FAIM

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene protects against death receptor-triggered apoptosis and regulates B-cell signaling and differentiation. Several transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of rhodopsin mediated signaling pathway (GO:0022400)5.72354691
2rhodopsin mediated signaling pathway (GO:0016056)5.44564691
3chaperone-mediated protein transport (GO:0072321)4.87292518
4mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.72587977
5retinal cone cell development (GO:0046549)4.54588098
6sensory perception of smell (GO:0007608)4.43949126
7energy coupled proton transport, down electrochemical gradient (GO:0015985)4.02318067
8ATP synthesis coupled proton transport (GO:0015986)4.02318067
9photoreceptor cell maintenance (GO:0045494)3.99631007
10establishment of protein localization to mitochondrial membrane (GO:0090151)3.98392984
11rRNA modification (GO:0000154)3.93433517
12mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.92180126
13pseudouridine synthesis (GO:0001522)3.85247768
14maturation of SSU-rRNA (GO:0030490)3.81328136
15GMP metabolic process (GO:0046037)3.77490670
16detection of light stimulus involved in visual perception (GO:0050908)3.64130048
17detection of light stimulus involved in sensory perception (GO:0050962)3.64130048
18DNA replication checkpoint (GO:0000076)3.62439899
19protein targeting to mitochondrion (GO:0006626)3.53106513
20respiratory electron transport chain (GO:0022904)3.52656836
21ribosomal large subunit biogenesis (GO:0042273)3.51915012
22regulation of mitochondrial translation (GO:0070129)3.50636413
23electron transport chain (GO:0022900)3.49076349
24water-soluble vitamin biosynthetic process (GO:0042364)3.48068598
25chromatin remodeling at centromere (GO:0031055)3.47889832
26GTP biosynthetic process (GO:0006183)3.47613904
27CENP-A containing nucleosome assembly (GO:0034080)3.47588074
28maturation of 5.8S rRNA (GO:0000460)3.45771216
29ribosome assembly (GO:0042255)3.42862655
30protein localization to cilium (GO:0061512)3.42454293
31sequestering of actin monomers (GO:0042989)3.42181502
32deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.39982950
33rRNA methylation (GO:0031167)3.38894160
34rRNA processing (GO:0006364)3.36578356
35photoreceptor cell development (GO:0042461)3.35919763
36purine nucleobase biosynthetic process (GO:0009113)3.35624673
37DNA deamination (GO:0045006)3.33400543
38transcription from mitochondrial promoter (GO:0006390)3.32769235
39RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.32360919
40tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.32360919
41rRNA metabolic process (GO:0016072)3.32179849
42pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.29205344
43protein complex biogenesis (GO:0070271)3.26852881
44pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.26626159
45nonmotile primary cilium assembly (GO:0035058)3.26324575
46preassembly of GPI anchor in ER membrane (GO:0016254)3.26099294
47ribosomal small subunit biogenesis (GO:0042274)3.25627149
48nucleobase biosynthetic process (GO:0046112)3.24083021
49mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.21382872
50mitochondrial respiratory chain complex I assembly (GO:0032981)3.21382872
51NADH dehydrogenase complex assembly (GO:0010257)3.21382872
52guanosine-containing compound biosynthetic process (GO:1901070)3.20498631
53sensory perception of chemical stimulus (GO:0007606)3.19975655
54nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.19727135
55transcription elongation from RNA polymerase III promoter (GO:0006385)3.18685169
56termination of RNA polymerase III transcription (GO:0006386)3.18685169
57CTP biosynthetic process (GO:0006241)3.17576724
58CTP metabolic process (GO:0046036)3.17576724
59mitochondrial RNA metabolic process (GO:0000959)3.17351901
60protein localization to mitochondrion (GO:0070585)3.16660642
61snRNA transcription (GO:0009301)3.15905748
62eye photoreceptor cell development (GO:0042462)3.14694654
63DNA double-strand break processing (GO:0000729)3.14468793
64establishment of protein localization to mitochondrion (GO:0072655)3.13319736
65exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.12252599
66UTP biosynthetic process (GO:0006228)3.09870016
67olfactory bulb development (GO:0021772)3.08844150
68cellular component biogenesis (GO:0044085)3.08052814
69establishment of integrated proviral latency (GO:0075713)3.06526509
70negative regulation of transcription regulatory region DNA binding (GO:2000678)3.02610476
71protein insertion into membrane (GO:0051205)3.02522085
72intraciliary transport (GO:0042073)3.02402968
73translation (GO:0006412)3.02032458
74anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.97785648
75spliceosomal snRNP assembly (GO:0000387)2.97549674
76pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.95351872
77proteasome assembly (GO:0043248)2.93542828
78mitochondrial respiratory chain complex assembly (GO:0033108)2.93402508
79UTP metabolic process (GO:0046051)2.92569858
80pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.91985981
81base-excision repair, AP site formation (GO:0006285)2.91974938
82pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.91964002
83ribonucleoprotein complex biogenesis (GO:0022613)2.91061175
84histone exchange (GO:0043486)2.89387046
85synapsis (GO:0007129)2.87379934
86telomere maintenance via semi-conservative replication (GO:0032201)2.85388016
87respiratory chain complex IV assembly (GO:0008535)2.84836214
88histone mRNA metabolic process (GO:0008334)2.84196991
89negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 2.84196817
90intracellular protein transmembrane import (GO:0044743)2.83474336
91cellular response to virus (GO:0098586)2.83171087
927-methylguanosine mRNA capping (GO:0006370)2.81418053
93pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.80179761
94DNA damage response, detection of DNA damage (GO:0042769)2.79364627
95tRNA processing (GO:0008033)2.78813255
967-methylguanosine RNA capping (GO:0009452)2.77968076
97RNA capping (GO:0036260)2.77968076
98protein neddylation (GO:0045116)2.77578881
99replication fork processing (GO:0031297)2.77073105
100phototransduction (GO:0007602)2.76617188
101SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.76197979
102regulation of chromatin binding (GO:0035561)2.75177914
103histone H2A acetylation (GO:0043968)2.74749121
104DNA ligation (GO:0006266)2.74249530
105C-terminal protein lipidation (GO:0006501)2.74185784
106DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.73869749
107DNA catabolic process, exonucleolytic (GO:0000738)2.73779988
108purine nucleotide salvage (GO:0032261)2.73672555
109cotranslational protein targeting to membrane (GO:0006613)2.73409488
110ncRNA processing (GO:0034470)2.73201692
111mitochondrial transport (GO:0006839)2.72448780
112ncRNA metabolic process (GO:0034660)2.71853526
113purine nucleoside triphosphate biosynthetic process (GO:0009145)2.71473929
114detection of visible light (GO:0009584)2.71355313
115positive regulation of guanylate cyclase activity (GO:0031284)2.70873457
116detection of light stimulus (GO:0009583)2.70038506
117negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.69762745
118signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.69708724
119signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.69708724
120signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.69708724
121oxidative phosphorylation (GO:0006119)2.68948981
122cytochrome complex assembly (GO:0017004)2.66991333
123positive regulation of oligodendrocyte differentiation (GO:0048714)2.66769754
124cullin deneddylation (GO:0010388)2.65963497
125phototransduction, visible light (GO:0007603)2.65904050
126axon ensheathment in central nervous system (GO:0032291)2.62604309
127central nervous system myelination (GO:0022010)2.62604309
128natural killer cell mediated cytotoxicity (GO:0042267)2.62205173
129natural killer cell mediated immunity (GO:0002228)2.62205173
130telomere maintenance via recombination (GO:0000722)2.61703561
131interferon-gamma production (GO:0032609)2.60273340
132establishment of viral latency (GO:0019043)2.57096556
133visual perception (GO:0007601)2.54903103
134negative regulation of mast cell activation (GO:0033004)2.53432146
135viral mRNA export from host cell nucleus (GO:0046784)2.52953231
136protein deneddylation (GO:0000338)2.52101871
137sensory perception of light stimulus (GO:0050953)2.51814458
138pyrimidine nucleotide catabolic process (GO:0006244)2.51389604
139peptidyl-histidine modification (GO:0018202)2.50339710
140antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.45762668
141regulation of double-strand break repair via homologous recombination (GO:0010569)2.45487895
142positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.45461152
143protein polyglutamylation (GO:0018095)2.44475132
144regulation of MHC class II biosynthetic process (GO:0045346)2.44320372
145DNA strand elongation involved in DNA replication (GO:0006271)2.44150777
146deoxyribose phosphate biosynthetic process (GO:0046385)2.44140010
1472-deoxyribonucleotide biosynthetic process (GO:0009265)2.44140010
148regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.43351948
149protein-chromophore linkage (GO:0018298)2.43247751
150DNA strand elongation (GO:0022616)2.42685220
151antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.42447367
152positive regulation of DNA-templated transcription, elongation (GO:0032786)2.41786600
153regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 2.40540479
154L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.39721020
155nucleotide-excision repair, DNA gap filling (GO:0006297)2.37488647
156negative regulation of ligase activity (GO:0051352)2.36506562
157negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.36506562
158regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.35809968
159regulation of guanylate cyclase activity (GO:0031282)2.35590455
160deoxyribonucleotide catabolic process (GO:0009264)2.34176531
161organelle disassembly (GO:1903008)2.33678314
162deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.33554856
163regulation of cellular amino acid metabolic process (GO:0006521)2.33511508
164negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)2.31500274
165transcription-coupled nucleotide-excision repair (GO:0006283)2.30727394
166neutrophil activation involved in immune response (GO:0002283)2.30074997
167megakaryocyte development (GO:0035855)2.29837810
168regulation of mitotic spindle checkpoint (GO:1903504)2.29467309
169regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.29467309

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.82889341
2ELF1_17652178_ChIP-ChIP_JURKAT_Human3.45436533
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.29216600
4RBPJ_22232070_ChIP-Seq_NCS_Mouse3.26628580
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.24492395
6EZH2_22144423_ChIP-Seq_EOC_Human3.16647407
7EST1_17652178_ChIP-ChIP_JURKAT_Human2.99277914
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.91480068
9E2F7_22180533_ChIP-Seq_HELA_Human2.71961786
10HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.64810898
11IRF8_22096565_ChIP-ChIP_GC-B_Human2.64794207
12TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.64197608
13VDR_23849224_ChIP-Seq_CD4+_Human2.28448426
14IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.23207265
15FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.17781066
16BP1_19119308_ChIP-ChIP_Hs578T_Human2.15182888
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.12987082
18ETS1_20019798_ChIP-Seq_JURKAT_Human2.05424927
19ZNF274_21170338_ChIP-Seq_K562_Hela2.05073473
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.97171054
21ELK1_19687146_ChIP-ChIP_HELA_Human1.97023118
22MYC_18555785_ChIP-Seq_MESCs_Mouse1.96511031
23SRF_21415370_ChIP-Seq_HL-1_Mouse1.92888039
24HOXB4_20404135_ChIP-ChIP_EML_Mouse1.91921902
25CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.88959073
26SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.88016487
27FOXP3_21729870_ChIP-Seq_TREG_Human1.86090459
28MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.84780319
29TAF15_26573619_Chip-Seq_HEK293_Human1.84500199
30SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.83315625
31PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.82769548
32HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.81048222
33CREB1_15753290_ChIP-ChIP_HEK293T_Human1.77426326
34DCP1A_22483619_ChIP-Seq_HELA_Human1.75463849
35FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.73106204
36MYC_19079543_ChIP-ChIP_MESCs_Mouse1.70176934
37FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.70045247
38THAP11_20581084_ChIP-Seq_MESCs_Mouse1.69215921
39IRF8_21731497_ChIP-ChIP_J774_Mouse1.69006503
40YY1_21170310_ChIP-Seq_MESCs_Mouse1.62322398
41MYC_18358816_ChIP-ChIP_MESCs_Mouse1.62297108
42MYC_19030024_ChIP-ChIP_MESCs_Mouse1.57209144
43POU3F2_20337985_ChIP-ChIP_501MEL_Human1.55747500
44NOTCH1_21737748_ChIP-Seq_TLL_Human1.55738614
45EWS_26573619_Chip-Seq_HEK293_Human1.52616831
46* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.51923548
47E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.51632296
48IGF1R_20145208_ChIP-Seq_DFB_Human1.51499386
49E2F4_17652178_ChIP-ChIP_JURKAT_Human1.49506464
50PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.48635655
51TTF2_22483619_ChIP-Seq_HELA_Human1.47817827
52ZFP57_27257070_Chip-Seq_ESCs_Mouse1.44135468
53CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.42310462
54SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.41771279
55FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.40868848
56SALL1_21062744_ChIP-ChIP_HESCs_Human1.40545200
57E2F1_18555785_ChIP-Seq_MESCs_Mouse1.38825653
58GABP_19822575_ChIP-Seq_HepG2_Human1.38110358
59YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.37598868
60VDR_22108803_ChIP-Seq_LS180_Human1.37502943
61ERG_20887958_ChIP-Seq_HPC-7_Mouse1.37226988
62TP63_19390658_ChIP-ChIP_HaCaT_Human1.37078730
63AR_21909140_ChIP-Seq_LNCAP_Human1.35683808
64EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.33667465
65RNF2_27304074_Chip-Seq_NSC_Mouse1.31318710
66ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.29226670
67* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.26052055
68STAT4_19710469_ChIP-ChIP_TH1__Mouse1.25210328
69HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.25175805
70MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.23917196
71EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.23664939
72CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.22202046
73PCGF2_27294783_Chip-Seq_ESCs_Mouse1.21143731
74XRN2_22483619_ChIP-Seq_HELA_Human1.21022066
75CIITA_25753668_ChIP-Seq_RAJI_Human1.20870218
76SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.19783415
77ELK1_22589737_ChIP-Seq_MCF10A_Human1.18650186
78KDM5A_27292631_Chip-Seq_BREAST_Human1.16725045
79TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.16016623
80SPI1_23547873_ChIP-Seq_NB4_Human1.14953663
81GBX2_23144817_ChIP-Seq_PC3_Human1.14774425
82CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.12673794
83FUS_26573619_Chip-Seq_HEK293_Human1.12641639
84IRF1_19129219_ChIP-ChIP_H3396_Human1.11451336
85E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.11036021
86KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.10590932
87FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.09073805
88* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.05686547
89FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.04642282
90FLI1_27457419_Chip-Seq_LIVER_Mouse1.04632668
91CTBP2_25329375_ChIP-Seq_LNCAP_Human1.03261479
92MYC_18940864_ChIP-ChIP_HL60_Human1.02967769
93PADI4_21655091_ChIP-ChIP_MCF-7_Human1.02013053
94TP53_22573176_ChIP-Seq_HFKS_Human1.01677261
95GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.00207031
96MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.00135982
97GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00029781
98* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.99516588
99CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.99032513
100CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.98334642
101POU5F1_16153702_ChIP-ChIP_HESCs_Human0.98238131
102FOXM1_23109430_ChIP-Seq_U2OS_Human0.98208024
103HTT_18923047_ChIP-ChIP_STHdh_Human0.96208696
104MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.96142235
105CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.95240368
106FOXA1_25329375_ChIP-Seq_VCAP_Human0.93607915
107FOXA1_27270436_Chip-Seq_PROSTATE_Human0.93607915
108CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.93251895
109PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.91184777
110LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.90663519
111IKZF1_21737484_ChIP-ChIP_HCT116_Human0.90284072
112AR_20517297_ChIP-Seq_VCAP_Human0.90203608
113P300_19829295_ChIP-Seq_ESCs_Human0.90101372
114SOX2_18555785_ChIP-Seq_MESCs_Mouse0.89571328
115CBX2_27304074_Chip-Seq_ESCs_Mouse0.89269098
116ELF5_23300383_ChIP-Seq_T47D_Human0.88861050
117* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.88329028
118E2F1_21310950_ChIP-Seq_MCF-7_Human0.87051129
119MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.86979528
120RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.86098417
121ER_23166858_ChIP-Seq_MCF-7_Human0.86084476
122CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85079529
123SUZ12_18555785_Chip-Seq_ESCs_Mouse0.84990304
124ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.83867657
125NCOR_22424771_ChIP-Seq_293T_Human0.83557450
126EZH2_27294783_Chip-Seq_NPCs_Mouse0.82688076
127UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.82217642
128MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.82195385
129CTBP1_25329375_ChIP-Seq_LNCAP_Human0.80951467
130POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.80705660
131SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.79052616
132MYCN_18555785_ChIP-Seq_MESCs_Mouse0.78526680
133* NANOG_19829295_ChIP-Seq_ESCs_Human0.77648412
134POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.77373149
135EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.77201350

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001984_abnormal_olfaction4.90437133
2MP0008789_abnormal_olfactory_epithelium3.73247411
3MP0005551_abnormal_eye_electrophysiolog3.49461683
4MP0003806_abnormal_nucleotide_metabolis3.42364932
5MP0005394_taste/olfaction_phenotype3.17943863
6MP0005499_abnormal_olfactory_system3.17943863
7MP0005645_abnormal_hypothalamus_physiol2.79272024
8MP0005379_endocrine/exocrine_gland_phen2.45826906
9MP0005253_abnormal_eye_physiology2.43017507
10MP0003693_abnormal_embryo_hatching2.37802685
11MP0002837_dystrophic_cardiac_calcinosis2.35236663
12MP0003195_calcinosis2.18286849
13MP0008058_abnormal_DNA_repair2.18013333
14MP0006072_abnormal_retinal_apoptosis2.16369841
15MP0006036_abnormal_mitochondrial_physio2.07630531
16MP0002638_abnormal_pupillary_reflex2.06062252
17MP0001986_abnormal_taste_sensitivity2.01455331
18MP0006292_abnormal_olfactory_placode2.00036420
19MP0001188_hyperpigmentation1.99292909
20MP0003718_maternal_effect1.98075700
21MP0003123_paternal_imprinting1.95213036
22MP0004147_increased_porphyrin_level1.94342618
23MP0005670_abnormal_white_adipose1.91546472
24MP0003011_delayed_dark_adaptation1.85092087
25MP0001835_abnormal_antigen_presentation1.83225297
26MP0009697_abnormal_copulation1.77950960
27MP0003786_premature_aging1.77656462
28MP0008875_abnormal_xenobiotic_pharmacok1.76837477
29MP0005671_abnormal_response_to1.73556611
30MP0009785_altered_susceptibility_to1.70996693
31MP0008057_abnormal_DNA_replication1.68554921
32MP0005423_abnormal_somatic_nervous1.67440538
33MP0002160_abnormal_reproductive_system1.66165104
34MP0006276_abnormal_autonomic_nervous1.61329971
35MP0010094_abnormal_chromosome_stability1.57165871
36MP0000372_irregular_coat_pigmentation1.56771054
37MP0003941_abnormal_skin_development1.56604042
38MP0002148_abnormal_hypersensitivity_rea1.53519037
39MP0008877_abnormal_DNA_methylation1.51015025
40MP0003890_abnormal_embryonic-extraembry1.48123031
41MP0001542_abnormal_bone_strength1.46816930
42MP0005195_abnormal_posterior_eye1.43908803
43MP0002876_abnormal_thyroid_physiology1.42656624
44MP0003787_abnormal_imprinting1.42600210
45MP0000015_abnormal_ear_pigmentation1.41307180
46MP0005410_abnormal_fertilization1.39740983
47MP0002138_abnormal_hepatobiliary_system1.39575748
48MP0001485_abnormal_pinna_reflex1.36369554
49MP0005171_absent_coat_pigmentation1.36024037
50MP0002752_abnormal_somatic_nervous1.35897516
51MP0001905_abnormal_dopamine_level1.35786058
52MP0002184_abnormal_innervation1.33529514
53MP0005391_vision/eye_phenotype1.33129718
54MP0006035_abnormal_mitochondrial_morpho1.33059796
55MP0009333_abnormal_splenocyte_physiolog1.31786433
56MP0005174_abnormal_tail_pigmentation1.31473914
57MP0002102_abnormal_ear_morphology1.29595707
58MP0001324_abnormal_eye_pigmentation1.27442017
59MP0000490_abnormal_crypts_of1.26910582
60MP0008260_abnormal_autophagy1.26126088
61MP0003880_abnormal_central_pattern1.26104151
62* MP0003763_abnormal_thymus_physiology1.25651230
63MP0005000_abnormal_immune_tolerance1.21048834
64MP0004742_abnormal_vestibular_system1.20905418
65MP0010386_abnormal_urinary_bladder1.18431869
66MP0005332_abnormal_amino_acid1.18181164
67MP0001293_anophthalmia1.16511904
68MP0006054_spinal_hemorrhage1.14618280
69MP0005646_abnormal_pituitary_gland1.13152821
70* MP0001819_abnormal_immune_cell1.11674416
71MP0005220_abnormal_exocrine_pancreas1.11234271
72MP0005025_abnormal_response_to1.11191307
73* MP0002420_abnormal_adaptive_immunity1.10935283
74MP0002723_abnormal_immune_serum1.08891924
75* MP0002452_abnormal_antigen_presenting1.08395128
76MP0002210_abnormal_sex_determination1.08135998
77MP0001929_abnormal_gametogenesis1.07956457
78MP0002090_abnormal_vision1.06073135
79MP0002132_abnormal_respiratory_system1.05628576
80MP0001853_heart_inflammation1.05042664
81MP0003136_yellow_coat_color1.04548675
82MP0003724_increased_susceptibility_to1.04420331
83MP0000778_abnormal_nervous_system1.04151232
84MP0001529_abnormal_vocalization1.03511982
85MP0002272_abnormal_nervous_system1.03204944
86MP0002882_abnormal_neuron_morphology1.03151578
87MP0003077_abnormal_cell_cycle1.02511791
88MP0002229_neurodegeneration1.02216446
89MP0001145_abnormal_male_reproductive1.01888596
90MP0002419_abnormal_innate_immunity1.01670075
91MP0002398_abnormal_bone_marrow1.00457963
92MP0005075_abnormal_melanosome_morpholog0.99406052
93MP0003937_abnormal_limbs/digits/tail_de0.99334628
94MP0002734_abnormal_mechanical_nocicepti0.99276365
95MP0006082_CNS_inflammation0.99102232
96MP0009046_muscle_twitch0.98744595
97MP0001800_abnormal_humoral_immune0.98341402
98MP0001919_abnormal_reproductive_system0.97938929
99MP0008872_abnormal_physiological_respon0.97377226
100MP0000653_abnormal_sex_gland0.95709449
101MP0004133_heterotaxia0.95370769
102MP0008007_abnormal_cellular_replicative0.94997783
103MP0005389_reproductive_system_phenotype0.94657002
104MP0002234_abnormal_pharynx_morphology0.94058151
105MP0002736_abnormal_nociception_after0.93409287
106MP0002909_abnormal_adrenal_gland0.92780732
107MP0000358_abnormal_cell_content/0.91783480
108MP0003698_abnormal_male_reproductive0.91465556
109MP0002928_abnormal_bile_duct0.91408973
110MP0004957_abnormal_blastocyst_morpholog0.90635561
111MP0003950_abnormal_plasma_membrane0.90455077
112MP0000538_abnormal_urinary_bladder0.89049124
113MP0004215_abnormal_myocardial_fiber0.88390174
114MP0000716_abnormal_immune_system0.88262835
115MP0000516_abnormal_urinary_system0.87973413
116MP0005367_renal/urinary_system_phenotyp0.87973413
117MP0000049_abnormal_middle_ear0.87415285
118MP0003436_decreased_susceptibility_to0.87289328
119MP0001727_abnormal_embryo_implantation0.86935110
120MP0002938_white_spotting0.86178432
121MP0003252_abnormal_bile_duct0.86120985
122MP0003121_genomic_imprinting0.85936147
123MP0001764_abnormal_homeostasis0.85894608
124MP0003567_abnormal_fetal_cardiomyocyte0.85715940
125MP0000647_abnormal_sebaceous_gland0.85586963
126MP0004142_abnormal_muscle_tone0.84863553
127MP0003186_abnormal_redox_activity0.84663679
128MP0005647_abnormal_sex_gland0.83593940
129MP0002163_abnormal_gland_morphology0.82415594
130MP0005084_abnormal_gallbladder_morpholo0.82201712
131MP0002735_abnormal_chemical_nociception0.82161112
132MP0001790_abnormal_immune_system0.82097132
133MP0005387_immune_system_phenotype0.82097132
134MP0000383_abnormal_hair_follicle0.81282449
135MP0002277_abnormal_respiratory_mucosa0.80646994
136MP0004782_abnormal_surfactant_physiolog0.79867150
137MP0010678_abnormal_skin_adnexa0.79411478
138MP0005310_abnormal_salivary_gland0.78593191
139MP0002751_abnormal_autonomic_nervous0.77773517
140MP0009780_abnormal_chondrocyte_physiolo0.76954068
141MP0002095_abnormal_skin_pigmentation0.76880104
142MP0008932_abnormal_embryonic_tissue0.76756543
143MP0009250_abnormal_appendicular_skeleto0.75797962
144MP0000427_abnormal_hair_cycle0.75381688
145MP0001502_abnormal_circadian_rhythm0.74978664
146MP0000631_abnormal_neuroendocrine_gland0.74484489
147MP0001730_embryonic_growth_arrest0.74210278
148MP0002429_abnormal_blood_cell0.73121934
149MP0002282_abnormal_trachea_morphology0.73058121
150MP0005408_hypopigmentation0.72972722
151MP0000026_abnormal_inner_ear0.72753965
152MP0002405_respiratory_system_inflammati0.72384798
153MP0002396_abnormal_hematopoietic_system0.71586596
154MP0002653_abnormal_ependyma_morphology0.71163994
155MP0003111_abnormal_nucleus_morphology0.71063507
156MP0003646_muscle_fatigue0.69244199
157MP0005187_abnormal_penis_morphology0.68788055
158MP0002177_abnormal_outer_ear0.68572435

Predicted human phenotypes

RankGene SetZ-score
1Dyschromatopsia (HP:0007641)5.54478569
2Congenital stationary night blindness (HP:0007642)5.43909114
3Absent rod-and cone-mediated responses on ERG (HP:0007688)5.16992952
4Bony spicule pigmentary retinopathy (HP:0007737)4.94570185
5Abnormal rod and cone electroretinograms (HP:0008323)4.81123665
6Attenuation of retinal blood vessels (HP:0007843)4.52095367
7Abnormality of macular pigmentation (HP:0008002)4.47626269
8Pendular nystagmus (HP:0012043)4.03798017
9Medial flaring of the eyebrow (HP:0010747)3.97570293
10Gait imbalance (HP:0002141)3.89192882
11Congenital primary aphakia (HP:0007707)3.87074193
12Nephrogenic diabetes insipidus (HP:0009806)3.73188200
13Decreased central vision (HP:0007663)3.60587845
14Pancreatic fibrosis (HP:0100732)3.51818784
15True hermaphroditism (HP:0010459)3.49809787
16Type I transferrin isoform profile (HP:0003642)3.40501125
17Choroideremia (HP:0001139)3.24875360
18Severe visual impairment (HP:0001141)3.24782034
19Cerebral edema (HP:0002181)3.12876155
20Hepatic necrosis (HP:0002605)3.06029698
21Hypothermia (HP:0002045)3.05551697
22Central scotoma (HP:0000603)3.00423356
23Absent/shortened dynein arms (HP:0200106)3.00087489
24Dynein arm defect of respiratory motile cilia (HP:0012255)3.00087489
25Abolished electroretinogram (ERG) (HP:0000550)2.99795007
26Acute necrotizing encephalopathy (HP:0006965)2.95684477
27Generalized aminoaciduria (HP:0002909)2.92746953
28Optic disc pallor (HP:0000543)2.86410254
29Abnormal respiratory epithelium morphology (HP:0012253)2.85449229
30Abnormal respiratory motile cilium morphology (HP:0005938)2.85449229
31Constricted visual fields (HP:0001133)2.81008324
32Renal cortical cysts (HP:0000803)2.80076138
33Poor coordination (HP:0002370)2.79394253
34Genital tract atresia (HP:0001827)2.75765952
35Pancreatic cysts (HP:0001737)2.75412319
36Aplasia/Hypoplasia of the lens (HP:0008063)2.75133112
37Photophobia (HP:0000613)2.73869492
38Degeneration of anterior horn cells (HP:0002398)2.73512522
39Abnormality of the anterior horn cell (HP:0006802)2.73512522
40Molar tooth sign on MRI (HP:0002419)2.70258130
41Abnormality of midbrain morphology (HP:0002418)2.70258130
42Abnormal respiratory motile cilium physiology (HP:0012261)2.68478317
43Retinitis pigmentosa (HP:0000510)2.64285458
44Pigmentary retinal degeneration (HP:0001146)2.64268866
45Abnormal mitochondria in muscle tissue (HP:0008316)2.63409558
46Vaginal atresia (HP:0000148)2.62684281
47Lactic acidosis (HP:0003128)2.61192307
48Respiratory failure (HP:0002878)2.57175699
49Abnormal ciliary motility (HP:0012262)2.56620223
50Decreased testicular size (HP:0008734)2.52905797
51Mitochondrial inheritance (HP:0001427)2.52066161
52Abnormal protein glycosylation (HP:0012346)2.50406071
53Abnormal glycosylation (HP:0012345)2.50406071
54Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.50406071
55Abnormal protein N-linked glycosylation (HP:0012347)2.50406071
56Microvesicular hepatic steatosis (HP:0001414)2.50157931
57Progressive macrocephaly (HP:0004481)2.43435984
58Abnormality of the renal cortex (HP:0011035)2.42764265
59Scotoma (HP:0000575)2.42743274
60Retinal dysplasia (HP:0007973)2.29731839
61Respiratory difficulties (HP:0002880)2.29409757
62Glycosuria (HP:0003076)2.29150050
63Abnormality of urine glucose concentration (HP:0011016)2.29150050
64Chorioretinal atrophy (HP:0000533)2.27289626
65Abnormal hair whorl (HP:0010721)2.27135933
663-Methylglutaconic aciduria (HP:0003535)2.25184598
67Increased intramyocellular lipid droplets (HP:0012240)2.24823958
68Lethargy (HP:0001254)2.22689622
69Renal Fanconi syndrome (HP:0001994)2.18619701
70Retrobulbar optic neuritis (HP:0100654)2.18427754
71Optic neuritis (HP:0100653)2.18427754
72Anencephaly (HP:0002323)2.16819245
73Type II lissencephaly (HP:0007260)2.15513215
74Increased IgM level (HP:0003496)2.13220369
75Birth length less than 3rd percentile (HP:0003561)2.13196083
76Rhinitis (HP:0012384)2.12469971
77Increased CSF lactate (HP:0002490)2.11424639
78Reduced antithrombin III activity (HP:0001976)2.09512024
79Methylmalonic acidemia (HP:0002912)2.09082985
80Increased hepatocellular lipid droplets (HP:0006565)2.08508998
81Abnormality of the renal medulla (HP:0100957)2.08424537
82Type II diabetes mellitus (HP:0005978)2.07024790
83Increased serum pyruvate (HP:0003542)2.06823386
84Abnormality of cells of the erythroid lineage (HP:0012130)2.05747287
85Increased corneal curvature (HP:0100692)2.00494790
86Keratoconus (HP:0000563)2.00494790
87Congenital sensorineural hearing impairment (HP:0008527)2.00136163
88Exercise intolerance (HP:0003546)1.99926890
89Abnormality of methionine metabolism (HP:0010901)1.99341279
90Methylmalonic aciduria (HP:0012120)1.99284803
91Optic nerve coloboma (HP:0000588)1.97885344
92Nephronophthisis (HP:0000090)1.97301143
93Abnormal number of erythroid precursors (HP:0012131)1.97051033
94Anosmia (HP:0000458)1.96946434
95Severe combined immunodeficiency (HP:0004430)1.96750571
96Aplasia/Hypoplasia of the tongue (HP:0010295)1.96626368
97Limb dystonia (HP:0002451)1.96487457
98Increased muscle lipid content (HP:0009058)1.96195249
99Macrocytic anemia (HP:0001972)1.95850223
100Recurrent abscess formation (HP:0002722)1.95760915
101Exertional dyspnea (HP:0002875)1.95086469
102Hepatocellular necrosis (HP:0001404)1.94637794
103Abnormality of the pons (HP:0007361)1.94465782
104Abnormality of serum amino acid levels (HP:0003112)1.93898816
105Aplasia/hypoplasia of the uterus (HP:0008684)1.93392214
106Type 2 muscle fiber atrophy (HP:0003554)1.93325521
107Abnormality of chromosome stability (HP:0003220)1.92779065
108Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.92411672
109Hyperglycinemia (HP:0002154)1.92071182
110Acute encephalopathy (HP:0006846)1.91997740
111Aplastic anemia (HP:0001915)1.91741526
112Stenosis of the external auditory canal (HP:0000402)1.91556238
113Preaxial hand polydactyly (HP:0001177)1.91541434
114Postaxial foot polydactyly (HP:0001830)1.91441391
115Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.86882618
116Abnormality of alanine metabolism (HP:0010916)1.86882618
117Hyperalaninemia (HP:0003348)1.86882618
118Postaxial hand polydactyly (HP:0001162)1.85505466
119Aganglionic megacolon (HP:0002251)1.84637337
120Sclerocornea (HP:0000647)1.84341526
121Leukodystrophy (HP:0002415)1.83676684
122Abnormality of the preputium (HP:0100587)1.83083426
123Petechiae (HP:0000967)1.83021192
124Meckel diverticulum (HP:0002245)1.81508727
125CNS demyelination (HP:0007305)1.81275456
126Aplasia/Hypoplasia of the uvula (HP:0010293)1.80958953
127Abnormality of renal resorption (HP:0011038)1.80060953
128Median cleft lip (HP:0000161)1.79592681
129Chromosomal breakage induced by crosslinking agents (HP:0003221)1.79277162
130Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.79166478
131Thyroiditis (HP:0100646)1.78571861
132Hyperglycinuria (HP:0003108)1.78101932
133Volvulus (HP:0002580)1.78037564
134Cystic liver disease (HP:0006706)1.77201471
135Muscle fiber atrophy (HP:0100295)1.77122204
136Absent thumb (HP:0009777)1.76981736
137Male pseudohermaphroditism (HP:0000037)1.76878569
138Abnormality of the ileum (HP:0001549)1.76848877
139Chromsome breakage (HP:0040012)1.75462281
140Patchy hypopigmentation of hair (HP:0011365)1.73833267
141Furrowed tongue (HP:0000221)1.71368962
142Astigmatism (HP:0000483)1.71113435
143Bifid tongue (HP:0010297)1.71013267
144Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.70937769
145Broad foot (HP:0001769)1.70853284
146Macular degeneration (HP:0000608)1.69910799
147Lipid accumulation in hepatocytes (HP:0006561)1.69028234
148Reticulocytopenia (HP:0001896)1.68767929
149Testicular atrophy (HP:0000029)1.68752224
150Abnormality of macrophages (HP:0004311)1.67780266
151Decreased electroretinogram (ERG) amplitude (HP:0000654)1.65521714
152Increased serum lactate (HP:0002151)1.63843138
153Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.63624581
154Decreased activity of mitochondrial respiratory chain (HP:0008972)1.63624581
155Premature graying of hair (HP:0002216)1.63322425

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.56863991
2PBK3.00243385
3STK162.99383694
4VRK22.71595791
5SIK32.70550124
6TXK2.69324620
7NEK12.51981032
8ERBB32.51579022
9PDK22.51253863
10PIM22.40702248
11IRAK42.40026356
12ARAF2.39472020
13GRK12.35031869
14SRPK12.11865653
15TRIM282.07028353
16MAP2K72.00353410
17BMPR21.99063018
18MKNK11.94381239
19CASK1.81329198
20VRK11.77141723
21EIF2AK31.72394149
22MKNK21.71991638
23MAPK131.66996917
24NUAK11.66159818
25IRAK21.66125938
26PLK41.59075635
27CDC71.56923943
28TNIK1.54891522
29BRSK21.48575070
30TEC1.44538900
31MAP3K141.43919725
32BUB11.43293800
33ZAK1.42627887
34MAP3K121.42566910
35STK391.39149466
36TAF11.36713624
37NME11.33068362
38DYRK21.29841912
39BRAF1.29370267
40DYRK31.28614373
41CSNK1G31.27607356
42MST41.27539926
43EIF2AK21.25614695
44YES11.19494880
45BCKDK1.14986483
46WNK31.07805989
47WNK41.07039271
48MAPKAPK51.06882700
49IRAK11.05770222
50RPS6KA41.05695431
51NLK1.04636332
52EIF2AK11.01998098
53IKBKE1.00386938
54OXSR10.99772239
55CSNK1A1L0.99503987
56RPS6KA50.99401781
57NEK20.97910910
58BCR0.94349588
59PLK20.93866778
60INSRR0.93594241
61STK100.93401955
62BMPR1B0.92283497
63CDK190.91490341
64CCNB10.86730837
65STK38L0.84616389
66MAP4K20.84542823
67ACVR1B0.83418689
68CSNK1G20.81147606
69PNCK0.80438300
70KDR0.80002422
71AURKB0.79158886
72CSNK1G10.77884107
73AURKA0.76757692
74DAPK10.75138215
75ADRBK20.74578181
76MUSK0.74315011
77MAPKAPK30.73132364
78CAMK2B0.70307098
79PLK30.69505411
80TGFBR10.67783860
81ATR0.66488093
82BRSK10.65275815
83ABL20.63571852
84ATM0.61936240
85IKBKB0.61668086
86ILK0.60399450
87IRAK30.60383031
88CAMK2D0.59198259
89NME20.59025946
90RPS6KB10.58294358
91SYK0.58251421
92KIT0.57952146
93PRKCI0.57920635
94CDK30.56845206
95BTK0.56742629
96CLK10.56421509
97BLK0.56393799
98NEK60.56044467
99CHUK0.55285042
100CDK80.55111703
101WEE10.55016822
102CSNK2A10.54958720
103MAP2K60.54740491
104TLK10.54539325
105MARK30.54424927
106CHEK20.54305466
107LYN0.54119338
108STK30.52908153
109CSNK1E0.51170646
110LIMK10.50689366
111TTK0.50421821
112PINK10.49072571
113CAMK2G0.49039899
114PIM10.48544069
115ADRBK10.48219373
116PRPF4B0.48025138
117MAP3K40.47994842
118PLK10.47400232
119GRK70.47005550
120CHEK10.46919394
121FES0.46271737
122PRKCG0.44564518
123MAP3K60.43870480
124TBK10.43430319
125SIK20.43072808
126RAF10.42535624
127MARK10.42519804
128RPS6KB20.42040184
129PRKCE0.41207709
130TSSK60.41163895
131CSNK2A20.39680800
132TRPM70.39674748
133GRK50.39573062
134RIPK40.39384709
135MAPKAPK20.37061450
136PRKCD0.35710585
137CDK70.34731841
138MAPK150.32819083
139CSNK1A10.29041109
140ERBB40.28703829

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047446.08351037
2Olfactory transduction_Homo sapiens_hsa047403.05576855
3Proteasome_Homo sapiens_hsa030502.83497865
4DNA replication_Homo sapiens_hsa030302.57759812
5RNA polymerase_Homo sapiens_hsa030202.43974026
6Protein export_Homo sapiens_hsa030602.32657258
7Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.20492577
8Mismatch repair_Homo sapiens_hsa034302.18079990
9SNARE interactions in vesicular transport_Homo sapiens_hsa041302.05822440
10One carbon pool by folate_Homo sapiens_hsa006701.98940220
11Base excision repair_Homo sapiens_hsa034101.92462570
12Ribosome_Homo sapiens_hsa030101.91198250
13Homologous recombination_Homo sapiens_hsa034401.88399609
14Oxidative phosphorylation_Homo sapiens_hsa001901.79509467
15Spliceosome_Homo sapiens_hsa030401.74750821
16Parkinsons disease_Homo sapiens_hsa050121.65147170
17Graft-versus-host disease_Homo sapiens_hsa053321.64473805
18Pyrimidine metabolism_Homo sapiens_hsa002401.63473346
19Sulfur relay system_Homo sapiens_hsa041221.62330014
20Allograft rejection_Homo sapiens_hsa053301.58405206
21Sulfur metabolism_Homo sapiens_hsa009201.56179759
22Propanoate metabolism_Homo sapiens_hsa006401.55171804
23Nucleotide excision repair_Homo sapiens_hsa034201.53033987
24Huntingtons disease_Homo sapiens_hsa050161.44376701
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.43893702
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.41070400
27Basal transcription factors_Homo sapiens_hsa030221.38648876
28RNA degradation_Homo sapiens_hsa030181.35934077
29Cysteine and methionine metabolism_Homo sapiens_hsa002701.33594044
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.31167635
31Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.30979164
32RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.29659108
33Peroxisome_Homo sapiens_hsa041461.29181066
34Fatty acid elongation_Homo sapiens_hsa000621.26472675
35Purine metabolism_Homo sapiens_hsa002301.25916289
36Fanconi anemia pathway_Homo sapiens_hsa034601.19859633
37Pyruvate metabolism_Homo sapiens_hsa006201.16424189
38Steroid biosynthesis_Homo sapiens_hsa001001.16299640
39Alzheimers disease_Homo sapiens_hsa050101.15048986
40Selenocompound metabolism_Homo sapiens_hsa004501.14238990
41Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.11460005
42Glutathione metabolism_Homo sapiens_hsa004801.10329281
43Asthma_Homo sapiens_hsa053101.09629718
44Serotonergic synapse_Homo sapiens_hsa047261.07706961
45Pentose and glucuronate interconversions_Homo sapiens_hsa000401.06452213
46Cell cycle_Homo sapiens_hsa041101.06292159
47Drug metabolism - other enzymes_Homo sapiens_hsa009831.05521652
48Rheumatoid arthritis_Homo sapiens_hsa053231.03309364
49Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.01793879
50Caffeine metabolism_Homo sapiens_hsa002321.01224970
51Chemical carcinogenesis_Homo sapiens_hsa052040.99319159
52Intestinal immune network for IgA production_Homo sapiens_hsa046720.98426212
53Non-homologous end-joining_Homo sapiens_hsa034500.95517035
54Herpes simplex infection_Homo sapiens_hsa051680.94785064
55NF-kappa B signaling pathway_Homo sapiens_hsa040640.94719327
56Type I diabetes mellitus_Homo sapiens_hsa049400.93912519
57Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.93713018
58Butanoate metabolism_Homo sapiens_hsa006500.93437049
59Primary immunodeficiency_Homo sapiens_hsa053400.92705401
60Autoimmune thyroid disease_Homo sapiens_hsa053200.92567278
61Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.92217443
62Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.91695359
63beta-Alanine metabolism_Homo sapiens_hsa004100.90885857
64Measles_Homo sapiens_hsa051620.90700923
65Vibrio cholerae infection_Homo sapiens_hsa051100.90625773
66RNA transport_Homo sapiens_hsa030130.89999498
67Metabolic pathways_Homo sapiens_hsa011000.89912177
68Primary bile acid biosynthesis_Homo sapiens_hsa001200.88053402
69Fatty acid degradation_Homo sapiens_hsa000710.87751053
70Epstein-Barr virus infection_Homo sapiens_hsa051690.87021178
71Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.86254032
72Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.86234938
73Legionellosis_Homo sapiens_hsa051340.85650729
74Synaptic vesicle cycle_Homo sapiens_hsa047210.85217391
75Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.85075926
76Tryptophan metabolism_Homo sapiens_hsa003800.84909609
77Alcoholism_Homo sapiens_hsa050340.84279554
78Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.83312888
79Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.81976480
80Fatty acid metabolism_Homo sapiens_hsa012120.80943500
81Steroid hormone biosynthesis_Homo sapiens_hsa001400.80919438
82Phagosome_Homo sapiens_hsa041450.80910274
83Collecting duct acid secretion_Homo sapiens_hsa049660.79340903
84NOD-like receptor signaling pathway_Homo sapiens_hsa046210.78841317
85Cardiac muscle contraction_Homo sapiens_hsa042600.76346377
86Leishmaniasis_Homo sapiens_hsa051400.76029240
87Shigellosis_Homo sapiens_hsa051310.74198390
88Hematopoietic cell lineage_Homo sapiens_hsa046400.74197407
89Retinol metabolism_Homo sapiens_hsa008300.73173881
90Linoleic acid metabolism_Homo sapiens_hsa005910.72798828
91Morphine addiction_Homo sapiens_hsa050320.72194084
92mRNA surveillance pathway_Homo sapiens_hsa030150.71605628
93alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.71603522
94Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.71386239
95Maturity onset diabetes of the young_Homo sapiens_hsa049500.70678211
96Regulation of autophagy_Homo sapiens_hsa041400.68183430
97Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.66494763
98Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.66382100
99Vitamin B6 metabolism_Homo sapiens_hsa007500.65243826
100Phenylalanine metabolism_Homo sapiens_hsa003600.64148939
101Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.63951126
102Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.63038497
103Dopaminergic synapse_Homo sapiens_hsa047280.62582973
104Nitrogen metabolism_Homo sapiens_hsa009100.62275941
105Salmonella infection_Homo sapiens_hsa051320.61765938
106Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.61524164
107Circadian entrainment_Homo sapiens_hsa047130.61335797
108Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.60871007
109Arginine and proline metabolism_Homo sapiens_hsa003300.58745830
110Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.58665666
111Tyrosine metabolism_Homo sapiens_hsa003500.58437480
112Systemic lupus erythematosus_Homo sapiens_hsa053220.58425727
113Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.57747450
114Tuberculosis_Homo sapiens_hsa051520.57234987
115Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.57225642
116Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.56777202
117Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.56492487
118GABAergic synapse_Homo sapiens_hsa047270.55950072
119Taste transduction_Homo sapiens_hsa047420.55913874
120Pertussis_Homo sapiens_hsa051330.55882972
121Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.54262593
122Cholinergic synapse_Homo sapiens_hsa047250.53702533
123N-Glycan biosynthesis_Homo sapiens_hsa005100.53154635
124Toll-like receptor signaling pathway_Homo sapiens_hsa046200.51174455
125Chemokine signaling pathway_Homo sapiens_hsa040620.50551964
126Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.49646484
127Hepatitis B_Homo sapiens_hsa051610.48634834
128Glutamatergic synapse_Homo sapiens_hsa047240.47894639
129Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.47609199
130Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.47260770
131Influenza A_Homo sapiens_hsa051640.45522343
1322-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.45182376
133Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.44942258
134Folate biosynthesis_Homo sapiens_hsa007900.44101630
135Transcriptional misregulation in cancer_Homo sapiens_hsa052020.41707369
136Apoptosis_Homo sapiens_hsa042100.40683799
137Carbon metabolism_Homo sapiens_hsa012000.40213865
138p53 signaling pathway_Homo sapiens_hsa041150.39956965
139Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.38726060
140Ether lipid metabolism_Homo sapiens_hsa005650.38306785
141Antigen processing and presentation_Homo sapiens_hsa046120.38084634
142Malaria_Homo sapiens_hsa051440.37626813
143Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.35838896
144TNF signaling pathway_Homo sapiens_hsa046680.35075829
145T cell receptor signaling pathway_Homo sapiens_hsa046600.33864704
146Oocyte meiosis_Homo sapiens_hsa041140.33077155
147Arachidonic acid metabolism_Homo sapiens_hsa005900.32824702
148Fat digestion and absorption_Homo sapiens_hsa049750.32297039
149Sphingolipid metabolism_Homo sapiens_hsa006000.32190831
150Viral myocarditis_Homo sapiens_hsa054160.31303781
151Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.30318141
152Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.29396240
153Hepatitis C_Homo sapiens_hsa051600.29344232
154Fatty acid biosynthesis_Homo sapiens_hsa000610.22880854
155Mineral absorption_Homo sapiens_hsa049780.18494847

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