FAM120B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cornea development in camera-type eye (GO:0061303)9.31378600
2astrocyte differentiation (GO:0048708)7.22038837
3regulation of timing of cell differentiation (GO:0048505)6.33665453
4regulation of development, heterochronic (GO:0040034)6.20919405
5synaptic vesicle endocytosis (GO:0048488)5.72338448
6regulation of short-term neuronal synaptic plasticity (GO:0048172)5.53399261
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.37217078
8gland morphogenesis (GO:0022612)4.98124700
9regulation of glutamate receptor signaling pathway (GO:1900449)4.61798973
10synaptic vesicle exocytosis (GO:0016079)4.54547120
11synaptic vesicle maturation (GO:0016188)4.45574455
12regulation of synaptic vesicle transport (GO:1902803)4.42756068
13hindbrain development (GO:0030902)4.39900772
14positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.38284559
15negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)4.34003052
16locomotory exploration behavior (GO:0035641)4.30030347
17regulation of synaptic vesicle exocytosis (GO:2000300)4.25324292
18regulation of transcription involved in cell fate commitment (GO:0060850)4.24359851
19cytoplasmic mRNA processing body assembly (GO:0033962)4.20792629
20positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.18200633
21ionotropic glutamate receptor signaling pathway (GO:0035235)4.13422968
22positive regulation of cell fate commitment (GO:0010455)4.07031563
23embryonic camera-type eye morphogenesis (GO:0048596)4.06958179
24positive regulation of neuroblast proliferation (GO:0002052)4.05891615
25synaptic vesicle docking involved in exocytosis (GO:0016081)4.05313775
26vocalization behavior (GO:0071625)4.00615669
27regulation of synapse structural plasticity (GO:0051823)3.95913393
28regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.95891505
29protein localization to synapse (GO:0035418)3.95546019
30establishment of protein localization to Golgi (GO:0072600)3.93077392
31synaptic transmission, glutamatergic (GO:0035249)3.91105818
32intraciliary transport (GO:0042073)3.90657513
33pyrimidine nucleobase catabolic process (GO:0006208)3.90357451
34glutamate secretion (GO:0014047)3.87088382
35protein targeting to Golgi (GO:0000042)3.86569914
36regulation of cilium movement (GO:0003352)3.83138535
37glandular epithelial cell development (GO:0002068)3.82190063
38neurotransmitter secretion (GO:0007269)3.80289221
39cilium or flagellum-dependent cell motility (GO:0001539)3.78547999
40histone H3-K9 methylation (GO:0051567)3.74119399
41regulation of long-term neuronal synaptic plasticity (GO:0048169)3.73029817
42cilium morphogenesis (GO:0060271)3.71756813
43regulation of hexokinase activity (GO:1903299)3.64933360
44regulation of glucokinase activity (GO:0033131)3.64933360
45positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)3.63509555
46regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)3.63509555
47photoreceptor cell development (GO:0042461)3.62376713
48regulation of neuronal synaptic plasticity (GO:0048168)3.60685521
49retrograde transport, vesicle recycling within Golgi (GO:0000301)3.58575925
50neuron cell-cell adhesion (GO:0007158)3.58517019
51regulation of synaptic transmission, glutamatergic (GO:0051966)3.57366186
52glutamate receptor signaling pathway (GO:0007215)3.56830371
53response to pheromone (GO:0019236)3.55289699
54negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.52999457
55microtubule nucleation (GO:0007020)3.50936074
56neuron-neuron synaptic transmission (GO:0007270)3.49812542
57regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.49317924
58N-glycan processing (GO:0006491)3.45973629
59exploration behavior (GO:0035640)3.40871490
60neurotransmitter-gated ion channel clustering (GO:0072578)3.36687536
61cellular potassium ion homeostasis (GO:0030007)3.36207025
62peptidyl-lysine trimethylation (GO:0018023)3.35596069
63eye photoreceptor cell development (GO:0042462)3.34807824
64histone H3-K9 modification (GO:0061647)3.33146886
65activation of protein kinase A activity (GO:0034199)3.32726266
66neuron fate commitment (GO:0048663)3.27335598
67neuron recognition (GO:0008038)3.27326307
68protein localization to Golgi apparatus (GO:0034067)3.25206392
69protein polyglutamylation (GO:0018095)3.24867531
70positive regulation of synapse maturation (GO:0090129)3.24339423
71receptor catabolic process (GO:0032801)3.24203476
72membrane depolarization during action potential (GO:0086010)3.23353731
73layer formation in cerebral cortex (GO:0021819)3.21676024
74neuronal action potential propagation (GO:0019227)3.20413841
75neural tube formation (GO:0001841)3.20022092
76neurotransmitter transport (GO:0006836)3.18362648
77cardiac ventricle formation (GO:0003211)3.13591687
78regulation of excitatory postsynaptic membrane potential (GO:0060079)3.11610677
79positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO3.11220251
80regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)3.11220251
81histone H2A monoubiquitination (GO:0035518)3.10854094
82positive regulation of actin filament depolymerization (GO:0030836)3.10699227
83pyrimidine dimer repair (GO:0006290)3.09436136
84synaptic vesicle transport (GO:0048489)3.09130809
85establishment of synaptic vesicle localization (GO:0097480)3.09130809
86dorsal/ventral axis specification (GO:0009950)3.07968099
87epithelial cilium movement (GO:0003351)3.07154832
88long-term synaptic potentiation (GO:0060291)3.06861983
89regulation of neurotransmitter secretion (GO:0046928)3.06853491
90cerebellar Purkinje cell differentiation (GO:0021702)3.06252612
91histone H2A acetylation (GO:0043968)3.06081263
92positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.03473976
93long-term memory (GO:0007616)3.02352415
94artery development (GO:0060840)3.01889870
95regulation of postsynaptic membrane potential (GO:0060078)3.01536997
96macroautophagy (GO:0016236)3.00288916
97cilium movement (GO:0003341)3.00049348
98membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.98217246
99positive regulation of synaptic transmission, GABAergic (GO:0032230)2.98175357
100postsynaptic membrane organization (GO:0001941)2.96450761
101membrane hyperpolarization (GO:0060081)2.96412862
102regulation of synapse maturation (GO:0090128)2.95621985
103proline transport (GO:0015824)2.94370637
104glandular epithelial cell differentiation (GO:0002067)2.94066300
105regulation of neurotransmitter levels (GO:0001505)2.93907860
106neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.93331339
107regulation of synaptic plasticity (GO:0048167)2.92463786
108transmission of nerve impulse (GO:0019226)2.91576257
109cardiac chamber formation (GO:0003207)2.90491037
110negative regulation of glial cell proliferation (GO:0060253)2.90322953
111behavioral fear response (GO:0001662)2.90132710
112behavioral defense response (GO:0002209)2.90132710
113dendrite morphogenesis (GO:0048813)2.89003176
114glycosphingolipid biosynthetic process (GO:0006688)2.88851292
115ventricular system development (GO:0021591)2.87764510
116gastrulation with mouth forming second (GO:0001702)2.87497607
117positive regulation of defense response to virus by host (GO:0002230)2.86602210
118membrane depolarization (GO:0051899)2.85406298
119axonal fasciculation (GO:0007413)2.84837927
120positive regulation of membrane potential (GO:0045838)2.84804621
121axoneme assembly (GO:0035082)2.83733596
122regulation of synaptic transmission, GABAergic (GO:0032228)2.83409375
123RNA destabilization (GO:0050779)2.82075662
124regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.81048644
125positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.81000529
126protein localization to cilium (GO:0061512)2.79990253
127regulation of synaptic transmission (GO:0050804)2.79663835
128cerebral cortex radially oriented cell migration (GO:0021799)2.79532180
129glial cell proliferation (GO:0014009)2.79529562
130regulation of neurotransmitter transport (GO:0051588)2.78696589
131histone H2A ubiquitination (GO:0033522)2.78157586
132intra-Golgi vesicle-mediated transport (GO:0006891)2.78075917
133gamma-aminobutyric acid signaling pathway (GO:0007214)2.77963375
134nucleobase catabolic process (GO:0046113)2.77360034
135positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.77124936
136positive regulation of synaptic transmission (GO:0050806)2.75969582
137dendritic spine morphogenesis (GO:0060997)2.74073427
138gamma-aminobutyric acid transport (GO:0015812)2.74024246
139fear response (GO:0042596)2.73870712
140cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.73408982
141regulation of oligodendrocyte differentiation (GO:0048713)2.73172259
142positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.72019221
143nonmotile primary cilium assembly (GO:0035058)2.70987353
144negative regulation of cytosolic calcium ion concentration (GO:0051481)2.70094341
145mitochondrion degradation (GO:0000422)2.68879515
146regulation of dendritic spine morphogenesis (GO:0061001)2.68506362
147smoothened signaling pathway (GO:0007224)2.68475867
148establishment of vesicle localization (GO:0051650)2.68311747
149cerebellar granule cell differentiation (GO:0021707)2.67080548
150response to auditory stimulus (GO:0010996)2.66826467
151dosage compensation (GO:0007549)2.66237400
152G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.65916992
153regulation of neuroblast proliferation (GO:1902692)2.63495759
154pituitary gland development (GO:0021983)2.62678902
155innervation (GO:0060384)2.61854550
156response to histamine (GO:0034776)2.61511264
157cell communication by electrical coupling (GO:0010644)2.61247699
158presynaptic membrane assembly (GO:0097105)2.60380570
159positive regulation of neural precursor cell proliferation (GO:2000179)2.58033336
160axonemal dynein complex assembly (GO:0070286)2.57769366
161negative regulation of oligodendrocyte differentiation (GO:0048715)2.56820332
162sodium ion export (GO:0071436)2.55678781
163learning (GO:0007612)2.55207850
164inositol phosphate catabolic process (GO:0071545)2.55197148
165neutrophil mediated immunity (GO:0002446)2.54675825
166neuromuscular process controlling balance (GO:0050885)2.53913239
167vesicle transport along microtubule (GO:0047496)2.53876008
168organelle transport along microtubule (GO:0072384)2.53494754
169startle response (GO:0001964)2.53476537
170synapse assembly (GO:0007416)2.52357232
171myelin assembly (GO:0032288)2.51860144
172histone mRNA catabolic process (GO:0071044)2.50365186
173positive regulation of mitochondrial fission (GO:0090141)2.50123195
174embryonic eye morphogenesis (GO:0048048)2.48358912
175activated T cell proliferation (GO:0050798)2.47868011
176auditory behavior (GO:0031223)2.46396605
177mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.44733018
178positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.44733018
179RNA localization (GO:0006403)2.42808165
180columnar/cuboidal epithelial cell development (GO:0002066)2.42113316
181negative thymic T cell selection (GO:0045060)2.38942688
182regulation of microtubule-based movement (GO:0060632)2.37742327
183lens development in camera-type eye (GO:0002088)2.36936147
184regulation of protein kinase A signaling (GO:0010738)2.34852736
185positive regulation of oligodendrocyte differentiation (GO:0048714)2.33599166
186limb bud formation (GO:0060174)2.33036382
187negative regulation of granulocyte differentiation (GO:0030853)2.32851934
188microtubule-based transport (GO:0010970)2.32499629
189peptidyl-lysine methylation (GO:0018022)2.31901033
190positive regulation of TOR signaling (GO:0032008)2.31877905
191regulation of granulocyte differentiation (GO:0030852)2.28646328
192Golgi to endosome transport (GO:0006895)2.27623965
193calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.26121721
194positive regulation of granulocyte differentiation (GO:0030854)2.25748264

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.00710054
2GBX2_23144817_ChIP-Seq_PC3_Human3.61792066
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.79137288
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.75887442
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.54845823
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.49816303
7DROSHA_22980978_ChIP-Seq_HELA_Human2.43486155
8SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.38947991
9MTF2_20144788_ChIP-Seq_MESCs_Mouse2.37295862
10SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.35448385
11REST_21632747_ChIP-Seq_MESCs_Mouse2.35244350
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.34777740
13IRF8_22096565_ChIP-ChIP_GC-B_Human2.34168378
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.33368468
15JARID2_20075857_ChIP-Seq_MESCs_Mouse2.31794479
16EZH2_18974828_ChIP-Seq_MESCs_Mouse2.21327189
17RNF2_18974828_ChIP-Seq_MESCs_Mouse2.21327189
18HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.20588634
19EZH2_27294783_Chip-Seq_ESCs_Mouse2.13529936
20AR_21572438_ChIP-Seq_LNCaP_Human2.12107970
21EED_16625203_ChIP-ChIP_MESCs_Mouse2.10831414
22EZH2_27304074_Chip-Seq_ESCs_Mouse2.06002000
23PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.97168015
24SUZ12_27294783_Chip-Seq_ESCs_Mouse1.94355119
25RARB_27405468_Chip-Seq_BRAIN_Mouse1.93244503
26CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.90856991
27IKZF1_21737484_ChIP-ChIP_HCT116_Human1.88404519
28REST_18959480_ChIP-ChIP_MESCs_Mouse1.86502926
29RNF2_27304074_Chip-Seq_ESCs_Mouse1.84600006
30SALL1_21062744_ChIP-ChIP_HESCs_Human1.78552727
31MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.77208702
32FLI1_27457419_Chip-Seq_LIVER_Mouse1.74364238
33SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.71088757
34SMAD4_21799915_ChIP-Seq_A2780_Human1.68569176
35ZFP57_27257070_Chip-Seq_ESCs_Mouse1.64414945
36NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.62667851
37ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.62525881
38CTBP2_25329375_ChIP-Seq_LNCAP_Human1.61053848
39STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.60921467
40TAF15_26573619_Chip-Seq_HEK293_Human1.60714413
41GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.60180087
42MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.57808488
43PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.56184347
44NR3C1_23031785_ChIP-Seq_PC12_Mouse1.52944369
45OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.52229208
46ESR1_20079471_ChIP-ChIP_T-47D_Human1.50471770
47ZNF274_21170338_ChIP-Seq_K562_Hela1.49128134
48P300_19829295_ChIP-Seq_ESCs_Human1.47338684
49ZNF217_24962896_ChIP-Seq_MCF-7_Human1.40802857
50STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.39238716
51CTBP1_25329375_ChIP-Seq_LNCAP_Human1.39221554
52EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.38271216
53AR_25329375_ChIP-Seq_VCAP_Human1.37013455
54SOX2_21211035_ChIP-Seq_LN229_Gbm1.36240627
55EZH2_27294783_Chip-Seq_NPCs_Mouse1.35117991
56TCF4_18268006_ChIP-ChIP_LS174T_Human1.33382730
57FLI1_21867929_ChIP-Seq_TH2_Mouse1.32456548
58CDX2_19796622_ChIP-Seq_MESCs_Mouse1.31996370
59RUNX_20019798_ChIP-Seq_JUKART_Human1.31124409
60TOP2B_26459242_ChIP-Seq_MCF-7_Human1.29688664
61AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.29133088
62SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29119542
63* STAT3_23295773_ChIP-Seq_U87_Human1.29066099
64TP53_16413492_ChIP-PET_HCT116_Human1.28004392
65CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.27639123
66PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.27621484
67* ARNT_22903824_ChIP-Seq_MCF-7_Human1.27521036
68POU3F2_20337985_ChIP-ChIP_501MEL_Human1.26723396
69IRF1_19129219_ChIP-ChIP_H3396_Human1.26361754
70SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25978280
71VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.25543338
72SMAD3_21741376_ChIP-Seq_EPCs_Human1.23218787
73* AR_19668381_ChIP-Seq_PC3_Human1.22742751
74PCGF2_27294783_Chip-Seq_ESCs_Mouse1.22164906
75FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.21332441
76WT1_25993318_ChIP-Seq_PODOCYTE_Human1.19765002
77RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.18306424
78MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.18124723
79TCF4_23295773_ChIP-Seq_U87_Human1.17300033
80* AHR_22903824_ChIP-Seq_MCF-7_Human1.17011232
81ERG_21242973_ChIP-ChIP_JURKAT_Human1.15689349
82SUZ12_27294783_Chip-Seq_NPCs_Mouse1.15470550
83EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.14683336
84SMAD_19615063_ChIP-ChIP_OVARY_Human1.14108428
85TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.13267117
86BCAT_22108803_ChIP-Seq_LS180_Human1.12905002
87CBX2_27304074_Chip-Seq_ESCs_Mouse1.12828789
88RING1B_27294783_Chip-Seq_ESCs_Mouse1.12067673
89TP53_22573176_ChIP-Seq_HFKS_Human1.11668077
90PIAS1_25552417_ChIP-Seq_VCAP_Human1.11325182
91FUS_26573619_Chip-Seq_HEK293_Human1.11048203
92TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10441784
93BMI1_23680149_ChIP-Seq_NPCS_Mouse1.08557329
94ELK4_26923725_Chip-Seq_MESODERM_Mouse1.08467340
95CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.08183995
96ER_23166858_ChIP-Seq_MCF-7_Human1.08115558
97ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.08105663
98YAP1_20516196_ChIP-Seq_MESCs_Mouse1.07547262
99P53_22387025_ChIP-Seq_ESCs_Mouse1.07510169
100CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.07213264
101CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07151365
102TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06989281
103NFE2_27457419_Chip-Seq_LIVER_Mouse1.06479364
104MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.04812985
105BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.03267188
106DNAJC2_21179169_ChIP-ChIP_NT2_Human1.03051264
107TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.02252975
108NOTCH1_21737748_ChIP-Seq_TLL_Human1.01836132
109LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01831478
110RUNX2_22187159_ChIP-Seq_PCA_Human1.01346485
111TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.00283831
112KLF5_20875108_ChIP-Seq_MESCs_Mouse1.00105325
113SMAD4_21741376_ChIP-Seq_HESCs_Human0.99960265
114TAL1_26923725_Chip-Seq_HPCs_Mouse0.99706925
115AUTS2_25519132_ChIP-Seq_293T-REX_Human0.99294964
116PRDM14_20953172_ChIP-Seq_ESCs_Human0.97742162
117TP53_18474530_ChIP-ChIP_U2OS_Human0.97493083
118POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.97354891
119TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97354891
120TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.97180998
121IGF1R_20145208_ChIP-Seq_DFB_Human0.96862007
122TBL1_22424771_ChIP-Seq_293T_Human0.96154971
123UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.95245100
124HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.94387182
125OCT4_21477851_ChIP-Seq_ESCs_Mouse0.93958873
126RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.93933507
127WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.93322687
128RING1B_27294783_Chip-Seq_NPCs_Mouse0.93315331
129WT1_19549856_ChIP-ChIP_CCG9911_Human0.93183823
130CTCF_18555785_Chip-Seq_ESCs_Mouse0.92379524
131SMAD4_21741376_ChIP-Seq_EPCs_Human0.92237091
132TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.91998423
133CRX_20693478_ChIP-Seq_RETINA_Mouse0.91960937
134SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.91460509
135RNF2_27304074_Chip-Seq_NSC_Mouse0.90494048
136NANOG_18555785_Chip-Seq_ESCs_Mouse0.90358165
137CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.89859270
138CBP_20019798_ChIP-Seq_JUKART_Human0.88689000
139IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.88689000
140* SMAD3_21741376_ChIP-Seq_ESCs_Human0.87674869
141NR3C1_21868756_ChIP-Seq_MCF10A_Human0.87337051
142EP300_21415370_ChIP-Seq_HL-1_Mouse0.87105181
143CTNNB1_20460455_ChIP-Seq_HCT116_Human0.86384741
144P53_22127205_ChIP-Seq_FIBROBLAST_Human0.83462651

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005257_abnormal_intraocular_pressure6.68995088
2MP0004859_abnormal_synaptic_plasticity5.15056317
3MP0003880_abnormal_central_pattern4.04424786
4MP0003635_abnormal_synaptic_transmissio3.73188760
5MP0008877_abnormal_DNA_methylation3.48114111
6MP0002063_abnormal_learning/memory/cond3.12589403
7MP0009745_abnormal_behavioral_response2.90614326
8MP0002102_abnormal_ear_morphology2.89784150
9MP0002064_seizures2.86727128
10MP0002572_abnormal_emotion/affect_behav2.82021135
11MP0004270_analgesia2.81357361
12MP0001968_abnormal_touch/_nociception2.75292598
13MP0002822_catalepsy2.58056569
14MP0001984_abnormal_olfaction2.40458403
15MP0002272_abnormal_nervous_system2.36898836
16MP0009780_abnormal_chondrocyte_physiolo2.34702617
17MP0009046_muscle_twitch2.32779527
18MP0005423_abnormal_somatic_nervous2.29145668
19MP0002734_abnormal_mechanical_nocicepti2.28289676
20MP0000613_abnormal_salivary_gland2.28104638
21MP0002736_abnormal_nociception_after2.27375441
22MP0001486_abnormal_startle_reflex2.26784081
23MP0002735_abnormal_chemical_nociception2.20669125
24MP0002909_abnormal_adrenal_gland2.20092055
25MP0003183_abnormal_peptide_metabolism2.19079956
26MP0004885_abnormal_endolymph2.10010190
27MP0003121_genomic_imprinting2.08429560
28MP0002938_white_spotting2.05533739
29MP0006276_abnormal_autonomic_nervous2.05353179
30MP0001501_abnormal_sleep_pattern1.93677139
31MP0005386_behavior/neurological_phenoty1.91924111
32MP0004924_abnormal_behavior1.91924111
33MP0003122_maternal_imprinting1.89334820
34MP0002067_abnormal_sensory_capabilities1.87180891
35MP0002557_abnormal_social/conspecific_i1.85298617
36MP0002653_abnormal_ependyma_morphology1.79359446
37MP0005645_abnormal_hypothalamus_physiol1.77115445
38MP0001970_abnormal_pain_threshold1.74728153
39MP0000778_abnormal_nervous_system1.74511968
40MP0005646_abnormal_pituitary_gland1.74408810
41MP0002733_abnormal_thermal_nociception1.72599214
42MP0008569_lethality_at_weaning1.69896835
43MP0001440_abnormal_grooming_behavior1.67650467
44MP0005253_abnormal_eye_physiology1.65099229
45MP0000013_abnormal_adipose_tissue1.64088447
46MP0004811_abnormal_neuron_physiology1.58172969
47MP0003329_amyloid_beta_deposits1.58106929
48MP0002184_abnormal_innervation1.54223388
49MP0001502_abnormal_circadian_rhythm1.51876575
50MP0003633_abnormal_nervous_system1.51253146
51MP0004858_abnormal_nervous_system1.47061113
52MP0003787_abnormal_imprinting1.34395597
53MP0002837_dystrophic_cardiac_calcinosis1.31693448
54MP0005248_abnormal_Harderian_gland1.30655203
55MP0002066_abnormal_motor_capabilities/c1.29404350
56MP0002177_abnormal_outer_ear1.29157643
57MP0003879_abnormal_hair_cell1.27088836
58MP0001986_abnormal_taste_sensitivity1.26688903
59MP0000465_gastrointestinal_hemorrhage1.26509893
60MP0002234_abnormal_pharynx_morphology1.25805498
61MP0003252_abnormal_bile_duct1.24919991
62MP0000955_abnormal_spinal_cord1.23803157
63MP0002882_abnormal_neuron_morphology1.23187858
64MP0001324_abnormal_eye_pigmentation1.23018535
65MP0002876_abnormal_thyroid_physiology1.22920168
66MP0001270_distended_abdomen1.21260455
67MP0005394_taste/olfaction_phenotype1.21230211
68MP0005499_abnormal_olfactory_system1.21230211
69MP0006292_abnormal_olfactory_placode1.19507773
70MP0001177_atelectasis1.13256629
71MP0010386_abnormal_urinary_bladder1.10934152
72MP0001529_abnormal_vocalization1.09782394
73MP0003631_nervous_system_phenotype1.09036935
74MP0005551_abnormal_eye_electrophysiolog1.08873028
75MP0008874_decreased_physiological_sensi1.08684970
76MP0004142_abnormal_muscle_tone1.08333740
77MP0005391_vision/eye_phenotype1.08026363
78MP0000516_abnormal_urinary_system1.07951738
79MP0005367_renal/urinary_system_phenotyp1.07951738
80MP0000015_abnormal_ear_pigmentation1.04783116
81MP0000631_abnormal_neuroendocrine_gland1.02525189
82MP0002928_abnormal_bile_duct1.02040843
83MP0002160_abnormal_reproductive_system0.99423314
84MP0002069_abnormal_eating/drinking_beha0.97306891
85MP0000569_abnormal_digit_pigmentation0.95517365
86MP0002152_abnormal_brain_morphology0.94807294
87MP0008872_abnormal_physiological_respon0.94499540
88MP0004043_abnormal_pH_regulation0.93675873
89MP0003724_increased_susceptibility_to0.90644092
90MP0003634_abnormal_glial_cell0.90410976
91MP0000538_abnormal_urinary_bladder0.89327535
92MP0002229_neurodegeneration0.88325104
93MP0000049_abnormal_middle_ear0.87918178
94MP0006054_spinal_hemorrhage0.87662480
95MP0002090_abnormal_vision0.86937498
96MP0000751_myopathy0.86911110
97MP0001905_abnormal_dopamine_level0.85823603
98MP0005535_abnormal_body_temperature0.84937750
99MP0008260_abnormal_autophagy0.84535827
100MP0000604_amyloidosis0.83856297
101MP0000428_abnormal_craniofacial_morphol0.83223632
102MP0001919_abnormal_reproductive_system0.81225736
103MP0008961_abnormal_basal_metabolism0.80674498
104MP0004742_abnormal_vestibular_system0.80215457
105MP0005075_abnormal_melanosome_morpholog0.79441664
106MP0003172_abnormal_lysosome_physiology0.79003094
107MP0003755_abnormal_palate_morphology0.78765347
108MP0004085_abnormal_heartbeat0.78504371
109MP0003690_abnormal_glial_cell0.73961228
110MP0003656_abnormal_erythrocyte_physiolo0.73732822
111MP0004147_increased_porphyrin_level0.73198983
112MP0000678_abnormal_parathyroid_gland0.72487297
113MP0008789_abnormal_olfactory_epithelium0.71908240
114MP0002638_abnormal_pupillary_reflex0.71069939
115MP0003221_abnormal_cardiomyocyte_apopto0.70217205
116MP0000920_abnormal_myelination0.69548321
117MP0002751_abnormal_autonomic_nervous0.69355123
118MP0006072_abnormal_retinal_apoptosis0.69192118
119MP0004133_heterotaxia0.68418427
120MP0001188_hyperpigmentation0.68268775
121MP0005389_reproductive_system_phenotype0.68169914
122MP0001963_abnormal_hearing_physiology0.67435463
123MP0002095_abnormal_skin_pigmentation0.67340369
124MP0004145_abnormal_muscle_electrophysio0.66207811
125MP0005084_abnormal_gallbladder_morpholo0.65542415
126MP0001664_abnormal_digestion0.65348472
127MP0002233_abnormal_nose_morphology0.64831290
128MP0005197_abnormal_uvea_morphology0.63317525
129MP0000681_abnormal_thyroid_gland0.63088906
130MP0003283_abnormal_digestive_organ0.62893007
131MP0003075_altered_response_to0.62214802
132MP0004484_altered_response_of0.61863864
133MP0002752_abnormal_somatic_nervous0.61831905
134MP0005410_abnormal_fertilization0.61251299
135MP0003935_abnormal_craniofacial_develop0.60976571
136MP0001943_abnormal_respiration0.60707980
137MP0010368_abnormal_lymphatic_system0.60587507
138MP0002078_abnormal_glucose_homeostasis0.60546285
139MP0005187_abnormal_penis_morphology0.59213493
140MP0005195_abnormal_posterior_eye0.59056559
141MP0003385_abnormal_body_wall0.56340181
142MP0003632_abnormal_nervous_system0.55384022
143MP0002282_abnormal_trachea_morphology0.53199617
144MP0002092_abnormal_eye_morphology0.52969295
145MP0008995_early_reproductive_senescence0.51913494
146MP0000163_abnormal_cartilage_morphology0.51806007
147MP0002108_abnormal_muscle_morphology0.51117870
148MP0000767_abnormal_smooth_muscle0.50307515
149MP0000003_abnormal_adipose_tissue0.48439110
150MP0003866_abnormal_defecation0.46913453
151MP0003011_delayed_dark_adaptation0.45915086
152MP0001542_abnormal_bone_strength0.45723697
153MP0002249_abnormal_larynx_morphology0.45459749
154MP0000372_irregular_coat_pigmentation0.44341616
155MP0008057_abnormal_DNA_replication0.43416657

Predicted human phenotypes

RankGene SetZ-score
1Aplasia/Hypoplasia of the fovea (HP:0008060)7.46786326
2Hypoplasia of the fovea (HP:0007750)7.46786326
3Abnormality of the fovea (HP:0000493)6.25632625
4Focal motor seizures (HP:0011153)5.82286259
5Myokymia (HP:0002411)5.41681970
6Aplasia/Hypoplasia of the macula (HP:0008059)5.13265366
7Difficulty running (HP:0009046)4.87146642
8Aplasia/Hypoplasia affecting the retina (HP:0008061)4.73941527
9Poor eye contact (HP:0000817)4.51027370
10Supranuclear gaze palsy (HP:0000605)4.37499319
11Focal seizures (HP:0007359)4.35459756
12Visual hallucinations (HP:0002367)4.09079404
13Impaired social interactions (HP:0000735)4.04858794
14Abnormal social behavior (HP:0012433)4.04858794
15Optic nerve coloboma (HP:0000588)4.03737953
16Hip dysplasia (HP:0001385)4.01213438
17Hyperventilation (HP:0002883)3.94699355
18Aplasia/Hypoplasia of the lens (HP:0008063)3.90424375
19Epileptic encephalopathy (HP:0200134)3.87044264
20Broad-based gait (HP:0002136)3.59905346
21Postural instability (HP:0002172)3.48536566
22Keratitis (HP:0000491)3.47598705
23Congenital primary aphakia (HP:0007707)3.43646083
24Febrile seizures (HP:0002373)3.40597375
25Nephrogenic diabetes insipidus (HP:0009806)3.38823027
26Atonic seizures (HP:0010819)3.26651891
27Tubulointerstitial nephritis (HP:0001970)3.25977546
28Long nose (HP:0003189)3.25420964
29Optic nerve hypoplasia (HP:0000609)3.24767581
30Papillary thyroid carcinoma (HP:0002895)3.19043571
31Progressive cerebellar ataxia (HP:0002073)3.16594582
32Absence seizures (HP:0002121)3.06759684
33Generalized tonic-clonic seizures (HP:0002069)2.97768272
34Thyroiditis (HP:0100646)2.90040099
35Anxiety (HP:0000739)2.89768628
36Ankle clonus (HP:0011448)2.89061900
37Excessive salivation (HP:0003781)2.87092653
38Drooling (HP:0002307)2.87092653
39Depression (HP:0000716)2.85846050
40Amyotrophic lateral sclerosis (HP:0007354)2.84166120
41Congenital glaucoma (HP:0001087)2.81125433
42Action tremor (HP:0002345)2.74143073
43Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.72802068
44Renal cortical cysts (HP:0000803)2.64819149
45Abnormality of the aortic arch (HP:0012303)2.61711509
46Truncal ataxia (HP:0002078)2.61639558
47Fair hair (HP:0002286)2.59483784
48Dialeptic seizures (HP:0011146)2.58394496
49Blue irides (HP:0000635)2.57275218
50Poor coordination (HP:0002370)2.57089021
51Gait ataxia (HP:0002066)2.55831345
52Abnormality of the lower motor neuron (HP:0002366)2.54331925
53Nephronophthisis (HP:0000090)2.54152736
54Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.50534866
55Mask-like facies (HP:0000298)2.50110276
56Pheochromocytoma (HP:0002666)2.48015658
57Epileptiform EEG discharges (HP:0011182)2.46781486
58Hip contracture (HP:0003273)2.45892047
59Spastic gait (HP:0002064)2.45799701
60Prolonged QT interval (HP:0001657)2.45208820
61True hermaphroditism (HP:0010459)2.44280490
62Mutism (HP:0002300)2.43861783
63Protruding tongue (HP:0010808)2.43058064
64Scanning speech (HP:0002168)2.42430936
65EEG with generalized epileptiform discharges (HP:0011198)2.41177674
66Abnormal respiratory epithelium morphology (HP:0012253)2.40203484
67Abnormal respiratory motile cilium morphology (HP:0005938)2.40203484
68Impaired vibration sensation in the lower limbs (HP:0002166)2.37290835
69Agitation (HP:0000713)2.37136428
70Severe combined immunodeficiency (HP:0004430)2.37016079
71Abnormal eating behavior (HP:0100738)2.35844774
72Generalized hypopigmentation of hair (HP:0011358)2.35742201
73Tetraplegia (HP:0002445)2.35655432
74Abnormality of eosinophils (HP:0001879)2.35045218
75Large eyes (HP:0001090)2.28340232
76Absent speech (HP:0001344)2.27354008
77Dynein arm defect of respiratory motile cilia (HP:0012255)2.27335267
78Absent/shortened dynein arms (HP:0200106)2.27335267
79Abnormality of the renal cortex (HP:0011035)2.23661359
80Impaired smooth pursuit (HP:0007772)2.22156706
81Abnormal EKG (HP:0003115)2.21657689
82Prominent supraorbital ridges (HP:0000336)2.21213510
83Hypsarrhythmia (HP:0002521)2.20417612
84Pancreatic fibrosis (HP:0100732)2.19813284
85Bradykinesia (HP:0002067)2.19233544
86Abnormal protein glycosylation (HP:0012346)2.17073426
87Abnormal glycosylation (HP:0012345)2.17073426
88Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.17073426
89Abnormal protein N-linked glycosylation (HP:0012347)2.17073426
90Genital tract atresia (HP:0001827)2.17001704
91Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.15678551
92Abnormality of the renal medulla (HP:0100957)2.14151524
93Papilledema (HP:0001085)2.14107853
94Dysmetria (HP:0001310)2.13648367
95Stereotypic behavior (HP:0000733)2.13529823
96Menstrual irregularities (HP:0000858)2.12325023
97Vaginal atresia (HP:0000148)2.09398325
98Insomnia (HP:0100785)2.09169630
99Pachygyria (HP:0001302)2.09155470
100Dysdiadochokinesis (HP:0002075)2.08210805
101Thyroid carcinoma (HP:0002890)2.07588344
102Pancreatic cysts (HP:0001737)2.07339693
103Urinary bladder sphincter dysfunction (HP:0002839)2.07061603
104Inability to walk (HP:0002540)2.06885708
105Polyphagia (HP:0002591)2.06213396
106Torticollis (HP:0000473)2.05414903
107Lissencephaly (HP:0001339)2.04775417
108Rigidity (HP:0002063)2.02604036
109Abnormality of salivation (HP:0100755)2.01560737
110Neuroendocrine neoplasm (HP:0100634)2.01195562
111Psychosis (HP:0000709)2.00734285
112Specific learning disability (HP:0001328)2.00260114
113Hypoventilation (HP:0002791)1.99117967
114Corneal dystrophy (HP:0001131)1.98850705
115Abnormality of ocular smooth pursuit (HP:0000617)1.98632665
116Autism (HP:0000717)1.97087294
117Dyskinesia (HP:0100660)1.96495869
118Neurofibrillary tangles (HP:0002185)1.96133630
119Rhinitis (HP:0012384)1.95727197
120Urinary urgency (HP:0000012)1.94759077
121Cerebral inclusion bodies (HP:0100314)1.93537032
122Absent rod-and cone-mediated responses on ERG (HP:0007688)1.92935077
123Tubulointerstitial abnormality (HP:0001969)1.92885921
124Status epilepticus (HP:0002133)1.92682739
125Progressive inability to walk (HP:0002505)1.91926128
126Hemiplegia (HP:0002301)1.91699433
127Athetosis (HP:0002305)1.91527409
128Decreased circulating renin level (HP:0003351)1.91271490
129Failure to thrive in infancy (HP:0001531)1.89551564
130Intention tremor (HP:0002080)1.89481508
131Scrotal hypoplasia (HP:0000046)1.88480805
132Lower limb muscle weakness (HP:0007340)1.87526981
133Macroorchidism (HP:0000053)1.87479915
134Macular degeneration (HP:0000608)1.86720949
135Abnormal hair whorl (HP:0010721)1.86023188
136Abnormal ciliary motility (HP:0012262)1.84474768
137Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.84412797
138Tented upper lip vermilion (HP:0010804)1.84284374
139Attenuation of retinal blood vessels (HP:0007843)1.84131635
140Spinal canal stenosis (HP:0003416)1.83474440
141Postaxial foot polydactyly (HP:0001830)1.82726458
142Gaze-evoked nystagmus (HP:0000640)1.82211369
143Progressive microcephaly (HP:0000253)1.81573506
144Occipital encephalocele (HP:0002085)1.81565204
145Recurrent sinusitis (HP:0011108)1.80743326
146Decreased central vision (HP:0007663)1.80387261
147Growth hormone deficiency (HP:0000824)1.79446727
148Short foot (HP:0001773)1.78986373
149Astigmatism (HP:0000483)1.77329578
150Focal dystonia (HP:0004373)1.77280008
151Exotropia (HP:0000577)1.76800789
152Bronchomalacia (HP:0002780)1.76696614
153Spastic tetraplegia (HP:0002510)1.75943268
154Broad foot (HP:0001769)1.75881214
155Growth hormone excess (HP:0000845)1.75530286
156Gait imbalance (HP:0002141)1.75423383
157Congenital hepatic fibrosis (HP:0002612)1.75410580
158Postaxial hand polydactyly (HP:0001162)1.75213112
159Medulloblastoma (HP:0002885)1.74508777
160Widely spaced teeth (HP:0000687)1.73489791
161Megalencephaly (HP:0001355)1.72591432
162Abnormal respiratory motile cilium physiology (HP:0012261)1.72045000
163Type I transferrin isoform profile (HP:0003642)1.71227969
164Elfin facies (HP:0004428)1.71141437
165Chronic hepatic failure (HP:0100626)1.70858636
166Atrophy/Degeneration involving motor neurons (HP:0007373)1.70196474
167Aplasia/Hypoplasia of the tibia (HP:0005772)1.70093898
168Autoamputation (HP:0001218)1.69562300
169Ketoacidosis (HP:0001993)1.67576409
170Open mouth (HP:0000194)1.67453006
171Polar cataract (HP:0010696)1.67441379
172Medial flaring of the eyebrow (HP:0010747)1.67326621
173Amblyopia (HP:0000646)1.67078603
174Abnormality of secondary sexual hair (HP:0009888)1.66741704
175Abnormality of the axillary hair (HP:0100134)1.66741704
176Palpebral edema (HP:0100540)1.66463197
177Aplasia/Hypoplasia of the brainstem (HP:0007362)1.65864140
178Hypoplasia of the brainstem (HP:0002365)1.65864140

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK35.21804491
2EPHA43.91739227
3TAOK33.60994044
4MAP3K42.91752882
5BCR2.88136979
6INSRR2.74010286
7MARK12.69070612
8CASK2.59237066
9MAP3K92.51371323
10EPHA32.41480602
11MAP2K72.34942613
12FRK2.32729873
13MINK12.22025329
14BCKDK2.18048738
15PRKD32.02644297
16NTRK22.00217589
17CAMKK21.82318892
18LMTK21.80739329
19PIM21.77333880
20MAP3K121.74990011
21DAPK21.73405443
22TESK21.73172786
23PAK61.72710498
24BRD41.70886266
25MAP4K21.68595746
26SRPK11.67352792
27CAMKK11.63128668
28MAP2K41.62961445
29MAPK131.60121027
30EPHB11.55781397
31CSNK1A1L1.49982719
32SGK2231.49693205
33SGK4941.49693205
34UHMK11.47602399
35CSNK1G31.39495531
36LATS11.38448128
37GRK11.38303857
38SGK21.37093168
39PHKG21.35479284
40PHKG11.35479284
41CDK51.34520544
42RIPK41.32465386
43SIK21.32158156
44TNIK1.31913591
45TRIM281.31507887
46CDK31.23239405
47NTRK11.22687141
48KSR11.16694967
49PRKCH1.15295418
50CDK121.14255106
51MAPKAPK51.12609429
52SGK31.11785870
53FES1.09213671
54KSR21.03646390
55PRKCG1.03315785
56CAMK1G1.03178429
57DAPK11.01952346
58PAK31.00245547
59PLK20.98164693
60ERBB30.97316964
61RAF10.95460642
62CAMK10.93258394
63CSNK1G10.91558508
64PINK10.91167976
65CAMK2A0.90824176
66DYRK1B0.89869198
67NEK90.89474940
68TESK10.89235855
69CDK190.88491432
70AKT30.88079043
71DYRK1A0.86399484
72WNK10.83689036
73PTK2B0.83186230
74GRK50.82847382
75MAP3K50.82509380
76PIK3CA0.81229665
77ICK0.80977098
78MAP3K130.80665713
79MARK20.79032881
80STK380.78968446
81GRK60.78784085
82CAMK2B0.78663579
83MAPK70.78024010
84STK38L0.76037781
85ADRBK20.74724095
86MAP3K20.73764306
87RPS6KA40.73599196
88ERN10.72256812
89PRKCE0.71613138
90PRPF4B0.70328617
91CAMK40.69557720
92SIK30.69122365
93MAP3K60.67474744
94SGK10.65315617
95RET0.63920122
96BMPR1B0.62326376
97LIMK10.61661643
98CDK140.61129799
99MAPK150.60512380
100CDK180.59423146
101WNK30.59305062
102CSNK1G20.58142440
103FER0.58121827
104RPS6KA20.58067837
105CDK150.56197011
106PRKD20.55586050
107RPS6KA30.54212498
108DYRK20.53767772
109PNCK0.52499365
110NEK60.49949139
111FYN0.49727887
112JAK10.49335202
113JAK20.49212256
114MAPK110.48877351
115MAP3K70.48513696
116PRKCZ0.48101966
117PRKAA10.47643220
118BMPR20.47169520
119OXSR10.46075694
120CSNK1D0.45893196
121MAP3K110.45727351
122RPS6KA50.45052061
123STK110.44073846
124WNK40.43612145
125PRKG10.43524790
126CDK60.42550691
127CDK11A0.42279343
128PDGFRA0.41787236
129CAMK2G0.41437110
130ADRBK10.40909578
131CCNB10.40845563
132PDK10.40601880
133CAMK2D0.40552741
134CAMK1D0.40516086
135IRAK20.40416932
136LCK0.39917023
137PRKCA0.39776703
138CDC42BPA0.38089780
139PRKACA0.37426181
140SCYL20.36945847
141IKBKE0.36830282
142SRC0.36701219
143MAP2K10.36509976
144SIK10.36498512
145PRKD10.35900198
146HIPK20.35748199
147PRKCB0.35572440
148PIK3CG0.34985137
149CSNK1A10.34976495
150TYK20.34945851
151TXK0.34142133
152ZAP700.33375228

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.19722274
2Synaptic vesicle cycle_Homo sapiens_hsa047212.78800002
3Circadian entrainment_Homo sapiens_hsa047132.62151807
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.56090045
5GABAergic synapse_Homo sapiens_hsa047272.53429044
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.44610060
7Insulin secretion_Homo sapiens_hsa049112.42876982
8Morphine addiction_Homo sapiens_hsa050322.42240593
9Long-term potentiation_Homo sapiens_hsa047202.36709029
10Glutamatergic synapse_Homo sapiens_hsa047242.32695496
11Amphetamine addiction_Homo sapiens_hsa050312.30250053
12Olfactory transduction_Homo sapiens_hsa047402.28830418
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.01921331
14Salivary secretion_Homo sapiens_hsa049701.99946383
15Aldosterone synthesis and secretion_Homo sapiens_hsa049251.97369834
16Dopaminergic synapse_Homo sapiens_hsa047281.95408805
17Gastric acid secretion_Homo sapiens_hsa049711.90030742
18Taste transduction_Homo sapiens_hsa047421.84606427
19Cholinergic synapse_Homo sapiens_hsa047251.79307638
20Renin secretion_Homo sapiens_hsa049241.79288380
21Cocaine addiction_Homo sapiens_hsa050301.79070428
22Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.69884228
23Fatty acid biosynthesis_Homo sapiens_hsa000611.69134478
24Serotonergic synapse_Homo sapiens_hsa047261.61018646
25RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.58189211
26Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.50171039
27Calcium signaling pathway_Homo sapiens_hsa040201.45978559
28Regulation of autophagy_Homo sapiens_hsa041401.44841603
29Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.43966820
30Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.38261973
31mTOR signaling pathway_Homo sapiens_hsa041501.37551823
32Oxytocin signaling pathway_Homo sapiens_hsa049211.36538412
33Long-term depression_Homo sapiens_hsa047301.32875672
34GnRH signaling pathway_Homo sapiens_hsa049121.29644358
35Type II diabetes mellitus_Homo sapiens_hsa049301.27027350
36Primary immunodeficiency_Homo sapiens_hsa053401.26730804
37Glycosaminoglycan degradation_Homo sapiens_hsa005311.22833446
38Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.22577528
39cAMP signaling pathway_Homo sapiens_hsa040241.22063588
40Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.20673119
41Nitrogen metabolism_Homo sapiens_hsa009101.18121054
42Collecting duct acid secretion_Homo sapiens_hsa049661.16948818
43Phosphatidylinositol signaling system_Homo sapiens_hsa040701.16120276
44Axon guidance_Homo sapiens_hsa043601.09803298
45Vibrio cholerae infection_Homo sapiens_hsa051101.07151274
46Gap junction_Homo sapiens_hsa045401.06562763
47Pancreatic secretion_Homo sapiens_hsa049721.03660669
48Phenylalanine metabolism_Homo sapiens_hsa003601.02312963
49Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.01644661
50Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.01472558
51Estrogen signaling pathway_Homo sapiens_hsa049151.00313205
52Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.97962441
53cGMP-PKG signaling pathway_Homo sapiens_hsa040220.94808148
54Peroxisome_Homo sapiens_hsa041460.94124404
55Vascular smooth muscle contraction_Homo sapiens_hsa042700.93593601
56Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.92897086
57Thyroid hormone synthesis_Homo sapiens_hsa049180.90849672
58Bile secretion_Homo sapiens_hsa049760.90447291
59Hepatitis B_Homo sapiens_hsa051610.89414785
60Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.86938123
61Glucagon signaling pathway_Homo sapiens_hsa049220.84899484
62Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.84004369
63Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.80423797
64Melanogenesis_Homo sapiens_hsa049160.79249141
65Transcriptional misregulation in cancer_Homo sapiens_hsa052020.78271819
66Glioma_Homo sapiens_hsa052140.78095507
67Maturity onset diabetes of the young_Homo sapiens_hsa049500.78009955
68Other glycan degradation_Homo sapiens_hsa005110.77514215
69Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.76290949
70Shigellosis_Homo sapiens_hsa051310.76277297
71Dilated cardiomyopathy_Homo sapiens_hsa054140.75517721
72Inositol phosphate metabolism_Homo sapiens_hsa005620.73091613
73FoxO signaling pathway_Homo sapiens_hsa040680.72837972
74Cardiac muscle contraction_Homo sapiens_hsa042600.72269858
75Carbohydrate digestion and absorption_Homo sapiens_hsa049730.72200183
76Jak-STAT signaling pathway_Homo sapiens_hsa046300.71562035
77Colorectal cancer_Homo sapiens_hsa052100.70682692
78Measles_Homo sapiens_hsa051620.70458898
79Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.67540814
80Herpes simplex infection_Homo sapiens_hsa051680.67259252
81Circadian rhythm_Homo sapiens_hsa047100.66517665
82Ovarian steroidogenesis_Homo sapiens_hsa049130.66429459
83Prolactin signaling pathway_Homo sapiens_hsa049170.65938968
84Hepatitis C_Homo sapiens_hsa051600.64595835
85Phototransduction_Homo sapiens_hsa047440.61863391
86Osteoclast differentiation_Homo sapiens_hsa043800.60092260
87Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.59911543
88Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.59034818
89ErbB signaling pathway_Homo sapiens_hsa040120.59001899
90Butanoate metabolism_Homo sapiens_hsa006500.58789503
91MAPK signaling pathway_Homo sapiens_hsa040100.58453521
92Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.58322383
93Thyroid hormone signaling pathway_Homo sapiens_hsa049190.58010502
94Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.57897849
95Pentose phosphate pathway_Homo sapiens_hsa000300.57792422
96Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.57201843
97Phagosome_Homo sapiens_hsa041450.56659972
98Phospholipase D signaling pathway_Homo sapiens_hsa040720.55326665
99Fanconi anemia pathway_Homo sapiens_hsa034600.54967947
100Tuberculosis_Homo sapiens_hsa051520.54715446
101Dorso-ventral axis formation_Homo sapiens_hsa043200.54646652
102Fatty acid elongation_Homo sapiens_hsa000620.54058641
103N-Glycan biosynthesis_Homo sapiens_hsa005100.54037374
104Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.53621037
105Rap1 signaling pathway_Homo sapiens_hsa040150.53204654
106Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.52583448
107Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.50914714
108SNARE interactions in vesicular transport_Homo sapiens_hsa041300.50427610
109Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.50381158
110Neurotrophin signaling pathway_Homo sapiens_hsa047220.50205146
111Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.49895675
112Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.49249258
113Sphingolipid signaling pathway_Homo sapiens_hsa040710.48189040
114Adipocytokine signaling pathway_Homo sapiens_hsa049200.48068558
115Type I diabetes mellitus_Homo sapiens_hsa049400.47080875
116Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.46729321
117B cell receptor signaling pathway_Homo sapiens_hsa046620.45952679
118Prion diseases_Homo sapiens_hsa050200.45356683
119Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.45185280
120Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.44728838
121NF-kappa B signaling pathway_Homo sapiens_hsa040640.44618736
122Ras signaling pathway_Homo sapiens_hsa040140.44080079
123Pancreatic cancer_Homo sapiens_hsa052120.43670344
124Choline metabolism in cancer_Homo sapiens_hsa052310.43064043
125TGF-beta signaling pathway_Homo sapiens_hsa043500.42760754
126Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.42424894
127beta-Alanine metabolism_Homo sapiens_hsa004100.42173918
128Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.41909867
129ABC transporters_Homo sapiens_hsa020100.40966001
130Sulfur metabolism_Homo sapiens_hsa009200.40458039
131Arginine biosynthesis_Homo sapiens_hsa002200.40387046
132Insulin signaling pathway_Homo sapiens_hsa049100.38581293
133Ether lipid metabolism_Homo sapiens_hsa005650.37350473
134Longevity regulating pathway - mammal_Homo sapiens_hsa042110.36033617
135Alzheimers disease_Homo sapiens_hsa050100.35971677
136Endocytosis_Homo sapiens_hsa041440.35137352
137Oocyte meiosis_Homo sapiens_hsa041140.33285569
138Fatty acid metabolism_Homo sapiens_hsa012120.32688977
139VEGF signaling pathway_Homo sapiens_hsa043700.29396555
140Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.27336463
141Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.25878059
142Tryptophan metabolism_Homo sapiens_hsa003800.25739385
143Alcoholism_Homo sapiens_hsa050340.24654343
144Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.24325270
145Insulin resistance_Homo sapiens_hsa049310.23363538

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