FAM104A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)6.41849912
2viral transcription (GO:0019083)5.39941183
3ribosomal small subunit assembly (GO:0000028)5.29342822
4translational termination (GO:0006415)5.25825045
5maturation of SSU-rRNA (GO:0030490)4.90728750
6SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.75326855
7translational elongation (GO:0006414)4.73593426
8ribosomal small subunit biogenesis (GO:0042274)4.73592898
9cotranslational protein targeting to membrane (GO:0006613)4.63538740
10protein targeting to ER (GO:0045047)4.63134886
11protoporphyrinogen IX metabolic process (GO:0046501)4.48039728
12translational initiation (GO:0006413)4.41850125
13establishment of protein localization to endoplasmic reticulum (GO:0072599)4.40146379
14protein localization to endoplasmic reticulum (GO:0070972)4.37380684
15ribosomal large subunit biogenesis (GO:0042273)4.30720186
16cellular protein complex disassembly (GO:0043624)4.17500820
17viral life cycle (GO:0019058)4.16371133
18nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.13287822
19proteasome assembly (GO:0043248)3.99455856
20hepatocyte apoptotic process (GO:0097284)3.95633317
21protein complex disassembly (GO:0043241)3.70695202
22DNA strand elongation involved in DNA replication (GO:0006271)3.65072776
23telomere maintenance via semi-conservative replication (GO:0032201)3.62114479
24translation (GO:0006412)3.61790419
25DNA replication checkpoint (GO:0000076)3.59086040
26ribonucleoprotein complex biogenesis (GO:0022613)3.54159582
27macromolecular complex disassembly (GO:0032984)3.54045144
28protoporphyrinogen IX biosynthetic process (GO:0006782)3.46664639
29deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.44318709
30pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.42453827
31DNA strand elongation (GO:0022616)3.42176009
32neutrophil activation involved in immune response (GO:0002283)3.40847759
33positive regulation of granulocyte differentiation (GO:0030854)3.33457891
34DNA replication initiation (GO:0006270)3.31070256
35rRNA processing (GO:0006364)3.31065459
36termination of RNA polymerase III transcription (GO:0006386)3.28291662
37transcription elongation from RNA polymerase III promoter (GO:0006385)3.28291662
38deoxyribose phosphate biosynthetic process (GO:0046385)3.26491031
392-deoxyribonucleotide biosynthetic process (GO:0009265)3.26491031
40deoxyribonucleotide biosynthetic process (GO:0009263)3.25250983
41regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.24927393
42negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.23506332
43nuclear-transcribed mRNA catabolic process (GO:0000956)3.23387243
44mitotic metaphase plate congression (GO:0007080)3.22475487
45pseudouridine synthesis (GO:0001522)3.21864842
46rRNA metabolic process (GO:0016072)3.21781786
47anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.21665597
48heme biosynthetic process (GO:0006783)3.19360279
49telomere maintenance via recombination (GO:0000722)3.19134252
507-methylguanosine mRNA capping (GO:0006370)3.18639791
51L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.16992213
52protein targeting to membrane (GO:0006612)3.15795501
53spliceosomal snRNP assembly (GO:0000387)3.14484969
54rRNA modification (GO:0000154)3.13266882
55Arp2/3 complex-mediated actin nucleation (GO:0034314)3.13129118
56regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.13075575
57rRNA methylation (GO:0031167)3.11925371
58formation of translation preinitiation complex (GO:0001731)3.10178065
59exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.09984002
60RNA capping (GO:0036260)3.09313882
617-methylguanosine RNA capping (GO:0009452)3.09313882
62mRNA catabolic process (GO:0006402)3.08984807
63positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.07738205
64antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.04149882
65negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.02948146
66negative regulation of ligase activity (GO:0051352)3.02948146
67positive regulation of gamma-delta T cell activation (GO:0046645)3.02079242
68RNA catabolic process (GO:0006401)2.99296173
69GTP biosynthetic process (GO:0006183)2.98917359
70DNA replication-dependent nucleosome organization (GO:0034723)2.95631640
71DNA replication-dependent nucleosome assembly (GO:0006335)2.95631640
72nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.94348708
73spermatid nucleus differentiation (GO:0007289)2.93608494
74transcription-coupled nucleotide-excision repair (GO:0006283)2.93516168
75guanosine-containing compound biosynthetic process (GO:1901070)2.92480409
76chromatin remodeling at centromere (GO:0031055)2.91693741
77CENP-A containing nucleosome assembly (GO:0034080)2.88790307
78positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.86970663
79ribosome biogenesis (GO:0042254)2.86786915
80pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.85946928
81cellular component biogenesis (GO:0044085)2.85507128
82single strand break repair (GO:0000012)2.84597061
83deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.83600221
84UTP biosynthetic process (GO:0006228)2.83301776
85ribosome assembly (GO:0042255)2.83153259
86folic acid-containing compound biosynthetic process (GO:0009396)2.82984542
87kinetochore assembly (GO:0051382)2.82728678
88regulation of B cell receptor signaling pathway (GO:0050855)2.82082068
89hemoglobin metabolic process (GO:0020027)2.81842460
90positive regulation of ligase activity (GO:0051351)2.81286514
91telomere maintenance via telomere lengthening (GO:0010833)2.81207990
92purine-containing compound salvage (GO:0043101)2.80990805
93erythrocyte maturation (GO:0043249)2.80580870
94antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.80496964
95DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.79151302
96protein complex localization (GO:0031503)2.79149631
97histone mRNA metabolic process (GO:0008334)2.78969185
98spliceosomal complex assembly (GO:0000245)2.77711780
99polyamine biosynthetic process (GO:0006596)2.76009376
100protein localization to chromosome, centromeric region (GO:0071459)2.75301645
101mitotic recombination (GO:0006312)2.74037176
102protein K6-linked ubiquitination (GO:0085020)2.73219726
103tetrapyrrole biosynthetic process (GO:0033014)2.72788577
104protein K11-linked ubiquitination (GO:0070979)2.72755965
105piRNA metabolic process (GO:0034587)2.72673906
106nucleobase-containing small molecule interconversion (GO:0015949)2.72597385
107transcription elongation from RNA polymerase II promoter (GO:0006368)2.71883332
108signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.71316477
109intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.71316477
110positive regulation of B cell differentiation (GO:0045579)2.70987635
111ncRNA 3-end processing (GO:0043628)2.70450808
112nucleotide-excision repair, DNA gap filling (GO:0006297)2.69931952
113signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.69308820
114signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.69308820
115signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.69308820
116histone mRNA catabolic process (GO:0071044)2.69295638
117porphyrin-containing compound biosynthetic process (GO:0006779)2.68402782
118antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.67534841
119regulation of ubiquitin-protein transferase activity (GO:0051438)2.65896643
120DNA replication-independent nucleosome organization (GO:0034724)2.65773276
121DNA replication-independent nucleosome assembly (GO:0006336)2.65773276
122neutrophil activation (GO:0042119)2.65424589
123signal transduction involved in DNA integrity checkpoint (GO:0072401)2.64088851
124signal transduction involved in DNA damage checkpoint (GO:0072422)2.64088851
125regulation of cellular amino acid metabolic process (GO:0006521)2.63071851
126regulation of ligase activity (GO:0051340)2.62064537
127heme metabolic process (GO:0042168)2.61172720
128signal transduction involved in cell cycle checkpoint (GO:0072395)2.59818897
129negative regulation of cell killing (GO:0031342)2.58633173
130negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.58633173
131porphyrin-containing compound metabolic process (GO:0006778)2.50115592
132actin nucleation (GO:0045010)2.46980002
133tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.45123725
134RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.45123725
135pyrimidine nucleotide catabolic process (GO:0006244)2.45068977
136granulocyte activation (GO:0036230)2.43415684
137neutrophil mediated immunity (GO:0002446)2.43152454
138myeloid cell development (GO:0061515)2.41160849
139positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.39464805
140histone exchange (GO:0043486)2.39178187
141oxygen transport (GO:0015671)2.38654833
142microtubule depolymerization (GO:0007019)2.37701371
143negative regulation of execution phase of apoptosis (GO:1900118)2.33569716
144regulation of meiosis I (GO:0060631)2.33298474
145positive regulation of DNA recombination (GO:0045911)2.31587841
146metaphase plate congression (GO:0051310)2.30969261
147erythrocyte development (GO:0048821)2.28940513
148DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.28501119
149negative regulation of necroptotic process (GO:0060546)2.28478144
150positive regulation of alpha-beta T cell proliferation (GO:0046641)2.28464243
151protein neddylation (GO:0045116)2.27652549
152regulation of platelet aggregation (GO:0090330)2.26106803
153establishment of chromosome localization (GO:0051303)2.25036465
154antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.24900761
155positive regulation of cell cycle arrest (GO:0071158)2.24899278
156negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.23232939
157deoxyribose phosphate catabolic process (GO:0046386)2.22999620
158positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.21079811
159deoxyribonucleotide metabolic process (GO:0009262)2.20877717
160protein K11-linked deubiquitination (GO:0035871)2.20851877
161cytidine metabolic process (GO:0046087)2.20486477
162cytidine catabolic process (GO:0006216)2.20486477
163cytidine deamination (GO:0009972)2.20486477
164myeloid leukocyte mediated immunity (GO:0002444)2.20261997
165deoxyribose phosphate metabolic process (GO:0019692)2.20171622

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.76564938
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.18132789
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.04331127
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.33262757
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.09658837
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.07334257
7ETS1_20019798_ChIP-Seq_JURKAT_Human2.99138384
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.90280901
9MYC_18358816_ChIP-ChIP_MESCs_Mouse2.86334611
10MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.81004287
11CREB1_15753290_ChIP-ChIP_HEK293T_Human2.77847353
12FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.76358413
13FOXM1_23109430_ChIP-Seq_U2OS_Human2.73926973
14MYC_19079543_ChIP-ChIP_MESCs_Mouse2.61424380
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.57121330
16MYC_19030024_ChIP-ChIP_MESCs_Mouse2.53720519
17XRN2_22483619_ChIP-Seq_HELA_Human2.45026991
18E2F4_17652178_ChIP-ChIP_JURKAT_Human2.42782808
19HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.41013829
20VDR_23849224_ChIP-Seq_CD4+_Human2.35584551
21SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.29149460
22DCP1A_22483619_ChIP-Seq_HELA_Human2.20369253
23SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.10295520
24ELF1_17652178_ChIP-ChIP_JURKAT_Human2.07471296
25IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.05048619
26* GABP_19822575_ChIP-Seq_HepG2_Human2.04327589
27FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.02917571
28TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.02536822
29CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.02063506
30HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.98405013
31E2F1_18555785_ChIP-Seq_MESCs_Mouse1.98219925
32NELFA_20434984_ChIP-Seq_ESCs_Mouse1.96050647
33CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.85094139
34TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.84018360
35FOXP3_21729870_ChIP-Seq_TREG_Human1.81973564
36IRF8_21731497_ChIP-ChIP_J774_Mouse1.81949505
37TTF2_22483619_ChIP-Seq_HELA_Human1.80517111
38IRF8_22096565_ChIP-ChIP_GC-B_Human1.80205168
39CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.79309582
40* MYB_26560356_Chip-Seq_TH2_Human1.78974507
41GATA1_22025678_ChIP-Seq_K562_Human1.77868443
42FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.76860569
43THAP11_20581084_ChIP-Seq_MESCs_Mouse1.76600160
44MYCN_18555785_ChIP-Seq_MESCs_Mouse1.69444748
45PADI4_21655091_ChIP-ChIP_MCF-7_Human1.63859475
46ZFX_18555785_ChIP-Seq_MESCs_Mouse1.63790629
47MYC_22102868_ChIP-Seq_BL_Human1.63562990
48FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.63075719
49E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.57531751
50* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.56778670
51SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.54662468
52DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.52165290
53SRF_21415370_ChIP-Seq_HL-1_Mouse1.52096068
54YY1_21170310_ChIP-Seq_MESCs_Mouse1.51564524
55ERG_20887958_ChIP-Seq_HPC-7_Mouse1.46018544
56PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.45433471
57E2F1_21310950_ChIP-Seq_MCF-7_Human1.45358270
58NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.43924391
59HOXB4_20404135_ChIP-ChIP_EML_Mouse1.43317375
60MYB_26560356_Chip-Seq_TH1_Human1.43234230
61STAT4_19710469_ChIP-ChIP_TH1__Mouse1.43167343
62MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.42483809
63TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.41603708
64NANOG_18555785_ChIP-Seq_MESCs_Mouse1.40178451
65CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.39021460
66* KDM5A_27292631_Chip-Seq_BREAST_Human1.37959199
67STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.37715683
68VDR_21846776_ChIP-Seq_THP-1_Human1.34674563
69SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.31680444
70KLF4_18555785_ChIP-Seq_MESCs_Mouse1.30589783
71CIITA_25753668_ChIP-Seq_RAJI_Human1.30140042
72ELK1_19687146_ChIP-ChIP_HELA_Human1.29636476
73NOTCH1_21737748_ChIP-Seq_TLL_Human1.28881788
74ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.28757551
75CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.28574480
76SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.25213873
77POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.24870760
78EGR1_19374776_ChIP-ChIP_THP-1_Human1.24422579
79ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.24039028
80BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.21971886
81SPI1_23547873_ChIP-Seq_NB4_Human1.21428637
82GATA3_26560356_Chip-Seq_TH2_Human1.17882400
83* GATA3_27048872_Chip-Seq_THYMUS_Human1.17192399
84ELK1_22589737_ChIP-Seq_MCF10A_Human1.16630243
85E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.15538626
86AR_21909140_ChIP-Seq_LNCAP_Human1.15022060
87SRY_22984422_ChIP-ChIP_TESTIS_Rat1.14430756
88SALL4_22934838_ChIP-ChIP_CD34+_Human1.12448000
89PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.11307019
90CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.11256921
91PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.11075606
92GATA2_22383799_ChIP-Seq_G1ME_Mouse1.09929596
93STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.09337735
94STAT3_1855785_ChIP-Seq_MESCs_Mouse1.08376797
95RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.06900500
96TFEB_21752829_ChIP-Seq_HELA_Human1.05351528
97MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.05263887
98GATA1_22383799_ChIP-Seq_G1ME_Mouse1.04915441
99HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.04905953
100KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.04717769
101BRD4_27068464_Chip-Seq_AML-cells_Mouse1.04140655
102MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.04096762
103GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.02679348
104SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.02360513
105HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.00729734
106CTCF_18555785_ChIP-Seq_MESCs_Mouse0.99319241
107CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.99140009
108ZNF263_19887448_ChIP-Seq_K562_Human0.98491324
109FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.97812378
110KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.97661271
111SMAD_19615063_ChIP-ChIP_OVARY_Human0.96450489
112Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.96109584
113TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.95618293
114RUNX1_22412390_ChIP-Seq_EML_Mouse0.95028615
115* YY1_22570637_ChIP-Seq_MALME-3M_Human0.95015240
116EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.94170092
117RUNX_20019798_ChIP-Seq_JUKART_Human0.93923939
118MAF_26560356_Chip-Seq_TH1_Human0.93666369
119CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.93467533
120* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93143303
121KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.92944552
122MAF_26560356_Chip-Seq_TH2_Human0.92446771
123MYC_18940864_ChIP-ChIP_HL60_Human0.90054364
124MYB_21317192_ChIP-Seq_ERMYB_Mouse0.89279669
125MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.89083690
126PU.1_20513432_ChIP-Seq_Bcells_Mouse0.87888026
127KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.87845889
128TBX5_21415370_ChIP-Seq_HL-1_Mouse0.87832356
129YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.87476670
130SCL_19346495_ChIP-Seq_HPC-7_Human0.87436112
131UTX_26944678_Chip-Seq_JUKART_Human0.86892382

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.16099985
2MP0004957_abnormal_blastocyst_morpholog3.51132638
3MP0003111_abnormal_nucleus_morphology3.39289364
4MP0010094_abnormal_chromosome_stability3.20201032
5MP0005464_abnormal_platelet_physiology3.10299355
6MP0003077_abnormal_cell_cycle3.09033949
7MP0003656_abnormal_erythrocyte_physiolo2.68928031
8MP0003646_muscle_fatigue2.59500534
9MP0008007_abnormal_cellular_replicative2.50066592
10MP0008058_abnormal_DNA_repair2.38004267
11MP0002653_abnormal_ependyma_morphology2.34010665
12MP0005075_abnormal_melanosome_morpholog2.31144603
13MP0008932_abnormal_embryonic_tissue2.30687816
14MP0005410_abnormal_fertilization2.27524042
15MP0002163_abnormal_gland_morphology2.13755307
16MP0009333_abnormal_splenocyte_physiolog2.12405135
17MP0000490_abnormal_crypts_of2.00276459
18MP0003123_paternal_imprinting1.98564498
19MP0000015_abnormal_ear_pigmentation1.97457393
20MP0005397_hematopoietic_system_phenotyp1.93164334
21MP0001545_abnormal_hematopoietic_system1.93164334
22MP0003718_maternal_effect1.91494078
23MP0000465_gastrointestinal_hemorrhage1.82086319
24MP0001929_abnormal_gametogenesis1.80986422
25MP0003806_abnormal_nucleotide_metabolis1.79744783
26MP0003786_premature_aging1.79309160
27MP0008877_abnormal_DNA_methylation1.73997473
28MP0002396_abnormal_hematopoietic_system1.65495751
29MP0002210_abnormal_sex_determination1.63234326
30MP0000350_abnormal_cell_proliferation1.62458148
31MP0002102_abnormal_ear_morphology1.61767061
32MP0008057_abnormal_DNA_replication1.58800948
33MP0001730_embryonic_growth_arrest1.51819874
34MP0003221_abnormal_cardiomyocyte_apopto1.50095612
35MP0004147_increased_porphyrin_level1.48936777
36MP0000685_abnormal_immune_system1.48556152
37MP0002277_abnormal_respiratory_mucosa1.47618556
38MP0000569_abnormal_digit_pigmentation1.44443819
39MP0002398_abnormal_bone_marrow1.44124767
40MP0002166_altered_tumor_susceptibility1.43896536
41MP0002019_abnormal_tumor_incidence1.41153319
42MP0003186_abnormal_redox_activity1.40745532
43MP0001145_abnormal_male_reproductive1.39774161
44MP0000858_altered_metastatic_potential1.39045529
45MP0000313_abnormal_cell_death1.36661431
46MP0002877_abnormal_melanocyte_morpholog1.35562118
47MP0004808_abnormal_hematopoietic_stem1.34578047
48MP0001697_abnormal_embryo_size1.34167404
49MP0006035_abnormal_mitochondrial_morpho1.31349560
50MP0003315_abnormal_perineum_morphology1.30055624
51MP0001188_hyperpigmentation1.29684578
52MP0000653_abnormal_sex_gland1.27600817
53MP0002419_abnormal_innate_immunity1.27299254
54MP0002722_abnormal_immune_system1.24387898
55MP0000703_abnormal_thymus_morphology1.22370718
56MP0003763_abnormal_thymus_physiology1.21702435
57MP0005174_abnormal_tail_pigmentation1.21675850
58MP0003698_abnormal_male_reproductive1.21082130
59MP0000689_abnormal_spleen_morphology1.20248641
60MP0000358_abnormal_cell_content/1.16768307
61MP0002080_prenatal_lethality1.15930002
62MP0002429_abnormal_blood_cell1.15299938
63MP0008995_early_reproductive_senescence1.13061516
64MP0005084_abnormal_gallbladder_morpholo1.12450151
65MP0005671_abnormal_response_to1.08587294
66MP0009379_abnormal_foot_pigmentation1.08197392
67MP0006054_spinal_hemorrhage1.08057837
68MP0003787_abnormal_imprinting1.06286656
69MP0003436_decreased_susceptibility_to1.06144900
70MP0010030_abnormal_orbit_morphology1.06123357
71MP0006036_abnormal_mitochondrial_physio1.05448288
72MP0000750_abnormal_muscle_regeneration1.05120453
73MP0002006_tumorigenesis1.04103495
74MP0003303_peritoneal_inflammation1.03171170
75MP0005000_abnormal_immune_tolerance1.02417008
76MP0009785_altered_susceptibility_to1.01205484
77MP0002095_abnormal_skin_pigmentation1.00950190
78MP0002085_abnormal_embryonic_tissue1.00620784
79MP0002405_respiratory_system_inflammati1.00500039
80MP0000716_abnormal_immune_system1.00206127
81MP0002132_abnormal_respiratory_system0.98131246
82MP0002452_abnormal_antigen_presenting0.97466502
83MP0002723_abnormal_immune_serum0.97445533
84MP0001819_abnormal_immune_cell0.97028280
85MP0002420_abnormal_adaptive_immunity0.96670749
86MP0005379_endocrine/exocrine_gland_phen0.96657518
87MP0008004_abnormal_stomach_pH0.96320096
88MP0001845_abnormal_inflammatory_respons0.94685863
89MP0009765_abnormal_xenobiotic_induced0.94502552
90MP0001835_abnormal_antigen_presentation0.93886102
91MP0003191_abnormal_cellular_cholesterol0.93113034
92MP0008260_abnormal_autophagy0.92720150
93MP0005380_embryogenesis_phenotype0.92496533
94MP0001672_abnormal_embryogenesis/_devel0.92496533
95MP0002161_abnormal_fertility/fecundity0.92470914
96MP0009763_increased_sensitivity_to0.92413897
97MP0009697_abnormal_copulation0.92341174
98MP0008789_abnormal_olfactory_epithelium0.91527703
99MP0000613_abnormal_salivary_gland0.90872800
100MP0001119_abnormal_female_reproductive0.89600764
101MP0003984_embryonic_growth_retardation0.88300642
102MP0001800_abnormal_humoral_immune0.87543143
103MP0001851_eye_inflammation0.85819707
104MP0005025_abnormal_response_to0.84810227
105MP0002088_abnormal_embryonic_growth/wei0.84606134
106MP0004947_skin_inflammation0.84324654
107MP0002148_abnormal_hypersensitivity_rea0.84082688
108MP0003183_abnormal_peptide_metabolism0.83764859
109MP0005310_abnormal_salivary_gland0.83468737
110MP0005395_other_phenotype0.82864525
111MP0010307_abnormal_tumor_latency0.82655870
112MP0001919_abnormal_reproductive_system0.81555057
113MP0009278_abnormal_bone_marrow0.77848979
114MP0001853_heart_inflammation0.77066579
115MP0000372_irregular_coat_pigmentation0.76415458
116MP0006292_abnormal_olfactory_placode0.76285460
117MP0000678_abnormal_parathyroid_gland0.76268829
118MP0009764_decreased_sensitivity_to0.75420766
119MP0005083_abnormal_biliary_tract0.74400940
120MP0005384_cellular_phenotype0.73029185
121MP0005621_abnormal_cell_physiology0.71258163
122MP0002084_abnormal_developmental_patter0.70444720
123MP0005451_abnormal_body_composition0.70187828
124MP0009840_abnormal_foam_cell0.68932893
125MP0003724_increased_susceptibility_to0.68012314
126MP0005257_abnormal_intraocular_pressure0.67286723
127MP0003699_abnormal_female_reproductive0.66591261
128MP0001293_anophthalmia0.66380817
129MP0003866_abnormal_defecation0.65294714
130MP0002086_abnormal_extraembryonic_tissu0.63036096
131MP0001790_abnormal_immune_system0.62686829
132MP0005387_immune_system_phenotype0.62686829
133MP0002638_abnormal_pupillary_reflex0.62392154

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)5.82751148
2Abnormal number of erythroid precursors (HP:0012131)5.65238863
3Hypochromic microcytic anemia (HP:0004840)4.61302589
4Reticulocytopenia (HP:0001896)4.33409990
5Carpal bone hypoplasia (HP:0001498)4.30802519
6Abnormality of the heme biosynthetic pathway (HP:0010472)4.16666167
7Pallor (HP:0000980)4.02838177
8Decreased activity of mitochondrial respiratory chain (HP:0008972)3.98010672
9Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.98010672
10Macrocytic anemia (HP:0001972)3.91173346
11Aplasia/Hypoplasia of the sacrum (HP:0008517)3.57994586
12Breast hypoplasia (HP:0003187)3.56535000
13Birth length less than 3rd percentile (HP:0003561)3.55306018
14Aplastic anemia (HP:0001915)3.41745208
15Microcytic anemia (HP:0001935)3.31609247
16Prolonged bleeding time (HP:0003010)3.30191338
17Cholecystitis (HP:0001082)3.22965292
18Abnormal gallbladder physiology (HP:0012438)3.22965292
19Fatigue (HP:0012378)3.11564694
20Stomatitis (HP:0010280)3.03920859
21Acute hepatic failure (HP:0006554)2.99937703
22T lymphocytopenia (HP:0005403)2.96969795
23Recurrent bacterial skin infections (HP:0005406)2.92395182
24Muscle fiber atrophy (HP:0100295)2.85568755
25Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.85068888
26Abnormal platelet volume (HP:0011876)2.84493171
27Gingival bleeding (HP:0000225)2.83906433
28Exertional dyspnea (HP:0002875)2.82237618
29Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.82001072
30Cholelithiasis (HP:0001081)2.79966034
31Microretrognathia (HP:0000308)2.79097613
32Increased mean platelet volume (HP:0011877)2.76502150
33Nasal polyposis (HP:0100582)2.75255274
34Poor head control (HP:0002421)2.71730699
35Secondary amenorrhea (HP:0000869)2.71547412
36Epistaxis (HP:0000421)2.69292575
37Rough bone trabeculation (HP:0100670)2.66681324
38Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.64672502
39Papillary thyroid carcinoma (HP:0002895)2.63968583
40Abnormal gallbladder morphology (HP:0012437)2.63290544
41Oral leukoplakia (HP:0002745)2.62358573
42Cerebral hypomyelination (HP:0006808)2.62320086
43Abnormality of T cell number (HP:0011839)2.62124836
44Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.59993395
45Hepatocellular necrosis (HP:0001404)2.59662618
46Increased hepatocellular lipid droplets (HP:0006565)2.57958685
47Trismus (HP:0000211)2.55510916
48IgG deficiency (HP:0004315)2.54812145
49Type 2 muscle fiber atrophy (HP:0003554)2.51406596
50Generalized aminoaciduria (HP:0002909)2.50862460
51Paralysis (HP:0003470)2.46557004
52Premature ovarian failure (HP:0008209)2.44189784
53Cleft eyelid (HP:0000625)2.44142189
54Patellar aplasia (HP:0006443)2.43562975
55Acanthocytosis (HP:0001927)2.43039372
56Mitochondrial inheritance (HP:0001427)2.41022993
57Aplasia/Hypoplasia of the patella (HP:0006498)2.39077525
58Abnormality of reticulocytes (HP:0004312)2.35693307
59Autoimmune hemolytic anemia (HP:0001890)2.35306342
60IgM deficiency (HP:0002850)2.35279623
61Progressive muscle weakness (HP:0003323)2.33013900
62Lipid accumulation in hepatocytes (HP:0006561)2.29604412
63Abnormality of macrophages (HP:0004311)2.28772096
64Degeneration of anterior horn cells (HP:0002398)2.27731022
65Abnormality of the anterior horn cell (HP:0006802)2.27731022
66Abnormality of the nasal mucosa (HP:0000433)2.26302858
67Failure to thrive in infancy (HP:0001531)2.25832348
68Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.25548746
69Increased serum lactate (HP:0002151)2.25001196
70Beaking of vertebral bodies (HP:0004568)2.24500209
71Thyroid carcinoma (HP:0002890)2.23814029
72Petechiae (HP:0000967)2.22790130
73Increased intramyocellular lipid droplets (HP:0012240)2.22692336
74Absent rod-and cone-mediated responses on ERG (HP:0007688)2.22264116
75Eczematoid dermatitis (HP:0000976)2.22158243
76Severe visual impairment (HP:0001141)2.19187405
77Thrombocytosis (HP:0001894)2.18650826
78Respiratory difficulties (HP:0002880)2.15548385
79Hypochromic anemia (HP:0001931)2.15329862
80Abnormality of T cells (HP:0002843)2.14285310
81Urticaria (HP:0001025)2.12220515
82Concave nail (HP:0001598)2.11873499
83Anorexia (HP:0002039)2.11766815
84Leukocytosis (HP:0001974)2.11539958
85Pelvic girdle muscle weakness (HP:0003749)2.11176182
86Granulocytopenia (HP:0001913)2.11015085
87Type I transferrin isoform profile (HP:0003642)2.10889428
88Elevated erythrocyte sedimentation rate (HP:0003565)2.10284335
89Irregular epiphyses (HP:0010582)2.10232149
90Increased CSF lactate (HP:0002490)2.09172697
91Abnormal spermatogenesis (HP:0008669)2.08362569
92Slow saccadic eye movements (HP:0000514)2.07590353
93Personality changes (HP:0000751)2.07577578
94Abnormality of eosinophils (HP:0001879)2.07252571
95Spontaneous hematomas (HP:0007420)2.06182911
96Gastrointestinal infarctions (HP:0005244)2.05646503
97Increased IgM level (HP:0003496)2.03976038
98Short nail (HP:0001799)2.03676661
99Tinnitus (HP:0000360)2.02606204
100Hepatic necrosis (HP:0002605)2.02099231
101Acute necrotizing encephalopathy (HP:0006965)2.01243484
102Nausea (HP:0002018)2.00053391
103Menorrhagia (HP:0000132)1.99828565
104Eosinophilia (HP:0001880)1.98011646
105Abnormality of placental membranes (HP:0011409)1.96944152
106Amniotic constriction ring (HP:0009775)1.96944152
107Hepatosplenomegaly (HP:0001433)1.96907143
108Encephalitis (HP:0002383)1.96603988
109Abnormal mitochondria in muscle tissue (HP:0008316)1.95807108
110Microvesicular hepatic steatosis (HP:0001414)1.95379272
111Pancreatic cysts (HP:0001737)1.94233035
112Chronic bronchitis (HP:0004469)1.91938807
113Myelodysplasia (HP:0002863)1.91796082
114Flat capital femoral epiphysis (HP:0003370)1.91596226
115Conjunctival telangiectasia (HP:0000524)1.91127808
116Abnormal platelet function (HP:0011869)1.90202533
117Impaired platelet aggregation (HP:0003540)1.90202533
118Sparse lateral eyebrow (HP:0005338)1.89761973
119Abnormal rod and cone electroretinograms (HP:0008323)1.89645807
120Hypoplasia of the radius (HP:0002984)1.89535709
121Absent thumb (HP:0009777)1.89509960
122Bronchitis (HP:0012387)1.89354731
123Chest pain (HP:0100749)1.89004916
124Entropion (HP:0000621)1.88903986
125Pulmonary fibrosis (HP:0002206)1.88796846
126Triphalangeal thumb (HP:0001199)1.88706437
127Horseshoe kidney (HP:0000085)1.88675179
1283-Methylglutaconic aciduria (HP:0003535)1.88479245
129Hypoplasia of the capital femoral epiphysis (HP:0003090)1.87995696
130Abnormality of the hip-girdle musculature (HP:0001445)1.87771200
131Abnormality of the musculature of the pelvis (HP:0001469)1.87771200
132Recurrent bronchitis (HP:0002837)1.87632014
133Poikilocytosis (HP:0004447)1.86739222
134Increased muscle lipid content (HP:0009058)1.86012936
135Amaurosis fugax (HP:0100576)1.85941725
136Arterial thrombosis (HP:0004420)1.85402625
137Vertebral compression fractures (HP:0002953)1.85389259
13811 pairs of ribs (HP:0000878)1.83810990
139Premature graying of hair (HP:0002216)1.83693032
140Abnormality of the fetal cardiovascular system (HP:0010948)1.82889098
141Abnormal umbilical cord blood vessels (HP:0011403)1.82889098
142Single umbilical artery (HP:0001195)1.82889098
143Recurrent fungal infections (HP:0002841)1.82452685
144Poikiloderma (HP:0001029)1.81965426
145Abnormality of the prostate (HP:0008775)1.81530390
146Pancytopenia (HP:0001876)1.81310946
147Recurrent abscess formation (HP:0002722)1.80998046
148Cutaneous photosensitivity (HP:0000992)1.80520099
149Autoamputation (HP:0001218)1.80210564
150Lymphoma (HP:0002665)1.79996283
151Cutaneous melanoma (HP:0012056)1.79378580
152Slender long bone (HP:0003100)1.79348557
153Abnormality of the gallbladder (HP:0005264)1.79227631
154Abnormal trabecular bone morphology (HP:0100671)1.78730883
155Cellular immunodeficiency (HP:0005374)1.77170118
156Exercise intolerance (HP:0003546)1.75843332
157Combined immunodeficiency (HP:0005387)1.74411232
158Cerebellar dysplasia (HP:0007033)1.74018303
159Pustule (HP:0200039)1.73760007
160Lymphopenia (HP:0001888)1.73196343
161Hypergonadotropic hypogonadism (HP:0000815)1.72654967
162Abnormal protein glycosylation (HP:0012346)1.72230690
163Abnormal glycosylation (HP:0012345)1.72230690
164Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.72230690
165Abnormal protein N-linked glycosylation (HP:0012347)1.72230690
166Abnormality of alanine metabolism (HP:0010916)1.72050019
167Hyperalaninemia (HP:0003348)1.72050019
168Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.72050019
169Constricted visual fields (HP:0001133)1.71905816
170Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.71809290
171Recurrent skin infections (HP:0001581)1.71329159
172Multiple enchondromatosis (HP:0005701)1.71110983
173Recurrent viral infections (HP:0004429)1.70719184
174Increased density of long bones (HP:0006392)1.70650325
175Emotional lability (HP:0000712)1.69404402
176Meckel diverticulum (HP:0002245)1.66070873
177Delusions (HP:0000746)1.64058731
178Neoplasm of the pancreas (HP:0002894)1.62918525
179Renal Fanconi syndrome (HP:0001994)1.62615345

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME24.22497145
2BUB14.07926925
3TLK13.84028083
4TRIM283.77314629
5EIF2AK13.72559820
6MST43.26650612
7WEE12.84992765
8MAP3K122.78884393
9TESK22.57050999
10PIM22.44615656
11NEK22.37306745
12STK162.37174580
13GRK62.32230853
14TESK12.25194732
15DYRK32.15070348
16PLK42.10830791
17MAP2K31.98665266
18BRAF1.93574200
19MAP3K111.91893922
20CDK81.85855908
21SIK31.83663534
22CDC71.79893259
23MAPKAPK31.75985573
24RPS6KA41.70568243
25MARK31.63573908
26TAOK31.62631677
27VRK11.60032765
28MAP3K31.59118954
29ARAF1.52968089
30ACVR1B1.52915580
31SRPK11.47208310
32PLK21.44252327
33MAP3K101.44213000
34PBK1.42519919
35TEC1.41356352
36FGR1.37947526
37MUSK1.37369940
38TAOK11.34941576
39RIPK41.33463752
40TAOK21.33159413
41PLK11.28957092
42PTK2B1.28846814
43TXK1.28633657
44AURKA1.26806754
45TTK1.26629854
46CHEK21.26333631
47IRAK31.23389646
48KDR1.22973127
49NME11.19050606
50CDK71.14899661
51MAP4K11.14724975
52BRSK21.14111584
53EIF2AK31.12062627
54ABL21.11396297
55AURKB1.07970543
56CDK191.06298075
57MAP3K11.05208794
58BMPR21.03184317
59IRAK41.02836713
60PDK31.00225115
61PDK41.00225115
62RPS6KB20.99092810
63MOS0.98279261
64PRKD30.97723497
65BCR0.96632937
66DYRK20.96047258
67SCYL20.95850550
68LATS20.95622436
69MAP3K80.93010540
70PIM10.91499475
71SYK0.90606838
72STK38L0.89891719
73KIT0.89585881
74BRSK10.89518373
75EEF2K0.88229281
76PIK3CG0.84818649
77CCNB10.84431510
78RPS6KA50.83767048
79CDK40.83644516
80MAPKAPK50.79507367
81PAK10.78483350
82PAK40.76794455
83RAF10.76587272
84STK100.76355399
85KSR10.75366187
86IKBKB0.74452503
87VRK20.74043055
88TBK10.73174142
89ERN10.72154256
90NUAK10.71543423
91FES0.71437082
92MATK0.70128763
93ERBB30.70079357
94CSK0.70040654
95MAP3K140.69969830
96BMPR1B0.69097770
97ATR0.66951738
98STK40.66847086
99CSF1R0.66329948
100MAP2K70.65774560
101GRK50.65746476
102ILK0.64794057
103LYN0.64512158
104FLT30.62666839
105NEK10.61321298
106HCK0.61221501
107DYRK1B0.56703550
108MAP2K20.54368110
109JAK30.54310189
110CSNK2A10.53593977
111LIMK10.53262161
112LRRK20.52958347
113EGFR0.52799254
114BMX0.52012989
115PDK20.51761106
116BLK0.50962751
117LCK0.50274010
118IRAK10.49943090
119ERBB40.49472903
120ITK0.48306314
121ZAP700.47899626
122ZAK0.47785467
123CLK10.47763618
124TYK20.46781634
125MAP4K20.45312336
126EPHB10.43434720
127TSSK60.43348136
128JAK20.42796246
129MAPK110.42506495
130DAPK30.42276595
131BTK0.41846704
132MAP3K50.40698541
133CHEK10.40683110
134STK30.40149681
135NLK0.39645245
136CSNK2A20.39292247
137IRAK20.39162862
138PRKCI0.39123209
139NEK60.37940139
140STK240.37848220
141MAPKAPK20.37602573
142PLK30.35884519
143MAP3K60.35067077
144NEK90.34516158
145IKBKE0.34196541
146EPHA20.32940162
147CDK90.32783868
148MKNK20.32407153
149PRKG20.31993813

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.78831660
2DNA replication_Homo sapiens_hsa030303.91812808
3RNA polymerase_Homo sapiens_hsa030203.55832633
4Proteasome_Homo sapiens_hsa030503.31705013
5Mismatch repair_Homo sapiens_hsa034302.88796759
6Homologous recombination_Homo sapiens_hsa034402.78538952
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.68551338
8Spliceosome_Homo sapiens_hsa030402.68312858
9Pyrimidine metabolism_Homo sapiens_hsa002402.56120031
10Base excision repair_Homo sapiens_hsa034102.51346329
11Nucleotide excision repair_Homo sapiens_hsa034202.36783120
12Cell cycle_Homo sapiens_hsa041102.32026432
13Basal transcription factors_Homo sapiens_hsa030222.31760752
14RNA transport_Homo sapiens_hsa030132.25230897
15Protein export_Homo sapiens_hsa030602.14749481
16RNA degradation_Homo sapiens_hsa030181.90918506
17Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.80575972
18Fanconi anemia pathway_Homo sapiens_hsa034601.68480202
19p53 signaling pathway_Homo sapiens_hsa041151.61101012
20Collecting duct acid secretion_Homo sapiens_hsa049661.50888245
21Purine metabolism_Homo sapiens_hsa002301.47952081
22Sulfur relay system_Homo sapiens_hsa041221.38399899
23Huntingtons disease_Homo sapiens_hsa050161.36254749
24Parkinsons disease_Homo sapiens_hsa050121.36219509
25Oxidative phosphorylation_Homo sapiens_hsa001901.35632099
26Fatty acid elongation_Homo sapiens_hsa000621.35539610
27One carbon pool by folate_Homo sapiens_hsa006701.28471215
28Folate biosynthesis_Homo sapiens_hsa007901.27580136
29Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.22344502
30T cell receptor signaling pathway_Homo sapiens_hsa046601.14584233
31Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.11286978
32Non-homologous end-joining_Homo sapiens_hsa034501.11226076
33Epstein-Barr virus infection_Homo sapiens_hsa051691.10429505
34Herpes simplex infection_Homo sapiens_hsa051681.05618895
35Antigen processing and presentation_Homo sapiens_hsa046121.03834519
36Vitamin B6 metabolism_Homo sapiens_hsa007501.01667672
37mRNA surveillance pathway_Homo sapiens_hsa030150.98410967
38Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.97339684
39Sulfur metabolism_Homo sapiens_hsa009200.97237900
40Systemic lupus erythematosus_Homo sapiens_hsa053220.95046624
41Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.93721324
42Pentose phosphate pathway_Homo sapiens_hsa000300.93374625
43Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.91155259
44Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.90208770
45Osteoclast differentiation_Homo sapiens_hsa043800.86088052
46Non-small cell lung cancer_Homo sapiens_hsa052230.84511011
47Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.83866896
48Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.82874191
49Other glycan degradation_Homo sapiens_hsa005110.79652753
50Bladder cancer_Homo sapiens_hsa052190.78381926
51Legionellosis_Homo sapiens_hsa051340.77721119
52Platelet activation_Homo sapiens_hsa046110.76701771
53Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.76320695
54Type I diabetes mellitus_Homo sapiens_hsa049400.75867750
55Oocyte meiosis_Homo sapiens_hsa041140.74841929
56Shigellosis_Homo sapiens_hsa051310.74734432
57Phagosome_Homo sapiens_hsa041450.74087794
58Allograft rejection_Homo sapiens_hsa053300.73423198
59Thyroid cancer_Homo sapiens_hsa052160.72549239
60Autoimmune thyroid disease_Homo sapiens_hsa053200.72410083
61Viral carcinogenesis_Homo sapiens_hsa052030.72023391
62Endocytosis_Homo sapiens_hsa041440.71296713
63Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.70417875
64Alzheimers disease_Homo sapiens_hsa050100.70370055
65Measles_Homo sapiens_hsa051620.68940226
66HTLV-I infection_Homo sapiens_hsa051660.67716203
67Chemokine signaling pathway_Homo sapiens_hsa040620.66297051
68Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.66000464
69Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.63973460
70Apoptosis_Homo sapiens_hsa042100.63486440
71Hepatitis B_Homo sapiens_hsa051610.61619433
72Acute myeloid leukemia_Homo sapiens_hsa052210.61511510
73Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.60779424
74Hematopoietic cell lineage_Homo sapiens_hsa046400.60391152
75SNARE interactions in vesicular transport_Homo sapiens_hsa041300.57338659
76Primary immunodeficiency_Homo sapiens_hsa053400.56632869
77Vibrio cholerae infection_Homo sapiens_hsa051100.54503895
78Viral myocarditis_Homo sapiens_hsa054160.52103194
79Tuberculosis_Homo sapiens_hsa051520.51981159
80Regulation of autophagy_Homo sapiens_hsa041400.51359547
81Leishmaniasis_Homo sapiens_hsa051400.50437980
82Malaria_Homo sapiens_hsa051440.49185785
83Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.46681393
84Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.46505257
85NF-kappa B signaling pathway_Homo sapiens_hsa040640.45176928
86Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.44450296
87RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.44304852
88Alcoholism_Homo sapiens_hsa050340.43619140
89Influenza A_Homo sapiens_hsa051640.42597910
90Rheumatoid arthritis_Homo sapiens_hsa053230.41407319
91FoxO signaling pathway_Homo sapiens_hsa040680.41321397
92Cysteine and methionine metabolism_Homo sapiens_hsa002700.40898632
93Salmonella infection_Homo sapiens_hsa051320.40216102
94Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.38755244
95Glutathione metabolism_Homo sapiens_hsa004800.38422246
96Linoleic acid metabolism_Homo sapiens_hsa005910.37645121
97Maturity onset diabetes of the young_Homo sapiens_hsa049500.37192323
98Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.36962768
99Chronic myeloid leukemia_Homo sapiens_hsa052200.36578619
100Cardiac muscle contraction_Homo sapiens_hsa042600.36322460
101N-Glycan biosynthesis_Homo sapiens_hsa005100.35114003
102Pancreatic cancer_Homo sapiens_hsa052120.34424036
103HIF-1 signaling pathway_Homo sapiens_hsa040660.32705401
104Jak-STAT signaling pathway_Homo sapiens_hsa046300.31677200
105Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.30933102
106Transcriptional misregulation in cancer_Homo sapiens_hsa052020.30706514
107Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.30209236
108VEGF signaling pathway_Homo sapiens_hsa043700.29397866
109Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.29376625
110B cell receptor signaling pathway_Homo sapiens_hsa046620.29022111
111Arachidonic acid metabolism_Homo sapiens_hsa005900.27534498
112Small cell lung cancer_Homo sapiens_hsa052220.27262011
113Galactose metabolism_Homo sapiens_hsa000520.27205071
114NOD-like receptor signaling pathway_Homo sapiens_hsa046210.25349149
115TGF-beta signaling pathway_Homo sapiens_hsa043500.25099328
116Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.24592332
117Intestinal immune network for IgA production_Homo sapiens_hsa046720.24018768
118Asthma_Homo sapiens_hsa053100.23841055
119Graft-versus-host disease_Homo sapiens_hsa053320.22946707
120Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.22740738
121Selenocompound metabolism_Homo sapiens_hsa004500.22646062
122Toll-like receptor signaling pathway_Homo sapiens_hsa046200.22396159
123Metabolic pathways_Homo sapiens_hsa011000.22216186
124Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.21992290
125Colorectal cancer_Homo sapiens_hsa052100.21413457
126Fructose and mannose metabolism_Homo sapiens_hsa000510.20266524
127Circadian rhythm_Homo sapiens_hsa047100.19871484

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