FAM126A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene may play a part in the beta-catenin/Lef signaling pathway. Expression of this gene is down-regulated by beta-catenin. Defects in this gene are a cause of hypomyelination with congenital cataract (HCC). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of gene silencing by RNA (GO:0060966)4.47518435
2regulation of posttranscriptional gene silencing (GO:0060147)4.47518435
3regulation of gene silencing by miRNA (GO:0060964)4.47518435
4protein localization to kinetochore (GO:0034501)3.98028665
5protoporphyrinogen IX metabolic process (GO:0046501)3.85698972
6mitotic metaphase plate congression (GO:0007080)3.80947463
7anterior/posterior axis specification, embryo (GO:0008595)3.74564268
8chromatin remodeling at centromere (GO:0031055)3.72317906
9cilium or flagellum-dependent cell motility (GO:0001539)3.70993752
10CENP-A containing nucleosome assembly (GO:0034080)3.70325092
11regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.67908918
12growth hormone receptor signaling pathway (GO:0060396)3.66899797
13cellular response to growth hormone stimulus (GO:0071378)3.57342084
14positive regulation of SMAD protein import into nucleus (GO:0060391)3.57247208
15atrial septum morphogenesis (GO:0060413)3.56926936
16negative regulation of DNA-dependent DNA replication (GO:2000104)3.55493074
17regulation of DNA endoreduplication (GO:0032875)3.52604371
18metaphase plate congression (GO:0051310)3.50345274
19cardiac myofibril assembly (GO:0055003)3.44582243
20histone exchange (GO:0043486)3.44514554
21protoporphyrinogen IX biosynthetic process (GO:0006782)3.41327771
22protein localization to chromosome, centromeric region (GO:0071459)3.39480707
23cytoplasmic mRNA processing body assembly (GO:0033962)3.36935087
24sister chromatid segregation (GO:0000819)3.35034803
25spindle checkpoint (GO:0031577)3.32392634
26paraxial mesoderm development (GO:0048339)3.31932954
27regulation of centriole replication (GO:0046599)3.28570868
28mitotic sister chromatid segregation (GO:0000070)3.23823879
29response to X-ray (GO:0010165)3.19728256
30nuclear pore complex assembly (GO:0051292)3.12847658
31ventricular cardiac muscle cell development (GO:0055015)3.11645006
32mitotic spindle checkpoint (GO:0071174)3.10879292
33establishment of chromosome localization (GO:0051303)3.07209012
34germ cell migration (GO:0008354)3.05855956
35negative regulation of mitotic sister chromatid separation (GO:2000816)3.05724779
36negative regulation of sister chromatid segregation (GO:0033046)3.05724779
37negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.05724779
38negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.05724779
39negative regulation of mitotic sister chromatid segregation (GO:0033048)3.05724779
40regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.03098862
41cellular response to interferon-alpha (GO:0035457)3.03025216
42negative regulation of fibroblast apoptotic process (GO:2000270)3.02860693
43negative regulation of chromosome segregation (GO:0051985)3.01760047
44gonadal mesoderm development (GO:0007506)3.00495802
45regulation of mitotic spindle checkpoint (GO:1903504)2.98929369
46regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.98929369
47positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.97387933
48cell migration involved in sprouting angiogenesis (GO:0002042)2.96641612
49regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.96296534
50regulation of mitotic metaphase/anaphase transition (GO:0030071)2.96296534
51replication fork processing (GO:0031297)2.93888943
52erythrocyte maturation (GO:0043249)2.93070092
53negative regulation of fatty acid transport (GO:2000192)2.90448773
54metanephric mesenchyme development (GO:0072075)2.87223033
55regulation of sister chromatid segregation (GO:0033045)2.86506826
56regulation of mitotic sister chromatid separation (GO:0010965)2.86506826
57regulation of mitotic sister chromatid segregation (GO:0033047)2.86506826
58negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.86120088
59negative regulation of translation, ncRNA-mediated (GO:0040033)2.86120088
60regulation of translation, ncRNA-mediated (GO:0045974)2.86120088
61mesenchymal-epithelial cell signaling (GO:0060638)2.85655517
62mitotic sister chromatid cohesion (GO:0007064)2.85261103
63regulation of chromosome segregation (GO:0051983)2.85210102
64protein heterotrimerization (GO:0070208)2.84781363
65lymphangiogenesis (GO:0001946)2.84084396
66DNA double-strand break processing (GO:0000729)2.83368064
67pre-miRNA processing (GO:0031054)2.81677449
68DNA replication checkpoint (GO:0000076)2.80871884
69establishment of integrated proviral latency (GO:0075713)2.80282353
70UDP-N-acetylglucosamine metabolic process (GO:0006047)2.79246992
71retina vasculature morphogenesis in camera-type eye (GO:0061299)2.79145043
72neuron projection extension involved in neuron projection guidance (GO:1902284)2.79122608
73axon extension involved in axon guidance (GO:0048846)2.79122608
74DNA replication-independent nucleosome assembly (GO:0006336)2.78165568
75DNA replication-independent nucleosome organization (GO:0034724)2.78165568
76telomere maintenance via telomerase (GO:0007004)2.76530611
77mitotic spindle assembly checkpoint (GO:0007094)2.76225789
78somatic hypermutation of immunoglobulin genes (GO:0016446)2.76220485
79somatic diversification of immune receptors via somatic mutation (GO:0002566)2.76220485
80cell fate commitment involved in formation of primary germ layer (GO:0060795)2.75891405
81regulation of hippo signaling (GO:0035330)2.75747235
82mitotic G2/M transition checkpoint (GO:0044818)2.75532359
83regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.74563680
84regulation of mesoderm development (GO:2000380)2.73815428
85regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.73365053
86spindle assembly checkpoint (GO:0071173)2.73124031
87female gonad development (GO:0008585)2.71304215
88myofibril assembly (GO:0030239)2.70983378
89notochord development (GO:0030903)2.68292763
90dorsal/ventral axis specification (GO:0009950)2.67781008
91hemoglobin metabolic process (GO:0020027)2.67160190
92positive regulation of natural killer cell differentiation (GO:0032825)2.66745214
93regulation of nuclear cell cycle DNA replication (GO:0033262)2.64529473
94estrogen biosynthetic process (GO:0006703)2.64211042
95histone H3-K36 demethylation (GO:0070544)2.64013214
96attachment of spindle microtubules to kinetochore (GO:0008608)2.63760912
97acrosome assembly (GO:0001675)2.63140799
98definitive hemopoiesis (GO:0060216)2.62901456
99erythrocyte development (GO:0048821)2.62807426
100RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.62238201
101kinetochore organization (GO:0051383)2.62154234
102artery development (GO:0060840)2.61467661
103DNA replication-dependent nucleosome organization (GO:0034723)2.59989761
104DNA replication-dependent nucleosome assembly (GO:0006335)2.59989761
105double-strand break repair via nonhomologous end joining (GO:0006303)2.59320716
106non-recombinational repair (GO:0000726)2.59320716
107somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.59270561
108somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.59270561
109isotype switching (GO:0045190)2.59270561
110NLS-bearing protein import into nucleus (GO:0006607)2.58635365
111negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)2.58375711
112IMP biosynthetic process (GO:0006188)2.58118895
113regulation of SMAD protein import into nucleus (GO:0060390)2.57442215
114negative regulation of DNA repair (GO:0045738)2.57320155
115pore complex assembly (GO:0046931)2.56558570
116mitotic cytokinesis (GO:0000281)2.55267462
117regulation of centrosome cycle (GO:0046605)2.55049705
118hippo signaling (GO:0035329)2.53927967
119collagen fibril organization (GO:0030199)2.53925720
120regulation of cell fate specification (GO:0042659)2.53644132
121negative chemotaxis (GO:0050919)2.53566863
122cellular response to zinc ion (GO:0071294)2.51251711
123IMP metabolic process (GO:0046040)2.50771088
124embryonic hemopoiesis (GO:0035162)2.49404654
125sequestering of extracellular ligand from receptor (GO:0035581)2.49085646
126piRNA metabolic process (GO:0034587)2.48678632
127kidney mesenchyme development (GO:0072074)2.48174860
128regulation of interleukin-12 biosynthetic process (GO:0045075)2.46799549
129cell adhesion mediated by integrin (GO:0033627)2.44837191
130positive regulation of macrophage cytokine production (GO:0060907)2.44561390
131negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.41866503
132epithelial cilium movement (GO:0003351)2.41479211
133erythrocyte differentiation (GO:0030218)2.41297294
134cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.40256022
135cilium movement (GO:0003341)2.38055611
136antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.36742441
137lymph vessel development (GO:0001945)2.36659110
138regulation of RNA export from nucleus (GO:0046831)2.36215337
139positive regulation of erythrocyte differentiation (GO:0045648)2.35319046
140porphyrin-containing compound biosynthetic process (GO:0006779)2.35204710
141positive regulation of male gonad development (GO:2000020)2.35042103
142positive regulation of histone deacetylation (GO:0031065)2.34209517
143ventricular system development (GO:0021591)2.34094049
144basement membrane organization (GO:0071711)2.33167839
145negative regulation of striated muscle cell apoptotic process (GO:0010664)2.32503762
146mesodermal cell differentiation (GO:0048333)2.30760340
147natural killer cell differentiation (GO:0001779)2.27318891
148fusion of sperm to egg plasma membrane (GO:0007342)2.27290965
149phagocytosis, recognition (GO:0006910)2.25194082
150bone trabecula formation (GO:0060346)2.25180094
151nuclear pore organization (GO:0006999)2.25106290
152androgen biosynthetic process (GO:0006702)2.24877710
153axonemal dynein complex assembly (GO:0070286)2.23236645
154glomerular filtration (GO:0003094)2.21721823
155regulation of nucleobase-containing compound transport (GO:0032239)2.18542783
156regulation of sarcomere organization (GO:0060297)2.16108696
157monoubiquitinated protein deubiquitination (GO:0035520)2.15297172
158T-helper 1 type immune response (GO:0042088)2.14269668
159pyrimidine nucleobase catabolic process (GO:0006208)2.13893881
160energy homeostasis (GO:0097009)2.13711353
161negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.13225521
162Rap protein signal transduction (GO:0032486)2.12742431
163regulation of macrophage cytokine production (GO:0010935)2.11060302
164glial cell proliferation (GO:0014009)2.10529627
165myeloid cell development (GO:0061515)2.09824685
166cell proliferation involved in metanephros development (GO:0072203)2.09120262
167response to interferon-alpha (GO:0035455)2.08472420
168I-kappaB phosphorylation (GO:0007252)2.08219055
169insulin-like growth factor receptor signaling pathway (GO:0048009)2.07727436
170endothelial cell morphogenesis (GO:0001886)2.07328523
171response to follicle-stimulating hormone (GO:0032354)2.05942527
172regulation of erythrocyte differentiation (GO:0045646)2.05343110
173tetrapyrrole biosynthetic process (GO:0033014)2.04644518
174dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.03476291
175heart valve formation (GO:0003188)2.02470375
176negative regulation of skeletal muscle tissue development (GO:0048642)2.02443457
177sperm motility (GO:0030317)2.01993723
178cardiac chamber formation (GO:0003207)2.01515571
179endodermal cell differentiation (GO:0035987)2.01321985
180negative regulation of granulocyte differentiation (GO:0030853)2.01217709
181chondrocyte proliferation (GO:0035988)2.00456438
182regulation of pigment cell differentiation (GO:0050932)2.00032094
183iron ion import (GO:0097286)1.99809355
184peptidyl-lysine dimethylation (GO:0018027)1.99458233
185multicellular organism reproduction (GO:0032504)1.99166500
186protein localization to cell surface (GO:0034394)1.99024472
187acrosome reaction (GO:0007340)1.98031893
188dermatan sulfate biosynthetic process (GO:0030208)1.97956321
189sperm-egg recognition (GO:0035036)1.97450234
190respiratory tube development (GO:0030323)1.97153747

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.54381178
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.23698062
3RBPJ_22232070_ChIP-Seq_NCS_Mouse3.20945722
4EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse3.03072279
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.99738326
6E2F4_17652178_ChIP-ChIP_JURKAT_Human2.93640445
7TRIM28_21343339_ChIP-Seq_HEK293_Human2.82183257
8GBX2_23144817_ChIP-Seq_PC3_Human2.58939733
9IRF8_22096565_ChIP-ChIP_GC-B_Human2.53721850
10STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.50505255
11EGR1_19374776_ChIP-ChIP_THP-1_Human2.47418723
12STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.47319233
13EWS_26573619_Chip-Seq_HEK293_Human2.47185034
14FOXM1_23109430_ChIP-Seq_U2OS_Human2.44179727
15ZFP57_27257070_Chip-Seq_ESCs_Mouse2.36147819
16* FUS_26573619_Chip-Seq_HEK293_Human2.31846287
17FLI1_27457419_Chip-Seq_LIVER_Mouse2.24095480
18* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.19504679
19CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.13835391
20SCL_19346495_ChIP-Seq_HPC-7_Human2.09988291
21TAF15_26573619_Chip-Seq_HEK293_Human2.08091524
22WT1_19549856_ChIP-ChIP_CCG9911_Human2.05332522
23P300_19829295_ChIP-Seq_ESCs_Human2.04537442
24* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.04202412
25EP300_21415370_ChIP-Seq_HL-1_Mouse2.00715749
26CDX2_19796622_ChIP-Seq_MESCs_Mouse1.98552411
27ELK1_19687146_ChIP-ChIP_HELA_Human1.97825463
28POU5F1_16153702_ChIP-ChIP_HESCs_Human1.93125215
29GATA1_19941826_ChIP-Seq_K562_Human1.90003989
30E2F7_22180533_ChIP-Seq_HELA_Human1.88141865
31AR_21909140_ChIP-Seq_LNCAP_Human1.82192327
32IRF8_27001747_Chip-Seq_BMDM_Mouse1.81483647
33PCGF2_27294783_Chip-Seq_ESCs_Mouse1.79960108
34ZNF274_21170338_ChIP-Seq_K562_Hela1.78235690
35SALL1_21062744_ChIP-ChIP_HESCs_Human1.76820935
36BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.76752231
37VDR_24787735_ChIP-Seq_THP-1_Human1.74442119
38VDR_22108803_ChIP-Seq_LS180_Human1.73716723
39FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.73466404
40CLOCK_20551151_ChIP-Seq_293T_Human1.72154664
41TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.70545583
42STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.69958623
43NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.67461050
44RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.66985468
45CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.65602220
46ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.65229562
47HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.64501179
48BP1_19119308_ChIP-ChIP_Hs578T_Human1.60870530
49MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.59554450
50KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.57905242
51OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.57848248
52NANOG_16153702_ChIP-ChIP_HESCs_Human1.56452711
53Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.56263781
54* BRD4_25478319_ChIP-Seq_HGPS_Human1.56081709
55SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.55649179
56PCGF2_27294783_Chip-Seq_NPCs_Mouse1.51855190
57STAT6_21828071_ChIP-Seq_BEAS2B_Human1.51506641
58MYB_21317192_ChIP-Seq_ERMYB_Mouse1.49927117
59CJUN_26792858_Chip-Seq_BT549_Human1.49477826
60* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.48832974
61* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.47904208
62MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.47600282
63SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.45276527
64GATA1_22025678_ChIP-Seq_K562_Human1.44347386
65EZH2_27294783_Chip-Seq_NPCs_Mouse1.44121604
66MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.42798480
67PIAS1_25552417_ChIP-Seq_VCAP_Human1.42751840
68SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.42586246
69IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.41659099
70SUZ12_27294783_Chip-Seq_NPCs_Mouse1.39026025
71IRF8_21731497_ChIP-ChIP_J774_Mouse1.38180943
72GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37261221
73NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.36319178
74GATA2_21666600_ChIP-Seq_HMVEC_Human1.35266155
75GATA1_19941827_ChIP-Seq_MEL_Mouse1.34134793
76SMAD4_21799915_ChIP-Seq_A2780_Human1.33922265
77KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.32553024
78KDM2B_26808549_Chip-Seq_DND41_Human1.31211178
79SMAD3_21741376_ChIP-Seq_EPCs_Human1.31096309
80GATA2_19941826_ChIP-Seq_K562_Human1.30662800
81SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.30492493
82SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.30492493
83SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.30441971
84TBX20_22080862_ChIP-Seq_HEART_Mouse1.29856811
85TBX20_22328084_ChIP-Seq_HEART_Mouse1.29856811
86TCF7_22412390_ChIP-Seq_EML_Mouse1.29493276
87TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.28943967
88TBX3_20139965_ChIP-Seq_ESCs_Mouse1.28210103
89KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.28110477
90SALL4_18804426_ChIP-ChIP_XEN_Mouse1.27960702
91CTBP2_25329375_ChIP-Seq_LNCAP_Human1.27644077
92TBX3_20139965_ChIP-Seq_MESCs_Mouse1.27279916
93ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.27177972
94SOX2_16153702_ChIP-ChIP_HESCs_Human1.26698879
95TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.26481979
96TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.26061607
97* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.25976000
98NFIB_24661679_ChIP-Seq_LUNG_Mouse1.25489295
99* STAT3_23295773_ChIP-Seq_U87_Human1.25317710
100RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.23553651
101ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.23014572
102GABP_17652178_ChIP-ChIP_JURKAT_Human1.22555745
103WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.21707367
104RUNX_20019798_ChIP-Seq_JUKART_Human1.21459429
105TOP2B_26459242_ChIP-Seq_MCF-7_Human1.21262257
106NFE2_27457419_Chip-Seq_LIVER_Mouse1.21099871
107TP53_16413492_ChIP-PET_HCT116_Human1.20082084
108SOX9_26525672_Chip-Seq_HEART_Mouse1.19587766
109MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.19260668
110BRD4_27068464_Chip-Seq_AML-cells_Mouse1.19231662
111CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.18912441
112KDM2B_26808549_Chip-Seq_SUP-B15_Human1.18832044
113ZNF263_19887448_ChIP-Seq_K562_Human1.18754710
114FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.18658421
115UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.18291789
116NANOG_18555785_Chip-Seq_ESCs_Mouse1.18084697
117MAF_26560356_Chip-Seq_TH1_Human1.17157063
118FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.16864884
119AR_21572438_ChIP-Seq_LNCaP_Human1.16754071
120TCF4_18268006_ChIP-ChIP_LS174T_Human1.16330879
121* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.15987549
122SMAD_19615063_ChIP-ChIP_OVARY_Human1.15099815
123SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.15026513
124TP53_18474530_ChIP-ChIP_U2OS_Human1.14876934
125TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.14868689
126PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14807204
127PADI4_21655091_ChIP-ChIP_MCF-7_Human1.14761329
128E2F1_21310950_ChIP-Seq_MCF-7_Human1.13765747
129ISL1_27105846_Chip-Seq_CPCs_Mouse1.12978688
130* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.12582119
131GATA4_21415370_ChIP-Seq_HL-1_Mouse1.12386425
132KDM2B_26808549_Chip-Seq_JURKAT_Human1.12108099
133PPAR_26484153_Chip-Seq_NCI-H1993_Human1.11177938
134TP63_19390658_ChIP-ChIP_HaCaT_Human1.11121299
135CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.10676965
136MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.10600159
137* JUN_21703547_ChIP-Seq_K562_Human1.09963782
138EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.08900038
139CTBP1_25329375_ChIP-Seq_LNCAP_Human1.08520717
140KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.08350702
141IGF1R_20145208_ChIP-Seq_DFB_Human1.07577498
142STAT4_19710469_ChIP-ChIP_TH1__Mouse1.06560457
143IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.06491508
144CBP_20019798_ChIP-Seq_JUKART_Human1.06491508
145MYC_18940864_ChIP-ChIP_HL60_Human1.05854929
146* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04609569
147E2F1_18555785_Chip-Seq_ESCs_Mouse1.04490505
148PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.04248627
149FOXM1_26456572_ChIP-Seq_MCF-7_Human1.04146508
150POU3F2_20337985_ChIP-ChIP_501MEL_Human1.03403662
151MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.03027915
152NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.02844310
153NRF2_20460467_ChIP-Seq_MEFs_Mouse1.02844310
154EST1_17652178_ChIP-ChIP_JURKAT_Human1.01931097
155PU_27001747_Chip-Seq_BMDM_Mouse1.01245301
156FOXO3_23340844_ChIP-Seq_DLD1_Human1.01070349
157SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.00746326
158NR3C1_21868756_ChIP-Seq_MCF10A_Human1.00735827
159STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.00726513
160IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.00606479
161PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.00204113
162KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.99841834
163P53_22387025_ChIP-Seq_ESCs_Mouse0.99740693
164RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.99715154
165NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.99582141
166UBF1/2_26484160_Chip-Seq_HMECs_Human0.98819374
167VDR_24763502_ChIP-Seq_THP-1_Human0.98152204
168ARNT_22903824_ChIP-Seq_MCF-7_Human0.97426708
169CRX_20693478_ChIP-Seq_RETINA_Mouse0.96952114
170TCF4_23295773_ChIP-Seq_U87_Human0.96510713
171SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.96411385
172MYB_26560356_Chip-Seq_TH2_Human0.96196391
173RARG_19884340_ChIP-ChIP_MEFs_Mouse0.95358149
174ER_23166858_ChIP-Seq_MCF-7_Human0.94890209
175AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.94729633
176GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.93841837

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.32433137
2MP0000569_abnormal_digit_pigmentation3.29658371
3MP0003941_abnormal_skin_development3.27015414
4MP0005503_abnormal_tendon_morphology2.89345088
5MP0008057_abnormal_DNA_replication2.62725446
6MP0003656_abnormal_erythrocyte_physiolo2.58506959
7MP0005171_absent_coat_pigmentation2.49742405
8MP0003705_abnormal_hypodermis_morpholog2.45361981
9MP0010094_abnormal_chromosome_stability2.36448509
10MP0003890_abnormal_embryonic-extraembry2.34492837
11MP0005623_abnormal_meninges_morphology2.33754105
12MP0006054_spinal_hemorrhage2.23933789
13MP0003136_yellow_coat_color2.20712403
14MP0003279_aneurysm2.19770327
15MP0001299_abnormal_eye_distance/2.13235185
16MP0004272_abnormal_basement_membrane2.07605124
17MP0003828_pulmonary_edema2.03696950
18MP0010030_abnormal_orbit_morphology2.02578351
19MP0004957_abnormal_blastocyst_morpholog2.02362940
20MP0008932_abnormal_embryonic_tissue1.99700480
21MP0004808_abnormal_hematopoietic_stem1.95511306
22MP0003111_abnormal_nucleus_morphology1.94919518
23MP0010368_abnormal_lymphatic_system1.94448980
24MP0003693_abnormal_embryo_hatching1.82728170
25MP0001879_abnormal_lymphatic_vessel1.82525689
26MP0000733_abnormal_muscle_development1.81117828
27MP0001545_abnormal_hematopoietic_system1.80176042
28MP0005397_hematopoietic_system_phenotyp1.80176042
29MP0005410_abnormal_fertilization1.78971067
30MP0005076_abnormal_cell_differentiation1.76547608
31MP0009053_abnormal_anal_canal1.74881219
32MP0004084_abnormal_cardiac_muscle1.74471124
33MP0001293_anophthalmia1.71754364
34MP0001958_emphysema1.71716130
35MP0002102_abnormal_ear_morphology1.71000056
36MP0009278_abnormal_bone_marrow1.70674326
37MP0003300_gastrointestinal_ulcer1.67158815
38MP0005257_abnormal_intraocular_pressure1.66105645
39MP0008775_abnormal_heart_ventricle1.64019707
40MP0005275_abnormal_skin_tensile1.62818163
41MP0003077_abnormal_cell_cycle1.62180532
42MP0003303_peritoneal_inflammation1.61700846
43MP0008058_abnormal_DNA_repair1.59534932
44MP0000372_irregular_coat_pigmentation1.58028116
45MP0003385_abnormal_body_wall1.54254609
46MP0003091_abnormal_cell_migration1.52807117
47MP0002138_abnormal_hepatobiliary_system1.50662807
48MP0009250_abnormal_appendicular_skeleto1.50223209
49MP0010630_abnormal_cardiac_muscle1.43511590
50MP0000685_abnormal_immune_system1.43033112
51MP0003755_abnormal_palate_morphology1.39380550
52MP0003115_abnormal_respiratory_system1.38502573
53MP0003718_maternal_effect1.37589303
54MP0002084_abnormal_developmental_patter1.36810757
55MP0003119_abnormal_digestive_system1.36673088
56MP0004147_increased_porphyrin_level1.35799844
57MP0000537_abnormal_urethra_morphology1.34247401
58MP0001286_abnormal_eye_development1.32754054
59MP0000767_abnormal_smooth_muscle1.30881583
60MP0003566_abnormal_cell_adhesion1.30792674
61MP0002254_reproductive_system_inflammat1.29514893
62MP0001348_abnormal_lacrimal_gland1.28866000
63MP0002282_abnormal_trachea_morphology1.27620884
64MP0003567_abnormal_fetal_cardiomyocyte1.27037008
65MP0008007_abnormal_cellular_replicative1.25041534
66MP0002085_abnormal_embryonic_tissue1.23599503
67MP0004510_myositis1.22305372
68MP0000428_abnormal_craniofacial_morphol1.21397677
69MP0006292_abnormal_olfactory_placode1.20493855
70MP0005197_abnormal_uvea_morphology1.18280514
71MP0003942_abnormal_urinary_system1.17340836
72MP0009697_abnormal_copulation1.16989296
73MP0001542_abnormal_bone_strength1.16253620
74MP0002128_abnormal_blood_circulation1.14756869
75MP0001835_abnormal_antigen_presentation1.14575984
76MP0000432_abnormal_head_morphology1.14119297
77MP0002925_abnormal_cardiovascular_devel1.12596760
78MP0001177_atelectasis1.11991286
79MP0005408_hypopigmentation1.10406852
80MP0009384_cardiac_valve_regurgitation1.09687423
81MP0002972_abnormal_cardiac_muscle1.09451105
82MP0001697_abnormal_embryo_size1.08928847
83MP0004130_abnormal_muscle_cell1.08727693
84MP0005380_embryogenesis_phenotype1.07728034
85MP0001672_abnormal_embryogenesis/_devel1.07728034
86MP0003937_abnormal_limbs/digits/tail_de1.04799621
87MP0000266_abnormal_heart_morphology1.03210835
88MP0005385_cardiovascular_system_phenoty1.02794547
89MP0001544_abnormal_cardiovascular_syste1.02794547
90MP0005248_abnormal_Harderian_gland1.01649174
91MP0001915_intracranial_hemorrhage1.01046620
92MP0000647_abnormal_sebaceous_gland1.00231206
93MP0002877_abnormal_melanocyte_morpholog0.99967463
94MP0002234_abnormal_pharynx_morphology0.99528838
95MP0003935_abnormal_craniofacial_develop0.98938581
96MP0001614_abnormal_blood_vessel0.98886375
97MP0003448_altered_tumor_morphology0.97267840
98MP0010352_gastrointestinal_tract_polyps0.97191712
99MP0004087_abnormal_muscle_fiber0.96655323
100MP0005187_abnormal_penis_morphology0.96252225
101MP0003943_abnormal_hepatobiliary_system0.95881896
102MP0003984_embryonic_growth_retardation0.94425646
103MP0010307_abnormal_tumor_latency0.93952824
104MP0000751_myopathy0.93857144
105MP0006072_abnormal_retinal_apoptosis0.92746476
106MP0002396_abnormal_hematopoietic_system0.91818043
107MP0004185_abnormal_adipocyte_glucose0.90198402
108MP0000350_abnormal_cell_proliferation0.90189150
109MP0000762_abnormal_tongue_morphology0.90021327
110MP0008995_early_reproductive_senescence0.89723666
111MP0003646_muscle_fatigue0.89503039
112MP0003121_genomic_imprinting0.89125411
113MP0001188_hyperpigmentation0.88846003
114MP0004215_abnormal_myocardial_fiber0.88770151
115MP0001730_embryonic_growth_arrest0.88520879
116MP0000534_abnormal_ureter_morphology0.88502734
117MP0009672_abnormal_birth_weight0.88381765
118MP0009703_decreased_birth_body0.88304689
119MP0002133_abnormal_respiratory_system0.86810059
120MP0005388_respiratory_system_phenotype0.86810059
121MP0005084_abnormal_gallbladder_morpholo0.86638110
122MP0004133_heterotaxia0.85030668
123MP0004197_abnormal_fetal_growth/weight/0.84403421
124MP0002938_white_spotting0.83268968
125MP0000049_abnormal_middle_ear0.82221298
126MP0002751_abnormal_autonomic_nervous0.82215269
127MP0001346_abnormal_lacrimal_gland0.82030199
128MP0005508_abnormal_skeleton_morphology0.80996280
129MP0008877_abnormal_DNA_methylation0.80876431
130MP0002233_abnormal_nose_morphology0.80731510
131MP0001929_abnormal_gametogenesis0.80554984
132MP0005387_immune_system_phenotype0.79447452
133MP0001790_abnormal_immune_system0.79447452
134MP0002295_abnormal_pulmonary_circulatio0.78454660
135MP0003950_abnormal_plasma_membrane0.78386252
136MP0002896_abnormal_bone_mineralization0.78215144
137MP0002111_abnormal_tail_morphology0.78119518
138MP0002092_abnormal_eye_morphology0.77865172
139MP0006138_congestive_heart_failure0.77802029
140MP0002060_abnormal_skin_morphology0.76792673
141MP0000749_muscle_degeneration0.76486846
142MP0002210_abnormal_sex_determination0.76349003
143MP0000371_diluted_coat_color0.76196003
144MP0001175_abnormal_lung_morphology0.75797654
145MP0005174_abnormal_tail_pigmentation0.75313709
146MP0002177_abnormal_outer_ear0.75121349
147MP0000778_abnormal_nervous_system0.75023454
148MP0002998_abnormal_bone_remodeling0.74837500
149MP0002168_other_aberrant_phenotype0.73706358
150MP0002088_abnormal_embryonic_growth/wei0.73371188
151MP0002009_preneoplasia0.73010960
152MP0002398_abnormal_bone_marrow0.72250196
153MP0002697_abnormal_eye_size0.72016551
154MP0002405_respiratory_system_inflammati0.71931151
155MP0002086_abnormal_extraembryonic_tissu0.71757993
156MP0002109_abnormal_limb_morphology0.71736944

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.05607323
2Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.50642525
3Short 4th metacarpal (HP:0010044)3.50642525
4Protrusio acetabuli (HP:0003179)3.41414041
5Premature rupture of membranes (HP:0001788)3.18848933
6Shallow orbits (HP:0000586)3.18361241
7Spinal cord lesions (HP:0100561)3.04635766
8Syringomyelia (HP:0003396)3.04635766
9Abnormality of the heme biosynthetic pathway (HP:0010472)2.98802154
10Abnormality of the 4th metacarpal (HP:0010012)2.93463975
11Poikilocytosis (HP:0004447)2.82236474
12Ankle contracture (HP:0006466)2.78622370
13Subacute progressive viral hepatitis (HP:0006572)2.74187441
14Aortic dissection (HP:0002647)2.71989569
15Colon cancer (HP:0003003)2.71669439
16Absent frontal sinuses (HP:0002688)2.68735960
17Dynein arm defect of respiratory motile cilia (HP:0012255)2.56345751
18Absent/shortened dynein arms (HP:0200106)2.56345751
19Meckel diverticulum (HP:0002245)2.53369882
20Aortic aneurysm (HP:0004942)2.52736593
21Bladder diverticulum (HP:0000015)2.48458349
22Abnormality of chromosome stability (HP:0003220)2.47584420
23Abnormality of the ileum (HP:0001549)2.42650153
24Asymmetry of the thorax (HP:0001555)2.42609213
25Aplasia/Hypoplasia of the uvula (HP:0010293)2.42336206
26Abnormal lung lobation (HP:0002101)2.41415019
27Dilatation of the ascending aorta (HP:0005111)2.39421494
28Embryonal renal neoplasm (HP:0011794)2.37874476
29Chromosomal breakage induced by crosslinking agents (HP:0003221)2.37497553
30Abnormal respiratory motile cilium physiology (HP:0012261)2.36566669
31Broad metatarsal (HP:0001783)2.36151054
32Chromsome breakage (HP:0040012)2.33014260
33Cerebral aneurysm (HP:0004944)2.31341056
34Small hand (HP:0200055)2.30674630
35Birth length less than 3rd percentile (HP:0003561)2.29973465
36Osteolytic defects of the phalanges of the hand (HP:0009771)2.29940215
37Osteolytic defects of the hand bones (HP:0009699)2.29940215
38Abnormality of the peritoneum (HP:0002585)2.28825573
39Nephroblastoma (Wilms tumor) (HP:0002667)2.28405784
40Septo-optic dysplasia (HP:0100842)2.27233115
41Type 1 muscle fiber predominance (HP:0003803)2.24688709
42Short hallux (HP:0010109)2.23012727
43Abnormality of dentin (HP:0010299)2.20518879
44Preaxial foot polydactyly (HP:0001841)2.19764280
45Subaortic stenosis (HP:0001682)2.18375955
46Abnormality of the left ventricular outflow tract (HP:0011103)2.18375955
47Aplasia/Hypoplasia of the hallux (HP:0008362)2.15256312
48Abnormality of the labia minora (HP:0012880)2.14983169
49Mitral valve prolapse (HP:0001634)2.14974887
50Rhinitis (HP:0012384)2.14667609
51Abnormal auditory evoked potentials (HP:0006958)2.13419962
52Nasal polyposis (HP:0100582)2.12923910
53Heterotopia (HP:0002282)2.10652617
54Aplasia/Hypoplasia of the tibia (HP:0005772)2.10594226
55Cortical dysplasia (HP:0002539)2.08169732
56Lymphangioma (HP:0100764)2.06650035
57Bifid tongue (HP:0010297)2.04334787
58Lipoatrophy (HP:0100578)2.02655220
59Atrophic scars (HP:0001075)2.00616223
60Neoplasm of the colon (HP:0100273)1.99921859
61Short middle phalanx of the 5th finger (HP:0004220)1.99725532
62Duodenal stenosis (HP:0100867)1.99470264
63Small intestinal stenosis (HP:0012848)1.99470264
64Ectopic kidney (HP:0000086)1.98063216
65Midline defect of the nose (HP:0004122)1.97532355
66Diaphragmatic weakness (HP:0009113)1.96435248
67Broad palm (HP:0001169)1.96391506
68Peritonitis (HP:0002586)1.96184512
69Follicular hyperkeratosis (HP:0007502)1.96116502
70Soft skin (HP:0000977)1.95854621
71Arterial tortuosity (HP:0005116)1.92643761
72Abnormality of the nasal mucosa (HP:0000433)1.91673902
73Bowel diverticulosis (HP:0005222)1.88587396
74Fibular hypoplasia (HP:0003038)1.88379586
75Aplasia/Hypoplasia of the sternum (HP:0006714)1.88064586
76Microglossia (HP:0000171)1.87827923
77Neoplasm of the adrenal cortex (HP:0100641)1.86675339
78Pachygyria (HP:0001302)1.86330263
79Rhabdomyosarcoma (HP:0002859)1.85513706
80Short tibia (HP:0005736)1.85351112
81Long nose (HP:0003189)1.84328875
82Trigonocephaly (HP:0000243)1.84131815
83Deviation of the hallux (HP:0010051)1.84093273
84Hyperacusis (HP:0010780)1.83660520
85Disinhibition (HP:0000734)1.83592998
86Ependymoma (HP:0002888)1.80810324
87Macroorchidism (HP:0000053)1.80621777
88Hallux valgus (HP:0001822)1.80546869
89Bell-shaped thorax (HP:0001591)1.80293659
90Pulmonary artery stenosis (HP:0004415)1.80207821
91Flat cornea (HP:0007720)1.80155360
92Bicuspid aortic valve (HP:0001647)1.79486447
93Abnormality of the duodenum (HP:0002246)1.79324445
94Wrist flexion contracture (HP:0001239)1.78479045
95Insomnia (HP:0100785)1.78364596
96Wormian bones (HP:0002645)1.77259291
97Slender build (HP:0001533)1.76900063
98Rectal prolapse (HP:0002035)1.76836781
99Renovascular hypertension (HP:0100817)1.76527232
100Overgrowth (HP:0001548)1.76520312
101Wide anterior fontanel (HP:0000260)1.76512025
102Prostate neoplasm (HP:0100787)1.76279867
103Glioma (HP:0009733)1.76085493
104Atrial fibrillation (HP:0005110)1.75565744
105Joint laxity (HP:0001388)1.75295452
106Neoplasm of the oral cavity (HP:0100649)1.74449580
107Narrow palate (HP:0000189)1.74447359
108Acanthocytosis (HP:0001927)1.74249569
109Viral hepatitis (HP:0006562)1.73223021
110Buphthalmos (HP:0000557)1.72608434
111Broad ribs (HP:0000885)1.72425486
112Abnormality of the carotid arteries (HP:0005344)1.72220621
113Spastic diplegia (HP:0001264)1.72088021
114Reticulocytosis (HP:0001923)1.71927252
115Abnormality of the phalanges of the 2nd finger (HP:0009541)1.71210820
116Volvulus (HP:0002580)1.70834731
117Spinal rigidity (HP:0003306)1.70564387
118Medulloblastoma (HP:0002885)1.70528003
119Mesomelia (HP:0003027)1.69792079
120Chorioretinal atrophy (HP:0000533)1.69584188
121Primary atrial arrhythmia (HP:0001692)1.69468583
122Fragile skin (HP:0001030)1.69236993
123Disproportionate tall stature (HP:0001519)1.68848404
124Skull defect (HP:0001362)1.68387013
125Neoplasm of the small intestine (HP:0100833)1.66943402
126Deep philtrum (HP:0002002)1.66818595
127Exostoses (HP:0100777)1.66802107
128Enlarged penis (HP:0000040)1.66649702
129Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.66009964
130Abnormal ciliary motility (HP:0012262)1.65783290
131Coronal craniosynostosis (HP:0004440)1.64994327
132Hematochezia (HP:0002573)1.64660854
133Polycythemia (HP:0001901)1.64616909
134Aplasia/Hypoplasia of the fibula (HP:0006492)1.63653612
135Increased connective tissue (HP:0009025)1.63484699
136Scapular winging (HP:0003691)1.63148626
137Neoplasm of the rectum (HP:0100743)1.63145380
138Abnormality of the middle phalanges of the toes (HP:0010183)1.62888084
139Increased number of teeth (HP:0011069)1.62871732
140Morphological abnormality of the middle ear (HP:0008609)1.62222012
141Cutaneous finger syndactyly (HP:0010554)1.62207073
142Abnormality of the septum pellucidum (HP:0007375)1.61412424
143Pulmonic stenosis (HP:0001642)1.60703608
144Gastrointestinal infarctions (HP:0005244)1.60654624
145Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.60037066
146Absent eyebrow (HP:0002223)1.57996154
147Limb-girdle muscle weakness (HP:0003325)1.57483858
148Limited hip movement (HP:0008800)1.56963051
149Neonatal short-limb short stature (HP:0008921)1.56423358
150Intestinal atresia (HP:0011100)1.56373499
151Long eyelashes (HP:0000527)1.56217340
152Supraventricular arrhythmia (HP:0005115)1.56046723
153Vascular tortuosity (HP:0004948)1.55618227
154Increased nuchal translucency (HP:0010880)1.55259846
155Abnormal respiratory epithelium morphology (HP:0012253)1.54850254
156Abnormal respiratory motile cilium morphology (HP:0005938)1.54850254
157Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.54502784
158Neonatal hypoglycemia (HP:0001998)1.54359478
159Astrocytoma (HP:0009592)1.54299001
160Abnormality of the astrocytes (HP:0100707)1.54299001
161Mitral regurgitation (HP:0001653)1.54298221
162Biliary tract neoplasm (HP:0100574)1.53636927
163Delayed gross motor development (HP:0002194)1.53018200
164Benign neoplasm of the central nervous system (HP:0100835)1.52793524
165Genu recurvatum (HP:0002816)1.52607566
166Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.51727746
167Sloping forehead (HP:0000340)1.51074658
168Fibular aplasia (HP:0002990)1.50465121
169Dandy-Walker malformation (HP:0001305)1.50169172
170Hypoplastic pelvis (HP:0008839)1.49839452
171Absent radius (HP:0003974)1.49388168
172Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.48031834
173Myelomeningocele (HP:0002475)1.47800907
174Aplasia/Hypoplasia of the fovea (HP:0008060)1.47230209
175Hypoplasia of the fovea (HP:0007750)1.47230209
176Abnormality of the preputium (HP:0100587)1.46771010
177Protruding tongue (HP:0010808)1.46184527
178Congenital, generalized hypertrichosis (HP:0004540)1.45276410

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB12.91077711
2TRIB32.90113359
3MKNK22.89932137
4MARK12.73247914
5TTN2.69533800
6PKN22.62683978
7EPHB22.54189662
8BMPR1B2.52442203
9TTK2.49055303
10TNIK2.47058341
11WEE12.45242439
12TSSK62.40931524
13MKNK12.34634004
14PLK32.32337441
15BRSK22.31299054
16STK32.19470293
17DMPK2.17560196
18RIPK12.10483455
19NEK12.09183872
20STK38L2.06991577
21ERBB31.96963406
22EPHA31.90679523
23MAP3K101.89963277
24PNCK1.87876773
25LATS11.86142269
26NME21.82685985
27MAP3K141.82562426
28ACVR1B1.79963844
29PBK1.76789178
30TRIM281.76734460
31CDK121.72109755
32FRK1.71450155
33PLK41.71010173
34BCR1.69821297
35TAF11.68409884
36STK41.66814694
37EIF2AK31.64735134
38ERBB41.63368158
39TESK11.61234071
40SRPK11.59835231
41EEF2K1.58996527
42PDK41.57214774
43PDK31.57214774
44TGFBR21.53401510
45CDK61.53185902
46TRPM71.51039898
47PTK2B1.47223448
48SIK11.44877209
49DYRK21.42072443
50PLK21.39440648
51AKT31.35266419
52LATS21.34690658
53INSRR1.34621343
54WNK31.34560317
55STK241.34202061
56PLK11.32041154
57PDGFRA1.30184271
58EPHB11.25969745
59CASK1.25168938
60PTK61.24079656
61CLK11.23342806
62NEK91.22031749
63ZAK1.20907038
64CHUK1.18880031
65EIF2AK11.18474311
66CDC71.15392765
67TBK11.15190689
68FGFR31.09708029
69PAK21.09257397
70CHEK21.04950032
71MET1.04942250
72MYLK1.02556742
73JAK31.01609105
74JAK10.99826028
75NUAK10.97669814
76BMX0.96253987
77RPS6KA40.94941737
78PIK3CA0.94623858
79MELK0.94500398
80VRK10.94392344
81ILK0.94085116
82PDGFRB0.91380735
83PIM10.88743455
84STK100.88156908
85DYRK30.87916598
86TYK20.86453249
87NLK0.86394929
88DDR20.84341754
89TGFBR10.83825237
90CDK90.82925457
91DYRK1B0.82270127
92MTOR0.82132950
93LIMK10.81512446
94PHKG10.80664046
95PHKG20.80664046
96PDK20.79810877
97IKBKB0.79570143
98FLT30.78393040
99BRD40.76883567
100SCYL20.76203823
101MAPK130.74262081
102HCK0.68801730
103ROCK10.68249411
104CAMK1D0.68074552
105EIF2AK20.67779380
106PKN10.67327450
107AURKB0.66231446
108TIE10.66226848
109NEK20.66179209
110KIT0.65903797
111RET0.65077822
112OBSCN0.63775421
113YES10.63733249
114WNK10.62900723
115CDK40.62636277
116CSNK1G10.62614698
117CSF1R0.60654547
118NTRK10.60161263
119LMTK20.59153350
120RPS6KA20.58371204
121RPS6KA10.58110378
122BRSK10.57961755
123GSK3A0.56895808
124MST40.56768054
125CDK80.56422710
126LRRK20.56076890
127ATM0.55887852
128PRKCE0.54963785
129ADRBK10.54749880
130PTK20.54103473
131ADRBK20.53905771
132SIK20.53220715
133PAK30.52761430
134CSNK1A1L0.51706387
135ATR0.51134727
136EGFR0.51102449
137CHEK10.50344533
138PRKD10.49300860
139MAPKAPK20.48966390
140JAK20.46982181
141CDK30.46489514
142GRK10.46354137
143CSNK1D0.45579897
144PRKCQ0.44789776
145CSNK1G20.42846642
146FGFR20.42541983
147ABL10.42465581
148AKT10.42220229
149CAMK1G0.41475164
150RPS6KA60.40076540
151ERBB20.39872526
152RPS6KA50.39324228
153FGFR10.39037965
154MAP3K50.38577150
155MAP3K40.38043784
156TEC0.35364347
157PAK40.34552911
158CCNB10.34027890
159PRKDC0.33556151
160PIK3CG0.32732178
161CDK10.28948578
162IGF1R0.27716356
163CDK70.27220653

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034503.47327821
2Mismatch repair_Homo sapiens_hsa034302.98315301
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.91109959
4Viral myocarditis_Homo sapiens_hsa054162.52606993
5DNA replication_Homo sapiens_hsa030302.41681256
6Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.38612741
7Homologous recombination_Homo sapiens_hsa034402.38466168
8Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.38052363
9One carbon pool by folate_Homo sapiens_hsa006702.27533692
10Selenocompound metabolism_Homo sapiens_hsa004502.24103331
11Fanconi anemia pathway_Homo sapiens_hsa034602.21892115
12Protein export_Homo sapiens_hsa030602.08073840
13Proteasome_Homo sapiens_hsa030502.06180129
14RNA transport_Homo sapiens_hsa030132.02550559
15Basal transcription factors_Homo sapiens_hsa030222.02304342
16Steroid biosynthesis_Homo sapiens_hsa001001.95282702
17Small cell lung cancer_Homo sapiens_hsa052221.92394573
18Chronic myeloid leukemia_Homo sapiens_hsa052201.88316532
19Nucleotide excision repair_Homo sapiens_hsa034201.87846544
20RNA degradation_Homo sapiens_hsa030181.86740780
21Toxoplasmosis_Homo sapiens_hsa051451.83078377
22AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.75200408
23ECM-receptor interaction_Homo sapiens_hsa045121.74759440
24Focal adhesion_Homo sapiens_hsa045101.69313937
25Leishmaniasis_Homo sapiens_hsa051401.65737735
26RNA polymerase_Homo sapiens_hsa030201.65395846
27Osteoclast differentiation_Homo sapiens_hsa043801.61969319
28Measles_Homo sapiens_hsa051621.58841932
29Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.51948104
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.51944818
31MicroRNAs in cancer_Homo sapiens_hsa052061.51634949
32Malaria_Homo sapiens_hsa051441.51358777
33Cysteine and methionine metabolism_Homo sapiens_hsa002701.46686372
34B cell receptor signaling pathway_Homo sapiens_hsa046621.46122950
35Toll-like receptor signaling pathway_Homo sapiens_hsa046201.44087991
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.44053478
37Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.43113268
38Dilated cardiomyopathy_Homo sapiens_hsa054141.41104028
39Pancreatic cancer_Homo sapiens_hsa052121.38340893
40Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.37928844
41Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.33228002
42Proteoglycans in cancer_Homo sapiens_hsa052051.32397136
43Dorso-ventral axis formation_Homo sapiens_hsa043201.29951927
44NF-kappa B signaling pathway_Homo sapiens_hsa040641.27135012
45TNF signaling pathway_Homo sapiens_hsa046681.26694290
46Propanoate metabolism_Homo sapiens_hsa006401.26686989
47Hepatitis B_Homo sapiens_hsa051611.26185176
48HTLV-I infection_Homo sapiens_hsa051661.24621760
49Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.24014499
50Systemic lupus erythematosus_Homo sapiens_hsa053221.22031492
51Jak-STAT signaling pathway_Homo sapiens_hsa046301.21939289
52Axon guidance_Homo sapiens_hsa043601.21835419
53Herpes simplex infection_Homo sapiens_hsa051681.20604995
54Apoptosis_Homo sapiens_hsa042101.20468223
55Platelet activation_Homo sapiens_hsa046111.20025625
56Adherens junction_Homo sapiens_hsa045201.19706588
57Colorectal cancer_Homo sapiens_hsa052101.18693574
58Amoebiasis_Homo sapiens_hsa051461.18647606
59Prolactin signaling pathway_Homo sapiens_hsa049171.16955644
60Viral carcinogenesis_Homo sapiens_hsa052031.16253184
61Transcriptional misregulation in cancer_Homo sapiens_hsa052021.15833629
62Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.14553429
63Allograft rejection_Homo sapiens_hsa053301.14201671
64Spliceosome_Homo sapiens_hsa030401.13950781
65Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.12245385
66Oocyte meiosis_Homo sapiens_hsa041141.11921730
67Influenza A_Homo sapiens_hsa051641.09842227
68Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.09005708
69Prostate cancer_Homo sapiens_hsa052151.04387061
70Renal cell carcinoma_Homo sapiens_hsa052111.04355069
71Basal cell carcinoma_Homo sapiens_hsa052171.02518265
72Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.02480563
73Ovarian steroidogenesis_Homo sapiens_hsa049131.02387736
74Leukocyte transendothelial migration_Homo sapiens_hsa046701.02077884
75Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.98840755
76p53 signaling pathway_Homo sapiens_hsa041150.98444121
77Intestinal immune network for IgA production_Homo sapiens_hsa046720.98219185
78Hematopoietic cell lineage_Homo sapiens_hsa046400.97943726
79Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.97823817
80TGF-beta signaling pathway_Homo sapiens_hsa043500.96183716
81Endometrial cancer_Homo sapiens_hsa052130.96105041
82Notch signaling pathway_Homo sapiens_hsa043300.94897310
83Non-small cell lung cancer_Homo sapiens_hsa052230.94353657
84NOD-like receptor signaling pathway_Homo sapiens_hsa046210.93976446
85FoxO signaling pathway_Homo sapiens_hsa040680.91689875
86PI3K-Akt signaling pathway_Homo sapiens_hsa041510.90789480
87Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.90428375
88Tight junction_Homo sapiens_hsa045300.90315948
89Cell cycle_Homo sapiens_hsa041100.90150865
90Insulin resistance_Homo sapiens_hsa049310.89481550
91Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.88861734
92Lysine degradation_Homo sapiens_hsa003100.88855517
93Chemokine signaling pathway_Homo sapiens_hsa040620.88822655
94Purine metabolism_Homo sapiens_hsa002300.88486199
95Thyroid hormone signaling pathway_Homo sapiens_hsa049190.88148691
96Hippo signaling pathway_Homo sapiens_hsa043900.87896742
97Salmonella infection_Homo sapiens_hsa051320.87476947
98Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.87195231
99Pathways in cancer_Homo sapiens_hsa052000.87157287
100Pyrimidine metabolism_Homo sapiens_hsa002400.86862618
101Adipocytokine signaling pathway_Homo sapiens_hsa049200.86625321
102Acute myeloid leukemia_Homo sapiens_hsa052210.86171303
103Pertussis_Homo sapiens_hsa051330.85344046
104Glioma_Homo sapiens_hsa052140.85054269
105Neurotrophin signaling pathway_Homo sapiens_hsa047220.84485452
106Regulation of actin cytoskeleton_Homo sapiens_hsa048100.82067562
107Legionellosis_Homo sapiens_hsa051340.81896469
108mRNA surveillance pathway_Homo sapiens_hsa030150.81576573
109T cell receptor signaling pathway_Homo sapiens_hsa046600.78972895
110Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.78899658
111Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.77910046
112Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.77721138
113Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.77525848
114Wnt signaling pathway_Homo sapiens_hsa043100.77073856
115AMPK signaling pathway_Homo sapiens_hsa041520.75155413
116Graft-versus-host disease_Homo sapiens_hsa053320.72682645
117Base excision repair_Homo sapiens_hsa034100.72333704
118Sulfur metabolism_Homo sapiens_hsa009200.72250979
119Pyruvate metabolism_Homo sapiens_hsa006200.70738388
120Protein digestion and absorption_Homo sapiens_hsa049740.70035235
121Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.69666962
122Shigellosis_Homo sapiens_hsa051310.67640540
123HIF-1 signaling pathway_Homo sapiens_hsa040660.67346745
124Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.67088392
125Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.67009471
126Hedgehog signaling pathway_Homo sapiens_hsa043400.66296580
127Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.66198679
128Longevity regulating pathway - mammal_Homo sapiens_hsa042110.65941754
129Tuberculosis_Homo sapiens_hsa051520.64686519
130RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.64518987
131Phagosome_Homo sapiens_hsa041450.64369401
132Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.62938335
133Insulin signaling pathway_Homo sapiens_hsa049100.62132812
134Melanoma_Homo sapiens_hsa052180.61649637
135Antigen processing and presentation_Homo sapiens_hsa046120.60579916
136Central carbon metabolism in cancer_Homo sapiens_hsa052300.60036956
137Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.59966466
138Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.58107314
139N-Glycan biosynthesis_Homo sapiens_hsa005100.56833384
140Thyroid cancer_Homo sapiens_hsa052160.55082449
141Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.54968454
142Melanogenesis_Homo sapiens_hsa049160.46330513
143Phototransduction_Homo sapiens_hsa047440.45825690
144Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.44012558
145Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.41432433
146Bladder cancer_Homo sapiens_hsa052190.39538736
147Gap junction_Homo sapiens_hsa045400.39168406
148Rap1 signaling pathway_Homo sapiens_hsa040150.37348132
149Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.36822942
150Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.36765850
151Taste transduction_Homo sapiens_hsa047420.35231958
152Ras signaling pathway_Homo sapiens_hsa040140.32092190
153Nicotine addiction_Homo sapiens_hsa050330.30505865
154Alcoholism_Homo sapiens_hsa050340.30299870
155Nitrogen metabolism_Homo sapiens_hsa009100.30064961
156Primary bile acid biosynthesis_Homo sapiens_hsa001200.28883923
157Vitamin digestion and absorption_Homo sapiens_hsa049770.28136308
158cGMP-PKG signaling pathway_Homo sapiens_hsa040220.25142763
159Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.21688743
160Vascular smooth muscle contraction_Homo sapiens_hsa042700.20365563
161Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.16143913
162Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.15088820

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