FAM109B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protoporphyrinogen IX metabolic process (GO:0046501)7.81631881
2protoporphyrinogen IX biosynthetic process (GO:0006782)7.25939077
3ribosomal small subunit assembly (GO:0000028)7.18701789
4definitive hemopoiesis (GO:0060216)5.61830696
5heme biosynthetic process (GO:0006783)5.59590223
6viral transcription (GO:0019083)5.48788819
7porphyrin-containing compound biosynthetic process (GO:0006779)5.32555873
8translational termination (GO:0006415)5.29447409
9erythrocyte maturation (GO:0043249)5.12947232
10DNA strand elongation involved in DNA replication (GO:0006271)4.87133109
11telomere maintenance via semi-conservative replication (GO:0032201)4.72630621
12extracellular fibril organization (GO:0043206)4.70529944
13translational elongation (GO:0006414)4.69939757
14DNA deamination (GO:0045006)4.67995706
15DNA strand elongation (GO:0022616)4.67018721
16tetrapyrrole biosynthetic process (GO:0033014)4.66912945
17ribosomal small subunit biogenesis (GO:0042274)4.61052274
18SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.57576733
19protein heterotrimerization (GO:0070208)4.55448867
20barbed-end actin filament capping (GO:0051016)4.53986362
21skin morphogenesis (GO:0043589)4.53133408
22cotranslational protein targeting to membrane (GO:0006613)4.45790386
23protein targeting to ER (GO:0045047)4.43626840
24fibril organization (GO:0097435)4.38621890
25heme metabolic process (GO:0042168)4.36997502
26maturation of SSU-rRNA (GO:0030490)4.33091439
27nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.22004488
28establishment of protein localization to endoplasmic reticulum (GO:0072599)4.21730151
29porphyrin-containing compound metabolic process (GO:0006778)4.17930644
30protein localization to endoplasmic reticulum (GO:0070972)4.16067596
31telomere maintenance via recombination (GO:0000722)4.14644984
32cellular protein complex disassembly (GO:0043624)4.11838299
33DNA replication initiation (GO:0006270)4.11747463
34DNA unwinding involved in DNA replication (GO:0006268)4.05545764
35adhesion of symbiont to host cell (GO:0044650)4.03833787
36virion attachment to host cell (GO:0019062)4.03833787
37viral life cycle (GO:0019058)4.00481301
38blood vessel maturation (GO:0001955)3.92442542
39translational initiation (GO:0006413)3.87980830
40megakaryocyte development (GO:0035855)3.83934676
41collagen fibril organization (GO:0030199)3.83346183
42mitotic recombination (GO:0006312)3.79931914
43embryonic hemopoiesis (GO:0035162)3.75769350
44protein complex disassembly (GO:0043241)3.75718802
45hyaluronan catabolic process (GO:0030214)3.74381726
46stress fiber assembly (GO:0043149)3.74149159
47erythrocyte development (GO:0048821)3.73020016
48type B pancreatic cell proliferation (GO:0044342)3.70746357
49endodermal cell differentiation (GO:0035987)3.69831083
50regulation of erythrocyte differentiation (GO:0045646)3.69352743
51pinocytosis (GO:0006907)3.63527539
52deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.60379408
53adhesion of symbiont to host (GO:0044406)3.51887051
54CENP-A containing nucleosome assembly (GO:0034080)3.51558405
55IMP biosynthetic process (GO:0006188)3.50106027
56sequestering of extracellular ligand from receptor (GO:0035581)3.49302416
57cell migration involved in heart development (GO:0060973)3.49122710
58macromolecular complex disassembly (GO:0032984)3.48072661
59erythrocyte differentiation (GO:0030218)3.47535439
60basement membrane organization (GO:0071711)3.43395647
61telomere maintenance via telomere lengthening (GO:0010833)3.41269828
62positive regulation of endothelial cell apoptotic process (GO:2000353)3.40243301
63Golgi transport vesicle coating (GO:0048200)3.35568981
64COPI coating of Golgi vesicle (GO:0048205)3.35568981
65ribosomal large subunit biogenesis (GO:0042273)3.32396296
66collagen metabolic process (GO:0032963)3.30476087
67negative regulation of smooth muscle cell migration (GO:0014912)3.29667057
68DNA replication checkpoint (GO:0000076)3.29532050
69nuclear-transcribed mRNA catabolic process (GO:0000956)3.29183687
70granulocyte differentiation (GO:0030851)3.28514581
71regulation of integrin-mediated signaling pathway (GO:2001044)3.27512041
72myeloid cell development (GO:0061515)3.26661147
73nucleotide-excision repair, DNA gap filling (GO:0006297)3.23945749
74positive regulation of erythrocyte differentiation (GO:0045648)3.23418917
75chromatin remodeling at centromere (GO:0031055)3.22825331
76negative regulation of erythrocyte differentiation (GO:0045647)3.22588739
77extracellular matrix assembly (GO:0085029)3.22015630
78kinetochore organization (GO:0051383)3.18465867
79antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.17840109
80collagen catabolic process (GO:0030574)3.17446831
81keratan sulfate catabolic process (GO:0042340)3.16922680
82protein localization to endosome (GO:0036010)3.14845537
83protein retention in ER lumen (GO:0006621)3.13654877
84mRNA catabolic process (GO:0006402)3.13487349
85apoptotic cell clearance (GO:0043277)3.12867789
86positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.11497841
87positive regulation of B cell differentiation (GO:0045579)3.10642014
88regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.08792867
89antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.08300799
90antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.08300799
91positive regulation of osteoblast proliferation (GO:0033690)3.08022517
92DNA replication-independent nucleosome organization (GO:0034724)3.07711449
93DNA replication-independent nucleosome assembly (GO:0006336)3.07711449
94multicellular organismal macromolecule metabolic process (GO:0044259)3.07093073
95RNA catabolic process (GO:0006401)3.05778251
96IMP metabolic process (GO:0046040)3.05600567
97regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.04628649
98negative regulation of nitric oxide biosynthetic process (GO:0045019)3.01047232
99regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.99959524
100antigen processing and presentation via MHC class Ib (GO:0002475)2.99536257
101positive regulation of odontogenesis (GO:0042482)2.99421431
102extracellular matrix disassembly (GO:0022617)2.99114233
103multicellular organismal catabolic process (GO:0044243)2.98174401
104protein targeting to membrane (GO:0006612)2.96944205
105endothelium development (GO:0003158)2.96474589
106platelet dense granule organization (GO:0060155)2.95559631
107regulation of early endosome to late endosome transport (GO:2000641)2.95070548
108maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.92126206
109telomere maintenance (GO:0000723)2.91282660
110vascular endothelial growth factor signaling pathway (GO:0038084)2.90529878
111multicellular organismal metabolic process (GO:0044236)2.88847034
112positive regulation of receptor recycling (GO:0001921)2.88634541
113hypotonic response (GO:0006971)2.87968977
114purine-containing compound salvage (GO:0043101)2.87824373
115ribonucleoprotein complex biogenesis (GO:0022613)2.87641087
116telomere organization (GO:0032200)2.87483913
117negative regulation of homotypic cell-cell adhesion (GO:0034111)2.85984018
118bone trabecula formation (GO:0060346)2.85591032
119regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.85485968
120cell-substrate junction assembly (GO:0007044)2.85210111
121translation (GO:0006412)2.84375160
122one-carbon compound transport (GO:0019755)2.84108379
123negative regulation of adherens junction organization (GO:1903392)2.83854856
124negative regulation of focal adhesion assembly (GO:0051895)2.83854856
125negative regulation of cell junction assembly (GO:1901889)2.83854856
126wound healing, spreading of epidermal cells (GO:0035313)2.81235126
127chondrocyte proliferation (GO:0035988)2.78674122
128kinetochore assembly (GO:0051382)2.77248455
129platelet aggregation (GO:0070527)2.74535165
130angiogenesis involved in wound healing (GO:0060055)2.74401823
131regulation of metalloenzyme activity (GO:0048552)2.73534414
132pigment biosynthetic process (GO:0046148)2.73170762
133negative regulation of RNA splicing (GO:0033119)2.71357246
134UV protection (GO:0009650)2.70224801
135regulation of extracellular matrix disassembly (GO:0010715)2.69978168
136tooth mineralization (GO:0034505)2.69477865
137regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.68679555
138endothelial cell morphogenesis (GO:0001886)2.66091925
139substrate-dependent cell migration (GO:0006929)2.66069423
140pseudouridine synthesis (GO:0001522)2.65674702
141hematopoietic stem cell differentiation (GO:0060218)2.65317674
142tetrapyrrole metabolic process (GO:0033013)2.64159366
143positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.64159133
144negative regulation of protein localization to plasma membrane (GO:1903077)2.62964479
145cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.62152116
146negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.61717761
147maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.60009436
148formation of translation preinitiation complex (GO:0001731)2.59676281
149meiotic chromosome segregation (GO:0045132)2.59167098
150regulation of DNA endoreduplication (GO:0032875)2.58603279
151hemoglobin metabolic process (GO:0020027)2.58558969
152protein localization to chromosome, centromeric region (GO:0071459)2.58029341
153mitotic nuclear envelope disassembly (GO:0007077)2.57586789
154translesion synthesis (GO:0019985)2.57206387
155cellular response to vitamin (GO:0071295)2.56962932
156positive regulation of blood vessel endothelial cell migration (GO:0043536)2.56625704
157kidney mesenchyme development (GO:0072074)2.55321247
158decidualization (GO:0046697)2.54687421
159rRNA processing (GO:0006364)2.52601324
160attachment of spindle microtubules to kinetochore (GO:0008608)2.52316442
161regulation of integrin activation (GO:0033623)2.52249536
162cyclooxygenase pathway (GO:0019371)2.52118792
163atrioventricular valve morphogenesis (GO:0003181)2.51272670
164epithelial cell-cell adhesion (GO:0090136)2.51219729
1653-UTR-mediated mRNA stabilization (GO:0070935)2.50733602
166peptidyl-proline hydroxylation (GO:0019511)2.50687291
167positive regulation of gamma-delta T cell activation (GO:0046645)2.50235464
168histone exchange (GO:0043486)2.49845796
169cell adhesion mediated by integrin (GO:0033627)2.47038907
170regulation of nuclear cell cycle DNA replication (GO:0033262)2.46978635
171rRNA metabolic process (GO:0016072)2.45518331
172negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.44771091
173mitotic chromosome condensation (GO:0007076)2.44646648
174extracellular matrix organization (GO:0030198)2.44329289
175metanephric mesenchyme development (GO:0072075)2.44218459
176iron-sulfur cluster assembly (GO:0016226)2.44032699
177metallo-sulfur cluster assembly (GO:0031163)2.44032699
178extracellular structure organization (GO:0043062)2.43576910
179negative regulation of bone mineralization (GO:0030502)2.42302362
180regulation of collagen metabolic process (GO:0010712)2.41250240
181chondroitin sulfate biosynthetic process (GO:0030206)2.39772461
182positive regulation of Cdc42 GTPase activity (GO:0043089)2.39079990
183dermatan sulfate metabolic process (GO:0030205)2.38309911
184regulation of monocyte chemotaxis (GO:0090025)2.37172750
185extracellular regulation of signal transduction (GO:1900115)2.36341043
186extracellular negative regulation of signal transduction (GO:1900116)2.36341043
187endocardial cushion development (GO:0003197)2.35831559
188negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.35524440
189wound healing, spreading of cells (GO:0044319)2.35429488
190phagocytosis, engulfment (GO:0006911)2.35052241
191response to magnesium ion (GO:0032026)2.34436112
192negative regulation of platelet activation (GO:0010544)2.34257448
193cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.33802920
194regulation of transforming growth factor beta1 production (GO:0032908)2.33076374
195regulation of membrane protein ectodomain proteolysis (GO:0051043)2.33029865
196response to laminar fluid shear stress (GO:0034616)2.32173442
197regulation of platelet aggregation (GO:0090330)2.30206191
198protein hydroxylation (GO:0018126)2.29009859

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.65785586
2RARG_19884340_ChIP-ChIP_MEFs_Mouse4.76909089
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.57432169
4GATA1_22025678_ChIP-Seq_K562_Human3.52103147
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.42881868
6SCL_19346495_ChIP-Seq_HPC-7_Human3.32428308
7FOXM1_23109430_ChIP-Seq_U2OS_Human3.32210392
8MYC_18555785_ChIP-Seq_MESCs_Mouse3.28491687
9PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.16117047
10TRIM28_21343339_ChIP-Seq_HEK293_Human3.14208795
11TP63_17297297_ChIP-ChIP_HaCaT_Human3.00969250
12TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.00239444
13TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.99065004
14ELK3_25401928_ChIP-Seq_HUVEC_Human2.93188263
15SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.82541194
16FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.67529258
17ELF1_17652178_ChIP-ChIP_JURKAT_Human2.56626713
18SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.56380955
19* TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.53015468
20RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.50901967
21HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.43256852
22LXR_22292898_ChIP-Seq_THP-1_Human2.31697524
23MYC_18358816_ChIP-ChIP_MESCs_Mouse2.27669505
24KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.22016223
25EST1_17652178_ChIP-ChIP_JURKAT_Human2.19273666
26NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.18856850
27NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.17772391
28* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.15208525
29THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.15195532
30TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse2.12524085
31MYC_19030024_ChIP-ChIP_MESCs_Mouse2.06467897
32GATA2_21666600_ChIP-Seq_HMVEC_Human2.05617789
33GABP_17652178_ChIP-ChIP_JURKAT_Human2.05065060
34HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.01267467
35MYC_19079543_ChIP-ChIP_MESCs_Mouse2.00648499
36ETS1_20019798_ChIP-Seq_JURKAT_Human1.99742979
37CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.99583775
38EGR1_19374776_ChIP-ChIP_THP-1_Human1.95919487
39* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.95332398
40VDR_23849224_ChIP-Seq_CD4+_Human1.94995510
41CLOCK_20551151_ChIP-Seq_293T_Human1.93456245
42HOXB4_20404135_ChIP-ChIP_EML_Mouse1.91740336
43* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.90404179
44* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.89044002
45ERG_20887958_ChIP-Seq_HPC-7_Mouse1.89023209
46JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.87285249
47RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.82787003
48NELFA_20434984_ChIP-Seq_ESCs_Mouse1.81809896
49RACK7_27058665_Chip-Seq_MCF-7_Human1.79482243
50XRN2_22483619_ChIP-Seq_HELA_Human1.77885608
51KDM2B_26808549_Chip-Seq_SUP-B15_Human1.77759000
52CREB1_15753290_ChIP-ChIP_HEK293T_Human1.77517781
53MYC_22102868_ChIP-Seq_BL_Human1.76356346
54E2F1_21310950_ChIP-Seq_MCF-7_Human1.76004485
55FOXP3_21729870_ChIP-Seq_TREG_Human1.75160885
56VDR_21846776_ChIP-Seq_THP-1_Human1.74895500
57GATA1_19941827_ChIP-Seq_MEL_Mouse1.73555950
58ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.73479221
59NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.72367304
60SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.68186856
61MYB_21317192_ChIP-Seq_ERMYB_Mouse1.66771542
62AR_21909140_ChIP-Seq_LNCAP_Human1.66071604
63GATA1_19941826_ChIP-Seq_K562_Human1.65195321
64IRF8_22096565_ChIP-ChIP_GC-B_Human1.64493181
65* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.61630824
66KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.59574152
67ESR2_21235772_ChIP-Seq_MCF-7_Human1.58854964
68CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.58540577
69SRF_21415370_ChIP-Seq_HL-1_Mouse1.57241798
70MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.56838713
71CIITA_25753668_ChIP-Seq_RAJI_Human1.56510388
72KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.55368800
73IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.54755152
74HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.52864496
75TTF2_22483619_ChIP-Seq_HELA_Human1.52523187
76NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.51673667
77FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.51070730
78NOTCH1_21737748_ChIP-Seq_TLL_Human1.50728051
79UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.50419116
80TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.49656491
81E2F1_18555785_ChIP-Seq_MESCs_Mouse1.49473912
82ELK1_19687146_ChIP-ChIP_HELA_Human1.47521888
83MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.47256101
84SMC1_22415368_ChIP-Seq_MEFs_Mouse1.47108435
85TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.46456026
86MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.45872871
87DCP1A_22483619_ChIP-Seq_HELA_Human1.45749419
88PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.45600877
89SPI1_23547873_ChIP-Seq_NB4_Human1.44918846
90PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.43007158
91KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.42945891
92SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.41135828
93BRD4_25478319_ChIP-Seq_HGPS_Human1.40907269
94SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.37948741
95CTCF_27219007_Chip-Seq_ERYTHROID_Human1.37104448
96THAP11_20581084_ChIP-Seq_MESCs_Mouse1.36939242
97* LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.36746169
98JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.36736876
99P300_27058665_Chip-Seq_ZR-75-30cells_Human1.35478923
100Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.34773479
101* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.34707010
102P63_26484246_Chip-Seq_KERATINOCYTES_Human1.34664640
103ZNF263_19887448_ChIP-Seq_K562_Human1.34535287
104SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.33692192
105TP53_22127205_ChIP-Seq_IMR90_Human1.33352675
106SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.33258158
107SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.33258158
108GABP_19822575_ChIP-Seq_HepG2_Human1.30971026
109* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.28529506
110KDM2B_26808549_Chip-Seq_DND41_Human1.27334683
111* RUNX1_22412390_ChIP-Seq_EML_Mouse1.26982818
112SMC3_22415368_ChIP-Seq_MEFs_Mouse1.26219005
113ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.25789779
114JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.25275147
115STAT4_19710469_ChIP-ChIP_TH1__Mouse1.25032021
116ZFX_18555785_ChIP-Seq_MESCs_Mouse1.24951079
117* KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.24550688
118TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.23959641
119GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.22412969
120STAT6_21828071_ChIP-Seq_BEAS2B_Human1.21936338
121ATF3_27146783_Chip-Seq_COLON_Human1.21765521
122HIF1A_21447827_ChIP-Seq_MCF-7_Human1.21282666
123KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.20789880
124SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.19698855
125YY1_21170310_ChIP-Seq_MESCs_Mouse1.18958972
126ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.18680450
127UBF1/2_26484160_Chip-Seq_HMECs_Human1.18430801
128CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.17484343
129VDR_24763502_ChIP-Seq_THP-1_Human1.15965513
130TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15666235
131HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.14868244
132SA1_27219007_Chip-Seq_ERYTHROID_Human1.14851758
133MAF_26560356_Chip-Seq_TH1_Human1.13917942
134NFIB_24661679_ChIP-Seq_LUNG_Mouse1.13813704
135SMAD_19615063_ChIP-ChIP_OVARY_Human1.13552213
136MYCN_18555785_ChIP-Seq_MESCs_Mouse1.12808424
137CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.12235061
138BP1_19119308_ChIP-ChIP_Hs578T_Human1.12234722
139TBX20_22328084_ChIP-Seq_HEART_Mouse1.10111568
140TBX20_22080862_ChIP-Seq_HEART_Mouse1.10111568
141SPI1_23127762_ChIP-Seq_K562_Human1.09610179
142PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.09084828
143BRD4_27068464_Chip-Seq_AML-cells_Mouse1.08729641
144MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.08383656
145WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.08332809
146MYB_26560356_Chip-Seq_TH2_Human1.07541635
147SOX9_24532713_ChIP-Seq_HFSC_Mouse1.07500014
148ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.07058022
149* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.07047736
150IRF8_27001747_Chip-Seq_BMDM_Mouse1.06982771
151TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.06762992
152CJUN_26792858_Chip-Seq_BT549_Human1.06615731
153SRY_22984422_ChIP-ChIP_TESTIS_Rat1.06063287
154UTX_26944678_Chip-Seq_JUKART_Human1.06053130
155ELF1_20517297_ChIP-Seq_JURKAT_Human1.05244406
156E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.04841821
157TET1_21451524_ChIP-Seq_MESCs_Mouse1.03699990
158PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03585751
159STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.03173351
160PPAR_26484153_Chip-Seq_NCI-H1993_Human1.01657869
161NCOR1_26117541_ChIP-Seq_K562_Human1.01393649
162ESR1_21235772_ChIP-Seq_MCF-7_Human1.00104063
163TFEB_21752829_ChIP-Seq_HELA_Human0.99732569
164SA1_22415368_ChIP-Seq_MEFs_Mouse0.99168921
165ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.98805894
166SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.98652240
167FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.98190765
168CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.98189985
169MYB_26560356_Chip-Seq_TH1_Human0.95939704
170CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.95242441
171TCF7_22412390_ChIP-Seq_EML_Mouse0.93934787
172KDM5A_27292631_Chip-Seq_BREAST_Human0.93110299
173RBPJ_22232070_ChIP-Seq_NCS_Mouse0.92196485
174GATA2_19941826_ChIP-Seq_K562_Human0.91780711
175YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.89133644
176MAF_26560356_Chip-Seq_TH2_Human0.87230421
177IRF8_21731497_ChIP-ChIP_J774_Mouse0.85333030

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen6.86480091
2MP0004147_increased_porphyrin_level6.20581827
3MP0003656_abnormal_erythrocyte_physiolo5.72464052
4MP0002396_abnormal_hematopoietic_system4.34938135
5MP0003705_abnormal_hypodermis_morpholog3.91549838
6MP0005275_abnormal_skin_tensile3.87689015
7MP0005503_abnormal_tendon_morphology3.69302812
8MP0003279_aneurysm3.59995563
9MP0006054_spinal_hemorrhage3.49961188
10MP0010094_abnormal_chromosome_stability3.29023980
11MP0001958_emphysema3.28361561
12MP0004272_abnormal_basement_membrane3.04917648
13MP0003111_abnormal_nucleus_morphology2.99342218
14MP0005397_hematopoietic_system_phenotyp2.91493286
15MP0001545_abnormal_hematopoietic_system2.91493286
16MP0005257_abnormal_intraocular_pressure2.78630966
17MP0008057_abnormal_DNA_replication2.75234092
18MP0003693_abnormal_embryo_hatching2.66746483
19MP0004808_abnormal_hematopoietic_stem2.44101376
20MP0003077_abnormal_cell_cycle2.40983068
21MP0005058_abnormal_lysosome_morphology2.25937353
22MP0008007_abnormal_cellular_replicative2.24223727
23MP0000490_abnormal_crypts_of2.21956695
24MP0001542_abnormal_bone_strength2.20408598
25MP0005464_abnormal_platelet_physiology2.16389426
26MP0009384_cardiac_valve_regurgitation2.05612174
27MP0002398_abnormal_bone_marrow2.03896174
28MP0010368_abnormal_lymphatic_system2.00006486
29MP0005174_abnormal_tail_pigmentation1.97287209
30MP0004957_abnormal_blastocyst_morpholog1.96416383
31MP0008058_abnormal_DNA_repair1.95283763
32MP0009379_abnormal_foot_pigmentation1.79767808
33MP0005075_abnormal_melanosome_morpholog1.76191689
34MP0002060_abnormal_skin_morphology1.75831961
35MP0002722_abnormal_immune_system1.75829663
36MP0005023_abnormal_wound_healing1.75242581
37MP0000767_abnormal_smooth_muscle1.74766953
38MP0000465_gastrointestinal_hemorrhage1.73000448
39MP0000689_abnormal_spleen_morphology1.69742627
40MP0001835_abnormal_antigen_presentation1.68392003
41MP0002095_abnormal_skin_pigmentation1.66894487
42MP0003091_abnormal_cell_migration1.65522317
43MP0002254_reproductive_system_inflammat1.62511037
44MP0003763_abnormal_thymus_physiology1.59659435
45MP0002295_abnormal_pulmonary_circulatio1.58543798
46MP0010307_abnormal_tumor_latency1.56458437
47MP0002429_abnormal_blood_cell1.56455729
48MP0008004_abnormal_stomach_pH1.55533838
49MP0005671_abnormal_response_to1.54879323
50MP0001533_abnormal_skeleton_physiology1.51838835
51MP0003191_abnormal_cellular_cholesterol1.51452078
52MP0000751_myopathy1.51361734
53MP0005508_abnormal_skeleton_morphology1.49900675
54MP0000013_abnormal_adipose_tissue1.45650914
55MP0002998_abnormal_bone_remodeling1.45032091
56MP0005390_skeleton_phenotype1.42580855
57MP0002132_abnormal_respiratory_system1.42306473
58MP0001849_ear_inflammation1.41832200
59MP0003303_peritoneal_inflammation1.40447018
60MP0005165_increased_susceptibility_to1.39620429
61MP0005623_abnormal_meninges_morphology1.39377914
62MP0000685_abnormal_immune_system1.36332199
63MP0001853_heart_inflammation1.35845835
64MP0000703_abnormal_thymus_morphology1.35552460
65MP0009785_altered_susceptibility_to1.34592197
66MP0003300_gastrointestinal_ulcer1.32904414
67MP0000716_abnormal_immune_system1.29598763
68MP0009333_abnormal_splenocyte_physiolog1.28157156
69MP0004510_myositis1.27555620
70MP0002166_altered_tumor_susceptibility1.27395260
71MP0002019_abnormal_tumor_incidence1.27319211
72MP0002420_abnormal_adaptive_immunity1.26935444
73MP0000313_abnormal_cell_death1.25970314
74MP0001819_abnormal_immune_cell1.24546934
75MP0003724_increased_susceptibility_to1.23748379
76MP0005025_abnormal_response_to1.23663643
77MP0005595_abnormal_vascular_smooth1.21390495
78MP0000350_abnormal_cell_proliferation1.20384787
79MP0002938_white_spotting1.20033255
80MP0002452_abnormal_antigen_presenting1.19096990
81MP0003567_abnormal_fetal_cardiomyocyte1.17678782
82MP0002896_abnormal_bone_mineralization1.15956939
83MP0003448_altered_tumor_morphology1.15431195
84MP0003075_altered_response_to1.14928933
85MP0002405_respiratory_system_inflammati1.13846383
86MP0003186_abnormal_redox_activity1.13244463
87MP0003172_abnormal_lysosome_physiology1.12056882
88MP0002108_abnormal_muscle_morphology1.11715715
89MP0001800_abnormal_humoral_immune1.11140646
90MP0009840_abnormal_foam_cell1.10946897
91MP0004858_abnormal_nervous_system1.10587561
92MP0005164_abnormal_response_to1.08828470
93MP0002933_joint_inflammation1.08810596
94MP0003943_abnormal_hepatobiliary_system1.07176607
95MP0002723_abnormal_immune_serum1.06698851
96MP0005000_abnormal_immune_tolerance1.05190565
97MP0000015_abnormal_ear_pigmentation1.04928975
98MP0002006_tumorigenesis1.04806242
99MP0006036_abnormal_mitochondrial_physio1.03310074
100MP0000858_altered_metastatic_potential1.02682169
101MP0003795_abnormal_bone_structure1.01583459
102MP0002148_abnormal_hypersensitivity_rea0.99998058
103MP0009931_abnormal_skin_appearance0.99372049
104MP0002419_abnormal_innate_immunity0.99106613
105MP0002009_preneoplasia0.98015074
106MP0008260_abnormal_autophagy0.97647898
107MP0010155_abnormal_intestine_physiology0.97600111
108MP0008932_abnormal_embryonic_tissue0.95488734
109MP0003453_abnormal_keratinocyte_physiol0.95380036
110MP0004947_skin_inflammation0.95235178
111MP0003436_decreased_susceptibility_to0.95120763
112MP0001348_abnormal_lacrimal_gland0.94926640
113MP0002796_impaired_skin_barrier0.93565585
114MP0003786_premature_aging0.93508201
115MP0000003_abnormal_adipose_tissue0.93231191
116MP0003950_abnormal_plasma_membrane0.92624395
117MP0002877_abnormal_melanocyte_morpholog0.92545947
118MP0006082_CNS_inflammation0.92343243
119MP0001873_stomach_inflammation0.92339518
120MP0005636_abnormal_mineral_homeostasis0.90210148
121MP0005451_abnormal_body_composition0.90048031
122MP0009278_abnormal_bone_marrow0.88862138
123MP0000343_altered_response_to0.87542569
124MP0010352_gastrointestinal_tract_polyps0.85642697
125MP0000249_abnormal_blood_vessel0.85556595
126MP0010030_abnormal_orbit_morphology0.84433023
127MP0001879_abnormal_lymphatic_vessel0.82633552
128MP0002080_prenatal_lethality0.82099283
129MP0001293_anophthalmia0.82050265
130MP0003866_abnormal_defecation0.81507349
131MP0005076_abnormal_cell_differentiation0.78707358
132MP0009764_decreased_sensitivity_to0.78073701
133MP0008877_abnormal_DNA_methylation0.77421049
134MP0001730_embryonic_growth_arrest0.77040064
135MP0003566_abnormal_cell_adhesion0.75080911
136MP0001614_abnormal_blood_vessel0.75046299
137MP0001764_abnormal_homeostasis0.74377746
138MP0002128_abnormal_blood_circulation0.74124449
139MP0002113_abnormal_skeleton_development0.73574157
140MP0005083_abnormal_biliary_tract0.72245791
141MP0001845_abnormal_inflammatory_respons0.71878050
142MP0003828_pulmonary_edema0.69386107
143MP0001243_abnormal_dermal_layer0.69335858
144MP0001697_abnormal_embryo_size0.67341215
145MP0002086_abnormal_extraembryonic_tissu0.66254436
146MP0004233_abnormal_muscle_weight0.66057083
147MP0005388_respiratory_system_phenotype0.65985014
148MP0002133_abnormal_respiratory_system0.65985014
149MP0008469_abnormal_protein_level0.65837023
150MP0005166_decreased_susceptibility_to0.65464443
151MP0009250_abnormal_appendicular_skeleto0.65350757
152MP0000598_abnormal_liver_morphology0.65262821
153MP0003123_paternal_imprinting0.64685867
154MP0005501_abnormal_skin_physiology0.64457152
155MP0005670_abnormal_white_adipose0.63220884
156MP0003941_abnormal_skin_development0.62938662
157MP0000759_abnormal_skeletal_muscle0.62700238
158MP0000733_abnormal_muscle_development0.62386935
159MP0001851_eye_inflammation0.61661319
160MP0002075_abnormal_coat/hair_pigmentati0.61042129
161MP0000163_abnormal_cartilage_morphology0.60893955
162MP0001191_abnormal_skin_condition0.60223563
163MP0009765_abnormal_xenobiotic_induced0.59986872
164MP0000681_abnormal_thyroid_gland0.59599548
165MP0005375_adipose_tissue_phenotype0.58838849
166MP0005621_abnormal_cell_physiology0.58792020
167MP0005171_absent_coat_pigmentation0.58104635
168MP0008770_decreased_survivor_rate0.58025853
169MP0001915_intracranial_hemorrhage0.57030481
170MP0003984_embryonic_growth_retardation0.56789835
171MP0000477_abnormal_intestine_morphology0.56572073
172MP0002088_abnormal_embryonic_growth/wei0.54027388
173MP0004197_abnormal_fetal_growth/weight/0.53665977

Predicted human phenotypes

RankGene SetZ-score
1Abnormal number of erythroid precursors (HP:0012131)7.22990228
2Premature rupture of membranes (HP:0001788)7.08484032
3Abnormality of cells of the erythroid lineage (HP:0012130)7.02160300
4Poikilocytosis (HP:0004447)6.72338405
5Protrusio acetabuli (HP:0003179)6.56095523
6Petechiae (HP:0000967)5.09290601
7Acanthocytosis (HP:0001927)4.80893084
8Aplastic anemia (HP:0001915)4.50672790
9Prolonged bleeding time (HP:0003010)4.46276934
10Aortic dissection (HP:0002647)4.29306078
11Aortic aneurysm (HP:0004942)4.21653750
12Reticulocytopenia (HP:0001896)4.14032349
13Ankle contracture (HP:0006466)4.04233198
14Abnormality of reticulocytes (HP:0004312)4.03906515
15Reticulocytosis (HP:0001923)3.98210733
16Vertebral compression fractures (HP:0002953)3.81235473
17Pallor (HP:0000980)3.73968835
18Type 1 muscle fiber predominance (HP:0003803)3.63070789
19Microcytic anemia (HP:0001935)3.59757762
20Soft skin (HP:0000977)3.58115926
21Fragile skin (HP:0001030)3.56372914
22Bladder diverticulum (HP:0000015)3.55999832
23Atrophic scars (HP:0001075)3.54264300
24Chronic otitis media (HP:0000389)3.50631050
25Follicular hyperkeratosis (HP:0007502)3.44646433
26Spinal rigidity (HP:0003306)3.40862594
27Cervical subluxation (HP:0003308)3.40788886
28Vascular tortuosity (HP:0004948)3.38317964
29Thrombocytosis (HP:0001894)3.38224529
30Peritonitis (HP:0002586)3.37396016
31Macrocytic anemia (HP:0001972)3.28651187
32Abnormality of dentin (HP:0010299)3.26914055
33Diaphragmatic weakness (HP:0009113)3.23667187
34Wormian bones (HP:0002645)3.23549779
35Dilatation of the ascending aorta (HP:0005111)3.23088500
36Hypochromic microcytic anemia (HP:0004840)3.21995759
37Genu recurvatum (HP:0002816)3.13062279
38Hyperbilirubinemia (HP:0002904)3.11812154
39Blue sclerae (HP:0000592)3.08601804
40Short middle phalanx of the 5th finger (HP:0004220)3.06812565
41Spondylolisthesis (HP:0003302)3.06098952
42Hypochromic anemia (HP:0001931)3.05973987
43Epistaxis (HP:0000421)3.01778776
4411 pairs of ribs (HP:0000878)2.98745855
45Increased connective tissue (HP:0009025)2.97703594
46Increased variability in muscle fiber diameter (HP:0003557)2.96929472
47Slender build (HP:0001533)2.86327289
48Osteolytic defects of the hand bones (HP:0009699)2.83356449
49Osteolytic defects of the phalanges of the hand (HP:0009771)2.83356449
50Broad metatarsal (HP:0001783)2.81273709
51Abnormality of skeletal muscle fiber size (HP:0012084)2.80232404
52Increased serum ferritin (HP:0003281)2.80094844
53Arterial tortuosity (HP:0005116)2.77220718
54Joint stiffness (HP:0001387)2.76679460
55Birth length less than 3rd percentile (HP:0003561)2.73788709
56IgM deficiency (HP:0002850)2.70627766
57Neonatal short-limb short stature (HP:0008921)2.70061970
58Myelodysplasia (HP:0002863)2.66240515
59Cerebral aneurysm (HP:0004944)2.64659924
60Elbow flexion contracture (HP:0002987)2.62503921
61Dysostosis multiplex (HP:0000943)2.62293676
62Mildly elevated creatine phosphokinase (HP:0008180)2.60738592
63Biconcave vertebral bodies (HP:0004586)2.58960762
64Purpura (HP:0000979)2.58924758
65Abnormality of the acetabulum (HP:0003170)2.57672268
66Aortic regurgitation (HP:0001659)2.57527967
67Paralysis (HP:0003470)2.57445539
68Cutaneous photosensitivity (HP:0000992)2.56429171
69Impaired platelet aggregation (HP:0003540)2.55934185
70Abnormal platelet function (HP:0011869)2.55934185
71Joint laxity (HP:0001388)2.49356763
72Bowel diverticulosis (HP:0005222)2.43765325
73Type I transferrin isoform profile (HP:0003642)2.41876498
74Abnormality of glycolipid metabolism (HP:0010969)2.41618112
75Abnormality of liposaccharide metabolism (HP:0010968)2.41618112
76Abnormality of glycosphingolipid metabolism (HP:0004343)2.41618112
77Shallow orbits (HP:0000586)2.39481051
78Distal lower limb muscle weakness (HP:0009053)2.38174131
79Cholelithiasis (HP:0001081)2.36793272
80Mitral valve prolapse (HP:0001634)2.36406617
81Mitral regurgitation (HP:0001653)2.34014005
82Aneurysm (HP:0002617)2.30837023
83Reduced antithrombin III activity (HP:0001976)2.30650513
84Aplasia/Hypoplasia of the sacrum (HP:0008517)2.30426782
85Pustule (HP:0200039)2.29279639
86Acute lymphatic leukemia (HP:0006721)2.29003658
87Nonimmune hydrops fetalis (HP:0001790)2.28415084
88Type 2 muscle fiber atrophy (HP:0003554)2.25982518
89Abnormality of iron homeostasis (HP:0011031)2.25845481
90Abnormal delivery (HP:0001787)2.25221514
91Generalized amyotrophy (HP:0003700)2.21157723
92Muscle fiber atrophy (HP:0100295)2.19502312
93Round ear (HP:0100830)2.19343276
94Lymphoma (HP:0002665)2.18957405
95Persistence of primary teeth (HP:0006335)2.17967281
96Distal lower limb amyotrophy (HP:0008944)2.17824935
97Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.17354578
98Abnormal platelet volume (HP:0011876)2.16668853
99Aortic valve stenosis (HP:0001650)2.16588650
100Achilles tendon contracture (HP:0001771)2.16211037
101Abnormality of mucopolysaccharide metabolism (HP:0011020)2.15184478
102Abnormality of polysaccharide metabolism (HP:0011012)2.15184478
103Abnormality of glycosaminoglycan metabolism (HP:0004371)2.15184478
104Mucopolysacchariduria (HP:0008155)2.14740073
105Urinary glycosaminoglycan excretion (HP:0003541)2.14740073
106Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.14652242
107Overgrowth (HP:0001548)2.12860721
108Acute myeloid leukemia (HP:0004808)2.12379747
109Spontaneous hematomas (HP:0007420)2.07770825
110Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.07430574
111Asymmetric septal hypertrophy (HP:0001670)2.05995350
112Cardiovascular calcification (HP:0011915)2.05025709
113Hyperextensible skin (HP:0000974)2.04953586
114Emphysema (HP:0002097)2.04538039
115Upper limb amyotrophy (HP:0009129)2.01867551
116Distal upper limb amyotrophy (HP:0007149)2.01867551
117Abnormality of transition element cation homeostasis (HP:0011030)2.01352060
118Increased neuronal autofluorescent lipopigment (HP:0002074)2.00987662
119Abnormality of the heme biosynthetic pathway (HP:0010472)10.2145430
120Oral leukoplakia (HP:0002745)1.99565517
121Amaurosis fugax (HP:0100576)1.98962838
122Microvesicular hepatic steatosis (HP:0001414)1.98648232
123Abnormality of the phalanges of the 5th finger (HP:0004213)1.97779454
124Menorrhagia (HP:0000132)1.97218147
125Abnormality of the Achilles tendon (HP:0005109)1.96249770
126Cutaneous melanoma (HP:0012056)1.94880050
127Abnormal gallbladder morphology (HP:0012437)1.94732959
128Abnormality of the columella (HP:0009929)1.92329706
129Mitral stenosis (HP:0001718)1.92125339
130Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.92039792
131Hyperacusis (HP:0010780)1.90665166
132Basal cell carcinoma (HP:0002671)1.89922394
133Abnormality of the preputium (HP:0100587)1.86846429
134Systemic lupus erythematosus (HP:0002725)1.86587158
135Trismus (HP:0000211)1.86018705
136Conjunctival telangiectasia (HP:0000524)1.85259077
137Ovoid vertebral bodies (HP:0003300)1.85239014
138Delayed closure of the anterior fontanelle (HP:0001476)1.84540799
139Gingival bleeding (HP:0000225)1.84347890
140Increased mean platelet volume (HP:0011877)1.83714134
141Hypoventilation (HP:0002791)1.83638059
142Ectopia lentis (HP:0001083)1.83524598
143Albinism (HP:0001022)1.83266859
144Bruising susceptibility (HP:0000978)1.82939887
145Insomnia (HP:0100785)1.81936763
146Osteomalacia (HP:0002749)1.81889121
147Spinal cord lesions (HP:0100561)1.81803367
148Syringomyelia (HP:0003396)1.81803367
149Broad face (HP:0000283)1.81756765
150Abnormality of chromosome stability (HP:0003220)1.81487125
151Papilledema (HP:0001085)1.81018341
152Nausea (HP:0002018)1.80635574
153Broad palm (HP:0001169)1.80534366
154Chromsome breakage (HP:0040012)1.79447300
155Short nail (HP:0001799)1.79152020
156Thin bony cortex (HP:0002753)1.79009574
157Small intestinal stenosis (HP:0012848)1.78999116
158Duodenal stenosis (HP:0100867)1.78999116
159Natal tooth (HP:0000695)1.78515454
160Wrist flexion contracture (HP:0001239)1.78405379
161Meckel diverticulum (HP:0002245)1.78385618
162Bone marrow hypocellularity (HP:0005528)1.78364096
163Abnormality of the vasculature of the conjunctiva (HP:0008054)1.78097799
164Decreased activity of mitochondrial respiratory chain (HP:0008972)1.76274138
165Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.76274138
166Ulnar deviation of the wrist (HP:0003049)1.75497813
167Recurrent viral infections (HP:0004429)1.74915040
168Myocardial infarction (HP:0001658)1.74798348
169Colon cancer (HP:0003003)1.74012395
170Short 4th metacarpal (HP:0010044)1.74011902
171Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.74011902
172Abnormal glycosylation (HP:0012345)1.73610856
173Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.73610856
174Abnormal protein N-linked glycosylation (HP:0012347)1.73610856
175Abnormal protein glycosylation (HP:0012346)1.73610856
176Pancytopenia (HP:0001876)1.73450369
177Abnormality of the ileum (HP:0001549)1.73286552
178Abnormality of the prostate (HP:0008775)1.72648982
179Nasal polyposis (HP:0100582)1.72080005
180Abnormal spermatogenesis (HP:0008669)1.70811249
181Urticaria (HP:0001025)1.70220648
182Polycythemia (HP:0001901)1.69885792
183Abnormality of the anterior horn cell (HP:0006802)1.65441097
184Degeneration of anterior horn cells (HP:0002398)1.65441097
185Patchy hypopigmentation of hair (HP:0011365)1.64722445
186Recurrent bronchitis (HP:0002837)1.64382521
187Recurrent abscess formation (HP:0002722)1.63819832
188Abnormality of the nasal mucosa (HP:0000433)1.63085826
189Erythema (HP:0010783)1.62935052

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN14.29094895
2EIF2AK13.84029254
3MYLK3.68622275
4TESK13.41476459
5PIM23.25313713
6NME23.15402245
7CDC73.12299778
8DDR22.99102652
9FLT32.63449957
10WEE12.47475606
11PDGFRA2.45119958
12EEF2K2.41953405
13VRK12.34520159
14TLK12.21029861
15KIT2.20225866
16ACVR1B2.12757885
17MAP4K12.11307595
18TTN2.04620480
19PIM11.99096797
20TGFBR11.98983506
21RIPK11.98866026
22BUB11.92490197
23STK41.89061395
24PRPF4B1.87493923
25RPS6KB21.86512094
26STK161.85655627
27CCNB11.84107784
28BRSK21.83139157
29NEK91.83088753
30DYRK31.76547196
31PIK3CG1.74116603
32TAOK21.68405063
33BMX1.67664907
34CDC42BPA1.67528127
35MAP2K31.67236691
36TRIB31.63486921
37PAK41.63241734
38MST1R1.60791472
39ABL21.60168237
40JAK31.59689762
41PTK21.55088390
42NEK21.53990096
43SIK11.46508866
44SCYL21.46399468
45TESK21.44048672
46TAOK31.43133636
47BTK1.42639012
48EPHB21.42052414
49EPHA21.39986563
50BRSK11.38497914
51TEC1.35285711
52MKNK11.28176669
53MAP3K61.28005781
54ZAK1.27998210
55CLK11.23194089
56PASK1.20725094
57KDR1.17851403
58MAPKAPK51.17734950
59STK381.16429786
60SYK1.14396609
61MAPKAPK31.13691132
62PRKD21.13628299
63LATS21.13230845
64IRAK31.12937147
65AURKB1.12639039
66ATR1.12502264
67DAPK31.12450364
68RAF11.08719254
69EPHB11.08246227
70ZAP701.08243611
71CDK71.07888374
72TXK1.07167786
73SMG11.06837499
74CDK191.06520700
75LIMK11.05873262
76STK101.03678732
77PRKG21.02297479
78ILK1.01766702
79TYK20.98240157
80RPS6KA40.97525148
81MOS0.97199401
82MET0.95974261
83RPS6KA20.95859556
84SRPK10.94756306
85IRAK40.94264137
86LATS10.93362600
87IKBKE0.93175021
88TRPM70.90666581
89NTRK10.89640518
90PTK2B0.88871101
91TBK10.88477657
92MAPK110.87713736
93IKBKB0.86966207
94MAPK70.86147040
95PDGFRB0.85757486
96FES0.81141082
97CDK80.81104719
98MAP3K80.80424649
99BLK0.79304607
100LYN0.78964927
101PLK10.76371561
102NEK10.76341604
103MATK0.75700820
104CSF1R0.75489714
105LMTK20.75300111
106RPS6KA60.73854274
107MAP3K10.73729758
108GRK70.72645586
109CDK40.71842336
110PAK10.71086360
111TGFBR20.70375352
112MAP3K140.70059414
113TIE10.70009577
114PKN20.68630092
115LRRK20.68164310
116JAK10.67286606
117BCKDK0.65294066
118DMPK0.64492660
119STK30.63981954
120RPS6KL10.63117932
121RPS6KC10.63117932
122GRK60.63005285
123PDPK10.62520172
124MAP3K110.61834184
125NUAK10.60309689
126ROCK10.60161056
127TSSK60.58900204
128RPS6KA50.58669507
129MAP3K30.57534517
130MKNK20.56895365
131EIF2AK20.56372370
132CDK60.55936007
133CSK0.55848188
134ATM0.55383329
135EIF2AK30.55162992
136CHEK20.54742051
137PRKD30.53148578
138MUSK0.52964894
139TTK0.52868962
140MTOR0.51022266
141FGFR40.50700825
142CHEK10.49403847
143LCK0.49114711
144PAK20.47767459
145MAP3K70.46449018
146ARAF0.45227731
147GSK3A0.44322928
148CSNK2A10.44079018
149CDK90.43224327
150PLK30.42962650
151JAK20.42560489
152GRK50.42086170
153ADRBK10.40804572
154CAMKK20.40535206
155TNIK0.40181306
156BMPR1B0.39839198
157MAPKAPK20.39790688
158PTK60.39683165
159MAP2K10.39643134
160HCK0.39444386
161ROCK20.39356086
162PRKD10.39341383
163MARK20.39322955
164TNK20.38376301
165MELK0.38322392
166AURKA0.37942997
167MAP3K130.37177490
168MAPK40.37046362
169HIPK20.36779587
170TAOK10.34553150
171MAPK120.34030633

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.38343152
2Ribosome_Homo sapiens_hsa030104.56998104
3Mismatch repair_Homo sapiens_hsa034303.84755541
4Glycosaminoglycan degradation_Homo sapiens_hsa005313.47718796
5Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008603.47061039
6ECM-receptor interaction_Homo sapiens_hsa045123.29445006
7Base excision repair_Homo sapiens_hsa034103.00645780
8Homologous recombination_Homo sapiens_hsa034402.74364454
9Spliceosome_Homo sapiens_hsa030402.48769372
10Cell cycle_Homo sapiens_hsa041102.41038825
11Nucleotide excision repair_Homo sapiens_hsa034202.40400410
12Focal adhesion_Homo sapiens_hsa045102.35013981
13Pyrimidine metabolism_Homo sapiens_hsa002402.20974506
14Systemic lupus erythematosus_Homo sapiens_hsa053222.17054322
15Non-homologous end-joining_Homo sapiens_hsa034502.14643166
16Protein digestion and absorption_Homo sapiens_hsa049741.99638244
17Amoebiasis_Homo sapiens_hsa051461.96244460
18Lysosome_Homo sapiens_hsa041421.94718738
19Proteasome_Homo sapiens_hsa030501.93893431
20RNA polymerase_Homo sapiens_hsa030201.92442655
21Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.90922750
22Fanconi anemia pathway_Homo sapiens_hsa034601.77351679
23RNA transport_Homo sapiens_hsa030131.77222550
24p53 signaling pathway_Homo sapiens_hsa041151.71242188
25Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.70496354
26Sulfur relay system_Homo sapiens_hsa041221.57578757
27Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.56310060
28One carbon pool by folate_Homo sapiens_hsa006701.53799622
29RNA degradation_Homo sapiens_hsa030181.49678482
30AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.47862698
31Hematopoietic cell lineage_Homo sapiens_hsa046401.46751392
32Sulfur metabolism_Homo sapiens_hsa009201.45232811
33Leukocyte transendothelial migration_Homo sapiens_hsa046701.44875633
34Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.44184963
35Herpes simplex infection_Homo sapiens_hsa051681.43573417
36Proteoglycans in cancer_Homo sapiens_hsa052051.36772879
37Regulation of actin cytoskeleton_Homo sapiens_hsa048101.33078275
38Renin-angiotensin system_Homo sapiens_hsa046141.32093458
39Phagosome_Homo sapiens_hsa041451.25349089
40TNF signaling pathway_Homo sapiens_hsa046681.21288324
41Purine metabolism_Homo sapiens_hsa002301.19855712
42Viral myocarditis_Homo sapiens_hsa054161.18378707
43Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.18162790
44Measles_Homo sapiens_hsa051621.12208019
45Transcriptional misregulation in cancer_Homo sapiens_hsa052021.10944777
46Folate biosynthesis_Homo sapiens_hsa007901.08340388
47Thyroid cancer_Homo sapiens_hsa052161.07380831
48Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.06591871
49Vitamin B6 metabolism_Homo sapiens_hsa007501.06362397
50Staphylococcus aureus infection_Homo sapiens_hsa051501.05624838
51Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.05268075
52Endocytosis_Homo sapiens_hsa041441.05045303
53Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.04454586
54Leishmaniasis_Homo sapiens_hsa051401.03711745
55Viral carcinogenesis_Homo sapiens_hsa052031.03140063
56Basal transcription factors_Homo sapiens_hsa030221.02731782
57Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.99749110
58Alcoholism_Homo sapiens_hsa050340.98700560
59Salmonella infection_Homo sapiens_hsa051320.98119830
60mRNA surveillance pathway_Homo sapiens_hsa030150.94673255
61Antigen processing and presentation_Homo sapiens_hsa046120.94343116
62Dilated cardiomyopathy_Homo sapiens_hsa054140.93778003
63Protein export_Homo sapiens_hsa030600.92080402
64PI3K-Akt signaling pathway_Homo sapiens_hsa041510.91775262
65Primary immunodeficiency_Homo sapiens_hsa053400.91651835
66Tuberculosis_Homo sapiens_hsa051520.90657305
67Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.90561455
68Apoptosis_Homo sapiens_hsa042100.89955644
69Rheumatoid arthritis_Homo sapiens_hsa053230.85742962
70Legionellosis_Homo sapiens_hsa051340.83565342
71Acute myeloid leukemia_Homo sapiens_hsa052210.83440159
72Malaria_Homo sapiens_hsa051440.82938363
73Chronic myeloid leukemia_Homo sapiens_hsa052200.82839113
74Epstein-Barr virus infection_Homo sapiens_hsa051690.82829067
75Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.82798151
76Adherens junction_Homo sapiens_hsa045200.81819937
77Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.80899779
78Platelet activation_Homo sapiens_hsa046110.80756935
79RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.79604059
80Hepatitis B_Homo sapiens_hsa051610.79579818
81Asthma_Homo sapiens_hsa053100.78012753
82Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.76869419
83N-Glycan biosynthesis_Homo sapiens_hsa005100.75725026
84Hepatitis C_Homo sapiens_hsa051600.75711154
85Pentose phosphate pathway_Homo sapiens_hsa000300.75621854
86Graft-versus-host disease_Homo sapiens_hsa053320.74581309
87Small cell lung cancer_Homo sapiens_hsa052220.74519452
88Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.73696336
89Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.73614873
90Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.71879526
91Pathways in cancer_Homo sapiens_hsa052000.69072102
92Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.68997811
93Autoimmune thyroid disease_Homo sapiens_hsa053200.68596952
94HTLV-I infection_Homo sapiens_hsa051660.68402993
95Sphingolipid metabolism_Homo sapiens_hsa006000.68331085
96Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.68226348
97Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.66185724
98Phospholipase D signaling pathway_Homo sapiens_hsa040720.64945159
99Jak-STAT signaling pathway_Homo sapiens_hsa046300.63470256
100NF-kappa B signaling pathway_Homo sapiens_hsa040640.61845330
101Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.61610962
102Complement and coagulation cascades_Homo sapiens_hsa046100.60175389
103Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.59221572
104Vibrio cholerae infection_Homo sapiens_hsa051100.57996063
105Adipocytokine signaling pathway_Homo sapiens_hsa049200.57950559
106B cell receptor signaling pathway_Homo sapiens_hsa046620.57645099
107Vascular smooth muscle contraction_Homo sapiens_hsa042700.57561691
108Non-small cell lung cancer_Homo sapiens_hsa052230.57481898
109Influenza A_Homo sapiens_hsa051640.56259828
110Rap1 signaling pathway_Homo sapiens_hsa040150.52769540
111Selenocompound metabolism_Homo sapiens_hsa004500.52651867
112Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.52516593
113SNARE interactions in vesicular transport_Homo sapiens_hsa041300.52248956
114Melanoma_Homo sapiens_hsa052180.51863098
115Bladder cancer_Homo sapiens_hsa052190.51229218
116Intestinal immune network for IgA production_Homo sapiens_hsa046720.50755246
117Prostate cancer_Homo sapiens_hsa052150.50574220
118African trypanosomiasis_Homo sapiens_hsa051430.49948445
119Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.49386211
120Shigellosis_Homo sapiens_hsa051310.49346094
121Toxoplasmosis_Homo sapiens_hsa051450.48110486
122Prion diseases_Homo sapiens_hsa050200.47928349
123Gap junction_Homo sapiens_hsa045400.47449691
124Toll-like receptor signaling pathway_Homo sapiens_hsa046200.44902381
125Fructose and mannose metabolism_Homo sapiens_hsa000510.44651450
126Chemokine signaling pathway_Homo sapiens_hsa040620.43200112
127Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.42924357
128Cyanoamino acid metabolism_Homo sapiens_hsa004600.42081487
129Drug metabolism - other enzymes_Homo sapiens_hsa009830.41288818
130Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.40943773
131MicroRNAs in cancer_Homo sapiens_hsa052060.40138323
132Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.39897811
133ABC transporters_Homo sapiens_hsa020100.39197477
134Pertussis_Homo sapiens_hsa051330.39172565
135Cysteine and methionine metabolism_Homo sapiens_hsa002700.35125830
136Pancreatic cancer_Homo sapiens_hsa052120.35066423
137Oocyte meiosis_Homo sapiens_hsa041140.33578269
138Glutathione metabolism_Homo sapiens_hsa004800.33419300
139Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.33179078
140Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.31245541
141Osteoclast differentiation_Homo sapiens_hsa043800.31122157
142Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.31104148
143NOD-like receptor signaling pathway_Homo sapiens_hsa046210.27875786
144Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.27757115
145Parkinsons disease_Homo sapiens_hsa050120.26503212
146Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.25888911
147Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.25414667
148Arachidonic acid metabolism_Homo sapiens_hsa005900.25021435
149Allograft rejection_Homo sapiens_hsa053300.24634310
150Notch signaling pathway_Homo sapiens_hsa043300.24436456
151Galactose metabolism_Homo sapiens_hsa000520.22461173
152Other glycan degradation_Homo sapiens_hsa005110.21508235
153Central carbon metabolism in cancer_Homo sapiens_hsa052300.21116219
154Huntingtons disease_Homo sapiens_hsa050160.19020695

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