FAM124A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1vocalization behavior (GO:0071625)5.21979487
2neuron cell-cell adhesion (GO:0007158)5.02732948
3pyrimidine nucleobase catabolic process (GO:0006208)4.95043316
4behavioral response to nicotine (GO:0035095)4.94998992
5regulation of posttranscriptional gene silencing (GO:0060147)4.92297679
6regulation of gene silencing by miRNA (GO:0060964)4.92297679
7regulation of gene silencing by RNA (GO:0060966)4.92297679
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.84505226
9regulation of short-term neuronal synaptic plasticity (GO:0048172)4.55292753
10positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.42873718
11nucleobase catabolic process (GO:0046113)4.39653356
12regulation of glutamate receptor signaling pathway (GO:1900449)4.39499166
13layer formation in cerebral cortex (GO:0021819)4.32575614
14protein localization to synapse (GO:0035418)4.30933773
15synaptic vesicle exocytosis (GO:0016079)4.28292258
16proline transport (GO:0015824)4.20060613
17DNA deamination (GO:0045006)4.16723929
18neurotransmitter-gated ion channel clustering (GO:0072578)4.12430584
19locomotory exploration behavior (GO:0035641)4.11177948
20glutamate secretion (GO:0014047)4.00767960
21sulfation (GO:0051923)3.97149646
22water-soluble vitamin biosynthetic process (GO:0042364)3.96715633
23synaptic vesicle maturation (GO:0016188)3.95205559
24neuron recognition (GO:0008038)3.94312078
25gamma-aminobutyric acid transport (GO:0015812)3.88579757
26regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.87963476
27postsynaptic membrane organization (GO:0001941)3.83739638
28positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.79847828
29regulation of synapse structural plasticity (GO:0051823)3.75108183
30exploration behavior (GO:0035640)3.75053636
31ionotropic glutamate receptor signaling pathway (GO:0035235)3.74408246
32dendritic spine morphogenesis (GO:0060997)3.66768662
33glutamate receptor signaling pathway (GO:0007215)3.59449910
34regulation of synaptic vesicle exocytosis (GO:2000300)3.55417450
35regulation of mesoderm development (GO:2000380)3.54151342
36presynaptic membrane assembly (GO:0097105)3.53193333
37neurotransmitter secretion (GO:0007269)3.50571739
38axonal fasciculation (GO:0007413)3.48830403
39mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.45812583
40mitochondrial respiratory chain complex I assembly (GO:0032981)3.45812583
41NADH dehydrogenase complex assembly (GO:0010257)3.45812583
42dendrite morphogenesis (GO:0048813)3.40063156
43establishment of protein localization to mitochondrial membrane (GO:0090151)3.39601563
44protein complex biogenesis (GO:0070271)3.39181196
45synaptic vesicle docking involved in exocytosis (GO:0016081)3.36488988
46positive regulation of synapse maturation (GO:0090129)3.32506252
47somite development (GO:0061053)3.31453042
48synaptic transmission, glutamatergic (GO:0035249)3.29236747
49regulation of long-term neuronal synaptic plasticity (GO:0048169)3.26751232
50protein polyglutamylation (GO:0018095)3.26335513
51cell migration in hindbrain (GO:0021535)3.25851488
52mitochondrial respiratory chain complex assembly (GO:0033108)3.22991734
53kidney morphogenesis (GO:0060993)3.22153428
54neuron-neuron synaptic transmission (GO:0007270)3.21739796
55negative regulation of synaptic transmission, GABAergic (GO:0032229)3.21681908
56regulation of neuronal synaptic plasticity (GO:0048168)3.19391375
57alanine transport (GO:0032328)3.14694082
58regulation of synaptic vesicle transport (GO:1902803)3.10348621
59negative regulation of telomere maintenance (GO:0032205)3.09902957
60regulation of excitatory postsynaptic membrane potential (GO:0060079)3.07855820
61transmission of nerve impulse (GO:0019226)3.06703594
62auditory behavior (GO:0031223)3.04547531
63ovulation cycle (GO:0042698)3.04517791
64presynaptic membrane organization (GO:0097090)3.03090926
65regulation of synaptic transmission, glutamatergic (GO:0051966)3.00782345
66positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.00449536
67long-term memory (GO:0007616)2.98381904
68regulation of dendritic spine morphogenesis (GO:0061001)2.98361947
69cell proliferation in forebrain (GO:0021846)2.96511077
70cellular response to ATP (GO:0071318)2.96449572
71central nervous system projection neuron axonogenesis (GO:0021952)2.96240606
72regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.95922551
73G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.95293471
74regulation of postsynaptic membrane potential (GO:0060078)2.94374475
75cerebellar granule cell differentiation (GO:0021707)2.94179078
76negative regulation of transcription regulatory region DNA binding (GO:2000678)2.94171294
77response to histamine (GO:0034776)2.93162427
78mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.92210229
79response to auditory stimulus (GO:0010996)2.91913836
80energy coupled proton transport, down electrochemical gradient (GO:0015985)2.91370818
81ATP synthesis coupled proton transport (GO:0015986)2.91370818
82synapse assembly (GO:0007416)2.91232997
83negative regulation of DNA-dependent DNA replication (GO:2000104)2.90793228
84nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.90425023
85neurotransmitter transport (GO:0006836)2.88997349
86negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.88881403
87negative regulation of translation, ncRNA-mediated (GO:0040033)2.88881403
88regulation of translation, ncRNA-mediated (GO:0045974)2.88881403
89regulation of collateral sprouting (GO:0048670)2.86281179
90exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.85485106
91gamma-aminobutyric acid signaling pathway (GO:0007214)2.85439525
92chaperone-mediated protein transport (GO:0072321)2.85269583
93response to pheromone (GO:0019236)2.84726066
94axon extension (GO:0048675)2.84189198
95RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.83056798
96tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.83056798
97positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.81376911
98membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.80159979
99regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.80118913
100protein neddylation (GO:0045116)2.80009369
101RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.79060239
102positive regulation of synapse assembly (GO:0051965)2.78221871
103regulation of dendritic spine development (GO:0060998)2.77566011
104kynurenine metabolic process (GO:0070189)2.77543119
105regulation of synapse maturation (GO:0090128)2.74484177
106positive regulation of dendritic spine development (GO:0060999)2.74009632
107L-fucose catabolic process (GO:0042355)2.73201175
108fucose catabolic process (GO:0019317)2.73201175
109L-fucose metabolic process (GO:0042354)2.73201175
110positive regulation of membrane potential (GO:0045838)2.73190291
111regulation of DNA endoreduplication (GO:0032875)2.73148796
112protein-cofactor linkage (GO:0018065)2.73089204
113lateral sprouting from an epithelium (GO:0060601)2.72616043
114detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.72262732
115negative regulation of telomerase activity (GO:0051974)2.72150536
116G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.70003962
117long-term synaptic potentiation (GO:0060291)2.69905398
118cell communication by electrical coupling (GO:0010644)2.68812624
119regulation of synaptic plasticity (GO:0048167)2.68724450
120regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.68069779
121behavioral fear response (GO:0001662)2.67443451
122behavioral defense response (GO:0002209)2.67443451
123otic vesicle formation (GO:0030916)2.66559755
124startle response (GO:0001964)2.66281562
125regulation of neurotransmitter levels (GO:0001505)2.65946845
126retinal cone cell development (GO:0046549)2.65795130
127prepulse inhibition (GO:0060134)2.65464082
128negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.64785046
129regulation of neurotransmitter secretion (GO:0046928)2.64763312
130lung-associated mesenchyme development (GO:0060484)2.63295075
131mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.63009477
132synapse organization (GO:0050808)2.60820966
133regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.59132617
134regulation of mitotic spindle checkpoint (GO:1903504)2.59132617
135neuronal action potential propagation (GO:0019227)2.58992447
136detection of light stimulus involved in sensory perception (GO:0050962)2.58680363
137detection of light stimulus involved in visual perception (GO:0050908)2.58680363
138regulation of glomerulus development (GO:0090192)2.58181029
139synaptic vesicle endocytosis (GO:0048488)2.57896476
140replication fork processing (GO:0031297)2.57199178
141membrane depolarization (GO:0051899)2.56723503
142intraspecies interaction between organisms (GO:0051703)2.56300767
143social behavior (GO:0035176)2.56300767
144learning (GO:0007612)2.55591842
145regulation of synapse assembly (GO:0051963)2.55161228
146regulation of rhodopsin mediated signaling pathway (GO:0022400)2.54835918
147positive regulation of potassium ion transmembrane transport (GO:1901381)2.54624457
148axon ensheathment in central nervous system (GO:0032291)2.54044263
149central nervous system myelination (GO:0022010)2.54044263
150regulation of neurotransmitter uptake (GO:0051580)2.53544626
151regulation of vesicle fusion (GO:0031338)2.53321640
152regulation of cAMP-dependent protein kinase activity (GO:2000479)2.52472393
153transcription elongation from RNA polymerase III promoter (GO:0006385)2.52283317
154termination of RNA polymerase III transcription (GO:0006386)2.52283317
155fear response (GO:0042596)2.51311800
156mating behavior (GO:0007617)2.51100906
157activation of protein kinase A activity (GO:0034199)2.50778444
158regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.50594754
159adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.50378324
160regulation of synapse organization (GO:0050807)2.50356658
161negative regulation of astrocyte differentiation (GO:0048712)2.49563456
162innervation (GO:0060384)2.49249738
163tryptophan catabolic process (GO:0006569)2.49140129
164indole-containing compound catabolic process (GO:0042436)2.49140129
165indolalkylamine catabolic process (GO:0046218)2.49140129
166pituitary gland development (GO:0021983)2.49007618
167negative regulation of dendrite development (GO:2000171)2.48885996
168positive regulation of synaptic transmission, GABAergic (GO:0032230)2.48350229
169cerebral cortex neuron differentiation (GO:0021895)2.47800745
170epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.47735554
171positive regulation of dendritic spine morphogenesis (GO:0061003)2.47025626
172outer ear morphogenesis (GO:0042473)2.46834965
173indolalkylamine metabolic process (GO:0006586)2.46514548
174DNA double-strand break processing (GO:0000729)2.46337109
175ncRNA catabolic process (GO:0034661)2.45991116
176regulation of action potential (GO:0098900)2.44870308
177photoreceptor cell development (GO:0042461)2.44828127
178primary amino compound metabolic process (GO:1901160)2.43759446
179respiratory chain complex IV assembly (GO:0008535)2.42465983
180serotonin metabolic process (GO:0042428)2.41507235
181endoderm formation (GO:0001706)2.41483920
182parturition (GO:0007567)2.40740646
183neuronal action potential (GO:0019228)2.40315286
184negative regulation of mast cell activation (GO:0033004)2.40140077
185negative regulation of gene silencing (GO:0060969)2.40133779
186regulation of nuclear cell cycle DNA replication (GO:0033262)2.39782387
187platelet dense granule organization (GO:0060155)2.38438199
188chromatin remodeling at centromere (GO:0031055)2.37809880
189rhodopsin mediated signaling pathway (GO:0016056)2.37779917
190membrane depolarization during action potential (GO:0086010)2.37703766
191piRNA metabolic process (GO:0034587)2.36307165
192recombinational repair (GO:0000725)2.34999119

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.22432731
2GBX2_23144817_ChIP-Seq_PC3_Human3.33819312
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.93633342
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.80683779
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.79833221
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.74527074
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.55284108
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.55284108
9EZH2_27304074_Chip-Seq_ESCs_Mouse2.52725571
10SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.51259160
11SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.48741104
12GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.42489649
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.41808864
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.38743464
15EED_16625203_ChIP-ChIP_MESCs_Mouse2.34504975
16MTF2_20144788_ChIP-Seq_MESCs_Mouse2.29375669
17AR_21572438_ChIP-Seq_LNCaP_Human2.29028984
18MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.27423554
19SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.23804680
20REST_21632747_ChIP-Seq_MESCs_Mouse2.12782390
21EZH2_27294783_Chip-Seq_ESCs_Mouse2.12288713
22FLI1_27457419_Chip-Seq_LIVER_Mouse2.07626515
23HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.06315636
24EWS_26573619_Chip-Seq_HEK293_Human2.05425975
25SUZ12_27294783_Chip-Seq_ESCs_Mouse2.03334781
26RNF2_27304074_Chip-Seq_ESCs_Mouse2.00224535
27DROSHA_22980978_ChIP-Seq_HELA_Human1.98323274
28NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.97522681
29CTBP2_25329375_ChIP-Seq_LNCAP_Human1.96485553
30TAF15_26573619_Chip-Seq_HEK293_Human1.96482205
31ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.92680259
32IRF1_19129219_ChIP-ChIP_H3396_Human1.85944456
33POU5F1_16153702_ChIP-ChIP_HESCs_Human1.83146945
34ZFP57_27257070_Chip-Seq_ESCs_Mouse1.75737289
35GABP_17652178_ChIP-ChIP_JURKAT_Human1.75694369
36CTBP1_25329375_ChIP-Seq_LNCAP_Human1.70515517
37EST1_17652178_ChIP-ChIP_JURKAT_Human1.70446676
38KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.69880903
39MYC_18940864_ChIP-ChIP_HL60_Human1.69326888
40PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.65094442
41CBX2_27304074_Chip-Seq_ESCs_Mouse1.63752835
42REST_18959480_ChIP-ChIP_MESCs_Mouse1.61395192
43MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.59473621
44PCGF2_27294783_Chip-Seq_ESCs_Mouse1.59424764
45SMAD4_21799915_ChIP-Seq_A2780_Human1.57412032
46CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.57168223
47IKZF1_21737484_ChIP-ChIP_HCT116_Human1.53072304
48FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.50947018
49RARB_27405468_Chip-Seq_BRAIN_Mouse1.50468506
50PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.48689971
51GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.47054197
52SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.45611819
53RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.45466915
54EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.45411177
55P300_19829295_ChIP-Seq_ESCs_Human1.44917579
56E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.43405233
57PIAS1_25552417_ChIP-Seq_VCAP_Human1.41922054
58SALL1_21062744_ChIP-ChIP_HESCs_Human1.41300168
59NOTCH1_21737748_ChIP-Seq_TLL_Human1.40259514
60CDX2_19796622_ChIP-Seq_MESCs_Mouse1.38640132
61* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.37853665
62BMI1_23680149_ChIP-Seq_NPCS_Mouse1.37587990
63SMAD3_21741376_ChIP-Seq_EPCs_Human1.32229017
64SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29651796
65BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.28925155
66RING1B_27294783_Chip-Seq_ESCs_Mouse1.28018469
67MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.27823006
68AR_25329375_ChIP-Seq_VCAP_Human1.27242726
69TOP2B_26459242_ChIP-Seq_MCF-7_Human1.27075744
70SOX2_21211035_ChIP-Seq_LN229_Gbm1.26929864
71SOX2_16153702_ChIP-ChIP_HESCs_Human1.25783082
72TP53_22573176_ChIP-Seq_HFKS_Human1.24862776
73CBP_20019798_ChIP-Seq_JUKART_Human1.24331459
74IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.24331459
75EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.23357986
76OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22509041
77SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21458067
78SUZ12_27294783_Chip-Seq_NPCs_Mouse1.20644601
79ZNF217_24962896_ChIP-Seq_MCF-7_Human1.20404773
80RNF2_27304074_Chip-Seq_NSC_Mouse1.20251443
81RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.20100615
82SMAD_19615063_ChIP-ChIP_OVARY_Human1.19767012
83PCGF2_27294783_Chip-Seq_NPCs_Mouse1.19479319
84NANOG_19829295_ChIP-Seq_ESCs_Human1.18847807
85SOX2_19829295_ChIP-Seq_ESCs_Human1.18847807
86MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.18753512
87AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.18226308
88NR3C1_23031785_ChIP-Seq_PC12_Mouse1.17694093
89ZNF274_21170338_ChIP-Seq_K562_Hela1.17503315
90* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.17259919
91NFE2_27457419_Chip-Seq_LIVER_Mouse1.16655484
92UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.15827557
93ERG_21242973_ChIP-ChIP_JURKAT_Human1.15534963
94RING1B_27294783_Chip-Seq_NPCs_Mouse1.13409467
95AR_19668381_ChIP-Seq_PC3_Human1.13300282
96ARNT_22903824_ChIP-Seq_MCF-7_Human1.13010654
97STAT3_23295773_ChIP-Seq_U87_Human1.12661073
98TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.11099203
99TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.11006570
100FOXA1_27270436_Chip-Seq_PROSTATE_Human1.10519065
101FOXA1_25329375_ChIP-Seq_VCAP_Human1.10519065
102AHR_22903824_ChIP-Seq_MCF-7_Human1.10467580
103EZH2_27294783_Chip-Seq_NPCs_Mouse1.10120783
104ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.09940817
105KLF5_20875108_ChIP-Seq_MESCs_Mouse1.09848182
106IGF1R_20145208_ChIP-Seq_DFB_Human1.09695934
107TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08804420
108TCF4_22108803_ChIP-Seq_LS180_Human1.07554690
109ELK1_19687146_ChIP-ChIP_HELA_Human1.07512859
110NANOG_16153702_ChIP-ChIP_HESCs_Human1.07408846
111TP53_18474530_ChIP-ChIP_U2OS_Human1.07387340
112SMAD3_21741376_ChIP-Seq_ESCs_Human1.06925248
113CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.06099124
114POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.05933587
115TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05933587
116* AUTS2_25519132_ChIP-Seq_293T-REX_Human1.05133718
117SMAD4_21741376_ChIP-Seq_EPCs_Human1.04623482
118RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.04377812
119NR3C1_21868756_ChIP-Seq_MCF10A_Human1.03674035
120P53_22127205_ChIP-Seq_FIBROBLAST_Human1.03353095
121BCAT_22108803_ChIP-Seq_LS180_Human1.02639936
122YAP1_20516196_ChIP-Seq_MESCs_Mouse1.02593681
123RUNX2_22187159_ChIP-Seq_PCA_Human1.02253626
124GATA1_26923725_Chip-Seq_HPCs_Mouse1.01434353
125CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01117580
126TCF4_23295773_ChIP-Seq_U87_Human1.01108719
127* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.00527767
128FUS_26573619_Chip-Seq_HEK293_Human0.99436483
129* SMAD4_21741376_ChIP-Seq_HESCs_Human0.98824702
130NCOR_22424771_ChIP-Seq_293T_Human0.97535596
131MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.96583401
132VDR_22108803_ChIP-Seq_LS180_Human0.96363194
133TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96055629
134* JUN_21703547_ChIP-Seq_K562_Human0.94968078
135TP53_20018659_ChIP-ChIP_R1E_Mouse0.94846629
136CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.93750590
137RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.91345232
138TP53_16413492_ChIP-PET_HCT116_Human0.90796730
139PRDM14_20953172_ChIP-Seq_ESCs_Human0.90752396
140ER_23166858_ChIP-Seq_MCF-7_Human0.89745685
141TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.87513157
142* SMAD3_21741376_ChIP-Seq_HESCs_Human0.86708104
143TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.86654706
144KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.86291772
145KDM2B_26808549_Chip-Seq_REH_Human0.85978817

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.09510248
2MP0003880_abnormal_central_pattern3.87937952
3MP0003635_abnormal_synaptic_transmissio3.58085994
4MP0006292_abnormal_olfactory_placode3.32933989
5MP0004270_analgesia3.28094658
6MP0002063_abnormal_learning/memory/cond3.04264861
7MP0008877_abnormal_DNA_methylation3.02265108
8MP0009745_abnormal_behavioral_response2.89004307
9MP0001968_abnormal_touch/_nociception2.78289168
10MP0003646_muscle_fatigue2.75517062
11MP0002064_seizures2.57436018
12MP0002572_abnormal_emotion/affect_behav2.55857224
13MP0005423_abnormal_somatic_nervous2.54340294
14MP0002734_abnormal_mechanical_nocicepti2.50657914
15MP0009046_muscle_twitch2.50352104
16MP0001486_abnormal_startle_reflex2.50080154
17MP0001440_abnormal_grooming_behavior2.38071533
18MP0000778_abnormal_nervous_system2.31565122
19MP0002735_abnormal_chemical_nociception2.29646232
20MP0002736_abnormal_nociception_after2.19477876
21MP0006072_abnormal_retinal_apoptosis2.18421070
22MP0006276_abnormal_autonomic_nervous2.10671028
23MP0001485_abnormal_pinna_reflex2.09961094
24MP0004858_abnormal_nervous_system2.09755433
25MP0002733_abnormal_thermal_nociception1.96479651
26MP0001501_abnormal_sleep_pattern1.94345239
27MP0002272_abnormal_nervous_system1.94107449
28MP0002822_catalepsy1.90659809
29MP0003329_amyloid_beta_deposits1.88712752
30MP0004133_heterotaxia1.84205074
31MP0003890_abnormal_embryonic-extraembry1.82629169
32MP0002837_dystrophic_cardiac_calcinosis1.81617660
33MP0002184_abnormal_innervation1.81489631
34MP0009780_abnormal_chondrocyte_physiolo1.80318882
35MP0001984_abnormal_olfaction1.80256704
36MP0002557_abnormal_social/conspecific_i1.78770433
37MP0001970_abnormal_pain_threshold1.78143948
38MP0002067_abnormal_sensory_capabilities1.76535791
39MP0000049_abnormal_middle_ear1.74604326
40MP0004924_abnormal_behavior1.68111146
41MP0005386_behavior/neurological_phenoty1.68111146
42MP0003119_abnormal_digestive_system1.67166681
43MP0001293_anophthalmia1.55539922
44MP0003011_delayed_dark_adaptation1.50764796
45MP0003567_abnormal_fetal_cardiomyocyte1.49606021
46MP0003195_calcinosis1.47268092
47MP0005253_abnormal_eye_physiology1.47066048
48MP0000751_myopathy1.46679304
49MP0001529_abnormal_vocalization1.45951313
50MP0005646_abnormal_pituitary_gland1.43653505
51MP0003937_abnormal_limbs/digits/tail_de1.40141551
52MP0004811_abnormal_neuron_physiology1.38887027
53MP0003136_yellow_coat_color1.38411387
54MP0005389_reproductive_system_phenotype1.38387556
55MP0003718_maternal_effect1.36141150
56MP0000955_abnormal_spinal_cord1.35983311
57MP0002909_abnormal_adrenal_gland1.33289142
58MP0002160_abnormal_reproductive_system1.32990142
59MP0004145_abnormal_muscle_electrophysio1.32759294
60MP0002163_abnormal_gland_morphology1.32604164
61MP0003283_abnormal_digestive_organ1.31418647
62MP0002653_abnormal_ependyma_morphology1.30684220
63MP0002882_abnormal_neuron_morphology1.29538290
64MP0002638_abnormal_pupillary_reflex1.28913669
65MP0008569_lethality_at_weaning1.27684966
66MP0001919_abnormal_reproductive_system1.27195798
67MP0002938_white_spotting1.26451346
68MP0004147_increased_porphyrin_level1.25994863
69MP0003938_abnormal_ear_development1.25496792
70MP0002066_abnormal_motor_capabilities/c1.24156093
71MP0002876_abnormal_thyroid_physiology1.23793557
72MP0008058_abnormal_DNA_repair1.22930489
73MP0005645_abnormal_hypothalamus_physiol1.21965644
74MP0005551_abnormal_eye_electrophysiolog1.20791356
75MP0001502_abnormal_circadian_rhythm1.18974172
76MP0004885_abnormal_endolymph1.18187434
77MP0004215_abnormal_myocardial_fiber1.17815509
78MP0000372_irregular_coat_pigmentation1.16709954
79MP0003879_abnormal_hair_cell1.14143530
80MP0004142_abnormal_muscle_tone1.14030719
81MP0001905_abnormal_dopamine_level1.13217481
82MP0004085_abnormal_heartbeat1.12058708
83MP0005379_endocrine/exocrine_gland_phen1.10714194
84MP0001188_hyperpigmentation1.09853775
85MP0002152_abnormal_brain_morphology1.09720431
86MP0005195_abnormal_posterior_eye1.08637958
87MP0000604_amyloidosis1.08150152
88MP0002751_abnormal_autonomic_nervous1.06582868
89MP0008789_abnormal_olfactory_epithelium1.05789079
90MP0005171_absent_coat_pigmentation1.05156947
91MP0009379_abnormal_foot_pigmentation1.04116383
92MP0003137_abnormal_impulse_conducting1.03725703
93MP0005377_hearing/vestibular/ear_phenot1.00879177
94MP0003878_abnormal_ear_physiology1.00879177
95MP0002138_abnormal_hepatobiliary_system0.99098041
96MP0004484_altered_response_of0.98833629
97MP0001986_abnormal_taste_sensitivity0.98828155
98MP0003633_abnormal_nervous_system0.98185263
99MP0000569_abnormal_digit_pigmentation0.96618984
100MP0003631_nervous_system_phenotype0.91172766
101MP0002069_abnormal_eating/drinking_beha0.91135672
102MP0004742_abnormal_vestibular_system0.89612298
103MP0005187_abnormal_penis_morphology0.89264147
104MP0002090_abnormal_vision0.87942106
105MP0002254_reproductive_system_inflammat0.87556387
106MP0003122_maternal_imprinting0.87187228
107MP0005085_abnormal_gallbladder_physiolo0.85409796
108MP0002277_abnormal_respiratory_mucosa0.85014505
109MP0003690_abnormal_glial_cell0.84956389
110MP0004130_abnormal_muscle_cell0.83680353
111MP0002139_abnormal_hepatobiliary_system0.83608528
112MP0008874_decreased_physiological_sensi0.83017925
113MP0003121_genomic_imprinting0.83009288
114MP0009250_abnormal_appendicular_skeleto0.82827243
115MP0001963_abnormal_hearing_physiology0.82703810
116MP0002752_abnormal_somatic_nervous0.81547325
117MP0003634_abnormal_glial_cell0.80689759
118MP0000631_abnormal_neuroendocrine_gland0.80536025
119MP0005535_abnormal_body_temperature0.80476736
120MP0001177_atelectasis0.79930577
121MP0005174_abnormal_tail_pigmentation0.75080866
122MP0008872_abnormal_physiological_respon0.75013840
123MP0000383_abnormal_hair_follicle0.73989190
124MP0005084_abnormal_gallbladder_morpholo0.73407598
125MP0005391_vision/eye_phenotype0.72744674
126MP0003632_abnormal_nervous_system0.71656610
127MP0005394_taste/olfaction_phenotype0.71596453
128MP0005499_abnormal_olfactory_system0.71596453
129MP0000026_abnormal_inner_ear0.70865860
130MP0002102_abnormal_ear_morphology0.70036935
131MP0002229_neurodegeneration0.68176749
132MP0005620_abnormal_muscle_contractility0.68091739
133MP0005360_urolithiasis0.67234133
134MP0001664_abnormal_digestion0.66987070
135MP0005623_abnormal_meninges_morphology0.66983394
136MP0005248_abnormal_Harderian_gland0.66158664
137MP0003861_abnormal_nervous_system0.65237587
138MP0003787_abnormal_imprinting0.64572545
139MP0010329_abnormal_lipoprotein_level0.63950978
140MP0010386_abnormal_urinary_bladder0.63829855
141MP0000013_abnormal_adipose_tissue0.63251042
142MP0005595_abnormal_vascular_smooth0.61158489
143MP0005365_abnormal_bile_salt0.59772851
144MP0005409_darkened_coat_color0.56469332
145MP0008875_abnormal_xenobiotic_pharmacok0.55371625
146MP0004883_abnormal_blood_vessel0.54670633

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.28742370
2Myokymia (HP:0002411)4.99581658
3Focal seizures (HP:0007359)4.99430086
4Epileptic encephalopathy (HP:0200134)4.67202109
5Hyperventilation (HP:0002883)4.47390382
6Visual hallucinations (HP:0002367)4.18980371
7Febrile seizures (HP:0002373)3.80771959
8Mutism (HP:0002300)3.52232665
9Progressive cerebellar ataxia (HP:0002073)3.51784042
10Generalized tonic-clonic seizures (HP:0002069)3.51673285
11Atonic seizures (HP:0010819)3.48981367
12Pancreatic cysts (HP:0001737)3.47597877
13Congenital stationary night blindness (HP:0007642)3.45349273
14Pancreatic fibrosis (HP:0100732)3.40754271
15Absence seizures (HP:0002121)3.38653711
16Broad-based gait (HP:0002136)3.34576585
17Abolished electroretinogram (ERG) (HP:0000550)3.31554302
18Polyphagia (HP:0002591)3.30133971
19Stenosis of the external auditory canal (HP:0000402)3.23776795
20Drooling (HP:0002307)3.22931877
21Excessive salivation (HP:0003781)3.22931877
22Dialeptic seizures (HP:0011146)3.21939810
23Pendular nystagmus (HP:0012043)3.14223043
24Neurofibrillary tangles (HP:0002185)3.13588131
25Cerebral inclusion bodies (HP:0100314)3.12324673
26Septo-optic dysplasia (HP:0100842)3.10854937
27True hermaphroditism (HP:0010459)3.08520371
28Abnormality of midbrain morphology (HP:0002418)3.08037681
29Molar tooth sign on MRI (HP:0002419)3.08037681
30Limb dystonia (HP:0002451)3.01643288
31Supranuclear gaze palsy (HP:0000605)2.96833192
32Nephronophthisis (HP:0000090)2.96831156
33Amblyopia (HP:0000646)2.95703793
34Poor eye contact (HP:0000817)2.94952175
35Impaired social interactions (HP:0000735)2.83678894
36Abnormal social behavior (HP:0012433)2.83678894
37Abnormality of the middle phalanges of the toes (HP:0010183)2.79755562
38Abnormality of the corticospinal tract (HP:0002492)2.79354130
39Ankle clonus (HP:0011448)2.78970678
40Hemiparesis (HP:0001269)2.77267150
41Short hallux (HP:0010109)2.76458989
42Abnormality of the labia minora (HP:0012880)2.75669441
43Abnormal eating behavior (HP:0100738)2.74149044
44Blue irides (HP:0000635)2.65975277
45Aplasia/Hypoplasia of the hallux (HP:0008362)2.64754841
46Torticollis (HP:0000473)2.58119955
47Epileptiform EEG discharges (HP:0011182)2.55352624
48Methylmalonic acidemia (HP:0002912)2.54710737
49EEG with generalized epileptiform discharges (HP:0011198)2.49428575
50Status epilepticus (HP:0002133)2.47690907
51Abnormality of the proximal phalanges of the hand (HP:0009834)2.47180129
52Acute necrotizing encephalopathy (HP:0006965)2.45187208
53Action tremor (HP:0002345)2.45109759
54Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.44122722
55Absent speech (HP:0001344)2.41877482
56Hypsarrhythmia (HP:0002521)2.41103212
57Impaired vibration sensation in the lower limbs (HP:0002166)2.40366419
58Termporal pattern (HP:0011008)2.38219992
59Insidious onset (HP:0003587)2.38219992
60Dysdiadochokinesis (HP:0002075)2.36950811
61Abnormality of the renal medulla (HP:0100957)2.36226174
62Colon cancer (HP:0003003)2.35335533
63Congenital, generalized hypertrichosis (HP:0004540)2.34965983
64Asplenia (HP:0001746)2.34604482
65Diplopia (HP:0000651)2.32761518
66Abnormality of binocular vision (HP:0011514)2.32761518
67Aplasia/Hypoplasia of the spleen (HP:0010451)2.30717143
68Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.29835303
69Abnormality of alanine metabolism (HP:0010916)2.29835303
70Hyperalaninemia (HP:0003348)2.29835303
71Abnormality of the phalanges of the 2nd finger (HP:0009541)2.28130707
72Optic nerve hypoplasia (HP:0000609)2.27493955
73Akinesia (HP:0002304)2.27424101
74Anxiety (HP:0000739)2.26558119
75Inability to walk (HP:0002540)2.26281465
76Exotropia (HP:0000577)2.25561739
77Amyotrophic lateral sclerosis (HP:0007354)2.22830190
78Urinary bladder sphincter dysfunction (HP:0002839)2.22559288
79Fetal akinesia sequence (HP:0001989)2.22142398
80Sclerocornea (HP:0000647)2.21120405
81Hyperglycinemia (HP:0002154)2.20948480
82Acute encephalopathy (HP:0006846)2.20900703
83Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.20016242
84Type II lissencephaly (HP:0007260)2.18122712
85Decreased central vision (HP:0007663)2.17812019
86Protruding tongue (HP:0010808)2.17721663
87Focal dystonia (HP:0004373)2.16965755
88Megalencephaly (HP:0001355)2.15600895
89Progressive inability to walk (HP:0002505)2.15448959
90Depression (HP:0000716)2.14763827
91Hyperthyroidism (HP:0000836)2.14719116
92Progressive macrocephaly (HP:0004481)2.14639989
93Abnormal rod and cone electroretinograms (HP:0008323)2.14585254
94Truncal ataxia (HP:0002078)2.14022658
95Keratoconus (HP:0000563)2.13103009
96Increased corneal curvature (HP:0100692)2.13103009
97Generalized myoclonic seizures (HP:0002123)2.13102718
98Morphological abnormality of the pyramidal tract (HP:0002062)2.12500996
99Medial flaring of the eyebrow (HP:0010747)2.12459261
100Decreased electroretinogram (ERG) amplitude (HP:0000654)2.12403714
101Methylmalonic aciduria (HP:0012120)2.11302107
102Cystic liver disease (HP:0006706)2.11211663
103Urinary urgency (HP:0000012)2.09948329
104Chorioretinal atrophy (HP:0000533)2.09906366
105Abnormality of salivation (HP:0100755)2.09604229
106Abnormality of the renal collecting system (HP:0004742)2.08165594
107Gaze-evoked nystagmus (HP:0000640)2.07516036
108Abnormality of the ileum (HP:0001549)2.07476789
109Aplasia/Hypoplasia of the uvula (HP:0010293)2.07175964
110Absent rod-and cone-mediated responses on ERG (HP:0007688)2.07065956
111Absent thumb (HP:0009777)2.06844677
112Craniofacial dystonia (HP:0012179)2.06652618
113Abnormality of the phalanges of the 5th finger (HP:0004213)2.06310948
114Mitochondrial inheritance (HP:0001427)2.05780067
115Attenuation of retinal blood vessels (HP:0007843)2.04940670
116Stomach cancer (HP:0012126)2.03310796
117Meckel diverticulum (HP:0002245)2.03005595
118Abnormality of the lower motor neuron (HP:0002366)2.02143717
119Abnormal mitochondria in muscle tissue (HP:0008316)2.02139408
120Dysmetria (HP:0001310)2.00209482
121Agitation (HP:0000713)1.99811015
122Spastic gait (HP:0002064)1.99200976
123Lower limb muscle weakness (HP:0007340)1.98817627
124Pachygyria (HP:0001302)1.97678994
125Hemiplegia (HP:0002301)1.97228315
126Hypoplasia of the pons (HP:0012110)1.96631554
127Lower limb amyotrophy (HP:0007210)1.94958615
128Increased CSF lactate (HP:0002490)1.94797406
129Gait imbalance (HP:0002141)1.94633809
130Morphological abnormality of the middle ear (HP:0008609)1.94031270
131Stereotypic behavior (HP:0000733)1.93998998
132Bony spicule pigmentary retinopathy (HP:0007737)1.92535732
133Hepatoblastoma (HP:0002884)1.91167687
134Aplasia/Hypoplasia of the brainstem (HP:0007362)1.90523004
135Hypoplasia of the brainstem (HP:0002365)1.90523004
136Bradycardia (HP:0001662)1.90432148
137Aplasia/Hypoplasia of the tibia (HP:0005772)1.90366546
138Intestinal atresia (HP:0011100)1.90038405
139Inappropriate behavior (HP:0000719)1.90015213
140Genetic anticipation (HP:0003743)1.89732922
141Abnormality of the renal cortex (HP:0011035)1.89326076
142Short 1st metacarpal (HP:0010034)1.89253250
143Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.89253250
144Anencephaly (HP:0002323)1.88989349
145Abnormality of cochlea (HP:0000375)1.87006278
146Humeroradial synostosis (HP:0003041)1.86346617
147Synostosis involving the elbow (HP:0003938)1.86346617
148Abnormality of the pons (HP:0007361)1.85858295
149Supernumerary spleens (HP:0009799)1.85617088
150Symphalangism affecting the phalanges of the hand (HP:0009773)1.85589775
151Absent septum pellucidum (HP:0001331)1.84762437
152Maternal diabetes (HP:0009800)1.84742816
153Chronic hepatic failure (HP:0100626)1.84336717
154Fair hair (HP:0002286)1.79149672
155Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.78464658
156Narrow nasal bridge (HP:0000446)1.78321609
157IgG deficiency (HP:0004315)1.78303944
158Abnormal drinking behavior (HP:0030082)1.77374985
159Polydipsia (HP:0001959)1.77374985
160Abnormality of serum amino acid levels (HP:0003112)1.77119923
161Abnormality of glycine metabolism (HP:0010895)1.76937501
162Abnormality of serine family amino acid metabolism (HP:0010894)1.76937501
163Abnormal biliary tract physiology (HP:0012439)1.75601257
164Bile duct proliferation (HP:0001408)1.75601257
165Genital tract atresia (HP:0001827)1.75483384
166Hypoplasia of the uterus (HP:0000013)1.75459620
167Vaginal atresia (HP:0000148)1.75411881
168Hypoventilation (HP:0002791)1.74804726
169Syncope (HP:0001279)1.74652591
170Synostosis of carpal bones (HP:0005048)1.74444196
171Deep venous thrombosis (HP:0002625)1.74377625
172Postural instability (HP:0002172)1.73748712
173Carpal bone hypoplasia (HP:0001498)1.73693716
174Hypoplasia of the ulna (HP:0003022)1.73595505
175Aplasia/Hypoplasia of the sternum (HP:0006714)1.73107820
176Sleep apnea (HP:0010535)1.73037489
177Short tibia (HP:0005736)1.72803052
178Obstructive sleep apnea (HP:0002870)1.71765455
179Anosmia (HP:0000458)1.69583279
180Spastic tetraplegia (HP:0002510)1.67161873
181Esotropia (HP:0000565)1.64596304
182Failure to thrive in infancy (HP:0001531)1.63635895
183Specific learning disability (HP:0001328)1.62934373
184Palpebral edema (HP:0100540)1.62838866
185Neuronal loss in central nervous system (HP:0002529)1.62443626
186Lissencephaly (HP:0001339)1.61712999
187Clumsiness (HP:0002312)1.59581122
188Scanning speech (HP:0002168)1.59516228
189Pheochromocytoma (HP:0002666)1.58604176
190Gait ataxia (HP:0002066)1.57971055
191Bradykinesia (HP:0002067)1.57675338

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK15.30463778
2FRK3.41057692
3NTRK33.37874326
4MAP3K93.26987187
5EPHA43.23563013
6CASK3.14430301
7GRK12.89928757
8MAP3K42.88771388
9ADRBK22.76952518
10MAP2K72.66911896
11BMPR1B2.61501527
12ZAK2.59042501
13NTRK22.44196194
14DAPK22.37929118
15NUAK12.33531987
16MAP4K22.25223832
17TLK12.20300503
18MINK12.17229967
19PHKG12.16854151
20PHKG22.16854151
21MAP2K42.01984051
22MAPK132.01371784
23LATS21.94531929
24PAK61.90544280
25ACVR1B1.90110304
26SIK21.87145509
27BUB11.82371106
28CDC71.69019749
29MKNK21.68232968
30TNIK1.64330367
31TAF11.64087167
32WNK41.63518797
33TIE11.58816185
34PLK21.57581275
35CDK191.56378362
36KSR11.51972827
37OXSR11.50555716
38PLK41.50305965
39STK161.41808698
40GRK51.41113979
41NTRK11.37167831
42DYRK21.36994690
43CDK51.31179397
44VRK21.28757464
45MAP3K121.22042898
46PLK31.20216482
47TXK1.20107532
48EPHB21.16385357
49NEK11.15646234
50PRKD31.14361139
51PRKCG1.12281560
52TAOK31.12214071
53MAPK121.10763994
54MKNK11.10105498
55BCKDK1.09797201
56CSNK1G11.08548207
57PNCK1.06943951
58VRK11.06112502
59PAK31.05827747
60CAMKK11.05659398
61MAP3K61.03462427
62KSR21.02056979
63CAMK2A1.01158187
64ERBB31.00616594
65STK390.97751651
66DAPK10.96776188
67PKN10.96133010
68LMTK20.95449704
69DYRK1A0.94367744
70CSNK1G30.91583594
71PRPF4B0.89050275
72TYRO30.88098947
73CSNK1G20.82173712
74MARK20.81358378
75PRKCE0.79501907
76PLK10.79171377
77CAMK1G0.78414212
78UHMK10.77810731
79TGFBR10.77244549
80FGFR20.76742119
81TRIM280.76499736
82STK110.73110160
83TTK0.72857115
84PRKCZ0.72690127
85STK380.71821561
86STK38L0.70422915
87CSNK1A1L0.70245857
88NEK20.70155366
89RET0.68900953
90SGK2230.68502612
91SGK4940.68502612
92CDK180.66164282
93PRKCH0.64756764
94CCNB10.64630794
95CAMK10.64501914
96TSSK60.64461060
97PTK2B0.64374736
98CDK150.64013514
99CDK140.63150715
100AKT30.62158931
101RIPK40.60613683
102CSNK1A10.60379427
103SGK20.58685877
104MAPKAPK50.58277141
105TEC0.58115041
106ERBB40.57622984
107CHEK20.57028085
108SGK10.56578954
109CAMK2B0.55593776
110DYRK30.55368310
111FGR0.54666547
112CAMKK20.54272721
113MAPK70.53848842
114SRPK10.53823483
115MAP3K20.53053204
116RPS6KA50.52478909
117CDK11A0.52257541
118ATR0.52100280
119GRK70.51909038
120MAP2K10.51311843
121PRKACA0.49928174
122MUSK0.48559915
123BMPR20.48285556
124ADRBK10.48032268
125LIMK10.47136837
126FER0.47019742
127TAOK10.46278281
128SIK30.45486413
129KDR0.44955486
130NME10.43709441
131NLK0.42811097
132MST40.42668153
133BRSK20.42421302
134FES0.41426289
135INSRR0.41167433
136RPS6KA30.40109772
137CSNK1D0.40037823
138PINK10.38644476
139CAMK40.38332892
140PIM10.38029260
141PRKG10.38023742
142PRKCI0.38004082
143PRKCA0.37958623
144ROCK10.37493262
145STK30.37211162
146FYN0.36751617
147PDGFRA0.36711845
148MAPK40.36619899
149ARAF0.36602262
150MAP2K60.36474413
151SGK30.36072285
152MAP3K70.35583684
153CAMK2G0.35374708
154WNK30.35249255
155CDC42BPA0.34722792
156CSNK2A10.34668027
157BCR0.34619668
158PDPK10.33570243

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.48390870
2Synaptic vesicle cycle_Homo sapiens_hsa047212.58293816
3GABAergic synapse_Homo sapiens_hsa047272.44107786
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.39162597
5RNA polymerase_Homo sapiens_hsa030202.38965650
6Homologous recombination_Homo sapiens_hsa034402.33430335
7Parkinsons disease_Homo sapiens_hsa050122.29313036
8Circadian entrainment_Homo sapiens_hsa047132.20987323
9Glutamatergic synapse_Homo sapiens_hsa047242.20520900
10Morphine addiction_Homo sapiens_hsa050322.19622004
11Ribosome_Homo sapiens_hsa030102.17688349
12Olfactory transduction_Homo sapiens_hsa047402.13736019
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.90897708
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.84517466
15Long-term potentiation_Homo sapiens_hsa047201.83650163
16Selenocompound metabolism_Homo sapiens_hsa004501.82509416
17Basal transcription factors_Homo sapiens_hsa030221.82104163
18Amphetamine addiction_Homo sapiens_hsa050311.81410981
19Nitrogen metabolism_Homo sapiens_hsa009101.78758097
20RNA degradation_Homo sapiens_hsa030181.77175806
21Dopaminergic synapse_Homo sapiens_hsa047281.77086869
22Fanconi anemia pathway_Homo sapiens_hsa034601.75332140
23Protein export_Homo sapiens_hsa030601.71080963
24Linoleic acid metabolism_Homo sapiens_hsa005911.70075143
25Taste transduction_Homo sapiens_hsa047421.65720872
26Salivary secretion_Homo sapiens_hsa049701.64372862
27Cholinergic synapse_Homo sapiens_hsa047251.60999609
28Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.59211843
29Axon guidance_Homo sapiens_hsa043601.59105701
30Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.56665358
31Huntingtons disease_Homo sapiens_hsa050161.55128463
32alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.54371210
33Serotonergic synapse_Homo sapiens_hsa047261.53826324
34Proteasome_Homo sapiens_hsa030501.53502207
35Insulin secretion_Homo sapiens_hsa049111.52429347
36Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.50352159
37Renin secretion_Homo sapiens_hsa049241.44095204
38Aldosterone synthesis and secretion_Homo sapiens_hsa049251.40966627
39Calcium signaling pathway_Homo sapiens_hsa040201.38103383
40Cocaine addiction_Homo sapiens_hsa050301.36940504
41Long-term depression_Homo sapiens_hsa047301.36891043
42Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.36681425
43Butanoate metabolism_Homo sapiens_hsa006501.35163754
44Oxytocin signaling pathway_Homo sapiens_hsa049211.34572288
45One carbon pool by folate_Homo sapiens_hsa006701.32672771
46Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.30844066
47Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.29745304
48Gastric acid secretion_Homo sapiens_hsa049711.29184013
49Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.22627690
50Ether lipid metabolism_Homo sapiens_hsa005651.17983235
51Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.15691905
52Gap junction_Homo sapiens_hsa045401.15616586
53GnRH signaling pathway_Homo sapiens_hsa049121.14138594
54Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.12936236
55Sulfur metabolism_Homo sapiens_hsa009201.12646093
56Arginine biosynthesis_Homo sapiens_hsa002201.12175465
57Collecting duct acid secretion_Homo sapiens_hsa049661.10985266
58Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.10610342
59Mismatch repair_Homo sapiens_hsa034301.05471305
60DNA replication_Homo sapiens_hsa030301.05378655
61cAMP signaling pathway_Homo sapiens_hsa040241.04276739
62Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.02812763
63Cysteine and methionine metabolism_Homo sapiens_hsa002701.02711380
64Retinol metabolism_Homo sapiens_hsa008301.02332119
65Maturity onset diabetes of the young_Homo sapiens_hsa049501.01451560
66Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.01082511
67Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.99695289
68ErbB signaling pathway_Homo sapiens_hsa040120.96435669
69Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.96377589
70Phototransduction_Homo sapiens_hsa047440.95780393
71Melanogenesis_Homo sapiens_hsa049160.95445098
72Bile secretion_Homo sapiens_hsa049760.95421704
73Cardiac muscle contraction_Homo sapiens_hsa042600.94683322
74Purine metabolism_Homo sapiens_hsa002300.93613717
75Primary bile acid biosynthesis_Homo sapiens_hsa001200.92561002
76Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.92081526
77Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.91996240
78Dorso-ventral axis formation_Homo sapiens_hsa043200.89382888
79Chemical carcinogenesis_Homo sapiens_hsa052040.89169251
80Non-homologous end-joining_Homo sapiens_hsa034500.87865471
81Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.86934392
82cGMP-PKG signaling pathway_Homo sapiens_hsa040220.86745635
83Dilated cardiomyopathy_Homo sapiens_hsa054140.85905274
84Glioma_Homo sapiens_hsa052140.85339978
85Nucleotide excision repair_Homo sapiens_hsa034200.83206052
86Estrogen signaling pathway_Homo sapiens_hsa049150.83105964
87Sulfur relay system_Homo sapiens_hsa041220.81643332
88RNA transport_Homo sapiens_hsa030130.81457559
89Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.81034735
90Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.80864861
91Caffeine metabolism_Homo sapiens_hsa002320.80317769
92Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.79908174
93Vascular smooth muscle contraction_Homo sapiens_hsa042700.79748841
94Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.79661845
95Type II diabetes mellitus_Homo sapiens_hsa049300.79207484
96Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.78668685
97Pyrimidine metabolism_Homo sapiens_hsa002400.76162929
98Complement and coagulation cascades_Homo sapiens_hsa046100.73810261
99Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.73300611
100Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.73112017
101Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.71948825
102Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.71688830
103Basal cell carcinoma_Homo sapiens_hsa052170.69937573
104Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.69910685
105Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.69710923
106Glycerolipid metabolism_Homo sapiens_hsa005610.67190623
107Arachidonic acid metabolism_Homo sapiens_hsa005900.66796062
108Hedgehog signaling pathway_Homo sapiens_hsa043400.66650944
109Spliceosome_Homo sapiens_hsa030400.65865772
110Regulation of autophagy_Homo sapiens_hsa041400.64707360
111Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.64435526
112Vitamin B6 metabolism_Homo sapiens_hsa007500.64068222
113Histidine metabolism_Homo sapiens_hsa003400.64005536
114Fat digestion and absorption_Homo sapiens_hsa049750.63712898
115PPAR signaling pathway_Homo sapiens_hsa033200.62731686
116Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.61298761
117Vibrio cholerae infection_Homo sapiens_hsa051100.60119906
118Ras signaling pathway_Homo sapiens_hsa040140.59577697
119Prion diseases_Homo sapiens_hsa050200.59423483
120Metabolic pathways_Homo sapiens_hsa011000.58720187
121beta-Alanine metabolism_Homo sapiens_hsa004100.57715199
122Pentose and glucuronate interconversions_Homo sapiens_hsa000400.56898461
123Glucagon signaling pathway_Homo sapiens_hsa049220.56712720
124Phospholipase D signaling pathway_Homo sapiens_hsa040720.56699084
125Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.55672019
126Fatty acid metabolism_Homo sapiens_hsa012120.55245814
127Peroxisome_Homo sapiens_hsa041460.54955733
128Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.53746397
129Base excision repair_Homo sapiens_hsa034100.53446958
130Vitamin digestion and absorption_Homo sapiens_hsa049770.53193682
131Ovarian steroidogenesis_Homo sapiens_hsa049130.52755540
132Fatty acid biosynthesis_Homo sapiens_hsa000610.52238456
133Choline metabolism in cancer_Homo sapiens_hsa052310.50142611
134Steroid biosynthesis_Homo sapiens_hsa001000.49699628
135Primary immunodeficiency_Homo sapiens_hsa053400.49162148
136MAPK signaling pathway_Homo sapiens_hsa040100.48913324
137Thyroid hormone synthesis_Homo sapiens_hsa049180.48070169
138Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.47842649
139Rap1 signaling pathway_Homo sapiens_hsa040150.47533842
140Intestinal immune network for IgA production_Homo sapiens_hsa046720.46507574
141Phosphatidylinositol signaling system_Homo sapiens_hsa040700.43644191
142Alzheimers disease_Homo sapiens_hsa050100.41598363
143Wnt signaling pathway_Homo sapiens_hsa043100.41363345
144Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.41307017
145Renal cell carcinoma_Homo sapiens_hsa052110.40563912
146Tryptophan metabolism_Homo sapiens_hsa003800.38539979
147Insulin signaling pathway_Homo sapiens_hsa049100.38517861
148Endometrial cancer_Homo sapiens_hsa052130.37375494
149Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.37166858
150Steroid hormone biosynthesis_Homo sapiens_hsa001400.35016877
151African trypanosomiasis_Homo sapiens_hsa051430.33496371
152Pancreatic secretion_Homo sapiens_hsa049720.32551798
153Sphingolipid signaling pathway_Homo sapiens_hsa040710.32253183
154Longevity regulating pathway - mammal_Homo sapiens_hsa042110.31332640
155Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.30368077
156Thyroid hormone signaling pathway_Homo sapiens_hsa049190.29533743
157Melanoma_Homo sapiens_hsa052180.28532870
158Propanoate metabolism_Homo sapiens_hsa006400.28376471
159Oxidative phosphorylation_Homo sapiens_hsa001900.25601292

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