FAM126B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1vocalization behavior (GO:0071625)5.47091509
2cornea development in camera-type eye (GO:0061303)5.33576119
3regulation of short-term neuronal synaptic plasticity (GO:0048172)5.25391911
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.17119667
5neuron cell-cell adhesion (GO:0007158)5.08679161
6regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.92433193
7presynaptic membrane assembly (GO:0097105)4.91231544
8synaptic vesicle exocytosis (GO:0016079)4.87417054
9glutamate secretion (GO:0014047)4.86203513
10regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.83719963
11ionotropic glutamate receptor signaling pathway (GO:0035235)4.83388329
12neurotransmitter-gated ion channel clustering (GO:0072578)4.71548406
13glutamate receptor signaling pathway (GO:0007215)4.63418175
14neuronal action potential propagation (GO:0019227)4.59547858
15protein localization to synapse (GO:0035418)4.56364860
16gamma-aminobutyric acid signaling pathway (GO:0007214)4.54299733
17presynaptic membrane organization (GO:0097090)4.54134360
18regulation of glutamate receptor signaling pathway (GO:1900449)4.53576273
19neuron-neuron synaptic transmission (GO:0007270)4.45744836
20synaptic transmission, glutamatergic (GO:0035249)4.41107557
21regulation of synaptic vesicle exocytosis (GO:2000300)4.34131287
22activated T cell proliferation (GO:0050798)4.23465313
23negative regulation of synaptic transmission, GABAergic (GO:0032229)4.23083810
24locomotory exploration behavior (GO:0035641)4.18591869
25positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.13261715
26neurotransmitter secretion (GO:0007269)4.13095357
27synaptic vesicle maturation (GO:0016188)4.04405322
28proline transport (GO:0015824)4.03895359
29synaptic vesicle docking involved in exocytosis (GO:0016081)3.98993864
30regulation of synaptic vesicle transport (GO:1902803)3.96810151
31neural tube formation (GO:0001841)3.94310260
32G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.92243721
33gamma-aminobutyric acid transport (GO:0015812)3.87191698
34postsynaptic membrane organization (GO:0001941)3.84542250
35regulation of excitatory postsynaptic membrane potential (GO:0060079)3.83523653
36regulation of long-term neuronal synaptic plasticity (GO:0048169)3.77934989
37long-term synaptic potentiation (GO:0060291)3.75737756
38startle response (GO:0001964)3.75560799
39response to histamine (GO:0034776)3.73092688
40regulation of postsynaptic membrane potential (GO:0060078)3.69033487
41positive regulation of synapse maturation (GO:0090129)3.68882574
42regulation of B cell receptor signaling pathway (GO:0050855)3.66475277
43regulation of synaptic transmission, glutamatergic (GO:0051966)3.66198739
44cerebellar granule cell differentiation (GO:0021707)3.65080047
45regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.64848260
46regulation of timing of cell differentiation (GO:0048505)3.63322803
47neurotransmitter transport (GO:0006836)3.60621543
48regulation of neuronal synaptic plasticity (GO:0048168)3.53981288
49behavioral defense response (GO:0002209)3.53304815
50behavioral fear response (GO:0001662)3.53304815
51negative regulation of cell killing (GO:0031342)3.52676315
52negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.52676315
53neuron recognition (GO:0008038)3.51093302
54cerebellar Purkinje cell differentiation (GO:0021702)3.48615781
55exploration behavior (GO:0035640)3.48076527
56transmission of nerve impulse (GO:0019226)3.45517230
57negative regulation of dendrite morphogenesis (GO:0050774)3.39712592
58positive regulation of membrane potential (GO:0045838)3.39273363
59positive regulation of gamma-delta T cell activation (GO:0046645)3.39161039
60antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.37771044
61long-term memory (GO:0007616)3.37451454
62fear response (GO:0042596)3.34969293
63synaptic vesicle endocytosis (GO:0048488)3.33389201
64regulation of synaptic plasticity (GO:0048167)3.31315520
65negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.30134282
66astrocyte differentiation (GO:0048708)3.29266880
67microglial cell activation (GO:0001774)3.28581217
68positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.26998494
69establishment of protein localization to Golgi (GO:0072600)3.26158357
70regulation of neurotransmitter levels (GO:0001505)3.23375590
71membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.20144282
72synapse assembly (GO:0007416)3.19186821
73striatum development (GO:0021756)3.17366762
74regulation of development, heterochronic (GO:0040034)3.14775804
75membrane depolarization (GO:0051899)3.10555494
76neutrophil mediated immunity (GO:0002446)3.10143116
77regulation of synapse maturation (GO:0090128)3.10077507
78detection of molecule of bacterial origin (GO:0032490)3.08222171
79dendritic spine morphogenesis (GO:0060997)3.08113834
80regulation of neurotransmitter secretion (GO:0046928)3.07870703
81protein targeting to Golgi (GO:0000042)3.07618098
82positive regulation by symbiont of host defense response (GO:0052509)3.07546888
83modulation by symbiont of host defense response (GO:0052031)3.07546888
84modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.07546888
85modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.07546888
86positive regulation by organism of defense response of other organism involved in symbiotic interact3.07546888
87modulation by symbiont of host immune response (GO:0052553)3.07546888
88long term synaptic depression (GO:0060292)3.06376098
89synaptic transmission (GO:0007268)3.06162436
90righting reflex (GO:0060013)3.04435420
91regulation of vesicle fusion (GO:0031338)3.03543091
92intraspecies interaction between organisms (GO:0051703)3.01760085
93social behavior (GO:0035176)3.01760085
94behavioral response to cocaine (GO:0048148)3.01167236
95regulation of dendritic spine morphogenesis (GO:0061001)3.00864240
96positive regulation of muscle hypertrophy (GO:0014742)3.00766440
97positive regulation of cardiac muscle hypertrophy (GO:0010613)3.00766440
98positive regulation of cell fate commitment (GO:0010455)3.00443231
99interferon-gamma production (GO:0032609)2.98925438
100myeloid leukocyte mediated immunity (GO:0002444)2.97347741
101negative regulation of dendrite development (GO:2000171)2.96641791
102learning (GO:0007612)2.96099495
103positive regulation of synapse assembly (GO:0051965)2.95092655
104cellular response to interleukin-15 (GO:0071350)2.94942913
105negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.94354067
106regulation of glutamate secretion (GO:0014048)2.93597379
107membrane hyperpolarization (GO:0060081)2.92160099
108regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.91942008
109positive regulation of synaptic transmission (GO:0050806)2.91642358
110regulation of germinal center formation (GO:0002634)2.90078981
111negative regulation of cAMP-mediated signaling (GO:0043951)2.89570486
112axonal fasciculation (GO:0007413)2.88859135
113protein localization to cilium (GO:0061512)2.88009308
114auditory behavior (GO:0031223)2.87643594
115negative regulation of T cell mediated immunity (GO:0002710)2.87245749
116membrane depolarization during action potential (GO:0086010)2.86967732
117positive regulation of interferon-alpha production (GO:0032727)2.86844279
118mechanosensory behavior (GO:0007638)2.86016121
119regulation of interferon-beta biosynthetic process (GO:0045357)2.85012627
120detection of calcium ion (GO:0005513)2.84796580
121positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.84577570
122regulation of synaptic transmission (GO:0050804)2.83815748
123rRNA methylation (GO:0031167)2.82284973
124negative regulation of lymphocyte mediated immunity (GO:0002707)2.82029605
125regulation of synaptic transmission, GABAergic (GO:0032228)2.82018386
126positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.82012475
127regulation of cell communication by electrical coupling (GO:0010649)2.81597716
128female mating behavior (GO:0060180)2.80666236
129regulation of neurotransmitter transport (GO:0051588)2.79195758
130negative regulation of sodium ion transport (GO:0010766)2.79153243
131retrograde transport, vesicle recycling within Golgi (GO:0000301)2.78567869
132positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.77905100
133positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.77565727
134positive regulation of neurotransmitter secretion (GO:0001956)2.76875308
135response to interleukin-15 (GO:0070672)2.75706526
136cellular potassium ion homeostasis (GO:0030007)2.75699876
137regulation of female receptivity (GO:0045924)2.75481922
138negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.75368180
139regulation of dendritic spine development (GO:0060998)2.75157207
140regulation of interferon-alpha production (GO:0032647)2.68364511
141macrophage activation involved in immune response (GO:0002281)2.67596915
142behavioral response to nicotine (GO:0035095)2.67020648
143negative regulation of T-helper cell differentiation (GO:0045623)2.65300260
144negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.65300260
145negative regulation of neurotransmitter transport (GO:0051589)2.65152332
146positive T cell selection (GO:0043368)2.64349567
147regulation of memory T cell differentiation (GO:0043380)2.61645453
148negative regulation of immunoglobulin mediated immune response (GO:0002890)2.57022900
149negative regulation of B cell mediated immunity (GO:0002713)2.57022900
150regulation of gamma-delta T cell activation (GO:0046643)2.56577677
151phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.56384750
152histone H3-K9 methylation (GO:0051567)2.54257531
153negative T cell selection (GO:0043383)2.53468663
154negative regulation of cytosolic calcium ion concentration (GO:0051481)2.52922064
155DNA deamination (GO:0045006)2.52900616
156negative regulation of adaptive immune response (GO:0002820)2.52304772
157hindbrain development (GO:0030902)2.49619753
158regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.49452725
159monoubiquitinated protein deubiquitination (GO:0035520)2.48266000
160regulation of gamma-delta T cell differentiation (GO:0045586)2.47790358
161positive regulation of defense response to virus by host (GO:0002230)2.46806508
162adaptation of signaling pathway (GO:0023058)2.45275309
163cellular extravasation (GO:0045123)2.44802276
164histone H3-K9 modification (GO:0061647)2.41440707
165negative regulation of neurotransmitter secretion (GO:0046929)2.40708001
166macrophage activation (GO:0042116)2.40694591
167positive regulation of oligodendrocyte differentiation (GO:0048714)2.39458275
168neutrophil activation (GO:0042119)2.39209431
169protein localization to Golgi apparatus (GO:0034067)2.38230989
170peptidyl-lysine trimethylation (GO:0018023)2.37098048
171negative regulation of B cell proliferation (GO:0030889)2.37050858
172negative regulation of mast cell activation (GO:0033004)2.37018356
173regulation of regulatory T cell differentiation (GO:0045589)2.36709066
174gland morphogenesis (GO:0022612)2.36168744
175protein K11-linked deubiquitination (GO:0035871)2.35707270
176positive regulation of interferon-beta production (GO:0032728)2.34955673
177leukocyte migration involved in inflammatory response (GO:0002523)2.34896830
178negative thymic T cell selection (GO:0045060)2.32518250
179negative regulation of alpha-beta T cell differentiation (GO:0046639)2.29485656
180positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.29280504
181dorsal/ventral axis specification (GO:0009950)2.28911292
182RNA destabilization (GO:0050779)2.26885744
183negative regulation of translation, ncRNA-mediated (GO:0040033)2.25469330
184regulation of translation, ncRNA-mediated (GO:0045974)2.25469330
185negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.25469330
186photoreceptor cell development (GO:0042461)2.22709676
187B cell receptor signaling pathway (GO:0050853)2.21166661
188regulation of isotype switching to IgG isotypes (GO:0048302)2.21147046
189negative regulation of alpha-beta T cell activation (GO:0046636)2.18889929
190regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.17717383
191positive regulation of mast cell activation (GO:0033005)2.17319364
192regulation of mast cell activation (GO:0033003)2.17006218
193detection of external biotic stimulus (GO:0098581)2.16873509
194positive regulation of granulocyte differentiation (GO:0030854)2.16813807
195sulfation (GO:0051923)2.15668236
196glandular epithelial cell differentiation (GO:0002067)2.15089286

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.29239618
2GBX2_23144817_ChIP-Seq_PC3_Human4.47026179
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.82529903
4TAF15_26573619_Chip-Seq_HEK293_Human2.81126428
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.75682534
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.61646930
7IRF8_22096565_ChIP-ChIP_GC-B_Human2.36807532
8SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.33132960
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.31657945
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.30213015
11REST_21632747_ChIP-Seq_MESCs_Mouse2.29654543
12EZH2_18974828_ChIP-Seq_MESCs_Mouse2.27409136
13RNF2_18974828_ChIP-Seq_MESCs_Mouse2.27409136
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.25328300
15FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.23716157
16ZFP57_27257070_Chip-Seq_ESCs_Mouse2.21055983
17CTBP2_25329375_ChIP-Seq_LNCAP_Human2.14479380
18JARID2_20075857_ChIP-Seq_MESCs_Mouse2.13504567
19SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.12459018
20CTBP1_25329375_ChIP-Seq_LNCAP_Human2.11450557
21SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.11358955
22EZH2_27304074_Chip-Seq_ESCs_Mouse2.10578428
23* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.10144586
24SMAD4_21799915_ChIP-Seq_A2780_Human2.07504159
25MTF2_20144788_ChIP-Seq_MESCs_Mouse2.06857468
26SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.06382459
27SMAD_19615063_ChIP-ChIP_OVARY_Human2.04097374
28EED_16625203_ChIP-ChIP_MESCs_Mouse2.01172908
29BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.96454758
30P300_19829295_ChIP-Seq_ESCs_Human1.92026387
31IRF8_21731497_ChIP-ChIP_J774_Mouse1.91018100
32TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.86677684
33REST_18959480_ChIP-ChIP_MESCs_Mouse1.86254718
34ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.83401583
35RARB_27405468_Chip-Seq_BRAIN_Mouse1.81624322
36PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.78073710
37GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.77161801
38RNF2_27304074_Chip-Seq_ESCs_Mouse1.69685035
39BMI1_23680149_ChIP-Seq_NPCS_Mouse1.69146724
40IGF1R_20145208_ChIP-Seq_DFB_Human1.68967932
41PIAS1_25552417_ChIP-Seq_VCAP_Human1.68092637
42FUS_26573619_Chip-Seq_HEK293_Human1.67376530
43EZH2_27294783_Chip-Seq_ESCs_Mouse1.64761876
44SUZ12_27294783_Chip-Seq_ESCs_Mouse1.63394671
45RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.62889590
46RUNX_20019798_ChIP-Seq_JUKART_Human1.61536332
47IKZF1_21737484_ChIP-ChIP_HCT116_Human1.61009565
48NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.59921831
49CBX2_27304074_Chip-Seq_ESCs_Mouse1.59867719
50* FLI1_27457419_Chip-Seq_LIVER_Mouse1.58616957
51VDR_22108803_ChIP-Seq_LS180_Human1.57507683
52RNF2_27304074_Chip-Seq_NSC_Mouse1.55338649
53* STAT3_23295773_ChIP-Seq_U87_Human1.50829500
54* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.50016635
55OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.49721862
56SMAD3_21741376_ChIP-Seq_EPCs_Human1.47678088
57UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.47639763
58AR_25329375_ChIP-Seq_VCAP_Human1.47560639
59SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.45849236
60EWS_26573619_Chip-Seq_HEK293_Human1.44032918
61DROSHA_22980978_ChIP-Seq_HELA_Human1.43907813
62AR_21572438_ChIP-Seq_LNCaP_Human1.41238933
63* NANOG_18555785_Chip-Seq_ESCs_Mouse1.40799045
64CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.39565374
65SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.39520275
66FLI1_21867929_ChIP-Seq_TH2_Mouse1.38103994
67SOX2_21211035_ChIP-Seq_LN229_Gbm1.37611099
68* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.37336282
69* PCGF2_27294783_Chip-Seq_ESCs_Mouse1.36998956
70IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.36694828
71CBP_20019798_ChIP-Seq_JUKART_Human1.36694828
72IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.36242698
73AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.36068565
74PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.35774149
75FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.35482147
76* EZH2_27294783_Chip-Seq_NPCs_Mouse1.32671386
77CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.32142274
78MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.31188255
79TCF4_23295773_ChIP-Seq_U87_Human1.31069709
80STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.26827947
81E2F1_18555785_Chip-Seq_ESCs_Mouse1.25741010
82RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.25570988
83* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.24416934
84SALL1_21062744_ChIP-ChIP_HESCs_Human1.23910789
85NOTCH1_21737748_ChIP-Seq_TLL_Human1.23815664
86ARNT_22903824_ChIP-Seq_MCF-7_Human1.23139636
87MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.22570781
88MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.22499425
89CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21655827
90RUNX2_22187159_ChIP-Seq_PCA_Human1.21602722
91* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.21518426
92* NFE2_27457419_Chip-Seq_LIVER_Mouse1.21502808
93TP53_16413492_ChIP-PET_HCT116_Human1.19899494
94BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.19713560
95AHR_22903824_ChIP-Seq_MCF-7_Human1.19563398
96ER_23166858_ChIP-Seq_MCF-7_Human1.19155804
97PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.17045413
98* CMYC_18555785_Chip-Seq_ESCs_Mouse1.15381434
99BCAT_22108803_ChIP-Seq_LS180_Human1.15021369
100P53_22127205_ChIP-Seq_FIBROBLAST_Human1.14788381
101* P53_22387025_ChIP-Seq_ESCs_Mouse1.14691054
102TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.14336564
103NR3C1_23031785_ChIP-Seq_PC12_Mouse1.14165058
104* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.13851865
105CDX2_19796622_ChIP-Seq_MESCs_Mouse1.12897287
106JUN_21703547_ChIP-Seq_K562_Human1.12773098
107TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.11710826
108ZNF217_24962896_ChIP-Seq_MCF-7_Human1.11633514
109NR3C1_21868756_ChIP-Seq_MCF10A_Human1.10496954
110AR_19668381_ChIP-Seq_PC3_Human1.08810713
111IRF1_19129219_ChIP-ChIP_H3396_Human1.08227734
112RXR_22108803_ChIP-Seq_LS180_Human1.07565824
113EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.07321200
114* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.06965671
115PRDM14_20953172_ChIP-Seq_ESCs_Human1.06760768
116TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.06251596
117VDR_24787735_ChIP-Seq_THP-1_Human1.05688309
118GATA3_26560356_Chip-Seq_TH2_Human1.05619114
119TP53_22573176_ChIP-Seq_HFKS_Human1.04969326
120IRF8_27001747_Chip-Seq_BMDM_Mouse1.04616481
121* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.04586488
122* OCT4_21477851_ChIP-Seq_ESCs_Mouse1.04200218
123ZNF274_21170338_ChIP-Seq_K562_Hela1.03652380
124* PCGF2_27294783_Chip-Seq_NPCs_Mouse1.02707176
125POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.02599525
126TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02599525
127* P300_18555785_Chip-Seq_ESCs_Mouse1.02438478
128* SOX2_18555785_Chip-Seq_ESCs_Mouse1.02396588
129SMAD4_21741376_ChIP-Seq_EPCs_Human1.01603079
130KDM2B_26808549_Chip-Seq_REH_Human1.01300283
131* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.01112745
132RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.00276760
133* CRX_20693478_ChIP-Seq_RETINA_Mouse1.00063696
134* STAT3_18555785_Chip-Seq_ESCs_Mouse0.99533730
135TCF4_22108803_ChIP-Seq_LS180_Human0.99469604
136PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99330700
137SOX2_19829295_ChIP-Seq_ESCs_Human0.98570678
138NANOG_19829295_ChIP-Seq_ESCs_Human0.98570678

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.21825900
2MP0004859_abnormal_synaptic_plasticity5.03586006
3MP0003635_abnormal_synaptic_transmissio3.76206746
4MP0000569_abnormal_digit_pigmentation3.57033006
5MP0003724_increased_susceptibility_to3.43027615
6MP0009745_abnormal_behavioral_response3.40382861
7MP0009046_muscle_twitch3.32594229
8MP0002064_seizures3.10714703
9MP0002063_abnormal_learning/memory/cond3.08229966
10MP0001968_abnormal_touch/_nociception3.05266479
11MP0004270_analgesia3.04502123
12MP0002572_abnormal_emotion/affect_behav2.84994717
13MP0001501_abnormal_sleep_pattern2.75583437
14MP0002272_abnormal_nervous_system2.70001778
15MP0002822_catalepsy2.62055513
16MP0002735_abnormal_chemical_nociception2.57220560
17MP0001486_abnormal_startle_reflex2.55702855
18MP0002736_abnormal_nociception_after2.53657833
19MP0002734_abnormal_mechanical_nocicepti2.44791316
20MP0001440_abnormal_grooming_behavior2.22704580
21MP0002876_abnormal_thyroid_physiology2.19231146
22MP0002067_abnormal_sensory_capabilities2.16572005
23MP0001188_hyperpigmentation2.13768822
24MP0005423_abnormal_somatic_nervous2.05195067
25MP0006276_abnormal_autonomic_nervous2.01403996
26MP0008789_abnormal_olfactory_epithelium2.00880275
27MP0005646_abnormal_pituitary_gland1.99566827
28MP0001984_abnormal_olfaction1.92133771
29MP0008057_abnormal_DNA_replication1.87084997
30MP0005386_behavior/neurological_phenoty1.81125467
31MP0004924_abnormal_behavior1.81125467
32MP0002733_abnormal_thermal_nociception1.81082327
33MP0001970_abnormal_pain_threshold1.77410835
34MP0005671_abnormal_response_to1.76373325
35MP0002102_abnormal_ear_morphology1.75471931
36MP0003787_abnormal_imprinting1.69562903
37MP0005257_abnormal_intraocular_pressure1.68279645
38MP0001835_abnormal_antigen_presentation1.67728003
39MP0002184_abnormal_innervation1.64252509
40MP0005551_abnormal_eye_electrophysiolog1.56716190
41MP0001800_abnormal_humoral_immune1.56164024
42MP0002557_abnormal_social/conspecific_i1.54326330
43MP0000778_abnormal_nervous_system1.53618908
44MP0003121_genomic_imprinting1.53037560
45MP0003879_abnormal_hair_cell1.52037024
46MP0004142_abnormal_muscle_tone1.47985589
47MP0002837_dystrophic_cardiac_calcinosis1.46938584
48MP0009780_abnormal_chondrocyte_physiolo1.46528389
49MP0001919_abnormal_reproductive_system1.45949714
50MP0005645_abnormal_hypothalamus_physiol1.44951261
51MP0008569_lethality_at_weaning1.44860024
52MP0006292_abnormal_olfactory_placode1.43888975
53MP0001529_abnormal_vocalization1.43751072
54MP0002160_abnormal_reproductive_system1.36086619
55MP0003195_calcinosis1.35574067
56MP0008872_abnormal_physiological_respon1.31963593
57MP0002909_abnormal_adrenal_gland1.30283084
58MP0004858_abnormal_nervous_system1.27882610
59MP0002066_abnormal_motor_capabilities/c1.26447728
60MP0005389_reproductive_system_phenotype1.24527561
61MP0001905_abnormal_dopamine_level1.23855504
62MP0010386_abnormal_urinary_bladder1.23821253
63MP0000955_abnormal_spinal_cord1.21479825
64MP0003329_amyloid_beta_deposits1.21261379
65MP0002882_abnormal_neuron_morphology1.21235506
66MP0002723_abnormal_immune_serum1.20511626
67MP0003633_abnormal_nervous_system1.20126774
68MP0003646_muscle_fatigue1.19197479
69MP0001502_abnormal_circadian_rhythm1.18612704
70MP0005535_abnormal_body_temperature1.18563485
71MP0004811_abnormal_neuron_physiology1.15789201
72MP0002277_abnormal_respiratory_mucosa1.15244045
73MP0002420_abnormal_adaptive_immunity1.13885153
74MP0002928_abnormal_bile_duct1.11866468
75MP0008875_abnormal_xenobiotic_pharmacok1.11805382
76MP0000613_abnormal_salivary_gland1.11744242
77MP0001819_abnormal_immune_cell1.11472236
78MP0005174_abnormal_tail_pigmentation1.10540281
79MP0005000_abnormal_immune_tolerance1.08921046
80MP0009785_altered_susceptibility_to1.08698951
81MP0005310_abnormal_salivary_gland1.06956967
82MP0003122_maternal_imprinting1.06589540
83MP0002638_abnormal_pupillary_reflex1.05432382
84MP0002229_neurodegeneration1.04635014
85MP0002452_abnormal_antigen_presenting1.03649974
86MP0001485_abnormal_pinna_reflex1.02705687
87MP0001177_atelectasis1.01358328
88MP0001963_abnormal_hearing_physiology1.01149714
89MP0005025_abnormal_response_to1.00562396
90MP0003631_nervous_system_phenotype0.99505687
91MP0004885_abnormal_endolymph0.99007665
92MP0004742_abnormal_vestibular_system0.98952149
93MP0002419_abnormal_innate_immunity0.98442090
94MP0000383_abnormal_hair_follicle0.98340887
95MP0005394_taste/olfaction_phenotype0.96315851
96MP0005499_abnormal_olfactory_system0.96315851
97MP0001790_abnormal_immune_system0.95325400
98MP0005387_immune_system_phenotype0.95325400
99MP0000013_abnormal_adipose_tissue0.94660022
100MP0008874_decreased_physiological_sensi0.94596765
101MP0000685_abnormal_immune_system0.94366152
102MP0000427_abnormal_hair_cycle0.94202979
103MP0002693_abnormal_pancreas_physiology0.92803553
104MP0002938_white_spotting0.91986477
105MP0004043_abnormal_pH_regulation0.91618266
106MP0000465_gastrointestinal_hemorrhage0.91298282
107MP0003763_abnormal_thymus_physiology0.91222344
108MP0004381_abnormal_hair_follicle0.89925583
109MP0009764_decreased_sensitivity_to0.88183818
110MP0003252_abnormal_bile_duct0.87985083
111MP0002332_abnormal_exercise_endurance0.87056706
112MP0002405_respiratory_system_inflammati0.86608167
113MP0002752_abnormal_somatic_nervous0.85742334
114MP0005379_endocrine/exocrine_gland_phen0.85608128
115MP0008995_early_reproductive_senescence0.85482019
116MP0002069_abnormal_eating/drinking_beha0.85382624
117MP0000631_abnormal_neuroendocrine_gland0.84768001
118MP0003303_peritoneal_inflammation0.84312084
119MP0002152_abnormal_brain_morphology0.84283780
120MP0000716_abnormal_immune_system0.83128244
121MP0000015_abnormal_ear_pigmentation0.81388266
122MP0003866_abnormal_defecation0.80477569
123MP0003436_decreased_susceptibility_to0.80042489
124MP0002398_abnormal_bone_marrow0.77639855
125MP0004484_altered_response_of0.77167383
126MP0006035_abnormal_mitochondrial_morpho0.76895684
127MP0005084_abnormal_gallbladder_morpholo0.76341435
128MP0004085_abnormal_heartbeat0.76321260
129MP0010678_abnormal_skin_adnexa0.75860641
130MP0002090_abnormal_vision0.73915791
131MP0008877_abnormal_DNA_methylation0.73340737
132MP0002138_abnormal_hepatobiliary_system0.73176607
133MP0003183_abnormal_peptide_metabolism0.72908521
134MP0004215_abnormal_myocardial_fiber0.72873002
135MP0000689_abnormal_spleen_morphology0.71995538
136MP0005670_abnormal_white_adipose0.69622923
137MP0005171_absent_coat_pigmentation0.67655740
138MP0005253_abnormal_eye_physiology0.67370594
139MP0003632_abnormal_nervous_system0.65695029
140MP0005409_darkened_coat_color0.64335007
141MP0000026_abnormal_inner_ear0.62110582
142MP0001986_abnormal_taste_sensitivity0.61500513
143MP0004145_abnormal_muscle_electrophysio0.61308047
144MP0002254_reproductive_system_inflammat0.58411090
145MP0001664_abnormal_digestion0.55219792
146MP0006072_abnormal_retinal_apoptosis0.55167210
147MP0003690_abnormal_glial_cell0.54943757
148MP0003011_delayed_dark_adaptation0.53129148
149MP0004130_abnormal_muscle_cell0.51650589
150MP0000230_abnormal_systemic_arterial0.51308134
151MP0005448_abnormal_energy_balance0.51211512
152MP0010234_abnormal_vibrissa_follicle0.47375661
153MP0002078_abnormal_glucose_homeostasis0.47368825

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)9.08243968
2Febrile seizures (HP:0002373)6.45617540
3Hyperventilation (HP:0002883)6.19074818
4Epileptic encephalopathy (HP:0200134)6.07298077
5Atonic seizures (HP:0010819)5.84205054
6Focal seizures (HP:0007359)5.65822467
7Hypoplasia of the fovea (HP:0007750)4.65007898
8Aplasia/Hypoplasia of the fovea (HP:0008060)4.65007898
9Absence seizures (HP:0002121)4.57112291
10Dialeptic seizures (HP:0011146)4.35026005
11Myokymia (HP:0002411)4.34465826
12Generalized tonic-clonic seizures (HP:0002069)4.16962243
13Abnormality of the fovea (HP:0000493)3.86618466
14Broad-based gait (HP:0002136)3.80716884
15Visual hallucinations (HP:0002367)3.79858143
16Progressive cerebellar ataxia (HP:0002073)3.79323404
17Retrobulbar optic neuritis (HP:0100654)3.63465880
18Optic neuritis (HP:0100653)3.63465880
19Aplasia/Hypoplasia of the macula (HP:0008059)3.54242951
20Protruding tongue (HP:0010808)3.41766072
21Gaze-evoked nystagmus (HP:0000640)3.35852053
22Excessive salivation (HP:0003781)3.35368066
23Drooling (HP:0002307)3.35368066
24Amblyopia (HP:0000646)3.35359791
25Absent speech (HP:0001344)3.30448606
26Stomatitis (HP:0010280)3.26486517
27Aplasia/Hypoplasia affecting the retina (HP:0008061)3.23883233
28Poor eye contact (HP:0000817)3.22885003
29Inability to walk (HP:0002540)3.20335033
30Orchitis (HP:0100796)3.04250821
31Generalized hypopigmentation of hair (HP:0011358)3.03927194
32Impaired social interactions (HP:0000735)3.00478750
33Abnormal social behavior (HP:0012433)3.00478750
34Myositis (HP:0100614)2.97571601
35Keratoconjunctivitis (HP:0001096)2.87328087
36Dysdiadochokinesis (HP:0002075)2.84748155
37Status epilepticus (HP:0002133)2.84117900
38Keratitis (HP:0000491)2.83654475
39Abnormality of the lower motor neuron (HP:0002366)2.83034203
40Absent rod-and cone-mediated responses on ERG (HP:0007688)2.79490417
41Fair hair (HP:0002286)2.78191573
42Pancreatic cysts (HP:0001737)2.74964838
43Abnormality of T cell number (HP:0011839)2.71957509
44Keratoconjunctivitis sicca (HP:0001097)2.69285638
45Volvulus (HP:0002580)2.66697111
46Truncal ataxia (HP:0002078)2.66196474
47Epileptiform EEG discharges (HP:0011182)2.65271084
48Blue irides (HP:0000635)2.61112865
49Impaired vibration sensation in the lower limbs (HP:0002166)2.58027102
50Fetal akinesia sequence (HP:0001989)2.56499126
51Difficulty running (HP:0009046)2.55237094
52T lymphocytopenia (HP:0005403)2.51987476
53Scanning speech (HP:0002168)2.51819522
54Optic nerve hypoplasia (HP:0000609)2.51548834
55Thyroiditis (HP:0100646)2.51405326
56Abnormal rod and cone electroretinograms (HP:0008323)2.49302899
57True hermaphroditism (HP:0010459)2.48441386
58Dysmetria (HP:0001310)2.47674249
59Limb dystonia (HP:0002451)2.47474589
60Abnormal eating behavior (HP:0100738)2.45307894
61Neoplasm of the tracheobronchial system (HP:0100552)2.44461009
62Stomach cancer (HP:0012126)2.42894401
63Progressive inability to walk (HP:0002505)2.41007438
64Action tremor (HP:0002345)2.39972251
65EEG with generalized epileptiform discharges (HP:0011198)2.39759003
66Generalized myoclonic seizures (HP:0002123)2.38683407
67Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.35056657
68Gastrointestinal infarctions (HP:0005244)2.33726924
69Elevated erythrocyte sedimentation rate (HP:0003565)2.32549219
70Abnormal delayed hypersensitivity skin test (HP:0002963)2.31752461
71Hemiparesis (HP:0001269)2.30120063
72Abnormality of eosinophils (HP:0001879)2.29896971
73Recurrent fungal infections (HP:0002841)2.27298663
74Abnormality of the renal cortex (HP:0011035)2.25078104
75Pancreatic fibrosis (HP:0100732)2.23485093
76Encephalitis (HP:0002383)2.22946892
77Recurrent bacterial skin infections (HP:0005406)2.22919959
78Impaired smooth pursuit (HP:0007772)2.21689257
79Hyperthyroidism (HP:0000836)2.19178392
80Abnormality of salivation (HP:0100755)2.19019763
81Gait imbalance (HP:0002141)2.18649654
82Anxiety (HP:0000739)2.18538226
83Attenuation of retinal blood vessels (HP:0007843)2.17263721
84Horizontal nystagmus (HP:0000666)2.17011954
85Urinary bladder sphincter dysfunction (HP:0002839)2.16002255
86Optic nerve coloboma (HP:0000588)2.14115256
87Abnormal hair whorl (HP:0010721)2.13746186
88Hypsarrhythmia (HP:0002521)2.13477685
89Eczematoid dermatitis (HP:0000976)2.13208245
90Decreased central vision (HP:0007663)2.12233448
91Papillary thyroid carcinoma (HP:0002895)2.10963554
92Impaired vibratory sensation (HP:0002495)2.09468142
93Polyphagia (HP:0002591)2.08169921
94Hip dysplasia (HP:0001385)2.07887471
95Sensory axonal neuropathy (HP:0003390)2.07015511
96Recurrent cutaneous fungal infections (HP:0011370)2.06726047
97Chronic mucocutaneous candidiasis (HP:0002728)2.06726047
98Supranuclear gaze palsy (HP:0000605)2.02463093
99Oligomenorrhea (HP:0000876)2.01973854
100Hemiplegia (HP:0002301)2.01714134
101Leukocytosis (HP:0001974)2.01703872
102Depression (HP:0000716)1.99954732
103Abnormality of ocular smooth pursuit (HP:0000617)1.99549603
104Bradykinesia (HP:0002067)1.99080813
105Abnormality of the corticospinal tract (HP:0002492)1.98871241
106Medial flaring of the eyebrow (HP:0010747)1.98277411
107Congenital primary aphakia (HP:0007707)1.97823550
108Hypochromic anemia (HP:0001931)1.97159565
109Hemoptysis (HP:0002105)1.96206297
110Abnormality of T cells (HP:0002843)1.94821141
111Recurrent abscess formation (HP:0002722)1.94738854
112Hypochromic microcytic anemia (HP:0004840)1.92933214
113Abnormal ciliary motility (HP:0012262)1.92040085
114Mediastinal lymphadenopathy (HP:0100721)1.91642243
115Abolished electroretinogram (ERG) (HP:0000550)1.90209164
116Postural instability (HP:0002172)1.90162719
117Papilledema (HP:0001085)1.88662508
118Molar tooth sign on MRI (HP:0002419)1.87062055
119Abnormality of midbrain morphology (HP:0002418)1.87062055
120Aqueductal stenosis (HP:0002410)1.85480040
121Failure to thrive in infancy (HP:0001531)1.85156200
122Short 1st metacarpal (HP:0010034)1.85074680
123Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.85074680
124Eosinophilia (HP:0001880)1.84605357
125Spastic gait (HP:0002064)1.84106431
126Nephronophthisis (HP:0000090)1.83723443
127Nephrogenic diabetes insipidus (HP:0009806)1.82515711
128Exotropia (HP:0000577)1.82470476
129Abnormality of the labia minora (HP:0012880)1.82133633
130Abnormality of the renal medulla (HP:0100957)1.81539592
131Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.81001286
132Widely spaced teeth (HP:0000687)1.80940703
133Intention tremor (HP:0002080)1.80540563
134Degeneration of the lateral corticospinal tracts (HP:0002314)1.79685366
135Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.79685366
136Poor suck (HP:0002033)1.78889567
137Chronic hepatic failure (HP:0100626)1.78219411
138Dynein arm defect of respiratory motile cilia (HP:0012255)1.78013508
139Absent/shortened dynein arms (HP:0200106)1.78013508
140Genetic anticipation (HP:0003743)1.77578358
141Intellectual disability, severe (HP:0010864)1.76968491
142Severe combined immunodeficiency (HP:0004430)1.76540164
143Pheochromocytoma (HP:0002666)1.76413468
144Dysmetric saccades (HP:0000641)1.76266093
145Gait ataxia (HP:0002066)1.76218908
146Vasculitis (HP:0002633)1.75658188
147Congenital stationary night blindness (HP:0007642)1.75560908
148Deeply set eye (HP:0000490)1.75472813
149IgG deficiency (HP:0004315)1.73251526
150Stereotypic behavior (HP:0000733)1.72848575
151Intellectual disability, progressive (HP:0006887)1.72811268
152Metabolic alkalosis (HP:0200114)1.72718087
153Esotropia (HP:0000565)1.72696419
154Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.72209425
155Resting tremor (HP:0002322)1.70760855
156Abnormal respiratory motile cilium physiology (HP:0012261)1.70448369
157Dyskinesia (HP:0100660)1.70236064
158Intestinal atresia (HP:0011100)1.69723336
159Congenital sensorineural hearing impairment (HP:0008527)1.69577766
160Decreased circulating renin level (HP:0003351)1.69407365
161Recurrent skin infections (HP:0001581)1.69073866
162Mask-like facies (HP:0000298)1.68783752
163Specific learning disability (HP:0001328)1.68016203
164Pulmonary infiltrates (HP:0002113)1.66364358
165Renal cortical cysts (HP:0000803)1.65850453
166Meningitis (HP:0001287)1.65003268
167Termporal pattern (HP:0011008)1.64018719
168Insidious onset (HP:0003587)1.64018719
169Pulmonary embolism (HP:0002204)1.63131471
170Bradycardia (HP:0001662)1.62390580
171Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.60841585
172Abnormality of macular pigmentation (HP:0008002)1.60619214
173Genital tract atresia (HP:0001827)1.60359668
174Diplopia (HP:0000651)1.59906934
175Abnormality of binocular vision (HP:0011514)1.59906934
176Central scotoma (HP:0000603)1.59835411
177Thickened helices (HP:0000391)1.59353541
178Gastroesophageal reflux (HP:0002020)1.58453633
179Cerebral inclusion bodies (HP:0100314)1.57718839

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.47254559
2BRD44.30299260
3NTRK34.14682234
4EPHA43.92355870
5MAP3K42.99958795
6MAP3K122.96508825
7TAOK32.80094529
8MAP2K72.69032672
9MAP3K132.67890573
10MAP3K92.40345716
11MAP2K42.24671514
12AKT32.17795834
13GRK52.14437944
14TXK2.07283666
15RIPK42.06781224
16ACVR1B1.98115167
17MINK11.80673762
18DAPK21.73763293
19PLK21.73675419
20TNIK1.63987501
21HIPK21.62140469
22PRPF4B1.57169266
23MARK11.50792806
24FRK1.50578169
25SGK21.44267279
26NTRK11.41862882
27BLK1.30254687
28NTRK21.29708334
29BMPR1B1.28417208
30CCNB11.27853986
31PNCK1.27707765
32MAP4K21.27418489
33IRAK11.23196378
34DAPK11.22826318
35CSK1.19492861
36MAPK131.19014064
37IRAK21.17683331
38MKNK21.16999936
39CDK191.15530204
40SGK4941.14451957
41SGK2231.14451957
42TEC1.13752649
43PAK61.13579345
44OXSR11.13326474
45BMPR21.12696844
46ITK1.12599740
47KSR11.12282486
48SYK1.11255495
49PAK31.10333196
50CAMKK21.08716377
51PRKCG1.04536640
52CAMK2A1.03651013
53IKBKE1.03257882
54IRAK41.02410000
55MAP4K11.01995121
56GRK11.01422369
57CDK51.00771696
58KSR21.00120815
59BTK0.98949648
60GRK70.98908568
61YES10.93888199
62ADRBK20.93423514
63STK380.91242400
64SGK30.90300161
65NUAK10.88942083
66EPHA30.84986428
67MAP3K60.84283802
68ARAF0.83756410
69LATS20.80886217
70ERBB40.80779331
71HCK0.80644905
72FES0.79688560
73TNK20.77778877
74SGK10.77571802
75LYN0.77305237
76MUSK0.74242283
77PIK3CA0.73608186
78INSRR0.73526772
79PIK3CG0.73390843
80CAMK2B0.73087619
81CAMKK10.71546407
82JAK20.69049658
83DYRK1A0.68916741
84FGR0.68884880
85CAMK2D0.67899388
86SIK30.66787874
87SIK20.66049967
88PINK10.65508977
89LCK0.64593653
90CAMK10.63280423
91MARK20.62426227
92NLK0.62422020
93PRKCQ0.61992463
94ERBB30.61755358
95PRKCE0.61504172
96KIT0.61116316
97STK110.60055269
98TAOK10.59524651
99MAP3K70.58691354
100BRAF0.58275550
101MAP2K60.57899312
102FGFR20.56272760
103BCR0.56055592
104MATK0.54541212
105DYRK30.54431302
106MAPK70.54230049
107TRIM280.54209855
108MAP3K20.54124794
109CDK30.53709058
110WNK10.53332360
111NEK90.52895178
112BCKDK0.52630141
113ADRBK10.52266596
114JAK10.50084998
115JAK30.48870361
116GRK60.48024487
117RAF10.47115332
118MAPK100.46499673
119PDK10.45633161
120IKBKB0.45596908
121TLK10.45532684
122MAP3K140.43393213
123PDPK10.42179933
124CDK180.41839322
125TYRO30.41644202
126PTK2B0.41330802
127CSNK1G20.41054253
128CAMK1G0.40388775
129CAMK40.40345322
130RPS6KA30.39621445
131CDK140.39190174
132WNK30.38863168
133PKN10.37627426
134PRKACA0.37212563
135CDK90.37054089
136CAMK2G0.36178299
137PDK30.35792472
138PDK40.35792472
139MAPK120.35450636
140CDK150.35367027
141NME10.33632025
142PRKCZ0.32670362
143MAP3K10.31512869
144RPS6KB10.31156226

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.65787104
2Synaptic vesicle cycle_Homo sapiens_hsa047213.20540190
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.97532160
4GABAergic synapse_Homo sapiens_hsa047272.85721110
5Long-term potentiation_Homo sapiens_hsa047202.74568671
6Glutamatergic synapse_Homo sapiens_hsa047242.68880382
7Olfactory transduction_Homo sapiens_hsa047402.63402562
8Morphine addiction_Homo sapiens_hsa050322.59885587
9Circadian entrainment_Homo sapiens_hsa047132.55008462
10Amphetamine addiction_Homo sapiens_hsa050312.46362913
11Taste transduction_Homo sapiens_hsa047422.25244273
12Maturity onset diabetes of the young_Homo sapiens_hsa049502.21294549
13Caffeine metabolism_Homo sapiens_hsa002322.17807903
14Dopaminergic synapse_Homo sapiens_hsa047282.01613251
15Salivary secretion_Homo sapiens_hsa049702.00480928
16Collecting duct acid secretion_Homo sapiens_hsa049662.00237532
17Long-term depression_Homo sapiens_hsa047301.94161086
18Serotonergic synapse_Homo sapiens_hsa047261.93929730
19Insulin secretion_Homo sapiens_hsa049111.81574921
20Renin secretion_Homo sapiens_hsa049241.72770896
21Calcium signaling pathway_Homo sapiens_hsa040201.65117415
22Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.62161318
23Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.61001229
24Cholinergic synapse_Homo sapiens_hsa047251.58196893
25Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.56458342
26Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.53795022
27Phototransduction_Homo sapiens_hsa047441.53139054
28Gastric acid secretion_Homo sapiens_hsa049711.49605330
29NOD-like receptor signaling pathway_Homo sapiens_hsa046211.48748343
30Aldosterone synthesis and secretion_Homo sapiens_hsa049251.47921232
31Oxytocin signaling pathway_Homo sapiens_hsa049211.45586946
32Graft-versus-host disease_Homo sapiens_hsa053321.45434222
33Primary immunodeficiency_Homo sapiens_hsa053401.42602768
34T cell receptor signaling pathway_Homo sapiens_hsa046601.35887896
35Cocaine addiction_Homo sapiens_hsa050301.33148086
36GnRH signaling pathway_Homo sapiens_hsa049121.31400753
37Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.30788356
38Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.25117742
39Leishmaniasis_Homo sapiens_hsa051401.24936762
40RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.24933534
41Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.23991225
42Osteoclast differentiation_Homo sapiens_hsa043801.23487288
43Intestinal immune network for IgA production_Homo sapiens_hsa046721.22351632
44Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.20810443
45cAMP signaling pathway_Homo sapiens_hsa040241.20001942
46Allograft rejection_Homo sapiens_hsa053301.17754480
47B cell receptor signaling pathway_Homo sapiens_hsa046621.14787244
48Staphylococcus aureus infection_Homo sapiens_hsa051501.11974284
49Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.11132643
50Autoimmune thyroid disease_Homo sapiens_hsa053201.11063702
51Linoleic acid metabolism_Homo sapiens_hsa005911.09639727
52Chemokine signaling pathway_Homo sapiens_hsa040621.07276467
53Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.07120044
54Measles_Homo sapiens_hsa051621.06985058
55Jak-STAT signaling pathway_Homo sapiens_hsa046301.05235710
56Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.04225811
57Tuberculosis_Homo sapiens_hsa051521.03370479
58Vibrio cholerae infection_Homo sapiens_hsa051101.01658033
59Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.01190306
60alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.00295032
61Phosphatidylinositol signaling system_Homo sapiens_hsa040700.99990161
62Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.98301301
63NF-kappa B signaling pathway_Homo sapiens_hsa040640.96850007
64Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.89653565
65Hematopoietic cell lineage_Homo sapiens_hsa046400.88120327
66Type II diabetes mellitus_Homo sapiens_hsa049300.86584591
67Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.86570319
68Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.85288199
69Vascular smooth muscle contraction_Homo sapiens_hsa042700.85252033
70Gap junction_Homo sapiens_hsa045400.84066921
71cGMP-PKG signaling pathway_Homo sapiens_hsa040220.82078879
72ABC transporters_Homo sapiens_hsa020100.80256173
73Toll-like receptor signaling pathway_Homo sapiens_hsa046200.78962045
74Glioma_Homo sapiens_hsa052140.78223128
75ErbB signaling pathway_Homo sapiens_hsa040120.77944875
76Prolactin signaling pathway_Homo sapiens_hsa049170.77375201
77Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.76788165
78Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.75806348
79Asthma_Homo sapiens_hsa053100.75397173
80Melanogenesis_Homo sapiens_hsa049160.74841530
81FoxO signaling pathway_Homo sapiens_hsa040680.73996863
82Glucagon signaling pathway_Homo sapiens_hsa049220.73915094
83Vitamin B6 metabolism_Homo sapiens_hsa007500.72814878
84Malaria_Homo sapiens_hsa051440.72793449
85Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.71243370
86Ovarian steroidogenesis_Homo sapiens_hsa049130.70226245
87Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.69348502
88Cardiac muscle contraction_Homo sapiens_hsa042600.69245149
89Estrogen signaling pathway_Homo sapiens_hsa049150.68034288
90Oxidative phosphorylation_Homo sapiens_hsa001900.67763765
91Platelet activation_Homo sapiens_hsa046110.66705952
92Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.66278070
93Circadian rhythm_Homo sapiens_hsa047100.66094157
94Fatty acid biosynthesis_Homo sapiens_hsa000610.64625881
95Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.64373859
96Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.64369491
97Oocyte meiosis_Homo sapiens_hsa041140.64143549
98Butanoate metabolism_Homo sapiens_hsa006500.63701036
99Legionellosis_Homo sapiens_hsa051340.62336107
100Axon guidance_Homo sapiens_hsa043600.61414307
101Choline metabolism in cancer_Homo sapiens_hsa052310.61174777
102Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.61115141
103Phospholipase D signaling pathway_Homo sapiens_hsa040720.60482722
104Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.60037728
105Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.59829032
106Pancreatic secretion_Homo sapiens_hsa049720.58705069
107Dorso-ventral axis formation_Homo sapiens_hsa043200.58585342
108TNF signaling pathway_Homo sapiens_hsa046680.56210903
109Alzheimers disease_Homo sapiens_hsa050100.55908879
110Inositol phosphate metabolism_Homo sapiens_hsa005620.54557770
111Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.54338819
112Thyroid hormone synthesis_Homo sapiens_hsa049180.53667045
113MAPK signaling pathway_Homo sapiens_hsa040100.53072014
114Glycerophospholipid metabolism_Homo sapiens_hsa005640.51654008
115Basal transcription factors_Homo sapiens_hsa030220.49557944
116Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.49005855
117Steroid hormone biosynthesis_Homo sapiens_hsa001400.48491632
118Ras signaling pathway_Homo sapiens_hsa040140.46869817
119Bile secretion_Homo sapiens_hsa049760.46446323
120African trypanosomiasis_Homo sapiens_hsa051430.45218147
121Type I diabetes mellitus_Homo sapiens_hsa049400.45124201
122Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.43195765
123Arginine biosynthesis_Homo sapiens_hsa002200.41624059
124Glycerolipid metabolism_Homo sapiens_hsa005610.36895606
125Propanoate metabolism_Homo sapiens_hsa006400.34088194
126Ether lipid metabolism_Homo sapiens_hsa005650.33646934
127Rheumatoid arthritis_Homo sapiens_hsa053230.32719399
128Huntingtons disease_Homo sapiens_hsa050160.29146159
129Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.28246120
130SNARE interactions in vesicular transport_Homo sapiens_hsa041300.26623775
131Dilated cardiomyopathy_Homo sapiens_hsa054140.26459681
132mTOR signaling pathway_Homo sapiens_hsa041500.26275233
133Nitrogen metabolism_Homo sapiens_hsa009100.25807256
134Carbohydrate digestion and absorption_Homo sapiens_hsa049730.25478916
135Sphingolipid signaling pathway_Homo sapiens_hsa040710.24979214
136Rap1 signaling pathway_Homo sapiens_hsa040150.24883128
137Pyruvate metabolism_Homo sapiens_hsa006200.24479123
138Insulin signaling pathway_Homo sapiens_hsa049100.23940115
139Longevity regulating pathway - mammal_Homo sapiens_hsa042110.23440078
140PPAR signaling pathway_Homo sapiens_hsa033200.22779688
141Regulation of autophagy_Homo sapiens_hsa041400.19263793
142Melanoma_Homo sapiens_hsa052180.19174561
143beta-Alanine metabolism_Homo sapiens_hsa004100.19127102

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