FAM109A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that localizes to the endosome and interacts with the enzyme, inositol polyphosphate 5-phosphatase OCRL-1. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)5.01057253
2glycosphingolipid catabolic process (GO:0046479)4.99528003
3intestinal absorption (GO:0050892)4.81254342
4oligosaccharide catabolic process (GO:0009313)4.66245498
5glycolipid catabolic process (GO:0019377)4.64775962
6purine nucleobase biosynthetic process (GO:0009113)4.52348919
7fat-soluble vitamin biosynthetic process (GO:0042362)4.32249102
8response to pheromone (GO:0019236)4.25824429
9atrioventricular valve morphogenesis (GO:0003181)4.10824350
10G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071994.01357951
11ceramide catabolic process (GO:0046514)3.98910002
12pyrimidine nucleobase catabolic process (GO:0006208)3.93830603
13virion attachment to host cell (GO:0019062)3.87604707
14adhesion of symbiont to host cell (GO:0044650)3.87604707
15cell-cell junction maintenance (GO:0045217)3.82051450
16paraxial mesoderm development (GO:0048339)3.80291202
17intestinal cholesterol absorption (GO:0030299)3.78546662
18adhesion of symbiont to host (GO:0044406)3.74847152
19nucleobase biosynthetic process (GO:0046112)3.71003254
20mitotic metaphase plate congression (GO:0007080)3.65997944
21very-low-density lipoprotein particle assembly (GO:0034379)3.65743033
22nucleobase catabolic process (GO:0046113)3.63404348
23barbed-end actin filament capping (GO:0051016)3.61566364
24plasma lipoprotein particle assembly (GO:0034377)3.59054291
25lung-associated mesenchyme development (GO:0060484)3.57191582
26sphingolipid catabolic process (GO:0030149)3.56968605
27peptide catabolic process (GO:0043171)3.52893758
28epithelial cell differentiation involved in prostate gland development (GO:0060742)3.52749823
29membrane lipid catabolic process (GO:0046466)3.50990226
30epithelial cell fate commitment (GO:0072148)3.49171441
31vitamin A metabolic process (GO:0006776)3.48240960
32ventricular cardiac muscle cell action potential (GO:0086005)3.48026857
33regulation of cholesterol esterification (GO:0010872)3.44382741
34intracellular estrogen receptor signaling pathway (GO:0030520)3.43971287
35chondrocyte proliferation (GO:0035988)3.43092652
36fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.40228108
37negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)3.38173312
38pattern specification involved in kidney development (GO:0061004)3.37230826
39bundle of His cell to Purkinje myocyte communication (GO:0086069)3.37004963
40regulation of chromatin binding (GO:0035561)3.36831931
41protein-lipid complex assembly (GO:0065005)3.36599186
42regulation of cholesterol homeostasis (GO:2000188)3.34799390
43positive regulation of lipoprotein lipase activity (GO:0051006)3.31730214
44positive regulation of triglyceride lipase activity (GO:0061365)3.31730214
45DNA deamination (GO:0045006)3.28787787
46phospholipid efflux (GO:0033700)3.26595396
47folic acid metabolic process (GO:0046655)3.23915271
48epoxygenase P450 pathway (GO:0019373)3.20207720
49cell junction maintenance (GO:0034331)3.15878018
50lung epithelium development (GO:0060428)3.15843546
51endocardial cushion morphogenesis (GO:0003203)3.13775838
52regulation of extracellular matrix disassembly (GO:0010715)3.13725731
53intestinal epithelial cell development (GO:0060576)3.12470553
54respiratory tube development (GO:0030323)3.11634657
55glucose 6-phosphate metabolic process (GO:0051156)3.10702863
56epithelial cell-cell adhesion (GO:0090136)3.09196158
57cell migration involved in heart development (GO:0060973)3.07665633
58NADH metabolic process (GO:0006734)3.06047487
59diacylglycerol metabolic process (GO:0046339)3.04899120
60epithelial structure maintenance (GO:0010669)3.04214882
61lens fiber cell development (GO:0070307)3.02585054
62lipoprotein transport (GO:0042953)3.01749653
63peptidyl-arginine omega-N-methylation (GO:0035247)3.01377147
64regulation of cardioblast differentiation (GO:0051890)2.98192253
65fructose metabolic process (GO:0006000)2.97318921
66spliceosomal snRNP assembly (GO:0000387)2.97176825
67regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)2.96609587
68endocrine process (GO:0050886)2.96609587
69regulation of systemic arterial blood pressure by hormone (GO:0001990)2.96609587
70segment specification (GO:0007379)2.96416135
71positive regulation of fatty acid biosynthetic process (GO:0045723)2.96399509
72maintenance of gastrointestinal epithelium (GO:0030277)2.94317126
73low-density lipoprotein particle remodeling (GO:0034374)2.94168154
74triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.93357521
75regulation of cell-cell adhesion mediated by cadherin (GO:2000047)2.93012836
76urea cycle (GO:0000050)2.92334227
77modified amino acid transport (GO:0072337)2.91582167
78regulation of guanylate cyclase activity (GO:0031282)2.91471752
79protein retention in ER lumen (GO:0006621)2.91185420
80negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.87472397
81urea metabolic process (GO:0019627)2.87051854
82embryonic foregut morphogenesis (GO:0048617)2.85101366
83regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)2.84923712
84hormone catabolic process (GO:0042447)2.83789128
85regulation of early endosome to late endosome transport (GO:2000641)2.82291626
86plasma lipoprotein particle remodeling (GO:0034369)2.81289281
87protein-lipid complex remodeling (GO:0034368)2.81289281
88macromolecular complex remodeling (GO:0034367)2.81289281
89negative regulation of keratinocyte proliferation (GO:0010839)2.80641185
90negative regulation of DNA-templated transcription, elongation (GO:0032785)2.79412001
91negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.79412001
92cholesterol efflux (GO:0033344)2.79392327
93regulation of G0 to G1 transition (GO:0070316)2.79305189
94mesenchyme morphogenesis (GO:0072132)2.79021740
95cell migration in hindbrain (GO:0021535)2.78497049
96low-density lipoprotein particle clearance (GO:0034383)2.78396286
97ventricular cardiac muscle cell development (GO:0055015)2.76160540
98amino sugar catabolic process (GO:0046348)2.75666002
99regulation of somitogenesis (GO:0014807)2.73749964
100plasma lipoprotein particle organization (GO:0071827)2.73453121
101midgut development (GO:0007494)2.72829782
102cellular response to nutrient (GO:0031670)2.72705896
103negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.71950737
104epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.70550295
105angiotensin maturation (GO:0002003)2.69759881
106regulation of cholesterol storage (GO:0010885)2.69222764
107apoptotic cell clearance (GO:0043277)2.68830127
108regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.68094777
109regulation of bile acid biosynthetic process (GO:0070857)2.67302630
110regulation of systemic arterial blood pressure (GO:0003073)2.66509090
111cellular response to cadmium ion (GO:0071276)2.66435848
112protein-lipid complex subunit organization (GO:0071825)2.66392831
113regulation of hippo signaling (GO:0035330)2.65620543
114mannose metabolic process (GO:0006013)2.65487516
115lipoprotein metabolic process (GO:0042157)2.64952059
116renal system process involved in regulation of blood volume (GO:0001977)2.64873785
117alpha-linolenic acid metabolic process (GO:0036109)2.64681831
118amyloid precursor protein catabolic process (GO:0042987)2.64625499
119basement membrane organization (GO:0071711)2.61694680
120negative regulation of fibrinolysis (GO:0051918)2.61560498
121pinocytosis (GO:0006907)2.61423936
122heart valve formation (GO:0003188)2.61239376
123DNA replication checkpoint (GO:0000076)2.60933282
124cellular response to pH (GO:0071467)2.59743314
125maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.59737249
126histone arginine methylation (GO:0034969)2.58660011
127ectoderm development (GO:0007398)2.58582220
128protein localization to endosome (GO:0036010)2.57836195
129plasma lipoprotein particle clearance (GO:0034381)2.57744708
130sphingomyelin metabolic process (GO:0006684)2.57442829
131mitotic spindle assembly checkpoint (GO:0007094)2.56940577
132trophectodermal cell differentiation (GO:0001829)2.55391657
133vitamin transmembrane transport (GO:0035461)2.55328064
134apoptotic process involved in morphogenesis (GO:0060561)2.55176511
135positive regulation of extracellular matrix organization (GO:1903055)2.55096589
136positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.54377702
137regulation of apoptotic cell clearance (GO:2000425)2.53203864
138regulation of mononuclear cell migration (GO:0071675)2.52548623
139renal absorption (GO:0070293)2.52208494
140nitrogen cycle metabolic process (GO:0071941)2.52132466
141peptide hormone processing (GO:0016486)2.51836803
142ribosome assembly (GO:0042255)2.50341421
143regulation of extracellular matrix organization (GO:1903053)2.49211516
144UDP-N-acetylglucosamine metabolic process (GO:0006047)2.49162573
145DNA damage response, signal transduction resulting in transcription (GO:0042772)2.47995040
146neuron projection extension involved in neuron projection guidance (GO:1902284)2.47726426
147axon extension involved in axon guidance (GO:0048846)2.47726426
148peptidyl-glutamic acid carboxylation (GO:0017187)2.46679355
149protein carboxylation (GO:0018214)2.46679355
150notochord development (GO:0030903)2.45829495
151embryonic camera-type eye development (GO:0031076)2.45542007
152proline biosynthetic process (GO:0006561)2.45141688
153actin filament depolymerization (GO:0030042)2.44579146
154negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.43610487
155negative regulation of sister chromatid segregation (GO:0033046)2.43610487
156negative regulation of mitotic sister chromatid separation (GO:2000816)2.43610487
157negative regulation of mitotic sister chromatid segregation (GO:0033048)2.43610487
158renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)2.43403796
159proline metabolic process (GO:0006560)2.43084575
160cellular response to thyroid hormone stimulus (GO:0097067)2.43015674
161high-density lipoprotein particle remodeling (GO:0034375)2.42477964
162negative regulation of translational initiation (GO:0045947)2.42114806
163histone H2A monoubiquitination (GO:0035518)2.41594655
164negative regulation of RNA splicing (GO:0033119)2.41460405
165negative regulation of chromosome segregation (GO:0051985)2.41405193
166spindle assembly checkpoint (GO:0071173)2.40827387
167negative regulation of cell size (GO:0045792)2.39811472
168glycoside metabolic process (GO:0016137)2.39078476
169stress fiber assembly (GO:0043149)2.38998688
170glial cell migration (GO:0008347)2.38485574
171maturation of SSU-rRNA (GO:0030490)2.38157056
172neuronal stem cell maintenance (GO:0097150)2.37661347
173collecting duct development (GO:0072044)2.36659167
174mitotic spindle checkpoint (GO:0071174)2.36221009
175peptidyl-arginine methylation (GO:0018216)2.35957316
176peptidyl-arginine N-methylation (GO:0035246)2.35957316
177protein insertion into membrane (GO:0051205)2.35227922
178dorsal/ventral neural tube patterning (GO:0021904)2.35122257
179negative regulation of oligodendrocyte differentiation (GO:0048715)2.35086743
180response to acidic pH (GO:0010447)2.34655472
181regulation of vitamin metabolic process (GO:0030656)2.33846997
182glycine metabolic process (GO:0006544)2.33387868
183positive regulation of Cdc42 GTPase activity (GO:0043089)2.32581118
184negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.32147375
185activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.32094981
186digestive system process (GO:0022600)2.31905778
187gastrulation with mouth forming second (GO:0001702)2.31494684
188ventricular septum morphogenesis (GO:0060412)2.30814661
189regulation of cholesterol metabolic process (GO:0090181)2.30655893
190apoptotic process involved in development (GO:1902742)2.30516329
191planar cell polarity pathway involved in neural tube closure (GO:0090179)2.30472671
192mitochondrial RNA metabolic process (GO:0000959)2.30213320
193positive regulation of receptor recycling (GO:0001921)2.29566493
194oligosaccharide metabolic process (GO:0009311)2.28808501
195regulation of superoxide anion generation (GO:0032928)2.28532863
196positive regulation of systemic arterial blood pressure (GO:0003084)2.28058331
197receptor catabolic process (GO:0032801)2.27277510

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.75868171
2TP63_17297297_ChIP-ChIP_HaCaT_Human3.62427861
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.01603934
4THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.97064084
5FOXM1_23109430_ChIP-Seq_U2OS_Human2.88432004
6ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.86353019
7MYC_18555785_ChIP-Seq_MESCs_Mouse2.77313505
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.69054768
9NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.64332655
10TP63_19390658_ChIP-ChIP_HaCaT_Human2.60610352
11ZNF263_19887448_ChIP-Seq_K562_Human2.38051537
12RXR_22158963_ChIP-Seq_LIVER_Mouse2.23446845
13* XRN2_22483619_ChIP-Seq_HELA_Human2.17031011
14MYC_19079543_ChIP-ChIP_MESCs_Mouse2.15416731
15VDR_21846776_ChIP-Seq_THP-1_Human2.10848386
16E2F7_22180533_ChIP-Seq_HELA_Human2.10779038
17FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.07268869
18ESR2_21235772_ChIP-Seq_MCF-7_Human2.06364162
19KDM2B_26808549_Chip-Seq_SUP-B15_Human2.05494666
20MYC_18358816_ChIP-ChIP_MESCs_Mouse2.01894687
21SRY_22984422_ChIP-ChIP_TESTIS_Rat1.96765895
22CREB1_15753290_ChIP-ChIP_HEK293T_Human1.90794118
23ETS1_20019798_ChIP-Seq_JURKAT_Human1.88671634
24NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.83393563
25JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.82768604
26CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.80089835
27NELFA_20434984_ChIP-Seq_ESCs_Mouse1.78412186
28MYC_19030024_ChIP-ChIP_MESCs_Mouse1.78071666
29MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.78047674
30PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.74173754
31NANOG_18555785_ChIP-Seq_MESCs_Mouse1.73987174
32TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.70287228
33STAT6_21828071_ChIP-Seq_BEAS2B_Human1.69626550
34ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.69335030
35KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.69170632
36YY1_21170310_ChIP-Seq_MESCs_Mouse1.68977291
37ERG_21242973_ChIP-ChIP_JURKAT_Human1.64983662
38KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.63635851
39* KDM2B_26808549_Chip-Seq_K562_Human1.62155375
40POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.61566560
41TRIM28_21343339_ChIP-Seq_HEK293_Human1.60775632
42AR_21909140_ChIP-Seq_LNCAP_Human1.57808139
43SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.57083051
44MYC_22102868_ChIP-Seq_BL_Human1.56689549
45TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.55249284
46DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.52726007
47KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.52298921
48VDR_24763502_ChIP-Seq_THP-1_Human1.50811866
49* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.50363944
50CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.50259305
51LXR_22158963_ChIP-Seq_LIVER_Mouse1.48799481
52KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.48017030
53KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.47527173
54KDM2B_26808549_Chip-Seq_DND41_Human1.47348948
55RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.46974644
56TET1_21451524_ChIP-Seq_MESCs_Mouse1.46409630
57CIITA_25753668_ChIP-Seq_RAJI_Human1.45646037
58FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.45136810
59GABP_19822575_ChIP-Seq_HepG2_Human1.44071437
60NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.41891262
61ZFP281_18757296_ChIP-ChIP_E14_Mouse1.41707215
62ATF3_27146783_Chip-Seq_COLON_Human1.40681385
63CLOCK_20551151_ChIP-Seq_293T_Human1.40471172
64STAT3_1855785_ChIP-Seq_MESCs_Mouse1.39692592
65ZFX_18555785_ChIP-Seq_MESCs_Mouse1.39189020
66YY1_22570637_ChIP-Seq_MALME-3M_Human1.38998171
67DCP1A_22483619_ChIP-Seq_HELA_Human1.38386112
68CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.38000265
69RACK7_27058665_Chip-Seq_MCF-7_Human1.37403168
70KLF4_18555785_ChIP-Seq_MESCs_Mouse1.36789871
71TCF7_22412390_ChIP-Seq_EML_Mouse1.36721843
72MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.36053576
73P68_20966046_ChIP-Seq_HELA_Human1.35948419
74TCF3_18692474_ChIP-Seq_MEFs_Mouse1.35791582
75CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.35658061
76* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.35230677
77* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.34922499
78CTCF_27219007_Chip-Seq_ERYTHROID_Human1.32467084
79CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.31760516
80E2F1_18555785_ChIP-Seq_MESCs_Mouse1.31433284
81SMC4_20622854_ChIP-Seq_HELA_Human1.30496398
82RARG_19884340_ChIP-ChIP_MEFs_Mouse1.30023988
83POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.29489916
84CTCF_27219007_Chip-Seq_Bcells_Human1.28778334
85TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.27174572
86TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.26103460
87RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.24158344
88SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.23966920
89TP53_22127205_ChIP-Seq_IMR90_Human1.23189424
90HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.22981718
91GABP_17652178_ChIP-ChIP_JURKAT_Human1.22902674
92TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.22417518
93NANOG_21062744_ChIP-ChIP_HESCs_Human1.22060967
94PPARA_22158963_ChIP-Seq_LIVER_Mouse1.21687483
95SOX2_18555785_ChIP-Seq_MESCs_Mouse1.21326415
96ELK3_25401928_ChIP-Seq_HUVEC_Human1.21112457
97* SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.21076616
98NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.20642232
99OCT4_18692474_ChIP-Seq_MEFs_Mouse1.18968235
100P63_26484246_Chip-Seq_KERATINOCYTES_Human1.18904301
101SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.18785012
102FOXP1_21924763_ChIP-Seq_HESCs_Human1.18675050
103CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.18555113
104CDX2_20551321_ChIP-Seq_CACO-2_Human1.18492322
105TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.17962422
106* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.17552790
107NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.16892116
108CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.15001500
109* LXR_22292898_ChIP-Seq_THP-1_Human1.14883597
110PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.14719634
111EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.14524898
112RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.13984160
113SOX2_18692474_ChIP-Seq_MEFs_Mouse1.13576801
114ESR1_21235772_ChIP-Seq_MCF-7_Human1.12648628
115ELF1_20517297_ChIP-Seq_JURKAT_Human1.12474169
116JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.12146595
117CREB1_26743006_Chip-Seq_LNCaP_Human1.10743632
118NFIB_24661679_ChIP-Seq_LUNG_Mouse1.10164623
119MYCN_18555785_ChIP-Seq_MESCs_Mouse1.09486939
120PHF8_20622854_ChIP-Seq_HELA_Human1.09475278
121TP63_22573176_ChIP-Seq_HFKS_Human1.09362063
122THAP11_20581084_ChIP-Seq_MESCs_Mouse1.08242739
123PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.07750387
124SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.07486335
125E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.07348835
126SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.07048462
127* SA1_27219007_Chip-Seq_Bcells_Human1.06865421
128* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.06643373
129GATA1_26923725_Chip-Seq_HPCs_Mouse1.06595593
130TTF2_22483619_ChIP-Seq_HELA_Human1.05710711
131E2F1_20622854_ChIP-Seq_HELA_Human1.05364057
132SOX2_27498859_Chip-Seq_STOMACH_Mouse1.05288306
133* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.05254500
134EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.04941699
135NCOR1_26117541_ChIP-Seq_K562_Human1.04442898
136BCOR_27268052_Chip-Seq_Bcells_Human1.04368205
137SA1_27219007_Chip-Seq_ERYTHROID_Human1.03750744
138RUNX1_27514584_Chip-Seq_MCF-7_Human1.03728674
139POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.03054143
140KDM5A_27292631_Chip-Seq_BREAST_Human1.02839800
141RARA_24833708_ChIP-Seq_LIVER_Mouse1.02511400
142CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.01900365
143GATA1_19941827_ChIP-Seq_MEL_Mouse1.01546674
144GATA1_22383799_ChIP-Seq_G1ME_Mouse1.01515482
145* GATA6_25053715_ChIP-Seq_YYC3_Human1.01295219
146POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.01098024
147SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.00988890
148SPI1_23127762_ChIP-Seq_K562_Human1.00958029
149VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.00920493
150NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.00731183
151E2F4_17652178_ChIP-ChIP_JURKAT_Human1.00485069
152* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.99534269
153ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.98565405
154CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.98512923
155BRD4_27068464_Chip-Seq_AML-cells_Mouse0.98484728
156BP1_19119308_ChIP-ChIP_Hs578T_Human0.98477124
157WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.98289303
158* IRF8_27001747_Chip-Seq_BMDM_Mouse0.98248154
159EST1_17652178_ChIP-ChIP_JURKAT_Human0.98027151
160SOX2_18692474_ChIP-Seq_MESCs_Mouse0.97999221
161TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97800873
162GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.97466988
163CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97221349
164GATA1_19941826_ChIP-Seq_K562_Human0.97063089
165BCL6_27268052_Chip-Seq_Bcells_Human0.96636542
166* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.93658950

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000566_synostosis5.66145201
2MP0005058_abnormal_lysosome_morphology4.70167617
3MP0010030_abnormal_orbit_morphology4.57425816
4MP0005360_urolithiasis4.30285149
5MP0003191_abnormal_cellular_cholesterol3.26034219
6MP0003693_abnormal_embryo_hatching2.96421879
7MP0000537_abnormal_urethra_morphology2.69492268
8MP0002653_abnormal_ependyma_morphology2.68241180
9MP0005451_abnormal_body_composition2.67150698
10MP0002089_abnormal_postnatal_growth/wei2.51376414
11MP0004858_abnormal_nervous_system2.41813337
12MP0003172_abnormal_lysosome_physiology2.39478284
13MP0009840_abnormal_foam_cell2.37179878
14MP0003111_abnormal_nucleus_morphology2.32959618
15MP0001666_abnormal_nutrient_absorption2.27024740
16MP0009053_abnormal_anal_canal2.16231284
17MP0002102_abnormal_ear_morphology2.01356529
18MP0003705_abnormal_hypodermis_morpholog2.00456986
19MP0005409_darkened_coat_color1.87623304
20MP0000678_abnormal_parathyroid_gland1.78215845
21MP0001730_embryonic_growth_arrest1.77852199
22MP0000462_abnormal_digestive_system1.77233677
23MP0003300_gastrointestinal_ulcer1.72895077
24MP0000604_amyloidosis1.70761510
25MP0005085_abnormal_gallbladder_physiolo1.68679251
26MP0003077_abnormal_cell_cycle1.67569799
27MP0003183_abnormal_peptide_metabolism1.65590086
28MP0003436_decreased_susceptibility_to1.61350232
29MP0002249_abnormal_larynx_morphology1.57965189
30MP0010234_abnormal_vibrissa_follicle1.57856179
31MP0008961_abnormal_basal_metabolism1.57641173
32MP0003119_abnormal_digestive_system1.54822349
33MP0003315_abnormal_perineum_morphology1.53407531
34MP0002998_abnormal_bone_remodeling1.52343671
35MP0003123_paternal_imprinting1.50214973
36MP0004957_abnormal_blastocyst_morpholog1.49450994
37MP0000049_abnormal_middle_ear1.47818712
38MP0004264_abnormal_extraembryonic_tissu1.47794525
39MP0000343_altered_response_to1.45586229
40MP0003718_maternal_effect1.45371958
41MP0008932_abnormal_embryonic_tissue1.44752748
42MP0000538_abnormal_urinary_bladder1.44634018
43MP0003938_abnormal_ear_development1.42301859
44MP0003329_amyloid_beta_deposits1.41426977
45MP0005257_abnormal_intraocular_pressure1.40952502
46MP0003453_abnormal_keratinocyte_physiol1.39906353
47MP0002139_abnormal_hepatobiliary_system1.39533960
48MP0003115_abnormal_respiratory_system1.39373716
49MP0004019_abnormal_vitamin_homeostasis1.38214801
50MP0003303_peritoneal_inflammation1.36526587
51MP0009278_abnormal_bone_marrow1.34601877
52MP0009780_abnormal_chondrocyte_physiolo1.34158599
53MP0010155_abnormal_intestine_physiology1.32867700
54MP0008438_abnormal_cutaneous_collagen1.29407807
55MP0005166_decreased_susceptibility_to1.29381219
56MP0000490_abnormal_crypts_of1.28467831
57MP0002085_abnormal_embryonic_tissue1.27979700
58MP0001849_ear_inflammation1.27972535
59MP0003075_altered_response_to1.27535560
60MP0006082_CNS_inflammation1.26238768
61MP0005380_embryogenesis_phenotype1.25510837
62MP0001672_abnormal_embryogenesis/_devel1.25510837
63MP0003937_abnormal_limbs/digits/tail_de1.25452573
64MP0003279_aneurysm1.24345159
65MP0005187_abnormal_penis_morphology1.24026758
66MP0003879_abnormal_hair_cell1.23187737
67MP0008004_abnormal_stomach_pH1.22109429
68MP0005377_hearing/vestibular/ear_phenot1.21762032
69MP0003878_abnormal_ear_physiology1.21762032
70MP0002796_impaired_skin_barrier1.20727535
71MP0000428_abnormal_craniofacial_morphol1.20656837
72MP0005670_abnormal_white_adipose1.20199439
73MP0003385_abnormal_body_wall1.20130603
74MP0009643_abnormal_urine_homeostasis1.19668359
75MP0002896_abnormal_bone_mineralization1.18892650
76MP0002254_reproductive_system_inflammat1.18833221
77MP0000858_altered_metastatic_potential1.18644951
78MP0000350_abnormal_cell_proliferation1.17208987
79MP0003984_embryonic_growth_retardation1.15920135
80MP0009379_abnormal_foot_pigmentation1.15722597
81MP0002088_abnormal_embryonic_growth/wei1.14820179
82MP0005365_abnormal_bile_salt1.14042614
83MP0003566_abnormal_cell_adhesion1.13829903
84MP0001533_abnormal_skeleton_physiology1.13806088
85MP0002118_abnormal_lipid_homeostasis1.13644307
86MP0008007_abnormal_cellular_replicative1.13471781
87MP0002098_abnormal_vibrissa_morphology1.12745081
88MP0008995_early_reproductive_senescence1.12643882
89MP0001697_abnormal_embryo_size1.12572094
90MP0001756_abnormal_urination1.12376456
91MP0003567_abnormal_fetal_cardiomyocyte1.12006207
92MP0002419_abnormal_innate_immunity1.09572402
93MP0004272_abnormal_basement_membrane1.09494007
94MP0002084_abnormal_developmental_patter1.08734205
95MP0004510_myositis1.08724966
96MP0003941_abnormal_skin_development1.04937452
97MP0005464_abnormal_platelet_physiology1.04521255
98MP0002111_abnormal_tail_morphology1.02033263
99MP0003221_abnormal_cardiomyocyte_apopto1.01702909
100MP0005501_abnormal_skin_physiology1.01262953
101MP0002086_abnormal_extraembryonic_tissu1.01118126
102MP0002080_prenatal_lethality1.00582491
103MP0000609_abnormal_liver_physiology1.00228637
104MP0005023_abnormal_wound_healing0.97842618
105MP0002282_abnormal_trachea_morphology0.97618861
106MP0005076_abnormal_cell_differentiation0.97126653
107MP0009764_decreased_sensitivity_to0.96880738
108MP0000477_abnormal_intestine_morphology0.96416605
109MP0008469_abnormal_protein_level0.94113115
110MP0008260_abnormal_autophagy0.93719379
111MP0003861_abnormal_nervous_system0.93152726
112MP0000534_abnormal_ureter_morphology0.92519113
113MP0003828_pulmonary_edema0.92422539
114MP0002092_abnormal_eye_morphology0.92359708
115MP0002233_abnormal_nose_morphology0.92063799
116MP0001529_abnormal_vocalization0.91334679
117MP0003122_maternal_imprinting0.90101057
118MP0003755_abnormal_palate_morphology0.90075768
119MP0005220_abnormal_exocrine_pancreas0.89857620
120MP0003091_abnormal_cell_migration0.87156533
121MP0005319_abnormal_enzyme/_coenzyme0.87134962
122MP0000579_abnormal_nail_morphology0.87130186
123MP0001663_abnormal_digestive_system0.86482620
124MP0005332_abnormal_amino_acid0.86280173
125MP0003935_abnormal_craniofacial_develop0.85194350
126MP0005025_abnormal_response_to0.85023942
127MP0002938_white_spotting0.84892109
128MP0000249_abnormal_blood_vessel0.84870181
129MP0001293_anophthalmia0.84324115
130MP0010352_gastrointestinal_tract_polyps0.84171692
131MP0002932_abnormal_joint_morphology0.83989992
132MP0004947_skin_inflammation0.83946875
133MP0001958_emphysema0.83363542
134MP0002148_abnormal_hypersensitivity_rea0.82637941
135MP0000681_abnormal_thyroid_gland0.82549333
136MP0002971_abnormal_brown_adipose0.82191429
137MP0010329_abnormal_lipoprotein_level0.82173371
138MP0001664_abnormal_digestion0.81769585
139MP0006276_abnormal_autonomic_nervous0.81659980
140MP0002136_abnormal_kidney_physiology0.81397095
141MP0000467_abnormal_esophagus_morphology0.81134983
142MP0005381_digestive/alimentary_phenotyp0.80699896
143MP0009250_abnormal_appendicular_skeleto0.80563444
144MP0005508_abnormal_skeleton_morphology0.80220502
145MP0001845_abnormal_inflammatory_respons0.80180512
146MP0003252_abnormal_bile_duct0.80061965
147MP0003868_abnormal_feces_composition0.79142777
148MP0005390_skeleton_phenotype0.78903917
149MP0005375_adipose_tissue_phenotype0.78844618
150MP0008875_abnormal_xenobiotic_pharmacok0.78461356
151MP0000003_abnormal_adipose_tissue0.78069697
152MP0006054_spinal_hemorrhage0.77864195
153MP0004197_abnormal_fetal_growth/weight/0.77004247
154MP0009672_abnormal_birth_weight0.76231839
155MP0005167_abnormal_blood-brain_barrier0.74419189
156MP0009785_altered_susceptibility_to0.73455420
157MP0000647_abnormal_sebaceous_gland0.72798166
158MP0005666_abnormal_adipose_tissue0.71104779
159MP0004185_abnormal_adipocyte_glucose0.71081740
160MP0000762_abnormal_tongue_morphology0.69867540
161MP0001764_abnormal_homeostasis0.69676813
162MP0002116_abnormal_craniofacial_bone0.69654868
163MP0009115_abnormal_fat_cell0.69635579
164MP0003942_abnormal_urinary_system0.68267190
165MP0000778_abnormal_nervous_system0.66920436
166MP0000767_abnormal_smooth_muscle0.66897379
167MP0003806_abnormal_nucleotide_metabolis0.66384230
168MP0003283_abnormal_digestive_organ0.65851754
169MP0003795_abnormal_bone_structure0.64728720
170MP0003634_abnormal_glial_cell0.62257134
171MP0001216_abnormal_epidermal_layer0.61548204
172MP0002933_joint_inflammation0.59993581

Predicted human phenotypes

RankGene SetZ-score
1Systemic lupus erythematosus (HP:0002725)4.89175654
2Abnormality of liposaccharide metabolism (HP:0010968)4.69376485
3Abnormality of glycosphingolipid metabolism (HP:0004343)4.69376485
4Abnormality of glycolipid metabolism (HP:0010969)4.69376485
5Vacuolated lymphocytes (HP:0001922)4.49579296
6Increased cerebral lipofuscin (HP:0011813)3.80630821
7Abnormality of proline metabolism (HP:0010907)3.72575800
8Hydroxyprolinuria (HP:0003080)3.72575800
9Axonal loss (HP:0003447)3.64624121
10Dysostosis multiplex (HP:0000943)3.61778992
11Xanthomatosis (HP:0000991)3.60590804
12Neonatal short-limb short stature (HP:0008921)3.56167281
13Right ventricular cardiomyopathy (HP:0011663)3.43696755
14Breast hypoplasia (HP:0003187)3.42164583
15Hyperglycinuria (HP:0003108)3.40257024
16Thin bony cortex (HP:0002753)3.35926466
17Increased neuronal autofluorescent lipopigment (HP:0002074)3.32987475
18Ileus (HP:0002595)3.30308559
19Deep venous thrombosis (HP:0002625)3.25362931
20Abnormality of mucopolysaccharide metabolism (HP:0011020)3.22673630
21Abnormality of polysaccharide metabolism (HP:0011012)3.22673630
22Abnormality of glycosaminoglycan metabolism (HP:0004371)3.22673630
23Hemorrhage of the eye (HP:0011885)3.19244185
24Complement deficiency (HP:0004431)3.08925051
25Urinary glycosaminoglycan excretion (HP:0003541)3.03824913
26Mucopolysacchariduria (HP:0008155)3.03824913
27Abnormality of complement system (HP:0005339)3.03723691
28High anterior hairline (HP:0009890)3.02130661
29Abnormality of macrophages (HP:0004311)2.96411347
30Malnutrition (HP:0004395)2.94756625
31Glomerulonephritis (HP:0000099)2.93040024
32Loss of speech (HP:0002371)2.83453949
33Ventricular tachycardia (HP:0004756)2.80871355
34Eczematoid dermatitis (HP:0000976)2.73941223
35Abnormality of serine family amino acid metabolism (HP:0010894)2.73626425
36Abnormality of glycine metabolism (HP:0010895)2.73626425
37Vertebral compression fractures (HP:0002953)2.71417504
38Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.70743152
39Microretrognathia (HP:0000308)2.68994837
40Hyperglycinemia (HP:0002154)2.67850492
41Widely patent fontanelles and sutures (HP:0004492)2.66650083
42Abnormality of the aortic arch (HP:0012303)2.63853443
43Neonatal death (HP:0003811)2.63620464
44Coronal craniosynostosis (HP:0004440)2.62792926
45Abnormality of the Achilles tendon (HP:0005109)2.60991241
46Abnormality of monocarboxylic acid metabolism (HP:0010996)2.59502195
47Down-sloping shoulders (HP:0200021)2.59123709
48Purpura (HP:0000979)2.56998989
49Impulsivity (HP:0100710)2.56882234
50Aplasia/Hypoplasia of the patella (HP:0006498)2.56317396
51Achilles tendon contracture (HP:0001771)2.56062005
52Abdominal distention (HP:0003270)2.53921857
53Protuberant abdomen (HP:0001538)2.53252563
54Progressive muscle weakness (HP:0003323)2.51413975
55Patellar aplasia (HP:0006443)2.48517820
56Partial duplication of thumb phalanx (HP:0009944)2.47814312
57Partial duplication of the phalanx of hand (HP:0009999)2.39552054
58Neurofibrillary tangles (HP:0002185)2.39258216
59Myocardial infarction (HP:0001658)2.38670624
60Bulbar palsy (HP:0001283)2.38323162
61Concave nail (HP:0001598)2.34479297
62Abnormal number of incisors (HP:0011064)2.34160866
63Bone pain (HP:0002653)2.33969988
64Abnormality of glutamine family amino acid metabolism (HP:0010902)2.33663696
65Ventricular fibrillation (HP:0001663)2.32104520
66Hypophosphatemia (HP:0002148)2.31989245
67Nuclear cataract (HP:0100018)2.30054560
68Bundle branch block (HP:0011710)2.29722737
69Metaphyseal irregularity (HP:0003025)2.26528491
70Asymmetric septal hypertrophy (HP:0001670)2.26195741
71Flat acetabular roof (HP:0003180)2.25834794
72Premature rupture of membranes (HP:0001788)2.25576115
73Prolonged neonatal jaundice (HP:0006579)2.23588800
74Selective tooth agenesis (HP:0001592)2.22498250
75Shawl scrotum (HP:0000049)2.22403216
76Cortical dysplasia (HP:0002539)2.19592341
77Pathologic fracture (HP:0002756)2.19065728
78Trismus (HP:0000211)2.17733345
79Amyloidosis (HP:0011034)2.16862440
80Distal upper limb amyotrophy (HP:0007149)2.15592730
81Upper limb amyotrophy (HP:0009129)2.15592730
82Nephritis (HP:0000123)2.14473949
83Disinhibition (HP:0000734)2.14451557
84Atrioventricular block (HP:0001678)2.14252359
85Short 4th metacarpal (HP:0010044)2.13583037
86Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.13583037
87Protrusio acetabuli (HP:0003179)2.13150893
88Cerebral aneurysm (HP:0004944)2.11070305
89Hypobetalipoproteinemia (HP:0003563)2.07799506
90Cervical subluxation (HP:0003308)2.06249249
91Distal lower limb muscle weakness (HP:0009053)2.06244558
92Visceral angiomatosis (HP:0100761)2.06109585
93Fat malabsorption (HP:0002630)2.05599532
94Recurrent bacterial skin infections (HP:0005406)2.05289654
95Syncope (HP:0001279)2.02904073
96Hyperacusis (HP:0010780)2.02615578
97Abnormality of the 4th metacarpal (HP:0010012)2.01984024
98Duplication of thumb phalanx (HP:0009942)2.00234228
99Renal duplication (HP:0000075)1.99310055
100Recurrent abscess formation (HP:0002722)1.97899019
101Femoral bowing (HP:0002980)1.97792698
102Recurrent gram-negative bacterial infections (HP:0005420)1.97747572
103Aplasia involving forearm bones (HP:0009822)1.97342927
104Absent forearm bone (HP:0003953)1.97342927
105Focal segmental glomerulosclerosis (HP:0000097)1.97169433
106Deep palmar crease (HP:0006191)1.96610902
107Hypercholesterolemia (HP:0003124)1.96548752
108Absent radius (HP:0003974)1.96445297
109Upper motor neuron abnormality (HP:0002127)1.95992366
110Gout (HP:0001997)1.95987507
111Distal lower limb amyotrophy (HP:0008944)1.95882952
112Difficulty climbing stairs (HP:0003551)1.95144153
113Ureteral duplication (HP:0000073)1.90189349
114J-shaped sella turcica (HP:0002680)1.90089796
115Broad hallux (HP:0010055)1.89256183
116Hyperparathyroidism (HP:0000843)1.89007075
117Gingivitis (HP:0000230)1.87553476
118Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.86610821
119Proximal placement of thumb (HP:0009623)1.84937321
120Hemangiomatosis (HP:0007461)1.84322436
121Birth length less than 3rd percentile (HP:0003561)1.83014632
122Neoplasm of the pancreas (HP:0002894)1.82604924
123Cerebral inclusion bodies (HP:0100314)1.82163850
124Premature ovarian failure (HP:0008209)1.81644858
125Cerebral hypomyelination (HP:0006808)1.80365224
126Peripheral demyelination (HP:0011096)1.80304761
127Multiple lipomas (HP:0001012)1.80050293
128Skull defect (HP:0001362)1.79534561
129Long toe (HP:0010511)1.79342921
130Hallux valgus (HP:0001822)1.79265566
131Hypolipoproteinemia (HP:0010981)1.78923393
132Deviation of the hallux (HP:0010051)1.78631225
133Delayed epiphyseal ossification (HP:0002663)1.78486879
134Abnormality of pyrimidine metabolism (HP:0004353)1.77862992
135Abnormality of alkaline phosphatase activity (HP:0004379)1.77384852
136Multiple enchondromatosis (HP:0005701)1.77078605
137Abnormality of the antihelix (HP:0009738)1.76526186
138Nephrolithiasis (HP:0000787)1.75031850
139Elevated alkaline phosphatase (HP:0003155)1.74496857
140Preaxial foot polydactyly (HP:0001841)1.74357595
141Increased serum ferritin (HP:0003281)1.74192093
142Megaloblastic anemia (HP:0001889)1.74181329
143Deviation of the thumb (HP:0009603)1.74059152
144Abnormality of the middle phalanges of the toes (HP:0010183)1.73815965
145Hypoplasia of the radius (HP:0002984)1.73069673
146Megalocornea (HP:0000485)1.73028963
147Shoulder girdle muscle weakness (HP:0003547)1.72928317
148Abnormal enzyme/coenzyme activity (HP:0012379)1.72522725
149Pelvic girdle muscle weakness (HP:0003749)1.72298845
150Atresia of the external auditory canal (HP:0000413)1.71774747
151Woolly hair (HP:0002224)1.71178173
152Stridor (HP:0010307)1.70101173
153Mitral stenosis (HP:0001718)1.69969590
154Broad toe (HP:0001837)1.69954118
155Disproportionate tall stature (HP:0001519)1.69331690
156Thoracic kyphosis (HP:0002942)1.68884998
157Hyperammonemia (HP:0001987)1.68837831
158Joint stiffness (HP:0001387)1.68466177
159Heart block (HP:0012722)1.68377349
160Ependymoma (HP:0002888)1.68203864
161Abnormality of the nasal mucosa (HP:0000433)1.67852825
162Angiofibromas (HP:0010615)1.67753299
163Adenoma sebaceum (HP:0009720)1.67753299
164Ventricular arrhythmia (HP:0004308)1.66576829
165Petechiae (HP:0000967)1.66250990
166Overriding aorta (HP:0002623)1.65152989
167Reticulocytopenia (HP:0001896)1.64725119
168Bronchomalacia (HP:0002780)1.64426849
169Hypoplastic toenails (HP:0001800)1.64260369
170Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.63694109
171Polycythemia (HP:0001901)1.62320474
172Abnormality of the thoracic spine (HP:0100711)1.61912728
173Elfin facies (HP:0004428)1.61646582
174Abnormality of the vitamin B12 metabolism (HP:0004341)1.61580028
175Germ cell neoplasia (HP:0100728)1.60847532
176Palpitations (HP:0001962)1.60820333
177Aneurysm (HP:0002617)1.60712694
178Hypertriglyceridemia (HP:0002155)1.60584069
179Synostosis involving bones of the hand (HP:0004278)1.60566124
180Rectal prolapse (HP:0002035)1.60550239
181Synostosis of carpal bones (HP:0005048)1.60519937
182Wide cranial sutures (HP:0010537)1.60036524
183Renal cell carcinoma (HP:0005584)1.59792846
184Retinal atrophy (HP:0001105)1.59784895
185Rickets (HP:0002748)1.59545973
186Abnormal ossification of hand bones (HP:0005921)1.59484096
187Skin nodule (HP:0200036)1.59339102
188Carpal synostosis (HP:0009702)1.58699071
189Uterine neoplasm (HP:0010784)1.58495294
190Fragile nails (HP:0001808)1.58148319
191Muscle fiber splitting (HP:0003555)1.58101779
192Abnormal atrioventricular conduction (HP:0005150)1.57795089
193Anal stenosis (HP:0002025)1.57684149
194Aplasia cutis congenita (HP:0001057)1.57601118

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.45174940
2MAP3K103.44321252
3EPHB23.34645991
4IRAK33.12899134
5PASK2.94439624
6STK38L2.71540407
7RIPK12.70894323
8SIK32.69374323
9PRPF4B2.37606821
10MST1R2.35882258
11LATS22.31885618
12NEK22.19340873
13TRIB32.13783141
14KSR12.13299523
15MAP2K22.07176425
16DYRK32.01233890
17PRKG21.97616029
18STK161.93994695
19LATS11.92002910
20WNK31.82841771
21PAK41.82330407
22PKN21.80207255
23TGFBR21.75937643
24EPHA21.72833743
25EEF2K1.62848344
26TLK11.60169615
27MAP2K31.58129594
28LMTK21.58087060
29CDC42BPA1.54508778
30DYRK21.52483181
31TESK21.48347627
32TTK1.45021209
33STK241.40326975
34ACVR1B1.39646041
35SMG11.35978284
36EPHB11.31809740
37BCR1.31087579
38MAPKAPK31.30728611
39MATK1.27499607
40FGFR11.22005085
41MARK11.19531083
42TAOK21.18726157
43PDPK11.16327789
44PRKCI1.15690625
45RPS6KA21.14370225
46MAP3K61.14273415
47MAP3K11.13711870
48ERN11.11771136
49PRKD21.11739302
50BRAF1.11295510
51TAOK11.09919835
52BCKDK1.08427082
53ABL21.08069900
54CDK41.07998381
55PLK11.06652144
56FGR1.06623885
57CAMK1D1.04242069
58PTK61.03221342
59BRSK10.99393458
60IRAK20.99326371
61STK30.98124493
62DDR20.95479615
63MAP3K30.93594426
64WEE10.91957547
65ICK0.91380263
66NME10.90635940
67TYK20.89556352
68PRKD30.89158623
69AURKA0.88310558
70UHMK10.87881615
71TBK10.87234164
72PIM20.87151878
73CDK80.85716114
74RPS6KC10.85382300
75RPS6KL10.85382300
76PTK20.84752519
77AKT20.83988135
78MET0.83574042
79PDGFRA0.83526025
80MAP3K110.83266153
81CSK0.82922612
82KSR20.82662775
83ZAP700.81886627
84NME20.80335710
85LIMK10.80212889
86ERBB20.79148165
87MARK20.78707186
88AURKB0.78510278
89SRPK10.78243470
90BLK0.77394397
91TYRO30.76331514
92BMX0.73651740
93CSF1R0.72887438
94PAK10.72308925
95MAPK110.71023436
96MARK30.70851148
97NEK10.68662143
98MAP3K80.68403688
99FGFR30.68181604
100RPS6KB20.64721813
101TESK10.64640055
102CAMKK10.64086928
103RPS6KA60.63963544
104IRAK10.63429600
105CDK70.63250303
106ERBB40.62002039
107MTOR0.61573233
108CSNK1G30.58692907
109MAP3K90.57674299
110ARAF0.57164569
111DYRK1B0.56784746
112FGFR40.56354131
113PRKCZ0.55176406
114CDC70.54208780
115PDK10.53980450
116SIK10.52831969
117PRKAA20.52047634
118CDK120.51956232
119PLK40.50111086
120RET0.49183774
121MELK0.47208112
122MAP2K60.46816880
123FGFR20.46669403
124CHEK20.45768207
125PDK30.45416630
126PDK40.45416630
127MAP3K50.44853751
128MAPK90.44761287
129STK100.44134476
130PAK30.44127480
131GRK60.44068898
132STK380.43759446
133MAP3K20.43271423
134IRAK40.42684345
135MAP4K10.42156444
136CSNK1G10.42072985
137PAK20.41910695
138MAP3K130.40833034
139PAK60.40148595
140CAMK1G0.39720750
141TTN0.39168435
142SRC0.39076945
143SIK20.38991476
144MYLK0.38983559
145KDR0.38791519
146RPS6KA10.38174995
147PRKD10.38097792
148MAP2K40.38068024
149EPHA30.37994791
150CDK180.37156737
151ROCK10.36802326
152HIPK20.36688733
153PRKAA10.36124327
154LRRK20.36021044
155CSNK1A1L0.36018636
156MAP3K140.34888071
157CHEK10.34549592
158GSK3A0.34018166
159FER0.33083792
160MOS0.30811170
161MAPKAPK20.30276558
162DAPK30.30071033
163RIPK40.28400687
164CHUK0.27377307

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005114.33568778
2Fat digestion and absorption_Homo sapiens_hsa049753.70667032
3Vitamin digestion and absorption_Homo sapiens_hsa049772.66517641
4Glycosaminoglycan degradation_Homo sapiens_hsa005312.38283709
5RNA polymerase_Homo sapiens_hsa030202.29878317
6Lysosome_Homo sapiens_hsa041422.26182727
7Spliceosome_Homo sapiens_hsa030402.24184531
8Renin-angiotensin system_Homo sapiens_hsa046142.22080337
9Basal cell carcinoma_Homo sapiens_hsa052172.11622913
10Folate biosynthesis_Homo sapiens_hsa007902.07775870
11Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.07328741
122-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.05718592
13RNA transport_Homo sapiens_hsa030131.91290877
14Notch signaling pathway_Homo sapiens_hsa043301.88529243
15Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.87167968
16Cell cycle_Homo sapiens_hsa041101.83102804
17Staphylococcus aureus infection_Homo sapiens_hsa051501.77703707
18Pyrimidine metabolism_Homo sapiens_hsa002401.77340637
19Vitamin B6 metabolism_Homo sapiens_hsa007501.74074828
20Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.72791295
21Complement and coagulation cascades_Homo sapiens_hsa046101.69869822
22Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.67818395
23Drug metabolism - other enzymes_Homo sapiens_hsa009831.62428550
24Sphingolipid metabolism_Homo sapiens_hsa006001.59821079
25Cyanoamino acid metabolism_Homo sapiens_hsa004601.59139911
26Hippo signaling pathway_Homo sapiens_hsa043901.57576635
27Arginine and proline metabolism_Homo sapiens_hsa003301.57175901
28Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.53425196
29Maturity onset diabetes of the young_Homo sapiens_hsa049501.49941118
30Bladder cancer_Homo sapiens_hsa052191.49575821
31Selenocompound metabolism_Homo sapiens_hsa004501.45834601
32Hedgehog signaling pathway_Homo sapiens_hsa043401.44461140
33Mineral absorption_Homo sapiens_hsa049781.42145708
34Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.41246849
35Carbon metabolism_Homo sapiens_hsa012001.38001170
36Sulfur relay system_Homo sapiens_hsa041221.36530182
37DNA replication_Homo sapiens_hsa030301.34654835
38Biosynthesis of amino acids_Homo sapiens_hsa012301.32300576
39mRNA surveillance pathway_Homo sapiens_hsa030151.31153282
40Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.29724313
41Galactose metabolism_Homo sapiens_hsa000521.29333957
42Fructose and mannose metabolism_Homo sapiens_hsa000511.29323534
43Fatty acid degradation_Homo sapiens_hsa000711.27641191
44Proteasome_Homo sapiens_hsa030501.26695896
45Pentose phosphate pathway_Homo sapiens_hsa000301.25818795
46Glutathione metabolism_Homo sapiens_hsa004801.25194577
47Pentose and glucuronate interconversions_Homo sapiens_hsa000401.20801708
48Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.19677669
49Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.15434100
50Prion diseases_Homo sapiens_hsa050201.15301470
51Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.14300217
52Tryptophan metabolism_Homo sapiens_hsa003801.08835070
53Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.08469838
54Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.06976231
55Base excision repair_Homo sapiens_hsa034101.05635707
56Ribosome_Homo sapiens_hsa030101.04585079
57Butanoate metabolism_Homo sapiens_hsa006501.04354346
58Protein digestion and absorption_Homo sapiens_hsa049741.02645916
59p53 signaling pathway_Homo sapiens_hsa041151.01805700
60Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.01643125
61MicroRNAs in cancer_Homo sapiens_hsa052061.00728395
62Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.00648138
63Chemical carcinogenesis_Homo sapiens_hsa052041.00348944
64Lysine degradation_Homo sapiens_hsa003100.99947186
65Pertussis_Homo sapiens_hsa051330.98075342
66Glycerolipid metabolism_Homo sapiens_hsa005610.97530522
67Vibrio cholerae infection_Homo sapiens_hsa051100.94381741
68Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.93688945
69Osteoclast differentiation_Homo sapiens_hsa043800.89913512
70Purine metabolism_Homo sapiens_hsa002300.89771384
71Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.88800177
72Steroid hormone biosynthesis_Homo sapiens_hsa001400.88444539
73Tight junction_Homo sapiens_hsa045300.87718613
74Phagosome_Homo sapiens_hsa041450.87542895
75Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.86287773
76Bile secretion_Homo sapiens_hsa049760.86093694
77Sulfur metabolism_Homo sapiens_hsa009200.83943553
78Phenylalanine metabolism_Homo sapiens_hsa003600.83878956
79Leishmaniasis_Homo sapiens_hsa051400.83113550
80Central carbon metabolism in cancer_Homo sapiens_hsa052300.82599492
81Salmonella infection_Homo sapiens_hsa051320.81940031
82Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.81341461
83Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.79800740
84Arginine biosynthesis_Homo sapiens_hsa002200.76482014
85Endometrial cancer_Homo sapiens_hsa052130.75472670
86Rheumatoid arthritis_Homo sapiens_hsa053230.74809058
87Amoebiasis_Homo sapiens_hsa051460.72439872
88Glycerophospholipid metabolism_Homo sapiens_hsa005640.71994248
89Starch and sucrose metabolism_Homo sapiens_hsa005000.71143997
90Tuberculosis_Homo sapiens_hsa051520.71013078
91Oocyte meiosis_Homo sapiens_hsa041140.70970659
92Arachidonic acid metabolism_Homo sapiens_hsa005900.70749403
93Leukocyte transendothelial migration_Homo sapiens_hsa046700.69851839
94Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.68469420
95Regulation of autophagy_Homo sapiens_hsa041400.67633885
96Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.65843354
97Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.65495919
98Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.65424956
99Basal transcription factors_Homo sapiens_hsa030220.65008075
100PPAR signaling pathway_Homo sapiens_hsa033200.64761354
101Thyroid cancer_Homo sapiens_hsa052160.63457581
102Hepatitis C_Homo sapiens_hsa051600.61926615
103Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.61925524
104Acute myeloid leukemia_Homo sapiens_hsa052210.60672466
105Adipocytokine signaling pathway_Homo sapiens_hsa049200.60400714
106TNF signaling pathway_Homo sapiens_hsa046680.59047176
107Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.58078116
108Fatty acid metabolism_Homo sapiens_hsa012120.57124291
109AMPK signaling pathway_Homo sapiens_hsa041520.56559285
110Propanoate metabolism_Homo sapiens_hsa006400.56428550
111Carbohydrate digestion and absorption_Homo sapiens_hsa049730.56069374
112beta-Alanine metabolism_Homo sapiens_hsa004100.55936632
113Retinol metabolism_Homo sapiens_hsa008300.55843937
114Chronic myeloid leukemia_Homo sapiens_hsa052200.55269186
115Toll-like receptor signaling pathway_Homo sapiens_hsa046200.55148946
116Histidine metabolism_Homo sapiens_hsa003400.54180765
117TGF-beta signaling pathway_Homo sapiens_hsa043500.53648001
118Collecting duct acid secretion_Homo sapiens_hsa049660.53440926
119Cysteine and methionine metabolism_Homo sapiens_hsa002700.51686140
120Primary bile acid biosynthesis_Homo sapiens_hsa001200.51485499
121Small cell lung cancer_Homo sapiens_hsa052220.51234985
122Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.50839074
123Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.50709511
124Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.50246689
125Asthma_Homo sapiens_hsa053100.49778737
126Colorectal cancer_Homo sapiens_hsa052100.49260275
127Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.48574519
128Insulin resistance_Homo sapiens_hsa049310.48387927
129Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.48193720
130Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.48187885
131Toxoplasmosis_Homo sapiens_hsa051450.47598098
132HTLV-I infection_Homo sapiens_hsa051660.46323497
133Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.44566532
134VEGF signaling pathway_Homo sapiens_hsa043700.44442640
135Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.44376161
136GnRH signaling pathway_Homo sapiens_hsa049120.44147147
137Linoleic acid metabolism_Homo sapiens_hsa005910.43614761
138Thyroid hormone signaling pathway_Homo sapiens_hsa049190.42998997
139Nucleotide excision repair_Homo sapiens_hsa034200.42566999
140Mismatch repair_Homo sapiens_hsa034300.42251794
141Wnt signaling pathway_Homo sapiens_hsa043100.41847786
142Sphingolipid signaling pathway_Homo sapiens_hsa040710.41493418
143Caffeine metabolism_Homo sapiens_hsa002320.41228758
144Epstein-Barr virus infection_Homo sapiens_hsa051690.41191316
145Endocytosis_Homo sapiens_hsa041440.40712588
146Ether lipid metabolism_Homo sapiens_hsa005650.39355080
147Metabolic pathways_Homo sapiens_hsa011000.38640348
148AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.38374775
149Cardiac muscle contraction_Homo sapiens_hsa042600.38045667
150Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.38022562
151Pathways in cancer_Homo sapiens_hsa052000.37479555
152Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.36121706
153alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.36112745
154One carbon pool by folate_Homo sapiens_hsa006700.36103790
155Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.35745443
156Focal adhesion_Homo sapiens_hsa045100.31644677

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