FAM120C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a potential transmembrane protein and lies in a region where mutations and deletions have been associated with intellectual disability and autism. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.39260497
2synaptic vesicle maturation (GO:0016188)5.31882444
3locomotory exploration behavior (GO:0035641)5.23493128
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.11916271
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.89739058
6synaptic vesicle exocytosis (GO:0016079)4.57047574
7tachykinin receptor signaling pathway (GO:0007217)4.48281143
8regulation of synaptic vesicle exocytosis (GO:2000300)4.46939182
9glutamate secretion (GO:0014047)4.42637615
10vocalization behavior (GO:0071625)4.39092580
11regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.26053219
12neuronal action potential propagation (GO:0019227)4.24201879
13dendritic spine morphogenesis (GO:0060997)4.19183453
14serotonin metabolic process (GO:0042428)4.13241735
15regulation of hippo signaling (GO:0035330)4.09533316
16synaptic vesicle docking involved in exocytosis (GO:0016081)4.06825946
17regulation of glutamate receptor signaling pathway (GO:1900449)4.01877109
18regulation of synaptic vesicle transport (GO:1902803)3.95146601
19membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.94773470
20layer formation in cerebral cortex (GO:0021819)3.91651820
21protein localization to synapse (GO:0035418)3.91122354
22regulation of synapse structural plasticity (GO:0051823)3.90714991
23regulation of neuronal synaptic plasticity (GO:0048168)3.88654151
24regulation of long-term neuronal synaptic plasticity (GO:0048169)3.88381085
25behavioral response to nicotine (GO:0035095)3.84062201
26neurotransmitter secretion (GO:0007269)3.82667238
27neuron cell-cell adhesion (GO:0007158)3.80426202
28cellular potassium ion homeostasis (GO:0030007)3.77808619
29exploration behavior (GO:0035640)3.77408976
30ionotropic glutamate receptor signaling pathway (GO:0035235)3.77090455
31detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.70560787
32primary amino compound metabolic process (GO:1901160)3.66463155
33synaptic transmission, glutamatergic (GO:0035249)3.64867637
34sodium ion export (GO:0071436)3.63259980
35negative regulation of protein localization to cell surface (GO:2000009)3.58136404
36auditory behavior (GO:0031223)3.56310713
37activation of protein kinase A activity (GO:0034199)3.52030792
38innervation (GO:0060384)3.51262800
39long-term memory (GO:0007616)3.51145783
40gamma-aminobutyric acid transport (GO:0015812)3.49877079
41neurotransmitter-gated ion channel clustering (GO:0072578)3.49235484
42proline transport (GO:0015824)3.48061605
43cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.47794606
44neuron-neuron synaptic transmission (GO:0007270)3.44543217
45histone H2A acetylation (GO:0043968)3.42675515
46indole-containing compound metabolic process (GO:0042430)3.42476329
47glutamate receptor signaling pathway (GO:0007215)3.39714120
48neuronal action potential (GO:0019228)3.35023718
49response to auditory stimulus (GO:0010996)3.33316087
50cerebellar Purkinje cell differentiation (GO:0021702)3.33291367
51regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.31147770
52positive regulation of membrane potential (GO:0045838)3.30632153
53central nervous system myelination (GO:0022010)3.30160286
54axon ensheathment in central nervous system (GO:0032291)3.30160286
55regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.26917707
56axonal fasciculation (GO:0007413)3.26646199
57dendrite morphogenesis (GO:0048813)3.26633568
58cell communication by electrical coupling (GO:0010644)3.26469465
59detection of light stimulus involved in visual perception (GO:0050908)3.26400996
60detection of light stimulus involved in sensory perception (GO:0050962)3.26400996
61regulation of excitatory postsynaptic membrane potential (GO:0060079)3.21912656
62peristalsis (GO:0030432)3.21429613
63neuronal ion channel clustering (GO:0045161)3.20433048
64positive regulation of uterine smooth muscle contraction (GO:0070474)3.18353948
65positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.17158412
66interkinetic nuclear migration (GO:0022027)3.17116488
67reflex (GO:0060004)3.17000268
68neurotransmitter transport (GO:0006836)3.16304122
69neuron recognition (GO:0008038)3.15335716
70regulation of ARF protein signal transduction (GO:0032012)3.14721836
71positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.14178187
72righting reflex (GO:0060013)3.13622882
73negative regulation of cytosolic calcium ion concentration (GO:0051481)3.12999520
74positive regulation of synaptic transmission, GABAergic (GO:0032230)3.10926694
75regulation of postsynaptic membrane potential (GO:0060078)3.10123332
76long-term synaptic potentiation (GO:0060291)3.09627080
77protein K48-linked deubiquitination (GO:0071108)3.08013077
78transmission of nerve impulse (GO:0019226)3.07443586
79regulation of synaptic plasticity (GO:0048167)3.06714229
80neuromuscular process controlling balance (GO:0050885)3.05949381
81regulation of dendritic spine morphogenesis (GO:0061001)3.05717063
82regulation of neurotransmitter uptake (GO:0051580)3.02769395
83startle response (GO:0001964)3.01890836
84prepulse inhibition (GO:0060134)2.99823360
85synaptic vesicle endocytosis (GO:0048488)2.97353424
86membrane depolarization during action potential (GO:0086010)2.97080618
87dendritic spine organization (GO:0097061)2.96027900
88positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.95798040
89regulation of vesicle fusion (GO:0031338)2.95618565
90chemosensory behavior (GO:0007635)2.94067336
91opioid receptor signaling pathway (GO:0038003)2.92922118
92regulation of synaptic transmission, glutamatergic (GO:0051966)2.92778116
93auditory receptor cell stereocilium organization (GO:0060088)2.92492547
94mechanosensory behavior (GO:0007638)2.92037389
95cerebellar Purkinje cell layer development (GO:0021680)2.90807008
96regulation of neurotransmitter secretion (GO:0046928)2.89339113
97potassium ion import (GO:0010107)2.89031026
98negative regulation of cAMP-mediated signaling (GO:0043951)2.88964815
99positive regulation of CREB transcription factor activity (GO:0032793)2.88684813
100detection of mechanical stimulus involved in sensory perception (GO:0050974)2.86818893
101nerve growth factor signaling pathway (GO:0038180)2.86813062
102gamma-aminobutyric acid signaling pathway (GO:0007214)2.85916834
103glycine transport (GO:0015816)2.85692989
104cilium or flagellum-dependent cell motility (GO:0001539)2.85632608
105regulation of neurotransmitter levels (GO:0001505)2.84800981
106regulation of pigment cell differentiation (GO:0050932)2.83529652
107cellular potassium ion transport (GO:0071804)2.82220522
108potassium ion transmembrane transport (GO:0071805)2.82220522
109synapse assembly (GO:0007416)2.81704109
110neuromuscular process controlling posture (GO:0050884)2.81053858
111regulation of skeletal muscle contraction (GO:0014819)2.80576530
112phasic smooth muscle contraction (GO:0014821)2.79259233
113potassium ion homeostasis (GO:0055075)2.78128831
114synapse organization (GO:0050808)2.77637540
115postsynaptic membrane organization (GO:0001941)2.76949835
116membrane hyperpolarization (GO:0060081)2.75616560
117establishment of nucleus localization (GO:0040023)2.75355261
118presynaptic membrane assembly (GO:0097105)2.75243401
119G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.75137656
120membrane depolarization (GO:0051899)2.74029631
121regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.73846947
122negative regulation of systemic arterial blood pressure (GO:0003085)2.73515096
123positive regulation of potassium ion transmembrane transport (GO:1901381)2.73413984
124behavioral response to ethanol (GO:0048149)2.72819967
125vesicle transport along microtubule (GO:0047496)2.72623958
126regulation of calcium ion-dependent exocytosis (GO:0017158)2.71408137
127regulation of neurotransmitter transport (GO:0051588)2.69930973
128positive regulation of synapse maturation (GO:0090129)2.68187126
129positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.67116444
130negative regulation of synaptic transmission, GABAergic (GO:0032229)2.66123839
131cerebellar granule cell differentiation (GO:0021707)2.66086333
132learning (GO:0007612)2.65990270
133positive regulation of developmental pigmentation (GO:0048087)2.65647041
134urate metabolic process (GO:0046415)2.65375338
135positive regulation of dendritic spine development (GO:0060999)2.64716195
136detection of calcium ion (GO:0005513)2.64048503
137positive regulation of synaptic transmission (GO:0050806)2.63116919
138positive regulation of potassium ion transport (GO:0043268)2.61211188
139intraspecies interaction between organisms (GO:0051703)2.61092255
140snRNA transcription (GO:0009301)2.59111646
141cellular ketone body metabolic process (GO:0046950)2.58829787
142alanine transport (GO:0032328)2.58793751
143peptidyl-tyrosine autophosphorylation (GO:0038083)2.57551540
144potassium ion transport (GO:0006813)2.57297845
145negative regulation of neurotransmitter transport (GO:0051589)2.57187513
146photoreceptor cell maintenance (GO:0045494)2.54892643
147multicellular organismal movement (GO:0050879)2.52164191
148musculoskeletal movement (GO:0050881)2.52164191
149dermatan sulfate biosynthetic process (GO:0030208)2.51778150
150presynaptic membrane organization (GO:0097090)2.51051138
151regulation of uterine smooth muscle contraction (GO:0070472)2.50823407
152meiotic chromosome segregation (GO:0045132)2.49710454
153histone H4-K12 acetylation (GO:0043983)2.49314126
154phosphate ion transport (GO:0006817)2.48802723
155inner ear receptor stereocilium organization (GO:0060122)2.46329448
156positive regulation of meiosis (GO:0045836)2.44685810
157gonadal mesoderm development (GO:0007506)2.44164041
158DNA methylation involved in gamete generation (GO:0043046)2.42635246
159ketone body metabolic process (GO:1902224)2.39816028
160behavioral response to cocaine (GO:0048148)2.39134202
161regulation of respiratory system process (GO:0044065)2.39085024
162positive regulation of action potential (GO:0045760)2.38111071
163rhodopsin mediated signaling pathway (GO:0016056)2.37706203
164cAMP catabolic process (GO:0006198)2.36835894
165positive regulation of fatty acid oxidation (GO:0046321)2.36531561
166cell morphogenesis involved in neuron differentiation (GO:0048667)2.36108096
167endosome to melanosome transport (GO:0035646)2.35898461
168endosome to pigment granule transport (GO:0043485)2.35898461
169lipid translocation (GO:0034204)2.35307908
170phospholipid translocation (GO:0045332)2.35307908
171protein K63-linked deubiquitination (GO:0070536)2.34769053
172regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.33297290
173regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.33297290
174regulation of rhodopsin mediated signaling pathway (GO:0022400)2.32338336
175appendage development (GO:0048736)2.32320386
176limb development (GO:0060173)2.32320386
177indolalkylamine metabolic process (GO:0006586)2.30678848
178nonmotile primary cilium assembly (GO:0035058)2.30387775
179central nervous system neuron axonogenesis (GO:0021955)2.30226651

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.07995054
2GBX2_23144817_ChIP-Seq_PC3_Human3.38975583
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.91561756
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.90380755
5GATA1_22025678_ChIP-Seq_K562_Human2.79710757
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.74073712
7DROSHA_22980978_ChIP-Seq_HELA_Human2.64066646
8RARB_27405468_Chip-Seq_BRAIN_Mouse2.51511752
9VDR_22108803_ChIP-Seq_LS180_Human2.51194426
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.51104382
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.51104382
12REST_21632747_ChIP-Seq_MESCs_Mouse2.46504902
13MTF2_20144788_ChIP-Seq_MESCs_Mouse2.46366393
14SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.43381775
15JARID2_20075857_ChIP-Seq_MESCs_Mouse2.40926696
16SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.33889492
17ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.29373265
18SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.28883469
19SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.28515716
20EZH2_27304074_Chip-Seq_ESCs_Mouse2.28084836
21RNF2_27304074_Chip-Seq_ESCs_Mouse2.10667350
22EZH2_27294783_Chip-Seq_ESCs_Mouse2.10512964
23EED_16625203_ChIP-ChIP_MESCs_Mouse2.09852621
24SUZ12_27294783_Chip-Seq_ESCs_Mouse2.09564106
25REST_18959480_ChIP-ChIP_MESCs_Mouse2.05679530
26FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.05165038
27AR_21572438_ChIP-Seq_LNCaP_Human1.95588489
28CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.90172962
29GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.89825902
30MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.85781435
31ER_23166858_ChIP-Seq_MCF-7_Human1.85509100
32EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.82058845
33FUS_26573619_Chip-Seq_HEK293_Human1.81928778
34SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.75159029
35RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.74839878
36CTBP2_25329375_ChIP-Seq_LNCAP_Human1.68787622
37SMAD4_21799915_ChIP-Seq_A2780_Human1.64056629
38BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.61237449
39IKZF1_21737484_ChIP-ChIP_HCT116_Human1.52255964
40CTBP1_25329375_ChIP-Seq_LNCAP_Human1.52179561
41NR3C1_23031785_ChIP-Seq_PC12_Mouse1.48449496
42UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.47738345
43SALL1_21062744_ChIP-ChIP_HESCs_Human1.47605203
44PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.46725753
45SOX2_21211035_ChIP-Seq_LN229_Gbm1.44546239
46ZNF274_21170338_ChIP-Seq_K562_Hela1.39063462
47AR_19668381_ChIP-Seq_PC3_Human1.37904448
48STAT3_23295773_ChIP-Seq_U87_Human1.37363678
49CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36166254
50WT1_25993318_ChIP-Seq_PODOCYTE_Human1.36098371
51TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35199569
52POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.35199569
53ERG_21242973_ChIP-ChIP_JURKAT_Human1.34299893
54EWS_26573619_Chip-Seq_HEK293_Human1.33959760
55PIAS1_25552417_ChIP-Seq_VCAP_Human1.33127623
56NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.32504572
57BCAT_22108803_ChIP-Seq_LS180_Human1.31724727
58ZNF217_24962896_ChIP-Seq_MCF-7_Human1.31664189
59TAF15_26573619_Chip-Seq_HEK293_Human1.31625500
60FLI1_27457419_Chip-Seq_LIVER_Mouse1.31313086
61SMAD3_21741376_ChIP-Seq_EPCs_Human1.29499156
62TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.28565646
63SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.28406849
64RING1B_27294783_Chip-Seq_ESCs_Mouse1.27369302
65RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.25830993
66PRDM14_20953172_ChIP-Seq_ESCs_Human1.24088204
67OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24006220
68YAP1_20516196_ChIP-Seq_MESCs_Mouse1.22336654
69P300_19829295_ChIP-Seq_ESCs_Human1.22234269
70PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.21321022
71ZFP57_27257070_Chip-Seq_ESCs_Mouse1.20341343
72WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.20201250
73FLI1_21867929_ChIP-Seq_TH2_Mouse1.20166188
74AR_25329375_ChIP-Seq_VCAP_Human1.20110624
75KDM2B_26808549_Chip-Seq_REH_Human1.20007172
76AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.19151785
77ARNT_22903824_ChIP-Seq_MCF-7_Human1.18874118
78SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18348258
79VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.17916758
80CBP_20019798_ChIP-Seq_JUKART_Human1.17896803
81IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.17896803
82DNAJC2_21179169_ChIP-ChIP_NT2_Human1.17325443
83CDX2_19796622_ChIP-Seq_MESCs_Mouse1.14068460
84TP53_16413492_ChIP-PET_HCT116_Human1.13654127
85TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.13179932
86TCF4_23295773_ChIP-Seq_U87_Human1.12776518
87KDM2B_26808549_Chip-Seq_K562_Human1.11821424
88RNF2_27304074_Chip-Seq_NSC_Mouse1.11629037
89PCGF2_27294783_Chip-Seq_ESCs_Mouse1.10502486
90AHR_22903824_ChIP-Seq_MCF-7_Human1.10331976
91RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.09799722
92SMAD4_21741376_ChIP-Seq_EPCs_Human1.09500755
93RING1B_27294783_Chip-Seq_NPCs_Mouse1.09483306
94ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.09401427
95PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.09195850
96CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.08313559
97TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.07786252
98TOP2B_26459242_ChIP-Seq_MCF-7_Human1.07466717
99MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.07255835
100CTNNB1_20460455_ChIP-Seq_HCT116_Human1.07111616
101TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.06196012
102IGF1R_20145208_ChIP-Seq_DFB_Human1.05769011
103BMI1_23680149_ChIP-Seq_NPCS_Mouse1.05156905
104TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.04872359
105NR3C1_21868756_ChIP-Seq_MCF10A_Human1.04571834
106EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.04563451
107PCGF2_27294783_Chip-Seq_NPCs_Mouse1.02299364
108TCF4_22108803_ChIP-Seq_LS180_Human1.01681166
109SMAD_19615063_ChIP-ChIP_OVARY_Human1.01650398
110ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.01401407
111STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.00735630
112GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00692155
113NANOG_18555785_Chip-Seq_ESCs_Mouse1.00149048
114CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.99944052
115TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99909196
116SMAD3_21741376_ChIP-Seq_ESCs_Human0.99692689
117POU3F2_20337985_ChIP-ChIP_501MEL_Human0.99657455
118ESR1_20079471_ChIP-ChIP_T-47D_Human0.99154935
119TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.99104004
120SMAD4_21741376_ChIP-Seq_HESCs_Human0.98336326
121DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.97627347
122P53_22127205_ChIP-Seq_FIBROBLAST_Human0.97554856
123GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97053064
124ZFP281_18757296_ChIP-ChIP_E14_Mouse0.96921754
125RUNX2_22187159_ChIP-Seq_PCA_Human0.96011062
126CBX2_27304074_Chip-Seq_ESCs_Mouse0.95529536
127EP300_21415370_ChIP-Seq_HL-1_Mouse0.94932276
128MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.93952430
129BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.92654890
130SMAD3_21741376_ChIP-Seq_HESCs_Human0.91549895
131TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88697978
132OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.88677415
133RXR_22108803_ChIP-Seq_LS180_Human0.85556729
134MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.82713532

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.07704937
2MP0003136_yellow_coat_color4.12166445
3MP0003635_abnormal_synaptic_transmissio3.85186949
4MP0003880_abnormal_central_pattern3.60199667
5MP0004270_analgesia3.56728668
6MP0002063_abnormal_learning/memory/cond2.99386590
7MP0009745_abnormal_behavioral_response2.97109544
8MP0002064_seizures2.83586717
9MP0009046_muscle_twitch2.67736058
10MP0009780_abnormal_chondrocyte_physiolo2.60979218
11MP0002909_abnormal_adrenal_gland2.51239360
12MP0002572_abnormal_emotion/affect_behav2.48152681
13MP0002822_catalepsy2.46239159
14MP0001486_abnormal_startle_reflex2.42307276
15MP0005171_absent_coat_pigmentation2.38625665
16MP0002272_abnormal_nervous_system2.36163292
17MP0001968_abnormal_touch/_nociception2.34334324
18MP0005423_abnormal_somatic_nervous2.32078118
19MP0002734_abnormal_mechanical_nocicepti2.28558224
20MP0004147_increased_porphyrin_level2.15052858
21MP0005646_abnormal_pituitary_gland2.01853368
22MP0008569_lethality_at_weaning2.00879542
23MP0003646_muscle_fatigue1.94970238
24MP0003195_calcinosis1.91741658
25MP0000427_abnormal_hair_cycle1.88576500
26MP0002067_abnormal_sensory_capabilities1.79996558
27MP0001501_abnormal_sleep_pattern1.78270826
28MP0000778_abnormal_nervous_system1.76570182
29MP0003329_amyloid_beta_deposits1.75956452
30MP0003283_abnormal_digestive_organ1.71659232
31MP0002733_abnormal_thermal_nociception1.68690879
32MP0004811_abnormal_neuron_physiology1.68181645
33MP0001485_abnormal_pinna_reflex1.67912598
34MP0000955_abnormal_spinal_cord1.67825935
35MP0004924_abnormal_behavior1.65763399
36MP0005386_behavior/neurological_phenoty1.65763399
37MP0002557_abnormal_social/conspecific_i1.63739603
38MP0008877_abnormal_DNA_methylation1.62668236
39MP0004885_abnormal_endolymph1.61620213
40MP0002184_abnormal_innervation1.61195555
41MP0002735_abnormal_chemical_nociception1.59565107
42MP0000013_abnormal_adipose_tissue1.59506471
43MP0001970_abnormal_pain_threshold1.57219105
44MP0000383_abnormal_hair_follicle1.56912779
45MP0008961_abnormal_basal_metabolism1.55762114
46MP0004145_abnormal_muscle_electrophysio1.53117510
47MP0002736_abnormal_nociception_after1.51839307
48MP0004858_abnormal_nervous_system1.51821325
49MP0000569_abnormal_digit_pigmentation1.46356673
50MP0002882_abnormal_neuron_morphology1.45403787
51MP0001502_abnormal_circadian_rhythm1.44877470
52MP0005551_abnormal_eye_electrophysiolog1.43102100
53MP0003122_maternal_imprinting1.41408811
54MP0002837_dystrophic_cardiac_calcinosis1.40973570
55MP0001440_abnormal_grooming_behavior1.40686114
56MP0003633_abnormal_nervous_system1.40392486
57MP0003787_abnormal_imprinting1.35558534
58MP0004043_abnormal_pH_regulation1.34460794
59MP0001984_abnormal_olfaction1.33771896
60MP0002066_abnormal_motor_capabilities/c1.32311313
61MP0005645_abnormal_hypothalamus_physiol1.31915748
62MP0006072_abnormal_retinal_apoptosis1.31473832
63MP0002928_abnormal_bile_duct1.29211126
64MP0001299_abnormal_eye_distance/1.24365591
65MP0005174_abnormal_tail_pigmentation1.23617504
66MP0003634_abnormal_glial_cell1.21338403
67MP0003878_abnormal_ear_physiology1.19391552
68MP0005377_hearing/vestibular/ear_phenot1.19391552
69MP0003879_abnormal_hair_cell1.18252343
70MP0002160_abnormal_reproductive_system1.17613875
71MP0002229_neurodegeneration1.17242129
72MP0002168_other_aberrant_phenotype1.15904478
73MP0004233_abnormal_muscle_weight1.15463957
74MP0003690_abnormal_glial_cell1.14981905
75MP0001529_abnormal_vocalization1.14711486
76MP0002653_abnormal_ependyma_morphology1.14613202
77MP0004142_abnormal_muscle_tone1.14569513
78MP0000631_abnormal_neuroendocrine_gland1.12337453
79MP0004215_abnormal_myocardial_fiber1.11448018
80MP0004133_heterotaxia1.11294809
81MP0002152_abnormal_brain_morphology1.10650785
82MP0000751_myopathy1.10499548
83MP0003631_nervous_system_phenotype1.08965561
84MP0003183_abnormal_peptide_metabolism1.08781950
85MP0010386_abnormal_urinary_bladder1.08367247
86MP0000920_abnormal_myelination1.06086614
87MP0003172_abnormal_lysosome_physiology1.06074254
88MP0003137_abnormal_impulse_conducting1.05728964
89MP0002090_abnormal_vision1.04400421
90MP0008057_abnormal_DNA_replication0.99471990
91MP0003950_abnormal_plasma_membrane0.98349255
92MP0003045_fibrosis0.97486780
93MP0002938_white_spotting0.94579480
94MP0006276_abnormal_autonomic_nervous0.93299458
95MP0001348_abnormal_lacrimal_gland0.93226496
96MP0010234_abnormal_vibrissa_follicle0.92874934
97MP0005253_abnormal_eye_physiology0.91777117
98MP0002069_abnormal_eating/drinking_beha0.90198575
99MP0004085_abnormal_heartbeat0.89941793
100MP0002638_abnormal_pupillary_reflex0.87798975
101MP0005167_abnormal_blood-brain_barrier0.87450220
102MP0001664_abnormal_digestion0.87186443
103MP0004130_abnormal_muscle_cell0.86786468
104MP0001905_abnormal_dopamine_level0.85814874
105MP0001986_abnormal_taste_sensitivity0.85025127
106MP0005075_abnormal_melanosome_morpholog0.84281347
107MP0005647_abnormal_sex_gland0.84242032
108MP0003959_abnormal_lean_body0.83906020
109MP0003632_abnormal_nervous_system0.83814943
110MP0005195_abnormal_posterior_eye0.83003706
111MP0004381_abnormal_hair_follicle0.82672603
112MP0000026_abnormal_inner_ear0.81976859
113MP0003890_abnormal_embryonic-extraembry0.81976322
114MP0002095_abnormal_skin_pigmentation0.81404199
115MP0005670_abnormal_white_adipose0.81254499
116MP0000230_abnormal_systemic_arterial0.79775468
117MP0000372_irregular_coat_pigmentation0.79396188
118MP0010678_abnormal_skin_adnexa0.79027610
119MP0005389_reproductive_system_phenotype0.78890055
120MP0004484_altered_response_of0.78027077
121MP0005448_abnormal_energy_balance0.77590268
122MP0000003_abnormal_adipose_tissue0.77455771
123MP0002877_abnormal_melanocyte_morpholog0.77324633
124MP0002234_abnormal_pharynx_morphology0.76547792
125MP0002752_abnormal_somatic_nervous0.75766397
126MP0004742_abnormal_vestibular_system0.75630198
127MP0001944_abnormal_pancreas_morphology0.75228887
128MP0005187_abnormal_penis_morphology0.73988007
129MP0005535_abnormal_body_temperature0.73843678
130MP0005379_endocrine/exocrine_gland_phen0.70201420
131MP0000747_muscle_weakness0.69673314
132MP0001188_hyperpigmentation0.69137349
133MP0001177_atelectasis0.68915115
134MP0001963_abnormal_hearing_physiology0.67572597
135MP0002078_abnormal_glucose_homeostasis0.66492713
136MP0008874_decreased_physiological_sensi0.63269435
137MP0002693_abnormal_pancreas_physiology0.62823011
138MP0008872_abnormal_physiological_respon0.60288199
139MP0003075_altered_response_to0.60090194

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.59631082
2Myokymia (HP:0002411)5.22644547
3Visual hallucinations (HP:0002367)4.60205568
4Focal seizures (HP:0007359)4.49801094
5Epileptic encephalopathy (HP:0200134)3.99933487
6Pancreatic cysts (HP:0001737)3.85309298
7Action tremor (HP:0002345)3.82071435
8Clumsiness (HP:0002312)3.81401810
9Progressive cerebellar ataxia (HP:0002073)3.68255906
10True hermaphroditism (HP:0010459)3.59723008
11Pancreatic fibrosis (HP:0100732)3.59342581
12Papilledema (HP:0001085)3.45608080
13Protruding tongue (HP:0010808)3.41261140
14Attenuation of retinal blood vessels (HP:0007843)3.37870809
15Absence seizures (HP:0002121)3.32515510
16Supranuclear gaze palsy (HP:0000605)3.30468865
17Dysdiadochokinesis (HP:0002075)3.25041351
18Febrile seizures (HP:0002373)3.24784353
19Depression (HP:0000716)3.20808356
20Ankle clonus (HP:0011448)3.15650579
21Truncal ataxia (HP:0002078)3.13408100
22Atonic seizures (HP:0010819)3.06654803
23Generalized tonic-clonic seizures (HP:0002069)3.01874961
24Macroorchidism (HP:0000053)2.94388594
25Dialeptic seizures (HP:0011146)2.93819371
26Intention tremor (HP:0002080)2.93120936
27Poor eye contact (HP:0000817)2.92431827
28Broad-based gait (HP:0002136)2.91466511
29Chronic hepatic failure (HP:0100626)2.89835697
30Abnormality of the renal cortex (HP:0011035)2.88553144
31Dysmetria (HP:0001310)2.88547872
32Megalencephaly (HP:0001355)2.87281229
33Postural instability (HP:0002172)2.85380554
34Cystic liver disease (HP:0006706)2.82646613
35Proximal tubulopathy (HP:0000114)2.81097594
36Scanning speech (HP:0002168)2.80245718
37Abnormal social behavior (HP:0012433)2.76076906
38Impaired social interactions (HP:0000735)2.76076906
39Gaze-evoked nystagmus (HP:0000640)2.76061891
40Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.73661298
41Drooling (HP:0002307)2.72154831
42Excessive salivation (HP:0003781)2.72154831
43Anxiety (HP:0000739)2.71374041
44Neurofibrillary tangles (HP:0002185)2.70986208
45Congenital sensorineural hearing impairment (HP:0008527)2.69806543
46Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.63586673
47Hyperkalemia (HP:0002153)2.62457381
48Molar tooth sign on MRI (HP:0002419)2.61270555
49Abnormality of midbrain morphology (HP:0002418)2.61270555
50Urinary bladder sphincter dysfunction (HP:0002839)2.60461246
51Impaired smooth pursuit (HP:0007772)2.59576011
52Impaired vibration sensation in the lower limbs (HP:0002166)2.59289815
53Epileptiform EEG discharges (HP:0011182)2.55716690
54EEG with generalized epileptiform discharges (HP:0011198)2.55526586
55Pendular nystagmus (HP:0012043)2.54837619
56Polydipsia (HP:0001959)2.54508075
57Abnormal drinking behavior (HP:0030082)2.54508075
58Type II lissencephaly (HP:0007260)2.54105139
59Fair hair (HP:0002286)2.50122722
60Genetic anticipation (HP:0003743)2.50042922
61Cerebral inclusion bodies (HP:0100314)2.49795549
62Decreased circulating renin level (HP:0003351)2.47677894
63Hemiplegia (HP:0002301)2.47161680
64Chorioretinal atrophy (HP:0000533)2.47003918
65Hypsarrhythmia (HP:0002521)2.46141130
66Spastic gait (HP:0002064)2.45390111
67Hyperventilation (HP:0002883)2.44618616
68Keratoconus (HP:0000563)2.44550821
69Increased corneal curvature (HP:0100692)2.44550821
70Central scotoma (HP:0000603)2.38734735
71Agitation (HP:0000713)2.37146668
72Ankyloglossia (HP:0010296)2.35723032
73Hemiparesis (HP:0001269)2.35322187
74Furrowed tongue (HP:0000221)2.35108573
75Decreased central vision (HP:0007663)2.35038913
76Increased neuronal autofluorescent lipopigment (HP:0002074)2.34265935
77Sclerocornea (HP:0000647)2.33009777
78Nephronophthisis (HP:0000090)2.32765871
79Abnormal eating behavior (HP:0100738)2.31896357
80Oligodactyly (hands) (HP:0001180)2.31405070
81Urinary urgency (HP:0000012)2.28886511
82Severe visual impairment (HP:0001141)2.28273121
83Torticollis (HP:0000473)2.28134904
84Hyperalaninemia (HP:0003348)2.27136225
85Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.27136225
86Abnormality of alanine metabolism (HP:0010916)2.27136225
87Pheochromocytoma (HP:0002666)2.27130866
88Abnormality of the renal medulla (HP:0100957)2.25364730
89Generalized aminoaciduria (HP:0002909)2.22952242
90Bradykinesia (HP:0002067)2.22116285
91Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.21750818
92Abnormality of ocular smooth pursuit (HP:0000617)2.20578564
93Birth length less than 3rd percentile (HP:0003561)2.20341996
94Bony spicule pigmentary retinopathy (HP:0007737)2.20126922
95Mutism (HP:0002300)2.19069736
96Hypoplastic ischia (HP:0003175)2.17584098
97Inability to walk (HP:0002540)2.17355261
98Abnormality of the ischium (HP:0003174)2.16383651
99Stereotypic behavior (HP:0000733)2.16233731
100Dysmetric saccades (HP:0000641)2.15543607
101Insomnia (HP:0100785)2.15458502
102Lower limb muscle weakness (HP:0007340)2.15203215
103Congenital hepatic fibrosis (HP:0002612)2.12981206
104Neoplasm of the heart (HP:0100544)2.10375649
105Aplasia/Hypoplasia of the tongue (HP:0010295)2.09558897
106Abnormality of macular pigmentation (HP:0008002)2.09152713
107Termporal pattern (HP:0011008)2.08635517
108Insidious onset (HP:0003587)2.08635517
109Prolonged QT interval (HP:0001657)2.07525669
110Tubular atrophy (HP:0000092)2.06810840
111Acute lymphatic leukemia (HP:0006721)2.06407837
112Focal dystonia (HP:0004373)2.06268326
113Aplasia/Hypoplasia of the tibia (HP:0005772)2.05817590
114Large for gestational age (HP:0001520)2.05791815
115Postaxial foot polydactyly (HP:0001830)2.05076488
116Abnormal EKG (HP:0003115)2.03140590
117Blue irides (HP:0000635)2.01958277
118Clonus (HP:0002169)2.01830967
119Renal cortical cysts (HP:0000803)2.00777888
120Widely spaced teeth (HP:0000687)1.99248076
121Pointed chin (HP:0000307)1.98922133
122Abolished electroretinogram (ERG) (HP:0000550)1.98796143
123Progressive inability to walk (HP:0002505)1.96352519
124Amblyopia (HP:0000646)1.95791297
125Menstrual irregularities (HP:0000858)1.94727151
126Abnormality of the lower motor neuron (HP:0002366)1.93977274
127Resting tremor (HP:0002322)1.93038706
128Abnormality of binocular vision (HP:0011514)1.90289243
129Diplopia (HP:0000651)1.90289243
130Retinal dysplasia (HP:0007973)1.89565001
131Impaired vibratory sensation (HP:0002495)1.88365048
132Abnormality of the corticospinal tract (HP:0002492)1.88187574
133Aplasia involving bones of the upper limbs (HP:0009823)1.88013845
134Aplasia of the phalanges of the hand (HP:0009802)1.88013845
135Aplasia involving bones of the extremities (HP:0009825)1.88013845
136Bundle branch block (HP:0011710)1.87857640
137Gait ataxia (HP:0002066)1.84094333
138Craniofacial dystonia (HP:0012179)1.83944901
139Anencephaly (HP:0002323)1.82911972
140Occipital encephalocele (HP:0002085)1.82131058
141Hyperinsulinemic hypoglycemia (HP:0000825)1.82042863
142Depressed nasal tip (HP:0000437)1.80820706
143Aplasia/Hypoplasia of the fovea (HP:0008060)1.80357204
144Hypoplasia of the fovea (HP:0007750)1.80357204
145Status epilepticus (HP:0002133)1.80109185
146Neuroendocrine neoplasm (HP:0100634)1.79427466
147Open mouth (HP:0000194)1.79313264
148Patellar aplasia (HP:0006443)1.79145620
149Short foot (HP:0001773)1.78589644
150Absent speech (HP:0001344)1.77774037
151Abnormality of oral frenula (HP:0000190)1.77059301
152Hypoplasia of the iris (HP:0007676)1.76978373
153Lower limb amyotrophy (HP:0007210)1.76779154
154Generalized hypopigmentation of hair (HP:0011358)1.76357862
155Aqueductal stenosis (HP:0002410)1.75571221
156Small hand (HP:0200055)1.75201442
157Ventricular fibrillation (HP:0001663)1.74178064
158Medial flaring of the eyebrow (HP:0010747)1.73731988
159Gait imbalance (HP:0002141)1.73299701
160Congenital stationary night blindness (HP:0007642)1.72795143
161Concave nail (HP:0001598)1.69992676
162Postural tremor (HP:0002174)1.69932502
163Abnormality of potassium homeostasis (HP:0011042)1.67906909
164Aplasia/Hypoplasia of the patella (HP:0006498)1.67500884
165Obsessive-compulsive behavior (HP:0000722)1.66990062
166Spinal canal stenosis (HP:0003416)1.66285334
167Generalized myoclonic seizures (HP:0002123)1.65983328
168Intellectual disability, progressive (HP:0006887)1.65964017
169Hypoventilation (HP:0002791)1.65879742
170Palpebral edema (HP:0100540)1.63150597

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.13298912
2BMPR1B3.24077665
3MAP3K93.23682665
4EPHA43.11921949
5NTRK13.02583614
6MARK13.00917295
7NTRK22.93961812
8LATS12.74172731
9PRKD32.63941092
10ACVR1B2.61045405
11MAP3K42.52014119
12KSR12.37004190
13MUSK2.33784128
14ADRBK22.30217546
15MINK12.29952759
16PAK62.26583182
17DAPK22.10633301
18TNIK2.05446554
19MAP2K71.85075495
20KSR21.82488347
21SIK31.67481523
22CAMKK11.65389625
23CDK51.52167503
24STK38L1.50607200
25GRK11.48078383
26MAP3K21.41939581
27PHKG21.38189771
28PHKG11.38189771
29FGFR21.36863382
30CAMKK21.31437595
31MAP2K41.31369963
32PTK2B1.31238688
33CDK121.28028396
34UHMK11.26841801
35INSRR1.25070047
36PRKCH1.24931237
37PRPF4B1.18912888
38ADRBK11.16197649
39STK381.13655910
40AKT31.12222566
41TAOK11.11464067
42CAMK1G1.08867689
43MAPK131.08688815
44STK391.06891126
45WNK41.04464906
46TYRO31.03932234
47PIK3CA1.03837911
48SCYL21.03217308
49SGK2231.03019221
50SGK4941.03019221
51MARK21.02552397
52PAK31.01239648
53CDK190.99388778
54FES0.98213737
55SIK10.97986745
56RET0.97928823
57SIK20.95255955
58LMTK20.94968488
59TAOK30.93812487
60CDC42BPA0.92285346
61STK110.91818743
62ZAK0.90614057
63MAP2K10.89477315
64MKNK20.89441675
65MAPKAPK30.88822062
66NUAK10.86732897
67CASK0.86441869
68TGFBR10.86301361
69BCR0.86104880
70PRKCG0.85917116
71DAPK10.85827280
72CAMK10.85741618
73NEK90.85494457
74CSNK1A1L0.84536457
75CDK180.84326806
76MAP3K130.84067618
77CAMK2A0.82803237
78SGK20.82441887
79SGK30.82072701
80WEE10.81900972
81MAP3K70.78893180
82HIPK20.78306117
83GRK50.77265971
84FRK0.76489834
85NLK0.76096029
86GRK70.75189435
87CDK150.75043947
88MAP4K20.74009762
89SGK10.73608299
90PDGFRA0.73330428
91MELK0.72930230
92DMPK0.72822705
93MAP3K10.72612802
94PDGFRB0.71635936
95STK30.71277299
96CHEK20.70912426
97CDK140.70603421
98TRPM70.70444844
99CAMK2B0.69039333
100MAP3K120.68812258
101WNK10.67567914
102TLK10.67238779
103PNCK0.66190669
104CSNK1G20.65260000
105RIPK10.63880907
106NEK60.63809716
107MAPKAPK50.63685026
108OXSR10.62810674
109CDK11A0.62220856
110TAF10.61937395
111WNK30.60278130
112ALK0.59712506
113TNK20.59116616
114IRAK10.58771525
115RIPK40.58468513
116PRKD20.58357084
117PDK10.58299588
118PINK10.57804730
119RPS6KA30.57733423
120FYN0.55968729
121MAP2K60.54413872
122ICK0.53754988
123MAPK150.53622357
124CAMK2D0.53063493
125DYRK1A0.52994257
126PDPK10.52438304
127CAMK1D0.51728876
128RAF10.50276181
129MAPK100.50040536
130PRKCZ0.49517746
131PLK20.48990895
132PRKCE0.48155269
133LATS20.47162994
134TRIB30.46442999
135FER0.45919108
136ERBB20.45418756
137PRKAA20.44466382
138PKN10.44018876
139CAMK40.43983527
140CSNK1D0.43559281
141MAP2K20.43277099
142PRKAA10.42908160
143CSNK1G10.42867877
144RPS6KA60.38212212
145PRKACB0.35567137
146OBSCN0.35184737

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.02348219
2GABAergic synapse_Homo sapiens_hsa047272.67771900
3Synaptic vesicle cycle_Homo sapiens_hsa047212.62686094
4Circadian entrainment_Homo sapiens_hsa047132.49886338
5Insulin secretion_Homo sapiens_hsa049112.41200461
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.34013915
7Morphine addiction_Homo sapiens_hsa050322.33484483
8Glutamatergic synapse_Homo sapiens_hsa047242.32083003
9Long-term potentiation_Homo sapiens_hsa047202.31348147
10Olfactory transduction_Homo sapiens_hsa047402.22291883
11Amphetamine addiction_Homo sapiens_hsa050312.11266115
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.10459046
13Salivary secretion_Homo sapiens_hsa049701.98229970
14Dopaminergic synapse_Homo sapiens_hsa047281.92629325
15Cholinergic synapse_Homo sapiens_hsa047251.82538611
16Aldosterone synthesis and secretion_Homo sapiens_hsa049251.82255709
17Gastric acid secretion_Homo sapiens_hsa049711.73706840
18Selenocompound metabolism_Homo sapiens_hsa004501.72024379
19ABC transporters_Homo sapiens_hsa020101.70651749
20Cocaine addiction_Homo sapiens_hsa050301.70407619
21Nitrogen metabolism_Homo sapiens_hsa009101.69644621
22Type II diabetes mellitus_Homo sapiens_hsa049301.67582861
23Histidine metabolism_Homo sapiens_hsa003401.66713166
24Renin secretion_Homo sapiens_hsa049241.64885727
25Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.64262809
26Taste transduction_Homo sapiens_hsa047421.50688998
27Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.50209551
28Oxytocin signaling pathway_Homo sapiens_hsa049211.48328640
29alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.46684183
30Serotonergic synapse_Homo sapiens_hsa047261.43595015
31Long-term depression_Homo sapiens_hsa047301.43221126
32Linoleic acid metabolism_Homo sapiens_hsa005911.42243144
33Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.42195046
34Calcium signaling pathway_Homo sapiens_hsa040201.40219879
35Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.37215368
36cAMP signaling pathway_Homo sapiens_hsa040241.33046244
37Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.31365154
38Renin-angiotensin system_Homo sapiens_hsa046141.27755728
39Gap junction_Homo sapiens_hsa045401.26878068
40Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.25860070
41GnRH signaling pathway_Homo sapiens_hsa049121.25295159
42Estrogen signaling pathway_Homo sapiens_hsa049151.22922780
43Glioma_Homo sapiens_hsa052141.21661082
44Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.16808393
45Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.15286121
46ErbB signaling pathway_Homo sapiens_hsa040121.13067318
47cGMP-PKG signaling pathway_Homo sapiens_hsa040221.12019923
48Phosphatidylinositol signaling system_Homo sapiens_hsa040701.11573212
49Axon guidance_Homo sapiens_hsa043601.10795605
50Phototransduction_Homo sapiens_hsa047441.06474763
51Pancreatic secretion_Homo sapiens_hsa049721.04767478
52Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.04740803
53Dorso-ventral axis formation_Homo sapiens_hsa043201.03733877
54Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.02488023
55Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.01676846
56Tryptophan metabolism_Homo sapiens_hsa003801.01410831
57Melanogenesis_Homo sapiens_hsa049161.01392704
58Carbohydrate digestion and absorption_Homo sapiens_hsa049731.00994112
59Dilated cardiomyopathy_Homo sapiens_hsa054140.99912913
60Ether lipid metabolism_Homo sapiens_hsa005650.97394633
61Steroid hormone biosynthesis_Homo sapiens_hsa001400.96655159
62Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.95567732
63Lysine degradation_Homo sapiens_hsa003100.94873111
64One carbon pool by folate_Homo sapiens_hsa006700.94238959
65Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.93694324
66Thyroid hormone synthesis_Homo sapiens_hsa049180.93120319
67Vascular smooth muscle contraction_Homo sapiens_hsa042700.91238842
68Phospholipase D signaling pathway_Homo sapiens_hsa040720.88609143
69Maturity onset diabetes of the young_Homo sapiens_hsa049500.86375895
70Circadian rhythm_Homo sapiens_hsa047100.85940649
71Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.79620976
72Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.78965201
73Vibrio cholerae infection_Homo sapiens_hsa051100.78488885
74Glucagon signaling pathway_Homo sapiens_hsa049220.76753245
75Thyroid hormone signaling pathway_Homo sapiens_hsa049190.76654409
76Collecting duct acid secretion_Homo sapiens_hsa049660.75618355
77Choline metabolism in cancer_Homo sapiens_hsa052310.75312915
78mTOR signaling pathway_Homo sapiens_hsa041500.74875241
79Melanoma_Homo sapiens_hsa052180.74381547
80Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.73887248
81Glycerolipid metabolism_Homo sapiens_hsa005610.73793036
82Primary bile acid biosynthesis_Homo sapiens_hsa001200.71913323
83Neurotrophin signaling pathway_Homo sapiens_hsa047220.71614150
84Pentose and glucuronate interconversions_Homo sapiens_hsa000400.69901889
85Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.67188597
86Endometrial cancer_Homo sapiens_hsa052130.66756857
87Chemical carcinogenesis_Homo sapiens_hsa052040.66743007
88Longevity regulating pathway - mammal_Homo sapiens_hsa042110.66623326
89MAPK signaling pathway_Homo sapiens_hsa040100.66298557
90Insulin signaling pathway_Homo sapiens_hsa049100.66143226
91Non-small cell lung cancer_Homo sapiens_hsa052230.63985933
92Fanconi anemia pathway_Homo sapiens_hsa034600.63980276
93Renal cell carcinoma_Homo sapiens_hsa052110.62262351
94Retinol metabolism_Homo sapiens_hsa008300.62261313
95beta-Alanine metabolism_Homo sapiens_hsa004100.61680864
96Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.60494415
97Sphingolipid metabolism_Homo sapiens_hsa006000.59996310
98Cardiac muscle contraction_Homo sapiens_hsa042600.59209926
99Homologous recombination_Homo sapiens_hsa034400.59014131
100Inositol phosphate metabolism_Homo sapiens_hsa005620.58697829
101Ras signaling pathway_Homo sapiens_hsa040140.58369958
102Oocyte meiosis_Homo sapiens_hsa041140.58352992
103Bile secretion_Homo sapiens_hsa049760.57222039
104Hippo signaling pathway_Homo sapiens_hsa043900.56952791
105Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.56535708
106Type I diabetes mellitus_Homo sapiens_hsa049400.53341819
107Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.52727704
108Rap1 signaling pathway_Homo sapiens_hsa040150.51851148
109VEGF signaling pathway_Homo sapiens_hsa043700.51532011
110Alcoholism_Homo sapiens_hsa050340.51123418
111Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.49108322
112Wnt signaling pathway_Homo sapiens_hsa043100.49037041
113Caffeine metabolism_Homo sapiens_hsa002320.48212375
114Sulfur relay system_Homo sapiens_hsa041220.48192869
115Glycerophospholipid metabolism_Homo sapiens_hsa005640.47543850
116Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.46689082
117Arachidonic acid metabolism_Homo sapiens_hsa005900.46281178
118Sphingolipid signaling pathway_Homo sapiens_hsa040710.46107349
119Hedgehog signaling pathway_Homo sapiens_hsa043400.45910858
120Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.45613171
121Basal cell carcinoma_Homo sapiens_hsa052170.45530795
122Butanoate metabolism_Homo sapiens_hsa006500.45273486
123Platelet activation_Homo sapiens_hsa046110.45185978
124Endocytosis_Homo sapiens_hsa041440.44282711
125ECM-receptor interaction_Homo sapiens_hsa045120.43852018
126FoxO signaling pathway_Homo sapiens_hsa040680.42775394
127Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.42243065
128Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.42122485
129Prolactin signaling pathway_Homo sapiens_hsa049170.38641962
130Prion diseases_Homo sapiens_hsa050200.38192185
131Insulin resistance_Homo sapiens_hsa049310.37714944
132AMPK signaling pathway_Homo sapiens_hsa041520.37128020
133Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.33672896
134N-Glycan biosynthesis_Homo sapiens_hsa005100.33421612
135Ovarian steroidogenesis_Homo sapiens_hsa049130.33333244
136Chemokine signaling pathway_Homo sapiens_hsa040620.33109246
137Colorectal cancer_Homo sapiens_hsa052100.32953955
138Fatty acid biosynthesis_Homo sapiens_hsa000610.32923313
139Central carbon metabolism in cancer_Homo sapiens_hsa052300.31300041

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