FAM102B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)8.05673517
2nuclear pore organization (GO:0006999)6.65700545
3pore complex assembly (GO:0046931)5.92042010
4regulation of centriole replication (GO:0046599)4.95475994
5hepatocyte apoptotic process (GO:0097284)4.85642295
6antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.58738164
7mitotic sister chromatid cohesion (GO:0007064)4.58274855
8positive regulation by symbiont of host defense response (GO:0052509)4.51026079
9modulation by symbiont of host defense response (GO:0052031)4.51026079
10modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.51026079
11modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.51026079
12positive regulation by organism of defense response of other organism involved in symbiotic interact4.51026079
13modulation by symbiont of host immune response (GO:0052553)4.51026079
14midgut development (GO:0007494)4.32864740
15embryonic process involved in female pregnancy (GO:0060136)4.28514761
16DNA unwinding involved in DNA replication (GO:0006268)4.27302316
17macrophage activation involved in immune response (GO:0002281)4.12168451
18regulation of histone H3-K27 methylation (GO:0061085)4.07098701
19microglial cell activation (GO:0001774)3.96541013
20definitive hemopoiesis (GO:0060216)3.86998189
21regulation of interferon-beta biosynthetic process (GO:0045357)3.82728451
22regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.81337635
23urea cycle (GO:0000050)3.69448381
24regulation of establishment of cell polarity (GO:2000114)3.66174644
25regulation of RNA export from nucleus (GO:0046831)3.64438108
26positive regulation of keratinocyte differentiation (GO:0045618)3.64322796
27regulation of nucleobase-containing compound transport (GO:0032239)3.48097759
28phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.40665859
29neutrophil activation involved in immune response (GO:0002283)3.39711596
30negative regulation of erythrocyte differentiation (GO:0045647)3.36891688
31mitotic chromosome condensation (GO:0007076)3.35044574
32positive regulation of interferon-alpha production (GO:0032727)3.30485396
33negative regulation of DNA repair (GO:0045738)3.26562229
34sister chromatid segregation (GO:0000819)3.25860329
35Rap protein signal transduction (GO:0032486)3.23868708
36response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.19064438
37response to host immune response (GO:0052572)3.19064438
38TOR signaling (GO:0031929)3.17842629
39urea metabolic process (GO:0019627)3.16742605
40DNA duplex unwinding (GO:0032508)3.15138238
41regulation of centrosome duplication (GO:0010824)3.15055226
42homocysteine metabolic process (GO:0050667)3.14607201
43regulation of establishment or maintenance of cell polarity (GO:0032878)3.10087159
44macrophage activation (GO:0042116)3.08853678
45regulation of interferon-alpha production (GO:0032647)3.08642576
46positive regulation of cellular amide metabolic process (GO:0034250)3.04731284
47embryonic camera-type eye morphogenesis (GO:0048596)3.03249812
48positive regulation of chemokine biosynthetic process (GO:0045080)3.01370030
49DNA geometric change (GO:0032392)2.99453827
50positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.96126299
51mitotic nuclear envelope disassembly (GO:0007077)2.95992232
52dosage compensation (GO:0007549)2.95910121
53lipopolysaccharide-mediated signaling pathway (GO:0031663)2.94788967
54iron ion import (GO:0097286)2.93686152
55response to peptidoglycan (GO:0032494)2.93533351
56hepatocyte differentiation (GO:0070365)2.92807072
57nuclear envelope disassembly (GO:0051081)2.91115928
58membrane disassembly (GO:0030397)2.91115928
59response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.89106553
60response to host (GO:0075136)2.89106553
61response to host defenses (GO:0052200)2.89106553
62corticosteroid receptor signaling pathway (GO:0031958)2.88692246
63negative regulation of neurotransmitter secretion (GO:0046929)2.88617271
64citrulline metabolic process (GO:0000052)2.87996427
65trophectodermal cell differentiation (GO:0001829)2.87668152
66positive regulation of Cdc42 GTPase activity (GO:0043089)2.87168148
67cellular protein complex localization (GO:0034629)2.85496072
68cellular response to ethanol (GO:0071361)2.85196720
69positive regulation of macrophage cytokine production (GO:0060907)2.84241353
70production of molecular mediator involved in inflammatory response (GO:0002532)2.83642275
71regulation of centrosome cycle (GO:0046605)2.83502418
72mitotic sister chromatid segregation (GO:0000070)2.81863237
73protein export from nucleus (GO:0006611)2.79838123
74nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.79444637
75positive regulation of gamma-delta T cell activation (GO:0046645)2.78419498
76positive regulation of heat generation (GO:0031652)2.77447132
77positive regulation of protein import into nucleus, translocation (GO:0033160)2.77423804
78monoubiquitinated protein deubiquitination (GO:0035520)2.76937252
79regulation of fever generation (GO:0031620)2.76865613
80regulation of Rac protein signal transduction (GO:0035020)2.76509159
81response to laminar fluid shear stress (GO:0034616)2.73810134
82regulation of mitotic spindle organization (GO:0060236)2.73119664
83cell adhesion mediated by integrin (GO:0033627)2.70861333
84respiratory burst (GO:0045730)2.68837950
85nitrogen cycle metabolic process (GO:0071941)2.67508459
86I-kappaB phosphorylation (GO:0007252)2.67276138
87myeloid cell activation involved in immune response (GO:0002275)2.65791869
88granulocyte activation (GO:0036230)2.65334098
89hydrogen peroxide biosynthetic process (GO:0050665)2.64925932
90regulation of DNA damage checkpoint (GO:2000001)2.64388582
91cellular response to exogenous dsRNA (GO:0071360)2.63666106
92regulation of macrophage cytokine production (GO:0010935)2.60307428
93positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.59821512
94sister chromatid cohesion (GO:0007062)2.59209543
95citrulline biosynthetic process (GO:0019240)2.58815751
96pre-miRNA processing (GO:0031054)2.58285559
97peptidyl-threonine modification (GO:0018210)2.57743472
98embryonic eye morphogenesis (GO:0048048)2.56836088
99cytoskeletal anchoring at plasma membrane (GO:0007016)2.55711934
100positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.55645244
101activation of Rac GTPase activity (GO:0032863)2.55126487
102negative regulation of homotypic cell-cell adhesion (GO:0034111)2.54969400
103proline transport (GO:0015824)2.54684116
104necroptotic process (GO:0070266)2.52339372
105glucocorticoid receptor signaling pathway (GO:0042921)2.51752717
106striated muscle atrophy (GO:0014891)2.49729264
107interferon-gamma-mediated signaling pathway (GO:0060333)2.49673122
108cellular response to interferon-alpha (GO:0035457)2.49409156
109cAMP catabolic process (GO:0006198)2.49327374
110regulation of monocyte chemotaxis (GO:0090025)2.48834353
111neutrophil activation (GO:0042119)2.48444592
112DNA topological change (GO:0006265)2.46895061
113protein complex localization (GO:0031503)2.46442048
114peptidyl-threonine phosphorylation (GO:0018107)2.46358596
115immunoglobulin mediated immune response (GO:0016064)2.45637711
116detection of molecule of bacterial origin (GO:0032490)2.45220699
117positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.44692128
118mammary gland epithelial cell proliferation (GO:0033598)2.40919746
119regulation of chemokine biosynthetic process (GO:0045073)2.39090296
120positive regulation of monocyte chemotaxis (GO:0090026)2.38488673
121negative regulation of cell killing (GO:0031342)2.37620593
122negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.37620593
123superoxide anion generation (GO:0042554)2.37148432
124COPI coating of Golgi vesicle (GO:0048205)2.36752827
125Golgi transport vesicle coating (GO:0048200)2.36752827
126cytoplasmic mRNA processing body assembly (GO:0033962)2.36212573
127regulation of early endosome to late endosome transport (GO:2000641)2.35883580
128monocyte chemotaxis (GO:0002548)2.35390162
129clathrin coat assembly (GO:0048268)2.35336004
130DNA conformation change (GO:0071103)2.34294525
131reactive oxygen species biosynthetic process (GO:1903409)2.33956465
132positive regulation of mast cell degranulation (GO:0043306)2.33786101
133positive regulation of mast cell activation involved in immune response (GO:0033008)2.33786101
134negative regulation of interleukin-17 production (GO:0032700)2.33288729
135regulation of keratinocyte differentiation (GO:0045616)2.32417144
136positive regulation of bone resorption (GO:0045780)2.31291501
137positive regulation of bone remodeling (GO:0046852)2.31291501
138mRNA stabilization (GO:0048255)2.30841270
139RNA stabilization (GO:0043489)2.30841270
140peptidyl-threonine dephosphorylation (GO:0035970)2.30611348
141centrosome duplication (GO:0051298)2.30216343
142positive regulation of chemokine production (GO:0032722)2.30050863
143response to epidermal growth factor (GO:0070849)2.29444811
144DNA replication initiation (GO:0006270)2.28879859
145positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.28612586
146cytokine production involved in immune response (GO:0002367)2.28022374
147positive regulation of translational initiation (GO:0045948)2.27786466
148regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.27610127
149regulation of mononuclear cell migration (GO:0071675)2.26985584
150substrate-dependent cell migration (GO:0006929)2.26942526
151keratan sulfate catabolic process (GO:0042340)2.26893818
152muscle atrophy (GO:0014889)2.26136178
153nuclear envelope organization (GO:0006998)2.25433060
154negative regulation of protein localization to plasma membrane (GO:1903077)2.25415594
155nerve growth factor signaling pathway (GO:0038180)2.24862545
156regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.24842347
157regulation of synapse structural plasticity (GO:0051823)2.24334689
158positive regulation of chromosome segregation (GO:0051984)2.24190253
159histone H3-K36 demethylation (GO:0070544)2.23883405
160phagosome maturation (GO:0090382)2.23653022
161necrotic cell death (GO:0070265)2.23652214
162response to food (GO:0032094)2.23249297
163regulation of homotypic cell-cell adhesion (GO:0034110)2.23112673
164regulation of platelet aggregation (GO:0090330)2.22663765
165regulation of ARF protein signal transduction (GO:0032012)2.22365834
166regulation of NFAT protein import into nucleus (GO:0051532)2.20950145
167negative regulation of systemic arterial blood pressure (GO:0003085)2.16766809
168neutrophil chemotaxis (GO:0030593)2.16542608
169response to muramyl dipeptide (GO:0032495)2.15841680
170response to manganese ion (GO:0010042)2.15654116
171G-protein coupled purinergic receptor signaling pathway (GO:0035588)2.15406517
172membrane assembly (GO:0071709)2.12147701
173myeloid leukocyte activation (GO:0002274)2.10890352
174positive regulation of mast cell activation (GO:0033005)2.09678999
175neutrophil migration (GO:1990266)2.09650681
176regulation of heat generation (GO:0031650)2.09334755
177regulation of myeloid cell apoptotic process (GO:0033032)2.08743614
178G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.07571670
179phagocytosis, engulfment (GO:0006911)2.07230447
180response to nerve growth factor (GO:1990089)2.06924343
181cellular response to nerve growth factor stimulus (GO:1990090)2.06924343
182barbed-end actin filament capping (GO:0051016)2.06759473
183positive regulation of interferon-beta production (GO:0032728)2.05658943
184neuron projection extension involved in neuron projection guidance (GO:1902284)2.04766988
185axon extension involved in axon guidance (GO:0048846)2.04766988
186type I interferon signaling pathway (GO:0060337)2.04448591
187cellular response to type I interferon (GO:0071357)2.04448591
188response to type I interferon (GO:0034340)2.04014665
189histamine secretion (GO:0001821)2.03785303
190natural killer cell mediated cytotoxicity (GO:0042267)2.03583715
191natural killer cell mediated immunity (GO:0002228)2.03583715
192stress fiber assembly (GO:0043149)2.03503739
193negative regulation of amino acid transport (GO:0051956)2.03468807
194synaptic vesicle maturation (GO:0016188)2.03349630
195positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.02058531
196regulation of mast cell degranulation (GO:0043304)2.01487552
197lymphocyte chemotaxis (GO:0048247)2.01273991

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.44460642
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.41484129
3IRF8_21731497_ChIP-ChIP_J774_Mouse3.69950620
4GATA1_22025678_ChIP-Seq_K562_Human3.38491318
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.14826019
6BP1_19119308_ChIP-ChIP_Hs578T_Human2.95922192
7ZNF263_19887448_ChIP-Seq_K562_Human2.78756787
8SALL1_21062744_ChIP-ChIP_HESCs_Human2.70902568
9SMAD_19615063_ChIP-ChIP_OVARY_Human2.69539129
10IRF8_27001747_Chip-Seq_BMDM_Mouse2.65165650
11E2F4_17652178_ChIP-ChIP_JURKAT_Human2.62949685
12TRIM28_21343339_ChIP-Seq_HEK293_Human2.58872541
13Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.56716338
14KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.52398992
15FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.48732518
16ESR1_21235772_ChIP-Seq_MCF-7_Human2.43710546
17SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.38342185
18PKCTHETA_26484144_Chip-Seq_BREAST_Human2.31224289
19PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.11012327
20CDX2_19796622_ChIP-Seq_MESCs_Mouse2.10030825
21NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.09781070
22NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.05285008
23IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.02479205
24ESR1_15608294_ChIP-ChIP_MCF-7_Human2.00745579
25AR_21909140_ChIP-Seq_LNCAP_Human1.94322627
26MYC_22102868_ChIP-Seq_BL_Human1.92115429
27* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.91604425
28EGR1_19374776_ChIP-ChIP_THP-1_Human1.90836132
29WT1_19549856_ChIP-ChIP_CCG9911_Human1.83903380
30E2F1_21310950_ChIP-Seq_MCF-7_Human1.83229906
31SCL_19346495_ChIP-Seq_HPC-7_Human1.81345519
32SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.80815911
33SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.73066305
34* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.72916733
35STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.69778230
36NRF2_20460467_ChIP-Seq_MEFs_Mouse1.68857880
37NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.68857880
38SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.68561464
39SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.67985400
40TCF7_22412390_ChIP-Seq_EML_Mouse1.66495975
41GBX2_23144817_ChIP-Seq_PC3_Human1.65411396
42* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.65388419
43TFEB_21752829_ChIP-Seq_HELA_Human1.65251336
44VDR_24787735_ChIP-Seq_THP-1_Human1.65077664
45RBPJ_22232070_ChIP-Seq_NCS_Mouse1.64871234
46IKZF1_21737484_ChIP-ChIP_HCT116_Human1.64809856
47CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.63387740
48CJUN_26792858_Chip-Seq_BT549_Human1.61482258
49* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.60783765
50SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.58362333
51RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.57192335
52* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.54081271
53RUNX1_27514584_Chip-Seq_MCF-7_Human1.53015460
54STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.50512958
55CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.50478503
56FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.48422086
57SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.47909770
58* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.47506542
59AR_21572438_ChIP-Seq_LNCaP_Human1.47476277
60CLOCK_20551151_ChIP-Seq_293T_Human1.46813104
61EZH2_18974828_ChIP-Seq_MESCs_Mouse1.44750405
62RNF2_18974828_ChIP-Seq_MESCs_Mouse1.44750405
63MTF2_20144788_ChIP-Seq_MESCs_Mouse1.43619199
64TP53_18474530_ChIP-ChIP_U2OS_Human1.41611268
65CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.40938423
66MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.39793417
67VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.39504406
68GATA2_21666600_ChIP-Seq_HMVEC_Human1.39335087
69JARID2_20064375_ChIP-Seq_MESCs_Mouse1.37241016
70GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36821054
71TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.35784807
72* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.34675977
73PADI4_21655091_ChIP-ChIP_MCF-7_Human1.34341158
74NR3C1_23031785_ChIP-Seq_PC12_Mouse1.34281563
75* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.33495095
76* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.33154435
77SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.32606112
78* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.32599007
79PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.30914059
80DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.29390057
81ZFX_18555785_ChIP-Seq_MESCs_Mouse1.27791053
82HIF1A_21447827_ChIP-Seq_MCF-7_Human1.27041590
83BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.26455756
84* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.23629144
85IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.23617798
86SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.21917780
87SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.21917780
88SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.21886257
89FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.21834532
90SPI1_23127762_ChIP-Seq_K562_Human1.21528793
91EED_16625203_ChIP-ChIP_MESCs_Mouse1.21229431
92ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.19940581
93JARID2_20075857_ChIP-Seq_MESCs_Mouse1.19808720
94MYCN_18555785_ChIP-Seq_MESCs_Mouse1.19344193
95* SOX2_20726797_ChIP-Seq_SW620_Human1.18674182
96* SPI1_23547873_ChIP-Seq_NB4_Human1.18056493
97NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.15357936
98RUNX_20019798_ChIP-Seq_JUKART_Human1.15345297
99ER_23166858_ChIP-Seq_MCF-7_Human1.15280812
100* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.14189244
101* SMAD4_21799915_ChIP-Seq_A2780_Human1.14108269
102RARG_19884340_ChIP-ChIP_MEFs_Mouse1.13058449
103EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.12830391
104KLF4_18555785_ChIP-Seq_MESCs_Mouse1.12619619
105VDR_21846776_ChIP-Seq_THP-1_Human1.10836625
106ESR1_20079471_ChIP-ChIP_T-47D_Human1.10783418
107* ARNT_22903824_ChIP-Seq_MCF-7_Human1.10338191
108KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.10053880
109THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.09454016
110PIAS1_25552417_ChIP-Seq_VCAP_Human1.09330920
111CHD1_26751641_Chip-Seq_LNCaP_Human1.08992485
112SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08731967
113RXR_22108803_ChIP-Seq_LS180_Human1.08178428
114RNF2_27304074_Chip-Seq_ESCs_Mouse1.08169813
115NCOR1_26117541_ChIP-Seq_K562_Human1.08167036
116TP53_16413492_ChIP-PET_HCT116_Human1.08038466
117SALL4_18804426_ChIP-ChIP_XEN_Mouse1.07820166
118AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.07122670
119* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.06873492
120TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.05598086
121FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.04563931
122* GATA3_24758297_ChIP-Seq_MCF-7_Human1.04123436
123EP300_21415370_ChIP-Seq_HL-1_Mouse1.04111007
124CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.03091416
125PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02839345
126OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02630219
127SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02538038
128PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02385885
129* MYB_26560356_Chip-Seq_TH2_Human1.02219346
130RUNX1_22412390_ChIP-Seq_EML_Mouse1.01866987
131NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.01634790
132MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.01587508
133TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.00729824
134SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.00405588
135CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.00214154
136P300_19829295_ChIP-Seq_ESCs_Human0.99944325
137DROSHA_22980978_ChIP-Seq_HELA_Human0.99876950
138WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.99523507
139BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.98772047
140* MYB_26560356_Chip-Seq_TH1_Human0.98582405
141KDM2B_26808549_Chip-Seq_DND41_Human0.96978689
142GATA6_25053715_ChIP-Seq_YYC3_Human0.96684978
143JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.96380812
144* SOX2_27498859_Chip-Seq_STOMACH_Mouse0.96121450
145TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.95712797
146TOP2B_26459242_ChIP-Seq_MCF-7_Human0.95216078
147YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.94998430
148MYC_18555785_ChIP-Seq_MESCs_Mouse0.94922841
149EZH2_27304074_Chip-Seq_ESCs_Mouse0.94874208
150JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.93478680
151PPAR_26484153_Chip-Seq_NCI-H1993_Human0.93254438
152MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.92987964
153VDR_24763502_ChIP-Seq_THP-1_Human0.92569719
154ESR2_21235772_ChIP-Seq_MCF-7_Human0.92455305
155NELFA_20434984_ChIP-Seq_ESCs_Mouse0.92412514
156EZH2_22144423_ChIP-Seq_EOC_Human0.92285932
157BRD4_25478319_ChIP-Seq_HGPS_Human0.92135759
158PU_27001747_Chip-Seq_BMDM_Mouse0.91885116
159* SUZ12_27294783_Chip-Seq_ESCs_Mouse0.90691870
160KDM2B_26808549_Chip-Seq_SUP-B15_Human0.90000897
161* TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.89620661
162ETS1_22383799_ChIP-Seq_G1ME_Mouse0.88571805
163HOXB4_20404135_ChIP-ChIP_EML_Mouse0.88540104
164PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.88420520
165* AHR_22903824_ChIP-Seq_MCF-7_Human0.88161231
166RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.88105753
167POU3F2_20337985_ChIP-ChIP_501MEL_Human0.87796805
168MYC_19079543_ChIP-ChIP_MESCs_Mouse0.87696200
169AR_25329375_ChIP-Seq_VCAP_Human0.87160851
170ZFP57_27257070_Chip-Seq_ESCs_Mouse0.86758790
171* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.86142095
172* GATA2_19941826_ChIP-Seq_K562_Human0.85497346
173STAT4_19710469_ChIP-ChIP_TH1__Mouse0.84923097
174* RACK7_27058665_Chip-Seq_MCF-7_Human0.84372226
175ELF5_23300383_ChIP-Seq_T47D_Human0.84225477

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.90803581
2MP0002009_preneoplasia4.47143270
3MP0002877_abnormal_melanocyte_morpholog3.88106307
4MP0010352_gastrointestinal_tract_polyps3.40195792
5MP0008438_abnormal_cutaneous_collagen3.36011623
6MP0003303_peritoneal_inflammation3.10687379
7MP0002396_abnormal_hematopoietic_system2.82573440
8MP0004858_abnormal_nervous_system2.74315105
9MP0004808_abnormal_hematopoietic_stem2.67579383
10MP0001835_abnormal_antigen_presentation2.64762284
11MP0006082_CNS_inflammation2.63896159
12MP0003724_increased_susceptibility_to2.58654410
13MP0000569_abnormal_digit_pigmentation2.47525216
14MP0010307_abnormal_tumor_latency2.42655881
15MP0002148_abnormal_hypersensitivity_rea2.25066398
16MP0010094_abnormal_chromosome_stability2.19093453
17MP0002419_abnormal_innate_immunity2.18717789
18MP0009785_altered_susceptibility_to2.15235857
19MP0005058_abnormal_lysosome_morphology2.12596831
20MP0001533_abnormal_skeleton_physiology2.10721910
21MP0004510_myositis2.09202041
22MP0003436_decreased_susceptibility_to2.09158053
23MP0003075_altered_response_to2.07772476
24MP0003045_fibrosis2.00549229
25MP0004957_abnormal_blastocyst_morpholog1.95558555
26MP0004233_abnormal_muscle_weight1.94388193
27MP0004859_abnormal_synaptic_plasticity1.92391652
28MP0003191_abnormal_cellular_cholesterol1.90976488
29MP0005451_abnormal_body_composition1.89835438
30MP0003111_abnormal_nucleus_morphology1.82440975
31MP0003705_abnormal_hypodermis_morpholog1.81056797
32MP0005167_abnormal_blood-brain_barrier1.79889081
33MP0005275_abnormal_skin_tensile1.78535549
34MP0005000_abnormal_immune_tolerance1.76484167
35MP0005083_abnormal_biliary_tract1.75999945
36MP0003077_abnormal_cell_cycle1.75009620
37MP0000343_altered_response_to1.74372389
38MP0005464_abnormal_platelet_physiology1.73665537
39MP0002735_abnormal_chemical_nociception1.73591863
40MP0003172_abnormal_lysosome_physiology1.72798764
41MP0004264_abnormal_extraembryonic_tissu1.72387305
42MP0010678_abnormal_skin_adnexa1.72311490
43MP0004185_abnormal_adipocyte_glucose1.68378141
44MP0005409_darkened_coat_color1.68192749
45MP0002998_abnormal_bone_remodeling1.66682129
46MP0009780_abnormal_chondrocyte_physiolo1.65698824
47MP0003091_abnormal_cell_migration1.64385340
48MP0001968_abnormal_touch/_nociception1.63525824
49MP0005503_abnormal_tendon_morphology1.61511381
50MP0003279_aneurysm1.57155648
51MP0003448_altered_tumor_morphology1.56694694
52MP0005025_abnormal_response_to1.56266402
53MP0005164_abnormal_response_to1.56150548
54MP0001958_emphysema1.55670180
55MP0004272_abnormal_basement_membrane1.49108439
56MP0002736_abnormal_nociception_after1.47627320
57MP0005166_decreased_susceptibility_to1.46557207
58MP0003656_abnormal_erythrocyte_physiolo1.45996586
59MP0000383_abnormal_hair_follicle1.43406711
60MP0003828_pulmonary_edema1.43328800
61MP0002452_abnormal_antigen_presenting1.41585066
62MP0009278_abnormal_bone_marrow1.41063460
63MP0004130_abnormal_muscle_cell1.40588198
64MP0008260_abnormal_autophagy1.40403991
65MP0000350_abnormal_cell_proliferation1.37134967
66MP0002006_tumorigenesis1.37112130
67MP0002822_catalepsy1.36624821
68MP0001790_abnormal_immune_system1.33572713
69MP0005387_immune_system_phenotype1.33572713
70MP0003690_abnormal_glial_cell1.31784266
71MP0005671_abnormal_response_to1.28973911
72MP0003763_abnormal_thymus_physiology1.27306229
73MP0001501_abnormal_sleep_pattern1.26976737
74MP0003221_abnormal_cardiomyocyte_apopto1.26630764
75MP0002086_abnormal_extraembryonic_tissu1.26336507
76MP0005390_skeleton_phenotype1.24031914
77MP0004883_abnormal_blood_vessel1.21259472
78MP0005621_abnormal_cell_physiology1.21240517
79MP0003693_abnormal_embryo_hatching1.21090065
80MP0003566_abnormal_cell_adhesion1.20926717
81MP0002733_abnormal_thermal_nociception1.20361053
82MP0004381_abnormal_hair_follicle1.20170601
83MP0002796_impaired_skin_barrier1.19668734
84MP0002723_abnormal_immune_serum1.16397302
85MP0002088_abnormal_embryonic_growth/wei1.15819076
86MP0000604_amyloidosis1.15417375
87MP0000427_abnormal_hair_cycle1.14420286
88MP0001348_abnormal_lacrimal_gland1.14132306
89MP0001819_abnormal_immune_cell1.13633432
90MP0001697_abnormal_embryo_size1.13164324
91MP0001672_abnormal_embryogenesis/_devel1.11921490
92MP0005380_embryogenesis_phenotype1.11921490
93MP0003984_embryonic_growth_retardation1.11731976
94MP0000685_abnormal_immune_system1.09179175
95MP0008007_abnormal_cellular_replicative1.08335950
96MP0002420_abnormal_adaptive_immunity1.08052797
97MP0003300_gastrointestinal_ulcer1.07725917
98MP0005408_hypopigmentation1.06954656
99MP0000490_abnormal_crypts_of1.06826057
100MP0009672_abnormal_birth_weight1.06381449
101MP0001879_abnormal_lymphatic_vessel1.06313766
102MP0000627_abnormal_mammary_gland1.05958206
103MP0000015_abnormal_ear_pigmentation1.05718811
104MP0001730_embryonic_growth_arrest1.05705607
105MP0009764_decreased_sensitivity_to1.05061642
106MP0003183_abnormal_peptide_metabolism1.03634976
107MP0001849_ear_inflammation1.03366247
108MP0001970_abnormal_pain_threshold1.01927676
109MP0010234_abnormal_vibrissa_follicle1.01771477
110MP0005076_abnormal_cell_differentiation1.01173613
111MP0002332_abnormal_exercise_endurance0.99023243
112MP0000767_abnormal_smooth_muscle0.98893217
113MP0002080_prenatal_lethality0.98889993
114MP0002734_abnormal_mechanical_nocicepti0.98606363
115MP0001299_abnormal_eye_distance/0.98575097
116MP0001545_abnormal_hematopoietic_system0.97576953
117MP0005397_hematopoietic_system_phenotyp0.97576953
118MP0004270_analgesia0.97364573
119MP0010386_abnormal_urinary_bladder0.96623658
120MP0003635_abnormal_synaptic_transmissio0.96433654
121MP0001845_abnormal_inflammatory_respons0.95270019
122MP0001853_heart_inflammation0.94973150
123MP0001800_abnormal_humoral_immune0.94864044
124MP0000371_diluted_coat_color0.93118678
125MP0008004_abnormal_stomach_pH0.92953860
126MP0000377_abnormal_hair_follicle0.92831645
127MP0005384_cellular_phenotype0.92806461
128MP0000703_abnormal_thymus_morphology0.92346896
129MP0006054_spinal_hemorrhage0.91989286
130MP0000313_abnormal_cell_death0.91940015
131MP0009703_decreased_birth_body0.90846172
132MP0003453_abnormal_keratinocyte_physiol0.90754809
133MP0001873_stomach_inflammation0.90464573
134MP0008058_abnormal_DNA_repair0.89989571
135MP0002063_abnormal_learning/memory/cond0.89792024
136MP0004947_skin_inflammation0.89638408
137MP0009115_abnormal_fat_cell0.89592595
138MP0003950_abnormal_plasma_membrane0.89421470
139MP0002166_altered_tumor_susceptibility0.88506166
140MP0000858_altered_metastatic_potential0.87157361
141MP0000249_abnormal_blood_vessel0.85666427
142MP0005310_abnormal_salivary_gland0.85428911
143MP0005171_absent_coat_pigmentation0.85323725
144MP0010155_abnormal_intestine_physiology0.84553366
145MP0003633_abnormal_nervous_system0.83720477
146MP0005647_abnormal_sex_gland0.81993803
147MP0002019_abnormal_tumor_incidence0.81911981
148MP0001542_abnormal_bone_strength0.81410359
149MP0001881_abnormal_mammary_gland0.81076228
150MP0002090_abnormal_vision0.80050541
151MP0009745_abnormal_behavioral_response0.78930758
152MP0002398_abnormal_bone_marrow0.78103902
153MP0009046_muscle_twitch0.77958052
154MP0002064_seizures0.77430724
155MP0004782_abnormal_surfactant_physiolog0.77202895
156MP0004147_increased_porphyrin_level0.76325519
157MP0005623_abnormal_meninges_morphology0.75630095
158MP0003795_abnormal_bone_structure0.74139726
159MP0000462_abnormal_digestive_system0.73746875
160MP0000013_abnormal_adipose_tissue0.73614372
161MP0002405_respiratory_system_inflammati0.73200986
162MP0001177_atelectasis0.72997853
163MP0001851_eye_inflammation0.72978974
164MP0005075_abnormal_melanosome_morpholog0.72813100
165MP0003866_abnormal_defecation0.72005443
166MP0002722_abnormal_immune_system0.71551874
167MP0005666_abnormal_adipose_tissue0.70862390
168MP0005501_abnormal_skin_physiology0.68498077
169MP0002896_abnormal_bone_mineralization0.66601524
170MP0009697_abnormal_copulation0.66349596
171MP0005174_abnormal_tail_pigmentation0.65431476
172MP0001191_abnormal_skin_condition0.64665900
173MP0002098_abnormal_vibrissa_morphology0.64586292

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)4.80318463
2Recurrent abscess formation (HP:0002722)4.51999545
3Recurrent bacterial skin infections (HP:0005406)4.17460928
4Deep philtrum (HP:0002002)3.91934867
5Systemic lupus erythematosus (HP:0002725)3.84409351
6Chromosomal breakage induced by crosslinking agents (HP:0003221)3.47247882
7J-shaped sella turcica (HP:0002680)3.47239898
8Micronodular cirrhosis (HP:0001413)3.43197440
9Recurrent gram-negative bacterial infections (HP:0005420)3.40618893
10Insidious onset (HP:0003587)3.37003389
11Termporal pattern (HP:0011008)3.37003389
12Papillary thyroid carcinoma (HP:0002895)3.27561969
13Chromsome breakage (HP:0040012)3.27389580
14Increased cerebral lipofuscin (HP:0011813)3.27246135
15Dysmetric saccades (HP:0000641)3.15125042
16Arterial tortuosity (HP:0005116)3.10439761
17Aplasia/Hypoplasia involving the sinuses (HP:0009120)3.09083772
18Disinhibition (HP:0000734)3.06918687
19Vascular tortuosity (HP:0004948)3.05835840
20Mutism (HP:0002300)3.04096472
21Acute myeloid leukemia (HP:0004808)3.03948622
22Curly hair (HP:0002212)3.03089031
23Increased neuronal autofluorescent lipopigment (HP:0002074)2.95570396
24Cerebral aneurysm (HP:0004944)2.94713315
25Autoimmune thrombocytopenia (HP:0001973)2.88042761
26Mediastinal lymphadenopathy (HP:0100721)2.85850427
27Hematochezia (HP:0002573)2.82642194
28Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.78268625
29Abnormality of the ischium (HP:0003174)2.72668039
30Abnormality of glycosphingolipid metabolism (HP:0004343)2.71741368
31Abnormality of glycolipid metabolism (HP:0010969)2.71741368
32Abnormality of liposaccharide metabolism (HP:0010968)2.71741368
33Gingivitis (HP:0000230)2.68737897
34Sparse lateral eyebrow (HP:0005338)2.67297189
35Glomerulonephritis (HP:0000099)2.65933369
36Absent frontal sinuses (HP:0002688)2.65849481
37Abnormality of macrophages (HP:0004311)2.64736378
38Relative macrocephaly (HP:0004482)2.62403307
39Ankyloglossia (HP:0010296)2.62283400
40Axonal loss (HP:0003447)2.58078827
41Menstrual irregularities (HP:0000858)2.57257725
42Thyroid carcinoma (HP:0002890)2.53712473
43Macroorchidism (HP:0000053)2.49798205
44Submucous cleft hard palate (HP:0000176)2.42142417
45Nephroblastoma (Wilms tumor) (HP:0002667)2.39251203
46Aortic aneurysm (HP:0004942)2.38283782
47Interstitial pulmonary disease (HP:0006530)2.36156668
48Osteolytic defects of the phalanges of the hand (HP:0009771)2.35773657
49Osteolytic defects of the hand bones (HP:0009699)2.35773657
50Vertebral compression fractures (HP:0002953)2.35642695
51Abnormality of oral frenula (HP:0000190)2.35515683
52Deformed sella turcica (HP:0002681)2.34523980
53Acute lymphatic leukemia (HP:0006721)2.33435264
54Myositis (HP:0100614)2.32499794
55Recurrent skin infections (HP:0001581)2.32485728
56Heterotopia (HP:0002282)2.31642228
57Aortic dissection (HP:0002647)2.30397500
58Action tremor (HP:0002345)2.29294861
59Subacute progressive viral hepatitis (HP:0006572)2.25097783
60Papilledema (HP:0001085)2.24199322
61Sandal gap (HP:0001852)2.23022880
62Thick nail (HP:0001805)2.22861681
63Volvulus (HP:0002580)2.22630947
64Elevated erythrocyte sedimentation rate (HP:0003565)2.22221995
65Syringomyelia (HP:0003396)2.21758649
66Spinal cord lesions (HP:0100561)2.21758649
67Embryonal renal neoplasm (HP:0011794)2.21658706
68Inappropriate behavior (HP:0000719)2.18662714
69Dilatation of the ascending aorta (HP:0005111)2.17626629
70Large earlobe (HP:0009748)2.16127997
71Esophageal varix (HP:0002040)2.16105360
72Epiphyseal dysplasia (HP:0002656)2.11189961
73Asymmetry of the thorax (HP:0001555)2.11102507
74Viral hepatitis (HP:0006562)2.10048519
75Prostate neoplasm (HP:0100787)2.07861432
76Abnormality of chromosome stability (HP:0003220)2.07135327
77Camptodactyly of toe (HP:0001836)2.05525017
78Uterine leiomyosarcoma (HP:0002891)2.05238480
79Leiomyosarcoma (HP:0100243)2.05238480
80Orchitis (HP:0100796)2.04759537
81Fatigue (HP:0012378)2.03576234
82Cellulitis (HP:0100658)2.01226150
83Hyperacusis (HP:0010780)2.00905323
84Cervical subluxation (HP:0003308)2.00806870
85Breast carcinoma (HP:0003002)2.00310037
86Striae distensae (HP:0001065)1.99741195
87Agnosia (HP:0010524)1.99426990
88Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.97854046
89Recurrent fungal infections (HP:0002841)1.97794621
90Tetraparesis (HP:0002273)1.97579732
91Increased nuchal translucency (HP:0010880)1.97475067
92Apathy (HP:0000741)1.96994647
93Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.95988099
94Premature rupture of membranes (HP:0001788)1.95416878
95Dysostosis multiplex (HP:0000943)1.94682145
96Mitral valve prolapse (HP:0001634)1.94558450
97Urinary bladder sphincter dysfunction (HP:0002839)1.91991155
98Transitional cell carcinoma of the bladder (HP:0006740)1.91789368
99Abnormality of the lumbar spine (HP:0100712)1.90391916
100Cutaneous melanoma (HP:0012056)1.89784565
101Slow saccadic eye movements (HP:0000514)1.89606423
102Nephritis (HP:0000123)1.89541731
103Cafe-au-lait spot (HP:0000957)1.88633521
104Cystic hygroma (HP:0000476)1.88378675
105Diminished motivation (HP:0000745)1.87705529
106Abnormality of the periventricular white matter (HP:0002518)1.87645442
107Bladder carcinoma (HP:0002862)1.86709186
108Bladder neoplasm (HP:0009725)1.86709186
109Cubitus valgus (HP:0002967)1.86600609
110Thin bony cortex (HP:0002753)1.85638504
111Recurrent viral infections (HP:0004429)1.85203136
112Obstructive lung disease (HP:0006536)1.84162565
113Chronic obstructive pulmonary disease (HP:0006510)1.84162565
114Neuronal loss in central nervous system (HP:0002529)1.83505466
115Myokymia (HP:0002411)1.82865830
116Gastrointestinal carcinoma (HP:0002672)1.82486859
117Malignant gastrointestinal tract tumors (HP:0006749)1.82486859
118Abnormality of the corticospinal tract (HP:0002492)1.82386135
119Peritonitis (HP:0002586)1.82155398
120Optic neuritis (HP:0100653)1.82082814
121Retrobulbar optic neuritis (HP:0100654)1.82082814
122Basal ganglia calcification (HP:0002135)1.82031219
123Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.82024503
124Neoplasm of the thyroid gland (HP:0100031)1.79329180
125Protrusio acetabuli (HP:0003179)1.78154724
126Myelodysplasia (HP:0002863)1.77127043
127Coarse hair (HP:0002208)1.76875269
128Hypopigmentation of the fundus (HP:0007894)1.75978729
129Flat acetabular roof (HP:0003180)1.75520724
130Resting tremor (HP:0002322)1.75515856
131Osteomyelitis (HP:0002754)1.75239420
132Abnormality of the sella turcica (HP:0002679)1.74538511
133Flexion contracture of toe (HP:0005830)1.74197769
134Joint contractures involving the joints of the feet (HP:0100492)1.74197769
135Abnormality of the frontal sinuses (HP:0002687)1.73462953
136Prominent nose (HP:0000448)1.72834120
137Supranuclear gaze palsy (HP:0000605)1.71646248
138Orthostatic hypotension (HP:0001278)1.71450838
139Periodontitis (HP:0000704)1.70983437
140Short chin (HP:0000331)1.70965408
141Spondylolisthesis (HP:0003302)1.70433565
142Recurrent cutaneous fungal infections (HP:0011370)1.69961833
143Chronic mucocutaneous candidiasis (HP:0002728)1.69961833
144Deviation of the thumb (HP:0009603)1.69762862
145Myocardial infarction (HP:0001658)1.69645418
146Lower limb asymmetry (HP:0100559)1.69535199
147Arterial thrombosis (HP:0004420)1.68656800
148Stomatitis (HP:0010280)1.68250176
149Pulmonary infiltrates (HP:0002113)1.67904946
150Broad face (HP:0000283)1.67883911
151Shallow orbits (HP:0000586)1.67010714
152Lower limb amyotrophy (HP:0007210)1.66665815
153Germ cell neoplasia (HP:0100728)1.66245586
154Generalized hypopigmentation of hair (HP:0011358)1.66224723
155Bone pain (HP:0002653)1.64752688
156Vasculitis (HP:0002633)1.64252734
157Ulnar claw (HP:0001178)1.63850913
158Pathologic fracture (HP:0002756)1.63514623
159Myotonia (HP:0002486)1.63177788
160Aqueductal stenosis (HP:0002410)1.62855001
161Hypercortisolism (HP:0001578)1.62519420
162Urinary glycosaminoglycan excretion (HP:0003541)1.60740005
163Mucopolysacchariduria (HP:0008155)1.60740005
164Abdominal distention (HP:0003270)1.60683795
165Spastic paraplegia (HP:0001258)1.60579668
166Cortical dysplasia (HP:0002539)1.60370181
167Bowel incontinence (HP:0002607)1.60073800
168Increased IgM level (HP:0003496)1.60073728
169Follicular hyperkeratosis (HP:0007502)1.60067721
170Autoamputation (HP:0001218)1.59423500
171Obsessive-compulsive behavior (HP:0000722)1.59308317
172Abnormal large intestine physiology (HP:0012700)1.59207837
173Complete atrioventricular canal defect (HP:0001674)1.54973255
174Microglossia (HP:0000171)1.54770000
175Septate vagina (HP:0001153)1.54264585
176Spastic gait (HP:0002064)1.52286704
177Colitis (HP:0002583)1.51908596
178Lymphedema (HP:0001004)1.50074543
179Partial agenesis of the corpus callosum (HP:0001338)1.49103532
180Low anterior hairline (HP:0000294)1.48997512

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.95738320
2NEK62.83864615
3RPS6KB22.76310110
4PDK22.73253189
5EEF2K2.71571261
6MAP3K142.68384317
7TGFBR22.58185392
8MAP3K92.45899234
9PRPF4B2.42445044
10EIF2AK12.38684388
11DDR22.37894877
12TBK12.12806564
13KSR22.06912760
14EIF2AK31.98972033
15ERBB31.97989788
16BRD41.95408777
17CDK121.94640895
18NTRK11.93105189
19IRAK31.83371962
20MINK11.77195736
21MAP3K131.75308908
22SIK31.73337749
23MST1R1.68640006
24MARK11.65611569
25MATK1.64222940
26SMG11.63387881
27BLK1.63241735
28CDK61.59809721
29PBK1.56310023
30BRSK21.56282702
31STK391.53898254
32JAK11.52961225
33SIK11.51692093
34IRAK41.48926381
35PLK21.46124628
36TYK21.43351625
37SIK21.37910410
38MKNK11.31807913
39RIPK11.31198698
40GRK71.30780614
41NEK91.29550255
42MAP3K21.29392084
43LATS21.29114411
44SCYL21.27590308
45CAMK1D1.27536897
46ARAF1.24639036
47PKN21.22097309
48WEE11.21011164
49NTRK31.20979879
50MAP3K121.19956569
51TSSK61.18961241
52FGFR31.17970128
53IKBKE1.16186745
54MAP2K21.14987648
55CAMKK11.14618500
56KSR11.12762702
57ICK1.10810987
58CAMKK21.10147872
59RET1.08938462
60JAK31.08911040
61TRPM71.07924909
62BMPR21.06655523
63RPS6KB11.03643130
64TTK1.03449884
65DAPK21.02732509
66GRK51.00719908
67FRK0.97983337
68EIF2AK20.97130733
69NEK10.96687185
70OXSR10.95629527
71CAMK1G0.95302904
72CSF1R0.94975616
73PDGFRA0.93891843
74ACVR1B0.93175634
75MARK30.91159708
76MOS0.90467258
77ALK0.90432583
78MTOR0.89087926
79PIM20.86573202
80EPHB20.86518495
81EPHA30.86110112
82BMX0.85799027
83YES10.84047126
84AKT30.83415168
85JAK20.83201318
86MAP2K10.79266230
87CCNB10.78649396
88CLK10.78394850
89RPS6KA20.77998463
90PTK2B0.77703171
91PDGFRB0.77699990
92FES0.77101742
93CSK0.75730869
94EPHA40.75565449
95HCK0.75405998
96PRKCH0.74300954
97STK30.73398855
98TRIB30.73201334
99MAP2K30.73061610
100IKBKB0.72243975
101BRSK10.71446524
102TAF10.70434761
103PDK10.69757440
104PDPK10.69451012
105LIMK10.68830866
106STK240.68557652
107FGR0.66978863
108ZAP700.64896160
109IRAK20.64863714
110MAP3K10.64789358
111FER0.63357099
112MAPK100.62825125
113SRPK10.62443891
114NME20.62431735
115TIE10.61269336
116MAPKAPK50.60770923
117KIT0.59743303
118RAF10.58894459
119TTN0.58766093
120EPHB10.58492128
121DMPK0.56921577
122EGFR0.55528854
123SYK0.55341341
124MKNK20.55237422
125CDK50.55115931
126MAP3K100.54232311
127CHEK20.54043648
128CDK70.53737659
129PRKCE0.52675223
130MAP3K50.52209774
131IGF1R0.50382685
132LATS10.49727663
133ABL20.49312278
134WNK10.49004886
135BCR0.48875558
136SGK30.46870609
137PIK3CA0.46074445
138LCK0.45996529
139MAP3K60.45925206
140TEC0.45532975
141ABL10.45431925
142FYN0.45113728
143SRC0.44649553
144MST40.43744615
145MELK0.43669096
146MAPK130.42711875
147CHUK0.42492040
148BRAF0.41093717
149SGK20.40942071
150FGFR40.40189354
151BMPR1B0.39900500
152LYN0.38696097
153MAP3K40.38260104
154MAPK110.37740236
155MAPK120.37315131
156CDC70.37189529
157RPS6KA40.36385029
158ATR0.36027355
159ATM0.35383402
160CHEK10.35332832
161CDK10.34480767
162CAMK2B0.34405979
163PTK60.33309139

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051402.18603762
2Thyroid cancer_Homo sapiens_hsa052162.13667565
3Non-small cell lung cancer_Homo sapiens_hsa052232.09318741
4Acute myeloid leukemia_Homo sapiens_hsa052211.96201764
5Pertussis_Homo sapiens_hsa051331.85802596
6Osteoclast differentiation_Homo sapiens_hsa043801.85402315
7Toll-like receptor signaling pathway_Homo sapiens_hsa046201.82662809
8mTOR signaling pathway_Homo sapiens_hsa041501.70085020
9Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.69792144
10Staphylococcus aureus infection_Homo sapiens_hsa051501.64426505
11Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.62718083
12Tuberculosis_Homo sapiens_hsa051521.62405891
13Malaria_Homo sapiens_hsa051441.56896819
14Phosphatidylinositol signaling system_Homo sapiens_hsa040701.56031429
15Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.55998977
16Salmonella infection_Homo sapiens_hsa051321.55116575
17Graft-versus-host disease_Homo sapiens_hsa053321.51231936
18Rheumatoid arthritis_Homo sapiens_hsa053231.50966971
19Inositol phosphate metabolism_Homo sapiens_hsa005621.48258948
20TNF signaling pathway_Homo sapiens_hsa046681.41247556
21Legionellosis_Homo sapiens_hsa051341.38986314
22Phagosome_Homo sapiens_hsa041451.38420853
23AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.33445868
24Thyroid hormone signaling pathway_Homo sapiens_hsa049191.33102996
25Toxoplasmosis_Homo sapiens_hsa051451.32929433
26Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.30975615
27NOD-like receptor signaling pathway_Homo sapiens_hsa046211.28682152
28African trypanosomiasis_Homo sapiens_hsa051431.28508538
29Central carbon metabolism in cancer_Homo sapiens_hsa052301.21945881
30Lysosome_Homo sapiens_hsa041421.21845973
31Chemokine signaling pathway_Homo sapiens_hsa040621.21695526
32Longevity regulating pathway - mammal_Homo sapiens_hsa042111.19504837
33Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.18279049
34Cell cycle_Homo sapiens_hsa041101.18166571
35Viral carcinogenesis_Homo sapiens_hsa052031.17469312
36Bladder cancer_Homo sapiens_hsa052191.16653865
37Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.15702171
38Neurotrophin signaling pathway_Homo sapiens_hsa047221.15012508
39Olfactory transduction_Homo sapiens_hsa047401.14707091
40Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.14500733
41B cell receptor signaling pathway_Homo sapiens_hsa046621.13055780
42Influenza A_Homo sapiens_hsa051641.13040293
43Amoebiasis_Homo sapiens_hsa051461.11443011
44Non-homologous end-joining_Homo sapiens_hsa034501.10602741
45Prion diseases_Homo sapiens_hsa050201.09736682
46Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.08538069
47Synaptic vesicle cycle_Homo sapiens_hsa047211.07459754
48Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.06572727
49Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.05855449
50Viral myocarditis_Homo sapiens_hsa054161.05330196
51Choline metabolism in cancer_Homo sapiens_hsa052311.04238331
52Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.01688290
53Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.01477637
54Glioma_Homo sapiens_hsa052141.00984581
55Dorso-ventral axis formation_Homo sapiens_hsa043201.00566175
56NF-kappa B signaling pathway_Homo sapiens_hsa040641.00152195
57MicroRNAs in cancer_Homo sapiens_hsa052060.99556962
58Measles_Homo sapiens_hsa051620.99556470
59Platelet activation_Homo sapiens_hsa046110.98838532
60Insulin signaling pathway_Homo sapiens_hsa049100.98794757
61Chronic myeloid leukemia_Homo sapiens_hsa052200.97316953
62Small cell lung cancer_Homo sapiens_hsa052220.97225247
63Prostate cancer_Homo sapiens_hsa052150.96684727
64Type I diabetes mellitus_Homo sapiens_hsa049400.96466043
65Glycosaminoglycan degradation_Homo sapiens_hsa005310.95041785
66Cholinergic synapse_Homo sapiens_hsa047250.94979081
67RNA transport_Homo sapiens_hsa030130.93768617
68T cell receptor signaling pathway_Homo sapiens_hsa046600.92727101
69RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.92162935
70Alcoholism_Homo sapiens_hsa050340.90115435
71Focal adhesion_Homo sapiens_hsa045100.89954874
72Hepatitis B_Homo sapiens_hsa051610.89003359
73mRNA surveillance pathway_Homo sapiens_hsa030150.88962856
74Allograft rejection_Homo sapiens_hsa053300.88773375
75ECM-receptor interaction_Homo sapiens_hsa045120.88331529
76Renin secretion_Homo sapiens_hsa049240.88144127
77Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.88078099
78FoxO signaling pathway_Homo sapiens_hsa040680.87994625
79Pancreatic cancer_Homo sapiens_hsa052120.87739979
80Systemic lupus erythematosus_Homo sapiens_hsa053220.86894378
81Shigellosis_Homo sapiens_hsa051310.86398127
82Long-term potentiation_Homo sapiens_hsa047200.85990849
83Sphingolipid signaling pathway_Homo sapiens_hsa040710.85294275
84GnRH signaling pathway_Homo sapiens_hsa049120.84696559
85Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.84008437
86Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.83549274
87Estrogen signaling pathway_Homo sapiens_hsa049150.82550245
88Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.82268968
89Salivary secretion_Homo sapiens_hsa049700.81627250
90Proteoglycans in cancer_Homo sapiens_hsa052050.81438763
91Type II diabetes mellitus_Homo sapiens_hsa049300.81076989
92Hematopoietic cell lineage_Homo sapiens_hsa046400.79879411
93Cocaine addiction_Homo sapiens_hsa050300.77369672
94Apoptosis_Homo sapiens_hsa042100.77272925
95Dopaminergic synapse_Homo sapiens_hsa047280.77133852
96Prolactin signaling pathway_Homo sapiens_hsa049170.76984093
97Leukocyte transendothelial migration_Homo sapiens_hsa046700.76281766
98Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.75962871
99Circadian entrainment_Homo sapiens_hsa047130.75762630
100VEGF signaling pathway_Homo sapiens_hsa043700.75090669
101Colorectal cancer_Homo sapiens_hsa052100.74753958
102Morphine addiction_Homo sapiens_hsa050320.74612509
103Rap1 signaling pathway_Homo sapiens_hsa040150.74295802
104Long-term depression_Homo sapiens_hsa047300.72825559
105Phospholipase D signaling pathway_Homo sapiens_hsa040720.71883014
106Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.70233256
107Endocytosis_Homo sapiens_hsa041440.69873121
108ErbB signaling pathway_Homo sapiens_hsa040120.69695803
109Oxytocin signaling pathway_Homo sapiens_hsa049210.69429715
110Regulation of actin cytoskeleton_Homo sapiens_hsa048100.69076829
111Oocyte meiosis_Homo sapiens_hsa041140.68318927
112Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.68117667
113Endometrial cancer_Homo sapiens_hsa052130.67629344
114Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.67116939
115Antigen processing and presentation_Homo sapiens_hsa046120.66466730
116Renal cell carcinoma_Homo sapiens_hsa052110.65846195
117Jak-STAT signaling pathway_Homo sapiens_hsa046300.65481315
118Other glycan degradation_Homo sapiens_hsa005110.65422036
119MAPK signaling pathway_Homo sapiens_hsa040100.65098519
120Serotonergic synapse_Homo sapiens_hsa047260.64760485
121Gap junction_Homo sapiens_hsa045400.64706154
122Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.64235243
123Hepatitis C_Homo sapiens_hsa051600.63789262
124Asthma_Homo sapiens_hsa053100.63780580
125Adherens junction_Homo sapiens_hsa045200.63739262
126HIF-1 signaling pathway_Homo sapiens_hsa040660.63083068
127Insulin resistance_Homo sapiens_hsa049310.62604134
128Melanoma_Homo sapiens_hsa052180.62325376
129Aldosterone synthesis and secretion_Homo sapiens_hsa049250.61162644
130Pentose phosphate pathway_Homo sapiens_hsa000300.60623241
131cGMP-PKG signaling pathway_Homo sapiens_hsa040220.60216907
132Gastric acid secretion_Homo sapiens_hsa049710.58770319
133Adipocytokine signaling pathway_Homo sapiens_hsa049200.58376490
134Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.58145657
135Herpes simplex infection_Homo sapiens_hsa051680.56477384
136Nitrogen metabolism_Homo sapiens_hsa009100.55465660
137AMPK signaling pathway_Homo sapiens_hsa041520.55336517
138DNA replication_Homo sapiens_hsa030300.53671025
139Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.53220613
140HTLV-I infection_Homo sapiens_hsa051660.52905361

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