FAM114A2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)5.89272756
2centriole replication (GO:0007099)5.69831041
3regulation of meiosis I (GO:0060631)4.87194173
4rRNA methylation (GO:0031167)4.68331394
5maturation of SSU-rRNA (GO:0030490)4.67260871
6viral transcription (GO:0019083)4.65665470
7SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.61316840
8translational termination (GO:0006415)4.53249218
9cotranslational protein targeting to membrane (GO:0006613)4.49324739
10protein targeting to ER (GO:0045047)4.48352641
11DNA double-strand break processing (GO:0000729)4.38360880
12establishment of protein localization to endoplasmic reticulum (GO:0072599)4.34074340
13rRNA modification (GO:0000154)4.30502338
14piRNA metabolic process (GO:0034587)4.25657712
15ribosomal large subunit biogenesis (GO:0042273)4.19149327
16protein localization to endoplasmic reticulum (GO:0070972)4.17189559
17CENP-A containing nucleosome assembly (GO:0034080)4.14595892
18ribosomal small subunit biogenesis (GO:0042274)4.14457106
19translational elongation (GO:0006414)3.99926235
20DNA methylation involved in gamete generation (GO:0043046)3.81149517
21chromatin remodeling at centromere (GO:0031055)3.75145948
22Golgi transport vesicle coating (GO:0048200)3.71257604
23COPI coating of Golgi vesicle (GO:0048205)3.71257604
24prenylation (GO:0097354)3.70781312
25protein prenylation (GO:0018342)3.70781312
26peptide catabolic process (GO:0043171)3.70561609
27centriole assembly (GO:0098534)3.69508956
28viral life cycle (GO:0019058)3.67831984
29translational initiation (GO:0006413)3.62472304
30protein-chromophore linkage (GO:0018298)3.57225558
31histone exchange (GO:0043486)3.51615094
32adenosine metabolic process (GO:0046085)3.50537420
33synapsis (GO:0007129)3.47729602
34formation of translation preinitiation complex (GO:0001731)3.47663476
35nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.45784727
36sphingosine metabolic process (GO:0006670)3.42911775
37regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.39333090
38cellular protein complex disassembly (GO:0043624)3.36862683
39acrosome assembly (GO:0001675)3.35829917
40heme transport (GO:0015886)3.33781407
41microtubule depolymerization (GO:0007019)3.30376858
42intraciliary transport (GO:0042073)3.29849440
43ribonucleoprotein complex disassembly (GO:0032988)3.28709477
44positive regulation of receptor biosynthetic process (GO:0010870)3.26539563
45translation (GO:0006412)3.25076728
46viral mRNA export from host cell nucleus (GO:0046784)3.22630630
47positive regulation of Cdc42 GTPase activity (GO:0043089)3.20594751
48negative regulation of DNA-dependent DNA replication (GO:2000104)3.17717523
49organelle disassembly (GO:1903008)3.16395638
50regulation of DNA endoreduplication (GO:0032875)3.13808182
51lipid particle organization (GO:0034389)3.13721305
52negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)3.10648415
53short-chain fatty acid metabolic process (GO:0046459)3.10601703
54DNA deamination (GO:0045006)3.07065658
55DNA ligation (GO:0006266)3.05905501
56peroxisome fission (GO:0016559)3.05264747
57RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.04644757
58tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.04644757
59imidazole-containing compound metabolic process (GO:0052803)3.02882392
60protein complex disassembly (GO:0043241)2.97570894
61sphingoid metabolic process (GO:0046519)2.97404251
62spermatid nucleus differentiation (GO:0007289)2.96725215
63protein targeting to membrane (GO:0006612)2.94642026
64DNA replication-independent nucleosome assembly (GO:0006336)2.94477320
65DNA replication-independent nucleosome organization (GO:0034724)2.94477320
66diol metabolic process (GO:0034311)2.93511124
67peptidyl-histidine modification (GO:0018202)2.91712629
68COPII vesicle coating (GO:0048208)2.91364538
69exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.90603564
70metaphase plate congression (GO:0051310)2.89791403
71nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.87557841
72mitotic metaphase plate congression (GO:0007080)2.87179972
73fat-soluble vitamin biosynthetic process (GO:0042362)2.86357585
74regulation of transforming growth factor beta2 production (GO:0032909)2.85994833
75macromolecular complex disassembly (GO:0032984)2.84758497
76glycerol ether metabolic process (GO:0006662)2.82523026
77male meiosis I (GO:0007141)2.81956282
78neural tube formation (GO:0001841)2.80908993
79production of molecular mediator involved in inflammatory response (GO:0002532)2.80404091
80regulation of protein glycosylation (GO:0060049)2.79711153
81GDP-mannose metabolic process (GO:0019673)2.78953980
82cyclooxygenase pathway (GO:0019371)2.77662297
83negative regulation of metanephros development (GO:0072217)2.75918307
84regulation of nuclear cell cycle DNA replication (GO:0033262)2.75312347
85maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.75202881
86negative regulation of neurological system process (GO:0031645)2.74589809
87protein K11-linked ubiquitination (GO:0070979)2.74485009
88antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.73889138
89detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)2.72791882
90establishment of chromosome localization (GO:0051303)2.72256261
91transcription elongation from RNA polymerase III promoter (GO:0006385)2.72130679
92termination of RNA polymerase III transcription (GO:0006386)2.72130679
93mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.71909088
94positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.71909088
95resolution of meiotic recombination intermediates (GO:0000712)2.70303760
96reciprocal DNA recombination (GO:0035825)2.70198414
97reciprocal meiotic recombination (GO:0007131)2.70198414
98IMP biosynthetic process (GO:0006188)2.68416207
99branched-chain amino acid catabolic process (GO:0009083)2.68386642
100chromosome organization involved in meiosis (GO:0070192)2.67584879
101histone-serine phosphorylation (GO:0035404)2.67011803
102regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.64627506
103DNA synthesis involved in DNA repair (GO:0000731)2.64466283
104negative regulation of signal transduction by p53 class mediator (GO:1901797)2.62295640
105mitochondrial RNA metabolic process (GO:0000959)2.62036132
106meiotic cell cycle process (GO:1903046)2.61695583
107regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)2.61483600
108positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)2.61483600
109protein neddylation (GO:0045116)2.61088165
110sterol biosynthetic process (GO:0016126)2.60830774
111antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.60536767
112regulation of centriole replication (GO:0046599)2.59760618
113ether metabolic process (GO:0018904)2.59252326
114negative regulation of cell cycle G2/M phase transition (GO:1902750)2.59236906
115ubiquinone metabolic process (GO:0006743)2.59208114
116regulation of dendritic cell antigen processing and presentation (GO:0002604)2.58972771
117mitochondrial DNA replication (GO:0006264)2.56273614
118meiotic cell cycle (GO:0051321)2.54561914
119interferon-gamma secretion (GO:0072643)2.53934600
120meiosis I (GO:0007127)2.53763414
121IMP metabolic process (GO:0046040)2.53716329
122ether lipid metabolic process (GO:0046485)2.52627257
123signal peptide processing (GO:0006465)2.52083135
124water-soluble vitamin biosynthetic process (GO:0042364)2.52052390
125positive regulation of antigen processing and presentation (GO:0002579)2.51790234
126ribonucleoprotein complex biogenesis (GO:0022613)2.51774378
127platelet dense granule organization (GO:0060155)2.51356464
128biotin metabolic process (GO:0006768)2.50137906
129branched-chain amino acid metabolic process (GO:0009081)2.49378568
130nuclear-transcribed mRNA catabolic process (GO:0000956)2.49034957
131ubiquinone biosynthetic process (GO:0006744)2.48981344
132epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.48067720
133regulation of acyl-CoA biosynthetic process (GO:0050812)2.47590557
134negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.47311680
135valine metabolic process (GO:0006573)2.45963897
136spindle checkpoint (GO:0031577)2.45853980
137mitochondrial calcium ion transport (GO:0006851)2.45747173
138regulation of interleukin-8 secretion (GO:2000482)2.45528426
139regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033392.45171188
140replication fork processing (GO:0031297)2.44716638
141galactose catabolic process (GO:0019388)2.44204906
142mRNA catabolic process (GO:0006402)2.35019604
143DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.34973176
144cullin deneddylation (GO:0010388)2.34157249
145positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.32792623
146regulation of lipoprotein particle clearance (GO:0010984)2.32069736
147signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.31293818
148intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.31293818
149antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.29997778
150protein retention in ER lumen (GO:0006621)2.29912505
151protein deneddylation (GO:0000338)2.29656563
152signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.28377700
153signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.28377700
154signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.28377700
155regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.27715800
156GMP metabolic process (GO:0046037)2.26650830
157intestinal epithelial cell development (GO:0060576)2.25688397
158signal transduction involved in DNA damage checkpoint (GO:0072422)2.24062676
159signal transduction involved in DNA integrity checkpoint (GO:0072401)2.24062676
160signal transduction involved in cell cycle checkpoint (GO:0072395)2.23474673
161pteridine-containing compound biosynthetic process (GO:0042559)2.22864135
162regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.21281782
163tRNA aminoacylation for protein translation (GO:0006418)2.18808513
164regulation of cellular amino acid metabolic process (GO:0006521)2.16301727
165RNA catabolic process (GO:0006401)2.15035490
166negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 2.14495785
167negative regulation of translational initiation (GO:0045947)2.13828176
168tRNA aminoacylation (GO:0043039)2.13634790
169amino acid activation (GO:0043038)2.13634790
170positive regulation of transcription regulatory region DNA binding (GO:2000679)2.13357673
171regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.12440440
172nucleotide-sugar biosynthetic process (GO:0009226)2.12317408
173negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.11408975
174negative regulation of ligase activity (GO:0051352)2.11408975
175histone H2A monoubiquitination (GO:0035518)2.11005446
176hydrogen peroxide catabolic process (GO:0042744)2.10559224
177regulation of antigen processing and presentation (GO:0002577)2.09843594
178proteasome assembly (GO:0043248)2.07164521
179positive regulation of interleukin-8 secretion (GO:2000484)2.06213095
180folic acid-containing compound biosynthetic process (GO:0009396)2.05851181
181anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.05501686
182protoporphyrinogen IX biosynthetic process (GO:0006782)2.04829869
183endosome to pigment granule transport (GO:0043485)2.04303627
184endosome to melanosome transport (GO:0035646)2.04303627
185protoporphyrinogen IX metabolic process (GO:0046501)2.04047467
186UDP-N-acetylglucosamine metabolic process (GO:0006047)2.03745492
187proline biosynthetic process (GO:0006561)2.03520323
188leukotriene biosynthetic process (GO:0019370)2.02559292
189positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.02097624

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.23329508
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.21323192
3E2F7_22180533_ChIP-Seq_HELA_Human3.15880353
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.14270288
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.14039740
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.07484392
7ELF1_17652178_ChIP-ChIP_JURKAT_Human3.01618257
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.91868961
9POU3F2_20337985_ChIP-ChIP_501MEL_Human2.74884605
10* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.72598978
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.71003775
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.65560497
13IGF1R_20145208_ChIP-Seq_DFB_Human2.57885960
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.53596430
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.41197971
16* DCP1A_22483619_ChIP-Seq_HELA_Human2.39087355
17FUS_26573619_Chip-Seq_HEK293_Human2.31125438
18MYC_18358816_ChIP-ChIP_MESCs_Mouse2.25767055
19ZNF274_21170338_ChIP-Seq_K562_Hela2.21915502
20MYC_19079543_ChIP-ChIP_MESCs_Mouse2.20451088
21FLI1_27457419_Chip-Seq_LIVER_Mouse2.18824138
22MYC_19030024_ChIP-ChIP_MESCs_Mouse2.10865109
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.08758384
24* CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.07357108
25E2F1_18555785_ChIP-Seq_MESCs_Mouse2.02939095
26STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.01807519
27NELFA_20434984_ChIP-Seq_ESCs_Mouse1.99743127
28* XRN2_22483619_ChIP-Seq_HELA_Human1.98690325
29VDR_23849224_ChIP-Seq_CD4+_Human1.97584596
30SALL1_21062744_ChIP-ChIP_HESCs_Human1.95246590
31ZFP57_27257070_Chip-Seq_ESCs_Mouse1.93312178
32GATA1_22025678_ChIP-Seq_K562_Human1.92646470
33BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.89694098
34EWS_26573619_Chip-Seq_HEK293_Human1.89264341
35PCGF2_27294783_Chip-Seq_ESCs_Mouse1.86247256
36* P300_19829295_ChIP-Seq_ESCs_Human1.85214746
37* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.83973373
38SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.83212256
39SRF_21415370_ChIP-Seq_HL-1_Mouse1.83047215
40PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.82814389
41FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.82605589
42ELK1_19687146_ChIP-ChIP_HELA_Human1.80486045
43TP63_17297297_ChIP-ChIP_HaCaT_Human1.79764218
44FOXP3_21729870_ChIP-Seq_TREG_Human1.77216335
45HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.75964605
46HOXB4_20404135_ChIP-ChIP_EML_Mouse1.75680010
47TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.75594160
48EZH2_27294783_Chip-Seq_NPCs_Mouse1.75273819
49KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.74980925
50KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.74980925
51KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.74980925
52TAF15_26573619_Chip-Seq_HEK293_Human1.74823013
53AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.72266675
54FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.71929357
55HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.71386928
56STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.69568785
57TTF2_22483619_ChIP-Seq_HELA_Human1.68734903
58PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.68534229
59PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.66159091
60SUZ12_27294783_Chip-Seq_NPCs_Mouse1.65979880
61CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.65679815
62CIITA_25753668_ChIP-Seq_RAJI_Human1.63414593
63SMAD_19615063_ChIP-ChIP_OVARY_Human1.62029873
64GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.61367592
65CTBP2_25329375_ChIP-Seq_LNCAP_Human1.59291058
66EGR1_19374776_ChIP-ChIP_THP-1_Human1.58120896
67NFE2_27457419_Chip-Seq_LIVER_Mouse1.56938147
68* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.55144062
69SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.54602819
70VDR_22108803_ChIP-Seq_LS180_Human1.53609814
71ER_23166858_ChIP-Seq_MCF-7_Human1.52669796
72FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.52655788
73THAP11_20581084_ChIP-Seq_MESCs_Mouse1.52059068
74* GABP_19822575_ChIP-Seq_HepG2_Human1.51342669
75GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.49672664
76CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.49345839
77* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.49326462
78BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.49131007
79GBX2_23144817_ChIP-Seq_PC3_Human1.48879475
80ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.46511153
81TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.45289843
82ZFX_18555785_ChIP-Seq_MESCs_Mouse1.43619175
83PCGF2_27294783_Chip-Seq_NPCs_Mouse1.42910168
84SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.41939193
85ELK1_22589737_ChIP-Seq_MCF10A_Human1.41119193
86IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.40876854
87CDX2_22108803_ChIP-Seq_LS180_Human1.39894784
88ERG_20887958_ChIP-Seq_HPC-7_Mouse1.38503486
89CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.38345979
90NANOG_18555785_Chip-Seq_ESCs_Mouse1.36362015
91TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.35982023
92RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.35628111
93CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.35459205
94EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.31944046
95UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.31409205
96* CRX_20693478_ChIP-Seq_RETINA_Mouse1.30977680
97CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.30017468
98CLOCK_20551151_ChIP-Seq_293T_Human1.29223900
99CBP_20019798_ChIP-Seq_JUKART_Human1.29163136
100IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.29163136
101MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.27931592
102SMAD4_21799915_ChIP-Seq_A2780_Human1.26495402
103OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26334656
104SOX2_19829295_ChIP-Seq_ESCs_Human1.26245715
105NANOG_19829295_ChIP-Seq_ESCs_Human1.26245715
106HIF1A_21447827_ChIP-Seq_MCF-7_Human1.26092174
107ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.25710507
108KDM5A_27292631_Chip-Seq_BREAST_Human1.24544509
109SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.23182136
110STAT3_23295773_ChIP-Seq_U87_Human1.23118579
111FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.22694243
112* OCT4_21477851_ChIP-Seq_ESCs_Mouse1.20771242
113P300_18555785_Chip-Seq_ESCs_Mouse1.20312577
114MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.20070261
115E2F1_18555785_Chip-Seq_ESCs_Mouse1.19705510
116HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.19469355
117CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.18617246
118P53_22387025_ChIP-Seq_ESCs_Mouse1.18553574
119IRF8_22096565_ChIP-ChIP_GC-B_Human1.18429302
120YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.18239990
121EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.17643363
122MYCN_18555785_ChIP-Seq_MESCs_Mouse1.17470436
123SUZ12_18555785_Chip-Seq_ESCs_Mouse1.17401157
124SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.17114101
125HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.16542422
126MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.16245777
127SALL4_22934838_ChIP-ChIP_CD34+_Human1.15737134
128PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.15023813
129STAT3_18555785_Chip-Seq_ESCs_Mouse1.14893719
130* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.14700274
131SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.12474207
132AR_25329375_ChIP-Seq_VCAP_Human1.12227208
133PADI4_21655091_ChIP-ChIP_MCF-7_Human1.11896730
134SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.11800890
135EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.11561273
136MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.11219901
137BCAT_22108803_ChIP-Seq_LS180_Human1.11102811
138E2F4_17652178_ChIP-ChIP_JURKAT_Human1.10485221
139CMYC_18555785_Chip-Seq_ESCs_Mouse1.10021970
140STAT3_1855785_ChIP-Seq_MESCs_Mouse1.09986198
141PIAS1_25552417_ChIP-Seq_VCAP_Human1.09643985
142FOXA1_21572438_ChIP-Seq_LNCaP_Human1.09456097
143SOX2_18555785_Chip-Seq_ESCs_Mouse1.08520234
144OCT4_18555785_Chip-Seq_ESCs_Mouse1.07352208
145* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.07113627
146HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.06958270
147* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.06841552
148TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06672525
149TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05727247
150TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.05376820
151RBPJ_22232070_ChIP-Seq_NCS_Mouse1.04318969
152BRD4_25478319_ChIP-Seq_HGPS_Human1.04212181
153TP53_22573176_ChIP-Seq_HFKS_Human1.03620105
154NOTCH1_21737748_ChIP-Seq_TLL_Human1.03504780
155POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.02840260
156PPARA_22158963_ChIP-Seq_LIVER_Mouse1.01444749
157KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.00789773
158ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.99510656
159CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.97464361
160TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.97213844
161ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.95596063
162NANOG_18555785_ChIP-Seq_MESCs_Mouse0.95147757
163TFEB_21752829_ChIP-Seq_HELA_Human0.94952712
164SPI1_23547873_ChIP-Seq_NB4_Human0.94406383
165TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.92821759
166* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.92539444
167MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.91097233
168MYC_22102868_ChIP-Seq_BL_Human0.89430922
169KLF4_18555785_ChIP-Seq_MESCs_Mouse0.88650354
170EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.87976438
171DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.87283667
172AR_21909140_ChIP-Seq_LNCAP_Human0.86386973
173RARG_19884340_ChIP-ChIP_MEFs_Mouse0.85683801
174SOX17_20123909_ChIP-Seq_XEN_Mouse0.84128309
175E2F1_21310950_ChIP-Seq_MCF-7_Human0.83547293

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis4.17249401
2MP0008057_abnormal_DNA_replication3.78208215
3MP0005171_absent_coat_pigmentation3.29748733
4MP0003693_abnormal_embryo_hatching2.86370756
5MP0000569_abnormal_digit_pigmentation2.55022018
6MP0002653_abnormal_ependyma_morphology2.54231932
7MP0003806_abnormal_nucleotide_metabolis2.40031293
8MP0008877_abnormal_DNA_methylation2.32753194
9MP0000372_irregular_coat_pigmentation2.09719818
10MP0000685_abnormal_immune_system2.08797292
11MP0004957_abnormal_blastocyst_morpholog2.04249112
12MP0010368_abnormal_lymphatic_system2.02547419
13MP0003011_delayed_dark_adaptation1.93420084
14MP0008995_early_reproductive_senescence1.93090216
15MP0005410_abnormal_fertilization1.91155992
16MP0001835_abnormal_antigen_presentation1.91055967
17MP0003136_yellow_coat_color1.72882009
18MP0002876_abnormal_thyroid_physiology1.68706724
19MP0001873_stomach_inflammation1.67525402
20MP0003890_abnormal_embryonic-extraembry1.66933228
21MP0001929_abnormal_gametogenesis1.65148348
22MP0008058_abnormal_DNA_repair1.57592756
23MP0005395_other_phenotype1.52686963
24MP0002210_abnormal_sex_determination1.52378311
25MP0002132_abnormal_respiratory_system1.50362762
26MP0000490_abnormal_crypts_of1.49006490
27MP0005220_abnormal_exocrine_pancreas1.46573404
28MP0002148_abnormal_hypersensitivity_rea1.45380363
29MP0004215_abnormal_myocardial_fiber1.45007200
30MP0006054_spinal_hemorrhage1.44987636
31MP0003950_abnormal_plasma_membrane1.44504982
32MP0001986_abnormal_taste_sensitivity1.43488877
33MP0005451_abnormal_body_composition1.43415392
34MP0001661_extended_life_span1.41956265
35MP0008007_abnormal_cellular_replicative1.40872508
36MP0001764_abnormal_homeostasis1.40435400
37MP0010307_abnormal_tumor_latency1.39906818
38MP0005501_abnormal_skin_physiology1.38950834
39MP0001666_abnormal_nutrient_absorption1.37893841
40MP0009333_abnormal_splenocyte_physiolog1.35644073
41MP0003045_fibrosis1.34905052
42MP0002160_abnormal_reproductive_system1.34652203
43MP0005367_renal/urinary_system_phenotyp1.33897781
44MP0000516_abnormal_urinary_system1.33897781
45MP0004381_abnormal_hair_follicle1.33855958
46MP0003195_calcinosis1.33451480
47MP0008789_abnormal_olfactory_epithelium1.32861068
48MP0005408_hypopigmentation1.30812710
49MP0000653_abnormal_sex_gland1.29641283
50MP0006035_abnormal_mitochondrial_morpho1.29219170
51MP0005646_abnormal_pituitary_gland1.28631407
52MP0001119_abnormal_female_reproductive1.28382852
53MP0008004_abnormal_stomach_pH1.22052793
54MP0005266_abnormal_metabolism1.20460003
55MP0002060_abnormal_skin_morphology1.18953575
56MP0003698_abnormal_male_reproductive1.18297613
57MP0002796_impaired_skin_barrier1.17770304
58MP0000013_abnormal_adipose_tissue1.17337757
59MP0004084_abnormal_cardiac_muscle1.17163346
60MP0003077_abnormal_cell_cycle1.16807905
61MP0003221_abnormal_cardiomyocyte_apopto1.16660758
62MP0003656_abnormal_erythrocyte_physiolo1.13038550
63MP0005389_reproductive_system_phenotype1.12385081
64MP0001145_abnormal_male_reproductive1.11822587
65MP0002396_abnormal_hematopoietic_system1.11563610
66MP0003718_maternal_effect1.11144270
67MP0010094_abnormal_chromosome_stability1.10363099
68MP0003252_abnormal_bile_duct1.09026019
69MP0002269_muscular_atrophy1.07831344
70MP0005023_abnormal_wound_healing1.07272414
71MP0004782_abnormal_surfactant_physiolog1.06233460
72MP0002168_other_aberrant_phenotype1.06038356
73MP0000762_abnormal_tongue_morphology1.05516823
74MP0005670_abnormal_white_adipose1.05349048
75MP0002938_white_spotting1.03394882
76MP0005275_abnormal_skin_tensile1.03142092
77MP0000647_abnormal_sebaceous_gland1.01598184
78MP0002009_preneoplasia1.01534541
79MP0002127_abnormal_cardiovascular_syste1.00939775
80MP0005075_abnormal_melanosome_morpholog1.00312704
81MP0005647_abnormal_sex_gland1.00285020
82MP0000358_abnormal_cell_content/1.00104566
83MP0000427_abnormal_hair_cycle0.99577524
84MP0002277_abnormal_respiratory_mucosa0.99328657
85MP0010155_abnormal_intestine_physiology0.99298317
86MP0002332_abnormal_exercise_endurance0.98851456
87MP0001542_abnormal_bone_strength0.98450575
88MP0009379_abnormal_foot_pigmentation0.98034312
89MP0005187_abnormal_penis_morphology0.97004167
90MP0003186_abnormal_redox_activity0.96845846
91MP0008932_abnormal_embryonic_tissue0.96288064
92MP0003646_muscle_fatigue0.95885505
93MP0000749_muscle_degeneration0.94722303
94MP0002254_reproductive_system_inflammat0.94442320
95MP0009643_abnormal_urine_homeostasis0.93908755
96MP0002138_abnormal_hepatobiliary_system0.93567134
97MP0005083_abnormal_biliary_tract0.93249341
98MP0003763_abnormal_thymus_physiology0.92738645
99MP0002933_joint_inflammation0.91907950
100MP0009765_abnormal_xenobiotic_induced0.90537542
101MP0003868_abnormal_feces_composition0.88765402
102MP0004147_increased_porphyrin_level0.87846559
103MP0001756_abnormal_urination0.87814387
104MP0005257_abnormal_intraocular_pressure0.86733325
105MP0005330_cardiomyopathy0.85536743
106MP0005379_endocrine/exocrine_gland_phen0.84899665
107MP0006072_abnormal_retinal_apoptosis0.84577723
108MP0004133_heterotaxia0.84385443
109MP0009697_abnormal_copulation0.84280625
110MP0000371_diluted_coat_color0.84199218
111MP0005319_abnormal_enzyme/_coenzyme0.83780915
112MP0005671_abnormal_response_to0.83418642
113MP0003959_abnormal_lean_body0.83058902
114MP0004134_abnormal_chest_morphology0.81948556
115MP0002163_abnormal_gland_morphology0.81538543
116MP0001984_abnormal_olfaction0.81394569
117MP0003137_abnormal_impulse_conducting0.81088046
118MP0001324_abnormal_eye_pigmentation0.79990943
119MP0005085_abnormal_gallbladder_physiolo0.79716909
120MP0002095_abnormal_skin_pigmentation0.78933696
121MP0009384_cardiac_valve_regurgitation0.78243523
122MP0001216_abnormal_epidermal_layer0.78082784
123MP0004145_abnormal_muscle_electrophysio0.77638426
124MP0003786_premature_aging0.77036919
125MP0004142_abnormal_muscle_tone0.76686808
126MP0003567_abnormal_fetal_cardiomyocyte0.75290700
127MP0003183_abnormal_peptide_metabolism0.75227549
128MP0005310_abnormal_salivary_gland0.74950212
129MP0003436_decreased_susceptibility_to0.74907213
130MP0002102_abnormal_ear_morphology0.74481501
131MP0006036_abnormal_mitochondrial_physio0.74280275
132MP0005503_abnormal_tendon_morphology0.73328632
133MP0009764_decreased_sensitivity_to0.73001971
134MP0002098_abnormal_vibrissa_morphology0.72945770
135MP0006082_CNS_inflammation0.72645848
136MP0009053_abnormal_anal_canal0.72264090
137MP0000377_abnormal_hair_follicle0.72114368
138MP0002234_abnormal_pharynx_morphology0.71846075
139MP0001845_abnormal_inflammatory_respons0.71804460
140MP0002166_altered_tumor_susceptibility0.71652631
141MP0005174_abnormal_tail_pigmentation0.70596695
142MP0000858_altered_metastatic_potential0.69903434
143MP0000477_abnormal_intestine_morphology0.69762268
144MP0003111_abnormal_nucleus_morphology0.69152095
145MP0002019_abnormal_tumor_incidence0.68698414
146MP0001348_abnormal_lacrimal_gland0.68317872
147MP0002075_abnormal_coat/hair_pigmentati0.67770470
148MP0005376_homeostasis/metabolism_phenot0.67478812
149MP0001270_distended_abdomen0.66895080
150MP0005332_abnormal_amino_acid0.66339756
151MP0000350_abnormal_cell_proliferation0.65429620
152MP0005551_abnormal_eye_electrophysiolog0.65198324
153MP0005253_abnormal_eye_physiology0.64791044
154MP0002751_abnormal_autonomic_nervous0.63920804
155MP0001800_abnormal_humoral_immune0.63642989
156MP0005365_abnormal_bile_salt0.63149543
157MP0002084_abnormal_developmental_patter0.62636481
158MP0005385_cardiovascular_system_phenoty0.62236167
159MP0001544_abnormal_cardiovascular_syste0.62236167
160MP0010386_abnormal_urinary_bladder0.61593423
161MP0003941_abnormal_skin_development0.61014785

Predicted human phenotypes

RankGene SetZ-score
1Degeneration of anterior horn cells (HP:0002398)5.59676211
2Abnormality of the anterior horn cell (HP:0006802)5.59676211
3Amyotrophic lateral sclerosis (HP:0007354)4.33003413
4Atrophy/Degeneration involving motor neurons (HP:0007373)3.81064544
5Abnormality of the lower motor neuron (HP:0002366)3.56121962
6Abnormality of alanine metabolism (HP:0010916)3.33419818
7Hyperalaninemia (HP:0003348)3.33419818
8Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.33419818
9Pancreatic cysts (HP:0001737)3.32560188
10Conjunctival telangiectasia (HP:0000524)3.31058878
11Hyperglycinemia (HP:0002154)3.00186283
12Chronic hepatic failure (HP:0100626)2.92651535
13Myopathic facies (HP:0002058)2.90700410
14Pancreatic fibrosis (HP:0100732)2.88499342
15Long clavicles (HP:0000890)2.87230318
16Abnormality of the renal cortex (HP:0011035)2.86237086
17Delayed epiphyseal ossification (HP:0002663)2.85037810
18Abnormal rod and cone electroretinograms (HP:0008323)2.83474708
19Molar tooth sign on MRI (HP:0002419)2.82832651
20Abnormality of midbrain morphology (HP:0002418)2.82832651
21Upper motor neuron abnormality (HP:0002127)2.81554907
22Renal cortical cysts (HP:0000803)2.81322388
23Abnormality of the vasculature of the conjunctiva (HP:0008054)2.78653736
24Abnormality of cells of the erythroid lineage (HP:0012130)2.78501254
25Aplastic anemia (HP:0001915)2.73458054
26Severe visual impairment (HP:0001141)2.67429296
27Aplasia/Hypoplasia of the sacrum (HP:0008517)2.63494723
28Right ventricular cardiomyopathy (HP:0011663)2.60979095
29Congenital stationary night blindness (HP:0007642)2.56794970
30Reticulocytopenia (HP:0001896)2.56714396
31Abnormality of macular pigmentation (HP:0008002)2.56485307
32Rhabdomyolysis (HP:0003201)2.56376313
33Medial flaring of the eyebrow (HP:0010747)2.55054390
34Nephronophthisis (HP:0000090)2.54909829
35Hyperglycinuria (HP:0003108)2.47651292
36Increased serum pyruvate (HP:0003542)2.44005891
37Volvulus (HP:0002580)2.43962721
38Aplasia/Hypoplasia of the tongue (HP:0010295)2.43139638
39Congenital primary aphakia (HP:0007707)2.40244059
40Tubulointerstitial nephritis (HP:0001970)2.35977057
41Nephrogenic diabetes insipidus (HP:0009806)2.35710050
42Absent rod-and cone-mediated responses on ERG (HP:0007688)2.35204843
43Abnormality of the renal medulla (HP:0100957)2.34459861
44Abnormality of serum amino acid levels (HP:0003112)2.34047556
45Acute encephalopathy (HP:0006846)2.33280562
46Abnormal hemoglobin (HP:0011902)2.31300566
47Abnormality of the pons (HP:0007361)2.26840077
48Fair hair (HP:0002286)2.25659550
49Type I transferrin isoform profile (HP:0003642)2.23939575
50Bony spicule pigmentary retinopathy (HP:0007737)2.22931375
51Hypoplasia of the pons (HP:0012110)2.22405658
52Abnormal biliary tract physiology (HP:0012439)2.17888942
53Bile duct proliferation (HP:0001408)2.17888942
54Intestinal atresia (HP:0011100)2.17812822
55Nemaline bodies (HP:0003798)2.17101475
56Methylmalonic acidemia (HP:0002912)2.16502755
57Gait imbalance (HP:0002141)2.15804212
58Thrombocytosis (HP:0001894)2.14952483
5911 pairs of ribs (HP:0000878)2.14935810
60Macrocytic anemia (HP:0001972)2.14897994
61Albinism (HP:0001022)2.14543714
62Type 2 muscle fiber atrophy (HP:0003554)2.12851740
63Supernumerary spleens (HP:0009799)2.12103336
64Abnormality of the fetal cardiovascular system (HP:0010948)2.11690928
65Abnormal umbilical cord blood vessels (HP:0011403)2.11690928
66Single umbilical artery (HP:0001195)2.11690928
67Reduced antithrombin III activity (HP:0001976)2.11545900
68Trismus (HP:0000211)2.09935719
69Abnormal trabecular bone morphology (HP:0100671)2.09821662
70Abnormal pancreas size (HP:0012094)2.09552806
71Abolished electroretinogram (ERG) (HP:0000550)2.08714143
72Abnormal number of erythroid precursors (HP:0012131)2.07657595
73Abnormality of fatty-acid metabolism (HP:0004359)2.06709269
74Acute necrotizing encephalopathy (HP:0006965)2.06121240
75Keratoconus (HP:0000563)2.05603168
76Increased corneal curvature (HP:0100692)2.05603168
77Dry hair (HP:0011359)2.05399869
78Central scotoma (HP:0000603)2.04258438
79Oral leukoplakia (HP:0002745)2.03653267
80Thin bony cortex (HP:0002753)1.99664566
81Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.99566263
82Colon cancer (HP:0003003)1.98729083
83Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.98429156
84Abnormal lung lobation (HP:0002101)1.98218304
85Abnormal protein glycosylation (HP:0012346)1.98131836
86Abnormal glycosylation (HP:0012345)1.98131836
87Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.98131836
88Abnormal protein N-linked glycosylation (HP:0012347)1.98131836
89Abnormality of glycine metabolism (HP:0010895)1.98060645
90Abnormality of serine family amino acid metabolism (HP:0010894)1.98060645
91Dyschromatopsia (HP:0007641)1.97978807
92Abnormality of the labia minora (HP:0012880)1.97464008
93Myoglobinuria (HP:0002913)1.97433416
94Muscle fiber inclusion bodies (HP:0100299)1.96091881
95Abnormality of glycolysis (HP:0004366)1.95997733
96Woolly hair (HP:0002224)1.95626583
97Hypoplastic iliac wings (HP:0002866)1.94970684
98Pallor (HP:0000980)1.92656337
99Impaired proprioception (HP:0010831)1.91972619
100Abnormality of aromatic amino acid family metabolism (HP:0004338)1.91405483
101Generalized aminoaciduria (HP:0002909)1.90034740
102Breast hypoplasia (HP:0003187)1.89053451
103Hypothermia (HP:0002045)1.88941783
104Abnormality of methionine metabolism (HP:0010901)1.88207850
105Rough bone trabeculation (HP:0100670)1.87973027
106Abnormality of the intrinsic pathway (HP:0010989)1.87425576
107Anencephaly (HP:0002323)1.87088494
108Aplasia/Hypoplasia of the tibia (HP:0005772)1.87054361
109Short tibia (HP:0005736)1.86383194
110Male pseudohermaphroditism (HP:0000037)1.86118965
111Occipital encephalocele (HP:0002085)1.84922278
112Abnormality of aspartate family amino acid metabolism (HP:0010899)1.84236561
113White forelock (HP:0002211)1.84115728
114Aplasia/Hypoplasia of the uvula (HP:0010293)1.82588495
115Beaking of vertebral bodies (HP:0004568)1.82537680
116Widely patent fontanelles and sutures (HP:0004492)1.82336454
117Hyperammonemia (HP:0001987)1.81905717
118Progressive macrocephaly (HP:0004481)1.81874859
119Gonadal dysgenesis (HP:0000133)1.80451427
120Wide cranial sutures (HP:0010537)1.79332657
121Degeneration of the lateral corticospinal tracts (HP:0002314)1.79222878
122Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.79222878
123Cerebral palsy (HP:0100021)1.78588885
124Abnormality of the corticospinal tract (HP:0002492)1.78584379
125Metabolic acidosis (HP:0001942)1.76965551
126Exercise-induced muscle cramps (HP:0003710)1.76883524
127Hypochromic microcytic anemia (HP:0004840)1.76462617
128Spinal muscular atrophy (HP:0007269)1.75854113
129Hydroxyprolinuria (HP:0003080)1.75808337
130Abnormality of proline metabolism (HP:0010907)1.75808337
131Amniotic constriction ring (HP:0009775)1.75308131
132Abnormality of placental membranes (HP:0011409)1.75308131
133Genital tract atresia (HP:0001827)1.75179765
134Abnormality of the motor neurons (HP:0002450)1.74747535
135Abnormal neuron morphology (HP:0012757)1.74747535
136Sloping forehead (HP:0000340)1.74646992
137Aplasia/Hypoplasia involving the musculature (HP:0001460)1.74329255
138Gonadotropin excess (HP:0000837)1.74258259
139Patchy hypopigmentation of hair (HP:0011365)1.73647429
140Chronic diarrhea (HP:0002028)1.73607195
141Vitreoretinal degeneration (HP:0000655)1.72339553
142Palpitations (HP:0001962)1.72328908
143Cerebral edema (HP:0002181)1.72304340
144Oligodactyly (hands) (HP:0001180)1.72058874
145Micronodular cirrhosis (HP:0001413)1.71793264
146Irregular epiphyses (HP:0010582)1.71194610
147Abnormality of the costochondral junction (HP:0000919)1.70731431
148Concave nail (HP:0001598)1.70275049
149Increased serum lactate (HP:0002151)1.68641658
150Hypoplastic left heart (HP:0004383)1.68490766
151Median cleft lip (HP:0000161)1.68259713
152Congenital sensorineural hearing impairment (HP:0008527)1.67591358
153Ulnar deviation of the wrist (HP:0003049)1.66710051
154Carpal bone hypoplasia (HP:0001498)1.66585682
155Oculomotor apraxia (HP:0000657)1.65803794
156Hepatic necrosis (HP:0002605)1.65616940
157Hypoplastic heart (HP:0001961)1.65609621
158Angiofibromas (HP:0010615)1.65581674
159Adenoma sebaceum (HP:0009720)1.65581674
160Abnormal auditory evoked potentials (HP:0006958)1.64952945
161Constricted visual fields (HP:0001133)1.64726370
162Dicarboxylic aciduria (HP:0003215)1.64077898
163Abnormality of dicarboxylic acid metabolism (HP:0010995)1.64077898
164Seborrheic dermatitis (HP:0001051)1.63983782
165Microvesicular hepatic steatosis (HP:0001414)1.63276231
166Double outlet right ventricle (HP:0001719)1.62721699
167Congenital malformation of the right heart (HP:0011723)1.62721699
168Metaphyseal irregularity (HP:0003025)1.62665376
169Abnormal pupillary function (HP:0007686)1.61781174
170Redundant skin (HP:0001582)1.61610090
171True hermaphroditism (HP:0010459)1.59904944
172Progressive external ophthalmoplegia (HP:0000590)1.58170783
173Proximal tubulopathy (HP:0000114)1.58081876
174Vertebral compression fractures (HP:0002953)1.57052192
175Decreased central vision (HP:0007663)1.55272087
176Rimmed vacuoles (HP:0003805)1.55118962
177Prolonged neonatal jaundice (HP:0006579)1.53484071
178Enlarged epiphyses (HP:0010580)1.52959970
179Abnormal epiphyseal ossification (HP:0010656)1.52722576
180Elevated alkaline phosphatase (HP:0003155)1.52518608

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK2.66509434
2PINK12.52416077
3TLK12.50371009
4LATS12.48676703
5NEK92.44147500
6BCR2.34928331
7RPS6KB22.19361988
8EIF2AK12.14369850
9MAP4K22.13569003
10TGFBR12.08372254
11PKN22.04466734
12FLT31.99496941
13CCNB11.94477401
14STK31.91254800
15BMPR1B1.88849833
16NME11.86842171
17NUAK11.85244969
18PIK3CG1.82728613
19BUB11.75136630
20AKT31.73491297
21NME21.71921961
22MST41.71468396
23PNCK1.71139162
24VRK11.70212873
25MAP3K31.67330567
26PLK21.66043967
27MST1R1.64622408
28ZAK1.61938922
29PLK31.61527157
30MAP2K31.61172458
31ACVR1B1.59871453
32CDK81.56445707
33TRIM281.54261653
34MKNK11.47624429
35ERBB31.46395808
36TSSK61.45211033
37BLK1.44250462
38EIF2AK31.42123788
39DYRK31.37577695
40EPHA31.37551148
41SRPK11.33563509
42STK241.33101779
43ILK1.28190994
44PRKD31.28180244
45WNK31.26174055
46ERN11.25054511
47IRAK31.23185903
48EPHA21.21602724
49PIM21.20234662
50PASK1.16785984
51INSRR1.16776046
52PBK1.14944629
53TGFBR21.14272248
54MAP2K21.12957851
55CDK61.12235472
56TEC1.12109090
57MAP3K141.11404995
58LRRK21.11286783
59BTK1.10685272
60RPS6KA41.10212937
61TNIK1.10003121
62WEE11.09879916
63NLK1.07365835
64STK161.06558440
65STK38L1.06371888
66PLK11.06345417
67MUSK1.06142520
68TXK1.05650711
69MAP3K40.97645030
70STK390.96266840
71TYK20.96030214
72OBSCN0.94551826
73CHUK0.94054906
74FRK0.90836159
75MYLK0.90578345
76MAPK130.89238493
77MAPKAPK30.88589604
78BMPR20.87250204
79STK100.87189106
80BRAF0.86808835
81IRAK40.85589756
82DYRK1B0.85464713
83CASK0.84292242
84TTK0.83900046
85RPS6KA50.82267901
86TRIB30.81806164
87LIMK10.80716226
88TAF10.78800397
89PAK30.78004758
90MAPK150.74259236
91NEK20.73650451
92KIT0.72502903
93PRKCE0.70919268
94PRKCI0.69184635
95IKBKB0.68669485
96TBK10.67298837
97MAP3K100.67050231
98OXSR10.67003427
99PIM10.65567794
100PDK20.65382325
101CSF1R0.64935891
102AURKB0.64659174
103MAP3K120.64106761
104ZAP700.64051784
105EPHB20.63151055
106PTK60.62910217
107NEK10.62367500
108YES10.61802807
109FER0.60981384
110CSNK1A1L0.58578944
111MAP4K10.58297412
112LATS20.58106319
113MET0.57437394
114SGK20.55985810
115MAP3K80.55644757
116GRK10.55564841
117CSNK1G10.55104315
118IRAK10.54829420
119TRPM70.54683025
120MKNK20.54518887
121MAP3K20.54100571
122TIE10.53323533
123ATR0.52252341
124MAPKAPK20.51159957
125STK40.49978789
126EIF2AK20.48977762
127KDR0.48839590
128TTN0.48712939
129VRK20.47599377
130CDK70.46974698
131ATM0.46783222
132RAF10.46308252
133PLK40.45789967
134CSNK2A10.45661385
135MAP3K50.45077660
136BRSK20.44948192
137MAP2K10.44718045
138ADRBK20.44518018
139TAOK30.44346014
140CSNK1G30.43916681
141JAK30.42408538
142CDC70.41905911
143TESK10.41520236
144CSNK1G20.41379543
145CDK190.40347453
146CSNK2A20.40017737
147NEK60.38796129
148ABL10.36493157
149CAMKK20.36311214
150MAP2K70.35181899
151PRKAA20.34929889
152FGR0.34065184
153MELK0.33899112
154ADRBK10.33645068
155BRSK10.33426821
156MARK30.33098672
157PTK2B0.31157245
158CDK40.27960862
159AURKA0.27875430

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030103.96034389
2Protein export_Homo sapiens_hsa030603.54230979
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.43151354
4Proteasome_Homo sapiens_hsa030502.81430799
5RNA polymerase_Homo sapiens_hsa030202.45862244
6Cyanoamino acid metabolism_Homo sapiens_hsa004602.25054689
7Butanoate metabolism_Homo sapiens_hsa006502.15120177
8Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.03438494
9Non-homologous end-joining_Homo sapiens_hsa034502.03295178
10Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.98344499
11Mismatch repair_Homo sapiens_hsa034301.89017597
12Folate biosynthesis_Homo sapiens_hsa007901.88627083
13DNA replication_Homo sapiens_hsa030301.86603696
14One carbon pool by folate_Homo sapiens_hsa006701.77387561
15Maturity onset diabetes of the young_Homo sapiens_hsa049501.67775101
16Nucleotide excision repair_Homo sapiens_hsa034201.63598216
17Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.62738967
18Fatty acid metabolism_Homo sapiens_hsa012121.55570536
19Sulfur metabolism_Homo sapiens_hsa009201.54192170
20Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.53751154
21Spliceosome_Homo sapiens_hsa030401.53122491
22Base excision repair_Homo sapiens_hsa034101.50098658
23Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.46332096
24Pyrimidine metabolism_Homo sapiens_hsa002401.44370629
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.44221430
26Arachidonic acid metabolism_Homo sapiens_hsa005901.42717588
27Homologous recombination_Homo sapiens_hsa034401.36064046
28Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.35529652
29Legionellosis_Homo sapiens_hsa051341.32103458
30RNA transport_Homo sapiens_hsa030131.30784070
31Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.29254835
32Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.27413875
33Basal transcription factors_Homo sapiens_hsa030221.25607719
34Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.25454070
35Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.18079736
36Caffeine metabolism_Homo sapiens_hsa002321.12462860
37Fatty acid degradation_Homo sapiens_hsa000711.11772119
38Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.09930170
39Fructose and mannose metabolism_Homo sapiens_hsa000511.07105090
40Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.06511079
41Collecting duct acid secretion_Homo sapiens_hsa049661.05582221
42Linoleic acid metabolism_Homo sapiens_hsa005911.04139339
43Histidine metabolism_Homo sapiens_hsa003401.02423478
44Biosynthesis of amino acids_Homo sapiens_hsa012301.01811759
45Regulation of autophagy_Homo sapiens_hsa041401.00952267
46Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.99114730
47Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.97664484
482-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.96799560
49Sulfur relay system_Homo sapiens_hsa041220.96664815
50Cell cycle_Homo sapiens_hsa041100.94007700
51alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.92689789
52Pentose phosphate pathway_Homo sapiens_hsa000300.91584332
53Carbon metabolism_Homo sapiens_hsa012000.90841809
54Oocyte meiosis_Homo sapiens_hsa041140.90615965
55Primary bile acid biosynthesis_Homo sapiens_hsa001200.88391710
56Selenocompound metabolism_Homo sapiens_hsa004500.86898642
57Fat digestion and absorption_Homo sapiens_hsa049750.86888086
58Primary immunodeficiency_Homo sapiens_hsa053400.84001805
59p53 signaling pathway_Homo sapiens_hsa041150.83918871
60Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.83045444
61Huntingtons disease_Homo sapiens_hsa050160.81106367
62RNA degradation_Homo sapiens_hsa030180.80203609
63N-Glycan biosynthesis_Homo sapiens_hsa005100.79576090
64Antigen processing and presentation_Homo sapiens_hsa046120.78985803
65Pyruvate metabolism_Homo sapiens_hsa006200.76713894
66Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.75552725
67Epstein-Barr virus infection_Homo sapiens_hsa051690.74736485
68Pentose and glucuronate interconversions_Homo sapiens_hsa000400.74539471
69Other glycan degradation_Homo sapiens_hsa005110.74200373
70Purine metabolism_Homo sapiens_hsa002300.73921345
71Glutathione metabolism_Homo sapiens_hsa004800.73441779
72Thyroid cancer_Homo sapiens_hsa052160.71398128
73Drug metabolism - other enzymes_Homo sapiens_hsa009830.70913932
74NF-kappa B signaling pathway_Homo sapiens_hsa040640.70876250
75Galactose metabolism_Homo sapiens_hsa000520.67579491
76Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.65465914
77Herpes simplex infection_Homo sapiens_hsa051680.65301351
78Steroid biosynthesis_Homo sapiens_hsa001000.65029920
79Arginine and proline metabolism_Homo sapiens_hsa003300.64116462
80Peroxisome_Homo sapiens_hsa041460.63802894
81Systemic lupus erythematosus_Homo sapiens_hsa053220.63410457
82Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.63059566
83Fatty acid biosynthesis_Homo sapiens_hsa000610.62676375
84Intestinal immune network for IgA production_Homo sapiens_hsa046720.62514885
85TGF-beta signaling pathway_Homo sapiens_hsa043500.62101759
86Circadian rhythm_Homo sapiens_hsa047100.61222824
87Rheumatoid arthritis_Homo sapiens_hsa053230.60785231
88Tyrosine metabolism_Homo sapiens_hsa003500.60082570
89Steroid hormone biosynthesis_Homo sapiens_hsa001400.60074011
90Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.59648605
91Fanconi anemia pathway_Homo sapiens_hsa034600.59595499
92Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.59543745
93Dorso-ventral axis formation_Homo sapiens_hsa043200.57984036
94Sphingolipid metabolism_Homo sapiens_hsa006000.57320652
95Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.57110117
96Tryptophan metabolism_Homo sapiens_hsa003800.56003360
97Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.53643491
98Phototransduction_Homo sapiens_hsa047440.53143869
99Metabolic pathways_Homo sapiens_hsa011000.52848160
100Cysteine and methionine metabolism_Homo sapiens_hsa002700.51368562
101Fatty acid elongation_Homo sapiens_hsa000620.50975917
102Retinol metabolism_Homo sapiens_hsa008300.50262096
103NOD-like receptor signaling pathway_Homo sapiens_hsa046210.50177523
104Propanoate metabolism_Homo sapiens_hsa006400.50174432
105Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.49502376
106Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.49032861
107beta-Alanine metabolism_Homo sapiens_hsa004100.46639029
108Measles_Homo sapiens_hsa051620.45962497
109Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.45512812
110Alzheimers disease_Homo sapiens_hsa050100.45116565
111Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.45027109
112Leishmaniasis_Homo sapiens_hsa051400.44500798
113Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.43639752
114Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.43215537
115SNARE interactions in vesicular transport_Homo sapiens_hsa041300.42460352
116Adherens junction_Homo sapiens_hsa045200.42027225
117Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.41758085
118Starch and sucrose metabolism_Homo sapiens_hsa005000.41153231
119Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.41144940
120Oxidative phosphorylation_Homo sapiens_hsa001900.40028461
121Parkinsons disease_Homo sapiens_hsa050120.39605504
122Apoptosis_Homo sapiens_hsa042100.39557974
123Viral carcinogenesis_Homo sapiens_hsa052030.38805333
124Protein digestion and absorption_Homo sapiens_hsa049740.38721153
125Asthma_Homo sapiens_hsa053100.38494240
126Hematopoietic cell lineage_Homo sapiens_hsa046400.37556320
127mRNA surveillance pathway_Homo sapiens_hsa030150.36920646
128Nitrogen metabolism_Homo sapiens_hsa009100.36899699
129Phenylalanine metabolism_Homo sapiens_hsa003600.36848802
130Ether lipid metabolism_Homo sapiens_hsa005650.34028735
131Vitamin digestion and absorption_Homo sapiens_hsa049770.32141086
132Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.26506611
133Alcoholism_Homo sapiens_hsa050340.26243593
134Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.26187702
135Chemical carcinogenesis_Homo sapiens_hsa052040.24721497

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