FAM101B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.49753436
2cellular extravasation (GO:0045123)5.42613808
3lymph vessel development (GO:0001945)5.07447795
4response to peptidoglycan (GO:0032494)4.98736042
5neutrophil activation involved in immune response (GO:0002283)4.83031331
6hemidesmosome assembly (GO:0031581)4.82218494
7detection of other organism (GO:0098543)4.56690205
8leukocyte aggregation (GO:0070486)4.51747321
9negative regulation of erythrocyte differentiation (GO:0045647)4.41691053
10regulation of B cell receptor signaling pathway (GO:0050855)4.39882419
11detection of bacterium (GO:0016045)4.35583065
12antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.34569181
13positive regulation of B cell differentiation (GO:0045579)4.32873371
14negative regulation of cell killing (GO:0031342)4.26945647
15negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.26945647
16vascular endothelial growth factor signaling pathway (GO:0038084)4.21999205
17modulation by symbiont of host defense response (GO:0052031)4.09933353
18modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.09933353
19modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.09933353
20positive regulation by organism of defense response of other organism involved in symbiotic interact4.09933353
21modulation by symbiont of host immune response (GO:0052553)4.09933353
22positive regulation by symbiont of host defense response (GO:0052509)4.09933353
23negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)4.02891621
24endodermal cell differentiation (GO:0035987)3.91998921
25neutrophil activation (GO:0042119)3.87719065
26leukocyte migration involved in inflammatory response (GO:0002523)3.86833965
27antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.83686714
28regulation of B cell differentiation (GO:0045577)3.83668432
29retina vasculature morphogenesis in camera-type eye (GO:0061299)3.82862600
30regulation of gamma-delta T cell differentiation (GO:0045586)3.81186843
31antigen processing and presentation of endogenous antigen (GO:0019883)3.80936402
32defense response to fungus (GO:0050832)3.79946146
33regulation of gamma-delta T cell activation (GO:0046643)3.79735467
34positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.77732342
35regulation of cardioblast differentiation (GO:0051890)3.74003461
36neutrophil mediated immunity (GO:0002446)3.73103240
37negative regulation of interleukin-12 production (GO:0032695)3.72283533
38response to host immune response (GO:0052572)3.71554214
39response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.71554214
40negative regulation of phagocytosis (GO:0050765)3.71184127
41collagen fibril organization (GO:0030199)3.70441138
42endocardial cushion morphogenesis (GO:0003203)3.66698657
43regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.64010315
44cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.61186678
45negative regulation of interleukin-8 production (GO:0032717)3.60418327
46granulocyte activation (GO:0036230)3.58977812
47negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.58912170
48negative regulation of cell fate specification (GO:0009996)3.58423504
49positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.55667677
50detection of external biotic stimulus (GO:0098581)3.54170733
51positive thymic T cell selection (GO:0045059)3.53427245
52epithelial cell-cell adhesion (GO:0090136)3.53257447
53response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.50004032
54response to host (GO:0075136)3.50004032
55response to host defenses (GO:0052200)3.50004032
56endothelial cell morphogenesis (GO:0001886)3.49819153
57positive regulation of granulocyte differentiation (GO:0030854)3.49673627
58bundle of His cell to Purkinje myocyte communication (GO:0086069)3.48837272
59respiratory burst (GO:0045730)3.47227146
60antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.43535103
61leukocyte degranulation (GO:0043299)3.42568489
62detection of biotic stimulus (GO:0009595)3.41226386
63atrioventricular valve morphogenesis (GO:0003181)3.40436363
64endothelium development (GO:0003158)3.36376423
65B cell receptor signaling pathway (GO:0050853)3.31064684
66hippo signaling (GO:0035329)3.31038949
67response to interleukin-15 (GO:0070672)3.30943929
68response to fungus (GO:0009620)3.30063031
69megakaryocyte development (GO:0035855)3.28587449
70trabecula formation (GO:0060343)3.27903266
71activated T cell proliferation (GO:0050798)3.26434796
72cell migration involved in sprouting angiogenesis (GO:0002042)3.26082646
73regulation of cardioblast proliferation (GO:0003264)3.25361680
74regulation of secondary heart field cardioblast proliferation (GO:0003266)3.25361680
75regulation of mast cell degranulation (GO:0043304)3.25170254
76heart trabecula formation (GO:0060347)3.24900272
77myeloid cell activation involved in immune response (GO:0002275)3.24393943
78response to muramyl dipeptide (GO:0032495)3.24150911
79cell-substrate junction assembly (GO:0007044)3.24111549
80antigen processing and presentation via MHC class Ib (GO:0002475)3.23926962
81mesenchyme morphogenesis (GO:0072132)3.23912658
82Arp2/3 complex-mediated actin nucleation (GO:0034314)3.23430054
83negative regulation of interleukin-6 production (GO:0032715)3.22796525
84pinocytosis (GO:0006907)3.20531415
85blood vessel endothelial cell migration (GO:0043534)3.20300757
86negative T cell selection (GO:0043383)3.18607848
87chondrocyte proliferation (GO:0035988)3.17019905
88negative thymic T cell selection (GO:0045060)3.15801975
89regulation of leukocyte degranulation (GO:0043300)3.15683940
90desmosome organization (GO:0002934)3.14677818
91regulation of somitogenesis (GO:0014807)3.14018736
92innate immune response in mucosa (GO:0002227)3.12757453
93positive regulation of epithelial to mesenchymal transition (GO:0010718)3.11389847
94negative regulation of fatty acid transport (GO:2000192)3.09272347
95collagen metabolic process (GO:0032963)3.08761882
96definitive hemopoiesis (GO:0060216)3.08083850
97regulation of myeloid leukocyte mediated immunity (GO:0002886)3.07678006
98negative regulation of T cell mediated immunity (GO:0002710)3.07654773
99endothelial tube morphogenesis (GO:0061154)3.07326918
100morphogenesis of an endothelium (GO:0003159)3.07326918
101macrophage activation involved in immune response (GO:0002281)3.05871944
102negative regulation of lymphocyte mediated immunity (GO:0002707)3.05601733
103heart valve morphogenesis (GO:0003179)3.05443038
104regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.05342368
105positive T cell selection (GO:0043368)3.04649939
106plasma membrane repair (GO:0001778)3.04501023
107regulation of tolerance induction (GO:0002643)3.00921741
108negative regulation of T-helper cell differentiation (GO:0045623)3.00781826
109negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.00781826
110interferon-gamma secretion (GO:0072643)2.98662171
111myeloid leukocyte mediated immunity (GO:0002444)2.97558804
112basement membrane organization (GO:0071711)2.97058534
113bone trabecula formation (GO:0060346)2.96440181
114endocrine hormone secretion (GO:0060986)2.95932237
115multicellular organismal macromolecule metabolic process (GO:0044259)2.94762903
116regulation of mast cell activation involved in immune response (GO:0033006)2.94250360
117protein heterotrimerization (GO:0070208)2.93870602
118positive regulation of interleukin-8 secretion (GO:2000484)2.93375160
119collagen catabolic process (GO:0030574)2.90942601
120negative regulation of leukocyte mediated immunity (GO:0002704)2.89722767
121detection of molecule of bacterial origin (GO:0032490)2.88357175
122cardiac right ventricle morphogenesis (GO:0003215)2.87242478
123vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.86763813
124renal filtration (GO:0097205)2.86392377
125regulation of transforming growth factor beta2 production (GO:0032909)2.86127243
126Notch signaling involved in heart development (GO:0061314)2.85560510
127cell adhesion mediated by integrin (GO:0033627)2.85386750
128regulation of heart morphogenesis (GO:2000826)2.83801308
129positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.83577370
130T cell selection (GO:0045058)2.82979428
131disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.82892043
132killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.82892043
133positive regulation of tolerance induction (GO:0002645)2.81925801
134tolerance induction (GO:0002507)2.81755446
135T cell migration (GO:0072678)2.81391300
136regulation of platelet aggregation (GO:0090330)2.81207148
137microglial cell activation (GO:0001774)2.81048540
138cellular response to interleukin-15 (GO:0071350)2.80743301
139positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.80486838
140regulation of T cell tolerance induction (GO:0002664)2.80432126
141multicellular organismal metabolic process (GO:0044236)2.80388079
142dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.79158659
143negative regulation of keratinocyte proliferation (GO:0010839)2.78891333
144regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.78570160
145multicellular organismal catabolic process (GO:0044243)2.78533318
146regulation of interferon-beta biosynthetic process (GO:0045357)2.78493614
147regulation of tight junction assembly (GO:2000810)2.78054538
148glomerular filtration (GO:0003094)2.77545122
149regulation of mast cell activation (GO:0033003)2.77225930
150substrate-dependent cell migration (GO:0006929)2.75273157
151organ or tissue specific immune response (GO:0002251)2.74317010
152thymic T cell selection (GO:0045061)2.73918714
153extracellular matrix disassembly (GO:0022617)2.73069065
154outflow tract septum morphogenesis (GO:0003148)2.72936661
155regulation of granulocyte differentiation (GO:0030852)2.72564724
156labyrinthine layer development (GO:0060711)2.72524474
157skin morphogenesis (GO:0043589)2.71598889
158endothelial cell differentiation (GO:0045446)2.71374747
159regulation of regulated secretory pathway (GO:1903305)2.71091818
160macrophage activation (GO:0042116)2.70606376
161mucosal immune response (GO:0002385)2.69856614
162immunoglobulin mediated immune response (GO:0016064)2.69359206
163epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.67509471
164regulation of vasculogenesis (GO:2001212)2.65361892
165aorta morphogenesis (GO:0035909)2.62706140
166coronary vasculature morphogenesis (GO:0060977)2.62076792
167regulation of cell fate specification (GO:0042659)2.61789740
168positive regulation of endothelial cell apoptotic process (GO:2000353)2.60846844
169response to fluid shear stress (GO:0034405)2.60664682
170sprouting angiogenesis (GO:0002040)2.59997878
171radial glial cell differentiation (GO:0060019)2.59769316
172patterning of blood vessels (GO:0001569)2.58329569
173regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.58301713
174negative regulation of cell fate commitment (GO:0010454)2.57872066
175pathway-restricted SMAD protein phosphorylation (GO:0060389)2.56405369
176lymphangiogenesis (GO:0001946)2.56119556
177cell surface receptor signaling pathway involved in heart development (GO:0061311)2.54971134
178cardiac muscle cell proliferation (GO:0060038)2.54936675
179heart valve formation (GO:0003188)2.54294072
180negative regulation of catenin import into nucleus (GO:0035414)2.53822600
181mammary gland development (GO:0030879)2.53616154
182surfactant homeostasis (GO:0043129)2.53158359
183axon extension involved in axon guidance (GO:0048846)2.52729680
184neuron projection extension involved in neuron projection guidance (GO:1902284)2.52729680
185sarcomere organization (GO:0045214)2.52225540
186mesenchymal cell development (GO:0014031)2.51927793
187cardiac epithelial to mesenchymal transition (GO:0060317)2.51763367
188regulation of G0 to G1 transition (GO:0070316)2.50249800
189positive regulation of stem cell differentiation (GO:2000738)2.50204674
190intestinal epithelial cell development (GO:0060576)2.49860909
191cellular response to vitamin D (GO:0071305)2.49681606
192cardiac ventricle morphogenesis (GO:0003208)2.48931138
193peptidyl-proline hydroxylation (GO:0019511)2.48127668
194protein localization to endosome (GO:0036010)2.47513774
195regulation of endothelial cell differentiation (GO:0045601)2.46164805
196growth hormone receptor signaling pathway (GO:0060396)2.44775202
197regulation of epithelial cell differentiation involved in kidney development (GO:2000696)2.44643055
198adherens junction assembly (GO:0034333)2.44026162
199protein localization to cell surface (GO:0034394)2.43837687
200mesodermal cell differentiation (GO:0048333)2.43572052

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human7.18114089
2TRIM28_21343339_ChIP-Seq_HEK293_Human6.01393837
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.73623361
4MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.74764714
5RARG_19884340_ChIP-ChIP_MEFs_Mouse3.69279169
6IRF8_22096565_ChIP-ChIP_GC-B_Human3.65253753
7VDR_21846776_ChIP-Seq_THP-1_Human3.51624256
8VDR_24763502_ChIP-Seq_THP-1_Human3.22888958
9TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.21330302
10TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.09366042
11SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.90307252
12SCL_19346495_ChIP-Seq_HPC-7_Human2.85770011
13CLOCK_20551151_ChIP-Seq_293T_Human2.81445895
14SPI1_23547873_ChIP-Seq_NB4_Human2.76162529
15MYC_22102868_ChIP-Seq_BL_Human2.71296421
16SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.68406975
17RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.62221971
18IRF8_21731497_ChIP-ChIP_J774_Mouse2.61929895
19NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.61455209
20NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.60666814
21MYB_26560356_Chip-Seq_TH2_Human2.55551091
22ZNF263_19887448_ChIP-Seq_K562_Human2.53802252
23IRF8_27001747_Chip-Seq_BMDM_Mouse2.51144536
24STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.46181607
25* BRD4_27068464_Chip-Seq_AML-cells_Mouse2.45779166
26ESR2_21235772_ChIP-Seq_MCF-7_Human2.41361998
27RUNX1_22412390_ChIP-Seq_EML_Mouse2.40146111
28MAF_26560356_Chip-Seq_TH1_Human2.38862103
29PPAR_26484153_Chip-Seq_NCI-H1993_Human2.36730987
30UTX_26944678_Chip-Seq_JUKART_Human2.33533395
31NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.28813468
32PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.26783575
33STAT4_19710469_ChIP-ChIP_TH1__Mouse2.26529120
34MYB_26560356_Chip-Seq_TH1_Human2.23968370
35ESR1_21235772_ChIP-Seq_MCF-7_Human2.22142358
36SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.21421664
37FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.19498159
38TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.08481970
39CDX2_19796622_ChIP-Seq_MESCs_Mouse2.08364237
40SPI1_23127762_ChIP-Seq_K562_Human2.06688245
41HIF1A_21447827_ChIP-Seq_MCF-7_Human2.04308121
42ELK3_25401928_ChIP-Seq_HUVEC_Human2.02471324
43ELF1_17652178_ChIP-ChIP_JURKAT_Human2.00127117
44STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.97172066
45FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.94226589
46EP300_21415370_ChIP-Seq_HL-1_Mouse1.92942415
47KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.90796605
48MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.90463681
49CJUN_26792858_Chip-Seq_BT549_Human1.86643705
50SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.86156306
51SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.85811443
52SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.85811443
53* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.85170090
54IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.81763612
55IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.81578033
56FOXO3_23340844_ChIP-Seq_DLD1_Human1.80561019
57ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.79969638
58VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.78937260
59GATA2_21666600_ChIP-Seq_HMVEC_Human1.78796570
60RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.78784075
61MAF_26560356_Chip-Seq_TH2_Human1.78274665
62EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.77284928
63E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.74363776
64KDM2B_26808549_Chip-Seq_SUP-B15_Human1.71403388
65SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.71301298
66* SOX2_20726797_ChIP-Seq_SW620_Human1.70917438
67RACK7_27058665_Chip-Seq_MCF-7_Human1.70260678
68TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.70124931
69Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.69910780
70STAT6_21828071_ChIP-Seq_BEAS2B_Human1.69571008
71VDR_24787735_ChIP-Seq_THP-1_Human1.68770805
72PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.67739145
73SALL4_18804426_ChIP-ChIP_XEN_Mouse1.67453556
74FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.67004396
75LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.63520488
76ZNF217_24962896_ChIP-Seq_MCF-7_Human1.62993424
77KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.62610071
78KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.62303563
79GATA2_22383799_ChIP-Seq_G1ME_Mouse1.61616927
80ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.60845028
81GATA1_22383799_ChIP-Seq_G1ME_Mouse1.60771620
82RUNX1_27514584_Chip-Seq_MCF-7_Human1.60189412
83WT1_19549856_ChIP-ChIP_CCG9911_Human1.59925781
84TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.58538899
85LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.55440964
86FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.55087607
87CDX2_20551321_ChIP-Seq_CACO-2_Human1.54708963
88E2F7_22180533_ChIP-Seq_HELA_Human1.54301093
89CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.51566267
90EGR1_19374776_ChIP-ChIP_THP-1_Human1.51308825
91PU_27001747_Chip-Seq_BMDM_Mouse1.49555262
92SMAD_19615063_ChIP-ChIP_OVARY_Human1.49160527
93BRD4_25478319_ChIP-Seq_HGPS_Human1.48888773
94GATA1_19941827_ChIP-Seq_MEL_Mouse1.48325514
95GATA1_22025678_ChIP-Seq_K562_Human1.48070567
96TBX20_22080862_ChIP-Seq_HEART_Mouse1.47571672
97TBX20_22328084_ChIP-Seq_HEART_Mouse1.47571672
98SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.45556318
99SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.44839610
100STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.44086486
101GATA3_27048872_Chip-Seq_THYMUS_Human1.43388618
102P300_27058665_Chip-Seq_ZR-75-30cells_Human1.39690960
103UBF1/2_26484160_Chip-Seq_HMECs_Human1.38837447
104WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.36755152
105ATF3_27146783_Chip-Seq_COLON_Human1.36270232
106ESR1_20079471_ChIP-ChIP_T-47D_Human1.35416604
107GATA1_19941826_ChIP-Seq_K562_Human1.34976043
108GATA4_25053715_ChIP-Seq_YYC3_Human1.34441753
109TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.33949437
110CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.33597111
111SOX2_27498859_Chip-Seq_STOMACH_Mouse1.33513040
112STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.32521920
113AHR_22903824_ChIP-Seq_MCF-7_Human1.32394423
114NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.31383098
115JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.31379510
116PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.30948323
117GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.29432079
118PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.29406537
119KLF5_25053715_ChIP-Seq_YYC3_Human1.28393080
120TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.28249050
121GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.28227481
122CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.28019177
123ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.27226363
124TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.27185908
125SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.26683970
126FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.26025921
127CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.25741054
128RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.22661194
129KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.22256719
130UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.21435293
131JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.21085449
132GATA3_24758297_ChIP-Seq_MCF-7_Human1.20278297
133KDM2B_26808549_Chip-Seq_DND41_Human1.20208783
134GATA3_26560356_Chip-Seq_TH2_Human1.18695437
135CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.17870458
136TCF4_18268006_ChIP-ChIP_LS174T_Human1.17528966
137ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.16588950
138P63_26484246_Chip-Seq_KERATINOCYTES_Human1.15225852
139EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.12040618
140MYB_21317192_ChIP-Seq_ERMYB_Mouse1.10173080
141NCOR1_26117541_ChIP-Seq_K562_Human1.08767544
142RXR_22108803_ChIP-Seq_LS180_Human1.07887553
143CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.07853804
144KDM2B_26808549_Chip-Seq_K562_Human1.07730136
145PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.07279389
146GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06478965
147EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.06423134
148RUNX_20019798_ChIP-Seq_JUKART_Human1.05707591
149PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.05534061
150GATA2_19941826_ChIP-Seq_K562_Human1.05519565
151CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.05328101
152ISL1_27105846_Chip-Seq_CPCs_Mouse1.05149145
153ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.04508739
154KDM2B_26808549_Chip-Seq_JURKAT_Human1.03650404
155TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.03085256
156* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02532226
157SMC1_22415368_ChIP-Seq_MEFs_Mouse1.01104636
158LXR_22292898_ChIP-Seq_THP-1_Human1.00719063
159ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.00649067
160PU.1_20513432_ChIP-Seq_Bcells_Mouse1.00472442
161NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.00111959
162TFEB_21752829_ChIP-Seq_HELA_Human0.99509099
163GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.99086429
164CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.98509186
165RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.98387676
166CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96642214
167CTCF_27219007_Chip-Seq_ERYTHROID_Human0.95416120
168GATA6_25053715_ChIP-Seq_YYC3_Human0.95239388
169HOXB4_20404135_ChIP-ChIP_EML_Mouse0.94254470
170NRF2_20460467_ChIP-Seq_MEFs_Mouse0.94095291
171NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.94095291
172KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.93316962
173KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.93316962
174KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.93316962
175TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.91988520
176TP53_20018659_ChIP-ChIP_R1E_Mouse0.91027175
177SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.90985768
178ARNT_22903824_ChIP-Seq_MCF-7_Human0.90375104
179DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.89442340
180TCF7_22412390_ChIP-Seq_EML_Mouse0.88712000

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.04141566
2MP0003436_decreased_susceptibility_to3.61567751
3MP0004272_abnormal_basement_membrane3.29909455
4MP0003705_abnormal_hypodermis_morpholog3.11388415
5MP0001835_abnormal_antigen_presentation3.03056469
6MP0005275_abnormal_skin_tensile3.02702713
7MP0002419_abnormal_innate_immunity2.78031677
8MP0005464_abnormal_platelet_physiology2.77557351
9MP0005377_hearing/vestibular/ear_phenot2.75786346
10MP0003878_abnormal_ear_physiology2.75786346
11MP0002396_abnormal_hematopoietic_system2.70100980
12MP0003763_abnormal_thymus_physiology2.52018564
13MP0003279_aneurysm2.46394638
14MP0003566_abnormal_cell_adhesion2.43990851
15MP0005025_abnormal_response_to2.43966179
16MP0009785_altered_susceptibility_to2.26794290
17MP0005000_abnormal_immune_tolerance2.26719949
18MP0005503_abnormal_tendon_morphology2.26234725
19MP0002420_abnormal_adaptive_immunity2.24523869
20MP0010234_abnormal_vibrissa_follicle2.23246021
21MP0001819_abnormal_immune_cell2.21677252
22MP0001800_abnormal_humoral_immune2.19342704
23MP0003172_abnormal_lysosome_physiology2.14323696
24MP0010368_abnormal_lymphatic_system2.14003957
25MP0003828_pulmonary_edema2.13726387
26MP0005671_abnormal_response_to2.12636813
27MP0000685_abnormal_immune_system2.10074136
28MP0001879_abnormal_lymphatic_vessel2.09353597
29MP0006054_spinal_hemorrhage2.06426878
30MP0004084_abnormal_cardiac_muscle2.05987079
31MP0002398_abnormal_bone_marrow2.05452077
32MP0002723_abnormal_immune_serum2.05140408
33MP0000015_abnormal_ear_pigmentation2.03528760
34MP0002452_abnormal_antigen_presenting2.03517308
35MP0005623_abnormal_meninges_morphology2.02837742
36MP0003941_abnormal_skin_development1.99902360
37MP0009384_cardiac_valve_regurgitation1.98080682
38MP0001958_emphysema1.96300160
39MP0002148_abnormal_hypersensitivity_rea1.87488969
40MP0005387_immune_system_phenotype1.83606656
41MP0001790_abnormal_immune_system1.83606656
42MP0010352_gastrointestinal_tract_polyps1.83582710
43MP0005167_abnormal_blood-brain_barrier1.83224114
44MP0002060_abnormal_skin_morphology1.82712357
45MP0006082_CNS_inflammation1.78683656
46MP0002405_respiratory_system_inflammati1.78146368
47MP0000716_abnormal_immune_system1.76944603
48MP0009333_abnormal_splenocyte_physiolog1.71864007
49MP0000703_abnormal_thymus_morphology1.71006811
50MP0002722_abnormal_immune_system1.70793447
51MP0000689_abnormal_spleen_morphology1.66507972
52MP0003300_gastrointestinal_ulcer1.65012315
53MP0002837_dystrophic_cardiac_calcinosis1.62518117
54MP0000465_gastrointestinal_hemorrhage1.58884059
55MP0009278_abnormal_bone_marrow1.58459177
56MP0002429_abnormal_blood_cell1.57767336
57MP0005508_abnormal_skeleton_morphology1.56141917
58MP0005075_abnormal_melanosome_morpholog1.54451432
59MP0006138_congestive_heart_failure1.53844400
60MP0008260_abnormal_autophagy1.53190597
61MP0003191_abnormal_cellular_cholesterol1.53077619
62MP0005023_abnormal_wound_healing1.51414969
63MP0005397_hematopoietic_system_phenotyp1.49475983
64MP0001545_abnormal_hematopoietic_system1.49475983
65MP0001851_eye_inflammation1.48483990
66MP0004484_altered_response_of1.47461429
67MP0000013_abnormal_adipose_tissue1.46491854
68MP0002166_altered_tumor_susceptibility1.43639921
69MP0004947_skin_inflammation1.43049253
70MP0008004_abnormal_stomach_pH1.40442491
71MP0005058_abnormal_lysosome_morphology1.40299059
72MP0002009_preneoplasia1.39804494
73MP0004381_abnormal_hair_follicle1.38985140
74MP0001845_abnormal_inflammatory_respons1.38185511
75MP0010030_abnormal_orbit_morphology1.37926039
76MP0010155_abnormal_intestine_physiology1.35911709
77MP0004215_abnormal_myocardial_fiber1.33790937
78MP0002132_abnormal_respiratory_system1.33208744
79MP0002998_abnormal_bone_remodeling1.30703754
80MP0003091_abnormal_cell_migration1.27753619
81MP0000858_altered_metastatic_potential1.25538634
82MP0003879_abnormal_hair_cell1.25185228
83MP0000762_abnormal_tongue_morphology1.23769015
84MP0000733_abnormal_muscle_development1.23277034
85MP0005174_abnormal_tail_pigmentation1.23020385
86MP0010630_abnormal_cardiac_muscle1.22315246
87MP0005385_cardiovascular_system_phenoty1.20789292
88MP0001544_abnormal_cardiovascular_syste1.20789292
89MP0005330_cardiomyopathy1.18858069
90MP0000767_abnormal_smooth_muscle1.16751295
91MP0002896_abnormal_bone_mineralization1.16127939
92MP0003866_abnormal_defecation1.15193634
93MP0002972_abnormal_cardiac_muscle1.13639577
94MP0010678_abnormal_skin_adnexa1.12866809
95MP0004185_abnormal_adipocyte_glucose1.11782040
96MP0002295_abnormal_pulmonary_circulatio1.10244812
97MP0001853_heart_inflammation1.09942250
98MP0002796_impaired_skin_barrier1.09693367
99MP0009053_abnormal_anal_canal1.09046314
100MP0003656_abnormal_erythrocyte_physiolo1.08868088
101MP0000003_abnormal_adipose_tissue1.08523091
102MP0000537_abnormal_urethra_morphology1.07802892
103MP0000383_abnormal_hair_follicle1.06660322
104MP0004883_abnormal_blood_vessel1.05252962
105MP0009764_decreased_sensitivity_to1.04092240
106MP0002925_abnormal_cardiovascular_devel1.03965429
107MP0009250_abnormal_appendicular_skeleto1.03791738
108MP0002282_abnormal_trachea_morphology1.02479168
109MP0008469_abnormal_protein_level1.02040318
110MP0000751_myopathy1.01558601
111MP0001346_abnormal_lacrimal_gland1.01302692
112MP0005367_renal/urinary_system_phenotyp1.01126843
113MP0000516_abnormal_urinary_system1.01126843
114MP0005390_skeleton_phenotype0.99676997
115MP0005076_abnormal_cell_differentiation0.96671470
116MP0004087_abnormal_muscle_fiber0.95880321
117MP0002098_abnormal_vibrissa_morphology0.95443314
118MP0005670_abnormal_white_adipose0.95422586
119MP0005164_abnormal_response_to0.94188158
120MP0002006_tumorigenesis0.93316066
121MP0000372_irregular_coat_pigmentation0.92640185
122MP0002932_abnormal_joint_morphology0.92571024
123MP0002108_abnormal_muscle_morphology0.92342252
124MP0005409_darkened_coat_color0.92291823
125MP0003303_peritoneal_inflammation0.91861025
126MP0001849_ear_inflammation0.91715833
127MP0002933_joint_inflammation0.91684942
128MP0002877_abnormal_melanocyte_morpholog0.91679060
129MP0005375_adipose_tissue_phenotype0.91624253
130MP0000163_abnormal_cartilage_morphology0.91191050
131MP0003453_abnormal_keratinocyte_physiol0.91115607
132MP0005666_abnormal_adipose_tissue0.90991983
133MP0004808_abnormal_hematopoietic_stem0.89453513
134MP0000428_abnormal_craniofacial_morphol0.88932926
135MP0000049_abnormal_middle_ear0.88440374
136MP0000750_abnormal_muscle_regeneration0.87920860
137MP0003045_fibrosis0.86956256
138MP0003935_abnormal_craniofacial_develop0.86638743
139MP0001614_abnormal_blood_vessel0.86525181
140MP0000534_abnormal_ureter_morphology0.86038073
141MP0002128_abnormal_blood_circulation0.85527199
142MP0000371_diluted_coat_color0.83894907
143MP0009763_increased_sensitivity_to0.83050022
144MP0002127_abnormal_cardiovascular_syste0.81567101
145MP0000490_abnormal_crypts_of0.81465378
146MP0002019_abnormal_tumor_incidence0.81139304
147MP0005620_abnormal_muscle_contractility0.81124248
148MP0003795_abnormal_bone_structure0.80608544
149MP0004264_abnormal_extraembryonic_tissu0.80567363
150MP0002115_abnormal_skeleton_extremities0.80252742
151MP0003448_altered_tumor_morphology0.80143606
152MP0003806_abnormal_nucleotide_metabolis0.79225066
153MP0001542_abnormal_bone_strength0.78869696
154MP0003075_altered_response_to0.78543595
155MP0002234_abnormal_pharynx_morphology0.78164042
156MP0001533_abnormal_skeleton_physiology0.77967901
157MP0000569_abnormal_digit_pigmentation0.77686333
158MP0003950_abnormal_plasma_membrane0.77681504
159MP0001216_abnormal_epidermal_layer0.77279996
160MP0002089_abnormal_postnatal_growth/wei0.76995423
161MP0005451_abnormal_body_composition0.76755818
162MP0000266_abnormal_heart_morphology0.76576331
163MP0000249_abnormal_blood_vessel0.76349077
164MP0003115_abnormal_respiratory_system0.75184670
165MP0002138_abnormal_hepatobiliary_system0.74984399
166MP0000377_abnormal_hair_follicle0.74871303
167MP0001873_stomach_inflammation0.74640205
168MP0003755_abnormal_palate_morphology0.73914187
169MP0003567_abnormal_fetal_cardiomyocyte0.73900324
170MP0001915_intracranial_hemorrhage0.73632026
171MP0001784_abnormal_fluid_regulation0.73087903
172MP0003724_increased_susceptibility_to0.72985654
173MP0000343_altered_response_to0.71817650
174MP0001663_abnormal_digestive_system0.71351585
175MP0002095_abnormal_skin_pigmentation0.67144972
176MP0009765_abnormal_xenobiotic_induced0.66432628
177MP0005310_abnormal_salivary_gland0.65962583

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)5.63646848
2Eczematoid dermatitis (HP:0000976)4.84811397
3Recurrent abscess formation (HP:0002722)4.79788140
4Protrusio acetabuli (HP:0003179)4.75080242
5Recurrent bacterial skin infections (HP:0005406)4.46422605
6Abnormal delayed hypersensitivity skin test (HP:0002963)4.30692796
7Myositis (HP:0100614)4.26680221
8Atrophic scars (HP:0001075)4.26200887
9Right ventricular cardiomyopathy (HP:0011663)4.25910231
10Elevated erythrocyte sedimentation rate (HP:0003565)4.19597576
11Stomatitis (HP:0010280)4.12665924
12Prolonged bleeding time (HP:0003010)3.93811622
13Abnormality of macrophages (HP:0004311)3.85693431
14Shallow orbits (HP:0000586)3.74040877
15Recurrent fungal infections (HP:0002841)3.69649243
16Obstructive lung disease (HP:0006536)3.68294629
17Chronic obstructive pulmonary disease (HP:0006510)3.68294629
18Aortic dissection (HP:0002647)3.63217744
19Broad metatarsal (HP:0001783)3.63115740
20Epistaxis (HP:0000421)3.45853191
21Spontaneous hematomas (HP:0007420)3.45334867
22Orchitis (HP:0100796)3.42834978
23Chronic mucocutaneous candidiasis (HP:0002728)3.36636907
24Recurrent cutaneous fungal infections (HP:0011370)3.36636907
25Recurrent skin infections (HP:0001581)3.34125406
26Muscle fiber splitting (HP:0003555)3.33668754
27Gastrointestinal infarctions (HP:0005244)3.29337553
28Increased connective tissue (HP:0009025)3.27544961
29Cerebral aneurysm (HP:0004944)3.25590788
30Epiphyseal dysplasia (HP:0002656)3.24656209
31Meningitis (HP:0001287)3.23722569
32Hypochromic microcytic anemia (HP:0004840)3.19806663
33Chest pain (HP:0100749)3.19045029
34Mediastinal lymphadenopathy (HP:0100721)3.17646846
35Recurrent gram-negative bacterial infections (HP:0005420)3.15091902
36Optic neuritis (HP:0100653)3.12245143
37Retrobulbar optic neuritis (HP:0100654)3.12245143
38Hypoplastic ischia (HP:0003175)3.08991981
39Aortic aneurysm (HP:0004942)3.08919497
40Fragile skin (HP:0001030)3.04544486
41Granulocytopenia (HP:0001913)3.02462861
42Ankle contracture (HP:0006466)3.01408750
43Unilateral renal agenesis (HP:0000122)2.99484547
44Dilatation of the ascending aorta (HP:0005111)2.95571099
45Abnormal platelet volume (HP:0011876)2.95285020
46Abnormality of T cell number (HP:0011839)2.94854311
47Hypochromic anemia (HP:0001931)2.93511537
48Alopecia of scalp (HP:0002293)2.92292166
49T lymphocytopenia (HP:0005403)2.90611585
50Recurrent viral infections (HP:0004429)2.90572016
51Petechiae (HP:0000967)2.89909762
52Gingival bleeding (HP:0000225)2.86838915
53Cellulitis (HP:0100658)2.85562415
54Gingivitis (HP:0000230)2.79954114
55Neonatal short-limb short stature (HP:0008921)2.79769643
56Abnormal vertebral ossification (HP:0100569)2.79758214
57Autoimmune hemolytic anemia (HP:0001890)2.78924182
58Ventricular tachycardia (HP:0004756)2.78338767
59Pulmonary infiltrates (HP:0002113)2.78032518
60Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.75523963
61Spondylolisthesis (HP:0003302)2.74700706
62Abnormality of T cells (HP:0002843)2.74253316
63Leukocytosis (HP:0001974)2.73760174
64Urticaria (HP:0001025)2.70514227
65Abnormality of T cell physiology (HP:0011840)2.70230537
66Arterial thrombosis (HP:0004420)2.70182565
67Cervical subluxation (HP:0003308)2.67923598
68Mitral valve prolapse (HP:0001634)2.67609622
69Ocular albinism (HP:0001107)2.67204739
70Increased IgE level (HP:0003212)2.67188233
71Encephalitis (HP:0002383)2.66386262
72Vasculitis (HP:0002633)2.65262549
73Hemoptysis (HP:0002105)2.65232202
74Abnormality of the ischium (HP:0003174)2.63993050
75Onycholysis (HP:0001806)2.63249710
76Difficulty climbing stairs (HP:0003551)2.62718490
77Thrombocytosis (HP:0001894)2.59840560
78Abnormality of the distal phalanges of the toes (HP:0010182)2.55542176
79Mixed hearing impairment (HP:0000410)2.50587013
80Eosinophilia (HP:0001880)2.50303296
81Autoimmune thrombocytopenia (HP:0001973)2.45884708
82Milia (HP:0001056)2.44871700
83Thin bony cortex (HP:0002753)2.40319019
84Increased mean platelet volume (HP:0011877)2.38033841
85Soft skin (HP:0000977)2.37831176
86Vascular tortuosity (HP:0004948)2.37259660
87Fused cervical vertebrae (HP:0002949)2.34695436
88Keratoconjunctivitis sicca (HP:0001097)2.33510001
89Episodic fever (HP:0001954)2.31991374
90Microcytic anemia (HP:0001935)2.30715984
91Panhypogammaglobulinemia (HP:0003139)2.30364501
92Pustule (HP:0200039)2.29857509
93Ileus (HP:0002595)2.29443171
94Abnormality of the heme biosynthetic pathway (HP:0010472)2.27548874
95Rectal prolapse (HP:0002035)2.26834964
96Amyloidosis (HP:0011034)2.25777686
97Follicular hyperkeratosis (HP:0007502)2.25395679
98Pulmonary embolism (HP:0002204)2.24014237
99Spinal rigidity (HP:0003306)2.23175638
100Abnormal platelet function (HP:0011869)2.20044842
101Impaired platelet aggregation (HP:0003540)2.20044842
102Fragile nails (HP:0001808)2.18427895
103Iris hypopigmentation (HP:0007730)2.17880937
104Platyspondyly (HP:0000926)2.15391454
105Osteomyelitis (HP:0002754)2.13271921
106Arterial tortuosity (HP:0005116)2.12096505
107Genu recurvatum (HP:0002816)2.11680044
108Increased IgM level (HP:0003496)2.11445085
109Hepatosplenomegaly (HP:0001433)2.10880740
110Short nail (HP:0001799)2.10085844
111Fatigue (HP:0012378)2.10077033
112Keratoconjunctivitis (HP:0001096)2.10036731
113Blue sclerae (HP:0000592)2.08506403
114Mitral regurgitation (HP:0001653)2.05716944
115Mesomelia (HP:0003027)2.04122839
116Glomerulopathy (HP:0100820)2.03457888
117Peritonitis (HP:0002586)2.02828936
118Hypergammaglobulinemia (HP:0010702)2.02604480
119Aneurysm (HP:0002617)2.00716565
120Nonimmune hydrops fetalis (HP:0001790)2.00660619
121Wide anterior fontanel (HP:0000260)1.99898595
122Abnormality of the peritoneum (HP:0002585)1.99793045
123Osteolytic defects of the hand bones (HP:0009699)1.99768480
124Osteolytic defects of the phalanges of the hand (HP:0009771)1.99768480
125Abnormality of dentin (HP:0010299)1.99416819
126Abnormality of the prostate (HP:0008775)1.98932474
127Anorexia (HP:0002039)1.98716364
128Wormian bones (HP:0002645)1.98630405
129Mildly elevated creatine phosphokinase (HP:0008180)1.98596917
130Pili torti (HP:0003777)1.98217027
131Inflammation of the large intestine (HP:0002037)1.97890610
132Myocardial infarction (HP:0001658)1.97031625
133Gastrointestinal inflammation (HP:0004386)1.96434820
134Abnormality of cells of the lymphoid lineage (HP:0012140)1.95803659
135Bicuspid aortic valve (HP:0001647)1.95190055
136Bladder diverticulum (HP:0000015)1.95111366
137Skin ulcer (HP:0200042)1.94868547
138Congenital, generalized hypertrichosis (HP:0004540)1.94853911
139Distal lower limb muscle weakness (HP:0009053)1.94403356
140Abnormality of eosinophils (HP:0001879)1.94328055
141Wrist flexion contracture (HP:0001239)1.94034524
142Lipoatrophy (HP:0100578)1.92793158
143Difficulty running (HP:0009046)1.92492548
144Spinal cord lesions (HP:0100561)1.91911415
145Syringomyelia (HP:0003396)1.91911415
146Knee flexion contracture (HP:0006380)1.90016021
147Lymphopenia (HP:0001888)1.88635412
148Thrombophlebitis (HP:0004418)1.88531194
149Hypoplasia of the iris (HP:0007676)1.88053934
150Viral hepatitis (HP:0006562)1.87875428
151Elbow flexion contracture (HP:0002987)1.85463573
152Purpura (HP:0000979)1.85086130
153Bruising susceptibility (HP:0000978)1.84648189
154Amaurosis fugax (HP:0100576)1.83610835
155Severe Myopia (HP:0011003)1.83279417
156Glossoptosis (HP:0000162)1.82906876
157Polygenic inheritance (HP:0010982)1.82663926
158Short hallux (HP:0010109)1.81664333
159Thoracolumbar scoliosis (HP:0002944)1.81385798
160Hematochezia (HP:0002573)1.81117889
161Scapular winging (HP:0003691)1.80287761
162Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.80249366
163Short 4th metacarpal (HP:0010044)1.80249366
164Osteoarthritis (HP:0002758)1.79752956
165Type 1 muscle fiber predominance (HP:0003803)1.79441840
166Hip contracture (HP:0003273)1.79059330
167Exostoses (HP:0100777)1.78316512
168Broad ribs (HP:0000885)1.77323530
169Bell-shaped thorax (HP:0001591)1.75401905
170Increased variability in muscle fiber diameter (HP:0003557)1.73901995
171Sudden death (HP:0001699)1.73693298
172Acanthosis nigricans (HP:0000956)1.72130789
173Reduced subcutaneous adipose tissue (HP:0003758)1.71761566
174Aplasia/Hypoplasia of the hallux (HP:0008362)1.69916726
175Flat acetabular roof (HP:0003180)1.69529851
176Pterygium (HP:0001059)1.69010788
177Hyporeflexia of lower limbs (HP:0002600)1.68595520
178Down-sloping shoulders (HP:0200021)1.68235079
179Venous abnormality (HP:0002624)1.67832768
180Abnormality of the 4th metacarpal (HP:0010012)1.65763268
181Polycythemia (HP:0001901)1.65706683
182Atrial fibrillation (HP:0005110)1.65047793
183Overgrowth (HP:0001548)1.64436333
184Sprengel anomaly (HP:0000912)1.63949019
185Hyperextensible skin (HP:0000974)1.63771033
186Bundle branch block (HP:0011710)1.61214951
187Abnormality of skeletal muscle fiber size (HP:0012084)1.61188211
188Absent eyelashes (HP:0000561)1.57804468
189Spinal cord compression (HP:0002176)1.57637154

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR24.41155282
2RIPK43.85071052
3TTN3.62314595
4TRIB33.59640632
5TIE13.54398611
6EPHA23.45491569
7KDR3.17163465
8PRPF4B3.15947040
9FES3.09601671
10MAP4K12.90064244
11RIPK12.74900294
12TXK2.60525902
13TRPM72.41293837
14ZAP702.37532998
15EPHB22.31989699
16MAP3K32.31222610
17LATS12.14912613
18TYK22.07346810
19KIT2.05056474
20PKN22.04169628
21FRK2.02239679
22BTK1.97560005
23EPHB11.95641598
24MYLK1.92429722
25PTK61.88136094
26TGFBR21.86324504
27MAP3K141.84573523
28PAK41.78588154
29NUAK11.72562483
30SYK1.68742352
31BLK1.65126910
32PRKG21.63092970
33PDGFRA1.61396385
34JAK31.60738107
35DMPK1.60622332
36SMG11.60232847
37HCK1.60078231
38PIK3CG1.59406904
39LMTK21.54297469
40PTK21.53974637
41FER1.52283719
42MAP2K21.46414506
43SIK11.46218269
44TNK21.44950282
45PAK31.41922838
46LRRK21.41187102
47MAP2K31.38842009
48TAOK21.35070031
49MAP3K131.33056076
50PDK21.31231780
51EPHA31.27302825
52FGFR31.24530569
53MAP3K111.20821791
54NLK1.20646039
55TBK11.20370438
56MAP3K61.19458850
57LYN1.17830128
58MAP3K11.14384396
59TESK21.13034492
60LCK1.11381658
61ILK1.10024134
62PTK2B1.08926730
63CDK121.05832369
64ERBB31.03728529
65IRAK11.01914913
66STK30.98299303
67STK100.97056209
68PIK3CA0.96943897
69STK38L0.96810300
70FGFR10.96110930
71TAOK10.95051278
72NEK90.94915319
73ITK0.93549322
74IKBKE0.93499850
75JAK20.93488714
76MARK30.92433364
77ZAK0.89933418
78TAOK30.89267651
79FGFR20.88840495
80CSF1R0.88535827
81SIK30.88419226
82FGFR40.87409889
83JAK10.86598691
84TGFBR10.85332307
85FGR0.84677660
86FLT30.83580827
87MAP2K10.81635917
88KSR20.79916165
89YES10.79786015
90BMPR20.78125822
91IRAK20.77969161
92MAPK120.75990850
93IKBKB0.74980681
94AKT30.72752594
95HIPK20.71600299
96NME20.71450602
97PDK10.69032711
98CSK0.68424695
99PDGFRB0.66137175
100TESK10.64366182
101RPS6KB20.64345435
102RPS6KA40.63177903
103STK240.63175776
104CDK40.62884391
105PRKD10.61601370
106EEF2K0.61099118
107CDK60.60903882
108MOS0.60400874
109DYRK1B0.60056492
110RPS6KC10.59328039
111RPS6KL10.59328039
112MAPK70.59084256
113PRKCQ0.58128549
114MST40.55856116
115MST1R0.55196815
116PRKCH0.54790941
117MAP3K20.54303237
118PAK20.53569049
119PIM10.52987277
120MATK0.52574383
121PDK40.50861774
122PDK30.50861774
123MARK20.50769992
124PRKAA20.50200820
125ROCK10.50199405
126ERN10.50191865
127MAP3K50.47632195
128RPS6KA60.47564904
129CAMK1D0.47134014
130MAP3K80.46612648
131LATS20.46496326
132PIM20.46037297
133CLK10.43104345
134PRKCI0.42974263
135TEC0.42214194
136PRKD20.40649348
137FYN0.40193243
138GRK60.39896199
139MAP3K100.38848353
140MAP3K70.36830210
141MTOR0.36512216
142GRK70.35595831
143CDK190.35541666
144PDPK10.35230073
145IRAK40.34214851
146RET0.33435512
147RPS6KA20.33079104
148GRK10.32691291
149MAPK40.32128225
150MET0.31830287
151MAPK110.30977664
152MELK0.30016353
153IRAK30.29768147
154STK380.29520385
155IGF1R0.29460983
156GSK3A0.28499615
157ROCK20.28178503
158PRKCE0.28152013
159NEK20.25996399
160MAPKAPK20.25709938

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045122.94225277
2Adherens junction_Homo sapiens_hsa045202.64831283
3Focal adhesion_Homo sapiens_hsa045102.58864756
4Leukocyte transendothelial migration_Homo sapiens_hsa046702.47975854
5B cell receptor signaling pathway_Homo sapiens_hsa046622.15221391
6Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.14207358
7Hippo signaling pathway_Homo sapiens_hsa043902.09746789
8Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.09347288
9Protein digestion and absorption_Homo sapiens_hsa049742.02262819
10Proteoglycans in cancer_Homo sapiens_hsa052051.95068245
11Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.94383380
12AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.94357174
13Tight junction_Homo sapiens_hsa045301.89797813
14T cell receptor signaling pathway_Homo sapiens_hsa046601.88886445
15Primary immunodeficiency_Homo sapiens_hsa053401.88714814
16Small cell lung cancer_Homo sapiens_hsa052221.85424018
17Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.83920943
18Dilated cardiomyopathy_Homo sapiens_hsa054141.81030793
19Measles_Homo sapiens_hsa051621.77225776
20Hematopoietic cell lineage_Homo sapiens_hsa046401.75007815
21NOD-like receptor signaling pathway_Homo sapiens_hsa046211.71735047
22Non-small cell lung cancer_Homo sapiens_hsa052231.71534668
23Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.70195875
24Toll-like receptor signaling pathway_Homo sapiens_hsa046201.62947822
25Amoebiasis_Homo sapiens_hsa051461.60569677
26TGF-beta signaling pathway_Homo sapiens_hsa043501.60288229
27Basal cell carcinoma_Homo sapiens_hsa052171.56760570
28Tuberculosis_Homo sapiens_hsa051521.54854764
29Other glycan degradation_Homo sapiens_hsa005111.51080538
30NF-kappa B signaling pathway_Homo sapiens_hsa040641.50360993
31Graft-versus-host disease_Homo sapiens_hsa053321.49660245
32Staphylococcus aureus infection_Homo sapiens_hsa051501.47336128
33Autoimmune thyroid disease_Homo sapiens_hsa053201.46831258
34Allograft rejection_Homo sapiens_hsa053301.44469614
35Chemokine signaling pathway_Homo sapiens_hsa040621.43284619
36Viral myocarditis_Homo sapiens_hsa054161.43072516
37Bladder cancer_Homo sapiens_hsa052191.42362768
38Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.40036181
39Chronic myeloid leukemia_Homo sapiens_hsa052201.36385101
40Notch signaling pathway_Homo sapiens_hsa043301.34427315
41RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.32999059
42Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.32503623
43Influenza A_Homo sapiens_hsa051641.29938149
44Toxoplasmosis_Homo sapiens_hsa051451.29413036
45Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.27588185
46Rap1 signaling pathway_Homo sapiens_hsa040151.27457482
47Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.26866868
48Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.26645322
49Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.24593131
50Platelet activation_Homo sapiens_hsa046111.23407567
51Renal cell carcinoma_Homo sapiens_hsa052111.23308095
52Legionellosis_Homo sapiens_hsa051341.22399998
53Regulation of actin cytoskeleton_Homo sapiens_hsa048101.22199625
54Herpes simplex infection_Homo sapiens_hsa051681.20930478
55African trypanosomiasis_Homo sapiens_hsa051431.17426935
56Pathways in cancer_Homo sapiens_hsa052001.17392986
57Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.17322878
58Prostate cancer_Homo sapiens_hsa052151.15267667
59Insulin resistance_Homo sapiens_hsa049311.14877808
60Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.13130395
61MicroRNAs in cancer_Homo sapiens_hsa052061.12563940
62PI3K-Akt signaling pathway_Homo sapiens_hsa041511.08791056
63FoxO signaling pathway_Homo sapiens_hsa040681.08496483
64Antigen processing and presentation_Homo sapiens_hsa046121.06747691
65Pancreatic cancer_Homo sapiens_hsa052121.04937765
66Asthma_Homo sapiens_hsa053101.04682794
67Endometrial cancer_Homo sapiens_hsa052131.02953340
68Colorectal cancer_Homo sapiens_hsa052101.02521810
69Wnt signaling pathway_Homo sapiens_hsa043101.02473487
70HTLV-I infection_Homo sapiens_hsa051661.00751484
71Thyroid cancer_Homo sapiens_hsa052160.99397205
72VEGF signaling pathway_Homo sapiens_hsa043700.97865472
73Mineral absorption_Homo sapiens_hsa049780.97642983
74Phagosome_Homo sapiens_hsa041450.97017407
75Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.96223665
76HIF-1 signaling pathway_Homo sapiens_hsa040660.95690937
77Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.95366587
78Shigellosis_Homo sapiens_hsa051310.95078621
79Melanogenesis_Homo sapiens_hsa049160.94168168
80Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.92540379
81Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.91617825
82Estrogen signaling pathway_Homo sapiens_hsa049150.89820791
83Viral carcinogenesis_Homo sapiens_hsa052030.89586629
84Glycosaminoglycan degradation_Homo sapiens_hsa005310.88160511
85Melanoma_Homo sapiens_hsa052180.88074834
86Endocytosis_Homo sapiens_hsa041440.86756560
87Hedgehog signaling pathway_Homo sapiens_hsa043400.84273814
88SNARE interactions in vesicular transport_Homo sapiens_hsa041300.82492250
89Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.81942116
90Pertussis_Homo sapiens_hsa051330.80801744
91Sphingolipid signaling pathway_Homo sapiens_hsa040710.80793237
92Leishmaniasis_Homo sapiens_hsa051400.79603857
93TNF signaling pathway_Homo sapiens_hsa046680.78036734
94Thyroid hormone signaling pathway_Homo sapiens_hsa049190.76730427
95Salmonella infection_Homo sapiens_hsa051320.76636521
96Axon guidance_Homo sapiens_hsa043600.76372427
97Insulin signaling pathway_Homo sapiens_hsa049100.75946534
98Dorso-ventral axis formation_Homo sapiens_hsa043200.75777066
99Gastric acid secretion_Homo sapiens_hsa049710.75262404
100Epstein-Barr virus infection_Homo sapiens_hsa051690.74325591
101Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.73960751
102Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.73367508
103Type I diabetes mellitus_Homo sapiens_hsa049400.73134113
104cGMP-PKG signaling pathway_Homo sapiens_hsa040220.71175281
105Pentose phosphate pathway_Homo sapiens_hsa000300.70936738
106Phosphatidylinositol signaling system_Homo sapiens_hsa040700.70827492
107Acute myeloid leukemia_Homo sapiens_hsa052210.70794048
108AMPK signaling pathway_Homo sapiens_hsa041520.69995734
109Rheumatoid arthritis_Homo sapiens_hsa053230.69937906
110Adipocytokine signaling pathway_Homo sapiens_hsa049200.68754815
111Longevity regulating pathway - mammal_Homo sapiens_hsa042110.68300380
112Prolactin signaling pathway_Homo sapiens_hsa049170.67006095
113Vascular smooth muscle contraction_Homo sapiens_hsa042700.66801372
114Lysosome_Homo sapiens_hsa041420.65756844
115Hepatitis C_Homo sapiens_hsa051600.64939721
116Malaria_Homo sapiens_hsa051440.64692734
117Hepatitis B_Homo sapiens_hsa051610.64384032
118p53 signaling pathway_Homo sapiens_hsa041150.63972827
119Vitamin digestion and absorption_Homo sapiens_hsa049770.61593804
120Osteoclast differentiation_Homo sapiens_hsa043800.60891319
121Intestinal immune network for IgA production_Homo sapiens_hsa046720.60660683
122Apoptosis_Homo sapiens_hsa042100.60457987
123Ras signaling pathway_Homo sapiens_hsa040140.60092758
124mTOR signaling pathway_Homo sapiens_hsa041500.59763746
125Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.59681499
126Glioma_Homo sapiens_hsa052140.59042532
127MAPK signaling pathway_Homo sapiens_hsa040100.58196884
128Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.55408374
129Choline metabolism in cancer_Homo sapiens_hsa052310.51494491
130Inositol phosphate metabolism_Homo sapiens_hsa005620.51240447
131Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.50391340
132Thyroid hormone synthesis_Homo sapiens_hsa049180.50356983
133Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.50288489
134Fat digestion and absorption_Homo sapiens_hsa049750.48006893
135GnRH signaling pathway_Homo sapiens_hsa049120.47558881
136Transcriptional misregulation in cancer_Homo sapiens_hsa052020.46646383
137Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.46408979
138Neurotrophin signaling pathway_Homo sapiens_hsa047220.45245725
139Phospholipase D signaling pathway_Homo sapiens_hsa040720.44603944
140Gap junction_Homo sapiens_hsa045400.43822716
141Renin-angiotensin system_Homo sapiens_hsa046140.42888016
142Pancreatic secretion_Homo sapiens_hsa049720.41546335
143Jak-STAT signaling pathway_Homo sapiens_hsa046300.41227001
144Circadian rhythm_Homo sapiens_hsa047100.40237412
145Galactose metabolism_Homo sapiens_hsa000520.40200154

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