FAM117B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA double-strand break processing (GO:0000729)4.76103189
2layer formation in cerebral cortex (GO:0021819)4.43909993
3negative regulation of DNA-dependent DNA replication (GO:2000104)4.35451470
4negative regulation of translation, ncRNA-mediated (GO:0040033)4.34618704
5regulation of translation, ncRNA-mediated (GO:0045974)4.34618704
6negative regulation of translation involved in gene silencing by miRNA (GO:0035278)4.34618704
7locomotory exploration behavior (GO:0035641)4.26831857
8neuron cell-cell adhesion (GO:0007158)4.09150325
9regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.06661096
10synaptic vesicle maturation (GO:0016188)4.05025922
11regulation of short-term neuronal synaptic plasticity (GO:0048172)3.98050771
12positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.97956447
13regulation of meiosis I (GO:0060631)3.97650979
14positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.93343816
15neural tube formation (GO:0001841)3.90088766
16dendritic spine morphogenesis (GO:0060997)3.88598442
17limb bud formation (GO:0060174)3.80215089
18vocalization behavior (GO:0071625)3.77736704
19regulation of nuclear cell cycle DNA replication (GO:0033262)3.77341375
20nucleobase catabolic process (GO:0046113)3.68464073
21regulation of synaptic vesicle exocytosis (GO:2000300)3.60754567
22synaptic vesicle exocytosis (GO:0016079)3.59031874
23regulation of glutamate receptor signaling pathway (GO:1900449)3.56749244
24kidney morphogenesis (GO:0060993)3.41347957
25protein localization to synapse (GO:0035418)3.40651024
26RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.38922238
27dendrite morphogenesis (GO:0048813)3.37426063
28exploration behavior (GO:0035640)3.35348888
29histone H2A acetylation (GO:0043968)3.30213281
30ionotropic glutamate receptor signaling pathway (GO:0035235)3.28815428
31neuron recognition (GO:0008038)3.25444583
32mitotic sister chromatid cohesion (GO:0007064)3.25366382
33regulation of telomere maintenance (GO:0032204)3.25034329
34olfactory bulb development (GO:0021772)3.20615663
35retinal cone cell development (GO:0046549)3.18411217
36cell migration in hindbrain (GO:0021535)3.14551995
37replication fork processing (GO:0031297)3.14308691
38chromatin remodeling at centromere (GO:0031055)3.13501749
39clathrin coat assembly (GO:0048268)3.12319072
40regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.10678227
41negative regulation of DNA recombination (GO:0045910)3.09211747
42presynaptic membrane assembly (GO:0097105)3.07232006
43synaptic vesicle docking involved in exocytosis (GO:0016081)3.07092498
44regulation of mitotic spindle checkpoint (GO:1903504)3.05522646
45regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.05522646
46regulation of synapse structural plasticity (GO:0051823)3.04826506
47regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.02410382
48negative regulation of cell killing (GO:0031342)3.02397835
49negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.02397835
50sympathetic nervous system development (GO:0048485)3.02012857
51glutamate secretion (GO:0014047)3.00358294
52histone exchange (GO:0043486)2.98122503
53regulation of synaptic vesicle transport (GO:1902803)2.97354319
54cytoplasmic mRNA processing body assembly (GO:0033962)2.96679081
55nerve growth factor signaling pathway (GO:0038180)2.96216393
56glutamate receptor signaling pathway (GO:0007215)2.95884569
57G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.95196031
58proline transport (GO:0015824)2.95122076
59regulation of collateral sprouting (GO:0048670)2.95063382
60somite development (GO:0061053)2.93490935
61regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.92428873
62regulation of helicase activity (GO:0051095)2.92326471
63resolution of meiotic recombination intermediates (GO:0000712)2.90746391
64axonal fasciculation (GO:0007413)2.89501592
65regulation of long-term neuronal synaptic plasticity (GO:0048169)2.88989500
66synapsis (GO:0007129)2.88912486
67behavioral response to ethanol (GO:0048149)2.87008745
68DNA damage response, detection of DNA damage (GO:0042769)2.86798222
69maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.85824209
70central nervous system projection neuron axonogenesis (GO:0021952)2.83913298
71regulation of ARF protein signal transduction (GO:0032012)2.83877082
72response to pheromone (GO:0019236)2.83772768
73regulation of dendritic spine morphogenesis (GO:0061001)2.82836060
74regulation of timing of cell differentiation (GO:0048505)2.82129091
75fucose catabolic process (GO:0019317)2.80307847
76L-fucose metabolic process (GO:0042354)2.80307847
77L-fucose catabolic process (GO:0042355)2.80307847
78regulation of neuronal synaptic plasticity (GO:0048168)2.79460620
79CENP-A containing nucleosome assembly (GO:0034080)2.78816055
80presynaptic membrane organization (GO:0097090)2.78449441
81inositol phosphate catabolic process (GO:0071545)2.78348609
82long-term memory (GO:0007616)2.77709362
83somatic hypermutation of immunoglobulin genes (GO:0016446)2.77642012
84somatic diversification of immune receptors via somatic mutation (GO:0002566)2.77642012
85cullin deneddylation (GO:0010388)2.77260368
86synaptic transmission, glutamatergic (GO:0035249)2.76503509
87exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.76388121
88positive regulation of membrane potential (GO:0045838)2.73949887
89histone mRNA metabolic process (GO:0008334)2.72626587
90histone mRNA catabolic process (GO:0071044)2.71821792
91regulation of Rap GTPase activity (GO:0032317)2.71492871
92regulation of development, heterochronic (GO:0040034)2.70186232
93vesicle transport along microtubule (GO:0047496)2.68660384
94intraciliary transport (GO:0042073)2.68613892
95nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.68492489
96retinal ganglion cell axon guidance (GO:0031290)2.68357266
97postsynaptic membrane organization (GO:0001941)2.67777580
98positive regulation of Rap GTPase activity (GO:0032854)2.66210184
99neurotransmitter secretion (GO:0007269)2.65986495
100regulation of excitatory postsynaptic membrane potential (GO:0060079)2.65604833
101intra-S DNA damage checkpoint (GO:0031573)2.64654074
102somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.62573528
103somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.62573528
104isotype switching (GO:0045190)2.62573528
105negative regulation of microtubule polymerization (GO:0031115)2.61947094
106regulation of postsynaptic membrane potential (GO:0060078)2.61896936
107microtubule depolymerization (GO:0007019)2.60657084
108regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.60584091
109establishment of nucleus localization (GO:0040023)2.60174426
110DNA catabolic process, exonucleolytic (GO:0000738)2.59572659
111synaptic vesicle endocytosis (GO:0048488)2.58082524
112neuron-neuron synaptic transmission (GO:0007270)2.57092447
113negative regulation of telomere maintenance (GO:0032205)2.55895160
114activation of protein kinase A activity (GO:0034199)2.55567793
115telomere maintenance via telomerase (GO:0007004)2.55567489
116cerebellar Purkinje cell differentiation (GO:0021702)2.54091563
117double-strand break repair via homologous recombination (GO:0000724)2.52936438
118negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.52790109
119recombinational repair (GO:0000725)2.52723489
120organelle transport along microtubule (GO:0072384)2.52653320
121activated T cell proliferation (GO:0050798)2.51248508
122protein prenylation (GO:0018342)2.51232638
123prenylation (GO:0097354)2.51232638
124adenosine receptor signaling pathway (GO:0001973)2.50803487
125synapse assembly (GO:0007416)2.50603498
126DNA replication-dependent nucleosome organization (GO:0034723)2.49491950
127DNA replication-dependent nucleosome assembly (GO:0006335)2.49491950
128transmission of nerve impulse (GO:0019226)2.48969444
129sister chromatid cohesion (GO:0007062)2.48506905
130positive regulation of dendritic spine morphogenesis (GO:0061003)2.48412270
131G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.48323074
132regulation of dendritic spine development (GO:0060998)2.47554237
133negative regulation of dendrite development (GO:2000171)2.47506357
134regulation of Rac protein signal transduction (GO:0035020)2.46889710
135positive regulation of mRNA processing (GO:0050685)2.43768707
136neuromuscular process controlling balance (GO:0050885)2.43735256
137microtubule anchoring (GO:0034453)2.42733200
138hindbrain development (GO:0030902)2.41850876
139neuronal action potential propagation (GO:0019227)2.41677656
140glial cell proliferation (GO:0014009)2.41322503
141neurotransmitter-gated ion channel clustering (GO:0072578)2.41249694
142regulation of neurotransmitter secretion (GO:0046928)2.41188392
143regulation of cAMP-dependent protein kinase activity (GO:2000479)2.40995996
144acrosome assembly (GO:0001675)2.40697721
145single strand break repair (GO:0000012)2.40555421
146centriole replication (GO:0007099)2.39953929
147protein K11-linked deubiquitination (GO:0035871)2.39154546
148regulation of synaptic transmission, glutamatergic (GO:0051966)2.38401080
149axon extension (GO:0048675)2.38308289
150positive regulation of filopodium assembly (GO:0051491)2.38228739
151kinetochore assembly (GO:0051382)2.37554213
152regulation of telomere maintenance via telomerase (GO:0032210)2.36602689
153pyrimidine nucleobase catabolic process (GO:0006208)2.36601247
154reciprocal DNA recombination (GO:0035825)2.35682890
155reciprocal meiotic recombination (GO:0007131)2.35682890
156piRNA metabolic process (GO:0034587)2.35159174
157startle response (GO:0001964)2.34901437
158gamma-aminobutyric acid signaling pathway (GO:0007214)2.34786674
159DNA replication-independent nucleosome assembly (GO:0006336)2.34730797
160DNA replication-independent nucleosome organization (GO:0034724)2.34730797
161dendritic spine organization (GO:0097061)2.34490583
162protein deneddylation (GO:0000338)2.33903068
163pre-miRNA processing (GO:0031054)2.33175428
164spinal cord development (GO:0021510)2.31691759
165auditory behavior (GO:0031223)2.31627980
166regulation of synaptic plasticity (GO:0048167)2.30079344
167behavioral response to nicotine (GO:0035095)2.29871791
168central nervous system neuron axonogenesis (GO:0021955)2.29685230
169cerebral cortex cell migration (GO:0021795)2.29615362
170positive regulation of synapse maturation (GO:0090129)2.28570317
171SMAD protein complex assembly (GO:0007183)2.28484172
172cerebellar granule cell differentiation (GO:0021707)2.28120705
173regulation of vesicle fusion (GO:0031338)2.27709792
174cellular response to nerve growth factor stimulus (GO:1990090)2.26871208
175response to nerve growth factor (GO:1990089)2.26871208
176cerebral cortex radially oriented cell migration (GO:0021799)2.26813197
177prepulse inhibition (GO:0060134)2.26449110
178regulation of respiratory system process (GO:0044065)2.26094737
179response to histamine (GO:0034776)2.25913717
180regulation of clathrin-mediated endocytosis (GO:2000369)2.25784656
181membrane depolarization (GO:0051899)2.25690383
182synapse organization (GO:0050808)2.25631643
183long-term synaptic potentiation (GO:0060291)2.25612234
184innervation (GO:0060384)2.25529487
185protein targeting to Golgi (GO:0000042)2.23993160
186sodium ion export (GO:0071436)2.23296158
187cellular potassium ion homeostasis (GO:0030007)2.22620893
188regulation of neuron migration (GO:2001222)2.22326255
189positive regulation of synaptic transmission, GABAergic (GO:0032230)2.22285836

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.12514929
2GBX2_23144817_ChIP-Seq_PC3_Human2.79893199
3VDR_22108803_ChIP-Seq_LS180_Human2.75133238
4GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.69542857
5EWS_26573619_Chip-Seq_HEK293_Human2.44559928
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.37183468
7MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.30457635
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.23184758
9* FLI1_27457419_Chip-Seq_LIVER_Mouse2.19722326
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.17315647
11SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.17132604
12SMAD_19615063_ChIP-ChIP_OVARY_Human2.08509969
13RNF2_18974828_ChIP-Seq_MESCs_Mouse2.02672862
14EZH2_18974828_ChIP-Seq_MESCs_Mouse2.02672862
15EZH2_27304074_Chip-Seq_ESCs_Mouse1.99555769
16DROSHA_22980978_ChIP-Seq_HELA_Human1.97392974
17TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.96410089
18SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.93460625
19REST_21632747_ChIP-Seq_MESCs_Mouse1.93457008
20AR_21572438_ChIP-Seq_LNCaP_Human1.92124270
21RNF2_27304074_Chip-Seq_ESCs_Mouse1.90340838
22MTF2_20144788_ChIP-Seq_MESCs_Mouse1.86248603
23HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.85610146
24SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.83784045
25SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.82665673
26E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.79387345
27JARID2_20075857_ChIP-Seq_MESCs_Mouse1.77297422
28KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.77230302
29SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.76460306
30RBPJ_22232070_ChIP-Seq_NCS_Mouse1.76141292
31RARB_27405468_Chip-Seq_BRAIN_Mouse1.74507736
32CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.74201317
33SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.74090268
34E2F4_17652178_ChIP-ChIP_JURKAT_Human1.73696269
35ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.73625167
36* PCGF2_27294783_Chip-Seq_ESCs_Mouse1.73171330
37EST1_17652178_ChIP-ChIP_JURKAT_Human1.71820420
38POU5F1_16153702_ChIP-ChIP_HESCs_Human1.71092523
39* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.69918503
40EZH2_27294783_Chip-Seq_ESCs_Mouse1.68796066
41TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.68731251
42ZNF217_24962896_ChIP-Seq_MCF-7_Human1.67567408
43SUZ12_27294783_Chip-Seq_ESCs_Mouse1.63492301
44HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.63392187
45SMAD4_21799915_ChIP-Seq_A2780_Human1.61987098
46PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.61384179
47VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.59548048
48CTBP2_25329375_ChIP-Seq_LNCAP_Human1.57777944
49BCAT_22108803_ChIP-Seq_LS180_Human1.53499230
50NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.53227819
51AHR_22903824_ChIP-Seq_MCF-7_Human1.51276831
52TAF15_26573619_Chip-Seq_HEK293_Human1.47455644
53ARNT_22903824_ChIP-Seq_MCF-7_Human1.46787990
54MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.46308032
55EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.45272700
56ELK1_19687146_ChIP-ChIP_HELA_Human1.44292260
57IKZF1_21737484_ChIP-ChIP_HCT116_Human1.42225075
58CDX2_19796622_ChIP-Seq_MESCs_Mouse1.41770717
59KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.41529893
60GABP_17652178_ChIP-ChIP_JURKAT_Human1.41358046
61NOTCH1_21737748_ChIP-Seq_TLL_Human1.40092197
62ZFP57_27257070_Chip-Seq_ESCs_Mouse1.39469998
63ER_23166858_ChIP-Seq_MCF-7_Human1.39310826
64* EZH2_27294783_Chip-Seq_NPCs_Mouse1.39213788
65BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.38606350
66REST_18959480_ChIP-ChIP_MESCs_Mouse1.38095595
67P300_19829295_ChIP-Seq_ESCs_Human1.38063477
68OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37996544
69SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36483867
70EED_16625203_ChIP-ChIP_MESCs_Mouse1.35788376
71PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.35679551
72IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.35341303
73CBP_20019798_ChIP-Seq_JUKART_Human1.35341303
74CTBP1_25329375_ChIP-Seq_LNCAP_Human1.35229815
75STAT3_23295773_ChIP-Seq_U87_Human1.34804001
76* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.34061302
77* PCGF2_27294783_Chip-Seq_NPCs_Mouse1.33435770
78POU3F2_20337985_ChIP-ChIP_501MEL_Human1.32703212
79SMAD3_21741376_ChIP-Seq_EPCs_Human1.31333728
80GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.30663448
81TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30265335
82POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.30265335
83* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.30252065
84SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28984361
85SOX2_21211035_ChIP-Seq_LN229_Gbm1.28388480
86FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.27689631
87SALL1_21062744_ChIP-ChIP_HESCs_Human1.26432398
88WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.25485634
89PIAS1_25552417_ChIP-Seq_VCAP_Human1.24855500
90CBX2_27304074_Chip-Seq_ESCs_Mouse1.23899713
91WT1_25993318_ChIP-Seq_PODOCYTE_Human1.23774252
92AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.23679265
93* NANOG_18555785_Chip-Seq_ESCs_Mouse1.22948812
94IGF1R_20145208_ChIP-Seq_DFB_Human1.22900581
95RNF2_27304074_Chip-Seq_NSC_Mouse1.22606023
96TOP2B_26459242_ChIP-Seq_MCF-7_Human1.22537191
97CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.22228867
98YAP1_20516196_ChIP-Seq_MESCs_Mouse1.21856395
99KLF5_20875108_ChIP-Seq_MESCs_Mouse1.21343840
100KDM2B_26808549_Chip-Seq_K562_Human1.20724827
101TCF4_22108803_ChIP-Seq_LS180_Human1.19603089
102AR_19668381_ChIP-Seq_PC3_Human1.18267069
103* NFE2_27457419_Chip-Seq_LIVER_Mouse1.17835449
104STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.17725000
105AR_25329375_ChIP-Seq_VCAP_Human1.16474069
106TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.16188605
107RING1B_27294783_Chip-Seq_NPCs_Mouse1.15957166
108* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.15888265
109* TCF4_23295773_ChIP-Seq_U87_Human1.15803195
110FLI1_21867929_ChIP-Seq_TH2_Mouse1.14995762
111TP53_16413492_ChIP-PET_HCT116_Human1.14372037
112P53_22127205_ChIP-Seq_FIBROBLAST_Human1.14355904
113EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.13830938
114RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.13056747
115MYC_18940864_ChIP-ChIP_HL60_Human1.11354216
116* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.10788613
117NANOG_19829295_ChIP-Seq_ESCs_Human1.10576986
118SOX2_19829295_ChIP-Seq_ESCs_Human1.10576986
119STAT6_21828071_ChIP-Seq_BEAS2B_Human1.09414572
120TP63_19390658_ChIP-ChIP_HaCaT_Human1.08894659
121SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.08739457
122ZNF274_21170338_ChIP-Seq_K562_Hela1.08376443
123FUS_26573619_Chip-Seq_HEK293_Human1.08150864
124BMI1_23680149_ChIP-Seq_NPCS_Mouse1.07773854
125NR3C1_21868756_ChIP-Seq_MCF10A_Human1.07723661
126IRF1_19129219_ChIP-ChIP_H3396_Human1.07490397
127* VDR_23849224_ChIP-Seq_CD4+_Human1.06754901
128TP53_22573176_ChIP-Seq_HFKS_Human1.06682174
129MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.06660717
130TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05754066
131RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.05250558
132KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.05043652
133RING1B_27294783_Chip-Seq_ESCs_Mouse1.04220956
134SOX2_16153702_ChIP-ChIP_HESCs_Human1.04126840
135STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.03665308
136CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03320690
137RUNX2_22187159_ChIP-Seq_PCA_Human1.03288847
138PRDM14_20953172_ChIP-Seq_ESCs_Human1.03172121
139SMAD3_21741376_ChIP-Seq_ESCs_Human1.02543119
140WT1_19549856_ChIP-ChIP_CCG9911_Human1.02267070
141FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.01782262
142DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.01357045
143SMAD4_21741376_ChIP-Seq_EPCs_Human1.01267720
144* P53_22387025_ChIP-Seq_ESCs_Mouse1.01182036
145TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.00922345
146* CRX_20693478_ChIP-Seq_RETINA_Mouse1.00803193
147PADI4_21655091_ChIP-ChIP_MCF-7_Human1.00732289
148* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.00598169
149TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.00112426
150TCF4_18268006_ChIP-ChIP_LS174T_Human0.99802025
151PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.97264627
152ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.96585748
153ESR1_20079471_ChIP-ChIP_T-47D_Human0.96513524
154TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.96491577
155UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.94801526

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.07235675
2MP0003880_abnormal_central_pattern3.86897530
3MP0004270_analgesia3.63038137
4MP0003635_abnormal_synaptic_transmissio3.43298785
5MP0005423_abnormal_somatic_nervous3.03411554
6MP0003787_abnormal_imprinting2.89222887
7MP0002063_abnormal_learning/memory/cond2.67964342
8MP0009745_abnormal_behavioral_response2.48144972
9MP0000569_abnormal_digit_pigmentation2.45267326
10MP0000778_abnormal_nervous_system2.44948638
11MP0008058_abnormal_DNA_repair2.39765652
12MP0002064_seizures2.35487518
13MP0002734_abnormal_mechanical_nocicepti2.34232379
14MP0008057_abnormal_DNA_replication2.32454676
15MP0002572_abnormal_emotion/affect_behav2.29439956
16MP0001486_abnormal_startle_reflex2.22498307
17MP0001968_abnormal_touch/_nociception2.20842066
18MP0006292_abnormal_olfactory_placode2.07825769
19MP0009046_muscle_twitch2.03571602
20MP0009780_abnormal_chondrocyte_physiolo2.00333381
21MP0003303_peritoneal_inflammation1.91982194
22MP0002751_abnormal_autonomic_nervous1.90956749
23MP0002733_abnormal_thermal_nociception1.87982501
24MP0001440_abnormal_grooming_behavior1.83708065
25MP0002735_abnormal_chemical_nociception1.75474499
26MP0002272_abnormal_nervous_system1.73979439
27MP0001529_abnormal_vocalization1.72317783
28MP0002184_abnormal_innervation1.70315579
29MP0001970_abnormal_pain_threshold1.68844555
30MP0002938_white_spotting1.66441685
31MP0004811_abnormal_neuron_physiology1.65160579
32MP0010094_abnormal_chromosome_stability1.63791067
33MP0003567_abnormal_fetal_cardiomyocyte1.62608695
34MP0001293_anophthalmia1.61578390
35MP0003718_maternal_effect1.59179613
36MP0002557_abnormal_social/conspecific_i1.56367870
37MP0001501_abnormal_sleep_pattern1.56299938
38MP0002067_abnormal_sensory_capabilities1.55466803
39MP0003119_abnormal_digestive_system1.54178327
40MP0002736_abnormal_nociception_after1.52324052
41MP0005386_behavior/neurological_phenoty1.49487516
42MP0004924_abnormal_behavior1.49487516
43MP0002234_abnormal_pharynx_morphology1.47409360
44MP0000955_abnormal_spinal_cord1.41846765
45MP0004885_abnormal_endolymph1.41357444
46MP0003693_abnormal_embryo_hatching1.38592579
47MP0006276_abnormal_autonomic_nervous1.37966347
48MP0003122_maternal_imprinting1.37355990
49MP0008569_lethality_at_weaning1.35245997
50MP0003121_genomic_imprinting1.33607671
51MP0002882_abnormal_neuron_morphology1.33506226
52MP0002822_catalepsy1.33449091
53MP0005394_taste/olfaction_phenotype1.29496129
54MP0005499_abnormal_olfactory_system1.29496129
55MP0003937_abnormal_limbs/digits/tail_de1.28993279
56MP0003195_calcinosis1.27183960
57MP0004742_abnormal_vestibular_system1.26892861
58MP0010234_abnormal_vibrissa_follicle1.26253990
59MP0001188_hyperpigmentation1.25150801
60MP0002152_abnormal_brain_morphology1.24924655
61MP0005253_abnormal_eye_physiology1.22925150
62MP0004510_myositis1.21920223
63MP0005360_urolithiasis1.20833757
64MP0008877_abnormal_DNA_methylation1.18668877
65MP0004043_abnormal_pH_regulation1.17386036
66MP0008789_abnormal_olfactory_epithelium1.17282667
67MP0004133_heterotaxia1.13074390
68MP0002233_abnormal_nose_morphology1.12467858
69MP0002066_abnormal_motor_capabilities/c1.12448140
70MP0005187_abnormal_penis_morphology1.11651422
71MP0004858_abnormal_nervous_system1.11454518
72MP0005623_abnormal_meninges_morphology1.11394066
73MP0008007_abnormal_cellular_replicative1.11250136
74MP0003941_abnormal_skin_development1.10147659
75MP0001502_abnormal_circadian_rhythm1.06969596
76MP0008872_abnormal_physiological_respon1.04198717
77MP0003861_abnormal_nervous_system1.00884990
78MP0001929_abnormal_gametogenesis1.00450930
79MP0001286_abnormal_eye_development0.99864067
80MP0004484_altered_response_of0.98499605
81MP0003633_abnormal_nervous_system0.97637893
82MP0005409_darkened_coat_color0.97393462
83MP0001879_abnormal_lymphatic_vessel0.97064066
84MP0000537_abnormal_urethra_morphology0.97018182
85MP0001485_abnormal_pinna_reflex0.96973625
86MP0002210_abnormal_sex_determination0.95098130
87MP0000653_abnormal_sex_gland0.95087375
88MP0003300_gastrointestinal_ulcer0.94987302
89MP0003329_amyloid_beta_deposits0.94419370
90MP0002909_abnormal_adrenal_gland0.94214522
91MP0002928_abnormal_bile_duct0.94083469
92MP0005167_abnormal_blood-brain_barrier0.93723398
93MP0009703_decreased_birth_body0.93638369
94MP0000538_abnormal_urinary_bladder0.93518393
95MP0008961_abnormal_basal_metabolism0.92825206
96MP0005075_abnormal_melanosome_morpholog0.92558591
97MP0003111_abnormal_nucleus_morphology0.91779402
98MP0003631_nervous_system_phenotype0.90097640
99MP0003698_abnormal_male_reproductive0.89485888
100MP0001851_eye_inflammation0.89402292
101MP0001145_abnormal_male_reproductive0.88614258
102MP0005084_abnormal_gallbladder_morpholo0.88049181
103MP0000920_abnormal_myelination0.87846230
104MP0004883_abnormal_blood_vessel0.87788024
105MP0008995_early_reproductive_senescence0.86492661
106MP0005645_abnormal_hypothalamus_physiol0.86238755
107MP0000647_abnormal_sebaceous_gland0.85601071
108MP0004957_abnormal_blastocyst_morpholog0.85437631
109MP0006035_abnormal_mitochondrial_morpho0.85239638
110MP0000427_abnormal_hair_cycle0.84589292
111MP0003634_abnormal_glial_cell0.84016295
112MP0008932_abnormal_embryonic_tissue0.83423526
113MP0006072_abnormal_retinal_apoptosis0.82100250
114MP0000534_abnormal_ureter_morphology0.81686634
115MP0003755_abnormal_palate_morphology0.81641842
116MP0002837_dystrophic_cardiac_calcinosis0.80367143
117MP0004215_abnormal_myocardial_fiber0.79856316
118MP0003690_abnormal_glial_cell0.79795748
119MP0005195_abnormal_posterior_eye0.79764593
120MP0005367_renal/urinary_system_phenotyp0.79716038
121MP0000516_abnormal_urinary_system0.79716038
122MP0001299_abnormal_eye_distance/0.79638488
123MP0003632_abnormal_nervous_system0.78787714
124MP0003943_abnormal_hepatobiliary_system0.78684101
125MP0002638_abnormal_pupillary_reflex0.78299886
126MP0001348_abnormal_lacrimal_gland0.78061269
127MP0005310_abnormal_salivary_gland0.77415090
128MP0004085_abnormal_heartbeat0.75316485
129MP0008874_decreased_physiological_sensi0.74883015
130MP0001177_atelectasis0.72883159
131MP0000631_abnormal_neuroendocrine_gland0.72264750
132MP0001963_abnormal_hearing_physiology0.72086044
133MP0001943_abnormal_respiration0.71382423
134MP0003045_fibrosis0.70795772
135MP0003091_abnormal_cell_migration0.70758102
136MP0002229_neurodegeneration0.70032109
137MP0001905_abnormal_dopamine_level0.69421820
138MP0002752_abnormal_somatic_nervous0.69255036
139MP0001984_abnormal_olfaction0.67778925
140MP0003890_abnormal_embryonic-extraembry0.67055241
141MP0004185_abnormal_adipocyte_glucose0.65927568
142MP0002069_abnormal_eating/drinking_beha0.65460230
143MP0003385_abnormal_body_wall0.64796117
144MP0003879_abnormal_hair_cell0.64365344
145MP0005076_abnormal_cell_differentiation0.62512288
146MP0002081_perinatal_lethality0.61788115
147MP0005646_abnormal_pituitary_gland0.60175668
148MP0003123_paternal_imprinting0.59282007
149MP0005551_abnormal_eye_electrophysiolog0.56551109
150MP0002102_abnormal_ear_morphology0.56361631

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the labia minora (HP:0012880)4.24809874
2Focal motor seizures (HP:0011153)3.99164047
3Focal seizures (HP:0007359)3.44920481
4Papilledema (HP:0001085)3.43180961
5Atonic seizures (HP:0010819)3.41666427
6Myokymia (HP:0002411)3.41239660
7Colon cancer (HP:0003003)3.29485609
8Epileptic encephalopathy (HP:0200134)3.29283908
9Progressive cerebellar ataxia (HP:0002073)3.22269500
10Mutism (HP:0002300)3.19100986
11Pancreatic cysts (HP:0001737)3.12741034
12Febrile seizures (HP:0002373)3.04764142
13Pancreatic fibrosis (HP:0100732)2.96981955
14Broad-based gait (HP:0002136)2.93533081
15Intestinal atresia (HP:0011100)2.88381408
16True hermaphroditism (HP:0010459)2.80830263
17Drooling (HP:0002307)2.79310790
18Excessive salivation (HP:0003781)2.79310790
19Supranuclear gaze palsy (HP:0000605)2.79070097
20Hypothermia (HP:0002045)2.76779117
21Visual hallucinations (HP:0002367)2.76775995
22Insidious onset (HP:0003587)2.74516771
23Termporal pattern (HP:0011008)2.74516771
24Ependymoma (HP:0002888)2.69609331
25Nephronophthisis (HP:0000090)2.66438940
26Action tremor (HP:0002345)2.65855062
27Inappropriate behavior (HP:0000719)2.65246383
28Abnormality of the corticospinal tract (HP:0002492)2.62433780
29Abnormality of midbrain morphology (HP:0002418)2.61894987
30Molar tooth sign on MRI (HP:0002419)2.61894987
31Lower limb asymmetry (HP:0100559)2.60425862
32Papillary thyroid carcinoma (HP:0002895)2.60391273
33Glioma (HP:0009733)2.57809760
34Neoplasm of the adrenal cortex (HP:0100641)2.52206777
35Truncal ataxia (HP:0002078)2.48178494
36Genetic anticipation (HP:0003743)2.47179948
37Urinary bladder sphincter dysfunction (HP:0002839)2.46439949
38Astrocytoma (HP:0009592)2.45777634
39Diplopia (HP:0000651)2.45641779
40Abnormality of binocular vision (HP:0011514)2.45641779
41Obstructive sleep apnea (HP:0002870)2.40138134
42Abnormality of chromosome stability (HP:0003220)2.39969571
43Ankle clonus (HP:0011448)2.38234257
44Lissencephaly (HP:0001339)2.36426125
45Amyotrophic lateral sclerosis (HP:0007354)2.35387042
46Abolished electroretinogram (ERG) (HP:0000550)2.29625318
47Absence seizures (HP:0002121)2.29567071
48Abnormal lung lobation (HP:0002101)2.29230117
49Widely spaced teeth (HP:0000687)2.28455684
50Medial flaring of the eyebrow (HP:0010747)2.25250297
51Aqueductal stenosis (HP:0002410)2.22766826
52Abnormality of the renal medulla (HP:0100957)2.21587041
53Methylmalonic acidemia (HP:0002912)2.20886571
54Macroorchidism (HP:0000053)2.20653864
55Progressive inability to walk (HP:0002505)2.19381098
56Urinary urgency (HP:0000012)2.18946622
57Aplasia/Hypoplasia of the uvula (HP:0010293)2.18483921
58Meckel diverticulum (HP:0002245)2.18320946
59Stereotypic behavior (HP:0000733)2.18077304
60Gonadotropin excess (HP:0000837)2.16295644
61Abnormality of the ileum (HP:0001549)2.16241837
62Absent speech (HP:0001344)2.16004839
63Hepatoblastoma (HP:0002884)2.15726080
64Impaired vibration sensation in the lower limbs (HP:0002166)2.15532453
65Gaze-evoked nystagmus (HP:0000640)2.15224189
66Genital tract atresia (HP:0001827)2.13223278
67Agitation (HP:0000713)2.12663446
68Exotropia (HP:0000577)2.11367758
69Medulloblastoma (HP:0002885)2.11294923
70Neoplasm of the oral cavity (HP:0100649)2.08855663
71Abnormality of the renal cortex (HP:0011035)2.08138809
72Renal cortical cysts (HP:0000803)2.07484949
73Amblyopia (HP:0000646)2.06347492
74Hyperglycinemia (HP:0002154)2.06294366
75Narrow forehead (HP:0000341)2.04705523
76Cupped ear (HP:0000378)2.03468835
77Abnormality of salivation (HP:0100755)2.02289956
78Rhabdomyosarcoma (HP:0002859)2.01703684
79Dialeptic seizures (HP:0011146)2.01090277
80Oligodactyly (hands) (HP:0001180)2.01081745
81Chronic hepatic failure (HP:0100626)2.00649102
82Limb dystonia (HP:0002451)1.99847964
83Vaginal atresia (HP:0000148)1.99067177
84Hyperventilation (HP:0002883)1.98808916
85Volvulus (HP:0002580)1.98025810
86Renal hypoplasia (HP:0000089)1.96818248
87Apathy (HP:0000741)1.96565109
88Small hand (HP:0200055)1.95888235
89Hematochezia (HP:0002573)1.95702354
90Dandy-Walker malformation (HP:0001305)1.95657276
91Bifid tongue (HP:0010297)1.95164250
92Gait imbalance (HP:0002141)1.94044572
93Abnormal eating behavior (HP:0100738)1.93085195
94Generalized tonic-clonic seizures (HP:0002069)1.92825677
95Scrotal hypoplasia (HP:0000046)1.92652781
96Abnormality of the lower motor neuron (HP:0002366)1.92629221
97Bile duct proliferation (HP:0001408)1.91634975
98Abnormal biliary tract physiology (HP:0012439)1.91634975
99Impaired smooth pursuit (HP:0007772)1.91306481
100Poor eye contact (HP:0000817)1.90759848
101Thyroid carcinoma (HP:0002890)1.90187338
102Arterial tortuosity (HP:0005116)1.89921756
103Lower limb amyotrophy (HP:0007210)1.89874164
104Pachygyria (HP:0001302)1.88600555
105Disinhibition (HP:0000734)1.87740429
106Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.86483524
107Degeneration of the lateral corticospinal tracts (HP:0002314)1.86483524
108Sloping forehead (HP:0000340)1.85875960
109Megalencephaly (HP:0001355)1.84604090
110Spastic gait (HP:0002064)1.84249050
111Nephroblastoma (Wilms tumor) (HP:0002667)1.84243853
112Abnormality of ocular smooth pursuit (HP:0000617)1.84073221
113Transitional cell carcinoma of the bladder (HP:0006740)1.83714542
114Aplasia/Hypoplasia of the sternum (HP:0006714)1.82995736
115Thyroiditis (HP:0100646)1.82035854
116Hemiparesis (HP:0001269)1.81498922
117Congenital stationary night blindness (HP:0007642)1.81377322
118Aplasia/Hypoplasia of the tongue (HP:0010295)1.81111981
119Fetal akinesia sequence (HP:0001989)1.80882051
120Dysmetria (HP:0001310)1.80868154
121Anencephaly (HP:0002323)1.80618406
122Supernumerary spleens (HP:0009799)1.80617056
123Depression (HP:0000716)1.80488283
124Protruding tongue (HP:0010808)1.80143390
125Neoplasm of the adrenal gland (HP:0100631)1.79293805
126Subacute progressive viral hepatitis (HP:0006572)1.79200710
127Sporadic (HP:0003745)1.78994069
128Embryonal renal neoplasm (HP:0011794)1.77612707
129Postaxial hand polydactyly (HP:0001162)1.77013321
130Abnormality of the duodenum (HP:0002246)1.76880078
131Methylmalonic aciduria (HP:0012120)1.76628516
132Gastroesophageal reflux (HP:0002020)1.76463653
133Gastrointestinal atresia (HP:0002589)1.76408317
134Optic nerve hypoplasia (HP:0000609)1.76129163
135Septo-optic dysplasia (HP:0100842)1.75705788
136Nephrogenic diabetes insipidus (HP:0009806)1.75469786
137Congenital primary aphakia (HP:0007707)1.75180046
138Cystic liver disease (HP:0006706)1.75012961
139Bilateral microphthalmos (HP:0007633)1.74574297
140Urethral obstruction (HP:0000796)1.74443002
141Type II lissencephaly (HP:0007260)1.73136083
142Sclerocornea (HP:0000647)1.73101917
143Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.72766565
144Pointed chin (HP:0000307)1.72117286
145Postaxial foot polydactyly (HP:0001830)1.71995553
146Stomach cancer (HP:0012126)1.71440468
147Polyphagia (HP:0002591)1.70897996
148Preaxial hand polydactyly (HP:0001177)1.70632306
149Abnormality of the metopic suture (HP:0005556)1.70551233
150Pancreatic islet-cell hyperplasia (HP:0004510)1.70286413
151Abnormality of the preputium (HP:0100587)1.69191442
152Bladder carcinoma (HP:0002862)1.69189401
153Bladder neoplasm (HP:0009725)1.69189401
154Hyperglycinuria (HP:0003108)1.69072864
155Cortical dysplasia (HP:0002539)1.68990470
156Cerebral inclusion bodies (HP:0100314)1.68781777
157Hyperthyroidism (HP:0000836)1.68662004
158Duodenal stenosis (HP:0100867)1.68119858
159Small intestinal stenosis (HP:0012848)1.68119858
160Neoplasm of striated muscle (HP:0009728)1.67840438
161Biliary tract neoplasm (HP:0100574)1.67819437
162Agnosia (HP:0010524)1.67800880
163Open mouth (HP:0000194)1.67179438
164Sleep apnea (HP:0010535)1.65913563
165Dysmetric saccades (HP:0000641)1.65032231
166Diminished motivation (HP:0000745)1.64879668
167Impaired social interactions (HP:0000735)1.63172075
168Abnormal social behavior (HP:0012433)1.63172075
169Abnormality of the fingertips (HP:0001211)1.62734045
170Midline defect of the nose (HP:0004122)1.62384001
171Inability to walk (HP:0002540)1.62039326
172Hemiplegia (HP:0002301)1.61784719
173Akinesia (HP:0002304)1.61776940
174Autism (HP:0000717)1.61018230
175Vascular tortuosity (HP:0004948)1.61000677
176Trigonocephaly (HP:0000243)1.59662185
177Neurofibrillary tangles (HP:0002185)1.59640402
178Lower limb muscle weakness (HP:0007340)1.59473555
179Abnormal hair whorl (HP:0010721)1.54963618
180Failure to thrive in infancy (HP:0001531)1.54573697
181Sacral dimple (HP:0000960)1.50943266
182Asymmetry of the thorax (HP:0001555)1.50335435
183Abnormality of the astrocytes (HP:0100707)1.50249503

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.76964373
2WNK33.66716764
3MAP3K93.53957279
4MKNK23.09727089
5TRIM283.03999371
6ACVR1B3.00307996
7BMPR1B2.90142102
8NTRK32.83013189
9MAP3K42.71407751
10NTRK22.33144255
11MAP4K22.10683154
12MKNK12.07378365
13NUAK12.03485457
14MAPK132.03318474
15MINK12.01871143
16SIK21.90449382
17MAP3K61.89148309
18EPHA41.88724556
19BCR1.85770020
20CASK1.85671110
21PLK31.76087155
22MAP2K71.74380978
23PNCK1.68238379
24ZAK1.67996438
25PAK61.67003408
26KSR11.61250075
27MAP3K121.60191435
28TYRO31.55184889
29STK111.51777719
30DMPK1.43180648
31MAP2K41.41700874
32KSR21.40632571
33LATS21.39598847
34OXSR11.37721364
35BUB11.37183076
36PLK41.35753670
37CAMK1G1.34683922
38TSSK61.32192583
39TAF11.30159738
40SRPK11.29704143
41FGFR21.26354535
42TGFBR11.24563474
43CDK51.23325809
44PLK21.23008015
45EIF2AK31.19751036
46GRK11.17946444
47DAPK21.17153597
48FES1.14646620
49CSNK1G21.13179420
50RIPK41.11470769
51RET1.11166885
52BRSK21.10476504
53DYRK21.10404086
54WNK41.09050758
55PRPF4B1.09033037
56MAP3K21.08659433
57CAMKK11.07538754
58FRK1.06789069
59STK391.05698725
60TNIK1.05426340
61YES11.05163186
62WEE11.05048096
63TTK1.02597196
64RIPK11.00718392
65CDC71.00386632
66UHMK10.98430554
67DYRK30.96796893
68CDK190.96319732
69PRKD30.95903816
70TAOK10.94913979
71MARK20.94221750
72VRK10.93615361
73STK38L0.92673397
74RAF10.92596212
75NLK0.92420458
76FGR0.91786898
77ADRBK20.90259234
78PDK20.88311924
79BRD40.87518868
80INSRR0.87487448
81NTRK10.85674343
82PLK10.83296355
83PRKCG0.81891925
84GRK50.81502851
85CSNK1A1L0.80658631
86RPS6KA20.79546400
87MAPK120.78947851
88DYRK1A0.78551341
89PRKCH0.77900971
90SGK20.77020709
91WNK10.76537602
92PHKG10.75540531
93PHKG20.75540531
94STK380.75130308
95PAK30.71075736
96PINK10.69739594
97SGK30.69567686
98CSNK1G30.68709866
99PASK0.67516196
100STK30.66695143
101ATM0.66300187
102PDK10.66290699
103FLT30.65559997
104SGK2230.65257153
105SGK4940.65257153
106SGK10.64978905
107ALK0.63540380
108ERBB30.63296661
109PDGFRB0.63079781
110LATS10.63042353
111MST40.62466327
112PRKCE0.61957227
113EIF2AK20.60894044
114CDK180.59636056
115CDK140.59623928
116ATR0.59240428
117TAOK30.58039815
118CDK150.57765068
119CSNK1G10.56907528
120PKN10.56362316
121PDPK10.56057720
122FGFR30.55410327
123CAMKK20.52755765
124FGFR10.52154945
125CDK120.51954994
126CAMK2A0.51707854
127SIK30.51404117
128EPHB20.50482654
129TGFBR20.48991087
130HIPK20.48727723
131MAPK70.47879616
132CAMK40.47805243
133CDK11A0.47346482
134PKN20.46971805
135CDK30.46849287
136CAMK1D0.45127231
137FYN0.45053286
138RPS6KA40.44087342
139ICK0.43551009
140CDK90.43012846
141NEK60.42365461
142PTK2B0.42307648
143AKT30.40852536
144RPS6KA30.38648402
145MAPK100.38599226
146IRAK10.37800652
147PRKCZ0.37743727
148MAPK80.37734854
149ARAF0.37614962
150STK240.37541313
151PRKCQ0.37359058
152CSNK1E0.36928446
153CHEK20.35199933
154CSNK1D0.34787038
155STK160.34641901
156PRKDC0.33314474
157IRAK20.31445925
158ADRBK10.27571741
159PRKG10.25478508

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034503.29019294
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.85800498
3Propanoate metabolism_Homo sapiens_hsa006402.82365597
4Protein export_Homo sapiens_hsa030602.75138673
5Basal transcription factors_Homo sapiens_hsa030222.59327298
6Steroid biosynthesis_Homo sapiens_hsa001002.40018080
7RNA degradation_Homo sapiens_hsa030182.23208707
8Fanconi anemia pathway_Homo sapiens_hsa034602.18034586
9Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.16893736
10Nicotine addiction_Homo sapiens_hsa050332.15411584
11Homologous recombination_Homo sapiens_hsa034402.10455719
12Mismatch repair_Homo sapiens_hsa034301.97832522
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.92969448
14Butanoate metabolism_Homo sapiens_hsa006501.91999815
15RNA polymerase_Homo sapiens_hsa030201.91432889
16Long-term potentiation_Homo sapiens_hsa047201.90335510
17Glutamatergic synapse_Homo sapiens_hsa047241.78411784
18Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.74358109
19Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.71781740
20Circadian entrainment_Homo sapiens_hsa047131.69456658
21Morphine addiction_Homo sapiens_hsa050321.68448406
22Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.66265861
23Synaptic vesicle cycle_Homo sapiens_hsa047211.63465440
24Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.61590241
25RNA transport_Homo sapiens_hsa030131.60982067
26Olfactory transduction_Homo sapiens_hsa047401.60626865
27Dorso-ventral axis formation_Homo sapiens_hsa043201.57463260
28Dopaminergic synapse_Homo sapiens_hsa047281.57396911
29GABAergic synapse_Homo sapiens_hsa047271.50029535
30Axon guidance_Homo sapiens_hsa043601.49801145
31Cholinergic synapse_Homo sapiens_hsa047251.48634652
32Amphetamine addiction_Homo sapiens_hsa050311.48070358
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.45118186
34Long-term depression_Homo sapiens_hsa047301.43480993
35Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.42514698
36Renin secretion_Homo sapiens_hsa049241.41712262
37Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.41664336
38Salivary secretion_Homo sapiens_hsa049701.40265099
39Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.37272233
40Serotonergic synapse_Homo sapiens_hsa047261.34592802
41Vitamin B6 metabolism_Homo sapiens_hsa007501.34265256
42Gastric acid secretion_Homo sapiens_hsa049711.30879546
43GnRH signaling pathway_Homo sapiens_hsa049121.30670138
44Cocaine addiction_Homo sapiens_hsa050301.29316641
45Oxytocin signaling pathway_Homo sapiens_hsa049211.29269513
46Aldosterone synthesis and secretion_Homo sapiens_hsa049251.29200712
47Renal cell carcinoma_Homo sapiens_hsa052111.28418281
48Cell cycle_Homo sapiens_hsa041101.27470062
49ErbB signaling pathway_Homo sapiens_hsa040121.25472712
50Glioma_Homo sapiens_hsa052141.25470554
51Maturity onset diabetes of the young_Homo sapiens_hsa049501.24442695
52Estrogen signaling pathway_Homo sapiens_hsa049151.22994595
53Endometrial cancer_Homo sapiens_hsa052131.21737879
54Regulation of autophagy_Homo sapiens_hsa041401.20427762
55Colorectal cancer_Homo sapiens_hsa052101.20081881
56Phosphatidylinositol signaling system_Homo sapiens_hsa040701.18997836
57Gap junction_Homo sapiens_hsa045401.16633172
58Fatty acid elongation_Homo sapiens_hsa000621.16168811
59Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.15092805
60Proteasome_Homo sapiens_hsa030501.13577457
61Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.13032574
62Hedgehog signaling pathway_Homo sapiens_hsa043401.12957181
63Taste transduction_Homo sapiens_hsa047421.12754611
64Ether lipid metabolism_Homo sapiens_hsa005651.12618221
65VEGF signaling pathway_Homo sapiens_hsa043701.12024150
66Selenocompound metabolism_Homo sapiens_hsa004501.11998153
67Insulin secretion_Homo sapiens_hsa049111.11929642
68mRNA surveillance pathway_Homo sapiens_hsa030151.11707813
69Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.08619459
70cAMP signaling pathway_Homo sapiens_hsa040241.08368794
71Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.08247233
72MAPK signaling pathway_Homo sapiens_hsa040101.07799555
73Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.07219324
74Tryptophan metabolism_Homo sapiens_hsa003801.06970409
75Neurotrophin signaling pathway_Homo sapiens_hsa047221.06599404
76Type II diabetes mellitus_Homo sapiens_hsa049301.05968304
77Pancreatic cancer_Homo sapiens_hsa052121.04414754
78Base excision repair_Homo sapiens_hsa034101.01928410
79Phospholipase D signaling pathway_Homo sapiens_hsa040721.01304584
80Cysteine and methionine metabolism_Homo sapiens_hsa002701.00122139
81Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.99807287
82Choline metabolism in cancer_Homo sapiens_hsa052310.99792162
83Non-small cell lung cancer_Homo sapiens_hsa052230.98635651
84Linoleic acid metabolism_Homo sapiens_hsa005910.98095504
85Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.96584430
86T cell receptor signaling pathway_Homo sapiens_hsa046600.96389906
87Chemokine signaling pathway_Homo sapiens_hsa040620.96090422
88Sphingolipid signaling pathway_Homo sapiens_hsa040710.95043647
89cGMP-PKG signaling pathway_Homo sapiens_hsa040220.93109355
90B cell receptor signaling pathway_Homo sapiens_hsa046620.92843690
91alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.92394194
92Calcium signaling pathway_Homo sapiens_hsa040200.91625826
93Platelet activation_Homo sapiens_hsa046110.91205479
94Rap1 signaling pathway_Homo sapiens_hsa040150.90362455
95Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.90043693
96Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.89258454
97Ras signaling pathway_Homo sapiens_hsa040140.88824975
98Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.88447277
99Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.88148806
100Chronic myeloid leukemia_Homo sapiens_hsa052200.87212522
101Melanogenesis_Homo sapiens_hsa049160.87003553
102Spliceosome_Homo sapiens_hsa030400.86907362
103mTOR signaling pathway_Homo sapiens_hsa041500.86588016
104Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.86379214
105Thyroid hormone signaling pathway_Homo sapiens_hsa049190.85028349
106Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.85006639
107Osteoclast differentiation_Homo sapiens_hsa043800.82516575
108Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.81656458
109Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.81087961
110Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.81065945
111Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.80528665
112Inositol phosphate metabolism_Homo sapiens_hsa005620.80259225
113Purine metabolism_Homo sapiens_hsa002300.80209074
114Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.79249921
115Endocytosis_Homo sapiens_hsa041440.79226353
116Oocyte meiosis_Homo sapiens_hsa041140.79121376
117Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.78566537
118Prolactin signaling pathway_Homo sapiens_hsa049170.78368625
119Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.76649624
120AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.76090410
121Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.74637769
122Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.74171061
123Parkinsons disease_Homo sapiens_hsa050120.73950123
124DNA replication_Homo sapiens_hsa030300.73457111
125TGF-beta signaling pathway_Homo sapiens_hsa043500.71589675
126Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.71390917
127Wnt signaling pathway_Homo sapiens_hsa043100.70808842
128Adherens junction_Homo sapiens_hsa045200.70096584
129Nucleotide excision repair_Homo sapiens_hsa034200.69961169
130Caffeine metabolism_Homo sapiens_hsa002320.69947010
131Regulation of actin cytoskeleton_Homo sapiens_hsa048100.69704756
132Basal cell carcinoma_Homo sapiens_hsa052170.69152294
133Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.69046456
134Fatty acid metabolism_Homo sapiens_hsa012120.68060655
135Vascular smooth muscle contraction_Homo sapiens_hsa042700.65208662
136Oxidative phosphorylation_Homo sapiens_hsa001900.64935231
137Carbohydrate digestion and absorption_Homo sapiens_hsa049730.64859656
138One carbon pool by folate_Homo sapiens_hsa006700.62127110
139Dilated cardiomyopathy_Homo sapiens_hsa054140.61168629
140Shigellosis_Homo sapiens_hsa051310.60940358
141Salmonella infection_Homo sapiens_hsa051320.60741255
142Nitrogen metabolism_Homo sapiens_hsa009100.60071843
143FoxO signaling pathway_Homo sapiens_hsa040680.59228695
144beta-Alanine metabolism_Homo sapiens_hsa004100.58953993
145Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.58828510
146Peroxisome_Homo sapiens_hsa041460.58620632
147MicroRNAs in cancer_Homo sapiens_hsa052060.58431508
148Lysine degradation_Homo sapiens_hsa003100.57324767
149Viral myocarditis_Homo sapiens_hsa054160.57065325
150Focal adhesion_Homo sapiens_hsa045100.56731978
151Pyruvate metabolism_Homo sapiens_hsa006200.56413593
152Leukocyte transendothelial migration_Homo sapiens_hsa046700.55620027
153Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.55157614
154Phototransduction_Homo sapiens_hsa047440.54540243
155Proteoglycans in cancer_Homo sapiens_hsa052050.54113449
156Toxoplasmosis_Homo sapiens_hsa051450.53608269
157Hippo signaling pathway_Homo sapiens_hsa043900.53552558
158Longevity regulating pathway - mammal_Homo sapiens_hsa042110.53108742
159Prostate cancer_Homo sapiens_hsa052150.52602543
160Retinol metabolism_Homo sapiens_hsa008300.51545810
161Circadian rhythm_Homo sapiens_hsa047100.50151398
162p53 signaling pathway_Homo sapiens_hsa041150.50134614
163Huntingtons disease_Homo sapiens_hsa050160.48667991
164Vitamin digestion and absorption_Homo sapiens_hsa049770.47814742
165Primary bile acid biosynthesis_Homo sapiens_hsa001200.42666010
166Fat digestion and absorption_Homo sapiens_hsa049750.41244595
167Fatty acid degradation_Homo sapiens_hsa000710.41053965
168Metabolic pathways_Homo sapiens_hsa011000.37834893
169Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.37687862
170Pentose and glucuronate interconversions_Homo sapiens_hsa000400.36331700
171Collecting duct acid secretion_Homo sapiens_hsa049660.34858739
172Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.34524888

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