FAM106A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)5.63323267
2detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)4.21205772
3L-fucose catabolic process (GO:0042355)4.17261633
4fucose catabolic process (GO:0019317)4.17261633
5L-fucose metabolic process (GO:0042354)4.17261633
6response to pheromone (GO:0019236)3.80497379
7negative regulation of mast cell activation (GO:0033004)3.78382022
8epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.73903466
9neural tube formation (GO:0001841)3.71655690
10behavioral response to ethanol (GO:0048149)3.61100887
11postsynaptic membrane organization (GO:0001941)3.38744308
12positive regulation of oligodendrocyte differentiation (GO:0048714)3.36688993
13pyrimidine nucleobase catabolic process (GO:0006208)3.33478623
14negative regulation of telomere maintenance (GO:0032205)3.32810743
15detection of light stimulus involved in visual perception (GO:0050908)3.30476961
16detection of light stimulus involved in sensory perception (GO:0050962)3.30476961
17indolalkylamine metabolic process (GO:0006586)3.27447620
18protein polyglutamylation (GO:0018095)3.26569544
19regulation of action potential (GO:0098900)3.18418686
20negative regulation of cytosolic calcium ion concentration (GO:0051481)3.15668715
21photoreceptor cell maintenance (GO:0045494)3.10417123
22regulation of telomere maintenance (GO:0032204)3.04835242
23DNA deamination (GO:0045006)3.02988110
24centriole replication (GO:0007099)3.02812808
25positive regulation of action potential (GO:0045760)2.97738186
26kynurenine metabolic process (GO:0070189)2.96877755
27adaptation of signaling pathway (GO:0023058)2.96808023
28epithelial cilium movement (GO:0003351)2.96160597
29regulation of cilium movement (GO:0003352)2.94641526
30cellular ketone body metabolic process (GO:0046950)2.93985992
31axoneme assembly (GO:0035082)2.93655455
32reflex (GO:0060004)2.93078914
33regulation of meiosis I (GO:0060631)2.91994732
34synaptic transmission, cholinergic (GO:0007271)2.91781130
35ketone body metabolic process (GO:1902224)2.90888658
36protein-cofactor linkage (GO:0018065)2.89918604
37protein K11-linked deubiquitination (GO:0035871)2.89913241
38neuronal action potential (GO:0019228)2.89440782
39piRNA metabolic process (GO:0034587)2.85587240
40DNA methylation involved in gamete generation (GO:0043046)2.85530087
41tryptophan catabolic process (GO:0006569)2.84995968
42indole-containing compound catabolic process (GO:0042436)2.84995968
43indolalkylamine catabolic process (GO:0046218)2.84995968
44cilium morphogenesis (GO:0060271)2.83873844
45mannosylation (GO:0097502)2.83479834
46ubiquinone metabolic process (GO:0006743)2.78714627
47somite development (GO:0061053)2.76941643
48cilium or flagellum-dependent cell motility (GO:0001539)2.75952917
49tryptophan metabolic process (GO:0006568)2.75101551
50tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.74576070
51RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.74576070
52glycosphingolipid biosynthetic process (GO:0006688)2.71844810
53nonmotile primary cilium assembly (GO:0035058)2.71394910
54platelet dense granule organization (GO:0060155)2.68438783
55nucleobase catabolic process (GO:0046113)2.67923389
56preassembly of GPI anchor in ER membrane (GO:0016254)2.63753894
57presynaptic membrane assembly (GO:0097105)2.63644635
58DNA double-strand break processing (GO:0000729)2.63112775
59detection of mechanical stimulus involved in sensory perception (GO:0050974)2.62299685
60auditory receptor cell stereocilium organization (GO:0060088)2.61834114
61C4-dicarboxylate transport (GO:0015740)2.61207210
62olfactory bulb development (GO:0021772)2.61173741
63reciprocal DNA recombination (GO:0035825)2.60931456
64reciprocal meiotic recombination (GO:0007131)2.60931456
65negative regulation of reactive oxygen species metabolic process (GO:2000378)2.56879641
66cilium organization (GO:0044782)2.56731469
67cilium movement (GO:0003341)2.56457633
68G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.56276159
69ubiquinone biosynthetic process (GO:0006744)2.54236037
70parturition (GO:0007567)2.53885635
71establishment of protein localization to Golgi (GO:0072600)2.53001976
72recombinational repair (GO:0000725)2.52584562
73regulation of collateral sprouting (GO:0048670)2.52265959
74tachykinin receptor signaling pathway (GO:0007217)2.51707367
75transmission of nerve impulse (GO:0019226)2.51689261
76protein complex biogenesis (GO:0070271)2.51224298
77gamma-aminobutyric acid transport (GO:0015812)2.50511773
78double-strand break repair via homologous recombination (GO:0000724)2.50391548
79spinal cord motor neuron differentiation (GO:0021522)2.50268225
80startle response (GO:0001964)2.49311347
81indole-containing compound metabolic process (GO:0042430)2.49160140
82NADH dehydrogenase complex assembly (GO:0010257)2.48716013
83mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.48716013
84mitochondrial respiratory chain complex I assembly (GO:0032981)2.48716013
85acrosome reaction (GO:0007340)2.48651227
86inner ear receptor stereocilium organization (GO:0060122)2.48452255
87central nervous system neuron axonogenesis (GO:0021955)2.47691249
88positive regulation of mitochondrial fission (GO:0090141)2.47436191
89negative regulation of translation, ncRNA-mediated (GO:0040033)2.46968609
90regulation of translation, ncRNA-mediated (GO:0045974)2.46968609
91negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.46968609
92cilium assembly (GO:0042384)2.46900626
93peptidyl-histidine modification (GO:0018202)2.45820554
94auditory behavior (GO:0031223)2.45689184
95cAMP catabolic process (GO:0006198)2.45582319
96cornea development in camera-type eye (GO:0061303)2.44921351
97inositol phosphate catabolic process (GO:0071545)2.44772864
98presynaptic membrane organization (GO:0097090)2.44646468
99dentate gyrus development (GO:0021542)2.44305252
100L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.43574294

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.80904952
2EZH2_22144423_ChIP-Seq_EOC_Human3.41198980
3VDR_22108803_ChIP-Seq_LS180_Human3.40698425
4IGF1R_20145208_ChIP-Seq_DFB_Human3.12930224
5GBX2_23144817_ChIP-Seq_PC3_Human3.09753343
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.02760234
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.71149039
8POU3F2_20337985_ChIP-ChIP_501MEL_Human2.49960059
9SALL1_21062744_ChIP-ChIP_HESCs_Human2.33844809
10CTBP2_25329375_ChIP-Seq_LNCAP_Human2.25255928
11FUS_26573619_Chip-Seq_HEK293_Human2.20005397
12CTBP1_25329375_ChIP-Seq_LNCAP_Human2.13235957
13EWS_26573619_Chip-Seq_HEK293_Human2.10509487
14CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.09358712
15FLI1_27457419_Chip-Seq_LIVER_Mouse2.08250930
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.06481023
17TAF15_26573619_Chip-Seq_HEK293_Human2.03725071
18TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.00450396
19P300_19829295_ChIP-Seq_ESCs_Human1.99652246
20ER_23166858_ChIP-Seq_MCF-7_Human1.95533639
21SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.77115079
22AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.76669121
23PCGF2_27294783_Chip-Seq_ESCs_Mouse1.74708634
24PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.73748519
25HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.71037767
26STAT3_23295773_ChIP-Seq_U87_Human1.69321553
27CBP_20019798_ChIP-Seq_JUKART_Human1.67348303
28IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.67348303
29EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.67330429
30SMAD4_21799915_ChIP-Seq_A2780_Human1.66796525
31BCAT_22108803_ChIP-Seq_LS180_Human1.66221679
32POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.65875625
33TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.65875625
34PCGF2_27294783_Chip-Seq_NPCs_Mouse1.65790739
35UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.63794492
36NOTCH1_21737748_ChIP-Seq_TLL_Human1.59222525
37TCF4_23295773_ChIP-Seq_U87_Human1.58258561
38IRF1_19129219_ChIP-ChIP_H3396_Human1.57778377
39CBX2_27304074_Chip-Seq_ESCs_Mouse1.54382570
40PIAS1_25552417_ChIP-Seq_VCAP_Human1.53859755
41TP53_22573176_ChIP-Seq_HFKS_Human1.52923187
42MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.51786119
43MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.50212017
44MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.49990790
45AR_25329375_ChIP-Seq_VCAP_Human1.48311911
46NR3C1_21868756_ChIP-Seq_MCF10A_Human1.47514844
47SUZ12_27294783_Chip-Seq_NPCs_Mouse1.46028821
48REST_21632747_ChIP-Seq_MESCs_Mouse1.45038527
49BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.44275627
50SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.41013479
51ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.38031601
52SMAD3_21741376_ChIP-Seq_EPCs_Human1.36332475
53HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.35854000
54NFE2_27457419_Chip-Seq_LIVER_Mouse1.35008858
55RUNX2_22187159_ChIP-Seq_PCA_Human1.34626305
56TOP2B_26459242_ChIP-Seq_MCF-7_Human1.33996960
57TCF4_22108803_ChIP-Seq_LS180_Human1.33524187
58KLF5_20875108_ChIP-Seq_MESCs_Mouse1.33516228
59SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31937067
60PRDM14_20953172_ChIP-Seq_ESCs_Human1.27020834
61EZH2_27294783_Chip-Seq_NPCs_Mouse1.26833582
62RNF2_27304074_Chip-Seq_NSC_Mouse1.25238262
63NANOG_19829295_ChIP-Seq_ESCs_Human1.24869057
64SOX2_19829295_ChIP-Seq_ESCs_Human1.24869057
65OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22588995
66FLI1_21867929_ChIP-Seq_TH2_Mouse1.21805176
67BMI1_23680149_ChIP-Seq_NPCS_Mouse1.20025218
68GABP_17652178_ChIP-ChIP_JURKAT_Human1.18665079
69TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.14724230
70TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.13421243
71NANOG_18555785_Chip-Seq_ESCs_Mouse1.13348549
72GATA3_21878914_ChIP-Seq_MCF-7_Human1.12739587
73EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.11568032
74SMAD4_21741376_ChIP-Seq_EPCs_Human1.11496483
75CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.10505054
76AR_21572438_ChIP-Seq_LNCaP_Human1.09832995
77ETV2_25802403_ChIP-Seq_MESCs_Mouse1.08116789
78GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.07837005
79E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.07345738
80ELK1_19687146_ChIP-ChIP_HELA_Human1.06222626
81CRX_20693478_ChIP-Seq_RETINA_Mouse1.05946948
82MYC_18940864_ChIP-ChIP_HL60_Human1.05764120
83P53_22387025_ChIP-Seq_ESCs_Mouse1.05151294
84FOXA1_25329375_ChIP-Seq_VCAP_Human1.04654837
85FOXA1_27270436_Chip-Seq_PROSTATE_Human1.04654837
86NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.02217903
87FOXA1_21572438_ChIP-Seq_LNCaP_Human1.01960990
88AR_20517297_ChIP-Seq_VCAP_Human1.00389233
89CDX2_22108803_ChIP-Seq_LS180_Human1.00054168
90NCOR_22424771_ChIP-Seq_293T_Human0.98997538
91STAT3_18555785_Chip-Seq_ESCs_Mouse0.98273654
92TP53_16413492_ChIP-PET_HCT116_Human0.97735936
93TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.97637541
94TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.97637224
95E2F1_18555785_Chip-Seq_ESCs_Mouse0.97514411
96TAL1_26923725_Chip-Seq_HPCs_Mouse0.97358052
97EST1_17652178_ChIP-ChIP_JURKAT_Human0.96688623
98HOXB7_26014856_ChIP-Seq_BT474_Human0.94226178
99SOX2_21211035_ChIP-Seq_LN229_Gbm0.93779970
100EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.93182179

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002102_abnormal_ear_morphology3.10440941
2MP0003787_abnormal_imprinting2.93054925
3MP0001968_abnormal_touch/_nociception2.87347279
4MP0008877_abnormal_DNA_methylation2.63003834
5MP0006292_abnormal_olfactory_placode2.49153712
6MP0005551_abnormal_eye_electrophysiolog2.34589752
7MP0003136_yellow_coat_color2.33103862
8MP0001986_abnormal_taste_sensitivity2.29867532
9MP0002736_abnormal_nociception_after2.27014833
10MP0003880_abnormal_central_pattern2.22977592
11MP0003646_muscle_fatigue2.17263788
12MP0000569_abnormal_digit_pigmentation2.06664356
13MP0000372_irregular_coat_pigmentation2.06026026
14MP0004885_abnormal_endolymph1.94539588
15MP0002163_abnormal_gland_morphology1.90214512
16MP0006276_abnormal_autonomic_nervous1.84622147
17MP0001529_abnormal_vocalization1.84301728
18MP0005646_abnormal_pituitary_gland1.84113435
19MP0009745_abnormal_behavioral_response1.84107038
20MP0005253_abnormal_eye_physiology1.83174268
21MP0004142_abnormal_muscle_tone1.79845811
22MP0004147_increased_porphyrin_level1.79354973
23MP0006072_abnormal_retinal_apoptosis1.79210374
24MP0003195_calcinosis1.74380172
25MP0001501_abnormal_sleep_pattern1.72916657
26MP0002272_abnormal_nervous_system1.68579691
27MP0000427_abnormal_hair_cycle1.67835989
28MP0001486_abnormal_startle_reflex1.63009331
29MP0008872_abnormal_physiological_respon1.60382406
30MP0002735_abnormal_chemical_nociception1.57459693
31MP0009046_muscle_twitch1.56269404
32MP0001984_abnormal_olfaction1.56067222
33MP0002653_abnormal_ependyma_morphology1.56057827
34MP0002876_abnormal_thyroid_physiology1.55935332
35MP0002638_abnormal_pupillary_reflex1.55243288
36MP0001485_abnormal_pinna_reflex1.53219860
37MP0000778_abnormal_nervous_system1.52629999
38MP0005645_abnormal_hypothalamus_physiol1.52307410
39MP0005174_abnormal_tail_pigmentation1.50636916
40MP0002837_dystrophic_cardiac_calcinosis1.49983507
41MP0008789_abnormal_olfactory_epithelium1.48618537
42MP0004742_abnormal_vestibular_system1.48459036
43MP0004133_heterotaxia1.44677824
44MP0002095_abnormal_skin_pigmentation1.40700817
45MP0000015_abnormal_ear_pigmentation1.39457089
46MP0000631_abnormal_neuroendocrine_gland1.39020262
47MP0002572_abnormal_emotion/affect_behav1.35978510
48MP0005171_absent_coat_pigmentation1.34104816
49MP0004043_abnormal_pH_regulation1.32236271
50MP0005379_endocrine/exocrine_gland_phen1.31836822
51MP0004924_abnormal_behavior1.28968231
52MP0005386_behavior/neurological_phenoty1.28968231
53MP0002234_abnormal_pharynx_morphology1.27295769
54MP0002557_abnormal_social/conspecific_i1.26630255
55MP0008057_abnormal_DNA_replication1.24608220
56MP0003635_abnormal_synaptic_transmissio1.23143618
57MP0001970_abnormal_pain_threshold1.20261202
58MP0002067_abnormal_sensory_capabilities1.19548455
59MP0005187_abnormal_penis_morphology1.18831285
60MP0008995_early_reproductive_senescence1.17347681
61MP0003121_genomic_imprinting1.14862401
62MP0002733_abnormal_thermal_nociception1.12644508
63MP0000647_abnormal_sebaceous_gland1.08668220
64MP0002064_seizures1.07229170
65MP0005377_hearing/vestibular/ear_phenot1.06748133
66MP0003878_abnormal_ear_physiology1.06748133
67MP0002063_abnormal_learning/memory/cond1.06593402
68MP0002160_abnormal_reproductive_system1.06053089
69MP0008775_abnormal_heart_ventricle1.04197956
70MP0002928_abnormal_bile_duct1.04132445
71MP0005499_abnormal_olfactory_system1.01190957
72MP0005394_taste/olfaction_phenotype1.01190957
73MP0001324_abnormal_eye_pigmentation1.00876110
74MP0005195_abnormal_posterior_eye0.99714703
75MP0002734_abnormal_mechanical_nocicepti0.97326371
76MP0005389_reproductive_system_phenotype0.96875716
77MP0002752_abnormal_somatic_nervous0.95923442
78MP0008058_abnormal_DNA_repair0.94303553
79MP0000230_abnormal_systemic_arterial0.92784319
80MP0002184_abnormal_innervation0.91999803
81MP0005075_abnormal_melanosome_morpholog0.91688312
82MP0000383_abnormal_hair_follicle0.91648086
83MP0002938_white_spotting0.90181576
84MP0003718_maternal_effect0.89163724
85MP0000026_abnormal_inner_ear0.89048003
86MP0005167_abnormal_blood-brain_barrier0.88721868
87MP0001905_abnormal_dopamine_level0.88520679
88MP0009697_abnormal_copulation0.87876693
89MP0001963_abnormal_hearing_physiology0.87174553
90MP0002751_abnormal_autonomic_nervous0.86539739
91MP0005084_abnormal_gallbladder_morpholo0.85234304
92MP0003011_delayed_dark_adaptation0.85153273
93MP0003698_abnormal_male_reproductive0.82595258
94MP0003122_maternal_imprinting0.82365898
95MP0005391_vision/eye_phenotype0.82228646
96MP0001502_abnormal_circadian_rhythm0.81776125
97MP0002229_neurodegeneration0.80869944
98MP0002882_abnormal_neuron_morphology0.79798333
99MP0001929_abnormal_gametogenesis0.78796590
100MP0010386_abnormal_urinary_bladder0.77876312

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.48013286
2Pancreatic fibrosis (HP:0100732)4.10350870
3Molar tooth sign on MRI (HP:0002419)3.87747216
4Abnormality of midbrain morphology (HP:0002418)3.87747216
5Nephronophthisis (HP:0000090)3.84583007
6True hermaphroditism (HP:0010459)3.69961438
7Chronic hepatic failure (HP:0100626)3.43542725
8Abnormality of the renal cortex (HP:0011035)3.40343987
9Abnormality of the renal medulla (HP:0100957)3.36044335
10Hyperventilation (HP:0002883)3.32969763
11Type II lissencephaly (HP:0007260)3.31973849
12Congenital stationary night blindness (HP:0007642)3.21271465
13Medial flaring of the eyebrow (HP:0010747)3.07249080
14Attenuation of retinal blood vessels (HP:0007843)3.06616836
15Neoplasm of the adrenal cortex (HP:0100641)2.98448423
16Abolished electroretinogram (ERG) (HP:0000550)2.98389848
17Keratoconus (HP:0000563)2.83065681
18Increased corneal curvature (HP:0100692)2.83065681
19Tubular atrophy (HP:0000092)2.74208794
20Cystic liver disease (HP:0006706)2.65215105
213-Methylglutaconic aciduria (HP:0003535)2.63071403
22Polydipsia (HP:0001959)2.61733146
23Abnormal drinking behavior (HP:0030082)2.61733146
24Gaze-evoked nystagmus (HP:0000640)2.49725830
25Intestinal atresia (HP:0011100)2.45970314
26Stomach cancer (HP:0012126)2.44482063
27Aplasia/Hypoplasia of the tongue (HP:0010295)2.42696575
28Absent rod-and cone-mediated responses on ERG (HP:0007688)2.42339134
29Renal cortical cysts (HP:0000803)2.38140567
30Lissencephaly (HP:0001339)2.36396417
31Abnormal rod and cone electroretinograms (HP:0008323)2.36221607
32Bony spicule pigmentary retinopathy (HP:0007737)2.35570772
33Congenital hepatic fibrosis (HP:0002612)2.34686141
34Focal motor seizures (HP:0011153)2.33650025
35Retinal dysplasia (HP:0007973)2.33538207
36Absent speech (HP:0001344)2.32686742
37Sclerocornea (HP:0000647)2.31803513
38Metaphyseal dysplasia (HP:0100255)2.31658411
39Anencephaly (HP:0002323)2.30665466
40Pendular nystagmus (HP:0012043)2.26388217
41Cerebellar dysplasia (HP:0007033)2.24720468
42Gait imbalance (HP:0002141)2.22871647
43Focal seizures (HP:0007359)2.20533674
44Inability to walk (HP:0002540)2.20099571
45Polyuria (HP:0000103)2.16439611
46Decreased central vision (HP:0007663)2.16168901
47Congenital primary aphakia (HP:0007707)2.15349882
48Aplasia/Hypoplasia of the tibia (HP:0005772)2.12744267
49Bile duct proliferation (HP:0001408)2.12211985
50Abnormal biliary tract physiology (HP:0012439)2.12211985
51Progressive cerebellar ataxia (HP:0002073)2.11347596
52Febrile seizures (HP:0002373)2.10724966
53Abnormality of the labia minora (HP:0012880)2.09920670
54Postaxial foot polydactyly (HP:0001830)2.09719882
55Oligodactyly (hands) (HP:0001180)2.09051127
56Optic nerve hypoplasia (HP:0000609)2.08688236
57Nephrogenic diabetes insipidus (HP:0009806)2.06756657
58Chorioretinal atrophy (HP:0000533)2.05056240
59Thyroiditis (HP:0100646)2.03786064
60Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.00639704
61Abnormality of alanine metabolism (HP:0010916)2.00639704
62Hyperalaninemia (HP:0003348)2.00639704
63Broad-based gait (HP:0002136)1.97816137
64Tubulointerstitial abnormality (HP:0001969)1.97286910
65Colon cancer (HP:0003003)1.94824170
66Abnormality of DNA repair (HP:0003254)1.94639699
67Pachygyria (HP:0001302)1.92954494
68Genital tract atresia (HP:0001827)1.91506386
69Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.88192124
70Optic disc pallor (HP:0000543)1.87417974
71Tubulointerstitial nephritis (HP:0001970)1.84341288
72Patellar aplasia (HP:0006443)1.84224168
73Occipital encephalocele (HP:0002085)1.83697279
74Dandy-Walker malformation (HP:0001305)1.83600812
75Type 2 muscle fiber atrophy (HP:0003554)1.83198305
76Hemiparesis (HP:0001269)1.82463709
77Aplasia/Hypoplasia of the spleen (HP:0010451)1.82209389
78Growth hormone deficiency (HP:0000824)1.82068635
79Progressive inability to walk (HP:0002505)1.81665496
80Postaxial hand polydactyly (HP:0001162)1.80559016
81Aplasia/Hypoplasia of the patella (HP:0006498)1.80051009
82Protruding tongue (HP:0010808)1.79570720
83Decreased electroretinogram (ERG) amplitude (HP:0000654)1.78027108
84Anterior segment dysgenesis (HP:0007700)1.76020829
85Concave nail (HP:0001598)1.75445809
86Hypothermia (HP:0002045)1.75336961
87Hypoplasia of the pons (HP:0012110)1.74343949
88Genetic anticipation (HP:0003743)1.73996712
89Decreased circulating renin level (HP:0003351)1.73283157
90Ectopic kidney (HP:0000086)1.72402413
91Preaxial hand polydactyly (HP:0001177)1.72018401
92Dialeptic seizures (HP:0011146)1.71805054
93Narrow forehead (HP:0000341)1.71397002
94Vaginal atresia (HP:0000148)1.71131711
95Increased CSF lactate (HP:0002490)1.71004303
96Large for gestational age (HP:0001520)1.70997385
97Male pseudohermaphroditism (HP:0000037)1.70600115
98Tubulointerstitial fibrosis (HP:0005576)1.70219922
99Abnormal respiratory motile cilium morphology (HP:0005938)1.68495953
100Abnormal respiratory epithelium morphology (HP:0012253)1.68495953

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.86732969
2MAP4K22.81066833
3ADRBK22.69432574
4BMPR1B2.60898884
5PINK12.58217893
6NUAK12.50409902
7CASK2.26807883
8WNK32.13191910
9MARK12.12359403
10INSRR2.08668432
11ZAK2.08070145
12MAPK132.07613277
13TAOK32.02267115
14CAMKK21.92012082
15ACVR1B1.77216983
16WNK41.66567480
17PNCK1.61728657
18STK391.55650972
19OXSR11.47541518
20MAP3K41.45760882
21PAK31.41712280
22PLK21.41195406
23GRK11.41053259
24DAPK21.38447057
25TRIM281.26250567
26BCR1.24197394
27MKNK21.23896084
28EIF2AK31.17959771
29TXK1.14702767
30AKT31.13898456
31ADRBK11.11504578
32MAP2K71.10075056
33PTK2B1.08357953
34CAMK1G1.02010097
35EPHA41.01722912
36DYRK21.00626989
37CAMK1D1.00116503
38TNIK0.95330217
39PIK3CA0.91447198
40TLK10.91360051
41CSNK1G20.88675301
42PRKCE0.85979840
43TEC0.85215657
44PLK40.84066275
45CAMK10.79118875
46CDK190.79038928
47ERBB30.78787392
48NTRK30.78415059
49TIE10.77578677
50CSNK1A1L0.76958216
51SIK20.76760774
52CSNK1G10.74518221
53PRKCG0.73725028
54CAMK40.73400879
55CSNK1G30.73350851
56STK38L0.70877444
57CDK80.68447458
58STK110.67134488
59IKBKB0.61689048
60MAP3K70.61186187
61NTRK20.59934613
62SGK20.58808621
63MUSK0.57979448
64CAMK2A0.55613643
65PRKCQ0.53080308
66TGFBR10.51924248
67VRK10.51910681
68ATR0.51854320
69PKN10.51455180
70FER0.50439154
71BCKDK0.49757142
72MAP2K60.49462361
73MKNK10.48902031
74DYRK30.48819095
75BRSK20.48009275
76PRKCZ0.46219105
77CAMKK10.46049092
78PLK30.45812799
79CSNK1D0.45137038
80FLT30.43465024
81TNK20.42637020
82PRKAA20.41547810
83ITK0.41348859
84PRKACA0.40102227
85CSNK1A10.39917497
86PHKG10.39293758
87PHKG20.39293758
88ATM0.38445388
89DYRK1A0.37813041
90MAP2K40.37219570
91SGK2230.36608510
92SGK4940.36608510
93MAPKAPK50.35707026
94GRK50.34846569
95MARK30.33995600
96BRD40.33425252
97IRAK10.33243867
98ABL10.33205050
99CCNB10.33087898
100PRKAA10.32840021

Predicted pathways (KEGG)

RankGene SetZ-score
1Taurine and hypotaurine metabolism_Homo sapiens_hsa004303.09742212
2Phototransduction_Homo sapiens_hsa047442.98017275
3Nicotine addiction_Homo sapiens_hsa050332.67237223
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.60105860
5Linoleic acid metabolism_Homo sapiens_hsa005912.51873532
6alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.50116625
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.39268218
8Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.33828974
9Fanconi anemia pathway_Homo sapiens_hsa034602.16553196
10Butanoate metabolism_Homo sapiens_hsa006502.14623319
11Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.13882951
12Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.13497606
13Nitrogen metabolism_Homo sapiens_hsa009102.08725997
14Protein export_Homo sapiens_hsa030602.03164390
15Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.98831462
16Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.90596309
17Homologous recombination_Homo sapiens_hsa034401.73479852
18Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.70872985
19Basal transcription factors_Homo sapiens_hsa030221.70648258
20Ether lipid metabolism_Homo sapiens_hsa005651.67328007
21Non-homologous end-joining_Homo sapiens_hsa034501.62377309
22Morphine addiction_Homo sapiens_hsa050321.59603027
23Taste transduction_Homo sapiens_hsa047421.56813985
24Olfactory transduction_Homo sapiens_hsa047401.54659447
25Propanoate metabolism_Homo sapiens_hsa006401.53900032
26Tryptophan metabolism_Homo sapiens_hsa003801.44643989
27Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.43040447
28RNA polymerase_Homo sapiens_hsa030201.35268974
29Oxidative phosphorylation_Homo sapiens_hsa001901.33302528
30GABAergic synapse_Homo sapiens_hsa047271.28577348
31Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.25849190
32Primary bile acid biosynthesis_Homo sapiens_hsa001201.24573525
33Regulation of autophagy_Homo sapiens_hsa041401.24526199
34RNA degradation_Homo sapiens_hsa030181.22540184
35Circadian entrainment_Homo sapiens_hsa047131.18707526
36Maturity onset diabetes of the young_Homo sapiens_hsa049501.18661854
37Parkinsons disease_Homo sapiens_hsa050121.17928870
38Glutamatergic synapse_Homo sapiens_hsa047241.16487699
39Peroxisome_Homo sapiens_hsa041461.12792029
40Intestinal immune network for IgA production_Homo sapiens_hsa046721.07448864
41ABC transporters_Homo sapiens_hsa020101.07182446
42Steroid hormone biosynthesis_Homo sapiens_hsa001401.05696671
43Selenocompound metabolism_Homo sapiens_hsa004501.05357621
44Insulin secretion_Homo sapiens_hsa049111.03421473
45Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.01045275
46beta-Alanine metabolism_Homo sapiens_hsa004100.99378198
47Serotonergic synapse_Homo sapiens_hsa047260.99073441
48Arachidonic acid metabolism_Homo sapiens_hsa005900.97924650
49Salivary secretion_Homo sapiens_hsa049700.93931630
50Calcium signaling pathway_Homo sapiens_hsa040200.93876315
51One carbon pool by folate_Homo sapiens_hsa006700.92945570
52Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.91058494
53Caffeine metabolism_Homo sapiens_hsa002320.90329121
54Chemical carcinogenesis_Homo sapiens_hsa052040.87826620
55Retinol metabolism_Homo sapiens_hsa008300.87715552
56Cardiac muscle contraction_Homo sapiens_hsa042600.83908295
57Huntingtons disease_Homo sapiens_hsa050160.81852306
58Ovarian steroidogenesis_Homo sapiens_hsa049130.75071679
59Primary immunodeficiency_Homo sapiens_hsa053400.72483610
60Long-term depression_Homo sapiens_hsa047300.72057872
61Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.69288674
62Circadian rhythm_Homo sapiens_hsa047100.68999140
63Glycerolipid metabolism_Homo sapiens_hsa005610.67657618
64Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.67061413
65Dorso-ventral axis formation_Homo sapiens_hsa043200.66390809
66Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.66129862
67Dopaminergic synapse_Homo sapiens_hsa047280.62463284
68Cocaine addiction_Homo sapiens_hsa050300.61443169
69Cysteine and methionine metabolism_Homo sapiens_hsa002700.59803775
70Alzheimers disease_Homo sapiens_hsa050100.58380206
71Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.55679133
72Collecting duct acid secretion_Homo sapiens_hsa049660.54504211
73Cholinergic synapse_Homo sapiens_hsa047250.52506992
74p53 signaling pathway_Homo sapiens_hsa041150.51653468
75Sulfur relay system_Homo sapiens_hsa041220.50782708
76Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.50417516
77Steroid biosynthesis_Homo sapiens_hsa001000.50151761
78RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.49164545
79Purine metabolism_Homo sapiens_hsa002300.47813386
80Metabolic pathways_Homo sapiens_hsa011000.46130733
81Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.45460041
82Asthma_Homo sapiens_hsa053100.44255035
83Lysine degradation_Homo sapiens_hsa003100.43682765
84Amphetamine addiction_Homo sapiens_hsa050310.42233669
85Nucleotide excision repair_Homo sapiens_hsa034200.41881314
86Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.40481079
87Oxytocin signaling pathway_Homo sapiens_hsa049210.40114043
88Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.39442427
89Renin secretion_Homo sapiens_hsa049240.39078224
90Aldosterone synthesis and secretion_Homo sapiens_hsa049250.38957442
91Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.38292208
92SNARE interactions in vesicular transport_Homo sapiens_hsa041300.37362492
93Type I diabetes mellitus_Homo sapiens_hsa049400.36845283
94cAMP signaling pathway_Homo sapiens_hsa040240.35050421
95Fatty acid metabolism_Homo sapiens_hsa012120.34617443
96Glycerophospholipid metabolism_Homo sapiens_hsa005640.33826757
97Vascular smooth muscle contraction_Homo sapiens_hsa042700.32918330
98Hedgehog signaling pathway_Homo sapiens_hsa043400.30200173
99Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.28188924
100Transcriptional misregulation in cancer_Homo sapiens_hsa052020.27031961

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