein localization to mitochondrion (GO:0072655)2.66982021
77protein-cofactor linkage (GO:0018065)2.65774758
78establishment of mitochondrion localization (GO:0051654)2.64868880
79cotranslational protein targeting to membrane (GO:0006613)2.64717709
80pseudouridine synthesis (GO:0001522)2.63424981
81ribonucleoside triphosphate biosynthetic process (GO:0009201)2.62866111
82protein localization to mitochondrion (GO:0070585)2.59750852
83nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.59422630
84ribosomal large subunit biogenesis (GO:0042273)2.58056300
85protein targeting to ER (GO:0045047)2.57296825
86maturation of 5.8S rRNA (GO:0000460)2.56647887
87negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.56273714
88ribonucleoprotein complex biogenesis (GO:0022613)2.55419223
89nucleotide-excision repair, DNA gap filling (GO:0006297)2.55228934
90deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.55070503
91kinetochore assembly (GO:0051382)2.54840684
92exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.54392808
93nucleoside triphosphate biosynthetic process (GO:0009142)2.53998397
94deoxyribonucleotide catabolic process (GO:0009264)2.51935678
95translation (GO:0006412)2.51493879
96regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.51172975
97purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.50172396
98purine nucleoside monophosphate biosynthetic process (GO:0009127)2.50172396
99CTP biosynthetic process (GO:0006241)2.49559619
100CTP metabolic process (GO:0046036)2.49559619

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.96403243
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.77351807
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.68304099
4JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.56176839
5E2F7_22180533_ChIP-Seq_HELA_Human3.46492561
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.25055245
7HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.22716684
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.21112902
9GABP_17652178_ChIP-ChIP_JURKAT_Human3.19437213
10EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.07152231
11EST1_17652178_ChIP-ChIP_JURKAT_Human3.02323607
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.84719730
13MYC_18358816_ChIP-ChIP_MESCs_Mouse2.83495633
14THAP11_20581084_ChIP-Seq_MESCs_Mouse2.75740302
15HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.59021733
16CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.42307535
17XRN2_22483619_ChIP-Seq_HELA_Human2.33060986
18MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.28188491
19MYC_19030024_ChIP-ChIP_MESCs_Mouse2.27248234
20TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.25407475
21PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.22485991
22YY1_21170310_ChIP-Seq_MESCs_Mouse2.22423308
23MYC_19079543_ChIP-ChIP_MESCs_Mouse2.21821501
24ELF1_17652178_ChIP-ChIP_JURKAT_Human2.20085141
25SRF_21415370_ChIP-Seq_HL-1_Mouse2.17448453
26E2F4_17652178_ChIP-ChIP_JURKAT_Human2.13038845
27GABP_19822575_ChIP-Seq_HepG2_Human2.12656681
28E2F1_18555785_ChIP-Seq_MESCs_Mouse2.04646387
29NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.01439595
30ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.99706018
31FOXP3_21729870_ChIP-Seq_TREG_Human1.98681202
32VDR_23849224_ChIP-Seq_CD4+_Human1.97020699
33MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.93414510
34EZH2_22144423_ChIP-Seq_EOC_Human1.85788532
35TTF2_22483619_ChIP-Seq_HELA_Human1.82570229
36CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.81224303
37DCP1A_22483619_ChIP-Seq_HELA_Human1.78404084
38PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.74262233
39NELFA_20434984_ChIP-Seq_ESCs_Mouse1.66712894
40YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.65894953
41CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.62693215
42MYC_18940864_ChIP-ChIP_HL60_Human1.60944241
43ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.57787086
44POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.57626714
45FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.50280383
46POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.49602574
47FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.49218807
48CIITA_25753668_ChIP-Seq_RAJI_Human1.44332875
49BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.39623920
50KDM5A_27292631_Chip-Seq_BREAST_Human1.34653817
51DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.33251831
52ZFX_18555785_ChIP-Seq_MESCs_Mouse1.32956204
53E2F1_21310950_ChIP-Seq_MCF-7_Human1.30163730
54MYCN_18555785_ChIP-Seq_MESCs_Mouse1.28986634
55SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.28958619
56MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.28812732
57ELK1_19687146_ChIP-ChIP_HELA_Human1.28077449
58SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.26159611
59* FOXP1_21924763_ChIP-Seq_HESCs_Human1.24967209
60CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.23669240
61CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.20326536
62SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.18822418
63ELF1_20517297_ChIP-Seq_JURKAT_Human1.14591454
64NANOG_18555785_ChIP-Seq_MESCs_Mouse1.14249710
65HOXB4_20404135_ChIP-ChIP_EML_Mouse1.13036409
66CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.10208074
67SRY_22984422_ChIP-ChIP_TESTIS_Rat1.09273573
68CTCF_18555785_ChIP-Seq_MESCs_Mouse1.05278424
69YY1_22570637_ChIP-Seq_MALME-3M_Human1.04799620
70E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.03947537
71KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.02754115
72TET1_21451524_ChIP-Seq_MESCs_Mouse1.02054789
73ZNF274_21170338_ChIP-Seq_K562_Hela1.01667650
74EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.97560950
75DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.95163338
76TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.92745952
77CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.91170320
78CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.90524463
79MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.89597128
80FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.88494632
81PADI4_21655091_ChIP-ChIP_MCF-7_Human0.88031756
82IGF1R_20145208_ChIP-Seq_DFB_Human0.87317244
83PHF8_20622854_ChIP-Seq_HELA_Human0.87024383
84P68_20966046_ChIP-Seq_HELA_Human0.86774239
85BCL6_27268052_Chip-Seq_Bcells_Human0.85768378
86TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.84030594
87RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.83926194
88E2F1_17053090_ChIP-ChIP_MCF-7_Human0.83842891
89TBX5_21415370_ChIP-Seq_HL-1_Mouse0.81536810
90REST_18959480_ChIP-ChIP_MESCs_Mouse0.81484697
91ERG_20887958_ChIP-Seq_HPC-7_Mouse0.81479805
92CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.81128786
93E2F1_20622854_ChIP-Seq_HELA_Human0.81127567
94PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.79929055
95FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.78969843
96SOX2_18555785_ChIP-Seq_MESCs_Mouse0.77049672
97FUS_26573619_Chip-Seq_HEK293_Human0.75408937
98ESR1_15608294_ChIP-ChIP_MCF-7_Human0.75024581
99SOX2_16153702_ChIP-ChIP_HESCs_Human0.74725529
100* ERA_21632823_ChIP-Seq_H3396_Human0.74159699

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode3.19150255
2MP0003880_abnormal_central_pattern2.94957643
3MP0008058_abnormal_DNA_repair2.70555747
4MP0010094_abnormal_chromosome_stability2.41400167
5MP0004147_increased_porphyrin_level2.38967295
6MP0002822_catalepsy2.37795564
7MP0004859_abnormal_synaptic_plasticity2.31876425
8MP0003693_abnormal_embryo_hatching2.22716947
9MP0001529_abnormal_vocalization2.10465828
10MP0006036_abnormal_mitochondrial_physio2.04058900
11MP0003111_abnormal_nucleus_morphology1.91737056
12MP0008877_abnormal_DNA_methylation1.84744648
13MP0005423_abnormal_somatic_nervous1.83060486
14MP0003136_yellow_coat_color1.78590438
15MP0005394_taste/olfaction_phenotype1.78416471
16MP0005499_abnormal_olfactory_system1.78416471
17MP0006276_abnormal_autonomic_nervous1.77912744
18MP0008932_abnormal_embryonic_tissue1.73636098
19MP0004957_abnormal_blastocyst_morpholog1.70330773
20MP0002234_abnormal_pharynx_morphology1.70252227
21MP0002938_white_spotting1.68988638
22MP0001293_anophthalmia1.67835098
23MP0003718_maternal_effect1.67495856
24MP0001968_abnormal_touch/_nociception1.66621230
25MP0008789_abnormal_olfactory_epithelium1.66490908
26MP0002736_abnormal_nociception_after1.65609702
27MP0001984_abnormal_olfaction1.64335483
28MP0003786_premature_aging1.64181465
29MP0006035_abnormal_mitochondrial_morpho1.59768481
30MP0005410_abnormal_fertilization1.59232847
31MP0003077_abnormal_cell_cycle1.53226782
32MP0000372_irregular_coat_pigmentation1.48707721
33MP0003787_abnormal_imprinting1.44720452
34MP0003122_maternal_imprinting1.42804103
35MP0003635_abnormal_synaptic_transmissio1.41414973
36MP0001905_abnormal_dopamine_level1.40869873
37MP0002272_abnormal_nervous_system1.38969161
38MP0008995_early_reproductive_senescence1.38526312
39MP0001929_abnormal_gametogenesis1.37971892
40MP0009046_muscle_twitch1.35473488
41MP0003698_abnormal_male_reproductive1.35097938
42MP0002735_abnormal_chemical_nociception1.34075829
43MP0009745_abnormal_behavioral_response1.32307752
44MP0005171_absent_coat_pigmentation1.30427467
45MP0004145_abnormal_muscle_electrophysio1.30249435
46MP0001486_abnormal_startle_reflex1.29508009
47MP0005646_abnormal_pituitary_gland1.28231387
48MP0003137_abnormal_impulse_conducting1.25612820
49MP0005645_abnormal_hypothalamus_physiol1.25140629
50MP0010030_abnormal_orbit_morphology1.22783399
51MP0009697_abnormal_copulation1.22431037
52MP0005253_abnormal_eye_physiology1.22179843
53MP0002210_abnormal_sex_determination1.21475738
54MP0006072_abnormal_retinal_apoptosis1.21181768
55MP0003186_abnormal_redox_activity1.20210317
56MP0003121_genomic_imprinting1.18608500
57MP0003123_paternal_imprinting1.17515085
58MP0002653_abnormal_ependyma_morphology1.17163130
59MP0000049_abnormal_middle_ear1.12355707
60MP0002063_abnormal_learning/memory/cond1.12289267
61MP0002064_seizures1.10817326
62MP0001764_abnormal_homeostasis1.10548756
63MP0001145_abnormal_male_reproductive1.09201538
64MP0000631_abnormal_neuroendocrine_gland1.09111162
65MP0003567_abnormal_fetal_cardiomyocyte1.09083671
66MP0002572_abnormal_emotion/affect_behav1.09073624
67MP0004133_heterotaxia1.08768585
68MP0002837_dystrophic_cardiac_calcinosis1.04881716
69MP0002160_abnormal_reproductive_system1.04369710
70MP0000653_abnormal_sex_gland1.03947656
71MP0000778_abnormal_nervous_system1.03352093
72MP0002638_abnormal_pupillary_reflex1.00931097
73MP0004270_analgesia0.99903272
74MP0002557_abnormal_social/conspecific_i0.99018643
75MP0005075_abnormal_melanosome_morpholog0.98708623
76MP0005551_abnormal_eye_electrophysiolog0.98579038
77MP0000955_abnormal_spinal_cord0.97281256
78MP0008875_abnormal_xenobiotic_pharmacok0.96465288
79MP0008007_abnormal_cellular_replicative0.96052799
80MP0001188_hyperpigmentation0.95287533
81MP0004811_abnormal_neuron_physiology0.92246545
82MP0003646_muscle_fatigue0.92070466
83MP0002102_abnormal_ear_morphology0.91316978
84MP0002249_abnormal_larynx_morphology0.88240880
85MP0002734_abnormal_mechanical_nocicepti0.87654263
86MP0002161_abnormal_fertility/fecundity0.87443789
87MP0000566_synostosis0.87086857
88MP0000751_myopathy0.85856552
89MP0002067_abnormal_sensory_capabilities0.85566817
90MP0001963_abnormal_hearing_physiology0.84293537
91MP0001970_abnormal_pain_threshold0.83768631
92MP0002733_abnormal_thermal_nociception0.81512480
93MP0000358_abnormal_cell_content/0.81117724
94MP0005377_hearing/vestibular/ear_phenot0.80158303
95MP0003878_abnormal_ear_physiology0.80158303
96MP0003806_abnormal_nucleotide_metabolis0.77924842
97MP0000678_abnormal_parathyroid_gland0.77610370
98MP0000749_muscle_degeneration0.76981605
99MP0008872_abnormal_physiological_respon0.76968903
100MP0003119_abnormal_digestive_system0.76797047

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)3.91999714
2Abnormal mitochondria in muscle tissue (HP:0008316)3.89919530
3Acute encephalopathy (HP:0006846)3.86775546
4Hepatocellular necrosis (HP:0001404)3.68981905
5Hepatic necrosis (HP:0002605)3.68492455
6Hyperglycinemia (HP:0002154)3.65358872
7Microvesicular hepatic steatosis (HP:0001414)3.56814255
8Mitochondrial inheritance (HP:0001427)3.56360997
9Increased serum pyruvate (HP:0003542)3.29180930
10Abnormality of glycolysis (HP:0004366)3.24274453
11Colon cancer (HP:0003003)3.21680281
12Increased CSF lactate (HP:0002490)3.20891769
13Progressive macrocephaly (HP:0004481)3.16022659
14Cerebral edema (HP:0002181)2.98130802
15Lactic acidosis (HP:0003128)2.93366056
16Myokymia (HP:0002411)2.87306270
17Reticulocytopenia (HP:0001896)2.75171779
18Increased serum lactate (HP:0002151)2.69601417
19Exercise intolerance (HP:0003546)2.67760057
20Cerebral hypomyelination (HP:0006808)2.54355264
21Abnormal number of erythroid precursors (HP:0012131)2.47162234
22Hyperglycinuria (HP:0003108)2.46121298
23Abnormality of the labia minora (HP:0012880)2.45877434
24Exercise-induced muscle cramps (HP:0003710)2.44479672
253-Methylglutaconic aciduria (HP:0003535)2.41834205
26Myoglobinuria (HP:0002913)2.41403546
27Abnormality of glycine metabolism (HP:0010895)2.41252481
28Abnormality of serine family amino acid metabolism (HP:0010894)2.41252481
29Abnormality of cells of the erythroid lineage (HP:0012130)2.39325616
30Decreased activity of mitochondrial respiratory chain (HP:0008972)2.33847182
31Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.33847182
32Increased intramyocellular lipid droplets (HP:0012240)2.28645866
33Tubulointerstitial nephritis (HP:0001970)2.19110654
34Respiratory failure (HP:0002878)2.18714741
35Abnormality of dicarboxylic acid metabolism (HP:0010995)2.16616461
36Dicarboxylic aciduria (HP:0003215)2.16616461
37Ragged-red muscle fibers (HP:0003200)2.13328967
38Progressive muscle weakness (HP:0003323)2.12875880
39Emotional lability (HP:0000712)2.08230958
40Abnormality of serum amino acid levels (HP:0003112)2.07772714
41Optic disc pallor (HP:0000543)2.07639144
42Pancreatic fibrosis (HP:0100732)2.05186970
43Increased muscle lipid content (HP:0009058)2.01276370
44Increased hepatocellular lipid droplets (HP:0006565)2.00907855
45CNS hypomyelination (HP:0003429)1.98763355
46Lipid accumulation in hepatocytes (HP:0006561)1.98701187
47Lethargy (HP:0001254)1.98157751
48Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.97387781
49Abnormality of alanine metabolism (HP:0010916)1.97387781
50Hyperalaninemia (HP:0003348)1.97387781
51Rhabdomyolysis (HP:0003201)1.97094424
52Hyperammonemia (HP:0001987)1.95530214
53Aplasia/Hypoplasia of the sacrum (HP:0008517)1.94502327
54Leukodystrophy (HP:0002415)1.92664856
55Gout (HP:0001997)1.91743730
56Septo-optic dysplasia (HP:0100842)1.91341459
57Abnormality of the anterior horn cell (HP:0006802)1.89921237
58Degeneration of anterior horn cells (HP:0002398)1.89921237
59Progressive microcephaly (HP:0000253)1.85264168
60Sclerocornea (HP:0000647)1.83981750
61Gait imbalance (HP:0002141)1.83889404
62Nephrogenic diabetes insipidus (HP:0009806)1.83544484
63Methylmalonic acidemia (HP:0002912)1.82833764
64Methylmalonic aciduria (HP:0012120)1.82681683
65Medial flaring of the eyebrow (HP:0010747)1.80157972
66Macrocytic anemia (HP:0001972)1.79206992
67Double outlet right ventricle (HP:0001719)1.78868926
68Congenital malformation of the right heart (HP:0011723)1.78868926
69Congenital primary aphakia (HP:0007707)1.78722935
70Renal Fanconi syndrome (HP:0001994)1.77380171
71CNS demyelination (HP:0007305)1.76068807
72Meckel diverticulum (HP:0002245)1.74128339
73Focal motor seizures (HP:0011153)1.71591191
74Broad distal phalanx of finger (HP:0009836)1.69237339
75Abnormality of the ileum (HP:0001549)1.68639928
76Abnormality of the parathyroid morphology (HP:0011766)1.64563029
77Opisthotonus (HP:0002179)1.63907055
78Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.62303683
79Retinal dysplasia (HP:0007973)1.62046113
80Neoplasm of the adrenal gland (HP:0100631)1.61883069
81Type I transferrin isoform profile (HP:0003642)1.61725696
82Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.61574226
83Abnormal protein N-linked glycosylation (HP:0012347)1.61574226
84Abnormal protein glycosylation (HP:0012346)1.61574226
85Abnormal glycosylation (HP:0012345)1.61574226
86Muscle fiber atrophy (HP:0100295)1.61484319
87Abnormality of reticulocytes (HP:0004312)1.61235238
88Abnormality of the metopic suture (HP:0005556)1.60092637
89Hypoglycemic coma (HP:0001325)1.58364345
90Delusions (HP:0000746)1.58150052
91Generalized aminoaciduria (HP:0002909)1.56956161
92Postaxial foot polydactyly (HP:0001830)1.56357859
93Type 2 muscle fiber atrophy (HP:0003554)1.56022181
94Polyphagia (HP:0002591)1.55228819
95Severe visual impairment (HP:0001141)1.54773420
96Hypoplastic pelvis (HP:0008839)1.54678672
97Aplasia/Hypoplasia of the uvula (HP:0010293)1.53108222
98Sloping forehead (HP:0000340)1.52388247
99Triphalangeal thumb (HP:0001199)1.52079405
100Abnormal gallbladder physiology (HP:0012438)1.51629258

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK4.15240918
2BUB13.62680460
3VRK23.21382321
4MAP4K22.99024501
5NME22.85477925
6CDC72.51875724
7SRPK12.51683707
8CDK192.47403606
9PLK42.37777361
10ZAK2.34021921
11STK162.17426938
12NEK12.15714954
13EPHA42.12761531
14TRIM281.92607232
15MAP2K71.88018212
16NME11.84010269
17MAP3K41.81470690
18DYRK21.71772729
19PBK1.70563383
20MKNK11.65357100
21TESK21.64560335
22TTK1.62993455
23VRK11.57657119
24CSNK1G31.56204279
25NUAK11.54361476
26PRKD31.54122565
27PDK21.35811014
28PLK31.34150769
29PLK11.32056323
30CSNK1G21.31111374
31ATR1.30760081
32MAPKAPK51.29619476
33PLK21.28906703
34DAPK11.27709996
35CSNK1A1L1.20072547
36PAK61.17934935
37TESK11.17042119
38CSNK1G11.16820487
39PHKG21.12504363
40PHKG11.12504363
41OBSCN1.12375094
42PINK11.10217642
43BRSK11.09420718
44PIM21.04854694
45WNK31.02526305
46MARK10.99920790
47AURKA0.97979874
48ARAF0.96829104
49TIE10.95205487
50MINK10.90337441
51CHEK20.87906566
52CCNB10.81648504
53UHMK10.81588773
54KDR0.80235991
55CDK11A0.78899701
56BCR0.78207128
57CDK140.76471723
58WEE10.75777071
59PRKCG0.71779259
60EIF2AK10.70752414
61CDK180.70305841
62LIMK10.70111248
63MAP3K110.69424417
64CDK150.69044530
65AURKB0.67889646
66ABL20.66877477
67CDK70.65391060
68ATM0.64098386
69RPS6KA50.63348711
70MAPK130.62833515
71CHEK10.62643810
72MAP2K40.61104535
73BRAF0.59333915
74CSNK2A20.58873373
75GRK50.57223207
76CDK20.56895881
77TSSK60.56861769
78DYRK30.56206821
79CAMK2A0.54346435
80CSNK2A10.53747004
81NTRK30.52209532
82CDK10.48993704
83DAPK30.47910851
84TNIK0.46642681
85CAMK10.46238142
86PRKDC0.43962373
87FLT30.43692652
88PRKACB0.40630194
89CDK50.40479852
90WNK40.40171090
91DYRK1A0.39375255
92PASK0.39297869
93NTRK20.39163241
94CAMK2B0.39060506
95CSNK1E0.38693523
96CAMK2G0.37793478
97GRK10.37267998
98DYRK1B0.36375379
99RPS6KA40.36059349
100CSNK1A10.35823593

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.03330618
2Oxidative phosphorylation_Homo sapiens_hsa001902.98016648
3Ribosome_Homo sapiens_hsa030102.97741328
4Parkinsons disease_Homo sapiens_hsa050122.80512166
5Base excision repair_Homo sapiens_hsa034102.63233408
6Mismatch repair_Homo sapiens_hsa034302.62747899
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.48371795
8Proteasome_Homo sapiens_hsa030502.47081837
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.26136951
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.20096486
112-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.06326125
12Huntingtons disease_Homo sapiens_hsa050162.00019161
13Fatty acid elongation_Homo sapiens_hsa000621.99614007
14Fanconi anemia pathway_Homo sapiens_hsa034601.96805763
15Non-homologous end-joining_Homo sapiens_hsa034501.95232191
16Homologous recombination_Homo sapiens_hsa034401.93197857
17Biosynthesis of amino acids_Homo sapiens_hsa012301.90767607
18Sulfur relay system_Homo sapiens_hsa041221.87874283
19Propanoate metabolism_Homo sapiens_hsa006401.86400409
20RNA polymerase_Homo sapiens_hsa030201.85925626
21Nucleotide excision repair_Homo sapiens_hsa034201.83001766
22Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.80186982
23Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.75040816
24Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.74766203
25Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.72434273
26Cysteine and methionine metabolism_Homo sapiens_hsa002701.70435661
27Carbon metabolism_Homo sapiens_hsa012001.70248426
28Alzheimers disease_Homo sapiens_hsa050101.68258241
29Spliceosome_Homo sapiens_hsa030401.66587460
30Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.64052916
31Cardiac muscle contraction_Homo sapiens_hsa042601.57699566
32Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.57408920
33Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.51804317
34RNA transport_Homo sapiens_hsa030131.48305117
35Pyrimidine metabolism_Homo sapiens_hsa002401.45057875
36Pyruvate metabolism_Homo sapiens_hsa006201.44125197
37RNA degradation_Homo sapiens_hsa030181.42499104
38One carbon pool by folate_Homo sapiens_hsa006701.41786589
39Butanoate metabolism_Homo sapiens_hsa006501.30408601
40Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.24107859
41Protein export_Homo sapiens_hsa030601.21086998
42Arginine and proline metabolism_Homo sapiens_hsa003301.19066029
43Fatty acid metabolism_Homo sapiens_hsa012121.17367845
44Purine metabolism_Homo sapiens_hsa002301.14538952
45Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.12797993
46Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.11696639
47Nicotine addiction_Homo sapiens_hsa050331.09575038
48Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.01374396
49Basal transcription factors_Homo sapiens_hsa030220.99416606
50Peroxisome_Homo sapiens_hsa041460.97464065
51Cell cycle_Homo sapiens_hsa041100.97409912
52Glutathione metabolism_Homo sapiens_hsa004800.94885692
53Metabolic pathways_Homo sapiens_hsa011000.89857825
54Steroid biosynthesis_Homo sapiens_hsa001000.87320120
55Fatty acid degradation_Homo sapiens_hsa000710.87193774
56Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.86702812
57Oocyte meiosis_Homo sapiens_hsa041140.84303442
58Folate biosynthesis_Homo sapiens_hsa007900.83624245
59beta-Alanine metabolism_Homo sapiens_hsa004100.81784374
60Synaptic vesicle cycle_Homo sapiens_hsa047210.80693362
61Pentose phosphate pathway_Homo sapiens_hsa000300.80037415
62Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.76558393
63Selenocompound metabolism_Homo sapiens_hsa004500.72294065
64Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.71032133
65Cyanoamino acid metabolism_Homo sapiens_hsa004600.69757910
66Vitamin B6 metabolism_Homo sapiens_hsa007500.69525529
67Arginine biosynthesis_Homo sapiens_hsa002200.63978254
68Caffeine metabolism_Homo sapiens_hsa002320.62261277
69mRNA surveillance pathway_Homo sapiens_hsa030150.59800334
70Phenylalanine metabolism_Homo sapiens_hsa003600.59535841
71Phototransduction_Homo sapiens_hsa047440.58055206
72Tyrosine metabolism_Homo sapiens_hsa003500.50037384
73Nitrogen metabolism_Homo sapiens_hsa009100.48480817
74Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.46280355
75GABAergic synapse_Homo sapiens_hsa047270.46040364
76Olfactory transduction_Homo sapiens_hsa047400.45299330
77Collecting duct acid secretion_Homo sapiens_hsa049660.43794161
78Fructose and mannose metabolism_Homo sapiens_hsa000510.42299695
79Taste transduction_Homo sapiens_hsa047420.41943062
80Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.40182673
81Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.39560689
82Primary bile acid biosynthesis_Homo sapiens_hsa001200.32850194
83Tryptophan metabolism_Homo sapiens_hsa003800.30543188
84Linoleic acid metabolism_Homo sapiens_hsa005910.29261904
85N-Glycan biosynthesis_Homo sapiens_hsa005100.28756553
86Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.27869993
87Basal cell carcinoma_Homo sapiens_hsa052170.27395603
88Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.27330863
89Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.26782544
90Lysine degradation_Homo sapiens_hsa003100.25928861
91Morphine addiction_Homo sapiens_hsa050320.23925628
92Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.22760898
93Regulation of autophagy_Homo sapiens_hsa041400.20944838
94Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.20531281
95Galactose metabolism_Homo sapiens_hsa000520.18480019
96Glycerophospholipid metabolism_Homo sapiens_hsa005640.18349564
97Sulfur metabolism_Homo sapiens_hsa009200.17074233
98Circadian entrainment_Homo sapiens_hsa047130.16364628
99Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.16169972
100Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.15415406

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