ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	5.63323267
2	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	4.21205772
3	L-fucose catabolic process (GO:0042355)	4.17261633
4	fucose catabolic process (GO:0019317)	4.17261633
5	L-fucose metabolic process (GO:0042354)	4.17261633
6	response to pheromone (GO:0019236)	3.80497379
7	negative regulation of mast cell activation (GO:0033004)	3.78382022
8	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.73903466
9	neural tube formation (GO:0001841)	3.71655690
10	behavioral response to ethanol (GO:0048149)	3.61100887
11	postsynaptic membrane organization (GO:0001941)	3.38744308
12	positive regulation of oligodendrocyte differentiation (GO:0048714)	3.36688993
13	pyrimidine nucleobase catabolic process (GO:0006208)	3.33478623
14	negative regulation of telomere maintenance (GO:0032205)	3.32810743
15	detection of light stimulus involved in sensory perception (GO:0050962)	3.30476961
16	detection of light stimulus involved in visual perception (GO:0050908)	3.30476961
17	indolalkylamine metabolic process (GO:0006586)	3.27447620
18	protein polyglutamylation (GO:0018095)	3.26569544
19	regulation of action potential (GO:0098900)	3.18418686
20	negative regulation of cytosolic calcium ion concentration (GO:0051481)	3.15668715
21	photoreceptor cell maintenance (GO:0045494)	3.10417123
22	regulation of telomere maintenance (GO:0032204)	3.04835242
23	DNA deamination (GO:0045006)	3.02988110
24	centriole replication (GO:0007099)	3.02812808
25	positive regulation of action potential (GO:0045760)	2.97738186
26	kynurenine metabolic process (GO:0070189)	2.96877755
27	adaptation of signaling pathway (GO:0023058)	2.96808023
28	epithelial cilium movement (GO:0003351)	2.96160597
29	regulation of cilium movement (GO:0003352)	2.94641526
30	cellular ketone body metabolic process (GO:0046950)	2.93985992
31	axoneme assembly (GO:0035082)	2.93655455
32	reflex (GO:0060004)	2.93078914
33	regulation of meiosis I (GO:0060631)	2.91994732
34	synaptic transmission, cholinergic (GO:0007271)	2.91781130
35	ketone body metabolic process (GO:1902224)	2.90888658
36	protein-cofactor linkage (GO:0018065)	2.89918604
37	protein K11-linked deubiquitination (GO:0035871)	2.89913241
38	neuronal action potential (GO:0019228)	2.89440782
39	piRNA metabolic process (GO:0034587)	2.85587240
40	DNA methylation involved in gamete generation (GO:0043046)	2.85530087
41	tryptophan catabolic process (GO:0006569)	2.84995968
42	indole-containing compound catabolic process (GO:0042436)	2.84995968
43	indolalkylamine catabolic process (GO:0046218)	2.84995968
44	cilium morphogenesis (GO:0060271)	2.83873844
45	mannosylation (GO:0097502)	2.83479834
46	ubiquinone metabolic process (GO:0006743)	2.78714627
47	somite development (GO:0061053)	2.76941643
48	cilium or flagellum-dependent cell motility (GO:0001539)	2.75952917
49	tryptophan metabolic process (GO:0006568)	2.75101551
50	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.74576070
51	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.74576070
52	glycosphingolipid biosynthetic process (GO:0006688)	2.71844810
53	nonmotile primary cilium assembly (GO:0035058)	2.71394910
54	platelet dense granule organization (GO:0060155)	2.68438783
55	nucleobase catabolic process (GO:0046113)	2.67923389
56	preassembly of GPI anchor in ER membrane (GO:0016254)	2.63753894
57	presynaptic membrane assembly (GO:0097105)	2.63644635
58	DNA double-strand break processing (GO:0000729)	2.63112775
59	detection of mechanical stimulus involved in sensory perception (GO:0050974)	2.62299685
60	auditory receptor cell stereocilium organization (GO:0060088)	2.61834114
61	C4-dicarboxylate transport (GO:0015740)	2.61207210
62	olfactory bulb development (GO:0021772)	2.61173741
63	reciprocal meiotic recombination (GO:0007131)	2.60931456
64	reciprocal DNA recombination (GO:0035825)	2.60931456
65	negative regulation of reactive oxygen species metabolic process (GO:2000378)	2.56879641
66	cilium organization (GO:0044782)	2.56731469
67	cilium movement (GO:0003341)	2.56457633
68	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.56276159
69	ubiquinone biosynthetic process (GO:0006744)	2.54236037
70	parturition (GO:0007567)	2.53885635
71	establishment of protein localization to Golgi (GO:0072600)	2.53001976
72	recombinational repair (GO:0000725)	2.52584562
73	regulation of collateral sprouting (GO:0048670)	2.52265959
74	tachykinin receptor signaling pathway (GO:0007217)	2.51707367
75	transmission of nerve impulse (GO:0019226)	2.51689261
76	protein complex biogenesis (GO:0070271)	2.51224298
77	gamma-aminobutyric acid transport (GO:0015812)	2.50511773
78	double-strand break repair via homologous recombination (GO:0000724)	2.50391548
79	spinal cord motor neuron differentiation (GO:0021522)	2.50268225
80	startle response (GO:0001964)	2.49311347
81	indole-containing compound metabolic process (GO:0042430)	2.49160140
82	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.48716013
83	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.48716013
84	NADH dehydrogenase complex assembly (GO:0010257)	2.48716013
85	acrosome reaction (GO:0007340)	2.48651227
86	inner ear receptor stereocilium organization (GO:0060122)	2.48452255
87	central nervous system neuron axonogenesis (GO:0021955)	2.47691249
88	positive regulation of mitochondrial fission (GO:0090141)	2.47436191
89	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.46968609
90	regulation of translation, ncRNA-mediated (GO:0045974)	2.46968609
91	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.46968609
92	cilium assembly (GO:0042384)	2.46900626
93	peptidyl-histidine modification (GO:0018202)	2.45820554
94	auditory behavior (GO:0031223)	2.45689184
95	cAMP catabolic process (GO:0006198)	2.45582319
96	cornea development in camera-type eye (GO:0061303)	2.44921351
97	inositol phosphate catabolic process (GO:0071545)	2.44772864
98	presynaptic membrane organization (GO:0097090)	2.44646468
99	dentate gyrus development (GO:0021542)	2.44305252
100	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.43574294

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.80904952
2	EZH2_22144423_ChIP-Seq_EOC_Human	3.41198980
3	VDR_22108803_ChIP-Seq_LS180_Human	3.40698425
4	IGF1R_20145208_ChIP-Seq_DFB_Human	3.12930224
5	GBX2_23144817_ChIP-Seq_PC3_Human	3.09753343
6	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.02760234
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.71149039
8	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.49960059
9	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.33844809
10	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.25255928
11	FUS_26573619_Chip-Seq_HEK293_Human	2.20005397
12	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.13235957
13	EWS_26573619_Chip-Seq_HEK293_Human	2.10509487
14	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.09358712
15	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.08250930
16	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.06481023
17	TAF15_26573619_Chip-Seq_HEK293_Human	2.03725071
18	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.00450396
19	P300_19829295_ChIP-Seq_ESCs_Human	1.99652246
20	ER_23166858_ChIP-Seq_MCF-7_Human	1.95533639
21	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.77115079
22	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.76669121
23	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.74708634
24	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.73748519
25	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.71037767
26	STAT3_23295773_ChIP-Seq_U87_Human	1.69321553
27	CBP_20019798_ChIP-Seq_JUKART_Human	1.67348303
28	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.67348303
29	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.67330429
30	SMAD4_21799915_ChIP-Seq_A2780_Human	1.66796525
31	BCAT_22108803_ChIP-Seq_LS180_Human	1.66221679
32	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.65875625
33	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.65875625
34	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.65790739
35	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.63794492
36	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.59222525
37	TCF4_23295773_ChIP-Seq_U87_Human	1.58258561
38	IRF1_19129219_ChIP-ChIP_H3396_Human	1.57778377
39	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.54382570
40	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.53859755
41	TP53_22573176_ChIP-Seq_HFKS_Human	1.52923187
42	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.51786119
43	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.50212017
44	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.49990790
45	AR_25329375_ChIP-Seq_VCAP_Human	1.48311911
46	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.47514844
47	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.46028821
48	REST_21632747_ChIP-Seq_MESCs_Mouse	1.45038527
49	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.44275627
50	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.41013479
51	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.38031601
52	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.36332475
53	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.35854000
54	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.35008858
55	RUNX2_22187159_ChIP-Seq_PCA_Human	1.34626305
56	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.33996960
57	TCF4_22108803_ChIP-Seq_LS180_Human	1.33524187
58	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.33516228
59	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.31937067
60	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.27020834
61	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.26833582
62	RNF2_27304074_Chip-Seq_NSC_Mouse	1.25238262
63	NANOG_19829295_ChIP-Seq_ESCs_Human	1.24869057
64	SOX2_19829295_ChIP-Seq_ESCs_Human	1.24869057
65	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.22588995
66	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.21805176
67	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.20025218
68	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.18665079
69	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.14724230
70	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.13421243
71	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.13348549
72	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.12739587
73	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.11568032
74	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.11496483
75	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.10505054
76	AR_21572438_ChIP-Seq_LNCaP_Human	1.09832995
77	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.08116789
78	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.07837005
79	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.07345738
80	ELK1_19687146_ChIP-ChIP_HELA_Human	1.06222626
81	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.05946948
82	MYC_18940864_ChIP-ChIP_HL60_Human	1.05764120
83	P53_22387025_ChIP-Seq_ESCs_Mouse	1.05151294
84	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.04654837
85	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.04654837
86	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.02217903
87	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.01960990
88	AR_20517297_ChIP-Seq_VCAP_Human	1.00389233
89	CDX2_22108803_ChIP-Seq_LS180_Human	1.00054168
90	NCOR_22424771_ChIP-Seq_293T_Human	0.98997538
91	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.98273654
92	TP53_16413492_ChIP-PET_HCT116_Human	0.97735936
93	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.97637541
94	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	0.97637224
95	E2F1_18555785_Chip-Seq_ESCs_Mouse	0.97514411
96	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.97358052
97	EST1_17652178_ChIP-ChIP_JURKAT_Human	0.96688623
98	HOXB7_26014856_ChIP-Seq_BT474_Human	0.94226178
99	SOX2_21211035_ChIP-Seq_LN229_Gbm	0.93779970
100	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.93182179

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002102_abnormal_ear_morphology	3.10440941
2	MP0003787_abnormal_imprinting	2.93054925
3	MP0001968_abnormal_touch/_nociception	2.87347279
4	MP0008877_abnormal_DNA_methylation	2.63003834
5	MP0006292_abnormal_olfactory_placode	2.49153712
6	MP0005551_abnormal_eye_electrophysiolog	2.34589752
7	MP0003136_yellow_coat_color	2.33103862
8	MP0001986_abnormal_taste_sensitivity	2.29867532
9	MP0002736_abnormal_nociception_after	2.27014833
10	MP0003880_abnormal_central_pattern	2.22977592
11	MP0003646_muscle_fatigue	2.17263788
12	MP0000569_abnormal_digit_pigmentation	2.06664356
13	MP0000372_irregular_coat_pigmentation	2.06026026
14	MP0004885_abnormal_endolymph	1.94539588
15	MP0002163_abnormal_gland_morphology	1.90214512
16	MP0006276_abnormal_autonomic_nervous	1.84622147
17	MP0001529_abnormal_vocalization	1.84301728
18	MP0005646_abnormal_pituitary_gland	1.84113435
19	MP0009745_abnormal_behavioral_response	1.84107038
20	MP0005253_abnormal_eye_physiology	1.83174268
21	MP0004142_abnormal_muscle_tone	1.79845811
22	MP0004147_increased_porphyrin_level	1.79354973
23	MP0006072_abnormal_retinal_apoptosis	1.79210374
24	MP0003195_calcinosis	1.74380172
25	MP0001501_abnormal_sleep_pattern	1.72916657
26	MP0002272_abnormal_nervous_system	1.68579691
27	MP0000427_abnormal_hair_cycle	1.67835989
28	MP0001486_abnormal_startle_reflex	1.63009331
29	MP0008872_abnormal_physiological_respon	1.60382406
30	MP0002735_abnormal_chemical_nociception	1.57459693
31	MP0009046_muscle_twitch	1.56269404
32	MP0001984_abnormal_olfaction	1.56067222
33	MP0002653_abnormal_ependyma_morphology	1.56057827
34	MP0002876_abnormal_thyroid_physiology	1.55935332
35	MP0002638_abnormal_pupillary_reflex	1.55243288
36	MP0001485_abnormal_pinna_reflex	1.53219860
37	MP0000778_abnormal_nervous_system	1.52629999
38	MP0005645_abnormal_hypothalamus_physiol	1.52307410
39	MP0005174_abnormal_tail_pigmentation	1.50636916
40	MP0002837_dystrophic_cardiac_calcinosis	1.49983507
41	MP0008789_abnormal_olfactory_epithelium	1.48618537
42	MP0004742_abnormal_vestibular_system	1.48459036
43	MP0004133_heterotaxia	1.44677824
44	MP0002095_abnormal_skin_pigmentation	1.40700817
45	MP0000015_abnormal_ear_pigmentation	1.39457089
46	MP0000631_abnormal_neuroendocrine_gland	1.39020262
47	MP0002572_abnormal_emotion/affect_behav	1.35978510
48	MP0005171_absent_coat_pigmentation	1.34104816
49	MP0004043_abnormal_pH_regulation	1.32236271
50	MP0005379_endocrine/exocrine_gland_phen	1.31836822
51	MP0005386_behavior/neurological_phenoty	1.28968231
52	MP0004924_abnormal_behavior	1.28968231
53	MP0002234_abnormal_pharynx_morphology	1.27295769
54	MP0002557_abnormal_social/conspecific_i	1.26630255
55	MP0008057_abnormal_DNA_replication	1.24608220
56	MP0003635_abnormal_synaptic_transmissio	1.23143618
57	MP0001970_abnormal_pain_threshold	1.20261202
58	MP0002067_abnormal_sensory_capabilities	1.19548455
59	MP0005187_abnormal_penis_morphology	1.18831285
60	MP0008995_early_reproductive_senescence	1.17347681
61	MP0003121_genomic_imprinting	1.14862401
62	MP0002733_abnormal_thermal_nociception	1.12644508
63	MP0000647_abnormal_sebaceous_gland	1.08668220
64	MP0002064_seizures	1.07229170
65	MP0005377_hearing/vestibular/ear_phenot	1.06748133
66	MP0003878_abnormal_ear_physiology	1.06748133
67	MP0002063_abnormal_learning/memory/cond	1.06593402
68	MP0002160_abnormal_reproductive_system	1.06053089
69	MP0008775_abnormal_heart_ventricle	1.04197956
70	MP0002928_abnormal_bile_duct	1.04132445
71	MP0005499_abnormal_olfactory_system	1.01190957
72	MP0005394_taste/olfaction_phenotype	1.01190957
73	MP0001324_abnormal_eye_pigmentation	1.00876110
74	MP0005195_abnormal_posterior_eye	0.99714703
75	MP0002734_abnormal_mechanical_nocicepti	0.97326371
76	MP0005389_reproductive_system_phenotype	0.96875716
77	MP0002752_abnormal_somatic_nervous	0.95923442
78	MP0008058_abnormal_DNA_repair	0.94303553
79	MP0000230_abnormal_systemic_arterial	0.92784319
80	MP0002184_abnormal_innervation	0.91999803
81	MP0005075_abnormal_melanosome_morpholog	0.91688312
82	MP0000383_abnormal_hair_follicle	0.91648086
83	MP0002938_white_spotting	0.90181576
84	MP0003718_maternal_effect	0.89163724
85	MP0000026_abnormal_inner_ear	0.89048003
86	MP0005167_abnormal_blood-brain_barrier	0.88721868
87	MP0001905_abnormal_dopamine_level	0.88520679
88	MP0009697_abnormal_copulation	0.87876693
89	MP0001963_abnormal_hearing_physiology	0.87174553
90	MP0002751_abnormal_autonomic_nervous	0.86539739
91	MP0005084_abnormal_gallbladder_morpholo	0.85234304
92	MP0003011_delayed_dark_adaptation	0.85153273
93	MP0003698_abnormal_male_reproductive	0.82595258
94	MP0003122_maternal_imprinting	0.82365898
95	MP0005391_vision/eye_phenotype	0.82228646
96	MP0001502_abnormal_circadian_rhythm	0.81776125
97	MP0002229_neurodegeneration	0.80869944
98	MP0002882_abnormal_neuron_morphology	0.79798333
99	MP0001929_abnormal_gametogenesis	0.78796590
100	MP0010386_abnormal_urinary_bladder	0.77876312

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.48013286
2	Pancreatic fibrosis (HP:0100732)	4.10350870
3	Abnormality of midbrain morphology (HP:0002418)	3.87747216
4	Molar tooth sign on MRI (HP:0002419)	3.87747216
5	Nephronophthisis (HP:0000090)	3.84583007
6	True hermaphroditism (HP:0010459)	3.69961438
7	Chronic hepatic failure (HP:0100626)	3.43542725
8	Abnormality of the renal cortex (HP:0011035)	3.40343987
9	Abnormality of the renal medulla (HP:0100957)	3.36044335
10	Hyperventilation (HP:0002883)	3.32969763
11	Type II lissencephaly (HP:0007260)	3.31973849
12	Congenital stationary night blindness (HP:0007642)	3.21271465
13	Medial flaring of the eyebrow (HP:0010747)	3.07249080
14	Attenuation of retinal blood vessels (HP:0007843)	3.06616836
15	Neoplasm of the adrenal cortex (HP:0100641)	2.98448423
16	Abolished electroretinogram (ERG) (HP:0000550)	2.98389848
17	Keratoconus (HP:0000563)	2.83065681
18	Increased corneal curvature (HP:0100692)	2.83065681
19	Tubular atrophy (HP:0000092)	2.74208794
20	Cystic liver disease (HP:0006706)	2.65215105
21	3-Methylglutaconic aciduria (HP:0003535)	2.63071403
22	Polydipsia (HP:0001959)	2.61733146
23	Abnormal drinking behavior (HP:0030082)	2.61733146
24	Gaze-evoked nystagmus (HP:0000640)	2.49725830
25	Intestinal atresia (HP:0011100)	2.45970314
26	Stomach cancer (HP:0012126)	2.44482063
27	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.42696575
28	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.42339134
29	Renal cortical cysts (HP:0000803)	2.38140567
30	Lissencephaly (HP:0001339)	2.36396417
31	Abnormal rod and cone electroretinograms (HP:0008323)	2.36221607
32	Bony spicule pigmentary retinopathy (HP:0007737)	2.35570772
33	Congenital hepatic fibrosis (HP:0002612)	2.34686141
34	Focal motor seizures (HP:0011153)	2.33650025
35	Retinal dysplasia (HP:0007973)	2.33538207
36	Absent speech (HP:0001344)	2.32686742
37	Sclerocornea (HP:0000647)	2.31803513
38	Metaphyseal dysplasia (HP:0100255)	2.31658411
39	Anencephaly (HP:0002323)	2.30665466
40	Pendular nystagmus (HP:0012043)	2.26388217
41	Cerebellar dysplasia (HP:0007033)	2.24720468
42	Gait imbalance (HP:0002141)	2.22871647
43	Focal seizures (HP:0007359)	2.20533674
44	Inability to walk (HP:0002540)	2.20099571
45	Polyuria (HP:0000103)	2.16439611
46	Decreased central vision (HP:0007663)	2.16168901
47	Congenital primary aphakia (HP:0007707)	2.15349882
48	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.12744267
49	Bile duct proliferation (HP:0001408)	2.12211985
50	Abnormal biliary tract physiology (HP:0012439)	2.12211985
51	Progressive cerebellar ataxia (HP:0002073)	2.11347596
52	Febrile seizures (HP:0002373)	2.10724966
53	Abnormality of the labia minora (HP:0012880)	2.09920670
54	Postaxial foot polydactyly (HP:0001830)	2.09719882
55	Oligodactyly (hands) (HP:0001180)	2.09051127
56	Optic nerve hypoplasia (HP:0000609)	2.08688236
57	Nephrogenic diabetes insipidus (HP:0009806)	2.06756657
58	Chorioretinal atrophy (HP:0000533)	2.05056240
59	Thyroiditis (HP:0100646)	2.03786064
60	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.00639704
61	Abnormality of alanine metabolism (HP:0010916)	2.00639704
62	Hyperalaninemia (HP:0003348)	2.00639704
63	Broad-based gait (HP:0002136)	1.97816137
64	Tubulointerstitial abnormality (HP:0001969)	1.97286910
65	Colon cancer (HP:0003003)	1.94824170
66	Abnormality of DNA repair (HP:0003254)	1.94639699
67	Pachygyria (HP:0001302)	1.92954494
68	Genital tract atresia (HP:0001827)	1.91506386
69	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.88192124
70	Optic disc pallor (HP:0000543)	1.87417974
71	Tubulointerstitial nephritis (HP:0001970)	1.84341288
72	Patellar aplasia (HP:0006443)	1.84224168
73	Occipital encephalocele (HP:0002085)	1.83697279
74	Dandy-Walker malformation (HP:0001305)	1.83600812
75	Type 2 muscle fiber atrophy (HP:0003554)	1.83198305
76	Hemiparesis (HP:0001269)	1.82463709
77	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.82209389
78	Growth hormone deficiency (HP:0000824)	1.82068635
79	Progressive inability to walk (HP:0002505)	1.81665496
80	Postaxial hand polydactyly (HP:0001162)	1.80559016
81	Aplasia/Hypoplasia of the patella (HP:0006498)	1.80051009
82	Protruding tongue (HP:0010808)	1.79570720
83	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.78027108
84	Anterior segment dysgenesis (HP:0007700)	1.76020829
85	Concave nail (HP:0001598)	1.75445809
86	Hypothermia (HP:0002045)	1.75336961
87	Hypoplasia of the pons (HP:0012110)	1.74343949
88	Genetic anticipation (HP:0003743)	1.73996712
89	Decreased circulating renin level (HP:0003351)	1.73283157
90	Ectopic kidney (HP:0000086)	1.72402413
91	Preaxial hand polydactyly (HP:0001177)	1.72018401
92	Dialeptic seizures (HP:0011146)	1.71805054
93	Narrow forehead (HP:0000341)	1.71397002
94	Vaginal atresia (HP:0000148)	1.71131711
95	Increased CSF lactate (HP:0002490)	1.71004303
96	Large for gestational age (HP:0001520)	1.70997385
97	Male pseudohermaphroditism (HP:0000037)	1.70600115
98	Tubulointerstitial fibrosis (HP:0005576)	1.70219922
99	Abnormal respiratory epithelium morphology (HP:0012253)	1.68495953
100	Abnormal respiratory motile cilium morphology (HP:0005938)	1.68495953

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.86732969
2	MAP4K2	2.81066833
3	ADRBK2	2.69432574
4	BMPR1B	2.60898884
5	PINK1	2.58217893
6	NUAK1	2.50409902
7	CASK	2.26807883
8	WNK3	2.13191910
9	MARK1	2.12359403
10	INSRR	2.08668432
11	ZAK	2.08070145
12	MAPK13	2.07613277
13	TAOK3	2.02267115
14	CAMKK2	1.92012082
15	ACVR1B	1.77216983
16	WNK4	1.66567480
17	PNCK	1.61728657
18	STK39	1.55650972
19	OXSR1	1.47541518
20	MAP3K4	1.45760882
21	PAK3	1.41712280
22	PLK2	1.41195406
23	GRK1	1.41053259
24	DAPK2	1.38447057
25	TRIM28	1.26250567
26	BCR	1.24197394
27	MKNK2	1.23896084
28	EIF2AK3	1.17959771
29	TXK	1.14702767
30	AKT3	1.13898456
31	ADRBK1	1.11504578
32	MAP2K7	1.10075056
33	PTK2B	1.08357953
34	CAMK1G	1.02010097
35	EPHA4	1.01722912
36	DYRK2	1.00626989
37	CAMK1D	1.00116503
38	TNIK	0.95330217
39	PIK3CA	0.91447198
40	TLK1	0.91360051
41	CSNK1G2	0.88675301
42	PRKCE	0.85979840
43	TEC	0.85215657
44	PLK4	0.84066275
45	CAMK1	0.79118875
46	CDK19	0.79038928
47	ERBB3	0.78787392
48	NTRK3	0.78415059
49	TIE1	0.77578677
50	CSNK1A1L	0.76958216
51	SIK2	0.76760774
52	CSNK1G1	0.74518221
53	PRKCG	0.73725028
54	CAMK4	0.73400879
55	CSNK1G3	0.73350851
56	STK38L	0.70877444
57	CDK8	0.68447458
58	STK11	0.67134488
59	IKBKB	0.61689048
60	MAP3K7	0.61186187
61	NTRK2	0.59934613
62	SGK2	0.58808621
63	MUSK	0.57979448
64	CAMK2A	0.55613643
65	PRKCQ	0.53080308
66	TGFBR1	0.51924248
67	VRK1	0.51910681
68	ATR	0.51854320
69	PKN1	0.51455180
70	FER	0.50439154
71	BCKDK	0.49757142
72	MAP2K6	0.49462361
73	MKNK1	0.48902031
74	DYRK3	0.48819095
75	BRSK2	0.48009275
76	PRKCZ	0.46219105
77	CAMKK1	0.46049092
78	PLK3	0.45812799
79	CSNK1D	0.45137038
80	FLT3	0.43465024
81	TNK2	0.42637020
82	PRKAA2	0.41547810
83	ITK	0.41348859
84	PRKACA	0.40102227
85	CSNK1A1	0.39917497
86	PHKG2	0.39293758
87	PHKG1	0.39293758
88	ATM	0.38445388
89	DYRK1A	0.37813041
90	MAP2K4	0.37219570
91	SGK494	0.36608510
92	SGK223	0.36608510
93	MAPKAPK5	0.35707026
94	GRK5	0.34846569
95	MARK3	0.33995600
96	BRD4	0.33425252
97	IRAK1	0.33243867
98	ABL1	0.33205050
99	CCNB1	0.33087898
100	PRKAA1	0.32840021

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	3.09742212
2	Phototransduction_Homo sapiens_hsa04744	2.98017275
3	Nicotine addiction_Homo sapiens_hsa05033	2.67237223
4	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.60105860
5	Linoleic acid metabolism_Homo sapiens_hsa00591	2.51873532
6	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.50116625
7	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.39268218
8	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.33828974
9	Fanconi anemia pathway_Homo sapiens_hsa03460	2.16553196
10	Butanoate metabolism_Homo sapiens_hsa00650	2.14623319
11	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.13882951
12	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.13497606
13	Nitrogen metabolism_Homo sapiens_hsa00910	2.08725997
14	Protein export_Homo sapiens_hsa03060	2.03164390
15	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.98831462
16	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.90596309
17	Homologous recombination_Homo sapiens_hsa03440	1.73479852
18	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.70872985
19	Basal transcription factors_Homo sapiens_hsa03022	1.70648258
20	Ether lipid metabolism_Homo sapiens_hsa00565	1.67328007
21	Non-homologous end-joining_Homo sapiens_hsa03450	1.62377309
22	Morphine addiction_Homo sapiens_hsa05032	1.59603027
23	Taste transduction_Homo sapiens_hsa04742	1.56813985
24	Olfactory transduction_Homo sapiens_hsa04740	1.54659447
25	Propanoate metabolism_Homo sapiens_hsa00640	1.53900032
26	Tryptophan metabolism_Homo sapiens_hsa00380	1.44643989
27	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.43040447
28	RNA polymerase_Homo sapiens_hsa03020	1.35268974
29	Oxidative phosphorylation_Homo sapiens_hsa00190	1.33302528
30	GABAergic synapse_Homo sapiens_hsa04727	1.28577348
31	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.25849190
32	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.24573525
33	Regulation of autophagy_Homo sapiens_hsa04140	1.24526199
34	RNA degradation_Homo sapiens_hsa03018	1.22540184
35	Circadian entrainment_Homo sapiens_hsa04713	1.18707526
36	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.18661854
37	Parkinsons disease_Homo sapiens_hsa05012	1.17928870
38	Glutamatergic synapse_Homo sapiens_hsa04724	1.16487699
39	Peroxisome_Homo sapiens_hsa04146	1.12792029
40	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.07448864
41	ABC transporters_Homo sapiens_hsa02010	1.07182446
42	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.05696671
43	Selenocompound metabolism_Homo sapiens_hsa00450	1.05357621
44	Insulin secretion_Homo sapiens_hsa04911	1.03421473
45	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.01045275
46	beta-Alanine metabolism_Homo sapiens_hsa00410	0.99378198
47	Serotonergic synapse_Homo sapiens_hsa04726	0.99073441
48	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.97924650
49	Salivary secretion_Homo sapiens_hsa04970	0.93931630
50	Calcium signaling pathway_Homo sapiens_hsa04020	0.93876315
51	One carbon pool by folate_Homo sapiens_hsa00670	0.92945570
52	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.91058494
53	Caffeine metabolism_Homo sapiens_hsa00232	0.90329121
54	Chemical carcinogenesis_Homo sapiens_hsa05204	0.87826620
55	Retinol metabolism_Homo sapiens_hsa00830	0.87715552
56	Cardiac muscle contraction_Homo sapiens_hsa04260	0.83908295
57	Huntingtons disease_Homo sapiens_hsa05016	0.81852306
58	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.75071679
59	Primary immunodeficiency_Homo sapiens_hsa05340	0.72483610
60	Long-term depression_Homo sapiens_hsa04730	0.72057872
61	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.69288674
62	Circadian rhythm_Homo sapiens_hsa04710	0.68999140
63	Glycerolipid metabolism_Homo sapiens_hsa00561	0.67657618
64	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.67061413
65	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.66390809
66	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.66129862
67	Dopaminergic synapse_Homo sapiens_hsa04728	0.62463284
68	Cocaine addiction_Homo sapiens_hsa05030	0.61443169
69	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.59803775
70	Alzheimers disease_Homo sapiens_hsa05010	0.58380206
71	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.55679133
72	Collecting duct acid secretion_Homo sapiens_hsa04966	0.54504211
73	Cholinergic synapse_Homo sapiens_hsa04725	0.52506992
74	p53 signaling pathway_Homo sapiens_hsa04115	0.51653468
75	Sulfur relay system_Homo sapiens_hsa04122	0.50782708
76	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.50417516
77	Steroid biosynthesis_Homo sapiens_hsa00100	0.50151761
78	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.49164545
79	Purine metabolism_Homo sapiens_hsa00230	0.47813386
80	Metabolic pathways_Homo sapiens_hsa01100	0.46130733
81	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.45460041
82	Asthma_Homo sapiens_hsa05310	0.44255035
83	Lysine degradation_Homo sapiens_hsa00310	0.43682765
84	Amphetamine addiction_Homo sapiens_hsa05031	0.42233669
85	Nucleotide excision repair_Homo sapiens_hsa03420	0.41881314
86	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.40481079
87	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.40114043
88	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.39442427
89	Renin secretion_Homo sapiens_hsa04924	0.39078224
90	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.38957442
91	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.38292208
92	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.37362492
93	Type I diabetes mellitus_Homo sapiens_hsa04940	0.36845283
94	cAMP signaling pathway_Homo sapiens_hsa04024	0.35050421
95	Fatty acid metabolism_Homo sapiens_hsa01212	0.34617443
96	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.33826757
97	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.32918330
98	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.30200173
99	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.28188924
100	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.27031961

FAM106A

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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