ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	formation of translation preinitiation complex (GO:0001731)	3.23852349
2	chaperone mediated protein folding requiring cofactor (GO:0051085)	3.23233399
3	positive regulation of type I interferon-mediated signaling pathway (GO:0060340)	3.20046184
4	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.13187759
5	immunoglobulin mediated immune response (GO:0016064)	3.06457042
6	mitotic sister chromatid cohesion (GO:0007064)	2.85761713
7	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	2.81244675
8	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	2.77783025
9	pentose-phosphate shunt (GO:0006098)	2.77534070
10	N-acetylneuraminate metabolic process (GO:0006054)	2.75788070
11	mitotic nuclear envelope reassembly (GO:0007084)	2.74279127
12	nuclear envelope reassembly (GO:0031468)	2.74279127
13	interferon-gamma secretion (GO:0072643)	2.72439265
14	B cell mediated immunity (GO:0019724)	2.71072727
15	trophectodermal cell differentiation (GO:0001829)	2.66724224
16	folic acid-containing compound biosynthetic process (GO:0009396)	2.66296338
17	nucleobase-containing small molecule interconversion (GO:0015949)	2.66019676
18	NADPH regeneration (GO:0006740)	2.61027455
19	ribosome assembly (GO:0042255)	2.60815700
20	amyloid precursor protein catabolic process (GO:0042987)	2.60387482
21	pyrimidine nucleotide catabolic process (GO:0006244)	2.58149222
22	purine ribonucleotide transport (GO:0015868)	2.55967633
23	deoxyribose phosphate catabolic process (GO:0046386)	2.55860046
24	positive regulation by organism of defense response of other organism involved in symbiotic interact	2.55383858
25	modulation by symbiont of host immune response (GO:0052553)	2.55383858
26	positive regulation by symbiont of host defense response (GO:0052509)	2.55383858
27	modulation by symbiont of host defense response (GO:0052031)	2.55383858
28	modulation by organism of immune response of other organism involved in symbiotic interaction (GO:00	2.55383858
29	modulation by organism of defense response of other organism involved in symbiotic interaction (GO:0	2.55383858
30	positive regulation of Cdc42 GTPase activity (GO:0043089)	2.53393487
31	L-alpha-amino acid transmembrane transport (GO:1902475)	2.51055790
32	regulation of mitochondrial translation (GO:0070129)	2.48631797
33	pentose metabolic process (GO:0019321)	2.45924700
34	ribosomal small subunit assembly (GO:0000028)	2.45033487
35	positive regulation of keratinocyte differentiation (GO:0045618)	2.44298564
36	deoxyribonucleotide catabolic process (GO:0009264)	2.43251813
37	negative regulation of release of cytochrome c from mitochondria (GO:0090201)	2.42765174
38	positive regulation of translational initiation (GO:0045948)	2.42069336
39	positive regulation of lymphocyte apoptotic process (GO:0070230)	2.41367179
40	adenine nucleotide transport (GO:0051503)	2.39942547
41	biotin metabolic process (GO:0006768)	2.39526498
42	regulation of double-strand break repair via homologous recombination (GO:0010569)	2.39298990
43	epithelial cell differentiation involved in prostate gland development (GO:0060742)	2.37015271
44	regulation of type I interferon-mediated signaling pathway (GO:0060338)	2.36122829
45	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.35003272
46	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.35003272
47	regulation of chemokine biosynthetic process (GO:0045073)	2.32146986
48	response to peptidoglycan (GO:0032494)	2.31424011
49	GDP-mannose metabolic process (GO:0019673)	2.31387769
50	regulation of interferon-alpha production (GO:0032647)	2.30859020
51	3-UTR-mediated mRNA stabilization (GO:0070935)	2.30624472
52	antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)	2.29843980
53	rRNA transcription (GO:0009303)	2.28511274
54	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:	2.28348986
55	dosage compensation (GO:0007549)	2.27634063
56	regulation of early endosome to late endosome transport (GO:2000641)	2.26653308
57	positive regulation of interferon-alpha production (GO:0032727)	2.26468981
58	ribosomal small subunit biogenesis (GO:0042274)	2.25510585
59	cellular response to thyroid hormone stimulus (GO:0097067)	2.24460866
60	positive regulation of interferon-beta production (GO:0032728)	2.23793356
61	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class	2.23541531
62	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.23519309
63	fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)	2.22901244
64	rRNA modification (GO:0000154)	2.19791454
65	positive regulation of T cell apoptotic process (GO:0070234)	2.19489070
66	glucose catabolic process (GO:0006007)	2.19449286
67	Golgi transport vesicle coating (GO:0048200)	2.18922812
68	COPI coating of Golgi vesicle (GO:0048205)	2.18922812
69	vagina development (GO:0060068)	2.16590633
70	deoxyribonucleotide biosynthetic process (GO:0009263)	2.15239370
71	histone H2B ubiquitination (GO:0033523)	2.14292044
72	COPII vesicle coating (GO:0048208)	2.13979296
73	deoxyribonucleoside diphosphate metabolic process (GO:0009186)	2.13092454
74	DNA replication initiation (GO:0006270)	2.12876847
75	negative regulation of type I interferon production (GO:0032480)	2.12120201
76	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.11545594
77	ncRNA 3-end processing (GO:0043628)	2.11356937
78	viral mRNA export from host cell nucleus (GO:0046784)	2.11191810
79	negative regulation of ligase activity (GO:0051352)	2.10397308
80	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.10397308
81	purine deoxyribonucleotide catabolic process (GO:0009155)	2.09285928
82	hepatocyte apoptotic process (GO:0097284)	2.08156621
83	virion assembly (GO:0019068)	2.07635065
84	regulation of cell-cell adhesion mediated by cadherin (GO:2000047)	2.05294958
85	response to hydroperoxide (GO:0033194)	2.05276210
86	DNA strand elongation (GO:0022616)	2.05243424
87	lipopolysaccharide-mediated signaling pathway (GO:0031663)	2.05243347
88	cellular response to arsenic-containing substance (GO:0071243)	2.04345608
89	nitric oxide biosynthetic process (GO:0006809)	2.04321522
90	mitotic metaphase plate congression (GO:0007080)	2.02803509
91	DNA strand elongation involved in DNA replication (GO:0006271)	2.02624114
92	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.02366220
93	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.02276184
94	positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)	2.02121847
95	regulation of cellular amino acid metabolic process (GO:0006521)	2.01692159
96	regulation of translational initiation (GO:0006446)	2.00395701
97	intracellular lipid transport (GO:0032365)	2.00318939
98	DNA unwinding involved in DNA replication (GO:0006268)	1.99561263
99	regulation of interferon-beta biosynthetic process (GO:0045357)	1.99537914
100	regulation of interferon-beta production (GO:0032648)	1.99322414

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	3.91067511
2	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.74558967
3	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	2.60001702
4	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	2.27017204
5	ZFX_18555785_ChIP-Seq_MESCs_Mouse	2.18296355
6	VDR_21846776_ChIP-Seq_THP-1_Human	2.17156325
7	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.16385124
8	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.16207118
9	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.13973848
10	DCP1A_22483619_ChIP-Seq_HELA_Human	1.97320408
11	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.96808892
12	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.95904717
13	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.93649621
14	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.92691128
15	MYC_22102868_ChIP-Seq_BL_Human	1.86551895
16	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.84300511
17	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.82672987
18	TFEB_21752829_ChIP-Seq_HELA_Human	1.81744222
19	KDM5A_27292631_Chip-Seq_BREAST_Human	1.80540705
20	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.79137785
21	ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.78398342
22	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	1.76305286
23	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	1.73627772
24	GABP_19822575_ChIP-Seq_HepG2_Human	1.73514745
25	EGR1_19374776_ChIP-ChIP_THP-1_Human	1.71957349
26	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.68140318
27	ZNF263_19887448_ChIP-Seq_K562_Human	1.66815994
28	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.66797409
29	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.66780022
30	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.66765075
31	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.64942452
32	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.63340697
33	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	1.61646018
34	XRN2_22483619_ChIP-Seq_HELA_Human	1.61283404
35	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.58621182
36	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.55975535
37	* SPI1_23547873_ChIP-Seq_NB4_Human	1.53849976
38	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.53635486
39	FOXP3_21729870_ChIP-Seq_TREG_Human	1.51884885
40	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.51797806
41	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.51378318
42	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.51333095
43	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.49898297
44	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.45536503
45	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.44258999
46	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.43346229
47	KLF4_18555785_ChIP-Seq_MESCs_Mouse	1.40593616
48	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.39605411
49	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	1.38543157
50	CIITA_25753668_ChIP-Seq_RAJI_Human	1.38385763
51	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.37558872
52	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.37461635
53	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.36829476
54	VDR_23849224_ChIP-Seq_CD4+_Human	1.36751411
55	MYB_21317192_ChIP-Seq_ERMYB_Mouse	1.36054334
56	RACK7_27058665_Chip-Seq_MCF-7_Human	1.34199391
57	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.33999577
58	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.33606482
59	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.33333310
60	CHD1_26751641_Chip-Seq_LNCaP_Human	1.33327675
61	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.32995224
62	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.32353510
63	TTF2_22483619_ChIP-Seq_HELA_Human	1.32034130
64	SCL_19346495_ChIP-Seq_HPC-7_Human	1.31664699
65	AR_21909140_ChIP-Seq_LNCAP_Human	1.29594287
66	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.28728746
67	NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse	1.28160374
68	MECOM_23826213_ChIP-Seq_KASUMI_Mouse	1.25950633
69	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.25924067
70	VDR_24763502_ChIP-Seq_THP-1_Human	1.25841023
71	SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse	1.25760254
72	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.25513021
73	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.25391065
74	GATA2_22383799_ChIP-Seq_G1ME_Mouse	1.25377909
75	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.24895491
76	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.23801820
77	GATA1_22383799_ChIP-Seq_G1ME_Mouse	1.21630141
78	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.19631534
79	NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse	1.19399625
80	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	1.19125331
81	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.16499729
82	TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.16264616
83	ELF5_23300383_ChIP-Seq_T47D_Human	1.15281793
84	GFI1B_20887958_ChIP-Seq_HPC-7_Mouse	1.13626919
85	STAT3_1855785_ChIP-Seq_MESCs_Mouse	1.12410067
86	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.12203244
87	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	1.11868752
88	BRD4_27068464_Chip-Seq_AML-cells_Mouse	1.09571148
89	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.08194374
90	RUNX1_22412390_ChIP-Seq_EML_Mouse	1.05695760
91	CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse	1.05421688
92	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.05338765
93	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.04255451
94	TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse	1.01616836
95	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.00749449
96	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.00347450
97	SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse	1.00190084
98	STAT4_19710469_ChIP-ChIP_TH1__Mouse	0.99671272
99	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	0.99110106
100	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	0.97680755

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008057_abnormal_DNA_replication	3.59740658
2	MP0005075_abnormal_melanosome_morpholog	3.17033234
3	MP0009840_abnormal_foam_cell	3.16061766
4	MP0005058_abnormal_lysosome_morphology	2.72700260
5	MP0010234_abnormal_vibrissa_follicle	2.58021737
6	MP0003191_abnormal_cellular_cholesterol	2.55381332
7	MP0002877_abnormal_melanocyte_morpholog	2.41659176
8	MP0003123_paternal_imprinting	2.38760921
9	MP0008007_abnormal_cellular_replicative	2.25836900
10	MP0004957_abnormal_blastocyst_morpholog	2.11736717
11	MP0010094_abnormal_chromosome_stability	2.11351784
12	MP0002796_impaired_skin_barrier	2.04135278
13	MP0003693_abnormal_embryo_hatching	2.00776669
14	MP0005451_abnormal_body_composition	1.94122672
15	MP0001727_abnormal_embryo_implantation	1.90664720
16	MP0003111_abnormal_nucleus_morphology	1.89146532
17	MP0003186_abnormal_redox_activity	1.76535200
18	MP0003303_peritoneal_inflammation	1.70302428
19	MP0005076_abnormal_cell_differentiation	1.67760383
20	MP0004264_abnormal_extraembryonic_tissu	1.67143998
21	MP0004185_abnormal_adipocyte_glucose	1.66369139
22	MP0003077_abnormal_cell_cycle	1.60026891
23	MP0003172_abnormal_lysosome_physiology	1.58108351
24	MP0010352_gastrointestinal_tract_polyps	1.55297830
25	MP0010307_abnormal_tumor_latency	1.51670732
26	MP0001835_abnormal_antigen_presentation	1.48940070
27	MP0003806_abnormal_nucleotide_metabolis	1.48877783
28	MP0004808_abnormal_hematopoietic_stem	1.39809068
29	MP0009697_abnormal_copulation	1.38362439
30	MP0005501_abnormal_skin_physiology	1.36830981
31	MP0005464_abnormal_platelet_physiology	1.36232820
32	MP0003724_increased_susceptibility_to	1.35848185
33	MP0002009_preneoplasia	1.35590549
34	MP0000490_abnormal_crypts_of	1.34532204
35	MP0004381_abnormal_hair_follicle	1.33791151
36	MP0004782_abnormal_surfactant_physiolog	1.33173913
37	MP0003763_abnormal_thymus_physiology	1.31820079
38	MP0002148_abnormal_hypersensitivity_rea	1.30344607
39	MP0001730_embryonic_growth_arrest	1.24086041
40	MP0003300_gastrointestinal_ulcer	1.23638898
41	MP0001881_abnormal_mammary_gland	1.22378662
42	MP0008004_abnormal_stomach_pH	1.19967491
43	MP0003183_abnormal_peptide_metabolism	1.19202781
44	MP0009785_altered_susceptibility_to	1.18934944
45	MP0009333_abnormal_splenocyte_physiolog	1.16254814
46	MP0008932_abnormal_embryonic_tissue	1.14331779
47	MP0006035_abnormal_mitochondrial_morpho	1.14016265
48	MP0000371_diluted_coat_color	1.13080454
49	MP0008058_abnormal_DNA_repair	1.12968960
50	MP0008877_abnormal_DNA_methylation	1.12546908
51	MP0005025_abnormal_response_to	1.11615973
52	MP0001800_abnormal_humoral_immune	1.11594547
53	MP0002098_abnormal_vibrissa_morphology	1.10257523
54	MP0000015_abnormal_ear_pigmentation	1.09862850
55	MP0000627_abnormal_mammary_gland	1.09247112
56	MP0005000_abnormal_immune_tolerance	1.07792242
57	MP0002452_abnormal_antigen_presenting	1.07402055
58	MP0003453_abnormal_keratinocyte_physiol	1.06174912
59	MP0002398_abnormal_bone_marrow	1.05007563
60	MP0002139_abnormal_hepatobiliary_system	1.03409012
61	MP0001819_abnormal_immune_cell	1.03128167
62	MP0002166_altered_tumor_susceptibility	1.01984012
63	MP0003436_decreased_susceptibility_to	1.01657750
64	MP0005666_abnormal_adipose_tissue	1.01553566
65	MP0002420_abnormal_adaptive_immunity	1.01239678
66	MP0000462_abnormal_digestive_system	1.00877347
67	MP0009672_abnormal_birth_weight	1.00494139
68	MP0002722_abnormal_immune_system	1.00056959
69	MP0000358_abnormal_cell_content/	0.99781631
70	MP0004947_skin_inflammation	0.99250502
71	MP0002723_abnormal_immune_serum	0.98747469
72	MP0000350_abnormal_cell_proliferation	0.97923459
73	MP0002419_abnormal_innate_immunity	0.97472690
74	MP0000313_abnormal_cell_death	0.96915103
75	MP0005319_abnormal_enzyme/_coenzyme	0.96307770
76	MP0001873_stomach_inflammation	0.95643196
77	MP0002396_abnormal_hematopoietic_system	0.95324978
78	MP0010155_abnormal_intestine_physiology	0.94450998
79	MP0001764_abnormal_homeostasis	0.93946057
80	MP0005387_immune_system_phenotype	0.90847354
81	MP0001790_abnormal_immune_system	0.90847354
82	MP0001845_abnormal_inflammatory_respons	0.90564929
83	MP0000716_abnormal_immune_system	0.90292598
84	MP0002429_abnormal_blood_cell	0.89448254
85	MP0000689_abnormal_spleen_morphology	0.88100579
86	MP0004233_abnormal_muscle_weight	0.88100277
87	MP0001853_heart_inflammation	0.86515808
88	MP0006036_abnormal_mitochondrial_physio	0.86400605
89	MP0005647_abnormal_sex_gland	0.85079375
90	MP0000598_abnormal_liver_morphology	0.83593371
91	MP0008469_abnormal_protein_level	0.83213250
92	MP0000609_abnormal_liver_physiology	0.83123663
93	MP0000703_abnormal_thymus_morphology	0.82995742
94	MP0003656_abnormal_erythrocyte_physiolo	0.82726213
95	MP0004147_increased_porphyrin_level	0.82366971
96	MP0003866_abnormal_defecation	0.82190484
97	MP0003221_abnormal_cardiomyocyte_apopto	0.82177336
98	MP0000477_abnormal_intestine_morphology	0.81133045
99	MP0008260_abnormal_autophagy	0.79706270
100	MP0009379_abnormal_foot_pigmentation	0.78331833

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Loss of speech (HP:0002371)	3.49481418
2	J-shaped sella turcica (HP:0002680)	3.44989381
3	Ragged-red muscle fibers (HP:0003200)	3.44206160
4	Dysostosis multiplex (HP:0000943)	3.20981263
5	Increased neuronal autofluorescent lipopigment (HP:0002074)	3.18270004
6	Increased cerebral lipofuscin (HP:0011813)	3.12835669
7	Mucopolysacchariduria (HP:0008155)	3.11908507
8	Urinary glycosaminoglycan excretion (HP:0003541)	3.11908507
9	Systemic lupus erythematosus (HP:0002725)	3.08592520
10	Axonal loss (HP:0003447)	3.02400903
11	B lymphocytopenia (HP:0010976)	3.00993116
12	Abnormality of glycolipid metabolism (HP:0010969)	3.00338132
13	Abnormality of liposaccharide metabolism (HP:0010968)	3.00338132
14	Abnormality of glycosphingolipid metabolism (HP:0004343)	3.00338132
15	Abnormality of polysaccharide metabolism (HP:0011012)	2.98102888
16	Abnormality of glycosaminoglycan metabolism (HP:0004371)	2.98102888
17	Abnormality of mucopolysaccharide metabolism (HP:0011020)	2.98102888
18	Microvesicular hepatic steatosis (HP:0001414)	2.88753203
19	Abnormality of B cell number (HP:0010975)	2.86758459
20	Reduced antithrombin III activity (HP:0001976)	2.82087193
21	Thin bony cortex (HP:0002753)	2.70110293
22	Abnormal protein glycosylation (HP:0012346)	2.67796785
23	Abnormal glycosylation (HP:0012345)	2.67796785
24	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.67796785
25	Abnormal protein N-linked glycosylation (HP:0012347)	2.67796785
26	Sensorimotor neuropathy (HP:0007141)	2.67381575
27	Type I transferrin isoform profile (HP:0003642)	2.59780836
28	Lipid accumulation in hepatocytes (HP:0006561)	2.59330543
29	Hyperparathyroidism (HP:0000843)	2.58538924
30	Progressive neurologic deterioration (HP:0002344)	2.51255058
31	Hypokinesia (HP:0002375)	2.43128479
32	Vacuolated lymphocytes (HP:0001922)	2.42845255
33	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	2.41492941
34	Deformed sella turcica (HP:0002681)	2.41023424
35	Breast carcinoma (HP:0003002)	2.37245345
36	Prostate neoplasm (HP:0100787)	2.36982583
37	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	2.35034501
38	Increased muscle lipid content (HP:0009058)	2.32709023
39	Septate vagina (HP:0001153)	2.31893312
40	Progressive muscle weakness (HP:0003323)	2.31601487
41	Asymmetric septal hypertrophy (HP:0001670)	2.31212209
42	Sparse lateral eyebrow (HP:0005338)	2.29642302
43	Thrombocytosis (HP:0001894)	2.29631954
44	Hyperammonemia (HP:0001987)	2.29065146
45	Increased hepatocellular lipid droplets (HP:0006565)	2.27716676
46	Abnormality of the thoracic spine (HP:0100711)	2.27162200
47	Abnormality of small intestinal villus morphology (HP:0011472)	2.21619856
48	Villous atrophy (HP:0011473)	2.21619856
49	Renal Fanconi syndrome (HP:0001994)	2.16542089
50	Periodontitis (HP:0000704)	2.11888349
51	Prolonged neonatal jaundice (HP:0006579)	2.10735609
52	Recurrent abscess formation (HP:0002722)	2.08756557
53	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.08221157
54	Abnormality of alanine metabolism (HP:0010916)	2.08221157
55	Hyperalaninemia (HP:0003348)	2.08221157
56	Pancytopenia (HP:0001876)	2.05657043
57	Thoracic kyphosis (HP:0002942)	2.03355702
58	Neutropenia (HP:0001875)	1.97438801
59	Cardiomegaly (HP:0001640)	1.96314446
60	Abnormality of macrophages (HP:0004311)	1.94278410
61	Amelogenesis imperfecta (HP:0000705)	1.94055329
62	Increased intramyocellular lipid droplets (HP:0012240)	1.92591244
63	Hypercortisolism (HP:0001578)	1.92231612
64	Autoimmune hemolytic anemia (HP:0001890)	1.91473894
65	Multiple enchondromatosis (HP:0005701)	1.89486127
66	Abnormality of the costochondral junction (HP:0000919)	1.89293565
67	Aplasia/Hypoplasia of the sacrum (HP:0008517)	1.87595504
68	Eczematoid dermatitis (HP:0000976)	1.85880017
69	Increased IgM level (HP:0003496)	1.85684282
70	Chromosomal breakage induced by crosslinking agents (HP:0003221)	1.85566466
71	Recurrent bacterial skin infections (HP:0005406)	1.85541505
72	Abnormal trabecular bone morphology (HP:0100671)	1.78906823
73	Abnormality of fatty-acid metabolism (HP:0004359)	1.78317441
74	Neoplasm of the pancreas (HP:0002894)	1.77124521
75	Selective tooth agenesis (HP:0001592)	1.74996247
76	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	1.73779296
77	Abnormality of the prostate (HP:0008775)	1.73638831
78	Acute myeloid leukemia (HP:0004808)	1.71967188
79	Micronodular cirrhosis (HP:0001413)	1.71518080
80	Chromsome breakage (HP:0040012)	1.70575175
81	Elevated hepatic transaminases (HP:0002910)	1.70405359
82	Diaphragmatic weakness (HP:0009113)	1.69812480
83	Ketosis (HP:0001946)	1.68669630
84	Hypergammaglobulinemia (HP:0010702)	1.67608536
85	Premature loss of primary teeth (HP:0006323)	1.67046935
86	Bulbar palsy (HP:0001283)	1.66879281
87	Fasciculations (HP:0002380)	1.66813787
88	Testicular atrophy (HP:0000029)	1.64710630
89	Flat acetabular roof (HP:0003180)	1.64497533
90	Increased serum pyruvate (HP:0003542)	1.64441945
91	Gastrointestinal inflammation (HP:0004386)	1.64380465
92	Cone-rod dystrophy (HP:0000548)	1.63532538
93	Bone pain (HP:0002653)	1.63388740
94	Abnormality of dental color (HP:0011073)	1.61991065
95	Intrahepatic cholestasis (HP:0001406)	1.60311518
96	Progressive external ophthalmoplegia (HP:0000590)	1.58042519
97	Mediastinal lymphadenopathy (HP:0100721)	1.57116988
98	Petechiae (HP:0000967)	1.56701790
99	Rhabdomyolysis (HP:0003201)	1.56655993
100	Fatigue (HP:0012378)	1.56370539

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	SCYL2	3.99622869
2	IRAK3	3.94766624
3	TRIB3	3.50380708
4	NME2	3.12598223
5	MST4	2.75692642
6	MAP3K12	2.21861615
7	CDK19	2.19479361
8	ACVR1B	2.12903737
9	SMG1	2.11910315
10	BCKDK	2.01375442
11	TAOK2	1.88893394
12	PRPF4B	1.83757626
13	RPS6KB2	1.79439729
14	PBK	1.76746368
15	MAP3K11	1.76398086
16	IRAK4	1.74519731
17	MUSK	1.72846254
18	EIF2AK1	1.68574402
19	ERN1	1.61417111
20	SIK1	1.60202771
21	ARAF	1.57631953
22	EIF2AK3	1.53647719
23	TYK2	1.44272261
24	IKBKE	1.43104381
25	BMPR2	1.31842722
26	PIK3CA	1.31024977
27	PIM2	1.28950366
28	LRRK2	1.25026107
29	PRKCI	1.19311838
30	PRKD2	1.19261094
31	STK16	1.18573646
32	MAP2K3	1.17988581
33	MAP3K5	1.17946239
34	MAP3K1	1.15001431
35	IRAK2	1.12886517
36	DYRK1B	1.10775516
37	BLK	1.09307396
38	VRK2	1.09197953
39	TESK2	1.07919921
40	TBK1	1.06239248
41	CDK6	0.97226940
42	PKN2	0.93354052
43	MATK	0.90254860
44	TESK1	0.87755000
45	MAPK11	0.83731924
46	BRAF	0.82012903
47	GRK6	0.81275575
48	CDK7	0.80551045
49	EEF2K	0.79145733
50	ATR	0.77961939
51	TTK	0.76191165
52	RIPK4	0.75372784
53	TAOK1	0.75148500
54	EPHA2	0.74969444
55	ILK	0.74634126
56	JAK3	0.72121995
57	MAPKAPK3	0.71326801
58	MAP3K13	0.70566729
59	DMPK	0.67276031
60	STK4	0.66814978
61	MAP3K3	0.65641176
62	MAP3K2	0.64056887
63	DYRK3	0.62366624
64	PLK1	0.61948123
65	AURKA	0.61724521
66	CDK4	0.61600338
67	PAK4	0.61058231
68	DAPK1	0.60779082
69	ICK	0.60675800
70	AURKB	0.59727832
71	MAP3K8	0.59309092
72	RAF1	0.57527184
73	HIPK2	0.55034485
74	MAP3K14	0.53832937
75	AKT2	0.52290501
76	MAP3K9	0.52079658
77	PDPK1	0.49872343
78	CSK	0.49845925
79	ALK	0.49477335
80	PRKG2	0.49352204
81	CCNB1	0.48142962
82	IRAK1	0.47036805
83	CSF1R	0.46796613
84	MELK	0.45578863
85	MTOR	0.44519550
86	PIM1	0.43871411
87	EPHB1	0.43627495
88	KSR2	0.42015457
89	IKBKB	0.41931083
90	NUAK1	0.41501177
91	STK39	0.40958327
92	PAK1	0.38475623
93	RPS6KL1	0.37693094
94	RPS6KC1	0.37693094
95	CHUK	0.36386857
96	MAP2K2	0.35427169
97	RPS6KA4	0.34208780
98	CHEK2	0.34021909
99	ZAK	0.33710832
100	TNK2	0.33677228

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosaminoglycan degradation_Homo sapiens_hsa00531	3.03171471
2	Folate biosynthesis_Homo sapiens_hsa00790	2.79110803
3	Proteasome_Homo sapiens_hsa03050	2.77371086
4	DNA replication_Homo sapiens_hsa03030	2.62720389
5	Base excision repair_Homo sapiens_hsa03410	2.46322125
6	Sulfur relay system_Homo sapiens_hsa04122	2.01899265
7	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.90037331
8	Lysosome_Homo sapiens_hsa04142	1.88136811
9	Other glycan degradation_Homo sapiens_hsa00511	1.76991435
10	Mismatch repair_Homo sapiens_hsa03430	1.73206837
11	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.64468168
12	Pyrimidine metabolism_Homo sapiens_hsa00240	1.62635692
13	Ribosome_Homo sapiens_hsa03010	1.61393389
14	Fatty acid elongation_Homo sapiens_hsa00062	1.48595709
15	Hepatitis C_Homo sapiens_hsa05160	1.46887628
16	Acute myeloid leukemia_Homo sapiens_hsa05221	1.46597132
17	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	1.42127616
18	B cell receptor signaling pathway_Homo sapiens_hsa04662	1.42119874
19	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.36652387
20	RNA polymerase_Homo sapiens_hsa03020	1.32796932
21	Leishmaniasis_Homo sapiens_hsa05140	1.31509103
22	Pentose phosphate pathway_Homo sapiens_hsa00030	1.30727485
23	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	1.27826661
24	Thyroid cancer_Homo sapiens_hsa05216	1.25209091
25	Galactose metabolism_Homo sapiens_hsa00052	1.24193723
26	Glutathione metabolism_Homo sapiens_hsa00480	1.18661340
27	Asthma_Homo sapiens_hsa05310	1.16882228
28	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.16186251
29	Epstein-Barr virus infection_Homo sapiens_hsa05169	1.15558119
30	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.15389993
31	Homologous recombination_Homo sapiens_hsa03440	1.13089127
32	Non-homologous end-joining_Homo sapiens_hsa03450	1.10884083
33	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.08696038
34	Herpes simplex infection_Homo sapiens_hsa05168	1.08582553
35	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.07483812
36	Fanconi anemia pathway_Homo sapiens_hsa03460	1.07348484
37	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.06990334
38	Osteoclast differentiation_Homo sapiens_hsa04380	1.04749755
39	RNA transport_Homo sapiens_hsa03013	1.01636398
40	Endometrial cancer_Homo sapiens_hsa05213	1.01129959
41	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.97313262
42	Non-small cell lung cancer_Homo sapiens_hsa05223	0.96544476
43	Type I diabetes mellitus_Homo sapiens_hsa04940	0.94589754
44	Cell cycle_Homo sapiens_hsa04110	0.94329680
45	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.91926442
46	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.91166261
47	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.89479306
48	Spliceosome_Homo sapiens_hsa03040	0.88765080
49	Influenza A_Homo sapiens_hsa05164	0.88272230
50	Tuberculosis_Homo sapiens_hsa05152	0.88234367
51	Bladder cancer_Homo sapiens_hsa05219	0.83946495
52	Propanoate metabolism_Homo sapiens_hsa00640	0.83575760
53	Hepatitis B_Homo sapiens_hsa05161	0.82379100
54	Legionellosis_Homo sapiens_hsa05134	0.81113278
55	Allograft rejection_Homo sapiens_hsa05330	0.80344720
56	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.80227862
57	Nucleotide excision repair_Homo sapiens_hsa03420	0.79627226
58	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.76179002
59	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.75999172
60	Pyruvate metabolism_Homo sapiens_hsa00620	0.75801272
61	Primary immunodeficiency_Homo sapiens_hsa05340	0.75469441
62	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.72344118
63	p53 signaling pathway_Homo sapiens_hsa04115	0.71102247
64	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.70117531
65	Measles_Homo sapiens_hsa05162	0.69840221
66	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.69600878
67	mTOR signaling pathway_Homo sapiens_hsa04150	0.69338433
68	mRNA surveillance pathway_Homo sapiens_hsa03015	0.69010899
69	Carbon metabolism_Homo sapiens_hsa01200	0.68630898
70	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.67675145
71	Rheumatoid arthritis_Homo sapiens_hsa05323	0.67575393
72	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.67489233
73	AMPK signaling pathway_Homo sapiens_hsa04152	0.67110220
74	Peroxisome_Homo sapiens_hsa04146	0.66434485
75	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.63295698
76	Pancreatic cancer_Homo sapiens_hsa05212	0.61893907
77	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.61316764
78	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.57004900
79	Viral carcinogenesis_Homo sapiens_hsa05203	0.56663756
80	Antigen processing and presentation_Homo sapiens_hsa04612	0.55539563
81	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.55188917
82	Prostate cancer_Homo sapiens_hsa05215	0.54653260
83	HTLV-I infection_Homo sapiens_hsa05166	0.54230453
84	Graft-versus-host disease_Homo sapiens_hsa05332	0.54004975
85	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.52399190
86	Phagosome_Homo sapiens_hsa04145	0.52259129
87	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.51676971
88	TNF signaling pathway_Homo sapiens_hsa04668	0.51465428
89	Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142	0.51398194
90	Purine metabolism_Homo sapiens_hsa00230	0.51045256
91	Prolactin signaling pathway_Homo sapiens_hsa04917	0.50665161
92	Shigellosis_Homo sapiens_hsa05131	0.49702826
93	Vibrio cholerae infection_Homo sapiens_hsa05110	0.48519040
94	One carbon pool by folate_Homo sapiens_hsa00670	0.48510814
95	Apoptosis_Homo sapiens_hsa04210	0.48004266
96	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.47203407
97	Sphingolipid metabolism_Homo sapiens_hsa00600	0.46580814
98	Toxoplasmosis_Homo sapiens_hsa05145	0.44123009
99	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.42539281
100	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.41697213

FAM120AOS

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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