FAM124B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein K11-linked deubiquitination (GO:0035871)9.67335612
2regulation of T-helper 1 cell differentiation (GO:0045625)9.43730324
3negative regulation of type 2 immune response (GO:0002829)8.69514451
4activation of protein kinase A activity (GO:0034199)8.63031700
5regulation of T-helper 2 cell differentiation (GO:0045628)8.62679862
6positive regulation of RNA splicing (GO:0033120)8.54430953
7cAMP biosynthetic process (GO:0006171)8.19517881
8detection of chemical stimulus involved in sensory perception (GO:0050907)7.89164006
9definitive hemopoiesis (GO:0060216)7.81115946
10negative regulation of alpha-beta T cell differentiation (GO:0046639)7.71620186
11enteric nervous system development (GO:0048484)7.27194227
12endothelial cell differentiation (GO:0045446)6.96777006
13positive regulation of mitochondrial fission (GO:0090141)6.90929176
14synaptic transmission, dopaminergic (GO:0001963)6.79516285
15regulation of protein sumoylation (GO:0033233)6.61760899
16dendritic spine morphogenesis (GO:0060997)6.59915328
17righting reflex (GO:0060013)6.45904585
18positive regulation of defense response to virus by host (GO:0002230)6.30226331
19cell wall macromolecule metabolic process (GO:0044036)6.19018595
20cell wall macromolecule catabolic process (GO:0016998)6.19018595
21positive regulation of T-helper 1 type immune response (GO:0002827)6.01364209
22polyketide metabolic process (GO:0030638)5.99711729
23doxorubicin metabolic process (GO:0044598)5.99711729
24daunorubicin metabolic process (GO:0044597)5.99711729
25heterotypic cell-cell adhesion (GO:0034113)5.86452508
26endothelium development (GO:0003158)5.79846721
27detection of chemical stimulus (GO:0009593)5.70584760
28icosanoid secretion (GO:0032309)5.68432971
29arachidonic acid secretion (GO:0050482)5.68432971
30positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)5.57861004
31morphogenesis of an endothelium (GO:0003159)5.50837744
32endothelial tube morphogenesis (GO:0061154)5.50837744
33phosphatidylinositol acyl-chain remodeling (GO:0036149)5.37663689
34positive regulation of T-helper cell differentiation (GO:0045624)5.31986627
35hepatocyte apoptotic process (GO:0097284)5.20460998
36positive regulation of gamma-delta T cell activation (GO:0046645)5.18454536
37megakaryocyte development (GO:0035855)5.17547139
38drug transmembrane transport (GO:0006855)5.03663759
39regulation of mitochondrial fission (GO:0090140)5.00014496
40response to muramyl dipeptide (GO:0032495)4.93681917
41regulation of isotype switching to IgG isotypes (GO:0048302)4.90814344
42negative T cell selection (GO:0043383)4.89941846
43seminiferous tubule development (GO:0072520)4.89732106
44phosphatidylserine acyl-chain remodeling (GO:0036150)4.83721380
45hyaluronan catabolic process (GO:0030214)4.79982364
46negative thymic T cell selection (GO:0045060)4.69281408
47icosanoid transport (GO:0071715)4.64457808
48fatty acid derivative transport (GO:1901571)4.64457808
49regulation of syncytium formation by plasma membrane fusion (GO:0060142)4.63785610
50neural tube formation (GO:0001841)4.60319697
51chemosensory behavior (GO:0007635)4.58712650
52cilium or flagellum-dependent cell motility (GO:0001539)4.47211951
53nephron epithelium morphogenesis (GO:0072088)4.46842400
54nephron tubule morphogenesis (GO:0072078)4.46842400
55negative regulation of T cell mediated immunity (GO:0002710)4.45974828
56negative regulation of alpha-beta T cell activation (GO:0046636)4.44514816
57oocyte maturation (GO:0001556)4.44307996
58phosphatidylglycerol acyl-chain remodeling (GO:0036148)4.42331012
59regulation of T-helper 1 type immune response (GO:0002825)4.40349888
60retina layer formation (GO:0010842)4.40317121
613-UTR-mediated mRNA stabilization (GO:0070935)4.34307096
62cyclic purine nucleotide metabolic process (GO:0052652)4.27706929
63response to protozoan (GO:0001562)4.21878900
64cyclic nucleotide biosynthetic process (GO:0009190)4.19435870
65negative regulation of cytosolic calcium ion concentration (GO:0051481)4.11249334
66negative regulation of actin filament bundle assembly (GO:0032232)4.10273959
67positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)4.07680883
68regulation of gamma-delta T cell activation (GO:0046643)4.06756590
69defense response to protozoan (GO:0042832)4.04507536
70vocalization behavior (GO:0071625)4.03605096
71positive regulation of heterotypic cell-cell adhesion (GO:0034116)4.03169767
72cytokine production involved in immune response (GO:0002367)4.01345490
73positive regulation of DNA biosynthetic process (GO:2000573)3.96809002
74neuronal ion channel clustering (GO:0045161)3.94975830
75energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.93423367
76ATP hydrolysis coupled proton transport (GO:0015991)3.93423367
77positive regulation of membrane potential (GO:0045838)3.93246597
78regulation of gamma-delta T cell differentiation (GO:0045586)3.92482979
79positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.91813767
80cAMP metabolic process (GO:0046058)3.91192407
81renal tubule morphogenesis (GO:0061333)3.87664830
82regulation of T-helper cell differentiation (GO:0045622)3.83285583
83regulation of cAMP-mediated signaling (GO:0043949)3.79078216
84embryonic digestive tract morphogenesis (GO:0048557)3.76946886
85positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.76084519
86attachment of spindle microtubules to kinetochore (GO:0008608)3.74951644
87cellular response to ATP (GO:0071318)3.70597334
88dendritic spine organization (GO:0097061)3.67502485
89regulation of MHC class II biosynthetic process (GO:0045346)3.65137275
90response to dietary excess (GO:0002021)3.64092427
91cellular response to interleukin-15 (GO:0071350)3.63801039
92water transport (GO:0006833)3.61903233
93positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)3.58296199
94protein localization to synapse (GO:0035418)3.54679813
95phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.51968231
96thymic T cell selection (GO:0045061)3.51868400
97left/right axis specification (GO:0070986)3.51753910
98osteoclast differentiation (GO:0030316)3.51077919
99aminoglycoside antibiotic metabolic process (GO:0030647)3.50929787
100negative regulation of T-helper cell differentiation (GO:0045623)3.50824343
101negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.50824343
102negative regulation of T cell differentiation (GO:0045581)3.49053846
103monoamine transport (GO:0015844)3.49037338
104lens morphogenesis in camera-type eye (GO:0002089)3.47622451
105T cell selection (GO:0045058)3.47580949
106response to interleukin-15 (GO:0070672)3.45770934
107cellular response to glucagon stimulus (GO:0071377)3.45674953
108embryonic hemopoiesis (GO:0035162)3.39195627
109leukotriene biosynthetic process (GO:0019370)3.38248792
110interferon-gamma production (GO:0032609)3.38040498
111exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.36968724
112positive regulation of steroid hormone secretion (GO:2000833)3.36077817
113regulation of type 2 immune response (GO:0002828)3.35730893
114reflex (GO:0060004)3.33948958
115positive regulation of erythrocyte differentiation (GO:0045648)3.32955684
116drug transport (GO:0015893)3.29888921
117fluid transport (GO:0042044)3.29547767
118production of molecular mediator of immune response (GO:0002440)3.28723548
119positive regulation of myoblast differentiation (GO:0045663)3.28614369
120reciprocal DNA recombination (GO:0035825)3.27305458
121reciprocal meiotic recombination (GO:0007131)3.27305458
122regulation of defense response to virus by host (GO:0050691)3.26862938
123positive T cell selection (GO:0043368)3.26027988
124regulation of activation of Janus kinase activity (GO:0010533)3.24290004
125positive regulation of respiratory burst (GO:0060267)3.21972645
126blood vessel maturation (GO:0001955)3.20636839
127positive regulation of CREB transcription factor activity (GO:0032793)3.20098025
128positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)3.19174933
129positive regulation of chemokine biosynthetic process (GO:0045080)3.18994481
130adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway (GO:0007193)3.18890097
131mitochondrial fusion (GO:0008053)3.17250434
132negative regulation of nitric oxide biosynthetic process (GO:0045019)3.16134379
133positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.14077599
134positive regulation of alpha-beta T cell differentiation (GO:0046638)3.13760258
135CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.13494788
136T cell migration (GO:0072678)3.13315884
137nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.13150521
138hindbrain development (GO:0030902)3.13050217
139positive regulation of interleukin-2 production (GO:0032743)3.10307304
140cellular response to exogenous dsRNA (GO:0071360)3.09762349
141regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.09430960
142regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.09430960
143positive regulation of histone deacetylation (GO:0031065)3.08968554
144homeostasis of number of cells within a tissue (GO:0048873)3.08899146
145lymphangiogenesis (GO:0001946)3.07600746
146positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)3.06817018
147male meiosis I (GO:0007141)3.04402844
148myoblast differentiation (GO:0045445)3.04077563
149regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.03427939
150CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.02998876
151T-helper cell differentiation (GO:0042093)3.02998876
152sulfur amino acid catabolic process (GO:0000098)3.02871604
153regulation of B cell receptor signaling pathway (GO:0050855)3.02198140
154negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.01359051
155sequestering of metal ion (GO:0051238)3.00682268
156phosphatidylcholine acyl-chain remodeling (GO:0036151)2.99632155
157regulation of chronic inflammatory response (GO:0002676)2.99384669
158regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.98393811
159positive regulation of protein targeting to membrane (GO:0090314)2.98060846
160regulation of telomere maintenance via telomerase (GO:0032210)2.97615072
161positive regulation of isotype switching (GO:0045830)2.96987428
162cellular zinc ion homeostasis (GO:0006882)2.95360194
163positive regulation of interleukin-17 production (GO:0032740)2.93406199
164positive regulation of humoral immune response (GO:0002922)2.91564331
165positive regulation of activated T cell proliferation (GO:0042104)2.89988802
166CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.86340531
167negative regulation of adaptive immune response (GO:0002820)2.86263974
168positive thymic T cell selection (GO:0045059)2.86006477
169positive regulation of myotube differentiation (GO:0010831)2.84616940
170negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.83370173
171negative regulation of cell killing (GO:0031342)2.83370173
172positive regulation of blood vessel endothelial cell migration (GO:0043536)2.83225587
173positive regulation of DNA recombination (GO:0045911)2.81718665
174regulation of hypersensitivity (GO:0002883)2.81706629
175tolerance induction (GO:0002507)2.81310956
176negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.80132155
177leukocyte aggregation (GO:0070486)2.79726356
178positive regulation of B cell differentiation (GO:0045579)2.77672873
179membrane protein intracellular domain proteolysis (GO:0031293)2.76636386
180regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)2.75808023
181regulation of T cell receptor signaling pathway (GO:0050856)2.74767864
182protein localization to cilium (GO:0061512)2.74118894
183T cell differentiation involved in immune response (GO:0002292)2.72083014
184alpha-beta T cell differentiation involved in immune response (GO:0002293)2.72083014
185alpha-beta T cell activation involved in immune response (GO:0002287)2.72083014
186alpha-beta T cell activation (GO:0046631)2.71479228
187myeloid dendritic cell activation (GO:0001773)2.69971902
188alpha-beta T cell differentiation (GO:0046632)2.69893355
189positive regulation of T cell mediated cytotoxicity (GO:0001916)2.69791851
190regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.68553590
191detection of chemical stimulus involved in sensory perception of smell (GO:0050911)12.6600066
192tooth mineralization (GO:0034505)12.3017627
193positive regulation of protein sumoylation (GO:0033235)10.5684665

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IGF1R_20145208_ChIP-Seq_DFB_Human5.23927696
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.07310702
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.03758242
4VDR_22108803_ChIP-Seq_LS180_Human5.02340432
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.79582625
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.77029221
7EGR1_19374776_ChIP-ChIP_THP-1_Human4.39186836
8AR_21572438_ChIP-Seq_LNCaP_Human4.09914738
9IRF8_21731497_ChIP-ChIP_J774_Mouse3.64847696
10RUNX_20019798_ChIP-Seq_JUKART_Human3.30656835
11IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.10671616
12* FLI1_27457419_Chip-Seq_LIVER_Mouse3.02124736
13SCL_19346495_ChIP-Seq_HPC-7_Human2.94524309
14* PCGF2_27294783_Chip-Seq_ESCs_Mouse2.93306569
15SMAD_19615063_ChIP-ChIP_OVARY_Human2.91890766
16* PCGF2_27294783_Chip-Seq_NPCs_Mouse2.82055725
17PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.66168425
18STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.66103425
19STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.61206061
20NOTCH1_21737748_ChIP-Seq_TLL_Human2.58472012
21IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.55410412
22* SUZ12_27294783_Chip-Seq_NPCs_Mouse2.29526889
23LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.21227007
24MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.20184134
25* NFE2_27457419_Chip-Seq_LIVER_Mouse2.15022531
26ZNF274_21170338_ChIP-Seq_K562_Hela2.08821237
27TP53_16413492_ChIP-PET_HCT116_Human1.98678099
28IRF8_22096565_ChIP-ChIP_GC-B_Human1.93847593
29IRF8_27001747_Chip-Seq_BMDM_Mouse1.85396234
30BP1_19119308_ChIP-ChIP_Hs578T_Human1.84944057
31GBX2_23144817_ChIP-Seq_PC3_Human1.84502818
32* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.82759003
33TCF4_18268006_ChIP-ChIP_LS174T_Human1.81785434
34CTBP1_25329375_ChIP-Seq_LNCAP_Human1.81426105
35PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.80532891
36GATA1_19941826_ChIP-Seq_K562_Human1.80369347
37AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.78351250
38* EZH2_27294783_Chip-Seq_NPCs_Mouse1.69149703
39SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.67468289
40* GATA2_21666600_ChIP-Seq_HMVEC_Human1.65815025
41* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.64792818
42YY1_22570637_ChIP-Seq_MALME-3M_Human1.63370227
43STAT4_19710469_ChIP-ChIP_TH1__Mouse1.62261803
44RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.61634043
45Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.61404486
46CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.59829041
47SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.59409609
48CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.58301093
49IKZF1_21737484_ChIP-ChIP_HCT116_Human1.58283776
50SMAD3_21741376_ChIP-Seq_EPCs_Human1.56987444
51LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.54270790
52MYB_26560356_Chip-Seq_TH1_Human1.54213970
53ER_23166858_ChIP-Seq_MCF-7_Human1.53363959
54RNF2_27304074_Chip-Seq_NSC_Mouse1.53037764
55NR3C1_23031785_ChIP-Seq_PC12_Mouse1.51877840
56RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.49075118
57SMAD3_21741376_ChIP-Seq_HESCs_Human1.47404360
58MYB_21317192_ChIP-Seq_ERMYB_Mouse1.46378663
59* CMYC_18555785_Chip-Seq_ESCs_Mouse1.44937319
60MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.42387775
61UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.41108157
62* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.39926188
63BCAT_22108803_ChIP-Seq_LS180_Human1.39322831
64* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.39171262
65* OCT4_18555785_Chip-Seq_ESCs_Mouse1.38153270
66RNF2_27304074_Chip-Seq_ESCs_Mouse1.37818021
67* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.36656952
68EZH2_27304074_Chip-Seq_ESCs_Mouse1.35294286
69DROSHA_22980978_ChIP-Seq_HELA_Human1.34534110
70* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.34017800
71MYB_26560356_Chip-Seq_TH2_Human1.33206005
72POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.32486308
73TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32486308
74SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.31847655
75* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.31415040
76* P53_22387025_ChIP-Seq_ESCs_Mouse1.31078525
77CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.30987270
78* NANOG_18555785_Chip-Seq_ESCs_Mouse1.30251378
79TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.30130991
80* STAT3_18555785_Chip-Seq_ESCs_Mouse1.29803078
81P300_19829295_ChIP-Seq_ESCs_Human1.29616833
82VDR_24787735_ChIP-Seq_THP-1_Human1.28715996
83* E2F1_18555785_Chip-Seq_ESCs_Mouse1.28283602
84GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.27857502
85* ESRRB_18555785_Chip-Seq_ESCs_Mouse1.27682326
86JARID2_20064375_ChIP-Seq_MESCs_Mouse1.27453051
87* OCT4_21477851_ChIP-Seq_ESCs_Mouse1.27140233
88NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.26615021
89* CTCF_18555785_Chip-Seq_ESCs_Mouse1.26383934
90KDM2B_26808549_Chip-Seq_REH_Human1.24793258
91SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.24698861
92PRDM14_20953172_ChIP-Seq_ESCs_Human1.24329680
93CTBP2_25329375_ChIP-Seq_LNCAP_Human1.23984504
94* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.23789925
95* PU1_27457419_Chip-Seq_LIVER_Mouse1.23176185
96* CRX_20693478_ChIP-Seq_RETINA_Mouse1.22708567
97* NMYC_18555785_Chip-Seq_ESCs_Mouse1.21098990
98TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.20782525
99CBX2_27304074_Chip-Seq_ESCs_Mouse1.19710913
100CBP_20019798_ChIP-Seq_JUKART_Human1.19329041
101IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.19329041
102* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.18393777
103EED_16625203_ChIP-ChIP_MESCs_Mouse1.17974618
104* ZFX_18555785_Chip-Seq_ESCs_Mouse1.17820384
105JARID2_20075857_ChIP-Seq_MESCs_Mouse1.17466821
106* RUNX1_27457419_Chip-Seq_LIVER_Mouse1.16801878
107MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.16295109
108CDX2_19796622_ChIP-Seq_MESCs_Mouse1.15724144
109* P300_18555785_Chip-Seq_ESCs_Mouse1.15717928
110SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.15280027
111POU3F2_20337985_ChIP-ChIP_501MEL_Human1.14008227
112SMAD4_21799915_ChIP-Seq_A2780_Human1.12296023
113AR_25329375_ChIP-Seq_VCAP_Human1.11453255
114HNFA_21074721_ChIP-Seq_CACO-2_Human1.11432750
115PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.10825445
116PIAS1_25552417_ChIP-Seq_VCAP_Human1.10756933
117NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.10521589
118SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.10349709
119TCF4_22108803_ChIP-Seq_LS180_Human1.09488661
120* SOX2_18555785_Chip-Seq_ESCs_Mouse1.08960972
121EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.08259310
122EGR1_19032775_ChIP-ChIP_M12_Human1.07985020
123* GATA3_27048872_Chip-Seq_THYMUS_Human1.07875979
124FUS_26573619_Chip-Seq_HEK293_Human1.07503802
125TBL1_22424771_ChIP-Seq_293T_Human1.06173193
126SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.05996352
127* SMAD1_18555785_Chip-Seq_ESCs_Mouse1.05898197
128SMAD4_21741376_ChIP-Seq_HESCs_Human1.04874704
129ETV2_25802403_ChIP-Seq_MESCs_Mouse1.04198402
130* KLF4_18555785_Chip-Seq_ESCs_Mouse1.03656374
131BMI1_23680149_ChIP-Seq_NPCS_Mouse1.02692099
132EZH2_22144423_ChIP-Seq_EOC_Human1.02301475
133EZH2_27294783_Chip-Seq_ESCs_Mouse1.01052384
134SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.00452819
135GATA6_21074721_ChIP-Seq_CACO-2_Human0.99513052
136MTF2_20144788_ChIP-Seq_MESCs_Mouse0.99457244
137PHF8_20622853_ChIP-Seq_HELA_Human0.99264771
138TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.99183971
139VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.98831758
140EGR1_23403033_ChIP-Seq_LIVER_Mouse0.98797922
141STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.98621871
142SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98016555
143MAF_26560356_Chip-Seq_TH1_Human0.97196520
144GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96013360
145SUZ12_27294783_Chip-Seq_ESCs_Mouse0.94734828
146PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.94474991
147SMAD4_21741376_ChIP-Seq_EPCs_Human0.94426433
148STAT3_23295773_ChIP-Seq_U87_Human0.94314514
149* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.94262140
150CJUN_26792858_Chip-Seq_BT549_Human0.93955814
151NR3C1_21868756_ChIP-Seq_MCF10A_Human0.93899459
152SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.93346539
153GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.92943506
154GATA3_26560356_Chip-Seq_TH2_Human0.92734769
155CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.90672897
156PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.90492921
157VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.90065709
158ARNT_22903824_ChIP-Seq_MCF-7_Human0.89921580
159SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.89708497
160EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.89485893
161SOX2_19829295_ChIP-Seq_ESCs_Human0.89404854
162NANOG_19829295_ChIP-Seq_ESCs_Human0.89404854
163ETV1_20927104_ChIP-Seq_GIST48_Human0.88791240
164NANOG_20526341_ChIP-Seq_ESCs_Human0.88660920
165ZNF217_24962896_ChIP-Seq_MCF-7_Human0.88407277
166REST_21632747_ChIP-Seq_MESCs_Mouse0.87696046
167TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.87345334
168TAL1_26923725_Chip-Seq_HPCs_Mouse0.87014135
169ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.86599651
170GATA1_22025678_ChIP-Seq_K562_Human0.86152238
171KLF5_20875108_ChIP-Seq_MESCs_Mouse0.85741241
172PU_27001747_Chip-Seq_BMDM_Mouse0.85702641
173RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.83386008
174GATA2_19941826_ChIP-Seq_K562_Human0.83162665

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008961_abnormal_basal_metabolism7.63850357
2MP0010368_abnormal_lymphatic_system4.56828636
3MP0006292_abnormal_olfactory_placode4.44981196
4MP0005671_abnormal_response_to3.69840534
5MP0005174_abnormal_tail_pigmentation3.30389192
6MP0003724_increased_susceptibility_to3.17349536
7MP0003763_abnormal_thymus_physiology3.16180743
8MP0004272_abnormal_basement_membrane3.04747021
9MP0001873_stomach_inflammation2.93714215
10MP0002396_abnormal_hematopoietic_system2.89727001
11MP0001188_hyperpigmentation2.83745325
12MP0001800_abnormal_humoral_immune2.77622205
13MP0001502_abnormal_circadian_rhythm2.66658529
14MP0004133_heterotaxia2.58792740
15MP0001879_abnormal_lymphatic_vessel2.55616795
16MP0003567_abnormal_fetal_cardiomyocyte2.44111442
17MP0006072_abnormal_retinal_apoptosis2.32282374
18MP0005000_abnormal_immune_tolerance2.28669805
19MP0005387_immune_system_phenotype2.25346339
20MP0001790_abnormal_immune_system2.25346339
21MP0009785_altered_susceptibility_to2.25139331
22MP0002452_abnormal_antigen_presenting2.23888654
23MP0001835_abnormal_antigen_presentation2.23446412
24MP0003943_abnormal_hepatobiliary_system2.22886660
25MP0009278_abnormal_bone_marrow2.20888824
26MP0002420_abnormal_adaptive_immunity2.19880207
27MP0001819_abnormal_immune_cell2.17638681
28MP0002723_abnormal_immune_serum2.17220757
29MP0006054_spinal_hemorrhage2.16088226
30MP0002148_abnormal_hypersensitivity_rea2.13916143
31MP0005025_abnormal_response_to2.10647285
32MP0005464_abnormal_platelet_physiology2.09570727
33MP0002398_abnormal_bone_marrow2.07107264
34MP0004264_abnormal_extraembryonic_tissu2.02887289
35MP0005084_abnormal_gallbladder_morpholo12.1146982
36MP0000685_abnormal_immune_system1.98895529
37MP0005397_hematopoietic_system_phenotyp1.94911565
38MP0001545_abnormal_hematopoietic_system1.94911565
39MP0005423_abnormal_somatic_nervous1.94665384
40MP0000465_gastrointestinal_hemorrhage1.93106664
41MP0002751_abnormal_autonomic_nervous1.92793968
42MP0003221_abnormal_cardiomyocyte_apopto1.91346884
43MP0005448_abnormal_energy_balance1.90788880
44MP0000716_abnormal_immune_system1.85527498
45MP0010155_abnormal_intestine_physiology1.82200686
46MP0002419_abnormal_innate_immunity1.74616098
47MP0005220_abnormal_exocrine_pancreas1.72689347
48MP0009764_decreased_sensitivity_to1.69373395
49MP0000703_abnormal_thymus_morphology1.67666811
50MP0001270_distended_abdomen1.63417231
51MP0006082_CNS_inflammation1.63240144
52MP0002138_abnormal_hepatobiliary_system1.57932140
53MP0003718_maternal_effect1.57390991
54MP0005167_abnormal_blood-brain_barrier1.56935654
55MP0005075_abnormal_melanosome_morpholog1.51719421
56MP0003941_abnormal_skin_development1.49586450
57MP0002429_abnormal_blood_cell1.48093682
58MP0003436_decreased_susceptibility_to1.47470959
59MP0003195_calcinosis1.46218179
60MP0005410_abnormal_fertilization1.45724727
61MP0001348_abnormal_lacrimal_gland1.43791037
62MP0003787_abnormal_imprinting1.42332192
63MP0005165_increased_susceptibility_to1.40665468
64MP0004947_skin_inflammation1.40513260
65MP0004484_altered_response_of1.39626441
66MP0002722_abnormal_immune_system1.38317714
67MP0004130_abnormal_muscle_cell1.36440941
68MP0003300_gastrointestinal_ulcer1.36151490
69MP0000566_synostosis1.35692901
70MP0001853_heart_inflammation1.35207992
71MP0000689_abnormal_spleen_morphology1.32414282
72MP0000343_altered_response_to1.31841631
73MP0002405_respiratory_system_inflammati1.29182195
74MP0002095_abnormal_skin_pigmentation1.28265432
75MP0003329_amyloid_beta_deposits1.25717080
76MP0005171_absent_coat_pigmentation1.23948715
77MP0005379_endocrine/exocrine_gland_phen1.22726336
78MP0003638_abnormal_response/metabolism_1.21763075
79MP0005646_abnormal_pituitary_gland1.21420805
80MP0001529_abnormal_vocalization1.16973310
81MP0001915_intracranial_hemorrhage1.15114884
82MP0001905_abnormal_dopamine_level1.14260331
83MP0005408_hypopigmentation1.13348833
84MP0009379_abnormal_foot_pigmentation1.11902602
85MP0001845_abnormal_inflammatory_respons1.04977450
86MP0004147_increased_porphyrin_level1.04132739
87MP0004808_abnormal_hematopoietic_stem1.02185518
88MP0008469_abnormal_protein_level0.97472155
89MP0000015_abnormal_ear_pigmentation0.93804498
90MP0009333_abnormal_splenocyte_physiolog0.91517887
91MP0008058_abnormal_DNA_repair0.89740616
92MP0001944_abnormal_pancreas_morphology0.89156518
93MP0003303_peritoneal_inflammation0.89126430
94MP0002572_abnormal_emotion/affect_behav0.88931111
95MP0002006_tumorigenesis0.88380804
96MP0005310_abnormal_salivary_gland0.87480536
97MP0003566_abnormal_cell_adhesion0.86335951
98MP0003252_abnormal_bile_duct0.86165925
99MP0003121_genomic_imprinting0.85151257
100MP0005253_abnormal_eye_physiology0.85038398
101MP0000579_abnormal_nail_morphology0.84742998
102MP0001663_abnormal_digestive_system0.83543762
103MP0002928_abnormal_bile_duct0.83479845
104MP0000490_abnormal_crypts_of0.83460175
105MP0001958_emphysema0.83171614
106MP0001533_abnormal_skeleton_physiology0.82842889
107MP0001501_abnormal_sleep_pattern0.82649880
108MP0005551_abnormal_eye_electrophysiolog0.79315523
109MP0003828_pulmonary_edema0.78822846
110MP0010094_abnormal_chromosome_stability0.76155219
111MP0003448_altered_tumor_morphology0.75911138
112MP0000470_abnormal_stomach_morphology0.75246468
113MP0004782_abnormal_surfactant_physiolog0.74922604
114MP0000604_amyloidosis0.74488909
115MP0009697_abnormal_copulation0.74375116
116MP0005365_abnormal_bile_salt0.73477223
117MP0002933_joint_inflammation0.72015388
118MP0004145_abnormal_muscle_electrophysio0.71535969
119MP0008877_abnormal_DNA_methylation0.71153828
120MP0008875_abnormal_xenobiotic_pharmacok0.69982924
121MP0008004_abnormal_stomach_pH0.69035656
122MP0006276_abnormal_autonomic_nervous0.68794051
123MP0002128_abnormal_blood_circulation0.68319257
124MP0009763_increased_sensitivity_to0.66963510
125MP0000858_altered_metastatic_potential0.65297215
126MP0005164_abnormal_response_to0.65082862
127MP0002060_abnormal_skin_morphology0.64953227
128MP0001986_abnormal_taste_sensitivity0.64392295
129MP0002277_abnormal_respiratory_mucosa0.64180523
130MP0001346_abnormal_lacrimal_gland0.64032790
131MP0002693_abnormal_pancreas_physiology0.63194150
132MP0000249_abnormal_blood_vessel0.62928653
133MP0004885_abnormal_endolymph0.62764933
134MP0004381_abnormal_hair_follicle0.62204357
135MP0003011_delayed_dark_adaptation0.61194423
136MP0002736_abnormal_nociception_after0.60055100
137MP0001968_abnormal_touch/_nociception0.59604793
138MP0002877_abnormal_melanocyte_morpholog0.58872639
139MP0005395_other_phenotype0.58565890
140MP0003698_abnormal_male_reproductive0.58559263
141MP0003806_abnormal_nucleotide_metabolis0.57556943
142MP0002735_abnormal_chemical_nociception0.56538293
143MP0001119_abnormal_female_reproductive0.56034336
144MP0003091_abnormal_cell_migration0.55108453
145MP0005595_abnormal_vascular_smooth0.54772114
146MP0000013_abnormal_adipose_tissue0.52789086
147MP0000371_diluted_coat_color0.52541571
148MP0002102_abnormal_ear_morphology0.50550422
149MP0008569_lethality_at_weaning0.49184840
150MP0001851_eye_inflammation0.47948931
151MP0002638_abnormal_pupillary_reflex0.47348682
152MP0001293_anophthalmia0.46589893
153MP0002332_abnormal_exercise_endurance0.46260269
154MP0000609_abnormal_liver_physiology0.45630683
155MP0000372_irregular_coat_pigmentation0.45442038
156MP0000598_abnormal_liver_morphology0.43955211
157MP0008775_abnormal_heart_ventricle0.43083121
158MP0002136_abnormal_kidney_physiology0.41229849
159MP0004019_abnormal_vitamin_homeostasis0.40343252
160MP0003866_abnormal_defecation0.40240044
161MP0003646_muscle_fatigue0.38412857
162MP0003953_abnormal_hormone_level0.38333845
163MP0005195_abnormal_posterior_eye0.37839666
164MP0000230_abnormal_systemic_arterial0.36682643
165MP0002078_abnormal_glucose_homeostasis0.36359267
166MP0003880_abnormal_central_pattern0.34547212
167MP0001614_abnormal_blood_vessel0.33746846
168MP0000767_abnormal_smooth_muscle0.33501921
169MP0009642_abnormal_blood_homeostasis0.33433642
170MP0005391_vision/eye_phenotype0.33125745
171MP0002295_abnormal_pulmonary_circulatio0.31678926
172MP0002909_abnormal_adrenal_gland0.30890214
173MP0002098_abnormal_vibrissa_morphology0.30598972
174MP0002822_catalepsy0.30347356
175MP0004085_abnormal_heartbeat0.30113702

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of calcium-phosphate metabolism (HP:0100530)8.29607064
2Abnormality of dental color (HP:0011073)7.68452597
3Abnormality of renal resorption (HP:0011038)7.16590918
4Polyuria (HP:0000103)7.06475205
5Osteomalacia (HP:0002749)6.82126817
6Hypoplasia of the thymus (HP:0000778)6.76333282
7Abnormality of the dental pulp (HP:0006479)6.22723797
8Abnormality of B cell number (HP:0010975)6.11054848
9B lymphocytopenia (HP:0010976)6.11054848
10Respiratory insufficiency due to defective ciliary clearance (HP:0200073)6.08500263
11Abnormal urine output (HP:0012590)6.01553267
12Abnormality of renal excretion (HP:0011036)5.21793224
13Panhypogammaglobulinemia (HP:0003139)5.21634134
14Severe combined immunodeficiency (HP:0004430)5.05180035
15Optic neuritis (HP:0100653)4.87703725
16Retrobulbar optic neuritis (HP:0100654)4.87703725
17Osteolytic defects of the phalanges of the hand (HP:0009771)4.77088403
18Osteolytic defects of the hand bones (HP:0009699)4.77088403
19Thyroiditis (HP:0100646)4.67591851
20Abnormality of midbrain morphology (HP:0002418)4.59319108
21Molar tooth sign on MRI (HP:0002419)4.59319108
22Esophageal varix (HP:0002040)4.57528889
23Autoamputation (HP:0001218)4.48445121
24Renal cortical cysts (HP:0000803)4.41782595
25Round ear (HP:0100830)4.29277391
26Myositis (HP:0100614)4.25358870
27Combined immunodeficiency (HP:0005387)4.22139209
28Chronic bronchitis (HP:0004469)4.19013653
29Orchitis (HP:0100796)4.12610252
30Autoimmune thrombocytopenia (HP:0001973)3.95618179
31Eosinophilia (HP:0001880)3.92005471
32Abnormality of eosinophils (HP:0001879)3.90639164
33Nephronophthisis (HP:0000090)3.60811653
34Recurrent fungal infections (HP:0002841)3.60451630
35Leukocytosis (HP:0001974)3.43442629
36Generalized aminoaciduria (HP:0002909)3.42344932
37Elevated erythrocyte sedimentation rate (HP:0003565)3.33589745
38Tachypnea (HP:0002789)3.29627382
39Toxemia of pregnancy (HP:0100603)3.28174393
40Abnormal respiratory motile cilium physiology (HP:0012261)3.24759235
41Hypoglycemic coma (HP:0001325)3.20608112
42Petechiae (HP:0000967)3.19400261
43Hypoproteinemia (HP:0003075)3.13944011
44Nephrocalcinosis (HP:0000121)3.09657860
45Drooling (HP:0002307)3.08253131
46Premature loss of primary teeth (HP:0006323)3.07204160
47White forelock (HP:0002211)3.04240594
48Keratoconjunctivitis sicca (HP:0001097)3.04078422
49Granulocytopenia (HP:0001913)3.00556577
50Recurrent viral infections (HP:0004429)2.97928639
51Rhinitis (HP:0012384)2.92075902
52Stomatitis (HP:0010280)2.89756774
53Excessive salivation (HP:0003781)2.88073321
54Patchy hypopigmentation of hair (HP:0011365)2.86252804
55Eczematoid dermatitis (HP:0000976)2.81658665
56Chronic diarrhea (HP:0002028)2.81005743
57Abnormality of the renal medulla (HP:0100957)2.79542041
58Increased IgM level (HP:0003496)2.78191671
59Lipoatrophy (HP:0100578)2.76029154
60Keratoconjunctivitis (HP:0001096)2.74155972
61Pulmonary infiltrates (HP:0002113)2.73017510
62Inability to walk (HP:0002540)2.69232428
63Adactyly (HP:0009776)2.65067581
64Depressed nasal tip (HP:0000437)2.61871801
65Lip pit (HP:0100267)2.60564396
66Recurrent bacterial skin infections (HP:0005406)2.59095254
67T lymphocytopenia (HP:0005403)2.59036817
68Gingival bleeding (HP:0000225)2.57971264
69Osteomyelitis (HP:0002754)2.54954860
70Absent frontal sinuses (HP:0002688)2.53584277
71Abnormality of T cell number (HP:0011839)2.52637418
72Hyperphosphaturia (HP:0003109)2.52193336
73Arterial thrombosis (HP:0004420)2.51386322
74Abnormality of the axillary hair (HP:0100134)2.49353308
75Abnormality of secondary sexual hair (HP:0009888)2.49353308
76Abnormality of the renal cortex (HP:0011035)2.48576732
77Vertigo (HP:0002321)2.48496217
78Large earlobe (HP:0009748)2.47142853
79Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.46525418
80Recurrent abscess formation (HP:0002722)2.44549652
81Thick eyebrow (HP:0000574)2.43259016
82Hypoparathyroidism (HP:0000829)2.43121788
83Severe visual impairment (HP:0001141)2.42785109
84Prolonged bleeding time (HP:0003010)2.42102049
85Decreased muscle mass (HP:0003199)2.39210204
86Pancytopenia (HP:0001876)2.38332777
87Encephalitis (HP:0002383)2.37969008
88Abnormality of transition element cation homeostasis (HP:0011030)2.37123269
89Glycosuria (HP:0003076)2.35496868
90Abnormality of urine glucose concentration (HP:0011016)2.35496868
91IgM deficiency (HP:0002850)2.35249867
92Vasculitis (HP:0002633)2.33395106
93Recurrent bronchitis (HP:0002837)2.32176162
94Abnormal delayed hypersensitivity skin test (HP:0002963)2.31252843
95Dynein arm defect of respiratory motile cilia (HP:0012255)2.30893927
96Absent/shortened dynein arms (HP:0200106)2.30893927
97Hypochromic microcytic anemia (HP:0004840)2.29190825
98Ectopic kidney (HP:0000086)2.25767694
99Erythroderma (HP:0001019)2.25717944
100Chronic otitis media (HP:0000389)2.23446721
101Recurrent sinusitis (HP:0011108)2.22706267
102Nausea (HP:0002018)2.21207427
103Nephropathy (HP:0000112)2.21108072
104Intestinal fistula (HP:0100819)2.18684062
105Spontaneous hematomas (HP:0007420)2.17189840
106Abnormality of the frontal sinuses (HP:0002687)2.12799870
107Congenital stationary night blindness (HP:0007642)2.10739473
108Chromsome breakage (HP:0040012)2.09558090
109Bruising susceptibility (HP:0000978)2.09484848
110Neonatal death (HP:0003811)2.07447834
111Hepatitis (HP:0012115)2.07372022
112Abnormality of T cells (HP:0002843)2.06062693
113Personality changes (HP:0000751)2.05174516
114IgA deficiency (HP:0002720)2.03208933
115Chronic mucocutaneous candidiasis (HP:0002728)2.02420804
116Recurrent cutaneous fungal infections (HP:0011370)2.02420804
117Dilated cardiomyopathy (HP:0001644)2.01185293
118Aplasia cutis congenita (HP:0001057)2.00887194
119Proximal tubulopathy (HP:0000114)2.00152949
120Overgrowth (HP:0001548)10.5796091
121Amelogenesis imperfecta (HP:0000705)10.1444178
122Pallor (HP:0000980)1.98186097
123Prominent supraorbital ridges (HP:0000336)1.98112549
124Abnormal urine phosphate concentration (HP:0012599)1.95975109
125Epistaxis (HP:0000421)1.94431461
126Gingival overgrowth (HP:0000212)1.94088850
127Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.92000950
128Stage 5 chronic kidney disease (HP:0003774)1.91872032
129Small hand (HP:0200055)1.91589347
130Volvulus (HP:0002580)1.90942156
131Hematochezia (HP:0002573)1.90850009
132Joint swelling (HP:0001386)1.89267626
133Abnormality of salivation (HP:0100755)1.87883306
134Oculomotor apraxia (HP:0000657)1.87316149
135Meningitis (HP:0001287)1.86218219
136Hemoptysis (HP:0002105)1.86088525
137Chorioretinal coloboma (HP:0000567)1.85366924
138Acute myeloid leukemia (HP:0004808)1.83985927
139Thrombocytosis (HP:0001894)1.82689949
140Striae distensae (HP:0001065)1.82018809
141Abnormality of the prostate (HP:0008775)1.81242167
142Portal hypertension (HP:0001409)1.81196997
143Recurrent skin infections (HP:0001581)1.81118155
144Short 5th finger (HP:0009237)1.80787881
145Agammaglobulinemia (HP:0004432)1.80641334
146Abnormal respiratory epithelium morphology (HP:0012253)1.80116316
147Abnormal respiratory motile cilium morphology (HP:0005938)1.80116316
148Birth length less than 3rd percentile (HP:0003561)1.79796752
149Overlapping toe (HP:0001845)1.79644432
150Myelodysplasia (HP:0002863)1.78448489
151Reticulocytopenia (HP:0001896)1.77255152
152Tapered finger (HP:0001182)1.75063580
153Neonatal respiratory distress (HP:0002643)1.74971725
154Menorrhagia (HP:0000132)1.73723609
155Peritonitis (HP:0002586)1.73048800
156Abnormal hemoglobin (HP:0011902)1.71372620
157Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.71217116
158Abnormality of the hepatic vasculature (HP:0006707)1.70904711
159Broad alveolar ridges (HP:0000187)1.69455580
160Lymphoma (HP:0002665)1.69254289
161Porencephaly (HP:0002132)1.68070338
162Mediastinal lymphadenopathy (HP:0100721)1.66311961
163Recurrent pneumonia (HP:0006532)1.66190818
164IgG deficiency (HP:0004315)1.66061057
165Glucose intolerance (HP:0000833)1.65506771
166Limb dystonia (HP:0002451)1.64858193
167Polycythemia (HP:0001901)1.64239446
168Urticaria (HP:0001025)1.63816440
169Scotoma (HP:0000575)1.63753786
170Sudden cardiac death (HP:0001645)1.63699408
171Clubbing of toes (HP:0100760)1.63490204
172Abnormal rod and cone electroretinograms (HP:0008323)1.62771253
173Ectropion (HP:0000656)1.62559121
174Nonimmune hydrops fetalis (HP:0001790)1.62057719
175Cutis marmorata (HP:0000965)1.61551891
176Ureteral stenosis (HP:0000071)1.60310568
177Highly arched eyebrow (HP:0002553)1.59044586
178Sparse lateral eyebrow (HP:0005338)1.58957071
179Renal tubular dysfunction (HP:0000124)1.55982802
180Ureteral obstruction (HP:0006000)1.55770920
181Abnormality of the heme biosynthetic pathway (HP:0010472)1.55726434
182Bronchitis (HP:0012387)1.55472344
183Skull defect (HP:0001362)1.52982186
184Hypercalciuria (HP:0002150)1.52244873
185Hemiplegia (HP:0002301)1.48261102
186Widely spaced teeth (HP:0000687)1.47124849
187Colitis (HP:0002583)1.46873234
188Abolished electroretinogram (ERG) (HP:0000550)1.46321423
189Attenuation of retinal blood vessels (HP:0007843)1.44783542
190Chondrocalcinosis (HP:0000934)1.40891758
191Decreased central vision (HP:0007663)1.40283694
192Abnormality of Sharpey fibers (HP:0100685)1.39841780
193Delayed eruption of teeth (HP:0000684)1.36532952
194Impaired platelet aggregation (HP:0003540)1.34038065
195Abnormal platelet function (HP:0011869)1.34038065

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K66.98021103
2MAP2K35.34929475
3MAP4K15.16231943
4TXK4.58030236
5ZAP703.87811735
6MAP2K63.25659388
7MAP2K42.99339787
8MAP3K122.69351342
9BLK2.35243993
10PLK42.11005173
11TIE11.97789584
12MAP3K111.73304409
13BTK1.66363450
14JAK31.62326052
15MAP4K21.56830124
16STK241.54492425
17MAP3K51.47530705
18LCK1.35182620
19IRAK31.31429362
20MAP3K141.30261287
21FRK1.29390459
22RET1.23615214
23ITK1.23213788
24BMPR1B1.20348774
25KIT1.17114582
26CDC42BPA1.15597716
27WNK31.11091127
28TEC1.10609562
29LYN1.04990298
30MYLK0.98802699
31PRKD20.98229092
32IKBKE0.95754709
33PRKCH0.95067686
34HCK0.91920390
35MAP2K70.91209691
36INSRR0.91197297
37ACVR1B0.91103919
38CLK10.91103501
39EPHB20.89622893
40SYK0.83891288
41FGFR10.83329631
42TNK20.82830057
43STK100.78974618
44MATK0.78110338
45STK30.77574383
46MAP3K10.76509340
47AKT30.73746695
48TGFBR10.72972247
49TYK20.71212986
50PKN20.69304057
51MAPK130.69193397
52TBK10.68206491
53NUAK10.67556866
54PINK10.67173722
55ADRBK10.65652621
56CHUK0.63955841
57RIPK10.61924866
58PAK40.58698667
59RIPK40.58483755
60NTRK30.57848724
61SRC0.57652681
62MINK10.57546275
63NTRK20.56761004
64CDK120.56398131
65IKBKB0.56235502
66CSF1R0.55629329
67CDK70.55449100
68PTK2B0.55221002
69OXSR10.52861256
70TAOK30.52670311
71BRSK20.52413647
72TGFBR20.52003623
73CDK80.51492879
74CSNK1A1L0.51366954
75GRK10.51208599
76TLK10.50971384
77MAPK150.49039598
78KDR0.48986207
79IGF1R0.48162599
80TNIK0.47258502
81JAK10.47239796
82PLK20.46980596
83ROCK20.46565273
84EEF2K0.46081220
85FGFR40.45898888
86CSK0.45673745
87PRKAA10.45656129
88EPHA30.45655023
89FLT30.45561311
90HIPK20.45388402
91PRKCQ0.44802753
92FES0.44572806
93SRPK10.43870768
94CCNB10.43332725
95PASK0.43216004
96ABL10.42185093
97ROCK10.41735434
98ADRBK20.41138674
99ATR0.39591118
100PIK3CG0.39540868
101BCKDK0.38959062
102OBSCN0.37694316
103TTK0.35701957
104JAK20.35677485
105MAPKAPK50.35059747
106PDK40.35013204
107PDK30.35013204
108NLK0.34972796
109ZAK0.34850826
110PRKACA0.34415734
111PDK20.33889588
112RPS6KB20.33814988
113VRK10.33449084
114MUSK0.33329674
115PKN10.32953644
116TSSK60.32832308
117PRKACG0.31322144
118TRPM70.30575284
119PRKCE0.30417338
120WNK40.30224964
121PLK10.29971498
122FER0.29704632
123SIK30.29667378
124PIM20.29104983
125CDK60.28257202
126STK390.28045377
127PRKACB0.27535793
128PRKG20.27016403
129DAPK10.26860292
130GRK50.25465307
131CAMK2A0.24771425
132PRKCA0.24688552
133EGFR0.24646244
134EIF2AK20.24567987
135MAPKAPK30.23456889
136MAP3K40.23450096
137FYN0.22554515
138MAP3K130.22301080
139WEE10.21764157
140RPS6KB10.21544946
141WNK10.20557286
142PDK10.19868290
143CSNK1A10.17818003
144PRKCG0.17797118
145SGK20.16250661
146RPS6KA50.16202109
147ERBB40.15793739
148ATM0.14985095
149BMPR20.14732196
150PHKG10.14314492
151PHKG20.14314492
152PRKCB0.13988802
153CSNK1G10.13594800
154NTRK10.13473450
155ERBB30.13195220
156DAPK20.11718420
157ABL20.11406477
158INSR0.11186211
159PRKCD0.09570250
160MAPK90.09445944
161CDK30.09371251
162RPS6KA30.08934201
163MAPK140.08929496

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047405.28497218
2Primary immunodeficiency_Homo sapiens_hsa053404.08341313
3Inflammatory bowel disease (IBD)_Homo sapiens_hsa053213.67655270
4Sulfur metabolism_Homo sapiens_hsa009203.58897382
5Non-homologous end-joining_Homo sapiens_hsa034503.57494117
6Sulfur relay system_Homo sapiens_hsa041223.26216189
7Allograft rejection_Homo sapiens_hsa053302.99610159
8NF-kappa B signaling pathway_Homo sapiens_hsa040642.64585751
9Intestinal immune network for IgA production_Homo sapiens_hsa046722.64275092
10Leishmaniasis_Homo sapiens_hsa051402.60686030
11Regulation of lipolysis in adipocytes_Homo sapiens_hsa049232.57113506
12Hematopoietic cell lineage_Homo sapiens_hsa046402.55341326
13T cell receptor signaling pathway_Homo sapiens_hsa046602.54513929
14RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.53122662
15Longevity regulating pathway - multiple species_Homo sapiens_hsa042132.42529260
16NOD-like receptor signaling pathway_Homo sapiens_hsa046212.42070725
17Collecting duct acid secretion_Homo sapiens_hsa049662.37889843
18Salivary secretion_Homo sapiens_hsa049702.15269905
19Autoimmune thyroid disease_Homo sapiens_hsa053202.11534885
20Osteoclast differentiation_Homo sapiens_hsa043802.07471306
21Bile secretion_Homo sapiens_hsa049762.06540917
22Pancreatic secretion_Homo sapiens_hsa049722.04170332
23Measles_Homo sapiens_hsa051622.03929687
24Fat digestion and absorption_Homo sapiens_hsa049752.03743523
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.95906941
26Thyroid hormone synthesis_Homo sapiens_hsa049181.93442190
27Morphine addiction_Homo sapiens_hsa050321.85658590
28Circadian entrainment_Homo sapiens_hsa047131.85614873
29Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.85550180
30Gastric acid secretion_Homo sapiens_hsa049711.83829159
31Vibrio cholerae infection_Homo sapiens_hsa051101.83000811
32Vascular smooth muscle contraction_Homo sapiens_hsa042701.80963051
33Glutamatergic synapse_Homo sapiens_hsa047241.76137927
34GABAergic synapse_Homo sapiens_hsa047271.74134655
35Insulin secretion_Homo sapiens_hsa049111.73946703
36Cocaine addiction_Homo sapiens_hsa050301.73760684
37Toll-like receptor signaling pathway_Homo sapiens_hsa046201.70982806
38Asthma_Homo sapiens_hsa053101.70240644
39Synaptic vesicle cycle_Homo sapiens_hsa047211.66856265
40Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.66632190
41TNF signaling pathway_Homo sapiens_hsa046681.63604150
42Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.58503631
43Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.56947033
44B cell receptor signaling pathway_Homo sapiens_hsa046621.56128306
45Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.56035966
46Aldosterone synthesis and secretion_Homo sapiens_hsa049251.55396969
47Viral myocarditis_Homo sapiens_hsa054161.54649909
48Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.53196590
49Graft-versus-host disease_Homo sapiens_hsa053321.51871110
50Dilated cardiomyopathy_Homo sapiens_hsa054141.49789717
51Legionellosis_Homo sapiens_hsa051341.45943574
52Toxoplasmosis_Homo sapiens_hsa051451.45683649
53Arachidonic acid metabolism_Homo sapiens_hsa005901.43160805
54Jak-STAT signaling pathway_Homo sapiens_hsa046301.40068082
55Gap junction_Homo sapiens_hsa045401.37395053
56Longevity regulating pathway - mammal_Homo sapiens_hsa042111.33866652
57Malaria_Homo sapiens_hsa051441.31653656
58Transcriptional misregulation in cancer_Homo sapiens_hsa052021.26582353
59Amphetamine addiction_Homo sapiens_hsa050311.17701059
60Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.16718077
61Oxytocin signaling pathway_Homo sapiens_hsa049211.14919396
62Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.10546079
63African trypanosomiasis_Homo sapiens_hsa051431.08626674
64Calcium signaling pathway_Homo sapiens_hsa040201.06258834
65Type I diabetes mellitus_Homo sapiens_hsa049401.05832686
66Melanogenesis_Homo sapiens_hsa049161.03362007
67Serotonergic synapse_Homo sapiens_hsa047261.02404971
68Pertussis_Homo sapiens_hsa051331.01551385
69Shigellosis_Homo sapiens_hsa051311.00038512
70Prolactin signaling pathway_Homo sapiens_hsa049170.97440896
71Fatty acid degradation_Homo sapiens_hsa000710.95661748
72AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.95308334
73Cholinergic synapse_Homo sapiens_hsa047250.95295338
74Influenza A_Homo sapiens_hsa051640.94591650
75ECM-receptor interaction_Homo sapiens_hsa045120.92907359
76Herpes simplex infection_Homo sapiens_hsa051680.90375756
77Platelet activation_Homo sapiens_hsa046110.88586684
78Leukocyte transendothelial migration_Homo sapiens_hsa046700.88014467
79Hepatitis B_Homo sapiens_hsa051610.87014818
80Homologous recombination_Homo sapiens_hsa034400.82884469
81Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.82218054
82Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.79130861
83Estrogen signaling pathway_Homo sapiens_hsa049150.78034290
84Chemokine signaling pathway_Homo sapiens_hsa040620.77167358
85RNA degradation_Homo sapiens_hsa030180.75909716
86Tuberculosis_Homo sapiens_hsa051520.73520132
87Staphylococcus aureus infection_Homo sapiens_hsa051500.73255874
88Histidine metabolism_Homo sapiens_hsa003400.72350130
89Salmonella infection_Homo sapiens_hsa051320.72004990
90beta-Alanine metabolism_Homo sapiens_hsa004100.70970267
91Hepatitis C_Homo sapiens_hsa051600.70513018
92Rap1 signaling pathway_Homo sapiens_hsa040150.68401618
93Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.68222109
94MAPK signaling pathway_Homo sapiens_hsa040100.67792554
95Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.66814040
96Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.66771652
97Thyroid hormone signaling pathway_Homo sapiens_hsa049190.65493139
98Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.64908560
99Oocyte meiosis_Homo sapiens_hsa041140.64181117
100Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.61455230
101Phototransduction_Homo sapiens_hsa047440.60566561
102Pyruvate metabolism_Homo sapiens_hsa006200.58810469
103Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.53414530
104Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.51362224
105VEGF signaling pathway_Homo sapiens_hsa043700.51230657
106Parkinsons disease_Homo sapiens_hsa050120.50980481
107Apoptosis_Homo sapiens_hsa042100.50465296
108Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.48820231
109Neurotrophin signaling pathway_Homo sapiens_hsa047220.48729634
110Ovarian steroidogenesis_Homo sapiens_hsa049130.48424117
111Maturity onset diabetes of the young_Homo sapiens_hsa049500.48275532
112cAMP signaling pathway_Homo sapiens_hsa040240.48243073
113Peroxisome_Homo sapiens_hsa041460.47900242
114Circadian rhythm_Homo sapiens_hsa047100.47469731
115Nitrogen metabolism_Homo sapiens_hsa009100.46571044
116Rheumatoid arthritis_Homo sapiens_hsa053230.46094357
117Glycerophospholipid metabolism_Homo sapiens_hsa005640.45683719
118Epstein-Barr virus infection_Homo sapiens_hsa051690.45419033
119Purine metabolism_Homo sapiens_hsa002300.45314104
120Acute myeloid leukemia_Homo sapiens_hsa052210.45077929
121Caffeine metabolism_Homo sapiens_hsa002320.42971043
122Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.42713647
123Amoebiasis_Homo sapiens_hsa051460.41578584
124MicroRNAs in cancer_Homo sapiens_hsa052060.41539300
125Phospholipase D signaling pathway_Homo sapiens_hsa040720.41494215
126alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.41156616
127Insulin resistance_Homo sapiens_hsa049310.39759998
128Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.39445321
129Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.38489818
130p53 signaling pathway_Homo sapiens_hsa041150.37925000
131Dopaminergic synapse_Homo sapiens_hsa047280.37599014
132HTLV-I infection_Homo sapiens_hsa051660.37259273
133Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.37149886
134Notch signaling pathway_Homo sapiens_hsa043300.36005292
135Vitamin B6 metabolism_Homo sapiens_hsa007500.35580964
136ABC transporters_Homo sapiens_hsa020100.35057237
137Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.34717514
138Adipocytokine signaling pathway_Homo sapiens_hsa049200.33666718
139Steroid hormone biosynthesis_Homo sapiens_hsa001400.33325599
140Cysteine and methionine metabolism_Homo sapiens_hsa002700.32628022
141Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.32502161
142Linoleic acid metabolism_Homo sapiens_hsa005910.31975931
143cGMP-PKG signaling pathway_Homo sapiens_hsa040220.30309273
144Oxidative phosphorylation_Homo sapiens_hsa001900.30154134
145GnRH signaling pathway_Homo sapiens_hsa049120.30111222
146Alcoholism_Homo sapiens_hsa050340.29900175
147Dorso-ventral axis formation_Homo sapiens_hsa043200.29336247
148Ras signaling pathway_Homo sapiens_hsa040140.28010594
149FoxO signaling pathway_Homo sapiens_hsa040680.27857064
150mRNA surveillance pathway_Homo sapiens_hsa030150.27423958
151Nicotine addiction_Homo sapiens_hsa050330.26769659
152Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.26552669
153Vitamin digestion and absorption_Homo sapiens_hsa049770.26549807
154Chronic myeloid leukemia_Homo sapiens_hsa052200.25116023
155Taste transduction_Homo sapiens_hsa047420.24720886
156Other glycan degradation_Homo sapiens_hsa005110.24204478
157Ether lipid metabolism_Homo sapiens_hsa005650.22665246
158Retinol metabolism_Homo sapiens_hsa008300.21859631
159Sphingolipid signaling pathway_Homo sapiens_hsa040710.21392618
160Small cell lung cancer_Homo sapiens_hsa052220.20885975
161Renin secretion_Homo sapiens_hsa049240.19815178
162Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.17748865
163Chemical carcinogenesis_Homo sapiens_hsa052040.15089963
164SNARE interactions in vesicular transport_Homo sapiens_hsa041300.14531642
165Systemic lupus erythematosus_Homo sapiens_hsa053220.09484391

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