ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	6.03180657
2	response to pheromone (GO:0019236)	4.98176319
3	L-fucose metabolic process (GO:0042354)	4.81522655
4	L-fucose catabolic process (GO:0042355)	4.81522655
5	fucose catabolic process (GO:0019317)	4.81522655
6	sulfation (GO:0051923)	4.12751289
7	indolalkylamine metabolic process (GO:0006586)	3.93044824
8	kynurenine metabolic process (GO:0070189)	3.85895067
9	tryptophan catabolic process (GO:0006569)	3.79097309
10	indole-containing compound catabolic process (GO:0042436)	3.79097309
11	indolalkylamine catabolic process (GO:0046218)	3.79097309
12	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.77114722
13	gamma-aminobutyric acid transport (GO:0015812)	3.77013125
14	serotonin metabolic process (GO:0042428)	3.74009874
15	nephron epithelium morphogenesis (GO:0072088)	3.65828601
16	nephron tubule morphogenesis (GO:0072078)	3.65828601
17	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.65334300
18	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.65334300
19	NADH dehydrogenase complex assembly (GO:0010257)	3.65334300
20	tryptophan metabolic process (GO:0006568)	3.63867413
21	indole-containing compound metabolic process (GO:0042430)	3.44774151
22	regulation of gene silencing by RNA (GO:0060966)	3.44326109
23	regulation of posttranscriptional gene silencing (GO:0060147)	3.44326109
24	regulation of gene silencing by miRNA (GO:0060964)	3.44326109
25	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.42550823
26	regulation of hippo signaling (GO:0035330)	3.42041302
27	protein complex biogenesis (GO:0070271)	3.40334826
28	primary amino compound metabolic process (GO:1901160)	3.34813294
29	ATP synthesis coupled proton transport (GO:0015986)	3.27777410
30	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.27777410
31	spinal cord motor neuron differentiation (GO:0021522)	3.19850824
32	mitochondrial respiratory chain complex assembly (GO:0033108)	3.13973922
33	water-soluble vitamin biosynthetic process (GO:0042364)	3.13913056
34	nonmotile primary cilium assembly (GO:0035058)	3.10709425
35	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.05411372
36	otic vesicle formation (GO:0030916)	3.04409178
37	neuronal action potential (GO:0019228)	3.02672956
38	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.95736414
39	negative regulation of systemic arterial blood pressure (GO:0003085)	2.94354465
40	presynaptic membrane assembly (GO:0097105)	2.84471298
41	cell proliferation in forebrain (GO:0021846)	2.82099516
42	cellular ketone body metabolic process (GO:0046950)	2.80611067
43	cAMP catabolic process (GO:0006198)	2.80103495
44	kidney morphogenesis (GO:0060993)	2.79441011
45	purine ribonucleoside bisphosphate metabolic process (GO:0034035)	2.74782353
46	3-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)	2.74782353
47	neuron fate determination (GO:0048664)	2.74601838
48	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.73150192
49	regulation of translation, ncRNA-mediated (GO:0045974)	2.73150192
50	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.73150192
51	behavioral response to ethanol (GO:0048149)	2.72992129
52	regulation of histone phosphorylation (GO:0033127)	2.70922076
53	renal tubule morphogenesis (GO:0061333)	2.70486409
54	detection of light stimulus involved in visual perception (GO:0050908)	2.68421784
55	detection of light stimulus involved in sensory perception (GO:0050962)	2.68421784
56	negative regulation of telomere maintenance (GO:0032205)	2.67114713
57	somite development (GO:0061053)	2.66700273
58	neuronal stem cell maintenance (GO:0097150)	2.66122147
59	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.64601086
60	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.64293474
61	negative regulation of mesenchymal cell apoptotic process (GO:2001054)	2.63450344
62	mitochondrion morphogenesis (GO:0070584)	2.62324952
63	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.60994950
64	NAD biosynthetic process (GO:0009435)	2.60591575
65	DNA deamination (GO:0045006)	2.58523503
66	electron transport chain (GO:0022900)	2.57818825
67	epithelial cilium movement (GO:0003351)	2.54568845
68	intracellular protein transmembrane import (GO:0044743)	2.54506425
69	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.53293278
70	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.53189165
71	limb bud formation (GO:0060174)	2.52819201
72	protein import into peroxisome matrix (GO:0016558)	2.52103827
73	positive regulation of cAMP-mediated signaling (GO:0043950)	2.51684787
74	negative regulation of astrocyte differentiation (GO:0048712)	2.51476347
75	ketone body metabolic process (GO:1902224)	2.50469230
76	startle response (GO:0001964)	2.49707130
77	hindbrain development (GO:0030902)	2.47834713
78	ubiquinone biosynthetic process (GO:0006744)	2.47392021
79	positive regulation of fatty acid oxidation (GO:0046321)	2.47280269
80	platelet dense granule organization (GO:0060155)	2.46927986
81	transmission of nerve impulse (GO:0019226)	2.46244242
82	respiratory electron transport chain (GO:0022904)	2.45426681
83	histone-serine phosphorylation (GO:0035404)	2.44867886
84	cornea development in camera-type eye (GO:0061303)	2.43744476
85	fucosylation (GO:0036065)	2.43566570
86	respiratory chain complex IV assembly (GO:0008535)	2.43359051
87	cyclic nucleotide catabolic process (GO:0009214)	2.43235062
88	thalamus development (GO:0021794)	2.42811194
89	synapsis (GO:0007129)	2.42477073
90	regulation of mesenchymal cell apoptotic process (GO:2001053)	2.41634175
91	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.41231165
92	photoreceptor cell development (GO:0042461)	2.41170420
93	regulation of mesoderm development (GO:2000380)	2.40578598
94	neuromuscular synaptic transmission (GO:0007274)	2.40457713
95	cilium organization (GO:0044782)	2.39789512
96	pyrimidine nucleobase catabolic process (GO:0006208)	2.39632560
97	peristalsis (GO:0030432)	2.39622002
98	signal peptide processing (GO:0006465)	2.38826669
99	male meiosis I (GO:0007141)	2.38713386
100	neural tube formation (GO:0001841)	2.38708446

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	4.03221139
2	EZH2_22144423_ChIP-Seq_EOC_Human	4.01547393
3	VDR_22108803_ChIP-Seq_LS180_Human	3.16414481
4	GBX2_23144817_ChIP-Seq_PC3_Human	2.90832614
5	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.70923753
6	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.63547893
7	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.51200038
8	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.42438279
9	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.42295060
10	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.39891303
11	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.23284779
12	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.19988402
13	EWS_26573619_Chip-Seq_HEK293_Human	2.13219026
14	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.08442272
15	FUS_26573619_Chip-Seq_HEK293_Human	2.05024070
16	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.02401076
17	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.92610431
18	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.89862807
19	P300_19829295_ChIP-Seq_ESCs_Human	1.79491170
20	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.78354881
21	ER_23166858_ChIP-Seq_MCF-7_Human	1.78218457
22	TAF15_26573619_Chip-Seq_HEK293_Human	1.75240198
23	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.70961703
24	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.68102149
25	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.66738356
26	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.59712018
27	MYC_18940864_ChIP-ChIP_HL60_Human	1.58889021
28	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.57440926
29	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.56960966
30	REST_21632747_ChIP-Seq_MESCs_Mouse	1.54030973
31	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.51486959
32	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.50831869
33	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.50087626
34	BCAT_22108803_ChIP-Seq_LS180_Human	1.48137236
35	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.47945232
36	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.47897265
37	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.46154045
38	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.46027137
39	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.45386361
40	AR_25329375_ChIP-Seq_VCAP_Human	1.44121299
41	AR_21572438_ChIP-Seq_LNCaP_Human	1.42883710
42	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.42729110
43	IGF1R_20145208_ChIP-Seq_DFB_Human	1.41666655
44	RNF2_27304074_Chip-Seq_NSC_Mouse	1.40085509
45	STAT3_23295773_ChIP-Seq_U87_Human	1.36419345
46	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.35825169
47	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.34503853
48	IRF1_19129219_ChIP-ChIP_H3396_Human	1.34154634
49	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.33844707
50	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.33743239
51	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.32221623
52	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.32221623
53	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.32034985
54	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.31856055
55	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.31851060
56	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.31851060
57	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.30073460
58	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.29355661
59	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.28551115
60	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.28068107
61	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.26545560
62	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.26385995
63	TP53_22573176_ChIP-Seq_HFKS_Human	1.26363363
64	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.22567750
65	SMAD4_21799915_ChIP-Seq_A2780_Human	1.22157852
66	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.21801776
67	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.21612525
68	TP53_16413492_ChIP-PET_HCT116_Human	1.19546557
69	TCF4_23295773_ChIP-Seq_U87_Human	1.18554360
70	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.17930949
71	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.17685823
72	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.16938919
73	CBP_20019798_ChIP-Seq_JUKART_Human	1.16262908
74	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.16262908
75	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.13005582
76	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.12018544
77	NANOG_19829295_ChIP-Seq_ESCs_Human	1.11798057
78	SOX2_19829295_ChIP-Seq_ESCs_Human	1.11798057
79	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.11112357
80	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.08988386
81	RUNX2_22187159_ChIP-Seq_PCA_Human	1.07562794
82	TCF4_22108803_ChIP-Seq_LS180_Human	1.06881786
83	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.05536230
84	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.05014531
85	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.04954352
86	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.03852135
87	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.02564625
88	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.00917248
89	HOXB7_26014856_ChIP-Seq_BT474_Human	1.00679944
90	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.00637720
91	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.99903296
92	DROSHA_22980978_ChIP-Seq_HELA_Human	0.99849394
93	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	0.99307494
94	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	0.99281880
95	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.99197311
96	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	0.98855448
97	NCOR_22424771_ChIP-Seq_293T_Human	0.98543821
98	EZH2_18974828_ChIP-Seq_MESCs_Mouse	0.98117904
99	RNF2_18974828_ChIP-Seq_MESCs_Mouse	0.98117904
100	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	0.97928398

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003136_yellow_coat_color	3.61527591
2	MP0002653_abnormal_ependyma_morphology	2.73029317
3	MP0000569_abnormal_digit_pigmentation	2.51143128
4	MP0005551_abnormal_eye_electrophysiolog	2.32004477
5	MP0009379_abnormal_foot_pigmentation	2.27488780
6	MP0001485_abnormal_pinna_reflex	2.25651084
7	MP0001968_abnormal_touch/_nociception	2.22364284
8	MP0004885_abnormal_endolymph	2.22019557
9	MP0003195_calcinosis	2.11292182
10	MP0002938_white_spotting	2.11129540
11	MP0004142_abnormal_muscle_tone	2.09094985
12	MP0002102_abnormal_ear_morphology	2.08839094
13	MP0009745_abnormal_behavioral_response	2.07941796
14	MP0008872_abnormal_physiological_respon	2.05386133
15	MP0006292_abnormal_olfactory_placode	2.03885821
16	MP0009046_muscle_twitch	1.98779752
17	MP0004742_abnormal_vestibular_system	1.97437623
18	MP0000631_abnormal_neuroendocrine_gland	1.95183501
19	MP0004133_heterotaxia	1.90032671
20	MP0006072_abnormal_retinal_apoptosis	1.88996459
21	MP0002272_abnormal_nervous_system	1.85102964
22	MP0002736_abnormal_nociception_after	1.81185078
23	MP0002735_abnormal_chemical_nociception	1.70235021
24	MP0001986_abnormal_taste_sensitivity	1.62782237
25	MP0004145_abnormal_muscle_electrophysio	1.61062242
26	MP0008877_abnormal_DNA_methylation	1.60683846
27	MP0002638_abnormal_pupillary_reflex	1.60163320
28	MP0002277_abnormal_respiratory_mucosa	1.59047808
29	MP0005171_absent_coat_pigmentation	1.57541655
30	MP0002064_seizures	1.56980753
31	MP0002160_abnormal_reproductive_system	1.55446543
32	MP0001501_abnormal_sleep_pattern	1.54455954
33	MP0005253_abnormal_eye_physiology	1.53893002
34	MP0003646_muscle_fatigue	1.51640345
35	MP0003283_abnormal_digestive_organ	1.51637640
36	MP0005084_abnormal_gallbladder_morpholo	1.50848407
37	MP0008875_abnormal_xenobiotic_pharmacok	1.50250037
38	MP0003011_delayed_dark_adaptation	1.45207161
39	MP0002572_abnormal_emotion/affect_behav	1.40707972
40	MP0004043_abnormal_pH_regulation	1.36828661
41	MP0001529_abnormal_vocalization	1.36648293
42	MP0005646_abnormal_pituitary_gland	1.35676279
43	MP0002067_abnormal_sensory_capabilities	1.33950824
44	MP0000049_abnormal_middle_ear	1.31390262
45	MP0005389_reproductive_system_phenotype	1.29363553
46	MP0005645_abnormal_hypothalamus_physiol	1.29018033
47	MP0001486_abnormal_startle_reflex	1.28403784
48	MP0002557_abnormal_social/conspecific_i	1.27281476
49	MP0002733_abnormal_thermal_nociception	1.27079670
50	MP0002837_dystrophic_cardiac_calcinosis	1.27017045
51	MP0002876_abnormal_thyroid_physiology	1.25603341
52	MP0003880_abnormal_central_pattern	1.23991522
53	MP0001970_abnormal_pain_threshold	1.22094034
54	MP0005423_abnormal_somatic_nervous	1.21351339
55	MP0002734_abnormal_mechanical_nocicepti	1.21121679
56	MP0005174_abnormal_tail_pigmentation	1.20997222
57	MP0005195_abnormal_posterior_eye	1.20434369
58	MP0000026_abnormal_inner_ear	1.20259585
59	MP0003119_abnormal_digestive_system	1.19259688
60	MP0000427_abnormal_hair_cycle	1.18034962
61	MP0003937_abnormal_limbs/digits/tail_de	1.14668575
62	MP0003635_abnormal_synaptic_transmissio	1.13893897
63	MP0000372_irregular_coat_pigmentation	1.12595496
64	MP0000778_abnormal_nervous_system	1.09176741
65	MP0002063_abnormal_learning/memory/cond	1.08962891
66	MP0002928_abnormal_bile_duct	1.08791050
67	MP0003890_abnormal_embryonic-extraembry	1.07607740
68	MP0006276_abnormal_autonomic_nervous	1.06033301
69	MP0000383_abnormal_hair_follicle	1.04430708
70	MP0000566_synostosis	1.01959355
71	MP0002751_abnormal_autonomic_nervous	1.01683073
72	MP0009384_cardiac_valve_regurgitation	1.01271602
73	MP0005386_behavior/neurological_phenoty	1.01133676
74	MP0004924_abnormal_behavior	1.01133676
75	MP0002752_abnormal_somatic_nervous	0.99816891
76	MP0001293_anophthalmia	0.99186131
77	MP0001905_abnormal_dopamine_level	0.98466060
78	MP0005085_abnormal_gallbladder_physiolo	0.97991913
79	MP0002282_abnormal_trachea_morphology	0.97500791
80	MP0005503_abnormal_tendon_morphology	0.95958164
81	MP0004130_abnormal_muscle_cell	0.94728117
82	MP0001919_abnormal_reproductive_system	0.92498297
83	MP0001984_abnormal_olfaction	0.91903876
84	MP0003718_maternal_effect	0.91881518
85	MP0001963_abnormal_hearing_physiology	0.86561908
86	MP0005083_abnormal_biliary_tract	0.86100467
87	MP0002095_abnormal_skin_pigmentation	0.85851505
88	MP0003315_abnormal_perineum_morphology	0.85308040
89	MP0002138_abnormal_hepatobiliary_system	0.81734247
90	MP0004147_increased_porphyrin_level	0.80896353
91	MP0009250_abnormal_appendicular_skeleto	0.79867482
92	MP0004215_abnormal_myocardial_fiber	0.79450353
93	MP0003638_abnormal_response/metabolism_	0.79047190
94	MP0003137_abnormal_impulse_conducting	0.78492559
95	MP0003698_abnormal_male_reproductive	0.77709281
96	MP0005377_hearing/vestibular/ear_phenot	0.77532775
97	MP0003878_abnormal_ear_physiology	0.77532775
98	MP0005187_abnormal_penis_morphology	0.76198195
99	MP0000230_abnormal_systemic_arterial	0.76042073
100	MP0002184_abnormal_innervation	0.75261222

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.30941380
2	Congenital, generalized hypertrichosis (HP:0004540)	4.16215083
3	True hermaphroditism (HP:0010459)	4.13948729
4	Abnormality of midbrain morphology (HP:0002418)	3.99814347
5	Molar tooth sign on MRI (HP:0002419)	3.99814347
6	Pancreatic fibrosis (HP:0100732)	3.90194916
7	Type II lissencephaly (HP:0007260)	3.78701493
8	Nephronophthisis (HP:0000090)	3.58794901
9	Large for gestational age (HP:0001520)	3.23662597
10	Pendular nystagmus (HP:0012043)	3.14739304
11	Congenital stationary night blindness (HP:0007642)	3.11820417
12	Abnormality of the renal medulla (HP:0100957)	3.10904512
13	Furrowed tongue (HP:0000221)	3.10814494
14	Abnormality of the renal cortex (HP:0011035)	3.01741164
15	Abnormality of the pons (HP:0007361)	2.96507863
16	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.94512594
17	Abnormality of alanine metabolism (HP:0010916)	2.94512594
18	Hyperalaninemia (HP:0003348)	2.94512594
19	Hyperventilation (HP:0002883)	2.93644358
20	Hypoplasia of the pons (HP:0012110)	2.88428037
21	Tubular atrophy (HP:0000092)	2.87950304
22	Abnormal number of erythroid precursors (HP:0012131)	2.87819619
23	Concave nail (HP:0001598)	2.80156043
24	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.72837070
25	Absent/shortened dynein arms (HP:0200106)	2.72837070
26	Cystic liver disease (HP:0006706)	2.60327884
27	Cerebellar dysplasia (HP:0007033)	2.60150214
28	Birth length less than 3rd percentile (HP:0003561)	2.56663221
29	Severe muscular hypotonia (HP:0006829)	2.53152872
30	Abolished electroretinogram (ERG) (HP:0000550)	2.52673070
31	Sclerocornea (HP:0000647)	2.51139174
32	Attenuation of retinal blood vessels (HP:0007843)	2.50231424
33	Genetic anticipation (HP:0003743)	2.48978450
34	Medial flaring of the eyebrow (HP:0010747)	2.46032858
35	Abnormality of cells of the erythroid lineage (HP:0012130)	2.44505971
36	Increased corneal curvature (HP:0100692)	2.42358711
37	Keratoconus (HP:0000563)	2.42358711
38	Progressive cerebellar ataxia (HP:0002073)	2.40325449
39	Inability to walk (HP:0002540)	2.33868649
40	Patellar aplasia (HP:0006443)	2.33210957
41	Aplasia/Hypoplasia of the patella (HP:0006498)	2.31619491
42	Abnormal respiratory motile cilium morphology (HP:0005938)	2.27441693
43	Abnormal respiratory epithelium morphology (HP:0012253)	2.27441693
44	Duplicated collecting system (HP:0000081)	2.22345330
45	Abnormality of the renal collecting system (HP:0004742)	2.21265806
46	Gaze-evoked nystagmus (HP:0000640)	2.20535252
47	Septo-optic dysplasia (HP:0100842)	2.20327121
48	Hypothermia (HP:0002045)	2.17642197
49	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	2.17223162
50	Abnormal ciliary motility (HP:0012262)	2.16922274
51	Acute necrotizing encephalopathy (HP:0006965)	2.15973208
52	3-Methylglutaconic aciduria (HP:0003535)	2.14875612
53	Meningioma (HP:0002858)	2.13516875
54	Short hallux (HP:0010109)	2.13508660
55	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.12260097
56	Chorioretinal atrophy (HP:0000533)	2.10421301
57	Lissencephaly (HP:0001339)	2.10097042
58	Limb dystonia (HP:0002451)	2.08756910
59	Conjunctival hamartoma (HP:0100780)	2.08226962
60	Male pseudohermaphroditism (HP:0000037)	2.07022275
61	Anencephaly (HP:0002323)	2.07000080
62	Optic nerve hypoplasia (HP:0000609)	2.06704233
63	Mitochondrial inheritance (HP:0001427)	2.02687599
64	Chronic hepatic failure (HP:0100626)	2.02020839
65	Hemiparesis (HP:0001269)	2.00134895
66	Hypoplastic ischia (HP:0003175)	1.97977109
67	Aplasia/Hypoplasia of the hallux (HP:0008362)	1.97791101
68	Progressive inability to walk (HP:0002505)	1.95493815
69	Congenital hepatic fibrosis (HP:0002612)	1.94905597
70	Polydipsia (HP:0001959)	1.94379222
71	Abnormal drinking behavior (HP:0030082)	1.94379222
72	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.90245642
73	Tachypnea (HP:0002789)	1.90020511
74	Optic disc pallor (HP:0000543)	1.89816585
75	Absent thumb (HP:0009777)	1.89038885
76	Decreased central vision (HP:0007663)	1.88116155
77	Progressive macrocephaly (HP:0004481)	1.87216576
78	Lipid accumulation in hepatocytes (HP:0006561)	1.86993614
79	Pheochromocytoma (HP:0002666)	1.85610342
80	Bilateral microphthalmos (HP:0007633)	1.83696636
81	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.83631417
82	Acute encephalopathy (HP:0006846)	1.82568825
83	Gait imbalance (HP:0002141)	1.82495177
84	Prominent supraorbital ridges (HP:0000336)	1.81587152
85	Reticulocytopenia (HP:0001896)	1.81135433
86	Focal motor seizures (HP:0011153)	1.80827613
87	Abnormality of the carotid arteries (HP:0005344)	1.80369425
88	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.79664984
89	Mesangial abnormality (HP:0001966)	1.78733764
90	Protruding tongue (HP:0010808)	1.78389125
91	Broad-based gait (HP:0002136)	1.78351962
92	Ulnar claw (HP:0001178)	1.77988501
93	Increased CSF lactate (HP:0002490)	1.77906340
94	Renal cortical cysts (HP:0000803)	1.77797116
95	Bone cyst (HP:0012062)	1.77143813
96	Abnormal rod and cone electroretinograms (HP:0008323)	1.75058499
97	Increased hepatocellular lipid droplets (HP:0006565)	1.74768971
98	Agitation (HP:0000713)	1.74594141
99	Tinnitus (HP:0000360)	1.72393334
100	Abnormal mitochondria in muscle tissue (HP:0008316)	1.71719726

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PNCK	4.29474795
2	FRK	4.02333785
3	ADRBK2	3.56014848
4	BMPR1B	3.35885796
5	ZAK	3.21004244
6	GRK1	2.72046863
7	ACVR1B	2.71180358
8	WEE1	2.62007928
9	MAPK15	2.33506905
10	TLK1	2.23039689
11	WNK4	2.21704499
12	WNK3	2.19904119
13	INSRR	2.13049635
14	CASK	2.12052687
15	TSSK6	1.99174277
16	VRK1	1.82945228
17	MAPK13	1.82024014
18	TGFBR1	1.75684928
19	TAOK3	1.73886927
20	PINK1	1.59916820
21	MAP4K2	1.59696288
22	NUAK1	1.56814041
23	MAPKAPK5	1.55892753
24	TAF1	1.49937708
25	MKNK2	1.47675468
26	DAPK2	1.44367063
27	MAP3K4	1.42022220
28	IRAK1	1.41161846
29	ADRBK1	1.37050571
30	VRK2	1.33381191
31	TNIK	1.32885186
32	STK39	1.22891923
33	OXSR1	1.20759085
34	MARK1	1.19826239
35	PRKCG	1.19180294
36	BRSK2	1.14009791
37	NTRK3	1.13213954
38	DYRK2	1.10643566
39	TIE1	1.10409339
40	CAMKK2	1.06191330
41	PTK2B	1.03292839
42	PKN1	0.93578931
43	RPS6KA5	0.92263614
44	PLK4	0.89782326
45	NTRK2	0.89637930
46	NME1	0.88936403
47	PAK3	0.88386618
48	CAMK1D	0.87019105
49	PLK3	0.85428108
50	NEK2	0.80302556
51	MKNK1	0.79106464
52	MAP2K7	0.77473086
53	MAPKAPK3	0.76890726
54	PRKCE	0.71064007
55	CDC7	0.70482888
56	MUSK	0.69100810
57	BUB1	0.63820935
58	MAP2K2	0.59851367
59	CAMK1G	0.58527852
60	CAMK2A	0.58397202
61	MAP2K1	0.56600113
62	CHEK2	0.53175101
63	IRAK4	0.50058101
64	PHKG1	0.49143722
65	PHKG2	0.49143722
66	STK11	0.48646653
67	KIT	0.48239390
68	RPS6KA6	0.47060009
69	CDK3	0.46987685
70	DYRK3	0.46901558
71	EPHB2	0.46645708
72	PRKACA	0.43921697
73	TRPM7	0.42721009
74	PIK3CA	0.41284303
75	STK38L	0.40752675
76	CAMK1	0.39980752
77	PLK1	0.39808253
78	PRKCQ	0.39044052
79	NEK9	0.38146408
80	EPHA4	0.36988474
81	PLK2	0.36267893
82	ERBB2	0.35479053
83	CSNK1G2	0.34963669
84	MAP2K4	0.33809336
85	PRKG1	0.33766488
86	MAP2K6	0.33688016
87	IKBKB	0.32731672
88	GRK7	0.31790228
89	PRKCI	0.30697659
90	CSNK1A1	0.30605412
91	OBSCN	0.30362262
92	STK3	0.28704804
93	CHUK	0.28244536
94	PASK	0.28184502
95	PRKCZ	0.26418945
96	PRKCA	0.25896453
97	CSNK1G1	0.24650808
98	CAMK2B	0.23805468
99	MET	0.21932259
100	CSNK2A1	0.21911234

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	2.99034347
2	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.85559095
3	Nitrogen metabolism_Homo sapiens_hsa00910	2.83163782
4	Linoleic acid metabolism_Homo sapiens_hsa00591	2.78687299
5	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.69201939
6	Phototransduction_Homo sapiens_hsa04744	2.55300298
7	Parkinsons disease_Homo sapiens_hsa05012	2.44642992
8	Nicotine addiction_Homo sapiens_hsa05033	2.41985219
9	Ribosome_Homo sapiens_hsa03010	2.38680569
10	Selenocompound metabolism_Homo sapiens_hsa00450	2.34695720
11	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.27696479
12	Homologous recombination_Homo sapiens_hsa03440	2.09328355
13	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.04277266
14	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.02637779
15	Butanoate metabolism_Homo sapiens_hsa00650	1.99240852
16	Tryptophan metabolism_Homo sapiens_hsa00380	1.93528258
17	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.89500396
18	Ether lipid metabolism_Homo sapiens_hsa00565	1.80151152
19	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.76059972
20	Huntingtons disease_Homo sapiens_hsa05016	1.67787393
21	Cardiac muscle contraction_Homo sapiens_hsa04260	1.65197947
22	Alzheimers disease_Homo sapiens_hsa05010	1.64513949
23	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.64301131
24	Protein export_Homo sapiens_hsa03060	1.57118603
25	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.49734517
26	RNA polymerase_Homo sapiens_hsa03020	1.42737568
27	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.40289848
28	Fanconi anemia pathway_Homo sapiens_hsa03460	1.39310787
29	Taste transduction_Homo sapiens_hsa04742	1.38115989
30	Basal transcription factors_Homo sapiens_hsa03022	1.37914972
31	Morphine addiction_Homo sapiens_hsa05032	1.35236487
32	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.34032537
33	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.24570569
34	Olfactory transduction_Homo sapiens_hsa04740	1.17871044
35	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.16250829
36	Chemical carcinogenesis_Homo sapiens_hsa05204	1.10704838
37	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.10185803
38	Basal cell carcinoma_Homo sapiens_hsa05217	1.09489682
39	Glutamatergic synapse_Homo sapiens_hsa04724	1.08990921
40	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.03451129
41	Cocaine addiction_Homo sapiens_hsa05030	1.02793089
42	Caffeine metabolism_Homo sapiens_hsa00232	1.01743294
43	Serotonergic synapse_Homo sapiens_hsa04726	0.97274830
44	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.97213872
45	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.96079082
46	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.94475494
47	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.93488497
48	Circadian entrainment_Homo sapiens_hsa04713	0.91414137
49	GABAergic synapse_Homo sapiens_hsa04727	0.90017527
50	Insulin secretion_Homo sapiens_hsa04911	0.89801422
51	RNA degradation_Homo sapiens_hsa03018	0.86447746
52	One carbon pool by folate_Homo sapiens_hsa00670	0.86214153
53	Histidine metabolism_Homo sapiens_hsa00340	0.83804270
54	ABC transporters_Homo sapiens_hsa02010	0.83354014
55	Peroxisome_Homo sapiens_hsa04146	0.82467528
56	Glycerolipid metabolism_Homo sapiens_hsa00561	0.82226216
57	Sulfur relay system_Homo sapiens_hsa04122	0.82168068
58	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.79740419
59	Calcium signaling pathway_Homo sapiens_hsa04020	0.79603124
60	Fat digestion and absorption_Homo sapiens_hsa04975	0.78508957
61	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.74665137
62	Sulfur metabolism_Homo sapiens_hsa00920	0.74637381
63	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.73274565
64	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.72162273
65	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.69581857
66	Retinol metabolism_Homo sapiens_hsa00830	0.69497775
67	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.68425592
68	Propanoate metabolism_Homo sapiens_hsa00640	0.67611290
69	Asthma_Homo sapiens_hsa05310	0.64229726
70	Mineral absorption_Homo sapiens_hsa04978	0.63007735
71	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.62494013
72	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.60867576
73	beta-Alanine metabolism_Homo sapiens_hsa00410	0.59779781
74	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.58607153
75	Purine metabolism_Homo sapiens_hsa00230	0.58258211
76	Alcoholism_Homo sapiens_hsa05034	0.55175822
77	Amphetamine addiction_Homo sapiens_hsa05031	0.52665734
78	Long-term depression_Homo sapiens_hsa04730	0.51825765
79	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.51614498
80	Metabolic pathways_Homo sapiens_hsa01100	0.49613461
81	Salivary secretion_Homo sapiens_hsa04970	0.48100384
82	Dopaminergic synapse_Homo sapiens_hsa04728	0.46623137
83	cAMP signaling pathway_Homo sapiens_hsa04024	0.45788876
84	Nucleotide excision repair_Homo sapiens_hsa03420	0.44658257
85	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.42390009
86	Cholinergic synapse_Homo sapiens_hsa04725	0.40650645
87	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.39144341
88	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.37382486
89	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.35821914
90	Axon guidance_Homo sapiens_hsa04360	0.35414455
91	Regulation of autophagy_Homo sapiens_hsa04140	0.34988644
92	Hippo signaling pathway_Homo sapiens_hsa04390	0.34303498
93	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.34132139
94	Collecting duct acid secretion_Homo sapiens_hsa04966	0.33755455
95	Pyrimidine metabolism_Homo sapiens_hsa00240	0.33303313
96	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.33243545
97	Steroid biosynthesis_Homo sapiens_hsa00100	0.31836979
98	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.31574771
99	Bile secretion_Homo sapiens_hsa04976	0.30864773
100	Gastric acid secretion_Homo sapiens_hsa04971	0.25033205

FAM110D

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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