ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	establishment of mitochondrion localization (GO:0051654)	4.69769031
2	central nervous system myelination (GO:0022010)	4.68776277
3	axon ensheathment in central nervous system (GO:0032291)	4.68776277
4	chaperone-mediated protein transport (GO:0072321)	4.07728051
5	establishment of mitochondrion localization, microtubule-mediated (GO:0034643)	4.04319579
6	mitochondrion transport along microtubule (GO:0047497)	4.04319579
7	postsynaptic membrane organization (GO:0001941)	3.95292604
8	behavioral response to nicotine (GO:0035095)	3.84677751
9	ribosomal small subunit assembly (GO:0000028)	3.68367971
10	protein complex biogenesis (GO:0070271)	3.64809515
11	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.64063721
12	regulation of cilium movement (GO:0003352)	3.59805604
13	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.56400940
14	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.54036115
15	NADH dehydrogenase complex assembly (GO:0010257)	3.54036115
16	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.54036115
17	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.52120427
18	neurotransmitter catabolic process (GO:0042135)	3.45267738
19	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.42240871
20	ATP synthesis coupled proton transport (GO:0015986)	3.42240871
21	respiratory chain complex IV assembly (GO:0008535)	3.37953323
22	presynaptic membrane organization (GO:0097090)	3.36766668
23	nonmotile primary cilium assembly (GO:0035058)	3.33772548
24	protein polyglutamylation (GO:0018095)	3.33523659
25	presynaptic membrane assembly (GO:0097105)	3.31599501
26	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.31358976
27	peptidyl-histidine modification (GO:0018202)	3.30099884
28	mitochondrial respiratory chain complex assembly (GO:0033108)	3.29176858
29	synaptic vesicle maturation (GO:0016188)	3.22823107
30	regulation of microtubule-based movement (GO:0060632)	3.21162901
31	cytochrome complex assembly (GO:0017004)	3.18411300
32	response to pheromone (GO:0019236)	3.17233397
33	respiratory electron transport chain (GO:0022904)	3.13549046
34	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	3.12639778
35	electron transport chain (GO:0022900)	3.09764443
36	DNA deamination (GO:0045006)	3.07351336
37	pyrimidine nucleotide catabolic process (GO:0006244)	3.07086553
38	pyrimidine nucleobase catabolic process (GO:0006208)	3.06581333
39	preassembly of GPI anchor in ER membrane (GO:0016254)	3.05135807
40	intraciliary transport (GO:0042073)	3.01276383
41	metallo-sulfur cluster assembly (GO:0031163)	3.00593434
42	iron-sulfur cluster assembly (GO:0016226)	3.00593434
43	neuronal action potential propagation (GO:0019227)	2.99623923
44	neuron cell-cell adhesion (GO:0007158)	2.96236975
45	rRNA modification (GO:0000154)	2.94135340
46	mannosylation (GO:0097502)	2.84941592
47	synaptic vesicle exocytosis (GO:0016079)	2.83542763
48	neuronal ion channel clustering (GO:0045161)	2.83143197
49	protein neddylation (GO:0045116)	2.82829691
50	oxidative phosphorylation (GO:0006119)	2.79912835
51	synaptic transmission, cholinergic (GO:0007271)	2.73351646
52	gamma-aminobutyric acid transport (GO:0015812)	2.73075907
53	vocalization behavior (GO:0071625)	2.71771747
54	tRNA modification (GO:0006400)	2.71612574
55	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.69831427
56	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.69831427
57	acrosome reaction (GO:0007340)	2.66964559
58	aldehyde catabolic process (GO:0046185)	2.66562229
59	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.64973201
60	epithelial cilium movement (GO:0003351)	2.64073881
61	auditory behavior (GO:0031223)	2.61843911
62	pseudouridine synthesis (GO:0001522)	2.61651626
63	neuromuscular synaptic transmission (GO:0007274)	2.59608885
64	negative regulation of response to food (GO:0032096)	2.58976657
65	negative regulation of appetite (GO:0032099)	2.58976657
66	viral transcription (GO:0019083)	2.58781976
67	photoreceptor cell maintenance (GO:0045494)	2.58319695
68	protein-cofactor linkage (GO:0018065)	2.57161484
69	protein localization to synapse (GO:0035418)	2.54877309
70	brain morphogenesis (GO:0048854)	2.54559992
71	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	2.54289394
72	neurotransmitter-gated ion channel clustering (GO:0072578)	2.53584676
73	base-excision repair, AP site formation (GO:0006285)	2.51767069
74	regulation of mitochondrial translation (GO:0070129)	2.51739313
75	response to gravity (GO:0009629)	2.50598831
76	translational termination (GO:0006415)	2.49529428
77	retinal cone cell development (GO:0046549)	2.49212745
78	GPI anchor metabolic process (GO:0006505)	2.48070844
79	intracellular protein transmembrane import (GO:0044743)	2.48034180
80	kynurenine metabolic process (GO:0070189)	2.47460015
81	inner mitochondrial membrane organization (GO:0007007)	2.44186139
82	GPI anchor biosynthetic process (GO:0006506)	2.44046873
83	seminiferous tubule development (GO:0072520)	2.43441552
84	amine catabolic process (GO:0009310)	2.43239838
85	cellular biogenic amine catabolic process (GO:0042402)	2.43239838
86	axoneme assembly (GO:0035082)	2.43163611
87	branched-chain amino acid catabolic process (GO:0009083)	2.42998256
88	hydrogen ion transmembrane transport (GO:1902600)	2.42186112
89	transmission of nerve impulse (GO:0019226)	2.40817222
90	mechanosensory behavior (GO:0007638)	2.40577305
91	ATP biosynthetic process (GO:0006754)	2.39597463
92	dicarboxylic acid catabolic process (GO:0043649)	2.39144047
93	nucleobase catabolic process (GO:0046113)	2.38409963
94	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.38224091
95	regulation of dopamine metabolic process (GO:0042053)	2.38212940
96	regulation of catecholamine metabolic process (GO:0042069)	2.38212940
97	proton transport (GO:0015992)	2.37319364
98	platelet dense granule organization (GO:0060155)	2.35885286
99	iron coordination entity transport (GO:1901678)	2.35662497
100	negative regulation of telomere maintenance (GO:0032205)	2.35635520

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.02562002
2	EZH2_22144423_ChIP-Seq_EOC_Human	3.97082239
3	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.27825164
4	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	3.19336255
5	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	3.10016523
6	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.92458051
7	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.80759850
8	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.71896339
9	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.61291917
10	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.28428567
11	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.28097132
12	ZNF274_21170338_ChIP-Seq_K562_Hela	2.19200756
13	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.04526224
14	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.01812400
15	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	2.01708407
16	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.99872655
17	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.98796210
18	REST_21632747_ChIP-Seq_MESCs_Mouse	1.84055106
19	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.82830434
20	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.80357868
21	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.76320674
22	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.76190260
23	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.71341538
24	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.69556247
25	IRF1_19129219_ChIP-ChIP_H3396_Human	1.62617111
26	VDR_23849224_ChIP-Seq_CD4+_Human	1.57296003
27	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.53449617
28	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.51658695
29	GABP_19822575_ChIP-Seq_HepG2_Human	1.48926624
30	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.44173369
31	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.43602706
32	FOXP3_21729870_ChIP-Seq_TREG_Human	1.43121062
33	MYC_18940864_ChIP-ChIP_HL60_Human	1.40344120
34	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.39767170
35	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.36875598
36	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.32341026
37	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.30450212
38	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.29775807
39	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.29218297
40	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.27022329
41	GBX2_23144817_ChIP-Seq_PC3_Human	1.26558512
42	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.25489720
43	IGF1R_20145208_ChIP-Seq_DFB_Human	1.23962262
44	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.23622237
45	ERA_21632823_ChIP-Seq_H3396_Human	1.23133466
46	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.22891630
47	TP53_22573176_ChIP-Seq_HFKS_Human	1.21515088
48	RNF2_27304074_Chip-Seq_NSC_Mouse	1.19263180
49	XRN2_22483619_ChIP-Seq_HELA_Human	1.17244605
50	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.17063036
51	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.16924746
52	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.16341732
53	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.16313623
54	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.15922940
55	FOXP1_21924763_ChIP-Seq_HESCs_Human	1.15897824
56	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.14671625
57	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.14441338
58	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.14036666
59	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.13662078
60	BCL6_27268052_Chip-Seq_Bcells_Human	1.13519671
61	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.13357536
62	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.12235695
63	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.11822107
64	MYC_19829295_ChIP-Seq_ESCs_Human	1.11156306
65	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	1.08390300
66	FUS_26573619_Chip-Seq_HEK293_Human	1.08382816
67	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.06737216
68	TAF2_19829295_ChIP-Seq_ESCs_Human	1.06358427
69	E2F1_20622854_ChIP-Seq_HELA_Human	1.06089898
70	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.03994356
71	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.03356122
72	CTCF_20526341_ChIP-Seq_ESCs_Human	1.02997488
73	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.02966522
74	JARID2_20064375_ChIP-Seq_MESCs_Mouse	0.99939729
75	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	0.99447779
76	PHF8_20622854_ChIP-Seq_HELA_Human	0.98799316
77	OCT4_19829295_ChIP-Seq_ESCs_Human	0.98641629
78	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.98132321
79	CTCF_18555785_ChIP-Seq_MESCs_Mouse	0.97645213
80	E2F1_18555785_ChIP-Seq_MESCs_Mouse	0.97438317
81	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.97179797
82	TTF2_22483619_ChIP-Seq_HELA_Human	0.96850176
83	P68_20966046_ChIP-Seq_HELA_Human	0.96565132
84	NANOG_20526341_ChIP-Seq_ESCs_Human	0.93873500
85	P300_19829295_ChIP-Seq_ESCs_Human	0.92932532
86	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.92767271
87	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.92767271
88	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	0.92609744
89	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.92381236
90	CBP_20019798_ChIP-Seq_JUKART_Human	0.92381236
91	CTCF_27219007_Chip-Seq_Bcells_Human	0.92031277
92	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.91988816
93	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.91054836
94	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.90983368
95	JARID2_20075857_ChIP-Seq_MESCs_Mouse	0.90919441
96	VDR_22108803_ChIP-Seq_LS180_Human	0.90793558
97	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.90058775
98	P53_21459846_ChIP-Seq_SAOS-2_Human	0.89936977
99	OCT4_20526341_ChIP-Seq_ESCs_Human	0.89712563
100	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.89297077

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003880_abnormal_central_pattern	3.27272388
2	MP0006292_abnormal_olfactory_placode	2.94711888
3	MP0001984_abnormal_olfaction	2.94259383
4	MP0005423_abnormal_somatic_nervous	2.91601843
5	MP0004859_abnormal_synaptic_plasticity	2.75545038
6	MP0001529_abnormal_vocalization	2.70875128
7	MP0003787_abnormal_imprinting	2.70723990
8	MP0003136_yellow_coat_color	2.70482765
9	MP0001968_abnormal_touch/_nociception	2.62676243
10	MP0002653_abnormal_ependyma_morphology	2.52804593
11	MP0008877_abnormal_DNA_methylation	2.21980930
12	MP0005394_taste/olfaction_phenotype	2.14591843
13	MP0005499_abnormal_olfactory_system	2.14591843
14	MP0003635_abnormal_synaptic_transmissio	2.10471908
15	MP0005551_abnormal_eye_electrophysiolog	2.09568387
16	MP0001486_abnormal_startle_reflex	2.08152344
17	MP0005646_abnormal_pituitary_gland	2.06589060
18	MP0003122_maternal_imprinting	2.04925520
19	MP0002272_abnormal_nervous_system	2.04799275
20	MP0009745_abnormal_behavioral_response	2.01835259
21	MP0002638_abnormal_pupillary_reflex	2.01701092
22	MP0006276_abnormal_autonomic_nervous	2.00854777
23	MP0008789_abnormal_olfactory_epithelium	1.98567231
24	MP0002736_abnormal_nociception_after	1.93537419
25	MP0004147_increased_porphyrin_level	1.92712683
26	MP0001905_abnormal_dopamine_level	1.88006483
27	MP0002064_seizures	1.78715826
28	MP0004142_abnormal_muscle_tone	1.74006537
29	MP0002735_abnormal_chemical_nociception	1.72388351
30	MP0005410_abnormal_fertilization	1.72381996
31	MP0002572_abnormal_emotion/affect_behav	1.72092043
32	MP0002822_catalepsy	1.71739768
33	MP0002734_abnormal_mechanical_nocicepti	1.70211530
34	MP0005253_abnormal_eye_physiology	1.69147781
35	MP0000778_abnormal_nervous_system	1.66826104
36	MP0003011_delayed_dark_adaptation	1.65978644
37	MP0002063_abnormal_learning/memory/cond	1.65794865
38	MP0005645_abnormal_hypothalamus_physiol	1.63017462
39	MP0009046_muscle_twitch	1.58982232
40	MP0001970_abnormal_pain_threshold	1.58922679
41	MP0002557_abnormal_social/conspecific_i	1.55883701
42	MP0003121_genomic_imprinting	1.45820932
43	MP0006072_abnormal_retinal_apoptosis	1.45449180
44	MP0001293_anophthalmia	1.44941872
45	MP0004270_analgesia	1.42445222
46	MP0005171_absent_coat_pigmentation	1.37423232
47	MP0002733_abnormal_thermal_nociception	1.36510524
48	MP0002067_abnormal_sensory_capabilities	1.36316313
49	MP0001986_abnormal_taste_sensitivity	1.26559618
50	MP0004742_abnormal_vestibular_system	1.25629793
51	MP0009379_abnormal_foot_pigmentation	1.23043365
52	MP0000372_irregular_coat_pigmentation	1.21743167
53	MP0009278_abnormal_bone_marrow	1.21092909
54	MP0006036_abnormal_mitochondrial_physio	1.19772258
55	MP0002752_abnormal_somatic_nervous	1.18547254
56	MP0004133_heterotaxia	1.18032672
57	MP0001963_abnormal_hearing_physiology	1.17216350
58	MP0001502_abnormal_circadian_rhythm	1.17197593
59	MP0000955_abnormal_spinal_cord	1.16460059
60	MP0001485_abnormal_pinna_reflex	1.14135282
61	MP0000631_abnormal_neuroendocrine_gland	1.12230843
62	MP0002882_abnormal_neuron_morphology	1.12229063
63	MP0002102_abnormal_ear_morphology	1.09640584
64	MP0003878_abnormal_ear_physiology	1.08720106
65	MP0005377_hearing/vestibular/ear_phenot	1.08720106
66	MP0005084_abnormal_gallbladder_morpholo	1.06278358
67	MP0008995_early_reproductive_senescence	1.04965641
68	MP0002229_neurodegeneration	1.04643832
69	MP0003698_abnormal_male_reproductive	1.04598082
70	MP0002938_white_spotting	1.03470728
71	MP0002234_abnormal_pharynx_morphology	1.01362370
72	MP0005195_abnormal_posterior_eye	0.99684334
73	MP0008875_abnormal_xenobiotic_pharmacok	0.99309188
74	MP0008058_abnormal_DNA_repair	0.96802149
75	MP0000026_abnormal_inner_ear	0.94854460
76	MP0002066_abnormal_motor_capabilities/c	0.94795855
77	MP0006035_abnormal_mitochondrial_morpho	0.94292638
78	MP0004924_abnormal_behavior	0.93029769
79	MP0005386_behavior/neurological_phenoty	0.93029769
80	MP0001929_abnormal_gametogenesis	0.92843339
81	MP0004885_abnormal_endolymph	0.92402761
82	MP0005174_abnormal_tail_pigmentation	0.89563297
83	MP0004811_abnormal_neuron_physiology	0.89282927
84	MP0003633_abnormal_nervous_system	0.88290723
85	MP0001501_abnormal_sleep_pattern	0.87937449
86	MP0001764_abnormal_homeostasis	0.86848727
87	MP0002095_abnormal_skin_pigmentation	0.85081497
88	MP0008569_lethality_at_weaning	0.84730638
89	MP0008872_abnormal_physiological_respon	0.84380841
90	MP0005391_vision/eye_phenotype	0.83867212
91	MP0005075_abnormal_melanosome_morpholog	0.81972832
92	MP0003718_maternal_effect	0.80658936
93	MP0003137_abnormal_impulse_conducting	0.79886649
94	MP0002152_abnormal_brain_morphology	0.79324629
95	MP0003631_nervous_system_phenotype	0.78405714
96	MP0002751_abnormal_autonomic_nervous	0.77040869
97	MP0002184_abnormal_innervation	0.76362371
98	MP0002210_abnormal_sex_determination	0.76306863
99	MP0003186_abnormal_redox_activity	0.72858213
100	MP0000920_abnormal_myelination	0.69405087

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Myokymia (HP:0002411)	4.15996005
2	Abnormal number of erythroid precursors (HP:0012131)	4.02487963
3	Abnormality of cells of the erythroid lineage (HP:0012130)	3.61507374
4	Acute necrotizing encephalopathy (HP:0006965)	3.56074348
5	Gait imbalance (HP:0002141)	3.47876640
6	Abnormal mitochondria in muscle tissue (HP:0008316)	3.44217460
7	Medial flaring of the eyebrow (HP:0010747)	3.41843719
8	Mitochondrial inheritance (HP:0001427)	3.38149373
9	Microvesicular hepatic steatosis (HP:0001414)	3.29506709
10	Acute encephalopathy (HP:0006846)	3.25010479
11	Hepatocellular necrosis (HP:0001404)	3.22367759
12	Progressive macrocephaly (HP:0004481)	3.15603510
13	Congenital primary aphakia (HP:0007707)	3.09021838
14	Type 2 muscle fiber atrophy (HP:0003554)	3.06162825
15	Increased CSF lactate (HP:0002490)	3.02598132
16	Nephrogenic diabetes insipidus (HP:0009806)	2.99038552
17	Pancreatic fibrosis (HP:0100732)	2.92155444
18	Hepatic necrosis (HP:0002605)	2.89166121
19	Nephronophthisis (HP:0000090)	2.85544351
20	Cerebral edema (HP:0002181)	2.78338320
21	Pancreatic cysts (HP:0001737)	2.77869103
22	Muscle fiber atrophy (HP:0100295)	2.75872580
23	Polyphagia (HP:0002591)	2.75529270
24	Molar tooth sign on MRI (HP:0002419)	2.74640059
25	Abnormality of midbrain morphology (HP:0002418)	2.74640059
26	Cerebral hypomyelination (HP:0006808)	2.70021025
27	True hermaphroditism (HP:0010459)	2.66110492
28	Hyperglycinemia (HP:0002154)	2.55513653
29	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.48644815
30	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.48644815
31	Tubulointerstitial nephritis (HP:0001970)	2.46943862
32	Optic disc pallor (HP:0000543)	2.45174703
33	Type II lissencephaly (HP:0007260)	2.42843069
34	Lactic acidosis (HP:0003128)	2.38097771
35	Abnormality of the renal medulla (HP:0100957)	2.36302969
36	Vaginal atresia (HP:0000148)	2.34400489
37	Rib fusion (HP:0000902)	2.33931348
38	Abnormal rod and cone electroretinograms (HP:0008323)	2.30390654
39	Genital tract atresia (HP:0001827)	2.27183751
40	Congenital stationary night blindness (HP:0007642)	2.25782325
41	Renal Fanconi syndrome (HP:0001994)	2.23720699
42	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.23621204
43	Septo-optic dysplasia (HP:0100842)	2.23508901
44	Decreased central vision (HP:0007663)	2.22692762
45	Increased hepatocellular lipid droplets (HP:0006565)	2.22665224
46	Abnormal drinking behavior (HP:0030082)	2.20252105
47	Polydipsia (HP:0001959)	2.20252105
48	Lipid accumulation in hepatocytes (HP:0006561)	2.18742679
49	Optic nerve hypoplasia (HP:0000609)	2.17670193
50	Attenuation of retinal blood vessels (HP:0007843)	2.16457772
51	Reticulocytopenia (HP:0001896)	2.14561373
52	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.14369611
53	Increased intramyocellular lipid droplets (HP:0012240)	2.14047786
54	Increased serum lactate (HP:0002151)	2.13486736
55	Cerebellar dysplasia (HP:0007033)	2.12733076
56	Focal motor seizures (HP:0011153)	2.11415830
57	Colon cancer (HP:0003003)	2.10846295
58	CNS hypomyelination (HP:0003429)	2.08741632
59	Poor coordination (HP:0002370)	2.08581621
60	Exercise intolerance (HP:0003546)	2.07624409
61	Retinal dysplasia (HP:0007973)	2.05797137
62	Leukodystrophy (HP:0002415)	2.03282127
63	Specific learning disability (HP:0001328)	2.02908913
64	Hemiparesis (HP:0001269)	2.01512773
65	Sclerocornea (HP:0000647)	2.00175452
66	Abolished electroretinogram (ERG) (HP:0000550)	1.98895830
67	Methylmalonic aciduria (HP:0012120)	1.98796669
68	Abnormality of the renal cortex (HP:0011035)	1.98646647
69	Focal seizures (HP:0007359)	1.97201325
70	Abnormality of the labia minora (HP:0012880)	1.95268043
71	Epileptic encephalopathy (HP:0200134)	1.94045753
72	Cystic liver disease (HP:0006706)	1.93514289
73	Polyuria (HP:0000103)	1.92891576
74	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.92483265
75	Respiratory failure (HP:0002878)	1.89945269
76	Pendular nystagmus (HP:0012043)	1.89162573
77	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.87706783
78	Dicarboxylic aciduria (HP:0003215)	1.87484948
79	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.87484948
80	Increased muscle lipid content (HP:0009058)	1.85829220
81	Failure to thrive in infancy (HP:0001531)	1.84420582
82	Chronic hepatic failure (HP:0100626)	1.83243676
83	Tubulointerstitial abnormality (HP:0001969)	1.81747321
84	Postaxial foot polydactyly (HP:0001830)	1.79630020
85	3-Methylglutaconic aciduria (HP:0003535)	1.78865738
86	Renal cortical cysts (HP:0000803)	1.78788408
87	Amyotrophic lateral sclerosis (HP:0007354)	1.76825186
88	Abnormal eating behavior (HP:0100738)	1.76740647
89	Progressive microcephaly (HP:0000253)	1.76028546
90	Retinitis pigmentosa (HP:0000510)	1.75817498
91	Bony spicule pigmentary retinopathy (HP:0007737)	1.75709971
92	Decreased muscle mass (HP:0003199)	1.74860599
93	Severe muscular hypotonia (HP:0006829)	1.74823847
94	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.72857588
95	Hyperglycinuria (HP:0003108)	1.72056296
96	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.71993884
97	Abnormal biliary tract physiology (HP:0012439)	1.71626138
98	Bile duct proliferation (HP:0001408)	1.71626138
99	Hyperthyroidism (HP:0000836)	1.71406750
100	Absent septum pellucidum (HP:0001331)	1.70344533

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	BCKDK	4.11852201
2	MAP4K2	3.23352722
3	VRK2	3.02716110
4	TLK1	2.99863205
5	ZAK	2.63427026
6	CDK19	2.53234417
7	CASK	2.37859590
8	MARK1	2.14609880
9	STK16	2.10194280
10	EPHA4	2.08806553
11	NTRK2	2.05817936
12	BMPR1B	1.99168903
13	WNK3	1.83200630
14	MAPK13	1.75672730
15	DYRK2	1.72345085
16	PDK2	1.68483339
17	MAPK15	1.68186528
18	CSNK1G3	1.57378281
19	MAP3K4	1.57308667
20	CSNK1G2	1.56424001
21	NUAK1	1.56137894
22	TESK2	1.54188995
23	VRK1	1.53466180
24	MAP2K7	1.46123537
25	DAPK2	1.38313912
26	PLK2	1.35606415
27	CDC7	1.34129306
28	PHKG2	1.30958730
29	PHKG1	1.30958730
30	GRK7	1.22098523
31	CSNK1A1L	1.21783892
32	CSNK1G1	1.20374475
33	PRKD3	1.19982165
34	PRKCG	1.18837079
35	PINK1	1.15793456
36	PKN1	1.12720095
37	UHMK1	1.08541751
38	OXSR1	1.04715377
39	FRK	1.03984552
40	PLK4	1.03865469
41	DAPK1	1.01900479
42	NME1	1.00015256
43	LIMK1	0.99857301
44	BCR	0.99824582
45	MINK1	0.99094699
46	PAK6	0.98739020
47	TNK2	0.96898302
48	CAMKK1	0.94989941
49	NTRK3	0.93669742
50	WNK4	0.90267953
51	DYRK1A	0.88427596
52	SRPK1	0.87256784
53	PTK2B	0.86332728
54	GRK1	0.83341461
55	TNIK	0.83036307
56	ADRBK2	0.81836456
57	BUB1	0.76514969
58	STK39	0.75307538
59	CAMK1	0.69472162
60	INSRR	0.67713882
61	KDR	0.66712618
62	CAMK2A	0.66203804
63	RPS6KA5	0.65512659
64	PIM2	0.65245549
65	TRIM28	0.62545293
66	GRK5	0.62257793
67	MKNK1	0.61386064
68	CCNB1	0.59678464
69	CDK5	0.59616623
70	DYRK3	0.57096384
71	NTRK1	0.56143747
72	ADRBK1	0.55693782
73	BRSK1	0.54323789
74	PLK3	0.54310299
75	IKBKB	0.53725095
76	PAK3	0.52723938
77	STK11	0.49748451
78	PRKCE	0.49622112
79	TESK1	0.47620911
80	CSNK1A1	0.47119713
81	CAMK2B	0.46652576
82	DAPK3	0.46483802
83	PLK1	0.45018241
84	MAPKAPK5	0.45016179
85	ABL2	0.44808339
86	CAMKK2	0.44069515
87	MAP2K2	0.44029414
88	FGFR2	0.41988756
89	CAMK2G	0.41632760
90	FLT3	0.41249524
91	PRKCZ	0.41020081
92	ATR	0.40372583
93	PRKACA	0.40165640
94	MAP2K4	0.39416257
95	TAOK3	0.39179823
96	CSNK1D	0.37782151
97	PRKCI	0.37338505
98	CDK11A	0.35971373
99	DYRK1B	0.35692209
100	CDK14	0.35345649

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	3.51891678
2	Parkinsons disease_Homo sapiens_hsa05012	3.14498495
3	Ribosome_Homo sapiens_hsa03010	2.83406007
4	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.73759912
5	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.59503059
6	Nicotine addiction_Homo sapiens_hsa05033	2.37599680
7	Huntingtons disease_Homo sapiens_hsa05016	2.15526408
8	RNA polymerase_Homo sapiens_hsa03020	2.04056983
9	Proteasome_Homo sapiens_hsa03050	2.03050387
10	Fatty acid elongation_Homo sapiens_hsa00062	2.01062727
11	Alzheimers disease_Homo sapiens_hsa05010	1.98181862
12	Phototransduction_Homo sapiens_hsa04744	1.97073199
13	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.91768537
14	Cardiac muscle contraction_Homo sapiens_hsa04260	1.90584984
15	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.80449483
16	Butanoate metabolism_Homo sapiens_hsa00650	1.78064356
17	Base excision repair_Homo sapiens_hsa03410	1.77919343
18	Fanconi anemia pathway_Homo sapiens_hsa03460	1.74128356
19	Propanoate metabolism_Homo sapiens_hsa00640	1.72906070
20	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.71871668
21	Sulfur relay system_Homo sapiens_hsa04122	1.62296724
22	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.54938728
23	Protein export_Homo sapiens_hsa03060	1.49628736
24	beta-Alanine metabolism_Homo sapiens_hsa00410	1.48011517
25	Peroxisome_Homo sapiens_hsa04146	1.47630011
26	Homologous recombination_Homo sapiens_hsa03440	1.42317320
27	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.38260036
28	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.37689664
29	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.34722344
30	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.34324301
31	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.25767951
32	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.24976168
33	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.24591228
34	GABAergic synapse_Homo sapiens_hsa04727	1.22414265
35	Morphine addiction_Homo sapiens_hsa05032	1.17519819
36	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.15921360
37	Linoleic acid metabolism_Homo sapiens_hsa00591	1.12964040
38	Collecting duct acid secretion_Homo sapiens_hsa04966	1.12386386
39	Arginine and proline metabolism_Homo sapiens_hsa00330	1.07628805
40	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.07001477
41	Tryptophan metabolism_Homo sapiens_hsa00380	1.03163802
42	Olfactory transduction_Homo sapiens_hsa04740	1.00773038
43	Mismatch repair_Homo sapiens_hsa03430	0.97410781
44	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.96857782
45	Pyrimidine metabolism_Homo sapiens_hsa00240	0.95633645
46	One carbon pool by folate_Homo sapiens_hsa00670	0.95398890
47	Selenocompound metabolism_Homo sapiens_hsa00450	0.94429475
48	RNA degradation_Homo sapiens_hsa03018	0.92091738
49	Circadian entrainment_Homo sapiens_hsa04713	0.91704171
50	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.89353666
51	Ether lipid metabolism_Homo sapiens_hsa00565	0.89046380
52	Fatty acid degradation_Homo sapiens_hsa00071	0.86888365
53	Purine metabolism_Homo sapiens_hsa00230	0.86384621
54	Insulin secretion_Homo sapiens_hsa04911	0.85873826
55	Regulation of autophagy_Homo sapiens_hsa04140	0.85870449
56	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.84784245
57	Taste transduction_Homo sapiens_hsa04742	0.84420805
58	Amphetamine addiction_Homo sapiens_hsa05031	0.81569891
59	Histidine metabolism_Homo sapiens_hsa00340	0.80998629
60	Spliceosome_Homo sapiens_hsa03040	0.80885409
61	Metabolic pathways_Homo sapiens_hsa01100	0.80265908
62	DNA replication_Homo sapiens_hsa03030	0.79451379
63	Glutamatergic synapse_Homo sapiens_hsa04724	0.78820519
64	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.76643178
65	Nucleotide excision repair_Homo sapiens_hsa03420	0.76490957
66	Asthma_Homo sapiens_hsa05310	0.76352369
67	Nitrogen metabolism_Homo sapiens_hsa00910	0.74685473
68	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.73948195
69	Steroid biosynthesis_Homo sapiens_hsa00100	0.72021767
70	Pyruvate metabolism_Homo sapiens_hsa00620	0.69656256
71	Fatty acid metabolism_Homo sapiens_hsa01212	0.69164379
72	Cocaine addiction_Homo sapiens_hsa05030	0.67150458
73	Carbon metabolism_Homo sapiens_hsa01200	0.65685634
74	Folate biosynthesis_Homo sapiens_hsa00790	0.61793144
75	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.61128820
76	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.57410780
77	Dopaminergic synapse_Homo sapiens_hsa04728	0.56863679
78	Glycerolipid metabolism_Homo sapiens_hsa00561	0.55023237
79	Tyrosine metabolism_Homo sapiens_hsa00350	0.54884874
80	Basal transcription factors_Homo sapiens_hsa03022	0.54696063
81	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.52878863
82	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.51798242
83	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.51676680
84	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.51524859
85	RNA transport_Homo sapiens_hsa03013	0.50403567
86	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.49241239
87	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.49143247
88	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.48496642
89	Glutathione metabolism_Homo sapiens_hsa00480	0.48414642
90	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.46371845
91	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.45965520
92	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.45924089
93	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.45604026
94	Salivary secretion_Homo sapiens_hsa04970	0.43852471
95	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.43187330
96	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.42924877
97	Chemical carcinogenesis_Homo sapiens_hsa05204	0.42355025
98	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.42034828
99	Calcium signaling pathway_Homo sapiens_hsa04020	0.37966446
100	Serotonergic synapse_Homo sapiens_hsa04726	0.37075196

FAHD2CP

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »