ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	synaptic vesicle docking involved in exocytosis (GO:0016081)	4.96012608
2	synaptic vesicle maturation (GO:0016188)	4.90812534
3	glutamate secretion (GO:0014047)	4.76056285
4	regulation of short-term neuronal synaptic plasticity (GO:0048172)	4.36002386
5	synaptic vesicle exocytosis (GO:0016079)	4.18320273
6	postsynaptic membrane organization (GO:0001941)	3.81593881
7	regulation of synaptic vesicle exocytosis (GO:2000300)	3.71688300
8	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	3.59240577
9	negative regulation of synaptic transmission, GABAergic (GO:0032229)	3.50865687
10	axonal fasciculation (GO:0007413)	3.46018696
11	neuronal ion channel clustering (GO:0045161)	3.41109070
12	regulation of synapse structural plasticity (GO:0051823)	3.40558148
13	cellular potassium ion homeostasis (GO:0030007)	3.40398593
14	pyrimidine nucleobase catabolic process (GO:0006208)	3.40150282
15	locomotory exploration behavior (GO:0035641)	3.37437947
16	establishment of mitochondrion localization (GO:0051654)	3.35132207
17	sodium ion export (GO:0071436)	3.32150035
18	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act	3.27987867
19	dendritic spine morphogenesis (GO:0060997)	3.27746182
20	cell migration in hindbrain (GO:0021535)	3.27001850
21	neuron recognition (GO:0008038)	3.26562649
22	regulation of synaptic vesicle transport (GO:1902803)	3.26179103
23	protein localization to synapse (GO:0035418)	3.24275881
24	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	3.22535731
25	axon extension (GO:0048675)	3.07204754
26	cell communication by electrical coupling (GO:0010644)	3.04893410
27	neurotransmitter secretion (GO:0007269)	3.03429910
28	cell communication by electrical coupling involved in cardiac conduction (GO:0086064)	3.02595285
29	neuronal action potential propagation (GO:0019227)	3.00496062
30	positive regulation of excitatory postsynaptic membrane potential (GO:2000463)	2.99672092
31	exploration behavior (GO:0035640)	2.97696398
32	protein retention in ER lumen (GO:0006621)	2.95618170
33	layer formation in cerebral cortex (GO:0021819)	2.92445728
34	regulation of neuronal synaptic plasticity (GO:0048168)	2.92364523
35	response to gravity (GO:0009629)	2.91782526
36	vocalization behavior (GO:0071625)	2.89679826
37	cerebellar Purkinje cell layer development (GO:0021680)	2.78460548
38	central nervous system myelination (GO:0022010)	2.78327355
39	axon ensheathment in central nervous system (GO:0032291)	2.78327355
40	positive regulation of synapse assembly (GO:0051965)	2.78231864
41	auditory behavior (GO:0031223)	2.77918148
42	synaptic vesicle endocytosis (GO:0048488)	2.77237251
43	neuron cell-cell adhesion (GO:0007158)	2.76798184
44	dendritic spine organization (GO:0097061)	2.73853642
45	cerebellar granule cell differentiation (GO:0021707)	2.72313325
46	protein heterotrimerization (GO:0070208)	2.70346861
47	regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)	2.70246350
48	extracellular fibril organization (GO:0043206)	2.69609084
49	establishment of mitochondrion localization, microtubule-mediated (GO:0034643)	2.68354208
50	mitochondrion transport along microtubule (GO:0047497)	2.68354208
51	neuron projection extension (GO:1990138)	2.67924827
52	nucleobase catabolic process (GO:0046113)	2.65156639
53	type B pancreatic cell proliferation (GO:0044342)	2.64935113
54	presynaptic membrane organization (GO:0097090)	2.64429623
55	synaptic transmission, glutamatergic (GO:0035249)	2.63529119
56	regulation of respiratory gaseous exchange by neurological system process (GO:0002087)	2.63524231
57	neuromuscular synaptic transmission (GO:0007274)	2.59971974
58	positive regulation of synapse maturation (GO:0090129)	2.59933048
59	kidney mesenchyme development (GO:0072074)	2.55596799
60	maintenance of protein localization in endoplasmic reticulum (GO:0035437)	2.55219437
61	regulation of long-term neuronal synaptic plasticity (GO:0048169)	2.54376844
62	regulation of glutamate receptor signaling pathway (GO:1900449)	2.52495911
63	response to auditory stimulus (GO:0010996)	2.50564444
64	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	2.49677529
65	regulation of neurotransmitter secretion (GO:0046928)	2.47113489
66	neurotransmitter-gated ion channel clustering (GO:0072578)	2.46101190
67	positive regulation of potassium ion transmembrane transporter activity (GO:1901018)	2.45804827
68	positive regulation of dendritic spine development (GO:0060999)	2.45676658
69	negative regulation of synaptic transmission, glutamatergic (GO:0051967)	2.45143235
70	presynaptic membrane assembly (GO:0097105)	2.42801824
71	metanephric mesenchyme development (GO:0072075)	2.41605922
72	axon extension involved in axon guidance (GO:0048846)	2.40428641
73	neuron projection extension involved in neuron projection guidance (GO:1902284)	2.40428641
74	regulation of voltage-gated calcium channel activity (GO:1901385)	2.40147438
75	negative regulation of catenin import into nucleus (GO:0035414)	2.38783732
76	gamma-aminobutyric acid transport (GO:0015812)	2.37829236
77	membrane assembly (GO:0071709)	2.37270537
78	ionotropic glutamate receptor signaling pathway (GO:0035235)	2.36458907
79	positive regulation of axon extension (GO:0045773)	2.36300949
80	positive regulation of neurotransmitter transport (GO:0051590)	2.36282040
81	transmission of nerve impulse (GO:0019226)	2.34200008
82	regulation of neurotransmitter transport (GO:0051588)	2.33479188
83	neuromuscular process controlling balance (GO:0050885)	2.30386155
84	detection of calcium ion (GO:0005513)	2.30355053
85	neurotransmitter transport (GO:0006836)	2.30177140
86	regulation of vesicle fusion (GO:0031338)	2.30026406
87	regulation of synapse assembly (GO:0051963)	2.29582918
88	potassium ion homeostasis (GO:0055075)	2.28982537
89	neuron-neuron synaptic transmission (GO:0007270)	2.28219737
90	regulation of synaptic plasticity (GO:0048167)	2.27820155
91	acidic amino acid transport (GO:0015800)	2.25167736
92	G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)	2.24958612
93	regulation of neurotransmitter levels (GO:0001505)	2.24418676
94	positive regulation of membrane potential (GO:0045838)	2.23933256
95	regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)	2.23883523
96	regulation of excitatory postsynaptic membrane potential (GO:0060079)	2.23568431
97	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO	2.22995148
98	actin filament depolymerization (GO:0030042)	2.21321526
99	synapse assembly (GO:0007416)	2.20732237
100	response to dietary excess (GO:0002021)	2.20509061

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	4.46804624
2	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	3.73171479
3	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	3.56836845
4	TRIM28_21343339_ChIP-Seq_HEK293_Human	2.96141167
5	EED_16625203_ChIP-ChIP_MESCs_Mouse	2.80101939
6	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	2.79265423
7	EZH2_18974828_ChIP-Seq_MESCs_Mouse	2.68901445
8	RNF2_18974828_ChIP-Seq_MESCs_Mouse	2.68901445
9	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	2.66590558
10	EZH2_27304074_Chip-Seq_ESCs_Mouse	2.65691803
11	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	2.63839736
12	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	2.63747707
13	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	2.61976466
14	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	2.57879181
15	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	2.56477514
16	JARID2_20075857_ChIP-Seq_MESCs_Mouse	2.52597713
17	JARID2_20064375_ChIP-Seq_MESCs_Mouse	2.51672981
18	EZH2_27294783_Chip-Seq_ESCs_Mouse	2.44214131
19	RARG_19884340_ChIP-ChIP_MEFs_Mouse	2.42074295
20	SUZ12_27294783_Chip-Seq_ESCs_Mouse	2.40804881
21	MTF2_20144788_ChIP-Seq_MESCs_Mouse	2.34488435
22	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	2.34187195
23	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	2.33518293
24	RNF2_27304074_Chip-Seq_ESCs_Mouse	2.25318448
25	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	2.11201746
26	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	2.06141237
27	ZFP281_18757296_ChIP-ChIP_E14_Mouse	1.97702299
28	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.93497294
29	REST_21632747_ChIP-Seq_MESCs_Mouse	1.89932044
30	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.87703616
31	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.87521318
32	RARB_27405468_Chip-Seq_BRAIN_Mouse	1.79967715
33	DNAJC2_21179169_ChIP-ChIP_NT2_Human	1.77391125
34	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.74455391
35	ZFP281_18358816_ChIP-ChIP_MESCs_Mouse	1.72429197
36	OLIG2_26023283_ChIP-Seq_AINV15_Mouse	1.68713617
37	WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse	1.65354131
38	DROSHA_22980978_ChIP-Seq_HELA_Human	1.62777120
39	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.61447728
40	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.59517043
41	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.58832239
42	CTCF_27219007_Chip-Seq_Bcells_Human	1.58045490
43	RING1B_27294783_Chip-Seq_ESCs_Mouse	1.56085111
44	LXR_22292898_ChIP-Seq_THP-1_Human	1.55093547
45	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.54039899
46	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.52479942
47	EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse	1.49612513
48	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.48441190
49	EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human	1.47291314
50	KDM2B_26808549_Chip-Seq_K562_Human	1.47180492
51	TET1_21490601_ChIP-Seq_MESCs_Mouse	1.39834835
52	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	1.36293688
53	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.26659898
54	UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	1.26235014
55	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.20640955
56	RCOR3_21632747_ChIP-Seq_MESCs_Mouse	1.20415754
57	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.16847527
58	SMAD3_22036565_ChIP-Seq_ESCs_Mouse	1.14574037
59	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.11143758
60	RING1B_27294783_Chip-Seq_NPCs_Mouse	1.10767635
61	ZFP281_27345836_Chip-Seq_ESCs_Mouse	1.08484571
62	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	1.06368473
63	SETDB1_19884255_ChIP-Seq_MESCs_Mouse	1.03827280
64	TP53_23651856_ChIP-Seq_MEFs_Mouse	1.03823307
65	SMC3_22415368_ChIP-Seq_MEFs_Mouse	1.03737444
66	RUNX2_24764292_ChIP-Seq_MC3T3_Mouse	1.01754770
67	RAD21_21589869_ChIP-Seq_MESCs_Mouse	1.00265512
68	ESR2_21235772_ChIP-Seq_MCF-7_Human	0.98745513
69	GBX2_23144817_ChIP-Seq_PC3_Human	0.95343611
70	WT1_25993318_ChIP-Seq_PODOCYTE_Human	0.94944869
71	TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.94545758
72	RNF2_27304074_Chip-Seq_NSC_Mouse	0.94134895
73	ELK3_25401928_ChIP-Seq_HUVEC_Human	0.93716670
74	SA1_22415368_ChIP-Seq_MEFs_Mouse	0.90145239
75	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	0.89875155
76	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	0.89078778
77	MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human	0.89051752
78	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	0.89031494
79	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	0.88607072
80	TP53_22127205_ChIP-Seq_IMR90_Human	0.87576725
81	SMC1_22415368_ChIP-Seq_MEFs_Mouse	0.87384095
82	EP300_21415370_ChIP-Seq_HL-1_Mouse	0.86939406
83	CTCF_18555785_ChIP-Seq_MESCs_Mouse	0.86781501
84	NR0B1_18358816_ChIP-ChIP_MESCs_Mouse	0.86401934
85	CLOCK_20551151_ChIP-Seq_293T_Human	0.86332470
86	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	0.86233820
87	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	0.85919356
88	SA1_27219007_Chip-Seq_ERYTHROID_Human	0.85588371
89	KDM2B_26808549_Chip-Seq_SUP-B15_Human	0.84216415
90	P68_20966046_ChIP-Seq_HELA_Human	0.84010750
91	SMC4_20622854_ChIP-Seq_HELA_Human	0.83076984
92	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	0.82369802
93	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.81800806
94	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	0.80696176
95	NFIB_24661679_ChIP-Seq_LUNG_Mouse	0.75269601
96	CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse	0.75151008
97	NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse	0.74798015
98	ESR1_22446102_ChIP-Seq_UTERUS_Mouse	0.73929841
99	WT1_19549856_ChIP-ChIP_CCG9911_Human	0.73553194
100	SOX3_22085726_ChIP-Seq_NPCs_Mouse	0.73386809

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0004859_abnormal_synaptic_plasticity	4.72573438
2	MP0003880_abnormal_central_pattern	3.30802423
3	MP0008438_abnormal_cutaneous_collagen	3.17499132
4	MP0004270_analgesia	2.83546998
5	MP0005423_abnormal_somatic_nervous	2.72541767
6	MP0000751_myopathy	2.60181256
7	MP0003635_abnormal_synaptic_transmissio	2.57666444
8	MP0002063_abnormal_learning/memory/cond	2.08867210
9	MP0002064_seizures	2.06551721
10	MP0006276_abnormal_autonomic_nervous	1.97608443
11	MP0000778_abnormal_nervous_system	1.91837683
12	MP0009745_abnormal_behavioral_response	1.90746088
13	MP0005503_abnormal_tendon_morphology	1.90012382
14	MP0002734_abnormal_mechanical_nocicepti	1.89167585
15	MP0002572_abnormal_emotion/affect_behav	1.86021134
16	MP0002272_abnormal_nervous_system	1.84944772
17	MP0003329_amyloid_beta_deposits	1.83586098
18	MP0003279_aneurysm	1.79761913
19	MP0001958_emphysema	1.76145932
20	MP0005623_abnormal_meninges_morphology	1.74843987
21	MP0003122_maternal_imprinting	1.72869718
22	MP0005257_abnormal_intraocular_pressure	1.69356525
23	MP0009780_abnormal_chondrocyte_physiolo	1.63755984
24	MP0010030_abnormal_orbit_morphology	1.61435827
25	MP0000749_muscle_degeneration	1.58695234
26	MP0009046_muscle_twitch	1.56647361
27	MP0004272_abnormal_basement_membrane	1.55346631
28	MP0001968_abnormal_touch/_nociception	1.52543514
29	MP0001486_abnormal_startle_reflex	1.50464720
30	MP0001970_abnormal_pain_threshold	1.47611984
31	MP0001299_abnormal_eye_distance/	1.45442310
32	MP0001905_abnormal_dopamine_level	1.45171088
33	MP0002822_catalepsy	1.45089527
34	MP0001529_abnormal_vocalization	1.44846023
35	MP0002733_abnormal_thermal_nociception	1.42734313
36	MP0004858_abnormal_nervous_system	1.41864550
37	MP0003705_abnormal_hypodermis_morpholog	1.40221660
38	MP0000750_abnormal_muscle_regeneration	1.38408588
39	MP0002653_abnormal_ependyma_morphology	1.38292589
40	MP0004811_abnormal_neuron_physiology	1.37685186
41	MP0008569_lethality_at_weaning	1.36716776
42	MP0003123_paternal_imprinting	1.34704618
43	MP0001542_abnormal_bone_strength	1.32783920
44	MP0000955_abnormal_spinal_cord	1.31304991
45	MP0003879_abnormal_hair_cell	1.30551856
46	MP0002557_abnormal_social/conspecific_i	1.27681293
47	MP0002736_abnormal_nociception_after	1.24729846
48	MP0002882_abnormal_neuron_morphology	1.23837721
49	MP0002184_abnormal_innervation	1.23737765
50	MP0002735_abnormal_chemical_nociception	1.23044646
51	MP0009384_cardiac_valve_regurgitation	1.22717446
52	MP0005275_abnormal_skin_tensile	1.21214157
53	MP0004145_abnormal_muscle_electrophysio	1.18065558
54	MP0002295_abnormal_pulmonary_circulatio	1.17651718
55	MP0000534_abnormal_ureter_morphology	1.15493076
56	MP0000049_abnormal_middle_ear	1.14678807
57	MP0004885_abnormal_endolymph	1.13200076
58	MP0002067_abnormal_sensory_capabilities	1.10952748
59	MP0002066_abnormal_motor_capabilities/c	1.10036193
60	MP0001502_abnormal_circadian_rhythm	1.09223850
61	MP0003634_abnormal_glial_cell	1.08793863
62	MP0010368_abnormal_lymphatic_system	1.05416828
63	MP0003942_abnormal_urinary_system	1.05063592
64	MP0005508_abnormal_skeleton_morphology	1.03138540
65	MP0001440_abnormal_grooming_behavior	1.00743595
66	MP0002837_dystrophic_cardiac_calcinosis	1.00584805
67	MP0001984_abnormal_olfaction	0.98997428
68	MP0003137_abnormal_impulse_conducting	0.98493169
69	MP0002249_abnormal_larynx_morphology	0.95360374
70	MP0002152_abnormal_brain_morphology	0.93349702
71	MP0000759_abnormal_skeletal_muscle	0.92779711
72	MP0005394_taste/olfaction_phenotype	0.92136136
73	MP0005499_abnormal_olfactory_system	0.92136136
74	MP0000013_abnormal_adipose_tissue	0.91019383
75	MP0010386_abnormal_urinary_bladder	0.88552262
76	MP0004142_abnormal_muscle_tone	0.88336158
77	MP0003385_abnormal_body_wall	0.88113938
78	MP0008789_abnormal_olfactory_epithelium	0.86182134
79	MP0004924_abnormal_behavior	0.85157962
80	MP0005386_behavior/neurological_phenoty	0.85157962
81	MP0003633_abnormal_nervous_system	0.84611479
82	MP0005620_abnormal_muscle_contractility	0.83878511
83	MP0000747_muscle_weakness	0.83699737
84	MP0004510_myositis	0.83641688
85	MP0002752_abnormal_somatic_nervous	0.83538417
86	MP0002638_abnormal_pupillary_reflex	0.83033061
87	MP0000026_abnormal_inner_ear	0.82420518
88	MP0000920_abnormal_myelination	0.82351901
89	MP0003121_genomic_imprinting	0.80702914
90	MP0005595_abnormal_vascular_smooth	0.77565685
91	MP0001963_abnormal_hearing_physiology	0.75430573
92	MP0003283_abnormal_digestive_organ	0.74435436
93	MP0001501_abnormal_sleep_pattern	0.74421401
94	MP0002972_abnormal_cardiac_muscle	0.72024347
95	MP0005369_muscle_phenotype	0.71993544
96	MP0002106_abnormal_muscle_physiology	0.71953942
97	MP0004087_abnormal_muscle_fiber	0.71888915
98	MP0002108_abnormal_muscle_morphology	0.70631946
99	MP0009250_abnormal_appendicular_skeleto	0.70476425
100	MP0003787_abnormal_imprinting	0.70147566

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Myokymia (HP:0002411)	4.97228412
2	Premature rupture of membranes (HP:0001788)	4.38834264
3	Protrusio acetabuli (HP:0003179)	3.98164878
4	Type 1 muscle fiber predominance (HP:0003803)	3.28905821
5	Supranuclear gaze palsy (HP:0000605)	3.00904512
6	Hand muscle atrophy (HP:0009130)	2.94932993
7	Distal upper limb amyotrophy (HP:0007149)	2.93851435
8	Upper limb amyotrophy (HP:0009129)	2.93851435
9	Focal motor seizures (HP:0011153)	2.91569591
10	Abnormal eating behavior (HP:0100738)	2.79204267
11	Bladder diverticulum (HP:0000015)	2.77990548
12	Polyphagia (HP:0002591)	2.77713916
13	Focal seizures (HP:0007359)	2.77595567
14	Limb dystonia (HP:0002451)	2.76735988
15	Torticollis (HP:0000473)	2.71271986
16	Hypoventilation (HP:0002791)	2.69712769
17	Spinal rigidity (HP:0003306)	2.65708069
18	Abnormality of dentin (HP:0010299)	2.61036299
19	Shallow orbits (HP:0000586)	2.48631088
20	Ankle contracture (HP:0006466)	2.40160888
21	Focal dystonia (HP:0004373)	2.37244339
22	Action tremor (HP:0002345)	2.36936007
23	Neurofibrillary tangles (HP:0002185)	2.34407465
24	Myotonia (HP:0002486)	2.34397413
25	Increased variability in muscle fiber diameter (HP:0003557)	2.33855709
26	Ankle clonus (HP:0011448)	2.31052886
27	Craniofacial dystonia (HP:0012179)	2.25314780
28	Atrophic scars (HP:0001075)	2.23616550
29	Round ear (HP:0100830)	2.22931766
30	Mildly elevated creatine phosphokinase (HP:0008180)	2.20984001
31	Vascular tortuosity (HP:0004948)	2.16626545
32	Atonic seizures (HP:0010819)	2.15624773
33	Bowel diverticulosis (HP:0005222)	2.13406636
34	Insomnia (HP:0100785)	2.12803720
35	Follicular hyperkeratosis (HP:0007502)	2.11110684
36	Slender build (HP:0001533)	2.09007290
37	Lower limb amyotrophy (HP:0007210)	2.08886269
38	Soft skin (HP:0000977)	2.08815240
39	Infantile muscular hypotonia (HP:0008947)	2.07975160
40	Abnormality of the lower motor neuron (HP:0002366)	2.06968838
41	Distal lower limb muscle weakness (HP:0009053)	2.06258164
42	Amblyopia (HP:0000646)	2.06200543
43	Mitral regurgitation (HP:0001653)	2.04433742
44	Obstructive sleep apnea (HP:0002870)	2.04255182
45	Aortic dissection (HP:0002647)	2.03608416
46	Akinesia (HP:0002304)	2.02350801
47	Wormian bones (HP:0002645)	2.01487210
48	Epileptic encephalopathy (HP:0200134)	2.00565142
49	Achilles tendon contracture (HP:0001771)	1.99180563
50	Sleep apnea (HP:0010535)	1.97481036
51	Broad metatarsal (HP:0001783)	1.97026863
52	Vertebral compression fractures (HP:0002953)	1.95997577
53	Diplopia (HP:0000651)	1.95899087
54	Abnormality of binocular vision (HP:0011514)	1.95899087
55	Abnormality of the calf musculature (HP:0001430)	1.91577221
56	Difficulty climbing stairs (HP:0003551)	1.90629288
57	Limb-girdle muscle weakness (HP:0003325)	1.90489270
58	Abnormality of skeletal muscle fiber size (HP:0012084)	1.89635825
59	Spastic gait (HP:0002064)	1.87129698
60	Turricephaly (HP:0000262)	1.85754065
61	Cerebral inclusion bodies (HP:0100314)	1.84909460
62	Fetal akinesia sequence (HP:0001989)	1.84724322
63	Neonatal short-limb short stature (HP:0008921)	1.84467096
64	Generalized tonic-clonic seizures (HP:0002069)	1.81500253
65	Wrist flexion contracture (HP:0001239)	1.81118580
66	Aortic aneurysm (HP:0004942)	1.81003676
67	Fragile skin (HP:0001030)	1.81000739
68	Cerebral hypomyelination (HP:0006808)	1.76054028
69	Sudden death (HP:0001699)	1.74388826
70	Abnormality of the pulmonary veins (HP:0011718)	1.74359763
71	Febrile seizures (HP:0002373)	1.74097582
72	Genu recurvatum (HP:0002816)	1.73567442
73	Arterial tortuosity (HP:0005116)	1.73425054
74	Muscle fiber splitting (HP:0003555)	1.71917499
75	Hyperextensible skin (HP:0000974)	1.70794708
76	Poor suck (HP:0002033)	1.70222690
77	Calcaneovalgus deformity (HP:0001848)	1.69117577
78	Anomalous pulmonary venous return (HP:0010772)	1.69044797
79	Distal lower limb amyotrophy (HP:0008944)	1.68047620
80	Delayed gross motor development (HP:0002194)	1.67819429
81	Long toe (HP:0010511)	1.67797446
82	Deformed tarsal bones (HP:0008119)	1.67011903
83	Abnormality of the Achilles tendon (HP:0005109)	1.66115950
84	Mutism (HP:0002300)	1.65231312
85	Cerebral aneurysm (HP:0004944)	1.65068604
86	Retinal dysplasia (HP:0007973)	1.64655036
87	Lower limb muscle weakness (HP:0007340)	1.63795660
88	Hyporeflexia of lower limbs (HP:0002600)	1.63084580
89	Annular pancreas (HP:0001734)	1.62666233
90	Hypoplastic left heart (HP:0004383)	1.61018480
91	Bundle branch block (HP:0011710)	1.60737818
92	Visual hallucinations (HP:0002367)	1.60596472
93	Distal arthrogryposis (HP:0005684)	1.60007214
94	Renal duplication (HP:0000075)	1.59968365
95	Wide anterior fontanel (HP:0000260)	1.58915404
96	Failure to thrive in infancy (HP:0001531)	1.58631459
97	Limb-girdle muscle atrophy (HP:0003797)	1.58461175
98	Hyperacusis (HP:0010780)	1.57573857
99	Bradycardia (HP:0001662)	1.57148968
100	Supraventricular arrhythmia (HP:0005115)	1.56812495

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MARK1	4.29662067
2	LIMK1	3.37597726
3	TESK1	3.20282354
4	PAK6	3.03183422
5	EPHA4	2.70420230
6	ARAF	2.47994655
7	EPHB2	2.26099924
8	NTRK1	2.16802450
9	NTRK3	1.96192873
10	PRKD3	1.95159715
11	NTRK2	1.94531189
12	PHKG2	1.91725895
13	PHKG1	1.91725895
14	CASK	1.83650678
15	MINK1	1.73908663
16	UHMK1	1.70494936
17	DAPK2	1.68993793
18	MYLK	1.68019753
19	MAP2K7	1.64428536
20	GRK5	1.54451089
21	PIM2	1.52971399
22	BCKDK	1.47762485
23	TESK2	1.39585434
24	DYRK2	1.35650480
25	PINK1	1.33754481
26	LMTK2	1.32907848
27	LATS2	1.24466615
28	CDK14	1.19498283
29	MOS	1.17573156
30	CAMK2G	1.17567034
31	CDK15	1.16877460
32	CSNK1G2	1.16495521
33	CDK5	1.16469800
34	PLK2	1.16158500
35	MAP3K11	1.15339478
36	DDR2	1.14968686
37	CAMK2B	1.14671839
38	CDK18	1.14129089
39	PAK3	1.13077713
40	CDK11A	1.12338214
41	PTK2	1.12110406
42	DAPK3	1.08343939
43	CSNK1G3	1.07841881
44	TTN	1.03303505
45	PRKCG	0.99153712
46	CAMKK1	0.98830650
47	MAPK13	0.97393676
48	ABL2	0.96048767
49	PDGFRA	0.92531386
50	CAMK1	0.92039462
51	DYRK1B	0.92038696
52	MARK2	0.91396258
53	ROCK2	0.90704543
54	MAP3K9	0.89497590
55	SIK2	0.86809533
56	CDK19	0.86436536
57	PRKD2	0.86128472
58	STK38	0.85508867
59	DMPK	0.84629645
60	CAMK2D	0.84598295
61	TYRO3	0.84000470
62	CSNK1A1L	0.82547240
63	PKN1	0.82077818
64	CAMK2A	0.81379911
65	RIPK1	0.80808324
66	EPHB1	0.80299944
67	DAPK1	0.79335177
68	BRAF	0.77627021
69	PAK2	0.75905468
70	ROCK1	0.75393797
71	MAP3K4	0.74999922
72	MAP2K4	0.74751045
73	RPS6KA2	0.69509383
74	BCR	0.64104059
75	CSNK1G1	0.63517578
76	DYRK1A	0.60134082
77	SIK1	0.59127841
78	EPHA3	0.58490096
79	MAPK12	0.58248806
80	SGK223	0.58135606
81	SGK494	0.58135606
82	BRSK1	0.58021180
83	PRKD1	0.57996576
84	MAP4K2	0.57432209
85	ILK	0.56633662
86	TRIB3	0.54068061
87	PAK1	0.53459220
88	PRKCH	0.52614119
89	TAOK2	0.51767154
90	ADRBK1	0.51390844
91	ICK	0.50091064
92	MAP3K12	0.47072690
93	PRKCE	0.45837789
94	MUSK	0.45135277
95	MAPKAPK5	0.45041772
96	KSR1	0.44539660
97	MAP3K6	0.43623546
98	GRK7	0.39683148
99	MAPKAPK3	0.39529999
100	AKT2	0.38660889

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synaptic vesicle cycle_Homo sapiens_hsa04721	3.28796541
2	Nicotine addiction_Homo sapiens_hsa05033	2.61508101
3	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	2.37587793
4	Cardiac muscle contraction_Homo sapiens_hsa04260	2.25607177
5	GABAergic synapse_Homo sapiens_hsa04727	2.14915535
6	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	2.09322919
7	Cocaine addiction_Homo sapiens_hsa05030	2.00685788
8	Dilated cardiomyopathy_Homo sapiens_hsa05414	1.90478089
9	Circadian entrainment_Homo sapiens_hsa04713	1.86920886
10	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.86167586
11	Insulin secretion_Homo sapiens_hsa04911	1.85397954
12	Morphine addiction_Homo sapiens_hsa05032	1.82874318
13	Amphetamine addiction_Homo sapiens_hsa05031	1.79505410
14	Dopaminergic synapse_Homo sapiens_hsa04728	1.74772656
15	Glutamatergic synapse_Homo sapiens_hsa04724	1.71145696
16	Vibrio cholerae infection_Homo sapiens_hsa05110	1.71139004
17	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	1.66522489
18	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	1.61879813
19	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	1.54009042
20	Axon guidance_Homo sapiens_hsa04360	1.51991914
21	Oxidative phosphorylation_Homo sapiens_hsa00190	1.50674274
22	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	1.49702501
23	Parkinsons disease_Homo sapiens_hsa05012	1.48770968
24	Gastric acid secretion_Homo sapiens_hsa04971	1.34279118
25	Cholinergic synapse_Homo sapiens_hsa04725	1.32491373
26	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.31753946
27	Gap junction_Homo sapiens_hsa04540	1.28555389
28	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	1.28441476
29	Alzheimers disease_Homo sapiens_hsa05010	1.27415407
30	Long-term potentiation_Homo sapiens_hsa04720	1.27093882
31	Salivary secretion_Homo sapiens_hsa04970	1.26580223
32	Sulfur relay system_Homo sapiens_hsa04122	1.25058411
33	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.22763487
34	Oxytocin signaling pathway_Homo sapiens_hsa04921	1.19466019
35	Collecting duct acid secretion_Homo sapiens_hsa04966	1.17979234
36	ECM-receptor interaction_Homo sapiens_hsa04512	1.13631889
37	Melanogenesis_Homo sapiens_hsa04916	1.09787990
38	cAMP signaling pathway_Homo sapiens_hsa04024	1.04224628
39	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.99955954
40	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.98877839
41	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.97062144
42	Prion diseases_Homo sapiens_hsa05020	0.96157057
43	Arginine and proline metabolism_Homo sapiens_hsa00330	0.95860246
44	Calcium signaling pathway_Homo sapiens_hsa04020	0.95658344
45	Fatty acid elongation_Homo sapiens_hsa00062	0.94215494
46	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.91772417
47	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.88968891
48	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.85693547
49	Focal adhesion_Homo sapiens_hsa04510	0.84545760
50	Huntingtons disease_Homo sapiens_hsa05016	0.84041938
51	Hippo signaling pathway_Homo sapiens_hsa04390	0.83969724
52	Renin secretion_Homo sapiens_hsa04924	0.83685667
53	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.82809408
54	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.81961688
55	Long-term depression_Homo sapiens_hsa04730	0.80324629
56	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.79095822
57	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.78511478
58	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.75464942
59	Serotonergic synapse_Homo sapiens_hsa04726	0.74230758
60	GnRH signaling pathway_Homo sapiens_hsa04912	0.70964601
61	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.70016079
62	Basal cell carcinoma_Homo sapiens_hsa05217	0.68915714
63	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.67716088
64	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.66373531
65	Estrogen signaling pathway_Homo sapiens_hsa04915	0.64993258
66	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.64464726
67	Protein digestion and absorption_Homo sapiens_hsa04974	0.64440017
68	Taste transduction_Homo sapiens_hsa04742	0.64207190
69	Endocytosis_Homo sapiens_hsa04144	0.62870083
70	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.62764345
71	Rap1 signaling pathway_Homo sapiens_hsa04015	0.60374119
72	Phototransduction_Homo sapiens_hsa04744	0.60362968
73	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.60199869
74	Steroid biosynthesis_Homo sapiens_hsa00100	0.59848542
75	Tight junction_Homo sapiens_hsa04530	0.59453989
76	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.59004295
77	Glioma_Homo sapiens_hsa05214	0.59001770
78	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.57165312
79	Carbon metabolism_Homo sapiens_hsa01200	0.56916509
80	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.56598185
81	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.56234674
82	Ras signaling pathway_Homo sapiens_hsa04014	0.54523470
83	AMPK signaling pathway_Homo sapiens_hsa04152	0.54073542
84	Wnt signaling pathway_Homo sapiens_hsa04310	0.53958077
85	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.53340025
86	Notch signaling pathway_Homo sapiens_hsa04330	0.53222317
87	Glucagon signaling pathway_Homo sapiens_hsa04922	0.52951117
88	beta-Alanine metabolism_Homo sapiens_hsa00410	0.52561741
89	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.50043821
90	Folate biosynthesis_Homo sapiens_hsa00790	0.49879264
91	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.49261891
92	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.49145863
93	Pyruvate metabolism_Homo sapiens_hsa00620	0.47870897
94	Regulation of actin cytoskeleton_Homo sapiens_hsa04810	0.47845025
95	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.46539088
96	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.46252703
97	MAPK signaling pathway_Homo sapiens_hsa04010	0.44617033
98	Bile secretion_Homo sapiens_hsa04976	0.43451342
99	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.42029039
100	Olfactory transduction_Homo sapiens_hsa04740	0.41987608

FAM127A

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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