FAM107A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)6.46422908
2central nervous system myelination (GO:0022010)6.46422908
3locomotory exploration behavior (GO:0035641)6.10371358
4L-amino acid import (GO:0043092)6.03429859
5synaptic vesicle maturation (GO:0016188)5.94611576
6cellular potassium ion homeostasis (GO:0030007)5.74365919
7sodium ion export (GO:0071436)5.54053130
8C4-dicarboxylate transport (GO:0015740)5.51701644
9postsynaptic membrane organization (GO:0001941)5.19518805
10positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.11049079
11regulation of short-term neuronal synaptic plasticity (GO:0048172)5.07617860
12synaptic vesicle exocytosis (GO:0016079)4.96854451
13amino acid import (GO:0043090)4.94987441
14glutamate secretion (GO:0014047)4.87463425
15vocalization behavior (GO:0071625)4.81862151
16regulation of synapse maturation (GO:0090128)4.77352803
17gamma-aminobutyric acid transport (GO:0015812)4.70138827
18regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.64504421
19neuronal action potential propagation (GO:0019227)4.61639593
20phosphorelay signal transduction system (GO:0000160)4.50432202
21positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.50274947
22synaptic vesicle docking involved in exocytosis (GO:0016081)4.42679370
23potassium ion import (GO:0010107)4.41854835
24membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.38665563
25neurotransmitter secretion (GO:0007269)4.35050546
26regulation of glutamate receptor signaling pathway (GO:1900449)4.32712033
27ionotropic glutamate receptor signaling pathway (GO:0035235)4.27091717
28regulation of synaptic vesicle exocytosis (GO:2000300)4.26190774
29cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.23611849
30layer formation in cerebral cortex (GO:0021819)4.17923258
31positive regulation of synaptic transmission, glutamatergic (GO:0051968)4.14282487
32cell communication by electrical coupling (GO:0010644)4.10920992
33positive regulation of potassium ion transmembrane transporter activity (GO:1901018)4.10694304
34positive regulation of dendritic spine morphogenesis (GO:0061003)4.09657813
35cerebellar granule cell differentiation (GO:0021707)4.08469927
36regulation of long-term neuronal synaptic plasticity (GO:0048169)4.05151229
37positive regulation of dendritic spine development (GO:0060999)4.02113785
38exploration behavior (GO:0035640)4.01137652
39cellular sodium ion homeostasis (GO:0006883)3.95767494
40regulation of neuronal synaptic plasticity (GO:0048168)3.94196866
41long-term memory (GO:0007616)3.94034696
42regulation of synapse structural plasticity (GO:0051823)3.93876427
43neurotransmitter-gated ion channel clustering (GO:0072578)3.92515987
44glutamate receptor signaling pathway (GO:0007215)3.92161599
45presynaptic membrane assembly (GO:0097105)3.91159534
46synaptic transmission, glutamatergic (GO:0035249)3.89297091
47potassium ion homeostasis (GO:0055075)3.84561228
48regulation of synaptic vesicle transport (GO:1902803)3.81951930
49response to auditory stimulus (GO:0010996)3.81936629
50presynaptic membrane organization (GO:0097090)3.80463026
51acidic amino acid transport (GO:0015800)3.72727241
52negative regulation of glycogen biosynthetic process (GO:0045719)3.70614094
53neurotransmitter transport (GO:0006836)3.61009865
54L-glutamate transport (GO:0015813)3.58271995
55long-term synaptic potentiation (GO:0060291)3.55087501
56protein localization to synapse (GO:0035418)3.52160883
57dendritic spine morphogenesis (GO:0060997)3.52043464
58neuron-neuron synaptic transmission (GO:0007270)3.50446171
59regulation of neurotransmitter uptake (GO:0051580)3.48374609
60regulation of neurotransmitter levels (GO:0001505)3.47127598
61G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.46451240
62auditory behavior (GO:0031223)3.46291076
63neurotransmitter uptake (GO:0001504)3.45829228
64cerebellar Purkinje cell differentiation (GO:0021702)3.45366471
65membrane repolarization (GO:0086009)3.41622930
66regulation of synaptic transmission, glutamatergic (GO:0051966)3.36190464
67neuromuscular process controlling balance (GO:0050885)3.35281575
68transmission of nerve impulse (GO:0019226)3.33941591
69regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.32528385
70adenine nucleotide transport (GO:0051503)3.31905308
71regulation of excitatory postsynaptic membrane potential (GO:0060079)3.31815504
72positive regulation of membrane potential (GO:0045838)3.31424417
73ovulation cycle (GO:0042698)3.31047245
74regulation of synaptic plasticity (GO:0048167)3.30229866
75regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.28995302
76membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.26977443
77positive regulation of potassium ion transmembrane transport (GO:1901381)3.25485252
78negative regulation of synaptic transmission, GABAergic (GO:0032229)3.25369170
79regulation of ARF protein signal transduction (GO:0032012)3.25271009
80serotonin metabolic process (GO:0042428)3.24077680
81neuron cell-cell adhesion (GO:0007158)3.19555357
82regulation of membrane repolarization (GO:0060306)3.18446885
83dendrite morphogenesis (GO:0048813)3.18069412
84gamma-aminobutyric acid signaling pathway (GO:0007214)3.16920041
85proline transport (GO:0015824)3.16434237
86regulation of dendritic spine development (GO:0060998)3.15649337
87neuromuscular synaptic transmission (GO:0007274)3.08997069
88multicellular organismal signaling (GO:0035637)3.08149603
89regulation of postsynaptic membrane potential (GO:0060078)3.06976918
90neuromuscular process controlling posture (GO:0050884)3.03235409
91regulation of vesicle fusion (GO:0031338)3.02791895
92regulation of neurotransmitter secretion (GO:0046928)3.02642492
93prepulse inhibition (GO:0060134)3.02346310
94negative regulation of glycogen metabolic process (GO:0070874)3.01824468
95regulation of voltage-gated calcium channel activity (GO:1901385)3.00788456
96regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.00124614
97negative regulation of cytosolic calcium ion concentration (GO:0051481)2.98734990
98glycine transport (GO:0015816)2.98681202
99negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.97126941
100synaptic vesicle endocytosis (GO:0048488)2.95197570
101negative regulation of astrocyte differentiation (GO:0048712)2.94919624
102regulation of dendritic spine morphogenesis (GO:0061001)2.94385002
103positive regulation of synapse maturation (GO:0090129)2.94208192
104membrane hyperpolarization (GO:0060081)2.93638075
105positive regulation of cardiac muscle cell differentiation (GO:2000727)2.93547809
106regulation of female receptivity (GO:0045924)2.93168285
107regulation of neurotransmitter transport (GO:0051588)2.92453499
108positive regulation of synaptic transmission (GO:0050806)2.92361703
109cell differentiation in hindbrain (GO:0021533)2.91602312
110primary amino compound metabolic process (GO:1901160)2.91532752
111positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.90560017
112regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.87520219
113membrane repolarization during action potential (GO:0086011)2.86986379
114activation of protein kinase A activity (GO:0034199)2.83479819
115positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.83411421
116adult walking behavior (GO:0007628)2.82251553
117alanine transport (GO:0032328)2.81622014
118purine nucleotide transport (GO:0015865)2.81282152
119membrane depolarization during action potential (GO:0086010)2.81279625
120mechanosensory behavior (GO:0007638)2.80555111
121positive regulation of potassium ion transport (GO:0043268)2.79663888
122long term synaptic depression (GO:0060292)2.79158152
123positive regulation of sodium ion transport (GO:0010765)2.78791012
124regulation of synaptic transmission (GO:0050804)2.76152181
125neuronal ion channel clustering (GO:0045161)2.74532922
126membrane depolarization (GO:0051899)2.71405494

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.42293555
2SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.15422489
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.04156109
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.95094577
5EZH2_18974828_ChIP-Seq_MESCs_Mouse2.79215745
6RNF2_18974828_ChIP-Seq_MESCs_Mouse2.79215745
7DROSHA_22980978_ChIP-Seq_HELA_Human2.73709340
8JARID2_20075857_ChIP-Seq_MESCs_Mouse2.61209798
9MTF2_20144788_ChIP-Seq_MESCs_Mouse2.57555393
10SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.57482087
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.55071651
12RARB_27405468_Chip-Seq_BRAIN_Mouse2.54002592
13GBX2_23144817_ChIP-Seq_PC3_Human2.50572783
14SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.50479241
15SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.47961449
16IKZF1_21737484_ChIP-ChIP_HCT116_Human2.46519893
17REST_21632747_ChIP-Seq_MESCs_Mouse2.44018694
18EZH2_27304074_Chip-Seq_ESCs_Mouse2.30773324
19EED_16625203_ChIP-ChIP_MESCs_Mouse2.30764407
20* RNF2_27304074_Chip-Seq_ESCs_Mouse2.24879271
21* EZH2_27294783_Chip-Seq_ESCs_Mouse2.18891197
22* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.18008426
23MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.16855916
24FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.00355216
25ERG_21242973_ChIP-ChIP_JURKAT_Human1.99389369
26REST_18959480_ChIP-ChIP_MESCs_Mouse1.94391753
27AR_21572438_ChIP-Seq_LNCaP_Human1.85028980
28EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.83769518
29HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.68119715
30GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.59080374
31GATA1_26923725_Chip-Seq_HPCs_Mouse1.58777870
32RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.57362532
33SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.44820623
34SMAD_19615063_ChIP-ChIP_OVARY_Human1.44130985
35BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.43108672
36RING1B_27294783_Chip-Seq_ESCs_Mouse1.40288138
37SMAD4_21799915_ChIP-Seq_A2780_Human1.40002975
38TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.35303459
39PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.33806340
40RXR_22108803_ChIP-Seq_LS180_Human1.32569374
41AR_19668381_ChIP-Seq_PC3_Human1.27415310
42CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27021071
43CTBP2_25329375_ChIP-Seq_LNCAP_Human1.26900617
44WT1_25993318_ChIP-Seq_PODOCYTE_Human1.26575399
45ZNF217_24962896_ChIP-Seq_MCF-7_Human1.23353030
46WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.23192273
47RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.22935862
48DNAJC2_21179169_ChIP-ChIP_NT2_Human1.22549108
49* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.20987756
50GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20257484
51KDM2B_26808549_Chip-Seq_K562_Human1.20173628
52NR3C1_23031785_ChIP-Seq_PC12_Mouse1.20124199
53ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.19952330
54CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.19808194
55NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.19225152
56THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.18464056
57RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.17975799
58AR_25329375_ChIP-Seq_VCAP_Human1.16860448
59RING1B_27294783_Chip-Seq_NPCs_Mouse1.16156217
60SOX2_21211035_ChIP-Seq_LN229_Gbm1.14918726
61PIAS1_25552417_ChIP-Seq_VCAP_Human1.13380423
62SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.11388470
63ZFP281_18757296_ChIP-ChIP_E14_Mouse1.10036297
64CTBP1_25329375_ChIP-Seq_LNCAP_Human1.09593847
65NR3C1_21868756_ChIP-Seq_MCF10A_Human1.09368057
66BMI1_23680149_ChIP-Seq_NPCS_Mouse1.07843355
67P300_19829295_ChIP-Seq_ESCs_Human1.07527502
68ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.07364399
69SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06695791
70CDX2_19796622_ChIP-Seq_MESCs_Mouse1.06494751
71EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.06209630
72ZFP281_27345836_Chip-Seq_ESCs_Mouse1.06156470
73RNF2_27304074_Chip-Seq_NSC_Mouse1.05894153
74TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.05861968
75CBX2_27304074_Chip-Seq_ESCs_Mouse1.04694604
76SMAD3_21741376_ChIP-Seq_EPCs_Human1.04352245
77STAT3_23295773_ChIP-Seq_U87_Human1.03659964
78EP300_21415370_ChIP-Seq_HL-1_Mouse1.00592019
79MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.99230140
80TP53_16413492_ChIP-PET_HCT116_Human0.99056858
81TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.98739869
82SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98161242
83BCAT_22108803_ChIP-Seq_LS180_Human0.97114337
84SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.96835855
85PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.96719037
86YAP1_20516196_ChIP-Seq_MESCs_Mouse0.96574008
87ARNT_22903824_ChIP-Seq_MCF-7_Human0.95836902
88SMAD4_21741376_ChIP-Seq_HESCs_Human0.94931587
89GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94739490
90BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.93479577
91OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.93179188
92ESR2_21235772_ChIP-Seq_MCF-7_Human0.93025625
93TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.91983126
94STAT6_21828071_ChIP-Seq_BEAS2B_Human0.91976922
95SMAD3_21741376_ChIP-Seq_HESCs_Human0.91103789
96ESR1_20079471_ChIP-ChIP_T-47D_Human0.91006611
97TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90909505
98* TCF4_23295773_ChIP-Seq_U87_Human0.90650421
99AHR_22903824_ChIP-Seq_MCF-7_Human0.88842859
100MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.88559706
101* SMAD3_21741376_ChIP-Seq_ESCs_Human0.88452386
102ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.88410853
103OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.88240947
104RUNX1_26923725_Chip-Seq_HPCs_Mouse0.88079566
105CTCF_27219007_Chip-Seq_Bcells_Human0.87476424
106* TP53_23651856_ChIP-Seq_MEFs_Mouse0.87468930
107ZFP57_27257070_Chip-Seq_ESCs_Mouse0.87418786
108TP53_20018659_ChIP-ChIP_R1E_Mouse0.87234613
109TET1_21490601_ChIP-Seq_MESCs_Mouse0.86794175
110LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86619612
111AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.86565215
112P53_22127205_ChIP-Seq_FIBROBLAST_Human0.85650024
113POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.85292551
114TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85292551
115TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.85063381
116TOP2B_26459242_ChIP-Seq_MCF-7_Human0.83045476
117EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.81565015
118PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.80975617
119TP53_18474530_ChIP-ChIP_U2OS_Human0.80711192
120CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.80018602
121OCT4_19829295_ChIP-Seq_ESCs_Human0.77322038
122KLF4_19829295_ChIP-Seq_ESCs_Human0.77281265

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.52205611
2MP0003635_abnormal_synaptic_transmissio3.99813530
3MP0009046_muscle_twitch3.49688438
4MP0003880_abnormal_central_pattern3.30777121
5MP0009745_abnormal_behavioral_response3.28598622
6MP0004270_analgesia3.27488546
7MP0002064_seizures3.22789139
8MP0002063_abnormal_learning/memory/cond3.15876934
9MP0001486_abnormal_startle_reflex2.94436599
10MP0002837_dystrophic_cardiac_calcinosis2.92668305
11MP0004885_abnormal_endolymph2.92269382
12MP0008569_lethality_at_weaning2.90060677
13MP0002572_abnormal_emotion/affect_behav2.70403205
14MP0005423_abnormal_somatic_nervous2.68395526
15MP0002272_abnormal_nervous_system2.66317761
16MP0001968_abnormal_touch/_nociception2.59545752
17MP0004858_abnormal_nervous_system2.53404335
18MP0002734_abnormal_mechanical_nocicepti2.40227415
19MP0001501_abnormal_sleep_pattern2.37203868
20MP0002822_catalepsy2.35189040
21MP0009780_abnormal_chondrocyte_physiolo2.28941865
22MP0003690_abnormal_glial_cell2.12915991
23MP0002067_abnormal_sensory_capabilities2.07372793
24MP0005646_abnormal_pituitary_gland2.01802564
25MP0001440_abnormal_grooming_behavior1.97694397
26MP0002736_abnormal_nociception_after1.97653952
27MP0003329_amyloid_beta_deposits1.81178258
28MP0003633_abnormal_nervous_system1.80290889
29MP0002557_abnormal_social/conspecific_i1.77739729
30MP0002733_abnormal_thermal_nociception1.74857458
31MP0002909_abnormal_adrenal_gland1.72564156
32MP0001485_abnormal_pinna_reflex1.70777983
33MP0001348_abnormal_lacrimal_gland1.70712249
34MP0001970_abnormal_pain_threshold1.68502695
35MP0000778_abnormal_nervous_system1.64074137
36MP0003879_abnormal_hair_cell1.60998044
37MP0001502_abnormal_circadian_rhythm1.59772762
38MP0002735_abnormal_chemical_nociception1.54904624
39MP0000955_abnormal_spinal_cord1.50383282
40MP0004811_abnormal_neuron_physiology1.48310926
41MP0005386_behavior/neurological_phenoty1.47958337
42MP0004924_abnormal_behavior1.47958337
43MP0003631_nervous_system_phenotype1.44639467
44MP0002184_abnormal_innervation1.41655949
45MP0002066_abnormal_motor_capabilities/c1.39059842
46MP0004043_abnormal_pH_regulation1.38198587
47MP0002882_abnormal_neuron_morphology1.36557187
48MP0002638_abnormal_pupillary_reflex1.34975228
49MP0003075_altered_response_to1.27964062
50MP0005377_hearing/vestibular/ear_phenot1.27785948
51MP0003878_abnormal_ear_physiology1.27785948
52MP0006292_abnormal_olfactory_placode1.26551508
53MP0004142_abnormal_muscle_tone1.24966841
54MP0001984_abnormal_olfaction1.24236777
55MP0000920_abnormal_myelination1.20322648
56MP0003634_abnormal_glial_cell1.19442546
57MP0002152_abnormal_brain_morphology1.15742411
58MP0000537_abnormal_urethra_morphology1.15066922
59MP0005167_abnormal_blood-brain_barrier1.13877292
60MP0002090_abnormal_vision1.11100215
61MP0008872_abnormal_physiological_respon1.10345066
62MP0001963_abnormal_hearing_physiology1.09933075
63MP0003632_abnormal_nervous_system1.07518345
64MP0004742_abnormal_vestibular_system1.05713159
65MP0005645_abnormal_hypothalamus_physiol1.04206886
66MP0002229_neurodegeneration0.99169461
67MP0004215_abnormal_myocardial_fiber0.98979989
68MP0003646_muscle_fatigue0.98136340
69MP0004145_abnormal_muscle_electrophysio0.97393348
70MP0008874_decreased_physiological_sensi0.95724677
71MP0005551_abnormal_eye_electrophysiolog0.95183289
72MP0004185_abnormal_adipocyte_glucose0.94636245
73MP0001905_abnormal_dopamine_level0.93945480
74MP0002160_abnormal_reproductive_system0.89592167
75MP0001177_atelectasis0.89476704
76MP0003011_delayed_dark_adaptation0.86049893
77MP0002069_abnormal_eating/drinking_beha0.85980833
78MP0005535_abnormal_body_temperature0.84349117
79MP0003938_abnormal_ear_development0.83605027
80MP0003122_maternal_imprinting0.81878432
81MP0003137_abnormal_impulse_conducting0.80957495
82MP0008961_abnormal_basal_metabolism0.80795040
83MP0005379_endocrine/exocrine_gland_phen0.80594927
84MP0004130_abnormal_muscle_cell0.80050672
85MP0004085_abnormal_heartbeat0.79912252
86MP0003183_abnormal_peptide_metabolism0.79469915
87MP0001299_abnormal_eye_distance/0.76155860
88MP0000604_amyloidosis0.75942601
89MP0005499_abnormal_olfactory_system0.73431053
90MP0005394_taste/olfaction_phenotype0.73431053
91MP0000026_abnormal_inner_ear0.73150774
92MP0002249_abnormal_larynx_morphology0.72486471
93MP0005623_abnormal_meninges_morphology0.71096688
94MP0003787_abnormal_imprinting0.71023976
95MP0002089_abnormal_postnatal_growth/wei0.69572293
96MP0002752_abnormal_somatic_nervous0.65934061
97MP0000013_abnormal_adipose_tissue0.65625645
98MP0004484_altered_response_of0.65391535
99MP0000631_abnormal_neuroendocrine_gland0.64913956
100MP0001986_abnormal_taste_sensitivity0.64567254
101MP0003283_abnormal_digestive_organ0.64370768
102MP0003567_abnormal_fetal_cardiomyocyte0.64076147
103MP0000566_synostosis0.63959946
104MP0004233_abnormal_muscle_weight0.63167709
105MP0000751_myopathy0.63053460
106MP0005253_abnormal_eye_physiology0.62519699
107MP0005595_abnormal_vascular_smooth0.61774505
108MP0006072_abnormal_retinal_apoptosis0.60675417
109MP0009053_abnormal_anal_canal0.59666103
110MP0000049_abnormal_middle_ear0.58981129
111MP0005332_abnormal_amino_acid0.58326137
112MP0005248_abnormal_Harderian_gland0.56910085
113MP0004147_increased_porphyrin_level0.56788578
114MP0010769_abnormal_survival0.56142607
115MP0003119_abnormal_digestive_system0.55836605
116MP0002653_abnormal_ependyma_morphology0.55746259
117MP0003123_paternal_imprinting0.55399475
118MP0000747_muscle_weakness0.55332155
119MP0006276_abnormal_autonomic_nervous0.55216128
120MP0004019_abnormal_vitamin_homeostasis0.54917617
121MP0003172_abnormal_lysosome_physiology0.54364454
122MP0005389_reproductive_system_phenotype0.51233946
123MP0003861_abnormal_nervous_system0.50704175
124MP0005195_abnormal_posterior_eye0.50050499

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.16579037
2Myokymia (HP:0002411)6.48285064
3Action tremor (HP:0002345)5.45488915
4Focal seizures (HP:0007359)5.07756918
5Progressive cerebellar ataxia (HP:0002073)4.89585907
6Visual hallucinations (HP:0002367)4.69071942
7Megalencephaly (HP:0001355)4.53272671
8Epileptic encephalopathy (HP:0200134)4.51940169
9Dysdiadochokinesis (HP:0002075)4.22948020
10Absence seizures (HP:0002121)3.90483804
11Generalized tonic-clonic seizures (HP:0002069)3.87592518
12Abnormality of the middle phalanges of the toes (HP:0010183)3.80437824
13Hemiplegia (HP:0002301)3.78061116
14Atonic seizures (HP:0010819)3.69005406
15Febrile seizures (HP:0002373)3.67641716
16Abnormal eating behavior (HP:0100738)3.64510226
17Gaze-evoked nystagmus (HP:0000640)3.63213499
18Diplopia (HP:0000651)3.62232820
19Abnormality of binocular vision (HP:0011514)3.62232820
20Intention tremor (HP:0002080)3.48837850
21Dialeptic seizures (HP:0011146)3.43082618
22Genetic anticipation (HP:0003743)3.42921397
23Aplasia involving bones of the extremities (HP:0009825)3.41181969
24Aplasia involving bones of the upper limbs (HP:0009823)3.41181969
25Aplasia of the phalanges of the hand (HP:0009802)3.41181969
26Hemiparesis (HP:0001269)3.37780315
27Abnormality of the proximal phalanges of the hand (HP:0009834)3.31733663
28Postural instability (HP:0002172)3.31548790
29Status epilepticus (HP:0002133)3.27444469
30Dysmetria (HP:0001310)3.22118626
31Anxiety (HP:0000739)3.20761191
32Broad-based gait (HP:0002136)3.16134225
33Depression (HP:0000716)3.15304338
34Poor eye contact (HP:0000817)3.09066333
35Annular pancreas (HP:0001734)3.00879537
36Dysmetric saccades (HP:0000641)3.00765780
37Scanning speech (HP:0002168)2.96805027
38Impaired social interactions (HP:0000735)2.89585157
39Abnormal social behavior (HP:0012433)2.89585157
40Truncal ataxia (HP:0002078)2.86851114
41Impaired smooth pursuit (HP:0007772)2.86290231
42Increased circulating renin level (HP:0000848)2.82996811
43Supranuclear gaze palsy (HP:0000605)2.82811650
44Impaired vibration sensation in the lower limbs (HP:0002166)2.74311804
45Papilledema (HP:0001085)2.74270161
46Hyperventilation (HP:0002883)2.70950703
47Abnormality of ocular smooth pursuit (HP:0000617)2.64462989
48Obstructive sleep apnea (HP:0002870)2.62335761
49Clumsiness (HP:0002312)2.58727092
50Ankle clonus (HP:0011448)2.53322409
51Urinary bladder sphincter dysfunction (HP:0002839)2.51268230
52Stereotypic behavior (HP:0000733)2.49570409
53Abnormality of the neuromuscular junction (HP:0003398)2.49161247
54Fatigable weakness (HP:0003473)2.49161247
55Synostosis of carpal bones (HP:0005048)2.48097354
56Limb dystonia (HP:0002451)2.46449007
57Metabolic alkalosis (HP:0200114)2.44502814
58Ventricular fibrillation (HP:0001663)2.41365393
59Tetraplegia (HP:0002445)2.36619119
60Severe global developmental delay (HP:0011344)2.35618869
61Abnormality of the periventricular white matter (HP:0002518)2.34833940
62Short hallux (HP:0010109)2.34538982
63Anomalous pulmonary venous return (HP:0010772)2.32861241
64Neurofibrillary tangles (HP:0002185)2.32784350
65Symphalangism affecting the phalanges of the hand (HP:0009773)2.30086883
66Centrally nucleated skeletal muscle fibers (HP:0003687)2.29507622
67Postural tremor (HP:0002174)2.27111050
68Bradykinesia (HP:0002067)2.26983488
69Lower limb asymmetry (HP:0100559)2.25370896
70Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.24739559
71Synostosis involving the elbow (HP:0003938)2.23859903
72Humeroradial synostosis (HP:0003041)2.23859903
73Aplasia/Hypoplasia of the hallux (HP:0008362)2.20781762
74Cerebral hypomyelination (HP:0006808)2.18800719
75Akinesia (HP:0002304)2.17938523
76Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.17579267
77Sleep apnea (HP:0010535)2.17512853
78Mildly elevated creatine phosphokinase (HP:0008180)2.17325414
79Abnormality of the phalanges of the 2nd finger (HP:0009541)2.16254034
80Pheochromocytoma (HP:0002666)2.15369723
81Spinal canal stenosis (HP:0003416)2.15099015
82Abnormality of saccadic eye movements (HP:0000570)2.13370049
83Syncope (HP:0001279)2.12928919
84Bundle branch block (HP:0011710)2.12275882
85Hypoplasia of the uterus (HP:0000013)2.12094401
86Torticollis (HP:0000473)2.11400161
87Abnormality of the lower motor neuron (HP:0002366)2.10306827
88Urinary urgency (HP:0000012)2.10229776
89Impaired vibratory sensation (HP:0002495)2.09690583
90Fibular aplasia (HP:0002990)2.09650412
91Abnormality of the corticospinal tract (HP:0002492)2.09594062
92Abnormality of the phalanges of the 5th finger (HP:0004213)2.08273418
93Focal dystonia (HP:0004373)2.07499343
94Polyphagia (HP:0002591)2.04856140
95Abnormality of the pulmonary veins (HP:0011718)1.99871783
96Psychosis (HP:0000709)1.97513038
97Gait ataxia (HP:0002066)1.96753070
98Abnormality of the nasal septum (HP:0000419)1.96658430
99Morphological abnormality of the inner ear (HP:0011390)1.96142420
100Spastic gait (HP:0002064)1.95861820
101Confusion (HP:0001289)1.94637307
102Peripheral hypomyelination (HP:0007182)1.94389127
103Drooling (HP:0002307)1.93880280
104Excessive salivation (HP:0003781)1.93880280
105Bradycardia (HP:0001662)1.92680367
106Pointed chin (HP:0000307)1.91053181
107Mutism (HP:0002300)1.90376315
108Myotonia (HP:0002486)1.89890487
109Abnormal EKG (HP:0003115)1.88511098
110Delusions (HP:0000746)1.88281390
111Congenital stationary night blindness (HP:0007642)1.87867550
112Limb ataxia (HP:0002070)1.87355476
113Hypokalemic alkalosis (HP:0001949)1.87352979
114Cerebral inclusion bodies (HP:0100314)1.86796298
115Incomplete penetrance (HP:0003829)1.86463269
116Segmental peripheral demyelination/remyelination (HP:0003481)1.86213626
117Osteomalacia (HP:0002749)1.85827376
118Generalized myoclonic seizures (HP:0002123)1.84940396
119Split foot (HP:0001839)1.84320060
120Spastic tetraparesis (HP:0001285)1.83716658
121Lower limb muscle weakness (HP:0007340)1.82301466
122Slow progression (HP:0003677)1.81871968
123Conjunctival hamartoma (HP:0100780)1.80617377
124Bronchomalacia (HP:0002780)1.80112933
125Rigidity (HP:0002063)1.79867001
126Neuroendocrine neoplasm (HP:0100634)1.79590636
127Amblyopia (HP:0000646)1.79216364
128Hamartoma of the eye (HP:0010568)1.79070318
129Insomnia (HP:0100785)1.79011365
130Onion bulb formation (HP:0003383)1.78995545
131Neuronal loss in central nervous system (HP:0002529)1.77983274
132Heart block (HP:0012722)1.77503073
1332-3 toe syndactyly (HP:0004691)1.77218216
134Neoplasm of the peripheral nervous system (HP:0100007)1.74778680
135Athetosis (HP:0002305)1.71987418
136Fetal akinesia sequence (HP:0001989)1.68541563
137Epileptiform EEG discharges (HP:0011182)1.68366132
138Craniofacial dystonia (HP:0012179)1.67114877
139Thin ribs (HP:0000883)1.66480266
140EEG with generalized epileptiform discharges (HP:0011198)1.66111274

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.01533998
2NTRK33.57781096
3NTRK23.19915135
4TRIB33.01710992
5MAP3K92.87962939
6PRKD32.75675517
7CAMKK12.38954572
8MAP3K42.32247405
9SGK22.27721160
10DAPK22.26321250
11MINK12.25961447
12SGK2232.05108908
13SGK4942.05108908
14PAK62.03563925
15MAP2K71.99471722
16SGK31.98731155
17NTRK11.87293451
18TNIK1.79318721
19MUSK1.72325668
20CAMKK21.63911049
21KSR21.62870342
22MARK11.62429595
23LMTK21.61710089
24STK381.61642419
25PRPF4B1.60845607
26CDK51.50313943
27PINK11.49942904
28MAP2K41.49552846
29RIPK41.40849492
30CDK191.37022304
31RIPK11.35910122
32TYRO31.32967626
33PHKG11.28074362
34PHKG21.28074362
35MAPKAPK31.20968781
36PLK21.14214603
37PRKCG1.13590588
38DMPK1.12967766
39OXSR11.12663990
40CAMK11.10253877
41KSR11.07742299
42PKN11.07192579
43PRKCH1.05397565
44CAMK1G1.04994682
45MAP3K131.03975525
46CASK1.00199725
47FES0.97593375
48MAP3K20.96811480
49LIMK10.96319120
50WNK10.93937052
51DAPK10.93572105
52STK110.92153538
53PDPK10.90056138
54PDK10.87666901
55SGK10.87331741
56SIK20.87099595
57CDK140.86362752
58GRK50.86059633
59CDK150.85449893
60CDK180.84120215
61UHMK10.83574718
62RET0.83166417
63MAPK130.82852405
64NEK60.82041474
65MAP3K120.79450841
66ERBB20.76650344
67CAMK2A0.73785099
68TAOK10.73098734
69CDK11A0.72792397
70CAMK40.68791219
71PNCK0.67890229
72CSNK1G20.66803061
73GRK10.66688065
74ALK0.64829859
75MAP3K70.63044482
76ROCK10.61651974
77ARAF0.61175923
78DDR20.60043059
79FGFR20.58897793
80CAMK2B0.58353119
81DYRK1A0.58237217
82PAK30.56728105
83RPS6KA30.56692542
84LATS20.54820511
85CAMK2G0.54258895
86PRKAA10.53968325
87WNK30.50524379
88PRKACA0.49662052
89RPS6KA20.49547244
90CDC42BPA0.49192780
91TNK20.48224985
92FRK0.48210392
93MARK20.48034724
94PTK2B0.47741239
95PRKCE0.45271922
96CAMK1D0.45130648
97IRAK20.44738366
98FYN0.43587036
99ROCK20.42815452
100ABL20.41802069
101MAP3K10.41389700
102BMPR20.41090969
103MAPK80.39674476
104PRKCQ0.39494180
105CAMK2D0.38288376
106MAPK120.38171120
107MAPK100.38156983
108PRKCZ0.36634133
109MAP3K110.36254660
110GSK3B0.36219118
111SRC0.36054296
112RPS6KB10.35769370
113PRKCB0.35366543
114BMX0.35278768
115MAPK90.35231502
116PRKCA0.34909388
117PRKACG0.34886436
118PKN20.34871124
119CSNK1A10.33828227
120PRKG10.33639045
121MAPK40.33431566
122PRKD10.33367920

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009107.52095580
2Nicotine addiction_Homo sapiens_hsa050332.86239731
3Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.57828093
4Glutamatergic synapse_Homo sapiens_hsa047242.46514642
5Synaptic vesicle cycle_Homo sapiens_hsa047212.43665407
6GABAergic synapse_Homo sapiens_hsa047272.42186006
7Circadian entrainment_Homo sapiens_hsa047132.16167048
8Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.14864265
9Long-term potentiation_Homo sapiens_hsa047202.09340421
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.07362208
11Morphine addiction_Homo sapiens_hsa050322.02220761
12Olfactory transduction_Homo sapiens_hsa047401.98277243
13Salivary secretion_Homo sapiens_hsa049701.92289722
14Gastric acid secretion_Homo sapiens_hsa049711.90955937
15Amphetamine addiction_Homo sapiens_hsa050311.77601033
16Insulin secretion_Homo sapiens_hsa049111.71744746
17Dopaminergic synapse_Homo sapiens_hsa047281.55871515
18Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.54731248
19Cholinergic synapse_Homo sapiens_hsa047251.53141944
20Histidine metabolism_Homo sapiens_hsa003401.49744878
21Long-term depression_Homo sapiens_hsa047301.47261187
22Aldosterone synthesis and secretion_Homo sapiens_hsa049251.43732606
23Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.41154740
24Taste transduction_Homo sapiens_hsa047421.30361899
25Fatty acid biosynthesis_Homo sapiens_hsa000611.25729609
26Oxytocin signaling pathway_Homo sapiens_hsa049211.20016203
27Cocaine addiction_Homo sapiens_hsa050301.19661076
28Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.17818386
29Calcium signaling pathway_Homo sapiens_hsa040201.17683749
30Phototransduction_Homo sapiens_hsa047441.16330285
31Renin secretion_Homo sapiens_hsa049241.15615713
32cAMP signaling pathway_Homo sapiens_hsa040241.14199482
33Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.11828889
34Dorso-ventral axis formation_Homo sapiens_hsa043201.11192622
35Vitamin B6 metabolism_Homo sapiens_hsa007501.10256505
36Arginine biosynthesis_Homo sapiens_hsa002201.09796835
37Serotonergic synapse_Homo sapiens_hsa047261.01572190
38Carbohydrate digestion and absorption_Homo sapiens_hsa049731.01438873
39Circadian rhythm_Homo sapiens_hsa047100.98612072
40GnRH signaling pathway_Homo sapiens_hsa049120.98250136
41Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.97945134
42Phospholipase D signaling pathway_Homo sapiens_hsa040720.96793191
43Estrogen signaling pathway_Homo sapiens_hsa049150.95785604
44Pancreatic secretion_Homo sapiens_hsa049720.94810503
45Bile secretion_Homo sapiens_hsa049760.92687674
46Gap junction_Homo sapiens_hsa045400.92482803
47Glioma_Homo sapiens_hsa052140.91404592
48Phosphatidylinositol signaling system_Homo sapiens_hsa040700.91010886
49Type II diabetes mellitus_Homo sapiens_hsa049300.90352323
50Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.90282483
51Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.86979960
52Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.86306324
53cGMP-PKG signaling pathway_Homo sapiens_hsa040220.83842664
54Thyroid hormone synthesis_Homo sapiens_hsa049180.83834828
55Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.79635071
56Melanogenesis_Homo sapiens_hsa049160.76915638
57Cardiac muscle contraction_Homo sapiens_hsa042600.76030273
58ErbB signaling pathway_Homo sapiens_hsa040120.73175776
59Thyroid hormone signaling pathway_Homo sapiens_hsa049190.72619065
60Arginine and proline metabolism_Homo sapiens_hsa003300.71747874
61Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.69893670
62Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.69051842
63Choline metabolism in cancer_Homo sapiens_hsa052310.66126013
64Collecting duct acid secretion_Homo sapiens_hsa049660.65681022
65Vascular smooth muscle contraction_Homo sapiens_hsa042700.60055861
66Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.59967280
67Neurotrophin signaling pathway_Homo sapiens_hsa047220.57330905
68Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.56275820
69MAPK signaling pathway_Homo sapiens_hsa040100.55069169
70Butanoate metabolism_Homo sapiens_hsa006500.53401197
71Axon guidance_Homo sapiens_hsa043600.53258655
72Rap1 signaling pathway_Homo sapiens_hsa040150.53066702
73Dilated cardiomyopathy_Homo sapiens_hsa054140.52657177
74Glycerolipid metabolism_Homo sapiens_hsa005610.52005473
75Glucagon signaling pathway_Homo sapiens_hsa049220.50967807
76Mineral absorption_Homo sapiens_hsa049780.48795020
77Sphingolipid signaling pathway_Homo sapiens_hsa040710.47520660
78beta-Alanine metabolism_Homo sapiens_hsa004100.47440689
79VEGF signaling pathway_Homo sapiens_hsa043700.46239754
80Longevity regulating pathway - mammal_Homo sapiens_hsa042110.44202867
81Prion diseases_Homo sapiens_hsa050200.43997101
82Ras signaling pathway_Homo sapiens_hsa040140.43433991
83Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.43380482
84Renal cell carcinoma_Homo sapiens_hsa052110.40809409
85Endocytosis_Homo sapiens_hsa041440.40386909
86Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.40349776
87Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.39089807
88Oocyte meiosis_Homo sapiens_hsa041140.38984626
89mTOR signaling pathway_Homo sapiens_hsa041500.38621917
90Inositol phosphate metabolism_Homo sapiens_hsa005620.38338794
91Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.37676408
92Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.37582300
93Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.37437305
94Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.37083104
95Non-small cell lung cancer_Homo sapiens_hsa052230.36488871
96Endometrial cancer_Homo sapiens_hsa052130.36273523
97Adipocytokine signaling pathway_Homo sapiens_hsa049200.34998887
98Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.34364933
99Hippo signaling pathway_Homo sapiens_hsa043900.33851634
100Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.33161023
101Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.32748953
102Fatty acid metabolism_Homo sapiens_hsa012120.32142874
103Chemokine signaling pathway_Homo sapiens_hsa040620.26991383
104Alzheimers disease_Homo sapiens_hsa050100.26761299
105African trypanosomiasis_Homo sapiens_hsa051430.26079539
106Insulin signaling pathway_Homo sapiens_hsa049100.24789263
107Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.24144472
108Pentose and glucuronate interconversions_Homo sapiens_hsa000400.24078817
109Wnt signaling pathway_Homo sapiens_hsa043100.23612123
110Type I diabetes mellitus_Homo sapiens_hsa049400.23355671
111AMPK signaling pathway_Homo sapiens_hsa041520.23243959
112Alcoholism_Homo sapiens_hsa050340.21984232
113Sulfur metabolism_Homo sapiens_hsa009200.21688998
114Melanoma_Homo sapiens_hsa052180.21503315
115Insulin resistance_Homo sapiens_hsa049310.20962644
116PPAR signaling pathway_Homo sapiens_hsa033200.20307614
117Glycerophospholipid metabolism_Homo sapiens_hsa005640.20143633
118Hedgehog signaling pathway_Homo sapiens_hsa043400.19765578
119Cyanoamino acid metabolism_Homo sapiens_hsa004600.19513041

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