ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	chaperone-mediated protein transport (GO:0072321)	3.89730875
2	protein maturation by protein folding (GO:0022417)	3.78087317
3	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.78014618
4	proteasome assembly (GO:0043248)	3.71334515
5	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.53011319
6	ATP synthesis coupled proton transport (GO:0015986)	3.44979376
7	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.44979376
8	protein complex biogenesis (GO:0070271)	3.44657947
9	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.40885016
10	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	3.35787190
11	positive regulation of mitochondrial fission (GO:0090141)	3.34507425
12	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.30405622
13	NADH dehydrogenase complex assembly (GO:0010257)	3.30405622
14	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.30405622
15	protein neddylation (GO:0045116)	3.25096976
16	cullin deneddylation (GO:0010388)	3.22600922
17	mitochondrial respiratory chain complex assembly (GO:0033108)	3.18934755
18	respiratory electron transport chain (GO:0022904)	3.13309479
19	electron transport chain (GO:0022900)	3.10649110
20	protein deneddylation (GO:0000338)	3.03576588
21	establishment of integrated proviral latency (GO:0075713)	3.01989976
22	regulation of mitochondrial translation (GO:0070129)	2.98532311
23	GTP biosynthetic process (GO:0006183)	2.98263714
24	protein targeting to mitochondrion (GO:0006626)	2.97454721
25	nuclear envelope reassembly (GO:0031468)	2.97439876
26	mitotic nuclear envelope reassembly (GO:0007084)	2.97439876
27	establishment of protein localization to mitochondrion (GO:0072655)	2.83751792
28	establishment of viral latency (GO:0019043)	2.83064527
29	guanosine-containing compound biosynthetic process (GO:1901070)	2.76135714
30	protein localization to mitochondrion (GO:0070585)	2.74622585
31	protein retention in ER lumen (GO:0006621)	2.72933120
32	sequestering of actin monomers (GO:0042989)	2.70958218
33	metallo-sulfur cluster assembly (GO:0031163)	2.69073455
34	iron-sulfur cluster assembly (GO:0016226)	2.69073455
35	UTP biosynthetic process (GO:0006228)	2.68675899
36	DNA damage response, detection of DNA damage (GO:0042769)	2.65531524
37	termination of RNA polymerase III transcription (GO:0006386)	2.61488811
38	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.61488811
39	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	2.60065708
40	CTP metabolic process (GO:0046036)	2.57152960
41	CTP biosynthetic process (GO:0006241)	2.57152960
42	maintenance of protein localization in endoplasmic reticulum (GO:0035437)	2.56805883
43	L-serine metabolic process (GO:0006563)	2.55786609
44	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.55099219
45	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.55099219
46	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.50221312
47	response to gravity (GO:0009629)	2.49154440
48	positive regulation of actin filament depolymerization (GO:0030836)	2.48766034
49	peptidyl-histidine modification (GO:0018202)	2.46606785
50	positive regulation of TOR signaling (GO:0032008)	2.46084868
51	oxidative phosphorylation (GO:0006119)	2.45637388
52	UTP metabolic process (GO:0046051)	2.45585080
53	establishment of mitochondrion localization (GO:0051654)	2.45263045
54	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	2.44759471
55	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.42031031
56	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.41096024
57	peptidyl-arginine omega-N-methylation (GO:0035247)	2.40205382
58	spliceosomal snRNP assembly (GO:0000387)	2.38853423
59	pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)	2.38067914
60	base-excision repair, AP site formation (GO:0006285)	2.36989759
61	mannosylation (GO:0097502)	2.36221154
62	regulation of cellular amino acid metabolic process (GO:0006521)	2.35957227
63	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.34935543
64	respiratory chain complex IV assembly (GO:0008535)	2.33145720
65	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	2.31571157
66	substrate-independent telencephalic tangential migration (GO:0021826)	2.31571157
67	protein insertion into membrane (GO:0051205)	2.31128525
68	pyrimidine nucleobase catabolic process (GO:0006208)	2.30020017
69	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.28707312
70	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.27525388
71	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.24920075
72	histone arginine methylation (GO:0034969)	2.24492200
73	postsynaptic membrane organization (GO:0001941)	2.24343561
74	ATP biosynthetic process (GO:0006754)	2.24273342
75	pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)	2.22664573
76	protein-cofactor linkage (GO:0018065)	2.19804662
77	lipopolysaccharide biosynthetic process (GO:0009103)	2.19198531
78	negative regulation of ligase activity (GO:0051352)	2.18434572
79	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.18434572
80	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.17910787
81	cerebellar Purkinje cell layer development (GO:0021680)	2.17632847
82	ATP hydrolysis coupled proton transport (GO:0015991)	2.17352772
83	energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)	2.17352772
84	C-terminal protein lipidation (GO:0006501)	2.15258990
85	nucleoside triphosphate biosynthetic process (GO:0009142)	2.13652301
86	regulation of mitochondrial fission (GO:0090140)	2.13140269
87	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.12996549
88	hydrogen ion transmembrane transport (GO:1902600)	2.12724252
89	cytochrome complex assembly (GO:0017004)	2.12318928
90	branched-chain amino acid catabolic process (GO:0009083)	2.12062632
91	negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)	2.11528880
92	cell migration in hindbrain (GO:0021535)	2.11098857
93	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	2.09890049
94	regulation of cilium movement (GO:0003352)	2.09085423
95	positive regulation of mitochondrial calcium ion concentration (GO:0051561)	2.06117708
96	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	2.04860997
97	peptidyl-arginine methylation (GO:0018216)	2.04189278
98	peptidyl-arginine N-methylation (GO:0035246)	2.04189278
99	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.03962689
100	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.03962689

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	4.28057841
2	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.56593736
3	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	3.30771034
4	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.29173146
5	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.24032843
6	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.91538183
7	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.91414577
8	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.84718908
9	THAP11_20581084_ChIP-Seq_MESCs_Mouse	2.84175499
10	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	2.69328282
11	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.60338129
12	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.57983297
13	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.54128155
14	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.44644076
15	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.34903720
16	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	2.31874669
17	XRN2_22483619_ChIP-Seq_HELA_Human	2.30875452
18	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.29852650
19	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	2.20003616
20	GABP_19822575_ChIP-Seq_HepG2_Human	2.16258510
21	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	2.03575407
22	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.99586444
23	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.97890145
24	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.97239129
25	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.87752771
26	DCP1A_22483619_ChIP-Seq_HELA_Human	1.84547039
27	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.80565246
28	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.78916157
29	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.77260192
30	TTF2_22483619_ChIP-Seq_HELA_Human	1.71674521
31	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.64151291
32	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.62500563
33	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.61278029
34	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.60627162
35	CTCF_18555785_ChIP-Seq_MESCs_Mouse	1.54833529
36	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	1.52961446
37	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.46618824
38	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.45473328
39	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	1.44998738
40	ZFP281_18358816_ChIP-ChIP_MESCs_Mouse	1.43943691
41	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.41748919
42	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.39545420
43	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.35668917
44	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	1.35169426
45	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.34318369
46	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.32538347
47	FOXP1_21924763_ChIP-Seq_HESCs_Human	1.29606319
48	KDM5A_27292631_Chip-Seq_BREAST_Human	1.29346270
49	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.28615227
50	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.27141533
51	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.25121702
52	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.24233265
53	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.23390264
54	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	1.22131287
55	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.21355450
56	HIF1A_21447827_ChIP-Seq_MCF-7_Human	1.20855795
57	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.19852322
58	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.14855350
59	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.13508242
60	VDR_23849224_ChIP-Seq_CD4+_Human	1.13263857
61	FOXP3_21729870_ChIP-Seq_TREG_Human	1.12261992
62	ZNF263_19887448_ChIP-Seq_K562_Human	1.11824085
63	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.10173164
64	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	1.09914917
65	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.09632918
66	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.09328164
67	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.09067421
68	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.08990163
69	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.08657629
70	CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse	1.08554043
71	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.07589262
72	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.06524592
73	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.06413892
74	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.04283425
75	TRIM28_19339689_ChIP-ChIP_MESCs_Mouse	1.03811908
76	SETDB1_19884255_ChIP-Seq_MESCs_Mouse	1.02951200
77	TBX5_21415370_ChIP-Seq_HL-1_Mouse	0.98693679
78	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	0.97341296
79	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.97049225
80	ATF3_23680149_ChIP-Seq_GBM1-GSC_Human	0.95502350
81	OLIG2_26023283_ChIP-Seq_AINV15_Mouse	0.94691586
82	ERG_21242973_ChIP-ChIP_JURKAT_Human	0.94098526
83	MYC_18940864_ChIP-ChIP_HL60_Human	0.94029377
84	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	0.93827096
85	* PRDM5_23873026_ChIP-Seq_MEFs_Mouse	0.91509503
86	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.91276606
87	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	0.90618879
88	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.90517032
89	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	0.89797108
90	OCT4_18692474_ChIP-Seq_MEFs_Mouse	0.89182950
91	SOX2_18555785_ChIP-Seq_MESCs_Mouse	0.87702855
92	KLF4_18555785_ChIP-Seq_MESCs_Mouse	0.87110925
93	ELK1_19687146_ChIP-ChIP_HELA_Human	0.86110542
94	ZFP281_18757296_ChIP-ChIP_E14_Mouse	0.84416923
95	P68_20966046_ChIP-Seq_HELA_Human	0.83594924
96	NR0B1_18358816_ChIP-ChIP_MESCs_Mouse	0.83353533
97	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.81960799
98	EOMES_21245162_ChIP-Seq_HESCs_Human	0.81880275
99	SOX2_18692474_ChIP-Seq_MEFs_Mouse	0.81487500
100	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	0.80543281

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0010030_abnormal_orbit_morphology	2.79078980
2	MP0003880_abnormal_central_pattern	2.47228500
3	MP0003123_paternal_imprinting	2.42218252
4	MP0001529_abnormal_vocalization	2.27323409
5	MP0002234_abnormal_pharynx_morphology	2.02471012
6	MP0008789_abnormal_olfactory_epithelium	1.99942002
7	MP0004859_abnormal_synaptic_plasticity	1.92621681
8	MP0000049_abnormal_middle_ear	1.91989277
9	MP0006292_abnormal_olfactory_placode	1.82358594
10	MP0002653_abnormal_ependyma_morphology	1.78068604
11	MP0002249_abnormal_larynx_morphology	1.75079511
12	MP0003186_abnormal_redox_activity	1.70734784
13	MP0005499_abnormal_olfactory_system	1.68770372
14	MP0005394_taste/olfaction_phenotype	1.68770372
15	MP0006276_abnormal_autonomic_nervous	1.63637294
16	MP0005423_abnormal_somatic_nervous	1.61734494
17	MP0005623_abnormal_meninges_morphology	1.61154044
18	MP0000516_abnormal_urinary_system	1.57041980
19	MP0005367_renal/urinary_system_phenotyp	1.57041980
20	MP0002736_abnormal_nociception_after	1.55609935
21	MP0000778_abnormal_nervous_system	1.54847747
22	MP0003122_maternal_imprinting	1.48896429
23	MP0003942_abnormal_urinary_system	1.48092720
24	MP0005646_abnormal_pituitary_gland	1.46719997
25	MP0004133_heterotaxia	1.46426937
26	MP0002822_catalepsy	1.45741131
27	MP0001188_hyperpigmentation	1.45592326
28	MP0003121_genomic_imprinting	1.44156975
29	MP0002938_white_spotting	1.41920916
30	MP0003136_yellow_coat_color	1.38976790
31	MP0001905_abnormal_dopamine_level	1.37108988
32	MP0008932_abnormal_embryonic_tissue	1.36033872
33	MP0000751_myopathy	1.28242083
34	MP0005670_abnormal_white_adipose	1.24673151
35	MP0000750_abnormal_muscle_regeneration	1.24502605
36	MP0001542_abnormal_bone_strength	1.20541838
37	MP0003119_abnormal_digestive_system	1.20144951
38	MP0001968_abnormal_touch/_nociception	1.16813444
39	MP0004270_analgesia	1.16713274
40	MP0003786_premature_aging	1.16185545
41	MP0002751_abnormal_autonomic_nervous	1.15302350
42	MP0008058_abnormal_DNA_repair	1.14199914
43	MP0003011_delayed_dark_adaptation	1.13108646
44	MP0001984_abnormal_olfaction	1.12963971
45	MP0002102_abnormal_ear_morphology	1.12005097
46	MP0006036_abnormal_mitochondrial_physio	1.10335189
47	MP0008995_early_reproductive_senescence	1.10196977
48	MP0002557_abnormal_social/conspecific_i	1.09819605
49	MP0000534_abnormal_ureter_morphology	1.08885753
50	MP0005257_abnormal_intraocular_pressure	1.06133786
51	MP0002572_abnormal_emotion/affect_behav	1.03860871
52	MP0003635_abnormal_synaptic_transmissio	1.03560751
53	MP0000631_abnormal_neuroendocrine_gland	1.02971863
54	MP0003315_abnormal_perineum_morphology	1.02638825
55	MP0002734_abnormal_mechanical_nocicepti	1.02325839
56	MP0004858_abnormal_nervous_system	1.00838403
57	MP0002233_abnormal_nose_morphology	0.99428055
58	MP0001299_abnormal_eye_distance/	0.97297512
59	MP0001293_anophthalmia	0.96718313
60	MP0002272_abnormal_nervous_system	0.96641645
61	MP0003755_abnormal_palate_morphology	0.96459007
62	MP0002282_abnormal_trachea_morphology	0.95438043
63	MP0000955_abnormal_spinal_cord	0.95382162
64	MP0009053_abnormal_anal_canal	0.95343500
65	MP0003938_abnormal_ear_development	0.95210408
66	MP0002184_abnormal_innervation	0.95138499
67	MP0004272_abnormal_basement_membrane	0.92474134
68	MP0005187_abnormal_penis_morphology	0.92252644
69	MP0005171_absent_coat_pigmentation	0.92141996
70	MP0006035_abnormal_mitochondrial_morpho	0.91493693
71	MP0009745_abnormal_behavioral_response	0.90877016
72	MP0002177_abnormal_outer_ear	0.90702580
73	MP0000537_abnormal_urethra_morphology	0.90135789
74	MP0003787_abnormal_imprinting	0.90135241
75	MP0003937_abnormal_limbs/digits/tail_de	0.90038345
76	MP0009046_muscle_twitch	0.89041340
77	MP0003137_abnormal_impulse_conducting	0.88748664
78	MP0000749_muscle_degeneration	0.88262132
79	MP0002837_dystrophic_cardiac_calcinosis	0.87800174
80	MP0003861_abnormal_nervous_system	0.87781112
81	MP0000026_abnormal_inner_ear	0.87327124
82	MP0009250_abnormal_appendicular_skeleto	0.87017658
83	MP0000358_abnormal_cell_content/	0.86504969
84	MP0009780_abnormal_chondrocyte_physiolo	0.84850199
85	MP0002752_abnormal_somatic_nervous	0.84848138
86	MP0002733_abnormal_thermal_nociception	0.84510169
87	MP0006072_abnormal_retinal_apoptosis	0.83977340
88	MP0002063_abnormal_learning/memory/cond	0.82939853
89	MP0002697_abnormal_eye_size	0.82660135
90	MP0002882_abnormal_neuron_morphology	0.82086933
91	MP0003385_abnormal_body_wall	0.81942674
92	MP0005508_abnormal_skeleton_morphology	0.81144922
93	MP0004811_abnormal_neuron_physiology	0.80985875
94	MP0001970_abnormal_pain_threshold	0.79709319
95	MP0004147_increased_porphyrin_level	0.79485411
96	MP0002163_abnormal_gland_morphology	0.76564073
97	MP0002064_seizures	0.76502159
98	MP0000762_abnormal_tongue_morphology	0.76240893
99	MP0002152_abnormal_brain_morphology	0.75304157
100	MP0000647_abnormal_sebaceous_gland	0.74009984

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	4.03433372
2	Abnormal mitochondria in muscle tissue (HP:0008316)	3.86211936
3	Mitochondrial inheritance (HP:0001427)	3.56989022
4	Acute encephalopathy (HP:0006846)	3.52909564
5	Progressive macrocephaly (HP:0004481)	3.29471570
6	Hepatocellular necrosis (HP:0001404)	3.16849298
7	Increased CSF lactate (HP:0002490)	3.00066050
8	Renal Fanconi syndrome (HP:0001994)	2.98511594
9	Hepatic necrosis (HP:0002605)	2.98112060
10	Retinal dysplasia (HP:0007973)	2.67149265
11	Increased hepatocellular lipid droplets (HP:0006565)	2.61642474
12	Myokymia (HP:0002411)	2.59951251
13	Abnormality of glycolysis (HP:0004366)	2.56861650
14	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.56559036
15	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.56559036
16	Hypoplastic left heart (HP:0004383)	2.51117955
17	Increased serum pyruvate (HP:0003542)	2.43849995
18	Cerebral edema (HP:0002181)	2.37169605
19	Adrenal hypoplasia (HP:0000835)	2.34048527
20	Hand muscle atrophy (HP:0009130)	2.32279382
21	Exercise intolerance (HP:0003546)	2.28322788
22	Lipid accumulation in hepatocytes (HP:0006561)	2.26369505
23	Gait imbalance (HP:0002141)	2.26301912
24	Cerebral hypomyelination (HP:0006808)	2.23857651
25	Lactic acidosis (HP:0003128)	2.20732182
26	Poor suck (HP:0002033)	2.18195936
27	Medial flaring of the eyebrow (HP:0010747)	2.16269462
28	Congenital primary aphakia (HP:0007707)	2.14872363
29	Increased intramyocellular lipid droplets (HP:0012240)	2.14529722
30	Hypoplastic pelvis (HP:0008839)	2.13650858
31	Hyperglycinemia (HP:0002154)	2.12818977
32	Abnormality of the umbilical cord (HP:0010881)	2.12021828
33	Nephrogenic diabetes insipidus (HP:0009806)	2.08731545
34	Delayed CNS myelination (HP:0002188)	2.08263129
35	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.06925851
36	Abnormal umbilical cord blood vessels (HP:0011403)	2.06796731
37	Single umbilical artery (HP:0001195)	2.06796731
38	Abnormality of the fetal cardiovascular system (HP:0010948)	2.06796731
39	Degeneration of anterior horn cells (HP:0002398)	2.06412771
40	Abnormality of the anterior horn cell (HP:0006802)	2.06412771
41	Respiratory failure (HP:0002878)	2.05274051
42	Congenital malformation of the right heart (HP:0011723)	2.04791612
43	Double outlet right ventricle (HP:0001719)	2.04791612
44	Polyphagia (HP:0002591)	2.04126878
45	Hypoplastic heart (HP:0001961)	2.01012850
46	Opisthotonus (HP:0002179)	1.98354761
47	Concave nail (HP:0001598)	1.97261978
48	Increased serum lactate (HP:0002151)	1.92970001
49	Abnormal gallbladder physiology (HP:0012438)	1.92087440
50	Cholecystitis (HP:0001082)	1.92087440
51	Sclerocornea (HP:0000647)	1.91193932
52	Down-sloping shoulders (HP:0200021)	1.90465424
53	Emotional lability (HP:0000712)	1.86797451
54	Upper limb amyotrophy (HP:0009129)	1.86072017
55	Distal upper limb amyotrophy (HP:0007149)	1.86072017
56	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.85238586
57	Type I transferrin isoform profile (HP:0003642)	1.83945033
58	Microretrognathia (HP:0000308)	1.83777196
59	Testicular atrophy (HP:0000029)	1.80994639
60	Methylmalonic aciduria (HP:0012120)	1.80855311
61	Increased muscle lipid content (HP:0009058)	1.79127078
62	Severe muscular hypotonia (HP:0006829)	1.75854276
63	Upper limb muscle weakness (HP:0003484)	1.75591921
64	Methylmalonic acidemia (HP:0002912)	1.75569490
65	X-linked dominant inheritance (HP:0001423)	1.75259278
66	Exertional dyspnea (HP:0002875)	1.74927776
67	Hypokinesia (HP:0002375)	1.72409670
68	Occipital encephalocele (HP:0002085)	1.72096473
69	Abnormal number of erythroid precursors (HP:0012131)	1.70238645
70	Optic disc pallor (HP:0000543)	1.69695552
71	True hermaphroditism (HP:0010459)	1.65124874
72	Leukodystrophy (HP:0002415)	1.64908020
73	Delayed gross motor development (HP:0002194)	1.64566105
74	Muscle fiber atrophy (HP:0100295)	1.59306850
75	Abnormality of dentin (HP:0010299)	1.58928943
76	Hydroureter (HP:0000072)	1.57338719
77	Microvesicular hepatic steatosis (HP:0001414)	1.56816121
78	Abnormality of the aortic arch (HP:0012303)	1.56209907
79	Abnormal protein glycosylation (HP:0012346)	1.55084104
80	Abnormal glycosylation (HP:0012345)	1.55084104
81	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.55084104
82	Abnormal protein N-linked glycosylation (HP:0012347)	1.55084104
83	Aplasia/hypoplasia of the uterus (HP:0008684)	1.54870840
84	Renal dysplasia (HP:0000110)	1.54367433
85	Abnormalities of placenta or umbilical cord (HP:0001194)	1.53311829
86	Hyperthyroidism (HP:0000836)	1.52851239
87	Abnormal number of incisors (HP:0011064)	1.52634014
88	Dental crowding (HP:0000678)	1.52284895
89	Preaxial hand polydactyly (HP:0001177)	1.50932739
90	Broad distal phalanx of finger (HP:0009836)	1.50430617
91	Abnormality of renal resorption (HP:0011038)	1.50173629
92	Postnatal microcephaly (HP:0005484)	1.49579630
93	Cortical dysplasia (HP:0002539)	1.49216668
94	Abnormal hemoglobin (HP:0011902)	1.49182114
95	Abnormality of cells of the erythroid lineage (HP:0012130)	1.48750950
96	Vaginal atresia (HP:0000148)	1.48282271
97	Optic nerve coloboma (HP:0000588)	1.48129503
98	Genital tract atresia (HP:0001827)	1.47971657
99	Lethargy (HP:0001254)	1.47833375
100	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.47724998

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	VRK2	4.59475214
2	TESK1	3.66829749
3	LIMK1	3.26102442
4	NME2	3.08001602
5	BCKDK	2.79506775
6	TESK2	2.49475436
7	STK16	2.22314318
8	TRIM28	2.14433269
9	MAP2K7	2.07529939
10	MARK1	2.01041677
11	CSNK1G3	1.96996746
12	BUB1	1.90177152
13	PIM2	1.88684756
14	DYRK2	1.74836801
15	CSNK1G2	1.69388563
16	EPHA2	1.67478701
17	CSNK1A1L	1.61731467
18	PRKD3	1.53103192
19	ARAF	1.52580089
20	LMTK2	1.50209105
21	EPHB2	1.49624644
22	CSNK1G1	1.44399436
23	DAPK1	1.42365500
24	NEK1	1.42120325
25	SRPK1	1.37843608
26	CASK	1.36292708
27	BRSK1	1.32773896
28	MAP4K2	1.26820549
29	MINK1	1.21359086
30	WNK3	1.20308103
31	PBK	1.15447738
32	BCR	1.15361405
33	ABL2	1.13398296
34	ILK	1.11901606
35	EIF2AK1	1.09822459
36	EPHA4	1.06674143
37	DYRK3	1.06597063
38	VRK1	1.04018542
39	MUSK	1.01667729
40	NME1	0.97828642
41	PAK6	0.96871383
42	TNIK	0.96833281
43	MAP3K4	0.95797658
44	CCNB1	0.95081411
45	MAP3K12	0.92535858
46	PDK2	0.92372046
47	AURKA	0.89691428
48	DAPK3	0.88584914
49	CDK14	0.83316443
50	PHKG1	0.82949667
51	PHKG2	0.82949667
52	CDK19	0.82081599
53	PTK2	0.81400545
54	PLK3	0.78744596
55	GRK5	0.77333615
56	NUAK1	0.77021937
57	PAK4	0.76750868
58	CDK18	0.76364731
59	PLK2	0.75534522
60	MYLK	0.75169816
61	SIK3	0.74827677
62	CDK11A	0.73878937
63	PRKCI	0.71810154
64	CDK15	0.71242517
65	BRAF	0.70491368
66	PAK3	0.69903069
67	PRKCG	0.68509566
68	PINK1	0.68232773
69	CAMK2G	0.64910758
70	WEE1	0.64905204
71	PRKD2	0.63243956
72	CDC7	0.60834881
73	CDK8	0.60672167
74	MAP3K11	0.60274301
75	LRRK2	0.59322014
76	PLK1	0.59261191
77	DAPK2	0.58495984
78	UHMK1	0.56182466
79	CAMK2B	0.54866153
80	TAF1	0.54603693
81	AKT2	0.53465750
82	NTRK1	0.53161013
83	CAMK2D	0.51442721
84	ERBB4	0.50517391
85	PAK1	0.49487531
86	INSRR	0.47135601
87	KDR	0.46567146
88	CDK7	0.45634110
89	CSNK1A1	0.45344584
90	MAPK15	0.43386604
91	PRKCE	0.42988578
92	AURKB	0.42884118
93	MAPKAPK5	0.42787088
94	SIK1	0.42710370
95	MAPKAPK3	0.41505750
96	MAPK13	0.39821493
97	DYRK1B	0.39609271
98	ROCK2	0.39454582
99	FER	0.39056640
100	CDK5	0.38823780

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	3.33890378
2	Parkinsons disease_Homo sapiens_hsa05012	2.94546561
3	Proteasome_Homo sapiens_hsa03050	2.73245108
4	Ribosome_Homo sapiens_hsa03010	2.43417130
5	Sulfur relay system_Homo sapiens_hsa04122	2.37522720
6	Fatty acid elongation_Homo sapiens_hsa00062	2.31056231
7	Huntingtons disease_Homo sapiens_hsa05016	2.18945399
8	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.99970184
9	RNA polymerase_Homo sapiens_hsa03020	1.97602874
10	Folate biosynthesis_Homo sapiens_hsa00790	1.96760810
11	Base excision repair_Homo sapiens_hsa03410	1.94782422
12	Alzheimers disease_Homo sapiens_hsa05010	1.94264035
13	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.93638365
14	Protein export_Homo sapiens_hsa03060	1.86979483
15	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.78777516
16	Cardiac muscle contraction_Homo sapiens_hsa04260	1.61036943
17	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.56491601
18	Pyrimidine metabolism_Homo sapiens_hsa00240	1.51170321
19	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.50123399
20	DNA replication_Homo sapiens_hsa03030	1.46399372
21	Vibrio cholerae infection_Homo sapiens_hsa05110	1.45555380
22	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.43652985
23	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.43349244
24	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.43019632
25	Pyruvate metabolism_Homo sapiens_hsa00620	1.40628651
26	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.38963087
27	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.38009277
28	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.36521620
29	Glutathione metabolism_Homo sapiens_hsa00480	1.34414476
30	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.29720868
31	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.27670900
32	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.27658949
33	Mismatch repair_Homo sapiens_hsa03430	1.23370973
34	Carbon metabolism_Homo sapiens_hsa01200	1.22203708
35	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.15562942
36	Spliceosome_Homo sapiens_hsa03040	1.13987029
37	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.13330433
38	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.12228302
39	Steroid biosynthesis_Homo sapiens_hsa00100	1.10295023
40	Collecting duct acid secretion_Homo sapiens_hsa04966	1.09289079
41	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.07252224
42	Pentose phosphate pathway_Homo sapiens_hsa00030	1.01815612
43	Propanoate metabolism_Homo sapiens_hsa00640	1.01165921
44	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.00793849
45	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.00436557
46	Nucleotide excision repair_Homo sapiens_hsa03420	0.98742270
47	Purine metabolism_Homo sapiens_hsa00230	0.92720625
48	Arginine and proline metabolism_Homo sapiens_hsa00330	0.91910050
49	Basal transcription factors_Homo sapiens_hsa03022	0.87763590
50	Cocaine addiction_Homo sapiens_hsa05030	0.86347350
51	Homologous recombination_Homo sapiens_hsa03440	0.85909640
52	Basal cell carcinoma_Homo sapiens_hsa05217	0.85208203
53	Metabolic pathways_Homo sapiens_hsa01100	0.84627146
54	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.83570974
55	Galactose metabolism_Homo sapiens_hsa00052	0.83530203
56	beta-Alanine metabolism_Homo sapiens_hsa00410	0.83504957
57	Fanconi anemia pathway_Homo sapiens_hsa03460	0.81422512
58	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.81141016
59	Butanoate metabolism_Homo sapiens_hsa00650	0.80325130
60	RNA transport_Homo sapiens_hsa03013	0.79087158
61	Nicotine addiction_Homo sapiens_hsa05033	0.78841414
62	Peroxisome_Homo sapiens_hsa04146	0.77934001
63	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.74791470
64	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.73173415
65	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.69969018
66	Hippo signaling pathway_Homo sapiens_hsa04390	0.68337654
67	Regulation of autophagy_Homo sapiens_hsa04140	0.66534410
68	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.65686399
69	One carbon pool by folate_Homo sapiens_hsa00670	0.64689463
70	Selenocompound metabolism_Homo sapiens_hsa00450	0.63389099
71	GABAergic synapse_Homo sapiens_hsa04727	0.59065362
72	Sulfur metabolism_Homo sapiens_hsa00920	0.58459226
73	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.58253057
74	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.56350862
75	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.56097672
76	Phenylalanine metabolism_Homo sapiens_hsa00360	0.55702819
77	RNA degradation_Homo sapiens_hsa03018	0.54618923
78	Axon guidance_Homo sapiens_hsa04360	0.54103121
79	Dopaminergic synapse_Homo sapiens_hsa04728	0.53227831
80	Phototransduction_Homo sapiens_hsa04744	0.51856522
81	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.50612237
82	Tyrosine metabolism_Homo sapiens_hsa00350	0.50334423
83	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.47814368
84	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.45675714
85	Insulin secretion_Homo sapiens_hsa04911	0.42982973
86	Fatty acid metabolism_Homo sapiens_hsa01212	0.42269358
87	Amphetamine addiction_Homo sapiens_hsa05031	0.40649527
88	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.38725446
89	Wnt signaling pathway_Homo sapiens_hsa04310	0.36738360
90	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.36495765
91	Oocyte meiosis_Homo sapiens_hsa04114	0.35787672
92	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.35702134
93	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.35575752
94	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.30519856
95	Tight junction_Homo sapiens_hsa04530	0.30320437
96	Melanogenesis_Homo sapiens_hsa04916	0.30285846
97	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.30119348
98	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.29750065
99	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.29712230
100	Non-homologous end-joining_Homo sapiens_hsa03450	0.28623311

FAM127B

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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