ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	5.36032011
2	respiratory chain complex IV assembly (GO:0008535)	4.94942797
3	cytochrome complex assembly (GO:0017004)	4.47898465
4	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.26225556
5	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	4.20107886
6	proteasome assembly (GO:0043248)	4.18575242
7	protein complex biogenesis (GO:0070271)	4.12966665
8	rRNA modification (GO:0000154)	3.97335443
9	cytidine deamination (GO:0009972)	3.93077808
10	cytidine metabolic process (GO:0046087)	3.93077808
11	cytidine catabolic process (GO:0006216)	3.93077808
12	mitochondrial respiratory chain complex assembly (GO:0033108)	3.91918300
13	pseudouridine synthesis (GO:0001522)	3.90378846
14	regulation of cellular amino acid metabolic process (GO:0006521)	3.80385908
15	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.78127452
16	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.78127452
17	NADH dehydrogenase complex assembly (GO:0010257)	3.78127452
18	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	3.63119770
19	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.57721625
20	cullin deneddylation (GO:0010388)	3.56622879
21	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	3.54047358
22	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	3.54047358
23	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	3.54047358
24	protein deneddylation (GO:0000338)	3.53524347
25	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	3.52675954
26	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	3.52675954
27	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.50504222
28	deoxyribonucleotide catabolic process (GO:0009264)	3.46742699
29	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.46255774
30	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.46255774
31	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	3.44759074
32	iron-sulfur cluster assembly (GO:0016226)	3.44286498
33	metallo-sulfur cluster assembly (GO:0031163)	3.44286498
34	deoxyribonucleoside triphosphate metabolic process (GO:0009200)	3.40023645
35	positive regulation of prostaglandin secretion (GO:0032308)	3.38635266
36	protein targeting to mitochondrion (GO:0006626)	3.37285155
37	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.35383949
38	signal transduction involved in DNA integrity checkpoint (GO:0072401)	3.35171811
39	signal transduction involved in DNA damage checkpoint (GO:0072422)	3.35171811
40	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.31672661
41	signal transduction involved in cell cycle checkpoint (GO:0072395)	3.31668730
42	pyrimidine ribonucleoside catabolic process (GO:0046133)	3.31380416
43	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	3.28805040
44	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.28423696
45	base-excision repair, AP site formation (GO:0006285)	3.27609305
46	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.27396220
47	deoxyribose phosphate catabolic process (GO:0046386)	3.27058061
48	negative regulation of ligase activity (GO:0051352)	3.23286872
49	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	3.23286872
50	DNA damage response, detection of DNA damage (GO:0042769)	3.21845744
51	protein-cofactor linkage (GO:0018065)	3.21727980
52	chaperone-mediated protein transport (GO:0072321)	3.21507243
53	establishment of protein localization to mitochondrion (GO:0072655)	3.19758907
54	platelet dense granule organization (GO:0060155)	3.17163297
55	purine-containing compound salvage (GO:0043101)	3.13622017
56	L-fucose catabolic process (GO:0042355)	3.11832703
57	fucose catabolic process (GO:0019317)	3.11832703
58	L-fucose metabolic process (GO:0042354)	3.11832703
59	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.11231694
60	ribosome assembly (GO:0042255)	3.07695083
61	electron transport chain (GO:0022900)	3.07266927
62	regulation of mitochondrial translation (GO:0070129)	3.05715358
63	respiratory electron transport chain (GO:0022904)	3.05248069
64	mitochondrial RNA metabolic process (GO:0000959)	3.03884320
65	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.02118591
66	maturation of 5.8S rRNA (GO:0000460)	3.01872400
67	protein localization to mitochondrion (GO:0070585)	3.01364286
68	purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)	3.00440449
69	rRNA methylation (GO:0031167)	3.00277196
70	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	2.99289652
71	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	2.97218593
72	ATP synthesis coupled proton transport (GO:0015986)	2.96873108
73	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.96873108
74	7-methylguanosine mRNA capping (GO:0006370)	2.94599696
75	DNA catabolic process, exonucleolytic (GO:0000738)	2.94188312
76	purine nucleotide salvage (GO:0032261)	2.91566940
77	deoxyribose phosphate metabolic process (GO:0019692)	2.90974934
78	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:	2.90717578
79	tRNA processing (GO:0008033)	2.88339645
80	branched-chain amino acid catabolic process (GO:0009083)	2.87450835
81	mannosylation (GO:0097502)	2.87158841
82	pyrimidine nucleotide catabolic process (GO:0006244)	2.86681962
83	RNA capping (GO:0036260)	2.85677601
84	7-methylguanosine RNA capping (GO:0009452)	2.85677601
85	L-methionine salvage (GO:0071267)	2.83324427
86	L-methionine biosynthetic process (GO:0071265)	2.83324427
87	amino acid salvage (GO:0043102)	2.83324427
88	positive regulation of ligase activity (GO:0051351)	2.80738260
89	deoxyribonucleotide metabolic process (GO:0009262)	2.80195719
90	termination of RNA polymerase III transcription (GO:0006386)	2.79985650
91	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.79985650
92	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	2.79693863
93	tRNA metabolic process (GO:0006399)	2.77011266
94	DNA damage response, signal transduction by p53 class mediator (GO:0030330)	2.76951403
95	GTP biosynthetic process (GO:0006183)	2.76085821
96	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.74851172
97	protein neddylation (GO:0045116)	2.73978674
98	regulation of cellular amine metabolic process (GO:0033238)	2.73494029
99	positive regulation of cell cycle arrest (GO:0071158)	2.73081255
100	nucleobase biosynthetic process (GO:0046112)	2.70279413

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	5.40657499
2	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	4.61157326
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.52959358
4	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	4.03497813
5	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.86428384
6	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.76772579
7	ETS1_20019798_ChIP-Seq_JURKAT_Human	3.43294503
8	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.13462700
9	VDR_23849224_ChIP-Seq_CD4+_Human	3.01391672
10	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.86416738
11	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.69021775
12	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.59634529
13	FOXP3_21729870_ChIP-Seq_TREG_Human	2.56980241
14	E2F7_22180533_ChIP-Seq_HELA_Human	2.52153769
15	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.49312183
16	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	2.41102292
17	ELK1_19687146_ChIP-ChIP_HELA_Human	2.36265463
18	ZNF274_21170338_ChIP-Seq_K562_Hela	2.31286002
19	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.23823490
20	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.21391880
21	DCP1A_22483619_ChIP-Seq_HELA_Human	2.16612894
22	GABP_19822575_ChIP-Seq_HepG2_Human	2.16042143
23	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.13895763
24	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	2.13846201
25	HOXB4_20404135_ChIP-ChIP_EML_Mouse	2.04810233
26	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	2.03722953
27	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	2.00622514
28	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.94513382
29	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.89833884
30	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.89260527
31	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.87801077
32	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.83930237
33	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.83396803
34	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.81071800
35	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.80273700
36	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.78570759
37	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.78033776
38	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.75720544
39	TTF2_22483619_ChIP-Seq_HELA_Human	1.67807783
40	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.66888402
41	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.66197823
42	MYC_18940864_ChIP-ChIP_HL60_Human	1.63262415
43	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.61433778
44	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.60281198
45	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.59993168
46	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.59189078
47	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.57633221
48	KDM5A_27292631_Chip-Seq_BREAST_Human	1.54166607
49	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.47403370
50	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.45790912
51	TP53_22573176_ChIP-Seq_HFKS_Human	1.42946182
52	CIITA_25753668_ChIP-Seq_RAJI_Human	1.40174018
53	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.37966053
54	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.35560019
55	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.35045211
56	XRN2_22483619_ChIP-Seq_HELA_Human	1.32155281
57	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.28994107
58	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.25222270
59	VDR_22108803_ChIP-Seq_LS180_Human	1.25105986
60	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.24414621
61	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	1.23687553
62	ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.20372942
63	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.20235440
64	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.18083256
65	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.09968763
66	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.07351755
67	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.06650320
68	GATA3_26560356_Chip-Seq_TH2_Human	1.05962694
69	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.04742926
70	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.02513707
71	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.01065308
72	IGF1R_20145208_ChIP-Seq_DFB_Human	1.00714973
73	IRF8_21731497_ChIP-ChIP_J774_Mouse	0.99216645
74	TFEB_21752829_ChIP-Seq_HELA_Human	0.96730118
75	MYC_19079543_ChIP-ChIP_MESCs_Mouse	0.96253431
76	SPI1_23547873_ChIP-Seq_NB4_Human	0.96183354
77	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.94991244
78	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.94560140
79	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	0.94253970
80	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	0.94130492
81	AR_20517297_ChIP-Seq_VCAP_Human	0.93758274
82	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.91484389
83	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	0.89069425
84	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.88499353
85	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.88499353
86	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.86204653
87	GFI1B_20887958_ChIP-Seq_HPC-7_Mouse	0.85550837
88	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	0.85091070
89	CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse	0.83921796
90	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.83532504
91	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	0.82947368
92	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.80748225
93	IRF1_19129219_ChIP-ChIP_H3396_Human	0.80688414
94	EWS_26573619_Chip-Seq_HEK293_Human	0.79932355
95	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.79478189
96	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	0.79230093
97	ERA_21632823_ChIP-Seq_H3396_Human	0.78884952
98	HTT_18923047_ChIP-ChIP_STHdh_Human	0.77336708
99	NCOR_22424771_ChIP-Seq_293T_Human	0.77330924
100	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.76630526

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	3.12806310
2	MP0008058_abnormal_DNA_repair	2.96554173
3	MP0003806_abnormal_nucleotide_metabolis	2.88558252
4	MP0003693_abnormal_embryo_hatching	2.76506329
5	MP0003195_calcinosis	2.55682156
6	MP0005084_abnormal_gallbladder_morpholo	2.46173551
7	MP0006036_abnormal_mitochondrial_physio	2.44304612
8	MP0002102_abnormal_ear_morphology	2.40376892
9	MP0005671_abnormal_response_to	2.33965986
10	MP0000372_irregular_coat_pigmentation	2.24982160
11	MP0003786_premature_aging	2.11571520
12	MP0003718_maternal_effect	2.09973343
13	MP0008875_abnormal_xenobiotic_pharmacok	2.06522684
14	MP0005075_abnormal_melanosome_morpholog	2.04054308
15	MP0006072_abnormal_retinal_apoptosis	1.96927161
16	MP0002837_dystrophic_cardiac_calcinosis	1.93929412
17	MP0001835_abnormal_antigen_presentation	1.89636374
18	MP0003646_muscle_fatigue	1.89458528
19	MP0010094_abnormal_chromosome_stability	1.89305709
20	MP0004957_abnormal_blastocyst_morpholog	1.87917469
21	MP0003186_abnormal_redox_activity	1.87400388
22	MP0003787_abnormal_imprinting	1.86154922
23	MP0002163_abnormal_gland_morphology	1.75689769
24	MP0001764_abnormal_homeostasis	1.73167175
25	MP0002148_abnormal_hypersensitivity_rea	1.72482899
26	MP0009697_abnormal_copulation	1.72466026
27	MP0008872_abnormal_physiological_respon	1.71611621
28	MP0004147_increased_porphyrin_level	1.68396931
29	MP0009785_altered_susceptibility_to	1.63396821
30	MP0008007_abnormal_cellular_replicative	1.59172192
31	MP0006035_abnormal_mitochondrial_morpho	1.56914354
32	MP0001986_abnormal_taste_sensitivity	1.52471741
33	MP0005636_abnormal_mineral_homeostasis	1.50457522
34	MP0005645_abnormal_hypothalamus_physiol	1.50368621
35	MP0005379_endocrine/exocrine_gland_phen	1.45542341
36	MP0003172_abnormal_lysosome_physiology	1.41415853
37	MP0002876_abnormal_thyroid_physiology	1.41246137
38	MP0008057_abnormal_DNA_replication	1.37773100
39	MP0003111_abnormal_nucleus_morphology	1.36800014
40	MP0002693_abnormal_pancreas_physiology	1.31638098
41	MP0009333_abnormal_splenocyte_physiolog	1.30867197
42	MP0001661_extended_life_span	1.29945520
43	MP0002736_abnormal_nociception_after	1.28455188
44	MP0005410_abnormal_fertilization	1.24745760
45	MP0005551_abnormal_eye_electrophysiolog	1.18590076
46	MP0008932_abnormal_embryonic_tissue	1.18104803
47	MP0005646_abnormal_pituitary_gland	1.17014420
48	MP0001968_abnormal_touch/_nociception	1.16256007
49	MP0001984_abnormal_olfaction	1.15491342
50	MP0000689_abnormal_spleen_morphology	1.15233451
51	MP0005000_abnormal_immune_tolerance	1.14654435
52	MP0001790_abnormal_immune_system	1.14569793
53	MP0005387_immune_system_phenotype	1.14569793
54	MP0009764_decreased_sensitivity_to	1.12466730
55	MP0001800_abnormal_humoral_immune	1.11773387
56	MP0001727_abnormal_embryo_implantation	1.07060309
57	MP0002723_abnormal_immune_serum	1.06989584
58	MP0009046_muscle_twitch	1.04554073
59	MP0003763_abnormal_thymus_physiology	1.03104016
60	MP0005266_abnormal_metabolism	1.01927830
61	MP0001929_abnormal_gametogenesis	1.01239923
62	MP0005253_abnormal_eye_physiology	0.98862994
63	MP0005332_abnormal_amino_acid	0.97407861
64	MP0000358_abnormal_cell_content/	0.95970617
65	MP0001529_abnormal_vocalization	0.95916263
66	MP0001873_stomach_inflammation	0.95039908
67	MP0005389_reproductive_system_phenotype	0.94990671
68	MP0009840_abnormal_foam_cell	0.92830970
69	MP0000685_abnormal_immune_system	0.92289766
70	MP0002420_abnormal_adaptive_immunity	0.92209603
71	MP0002398_abnormal_bone_marrow	0.91213350
72	MP0005584_abnormal_enzyme/coenzyme_acti	0.91176264
73	MP0002132_abnormal_respiratory_system	0.89930411
74	MP0002452_abnormal_antigen_presenting	0.89449874
75	MP0002722_abnormal_immune_system	0.88038886
76	MP0001819_abnormal_immune_cell	0.88034858
77	MP0005025_abnormal_response_to	0.86702759
78	MP0002210_abnormal_sex_determination	0.85668695
79	MP0001845_abnormal_inflammatory_respons	0.85202357
80	MP0004043_abnormal_pH_regulation	0.84926814
81	MP0002138_abnormal_hepatobiliary_system	0.83492279
82	MP0002405_respiratory_system_inflammati	0.82776245
83	MP0001853_heart_inflammation	0.82459775
84	MP0003011_delayed_dark_adaptation	0.82412231
85	MP0002019_abnormal_tumor_incidence	0.81511119
86	MP0002095_abnormal_skin_pigmentation	0.81312047
87	MP0003121_genomic_imprinting	0.80935130
88	MP0006292_abnormal_olfactory_placode	0.80442046
89	MP0002139_abnormal_hepatobiliary_system	0.80174020
90	MP0005220_abnormal_exocrine_pancreas	0.79231329
91	MP0001919_abnormal_reproductive_system	0.78904468
92	MP0002429_abnormal_blood_cell	0.78889804
93	MP0000716_abnormal_immune_system	0.78431717
94	MP0002160_abnormal_reproductive_system	0.78383623
95	MP0008789_abnormal_olfactory_epithelium	0.77604781
96	MP0002277_abnormal_respiratory_mucosa	0.75490474
97	MP0008995_early_reproductive_senescence	0.75367423
98	MP0001119_abnormal_female_reproductive	0.74979875
99	MP0003077_abnormal_cell_cycle	0.74468470
100	MP0005464_abnormal_platelet_physiology	0.74286464

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormal mitochondria in muscle tissue (HP:0008316)	4.59004312
2	Acute necrotizing encephalopathy (HP:0006965)	4.58350134
3	Hepatocellular necrosis (HP:0001404)	4.55605823
4	Hepatic necrosis (HP:0002605)	4.45205635
5	Mitochondrial inheritance (HP:0001427)	4.42556710
6	Increased CSF lactate (HP:0002490)	4.21680573
7	Acute encephalopathy (HP:0006846)	4.07709306
8	Progressive macrocephaly (HP:0004481)	4.03143115
9	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	3.53189941
10	Decreased activity of mitochondrial respiratory chain (HP:0008972)	3.53189941
11	Cerebral edema (HP:0002181)	3.21165905
12	Lactic acidosis (HP:0003128)	3.17175434
13	Aplastic anemia (HP:0001915)	3.14163550
14	Increased serum lactate (HP:0002151)	3.10338148
15	Type I transferrin isoform profile (HP:0003642)	3.05540940
16	3-Methylglutaconic aciduria (HP:0003535)	3.03177079
17	Stomatitis (HP:0010280)	3.01668968
18	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.92303007
19	Increased intramyocellular lipid droplets (HP:0012240)	2.87715202
20	Dicarboxylic aciduria (HP:0003215)	2.85760726
21	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.85760726
22	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.84177981
23	Reduced antithrombin III activity (HP:0001976)	2.79985589
24	Respiratory failure (HP:0002878)	2.77510479
25	Severe combined immunodeficiency (HP:0004430)	2.66497250
26	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.65177894
27	Abnormal protein N-linked glycosylation (HP:0012347)	2.65177894
28	Abnormal protein glycosylation (HP:0012346)	2.65177894
29	Abnormal glycosylation (HP:0012345)	2.65177894
30	Increased hepatocellular lipid droplets (HP:0006565)	2.64428548
31	Exercise intolerance (HP:0003546)	2.59656993
32	Lipid accumulation in hepatocytes (HP:0006561)	2.58585622
33	Microvesicular hepatic steatosis (HP:0001414)	2.58281778
34	Ketoacidosis (HP:0001993)	2.58076814
35	Renal cortical cysts (HP:0000803)	2.52172391
36	Generalized aminoaciduria (HP:0002909)	2.51663527
37	Methylmalonic acidemia (HP:0002912)	2.50228681
38	Optic disc pallor (HP:0000543)	2.45577866
39	Methylmalonic aciduria (HP:0012120)	2.45045367
40	Increased muscle lipid content (HP:0009058)	2.44441999
41	Renal Fanconi syndrome (HP:0001994)	2.39619371
42	Congenital stationary night blindness (HP:0007642)	2.35905853
43	Ketosis (HP:0001946)	2.34042183
44	Hypoglycemic coma (HP:0001325)	2.33876963
45	IgG deficiency (HP:0004315)	2.30125895
46	Lethargy (HP:0001254)	2.27986985
47	Hypothermia (HP:0002045)	2.27793369
48	Abnormality of midbrain morphology (HP:0002418)	2.21926681
49	Molar tooth sign on MRI (HP:0002419)	2.21926681
50	Pancytopenia (HP:0001876)	2.21513579
51	Agammaglobulinemia (HP:0004432)	2.20268522
52	Hypoglycemic seizures (HP:0002173)	2.14832978
53	Combined immunodeficiency (HP:0005387)	2.13974574
54	Hyperinsulinemic hypoglycemia (HP:0000825)	2.13434335
55	Progressive microcephaly (HP:0000253)	2.11466709
56	CNS demyelination (HP:0007305)	2.10760975
57	Thyroiditis (HP:0100646)	2.07693798
58	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.05120258
59	Hypoproteinemia (HP:0003075)	2.04710404
60	Emotional lability (HP:0000712)	1.99761093
61	Pancreatic cysts (HP:0001737)	1.98410576
62	Abnormality of the renal cortex (HP:0011035)	1.95522149
63	Attenuation of retinal blood vessels (HP:0007843)	1.93410155
64	Large for gestational age (HP:0001520)	1.92645072
65	Petechiae (HP:0000967)	1.90949565
66	Hypomagnesemia (HP:0002917)	1.87448181
67	Multiple enchondromatosis (HP:0005701)	1.85423797
68	Cerebral palsy (HP:0100021)	1.83622079
69	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.83211151
70	Symptomatic seizures (HP:0011145)	1.83064337
71	Type 2 muscle fiber atrophy (HP:0003554)	1.80247080
72	Abnormal rod and cone electroretinograms (HP:0008323)	1.78427612
73	Acute hepatic failure (HP:0006554)	1.78360043
74	Posterior subcapsular cataract (HP:0007787)	1.77952237
75	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.77524335
76	Abnormality of alanine metabolism (HP:0010916)	1.77524335
77	Hyperalaninemia (HP:0003348)	1.77524335
78	Glycosuria (HP:0003076)	1.76537038
79	Abnormality of urine glucose concentration (HP:0011016)	1.76537038
80	Elevated erythrocyte sedimentation rate (HP:0003565)	1.76500683
81	Leukodystrophy (HP:0002415)	1.76425057
82	Prominent metopic ridge (HP:0005487)	1.76279356
83	Ragged-red muscle fibers (HP:0003200)	1.76134931
84	Abnormality of endocrine pancreas physiology (HP:0012093)	1.76044323
85	Abnormality of the pancreatic islet cells (HP:0006476)	1.76044323
86	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.75529420
87	Panhypogammaglobulinemia (HP:0003139)	1.74628043
88	Degeneration of anterior horn cells (HP:0002398)	1.74460004
89	Abnormality of the anterior horn cell (HP:0006802)	1.74460004
90	Tongue fasciculations (HP:0001308)	1.74324677
91	Aplasia/hypoplasia of the uterus (HP:0008684)	1.73938595
92	Progressive inability to walk (HP:0002505)	1.72811603
93	Pancreatic islet-cell hyperplasia (HP:0004510)	1.72453338
94	Palpitations (HP:0001962)	1.72196262
95	Abnormality of methionine metabolism (HP:0010901)	1.69266188
96	Abnormality of the pons (HP:0007361)	1.69037103
97	Muscle fiber atrophy (HP:0100295)	1.67357242
98	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.66979149
99	Abnormality of T cell physiology (HP:0011840)	1.64004568
100	Abnormality of T cells (HP:0002843)	1.63322604

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TESK2	4.86923512
2	BCKDK	3.44573878
3	VRK2	3.03475995
4	NUAK1	2.95665714
5	MST4	2.79618339
6	MAP4K2	2.67947772
7	TRIM28	2.61257395
8	EIF2AK3	2.54364056
9	KDR	2.52603483
10	TXK	2.27840477
11	EIF2AK1	2.18865055
12	PBK	2.09330922
13	BUB1	2.04954864
14	ZAK	2.03610205
15	STK16	1.93199646
16	NME2	1.93182317
17	MAP3K12	1.79405430
18	FRK	1.69459627
19	SRPK1	1.67872381
20	ADRBK2	1.67221334
21	TSSK6	1.50472957
22	DAPK1	1.49779994
23	INSRR	1.47616149
24	GRK1	1.43617120
25	NME1	1.42929782
26	VRK1	1.38928780
27	MAPKAPK3	1.25564910
28	FLT3	1.19573023
29	TAOK3	1.19149038
30	PLK4	1.16579007
31	PLK3	1.15034215
32	CDC7	1.11089031
33	PDK2	1.10819301
34	IKBKB	1.05156170
35	PIM2	1.02734378
36	MAP3K11	1.01053405
37	CSNK1G3	0.98760721
38	TLK1	0.97189843
39	BMPR1B	0.92307916
40	TESK1	0.86423134
41	WNK3	0.85043602
42	ITK	0.84599001
43	CSNK1G1	0.84562384
44	CSNK1A1L	0.84248949
45	SIK3	0.84089356
46	LIMK1	0.83724756
47	CCNB1	0.82088612
48	NEK1	0.82066362
49	ACVR1B	0.80162922
50	ATR	0.77751031
51	DYRK2	0.73306565
52	TEC	0.72581691
53	ABL2	0.71351058
54	GRK7	0.70614890
55	PLK2	0.70346346
56	SCYL2	0.64300582
57	PLK1	0.62828447
58	CSNK1G2	0.60824960
59	CLK1	0.60373956
60	RPS6KA5	0.59961592
61	PHKG1	0.59556333
62	PHKG2	0.59556333
63	PRKCI	0.58457333
64	MATK	0.58248704
65	TTK	0.57598049
66	MAP2K7	0.56528177
67	PINK1	0.55369500
68	AURKA	0.53866519
69	PRKCQ	0.51733092
70	KIT	0.50978358
71	MAP4K1	0.49955264
72	OXSR1	0.49590087
73	DAPK2	0.49565039
74	CSNK2A1	0.49429306
75	WNK4	0.48921608
76	BCR	0.48138138
77	CSNK2A2	0.46920125
78	STK3	0.46571147
79	PRKCE	0.46276789
80	BMPR2	0.45449701
81	IRAK3	0.45381439
82	ATM	0.45156312
83	STK10	0.44435046
84	MUSK	0.43970735
85	SYK	0.42254904
86	BRSK2	0.40960314
87	IRAK1	0.39095213
88	PIK3CG	0.38634753
89	LYN	0.37865909
90	AURKB	0.37812451
91	ADRBK1	0.37574821
92	ALK	0.36871648
93	GRK6	0.33933594
94	EIF2AK2	0.33836271
95	LCK	0.32581894
96	CSNK1A1	0.31441769
97	CHEK2	0.31080432
98	LATS1	0.29089624
99	CAMKK2	0.28946350
100	PRKCA	0.25856650

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	4.59460572
2	Protein export_Homo sapiens_hsa03060	3.14140807
3	Oxidative phosphorylation_Homo sapiens_hsa00190	3.01287637
4	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.76836396
5	RNA polymerase_Homo sapiens_hsa03020	2.49803759
6	Parkinsons disease_Homo sapiens_hsa05012	2.42293395
7	Sulfur metabolism_Homo sapiens_hsa00920	2.38537620
8	DNA replication_Homo sapiens_hsa03030	2.23617332
9	Mismatch repair_Homo sapiens_hsa03430	2.20825336
10	Base excision repair_Homo sapiens_hsa03410	2.08620601
11	Homologous recombination_Homo sapiens_hsa03440	2.04811470
12	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.99379573
13	Fatty acid elongation_Homo sapiens_hsa00062	1.96048664
14	Primary immunodeficiency_Homo sapiens_hsa05340	1.90512308
15	Pyrimidine metabolism_Homo sapiens_hsa00240	1.86422942
16	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.84961163
17	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.75015992
18	One carbon pool by folate_Homo sapiens_hsa00670	1.67277240
19	Fanconi anemia pathway_Homo sapiens_hsa03460	1.66826055
20	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.60220562
21	Nucleotide excision repair_Homo sapiens_hsa03420	1.57097067
22	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.53110673
23	Butanoate metabolism_Homo sapiens_hsa00650	1.50761303
24	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.49149026
25	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.48430185
26	Huntingtons disease_Homo sapiens_hsa05016	1.47444134
27	Propanoate metabolism_Homo sapiens_hsa00640	1.46508785
28	Non-homologous end-joining_Homo sapiens_hsa03450	1.46421174
29	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.45940660
30	Basal transcription factors_Homo sapiens_hsa03022	1.44494311
31	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.43777210
32	RNA degradation_Homo sapiens_hsa03018	1.41947941
33	Collecting duct acid secretion_Homo sapiens_hsa04966	1.40356807
34	RNA transport_Homo sapiens_hsa03013	1.38949150
35	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.38071306
36	Phototransduction_Homo sapiens_hsa04744	1.36248380
37	Alzheimers disease_Homo sapiens_hsa05010	1.34523747
38	Purine metabolism_Homo sapiens_hsa00230	1.32509484
39	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.24694925
40	Spliceosome_Homo sapiens_hsa03040	1.24541474
41	Selenocompound metabolism_Homo sapiens_hsa00450	1.23213901
42	Peroxisome_Homo sapiens_hsa04146	1.20973825
43	Ribosome_Homo sapiens_hsa03010	1.19685521
44	Regulation of autophagy_Homo sapiens_hsa04140	1.17083538
45	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.16266542
46	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.08984786
47	Type I diabetes mellitus_Homo sapiens_hsa04940	1.07523547
48	Antigen processing and presentation_Homo sapiens_hsa04612	1.06600669
49	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.06581794
50	Rheumatoid arthritis_Homo sapiens_hsa05323	1.04239428
51	Tryptophan metabolism_Homo sapiens_hsa00380	1.00616924
52	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.94677500
53	Glutathione metabolism_Homo sapiens_hsa00480	0.86896327
54	Fatty acid metabolism_Homo sapiens_hsa01212	0.84283660
55	Asthma_Homo sapiens_hsa05310	0.82084854
56	Folate biosynthesis_Homo sapiens_hsa00790	0.81003751
57	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.78815353
58	Metabolic pathways_Homo sapiens_hsa01100	0.76702529
59	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.74410241
60	Carbon metabolism_Homo sapiens_hsa01200	0.74236888
61	Allograft rejection_Homo sapiens_hsa05330	0.73551400
62	Pyruvate metabolism_Homo sapiens_hsa00620	0.73306690
63	Fatty acid degradation_Homo sapiens_hsa00071	0.72179193
64	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.71980825
65	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.71589275
66	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.67811462
67	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.67518264
68	Cardiac muscle contraction_Homo sapiens_hsa04260	0.66455289
69	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.66034276
70	Graft-versus-host disease_Homo sapiens_hsa05332	0.64855545
71	Steroid biosynthesis_Homo sapiens_hsa00100	0.64521657
72	Caffeine metabolism_Homo sapiens_hsa00232	0.61309744
73	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.59915048
74	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.59175731
75	Pentose phosphate pathway_Homo sapiens_hsa00030	0.55682669
76	Vibrio cholerae infection_Homo sapiens_hsa05110	0.55165073
77	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.50342780
78	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.48137511
79	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.42957114
80	beta-Alanine metabolism_Homo sapiens_hsa00410	0.42750833
81	Nitrogen metabolism_Homo sapiens_hsa00910	0.42084258
82	Chemical carcinogenesis_Homo sapiens_hsa05204	0.41072162
83	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.40801188
84	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.39796354
85	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.38684177
86	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.38309310
87	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.35989740
88	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.35753610
89	Ether lipid metabolism_Homo sapiens_hsa00565	0.34375979
90	Legionellosis_Homo sapiens_hsa05134	0.34168885
91	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.31202513
92	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.29742055
93	Galactose metabolism_Homo sapiens_hsa00052	0.29382504
94	mRNA surveillance pathway_Homo sapiens_hsa03015	0.29164449
95	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.27603943
96	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.27561002
97	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.26945697
98	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.24685808
99	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.23912072
100	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.23303522

FAM103A2P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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