FAM129A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the family with sequence similarity 129 protein family. This gene is highly expressed in several cancer cells and may serve as a prognostic marker for certain cancers. The encoded protein may play a role in regulating p53-mediated apoptosis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1detection of molecule of bacterial origin (GO:0032490)5.50095811
2negative regulation of cell killing (GO:0031342)5.41612086
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.41612086
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.81231808
5NIK/NF-kappaB signaling (GO:0038061)4.69821249
6antigen processing and presentation of endogenous antigen (GO:0019883)4.47925911
7detection of external biotic stimulus (GO:0098581)4.39801376
8microglial cell activation (GO:0001774)4.33161847
9detection of other organism (GO:0098543)4.32920095
10negative regulation of interleukin-12 production (GO:0032695)4.27750501
11antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.27494341
12antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.27494341
13positive regulation of natural killer cell differentiation (GO:0032825)3.99147408
14macrophage activation (GO:0042116)3.91121437
15response to interleukin-15 (GO:0070672)3.83448448
16detection of biotic stimulus (GO:0009595)3.80885678
17growth hormone receptor signaling pathway (GO:0060396)3.79081042
18neutrophil mediated immunity (GO:0002446)3.75461702
19regulation of interleukin-12 biosynthetic process (GO:0045075)3.74082531
20detection of bacterium (GO:0016045)3.72035984
21response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.69783611
22response to host (GO:0075136)3.69783611
23response to host defenses (GO:0052200)3.69783611
24negative regulation of lymphocyte mediated immunity (GO:0002707)3.69552219
25regulation of dendritic cell antigen processing and presentation (GO:0002604)3.67413899
26neutrophil activation involved in immune response (GO:0002283)3.65715954
27negative regulation of T cell mediated immunity (GO:0002710)3.55244543
28cellular response to interleukin-15 (GO:0071350)3.50973541
29positive regulation of interferon-alpha production (GO:0032727)3.46498224
30production of molecular mediator involved in inflammatory response (GO:0002532)3.44365720
31positive regulation of gamma-delta T cell activation (GO:0046645)3.43089415
32regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.42165054
33cellular response to growth hormone stimulus (GO:0071378)3.39933220
34germinal center formation (GO:0002467)3.38942543
35myeloid cell activation involved in immune response (GO:0002275)3.35277504
36regulation of interferon-alpha production (GO:0032647)3.34527418
37negative thymic T cell selection (GO:0045060)3.34305530
38response to muramyl dipeptide (GO:0032495)3.28354811
39myeloid dendritic cell differentiation (GO:0043011)3.27847891
40regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.24969084
41neutrophil activation (GO:0042119)3.24724734
42modulation by symbiont of host immune response (GO:0052553)3.24273469
43positive regulation by symbiont of host defense response (GO:0052509)3.24273469
44modulation by symbiont of host defense response (GO:0052031)3.24273469
45modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.24273469
46modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.24273469
47positive regulation by organism of defense response of other organism involved in symbiotic interact3.24273469
48regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.22845888
49B cell receptor signaling pathway (GO:0050853)3.21939320
50myeloid leukocyte mediated immunity (GO:0002444)3.21328697
51regulation of interferon-beta biosynthetic process (GO:0045357)3.20705628
52negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.19863739
53respiratory burst (GO:0045730)3.19289785
54regulation of T cell tolerance induction (GO:0002664)3.19115890
55natural killer cell mediated cytotoxicity (GO:0042267)3.18246248
56natural killer cell mediated immunity (GO:0002228)3.18246248
57negative regulation of leukocyte mediated immunity (GO:0002704)3.17861505
58regulation of RIG-I signaling pathway (GO:0039535)3.17621666
59positive regulation of antigen processing and presentation (GO:0002579)3.15921349
60negative T cell selection (GO:0043383)3.12922943
61granulocyte activation (GO:0036230)3.11162018
62positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.10848879
63cellular response to interferon-alpha (GO:0035457)3.10773540
64defense response to protozoan (GO:0042832)3.09844204
65JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.03964429
66negative regulation of T-helper cell differentiation (GO:0045623)3.03756973
67negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.03756973
68leukocyte migration involved in inflammatory response (GO:0002523)3.02828307
69regulation of T-helper 1 cell differentiation (GO:0045625)2.99112771
70dendritic cell migration (GO:0036336)2.97716607
71dendritic cell differentiation (GO:0097028)2.96883358
72hepatocyte apoptotic process (GO:0097284)2.95799328
73negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.95776169
74myeloid dendritic cell activation (GO:0001773)2.95586980
75immunoglobulin mediated immune response (GO:0016064)2.95346051
76regulation of mast cell degranulation (GO:0043304)2.94886192
77positive regulation of interleukin-12 production (GO:0032735)2.94852741
78response to type I interferon (GO:0034340)2.94093695
79positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.92435244
80cellular response to type I interferon (GO:0071357)2.91139881
81type I interferon signaling pathway (GO:0060337)2.91139881
82interferon-gamma-mediated signaling pathway (GO:0060333)2.90799264
83tolerance induction (GO:0002507)2.90713928
84Arp2/3 complex-mediated actin nucleation (GO:0034314)2.88463397
85response to peptidoglycan (GO:0032494)2.86332466
86regulation of antigen processing and presentation (GO:0002577)2.83409043
87leukocyte aggregation (GO:0070486)2.83368911
88positive regulation of mast cell activation (GO:0033005)2.82667876
89dendritic cell chemotaxis (GO:0002407)2.82532436
90positive thymic T cell selection (GO:0045059)2.80599936
91negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.79821702
92cytokine secretion (GO:0050663)2.78103344
93T-helper 1 type immune response (GO:0042088)2.77077205
94cell adhesion mediated by integrin (GO:0033627)2.76903820
95regulation of mast cell activation involved in immune response (GO:0033006)2.76855536
96regulation of T-helper 2 cell differentiation (GO:0045628)2.76259129
97response to protozoan (GO:0001562)2.75636392
98regulation of macrophage cytokine production (GO:0010935)2.75319648
99response to interferon-alpha (GO:0035455)2.74877851
100regulation of B cell differentiation (GO:0045577)2.71889159
101regulation of mast cell activation (GO:0033003)2.70802070
102myeloid leukocyte activation (GO:0002274)2.69734004
103regulation of interleukin-12 production (GO:0032655)2.69320477
104regulation of myeloid leukocyte mediated immunity (GO:0002886)2.68692103
105positive regulation of B cell differentiation (GO:0045579)2.67662905
106positive regulation of tolerance induction (GO:0002645)2.67273243
107positive regulation of cellular amide metabolic process (GO:0034250)2.66368046
108negative regulation of adaptive immune response (GO:0002820)2.65724948
109regulation of natural killer cell differentiation (GO:0032823)2.65506136
110leukocyte degranulation (GO:0043299)2.65442471
111T-helper cell differentiation (GO:0042093)2.64141756
112CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.64141756
113thymic T cell selection (GO:0045061)2.63223809
114regulation of tolerance induction (GO:0002643)2.61360335
115regulation of gamma-delta T cell differentiation (GO:0045586)2.60126736
116antigen processing and presentation via MHC class Ib (GO:0002475)2.60015397
117positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.59657265
118positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.59227245
119regulation of alpha-beta T cell proliferation (GO:0046640)2.58533102
120positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.56184905
121macrophage activation involved in immune response (GO:0002281)2.55106417
122regulation of B cell receptor signaling pathway (GO:0050855)2.54998725
123regulation of gamma-delta T cell activation (GO:0046643)2.54809794
124regulation of necroptotic process (GO:0060544)2.54439521
125B cell mediated immunity (GO:0019724)2.54216413
126positive regulation of interferon-beta production (GO:0032728)2.53256420
127T cell activation involved in immune response (GO:0002286)2.51690817
128regulation of response to interferon-gamma (GO:0060330)2.51668225
129cellular extravasation (GO:0045123)2.51234842
130regulation of hypersensitivity (GO:0002883)2.49482179
131regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.48365974
132positive regulation of interleukin-2 production (GO:0032743)2.47312920
133leukocyte cell-cell adhesion (GO:0007159)2.46497836
134apoptotic cell clearance (GO:0043277)2.45013476
135negative regulation of lipid storage (GO:0010888)2.44936579
136interferon-gamma secretion (GO:0072643)2.44236229
137positive regulation of natural killer cell activation (GO:0032816)2.44168778
138positive regulation of alpha-beta T cell proliferation (GO:0046641)2.43529675
139regulation of type I interferon-mediated signaling pathway (GO:0060338)2.42823993
140lipopolysaccharide-mediated signaling pathway (GO:0031663)2.42127301
141positive regulation of p38MAPK cascade (GO:1900745)2.42044760
142positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.41732483
143pinocytosis (GO:0006907)2.41283357
144regulation of activation of Janus kinase activity (GO:0010533)2.39737551
145positive regulation of macrophage differentiation (GO:0045651)2.39005536
146natural killer cell activation (GO:0030101)2.38993130
147positive regulation of T-helper cell differentiation (GO:0045624)2.37718383
148regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.37191510
149natural killer cell differentiation (GO:0001779)2.36933504
150T cell migration (GO:0072678)2.36907007
151positive regulation of T-helper 1 type immune response (GO:0002827)2.36450485
152response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.35078153
153response to host immune response (GO:0052572)2.35078153
154positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.34963128

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.96585045
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.92688381
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.33116212
4TP63_17297297_ChIP-ChIP_HaCaT_Human4.29910584
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.85303471
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.75515864
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.53435416
8STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.26852725
9IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.21331242
10IRF8_27001747_Chip-Seq_BMDM_Mouse3.02323653
11* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.95587767
12BP1_19119308_ChIP-ChIP_Hs578T_Human2.92504904
13STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.90625406
14IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.85147771
15* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.80074842
16NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.69484318
17MYB_21317192_ChIP-Seq_ERMYB_Mouse2.68110207
18MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.48186829
19* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.32848796
20STAT4_19710469_ChIP-ChIP_TH1__Mouse2.23451968
21TRIM28_21343339_ChIP-Seq_HEK293_Human2.14988937
22RARG_19884340_ChIP-ChIP_MEFs_Mouse2.05220588
23RUNX_20019798_ChIP-Seq_JUKART_Human2.04001074
24NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.00509026
25MYB_26560356_Chip-Seq_TH2_Human1.95906431
26BRD4_27068464_Chip-Seq_AML-cells_Mouse1.90627681
27* MAF_26560356_Chip-Seq_TH1_Human1.90294977
28SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.87224800
29SMAD_19615063_ChIP-ChIP_OVARY_Human1.85214272
30TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.81875535
31CLOCK_20551151_ChIP-Seq_293T_Human1.78734983
32STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.74854759
33FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.71449348
34BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.69288800
35MYB_26560356_Chip-Seq_TH1_Human1.63043450
36CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.61366540
37GATA1_19941827_ChIP-Seq_MEL_Mouse1.58290139
38ELK3_25401928_ChIP-Seq_HUVEC_Human1.55519438
39GATA2_21666600_ChIP-Seq_HMVEC_Human1.55443663
40TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.55264932
41VDR_24787735_ChIP-Seq_THP-1_Human1.54813984
42VDR_24763502_ChIP-Seq_THP-1_Human1.54403735
43SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.53157694
44* SPI1_23547873_ChIP-Seq_NB4_Human1.52583775
45RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.45851599
46CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.43849336
47VDR_21846776_ChIP-Seq_THP-1_Human1.43131408
48SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.42382205
49SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.42382205
50ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.40589837
51TCF7_22412390_ChIP-Seq_EML_Mouse1.40480328
52TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.39224368
53* PU_27001747_Chip-Seq_BMDM_Mouse1.39223770
54* SPI1_23127762_ChIP-Seq_K562_Human1.38993891
55* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.35257408
56LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.31832277
57RUNX1_22412390_ChIP-Seq_EML_Mouse1.31071673
58ESR1_21235772_ChIP-Seq_MCF-7_Human1.29949101
59KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.29028806
60GATA1_19941826_ChIP-Seq_K562_Human1.28276829
61PPAR_26484153_Chip-Seq_NCI-H1993_Human1.27910944
62UTX_26944678_Chip-Seq_JUKART_Human1.27766770
63* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.26892734
64GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.26555773
65* GATA3_27048872_Chip-Seq_THYMUS_Human1.26420077
66LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.25765304
67SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.23831478
68PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.22746180
69* FOXO3_23340844_ChIP-Seq_DLD1_Human1.22180361
70GATA1_22025678_ChIP-Seq_K562_Human1.19992316
71* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.19921272
72* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.19011874
73GATA2_19941826_ChIP-Seq_K562_Human1.18218272
74* CJUN_26792858_Chip-Seq_BT549_Human1.17847986
75CDX2_19796622_ChIP-Seq_MESCs_Mouse1.17733716
76RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.17481256
77NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.17405854
78SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.16596369
79* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.16596316
80KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.15477596
81CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.14356646
82JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.13644004
83KDM2B_26808549_Chip-Seq_DND41_Human1.11358452
84KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.11047323
85HIF1A_21447827_ChIP-Seq_MCF-7_Human1.10853942
86SCL_19346495_ChIP-Seq_HPC-7_Human1.09988733
87ESR1_20079471_ChIP-ChIP_T-47D_Human1.09713139
88E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.09637083
89MYC_22102868_ChIP-Seq_BL_Human1.08257300
90ESR2_21235772_ChIP-Seq_MCF-7_Human1.06727843
91GATA1_19941827_ChIP-Seq_MEL86_Mouse1.05942033
92VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.05766632
93JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.05571725
94* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.05420475
95STAT6_21828071_ChIP-Seq_BEAS2B_Human1.04569854
96MAF_26560356_Chip-Seq_TH2_Human1.01761982
97BRD4_25478319_ChIP-Seq_HGPS_Human1.01613375
98ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.01004208
99ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.00774720
100SOX2_20726797_ChIP-Seq_SW620_Human1.00491117
101* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.99743210
102CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99601056
103UBF1/2_26484160_Chip-Seq_HMECs_Human0.99242877
104RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.98441810
105PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98072237
106GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.96948263
107GATA3_26560356_Chip-Seq_TH2_Human0.96601590
108THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.93235115
109RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93155466
110GATA1_22383799_ChIP-Seq_G1ME_Mouse0.92872085
111KDM2B_26808549_Chip-Seq_JURKAT_Human0.89434608
112GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89177963
113* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.88675777
114SALL4_18804426_ChIP-ChIP_XEN_Mouse0.87538570
115P63_26484246_Chip-Seq_KERATINOCYTES_Human0.86697333
116RACK7_27058665_Chip-Seq_MCF-7_Human0.85879401
117* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.85587805
118SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.84384956
119* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.83961298
120TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.82457194
121PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.82410482
122BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.81424147
123TBX20_22328084_ChIP-Seq_HEART_Mouse0.81403758
124TBX20_22080862_ChIP-Seq_HEART_Mouse0.81403758
125NCOR1_26117541_ChIP-Seq_K562_Human0.81255383
126CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.80109952
127SMRT_27268052_Chip-Seq_Bcells_Human0.78037093
128FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.78000682
129VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.73819765
130KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.72604680
131FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.71279973
132TP53_16413492_ChIP-PET_HCT116_Human0.70335589
133SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.69586634

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen3.43661466
2MP0001835_abnormal_antigen_presentation3.28922581
3MP0000685_abnormal_immune_system2.81529227
4MP0003436_decreased_susceptibility_to2.70931148
5MP0005451_abnormal_body_composition2.66103951
6MP0002166_altered_tumor_susceptibility2.44088027
7MP0009785_altered_susceptibility_to2.41652159
8MP0005387_immune_system_phenotype2.41421296
9MP0001790_abnormal_immune_system2.41421296
10MP0004510_myositis2.34322757
11MP0003724_increased_susceptibility_to2.34202074
12MP0008260_abnormal_autophagy2.31247949
13MP0002148_abnormal_hypersensitivity_rea2.27439619
14MP0003303_peritoneal_inflammation2.24198706
15MP0002138_abnormal_hepatobiliary_system2.23366374
16MP0005671_abnormal_response_to2.17350789
17MP0005000_abnormal_immune_tolerance2.15788937
18MP0002254_reproductive_system_inflammat2.14753595
19MP0003705_abnormal_hypodermis_morpholog2.14440017
20MP0003300_gastrointestinal_ulcer2.09878094
21MP0002006_tumorigenesis2.08638879
22MP0002419_abnormal_innate_immunity2.08135104
23MP0005275_abnormal_skin_tensile2.02599110
24MP0003566_abnormal_cell_adhesion1.95598351
25MP0002452_abnormal_antigen_presenting1.95337642
26MP0001800_abnormal_humoral_immune1.93574269
27MP0005025_abnormal_response_to1.91455624
28MP0004381_abnormal_hair_follicle1.83607480
29MP0001533_abnormal_skeleton_physiology1.80663892
30MP0006082_CNS_inflammation1.80206927
31MP0010352_gastrointestinal_tract_polyps1.79306905
32MP0001958_emphysema1.78762397
33MP0002723_abnormal_immune_serum1.78242257
34MP0003448_altered_tumor_morphology1.73481734
35MP0009278_abnormal_bone_marrow1.72798384
36MP0001819_abnormal_immune_cell1.72625907
37MP0002877_abnormal_melanocyte_morpholog1.70977391
38MP0001348_abnormal_lacrimal_gland1.70526593
39MP0002420_abnormal_adaptive_immunity1.70021025
40MP0005076_abnormal_cell_differentiation1.69744614
41MP0003172_abnormal_lysosome_physiology1.68037002
42MP0004947_skin_inflammation1.65905627
43MP0002405_respiratory_system_inflammati1.63890456
44MP0003646_muscle_fatigue1.61153378
45MP0010155_abnormal_intestine_physiology1.54474494
46MP0003279_aneurysm1.53961393
47MP0004883_abnormal_blood_vessel1.53141064
48MP0002332_abnormal_exercise_endurance1.51689429
49MP0003656_abnormal_erythrocyte_physiolo1.51356255
50MP0000858_altered_metastatic_potential1.51007586
51MP0004484_altered_response_of1.50964322
52MP0004084_abnormal_cardiac_muscle1.49822656
53MP0003091_abnormal_cell_migration1.48315185
54MP0001853_heart_inflammation1.48213817
55MP0005503_abnormal_tendon_morphology1.47224511
56MP0002009_preneoplasia1.43908685
57MP0001873_stomach_inflammation1.43521470
58MP0005310_abnormal_salivary_gland1.41902697
59MP0005023_abnormal_wound_healing1.40973829
60MP0004130_abnormal_muscle_cell1.40676096
61MP0003221_abnormal_cardiomyocyte_apopto1.39462012
62MP0005058_abnormal_lysosome_morphology1.36939354
63MP0005397_hematopoietic_system_phenotyp1.36813005
64MP0001545_abnormal_hematopoietic_system1.36813005
65MP0001845_abnormal_inflammatory_respons1.36349064
66MP0003045_fibrosis1.35611210
67MP0002933_joint_inflammation1.35256618
68MP0002998_abnormal_bone_remodeling1.34602423
69MP0000343_altered_response_to1.33504553
70MP0000716_abnormal_immune_system1.28310609
71MP0002398_abnormal_bone_marrow1.24508324
72MP0003453_abnormal_keratinocyte_physiol1.20948913
73MP0000015_abnormal_ear_pigmentation1.20913936
74MP0004036_abnormal_muscle_relaxation1.20096597
75MP0006054_spinal_hemorrhage1.18547819
76MP0009333_abnormal_splenocyte_physiolog1.18102750
77MP0003763_abnormal_thymus_physiology1.17960477
78MP0002132_abnormal_respiratory_system1.17031656
79MP0003828_pulmonary_edema1.16243072
80MP0003075_altered_response_to1.15648093
81MP0009764_decreased_sensitivity_to1.12633527
82MP0005464_abnormal_platelet_physiology1.12433036
83MP0000703_abnormal_thymus_morphology1.11959400
84MP0005390_skeleton_phenotype1.11027363
85MP0008469_abnormal_protein_level1.07217391
86MP0000767_abnormal_smooth_muscle1.06290842
87MP0005623_abnormal_meninges_morphology1.06170068
88MP0004808_abnormal_hematopoietic_stem1.05380806
89MP0000749_muscle_degeneration1.04279020
90MP0005075_abnormal_melanosome_morpholog1.02958051
91MP0002429_abnormal_blood_cell1.02501269
92MP0002277_abnormal_respiratory_mucosa1.01422907
93MP0003191_abnormal_cellular_cholesterol1.00483513
94MP0010234_abnormal_vibrissa_follicle1.00377714
95MP0000569_abnormal_digit_pigmentation1.00019870
96MP0002396_abnormal_hematopoietic_system0.98995277
97MP0002060_abnormal_skin_morphology0.98957335
98MP0002722_abnormal_immune_system0.98213525
99MP0008004_abnormal_stomach_pH0.97565381
100MP0000689_abnormal_spleen_morphology0.97198981
101MP0005166_decreased_susceptibility_to0.96910643
102MP0010307_abnormal_tumor_latency0.95979074
103MP0003690_abnormal_glial_cell0.95668127
104MP0000249_abnormal_blood_vessel0.95234925
105MP0000733_abnormal_muscle_development0.94017472
106MP0003183_abnormal_peptide_metabolism0.93563506
107MP0005164_abnormal_response_to0.92346186
108MP0000751_myopathy0.90922187
109MP0002972_abnormal_cardiac_muscle0.89859549
110MP0004272_abnormal_basement_membrane0.88040122
111MP0000371_diluted_coat_color0.86861585
112MP0009763_increased_sensitivity_to0.85974475
113MP0001879_abnormal_lymphatic_vessel0.85136917
114MP0001542_abnormal_bone_strength0.84353562
115MP0001346_abnormal_lacrimal_gland0.83521742
116MP0004185_abnormal_adipocyte_glucose0.83101667
117MP0001243_abnormal_dermal_layer0.82561169
118MP0005167_abnormal_blood-brain_barrier0.82294670
119MP0002295_abnormal_pulmonary_circulatio0.81524502
120MP0003795_abnormal_bone_structure0.80811704
121MP0000465_gastrointestinal_hemorrhage0.80604885
122MP0001881_abnormal_mammary_gland0.80355919
123MP0005330_cardiomyopathy0.79733480
124MP0010630_abnormal_cardiac_muscle0.77064668
125MP0009840_abnormal_foam_cell0.76563509
126MP0004087_abnormal_muscle_fiber0.76372462
127MP0003866_abnormal_defecation0.75817582
128MP0000604_amyloidosis0.74912803
129MP0005174_abnormal_tail_pigmentation0.74226590
130MP0002163_abnormal_gland_morphology0.74025808
131MP0001851_eye_inflammation0.73925759
132MP0005385_cardiovascular_system_phenoty0.72762641
133MP0001544_abnormal_cardiovascular_syste0.72762641
134MP0000627_abnormal_mammary_gland0.71806803

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)4.76278010
2Myositis (HP:0100614)4.11068799
3Orchitis (HP:0100796)4.06486293
4Recurrent abscess formation (HP:0002722)3.95690425
5Osteolytic defects of the phalanges of the hand (HP:0009771)3.79423049
6Osteolytic defects of the hand bones (HP:0009699)3.79423049
7T lymphocytopenia (HP:0005403)3.74012313
8Optic neuritis (HP:0100653)3.67757431
9Retrobulbar optic neuritis (HP:0100654)3.67757431
10Recurrent bacterial skin infections (HP:0005406)3.62109177
11Aortic aneurysm (HP:0004942)3.60874753
12Peritonitis (HP:0002586)3.48055619
13Aortic dissection (HP:0002647)3.38118038
14Premature rupture of membranes (HP:0001788)3.34678493
15Autoimmune thrombocytopenia (HP:0001973)3.34675891
16Elevated erythrocyte sedimentation rate (HP:0003565)3.30530305
17Protrusio acetabuli (HP:0003179)3.28858656
18Recurrent fungal infections (HP:0002841)3.23494273
19Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.16558152
20Meningitis (HP:0001287)3.12063700
21Hematochezia (HP:0002573)3.09624454
22Abnormality of macrophages (HP:0004311)3.06299918
23Cerebral aneurysm (HP:0004944)3.02940412
24Muscle fiber splitting (HP:0003555)3.01322707
25Recurrent gram-negative bacterial infections (HP:0005420)2.98785792
26Arterial thrombosis (HP:0004420)2.98361799
27Encephalitis (HP:0002383)2.97760855
28Vertebral compression fractures (HP:0002953)2.91069055
29Urticaria (HP:0001025)2.90238864
30Hyporeflexia of lower limbs (HP:0002600)2.90111553
31Myocardial infarction (HP:0001658)2.89717792
32Cervical subluxation (HP:0003308)2.84077392
33Increased density of long bones (HP:0006392)2.82077390
34Interstitial pulmonary disease (HP:0006530)2.75605393
35Increased IgM level (HP:0003496)2.73718895
36Ankle contracture (HP:0006466)2.71361424
37Difficulty running (HP:0009046)2.66454288
38Vasculitis (HP:0002633)2.66293899
39Recurrent viral infections (HP:0004429)2.64402890
40Periodontitis (HP:0000704)2.62558935
41Gastrointestinal infarctions (HP:0005244)2.62233207
42Mediastinal lymphadenopathy (HP:0100721)2.60432718
43Abnormality of the endocardium (HP:0004306)2.59129105
44Spontaneous hematomas (HP:0007420)2.58326011
45Dilatation of the ascending aorta (HP:0005111)2.54033306
46Gingivitis (HP:0000230)2.53492118
47Subacute progressive viral hepatitis (HP:0006572)2.53119390
48Pulmonary infiltrates (HP:0002113)2.52703850
49Keratoconjunctivitis sicca (HP:0001097)2.48378102
50Abnormality of T cells (HP:0002843)2.47712567
51Vacuolated lymphocytes (HP:0001922)2.45935518
52Abnormality of the nasal mucosa (HP:0000433)2.45463246
53Amyloidosis (HP:0011034)2.42825109
54Asymmetric septal hypertrophy (HP:0001670)2.41694870
55Esophageal varix (HP:0002040)2.40141688
56Prolonged bleeding time (HP:0003010)2.39799909
57Recurrent skin infections (HP:0001581)2.38830476
58Anorexia (HP:0002039)2.37658894
59Persistence of primary teeth (HP:0006335)2.37596534
60Nasal polyposis (HP:0100582)2.33499353
61Keratoconjunctivitis (HP:0001096)2.33363128
62Episodic fever (HP:0001954)2.33083177
63Gangrene (HP:0100758)2.32681228
64Epistaxis (HP:0000421)2.31916474
65Pulmonary embolism (HP:0002204)2.31563312
66Leukocytosis (HP:0001974)2.30248534
67Sudden death (HP:0001699)2.28582122
68Eosinophilia (HP:0001880)2.28086682
69Atrophic scars (HP:0001075)2.26009247
70Chronic otitis media (HP:0000389)2.25642678
71Hypergammaglobulinemia (HP:0010702)2.25609107
72Absent frontal sinuses (HP:0002688)2.20820937
73Hemoptysis (HP:0002105)2.20112484
74Abnormality of T cell number (HP:0011839)2.20077857
75Subaortic stenosis (HP:0001682)2.19343916
76Abnormality of the left ventricular outflow tract (HP:0011103)2.19343916
77Vertigo (HP:0002321)2.18553859
78Slow saccadic eye movements (HP:0000514)2.17828768
79Spondylolisthesis (HP:0003302)2.15485242
80Abnormal delayed hypersensitivity skin test (HP:0002963)2.14010423
81Pustule (HP:0200039)2.13309537
82Tetraparesis (HP:0002273)2.12778280
83Increased cerebral lipofuscin (HP:0011813)2.12707441
84Abnormality of the pleura (HP:0002103)2.11454146
85Fatigue (HP:0012378)2.11185398
86Gingival bleeding (HP:0000225)2.10890276
87Mitral valve prolapse (HP:0001634)2.09589044
88Recurrent cutaneous fungal infections (HP:0011370)2.08653619
89Chronic mucocutaneous candidiasis (HP:0002728)2.08653619
90Polycythemia (HP:0001901)2.08406884
91Ventricular tachycardia (HP:0004756)2.07428783
92Systemic lupus erythematosus (HP:0002725)2.07258362
93EMG: myopathic abnormalities (HP:0003458)2.06679289
94Distal lower limb muscle weakness (HP:0009053)2.05701326
95Viral hepatitis (HP:0006562)2.05580485
96Increased IgE level (HP:0003212)2.04608891
97Cellulitis (HP:0100658)2.04434619
98Abnormality of skeletal muscle fiber size (HP:0012084)2.04331249
99Increased connective tissue (HP:0009025)2.01998080
100Emphysema (HP:0002097)2.00065666
101Increased variability in muscle fiber diameter (HP:0003557)1.99615085
102Vascular tortuosity (HP:0004948)1.99234167
103Hypochromic microcytic anemia (HP:0004840)1.98615519
104Wormian bones (HP:0002645)1.98461631
105Aneurysm (HP:0002617)1.97548932
106Bundle branch block (HP:0011710)1.94009260
107Thrombocytosis (HP:0001894)1.93517581
108Recurrent bronchitis (HP:0002837)1.93484534
109Chest pain (HP:0100749)1.93455474
110Thick nail (HP:0001805)1.92969754
111Facial diplegia (HP:0001349)1.92501949
112Ventricular fibrillation (HP:0001663)1.91044731
113Acute hepatic failure (HP:0006554)1.90754589
114Sepsis (HP:0100806)1.89549052
115Keratitis (HP:0000491)1.88774423
116Resting tremor (HP:0002322)1.88647820
117Abnormality of the pericardium (HP:0001697)1.88469299
118Inflammation of the large intestine (HP:0002037)1.88108987
119Radial bowing (HP:0002986)1.87011957
120Soft skin (HP:0000977)1.85634373
121Shallow orbits (HP:0000586)1.85439893
122Obstructive lung disease (HP:0006536)1.85425394
123Chronic obstructive pulmonary disease (HP:0006510)1.85425394
124Granulocytopenia (HP:0001913)1.84516062
125Polyneuropathy (HP:0001271)1.82920262
126IgA deficiency (HP:0002720)1.82776501
127Increased neuronal autofluorescent lipopigment (HP:0002074)1.82620791
128Broad metatarsal (HP:0001783)1.82390430
129Abnormality of the peritoneum (HP:0002585)1.82341191
130Autoimmune hemolytic anemia (HP:0001890)1.81770949
131Syringomyelia (HP:0003396)1.81292737
132Spinal cord lesions (HP:0100561)1.81292737
133Hypochromic anemia (HP:0001931)1.81175587
134Glomerulopathy (HP:0100820)1.80963217
135Colitis (HP:0002583)1.80947033
136Ulnar bowing (HP:0003031)1.80057996
137Gastrointestinal inflammation (HP:0004386)1.79842835
138Skin ulcer (HP:0200042)1.78278012
139Stomatitis (HP:0010280)1.77995482
140Ventricular arrhythmia (HP:0004308)1.77921564
141Abnormality of T cell physiology (HP:0011840)1.77036033
142Basal ganglia calcification (HP:0002135)1.76870463
143Osteomyelitis (HP:0002754)1.75764569
144Nemaline bodies (HP:0003798)1.75535278
145Bicuspid aortic valve (HP:0001647)1.74853778

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K144.05455815
2TYK23.12036078
3JAK32.91435976
4TBK12.77159605
5TTN2.58693651
6EPHB12.40939808
7IKBKB2.34109522
8JAK12.32001507
9MAP4K12.11673011
10IKBKE2.10002959
11IRAK42.01627756
12EPHA31.94656828
13ERN11.94029714
14TRIB31.92853776
15FGFR41.92503537
16CHUK1.89512997
17TXK1.87366512
18TGFBR21.80937698
19MAP3K131.79634739
20GRK61.79429363
21FES1.74624202
22PRPF4B1.74258724
23NEK91.73575106
24BLK1.68856427
25KIT1.66660018
26STK101.66175147
27ZAP701.60905123
28IRAK31.58269013
29FGFR31.56196569
30RIPK11.55023353
31PTK61.51496103
32MAP3K61.51086534
33CSK1.49286179
34TAOK11.43602715
35LRRK21.38702586
36PIM21.32498098
37BMPR21.31121877
38DMPK1.29992369
39MAP3K21.26077252
40MAP3K11.23351475
41OBSCN1.22174948
42TRPM71.21837796
43MYLK1.19899838
44KSR21.19669303
45YES11.17239136
46TEC1.14771416
47FLT31.14521421
48PAK41.10980779
49NUAK11.09947333
50IRAK21.09021124
51TNK21.08540401
52GRK71.08442136
53MST41.07684208
54MAP3K31.06429975
55PIM11.05716273
56MARK21.04889746
57TAOK31.03949822
58PKN21.02631333
59HCK0.99997454
60WNK10.99117871
61TESK10.98791938
62RPS6KA40.98569995
63EPHA20.98137239
64CDC42BPA0.97013789
65CSF1R0.96717100
66JAK20.96534964
67ITK0.96223617
68CDK60.95049501
69CAMK1D0.94640630
70BMX0.94279970
71PDGFRA0.93770104
72STK30.92989263
73RIPK40.91540194
74KDR0.89535750
75MAP3K110.89530889
76MAP3K50.88840458
77SIK30.88783273
78BTK0.88596460
79LCK0.86892990
80MAP3K70.85155230
81DDR20.82056298
82SGK30.80606076
83TAOK20.80258062
84MAPKAPK20.78616266
85SIK10.77308859
86CDK120.73295026
87PDGFRB0.72793871
88NLK0.72063591
89MAP2K30.71315518
90SYK0.69976060
91MAPK120.69448320
92SGK20.68593720
93PTK20.66545223
94PDK10.65689171
95STK380.63010543
96MAP2K20.61975922
97FGR0.61414441
98FRK0.58565351
99MAPK70.58227887
100KSR10.58109515
101GSK3A0.58081265
102MARK30.57787560
103HIPK20.57340541
104TGFBR10.56171819
105PDPK10.56031942
106RAF10.55728969
107ABL10.55353772
108PAK20.55082813
109IRAK10.54066115
110EGFR0.53302801
111PRKD20.52628530
112PRKD10.51512663
113FYN0.51227752
114PRKAA20.49988399
115MAP2K40.49454700
116STK40.49358867
117TIE10.47494815
118PIK3CG0.47419068
119STK110.47177885
120PRKCQ0.46198602
121STK240.45967663
122RPS6KC10.44887477
123RPS6KL10.44887477
124MATK0.42263561
125DYRK1B0.40299052
126CAMK40.39789686
127FER0.39367695
128MAP3K100.39084645
129LYN0.38919474
130MAP3K80.38418726
131PIK3CA0.37709728
132INSR0.37038124
133PRKG20.36646210
134PTK2B0.36184892
135PRKCD0.35680093
136RET0.32953306
137ILK0.32893364
138EEF2K0.32570665
139IGF1R0.32207536
140MTOR0.31034121
141CAMK1G0.30327389

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051402.85008965
2NF-kappa B signaling pathway_Homo sapiens_hsa040642.66405844
3Allograft rejection_Homo sapiens_hsa053302.55187504
4Intestinal immune network for IgA production_Homo sapiens_hsa046722.35506442
5Graft-versus-host disease_Homo sapiens_hsa053322.28288147
6Osteoclast differentiation_Homo sapiens_hsa043802.25400537
7Measles_Homo sapiens_hsa051622.15697158
8Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.14354303
9Toxoplasmosis_Homo sapiens_hsa051452.08834420
10Toll-like receptor signaling pathway_Homo sapiens_hsa046202.08153068
11TNF signaling pathway_Homo sapiens_hsa046682.03344591
12Malaria_Homo sapiens_hsa051441.92376063
13NOD-like receptor signaling pathway_Homo sapiens_hsa046211.85997900
14Viral myocarditis_Homo sapiens_hsa054161.79671589
15Antigen processing and presentation_Homo sapiens_hsa046121.77644696
16Legionellosis_Homo sapiens_hsa051341.77376131
17RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.73408377
18Staphylococcus aureus infection_Homo sapiens_hsa051501.66914726
19Apoptosis_Homo sapiens_hsa042101.66860885
20Autoimmune thyroid disease_Homo sapiens_hsa053201.64819669
21Jak-STAT signaling pathway_Homo sapiens_hsa046301.62867745
22Pertussis_Homo sapiens_hsa051331.61154004
23Influenza A_Homo sapiens_hsa051641.57905689
24Leukocyte transendothelial migration_Homo sapiens_hsa046701.55058797
25Shigellosis_Homo sapiens_hsa051311.53957693
26Tuberculosis_Homo sapiens_hsa051521.53513128
27AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.44208260
28B cell receptor signaling pathway_Homo sapiens_hsa046621.42619853
29Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.42285380
30Non-small cell lung cancer_Homo sapiens_hsa052231.41296163
31Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.40164498
32Asthma_Homo sapiens_hsa053101.39475971
33Small cell lung cancer_Homo sapiens_hsa052221.38458687
34Herpes simplex infection_Homo sapiens_hsa051681.35191402
35Hematopoietic cell lineage_Homo sapiens_hsa046401.34807602
36Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.33566381
37Primary immunodeficiency_Homo sapiens_hsa053401.32083511
38Salmonella infection_Homo sapiens_hsa051321.29687727
39Chemokine signaling pathway_Homo sapiens_hsa040621.28727301
40ECM-receptor interaction_Homo sapiens_hsa045121.24004009
41T cell receptor signaling pathway_Homo sapiens_hsa046601.23267230
42Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.23081674
43Rheumatoid arthritis_Homo sapiens_hsa053231.22597093
44Hepatitis B_Homo sapiens_hsa051611.22265091
45Chronic myeloid leukemia_Homo sapiens_hsa052201.21336467
46Focal adhesion_Homo sapiens_hsa045101.20825982
47Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.18542939
48Amoebiasis_Homo sapiens_hsa051461.17202903
49Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.13322159
50Lysosome_Homo sapiens_hsa041421.12201012
51Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.10135889
52Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.08901623
53Other glycan degradation_Homo sapiens_hsa005111.08622282
54Acute myeloid leukemia_Homo sapiens_hsa052211.08414605
55Glycosaminoglycan degradation_Homo sapiens_hsa005311.07679965
56Adherens junction_Homo sapiens_hsa045201.05537216
57Dorso-ventral axis formation_Homo sapiens_hsa043201.04634896
58Proteoglycans in cancer_Homo sapiens_hsa052051.00658456
59Hepatitis C_Homo sapiens_hsa051600.99879703
60Pancreatic cancer_Homo sapiens_hsa052120.98744825
61Type I diabetes mellitus_Homo sapiens_hsa049400.95997964
62Platelet activation_Homo sapiens_hsa046110.94128420
63Prolactin signaling pathway_Homo sapiens_hsa049170.90760571
64African trypanosomiasis_Homo sapiens_hsa051430.90137620
65Adipocytokine signaling pathway_Homo sapiens_hsa049200.84730406
66Regulation of actin cytoskeleton_Homo sapiens_hsa048100.84215633
67MicroRNAs in cancer_Homo sapiens_hsa052060.82518480
68Phagosome_Homo sapiens_hsa041450.82394608
69Viral carcinogenesis_Homo sapiens_hsa052030.80735780
70p53 signaling pathway_Homo sapiens_hsa041150.80513406
71Transcriptional misregulation in cancer_Homo sapiens_hsa052020.80041938
72Endometrial cancer_Homo sapiens_hsa052130.79405003
73HTLV-I infection_Homo sapiens_hsa051660.77703899
74mTOR signaling pathway_Homo sapiens_hsa041500.75864041
75Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.75653815
76Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.75550563
77Epstein-Barr virus infection_Homo sapiens_hsa051690.74776262
78Insulin resistance_Homo sapiens_hsa049310.72718654
79HIF-1 signaling pathway_Homo sapiens_hsa040660.72112359
80Sphingolipid signaling pathway_Homo sapiens_hsa040710.71986193
81GnRH signaling pathway_Homo sapiens_hsa049120.69358545
82Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.68368015
83Phospholipase D signaling pathway_Homo sapiens_hsa040720.68083321
84Phosphatidylinositol signaling system_Homo sapiens_hsa040700.67022255
85Neurotrophin signaling pathway_Homo sapiens_hsa047220.63581475
86Inositol phosphate metabolism_Homo sapiens_hsa005620.61344457
87Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.60868414
88Insulin signaling pathway_Homo sapiens_hsa049100.59162746
89Prostate cancer_Homo sapiens_hsa052150.58045563
90Glioma_Homo sapiens_hsa052140.57209221
91Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.56225326
92Pathways in cancer_Homo sapiens_hsa052000.55406685
93Notch signaling pathway_Homo sapiens_hsa043300.54791171
94Protein digestion and absorption_Homo sapiens_hsa049740.54696714
95Carbohydrate digestion and absorption_Homo sapiens_hsa049730.53726171
96Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.53484862
97ErbB signaling pathway_Homo sapiens_hsa040120.53335929
98Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.51972988
99Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.51695924
100Type II diabetes mellitus_Homo sapiens_hsa049300.51636071
101Choline metabolism in cancer_Homo sapiens_hsa052310.51423262
102Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.51358270
103Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.50897598
104FoxO signaling pathway_Homo sapiens_hsa040680.50253328
105Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.49662308
106Endocytosis_Homo sapiens_hsa041440.49471444
107Longevity regulating pathway - mammal_Homo sapiens_hsa042110.49304629
108VEGF signaling pathway_Homo sapiens_hsa043700.49027459
109Caffeine metabolism_Homo sapiens_hsa002320.48599506
110Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.46974331
111Dilated cardiomyopathy_Homo sapiens_hsa054140.46759207
112Thyroid hormone signaling pathway_Homo sapiens_hsa049190.46437414
113PI3K-Akt signaling pathway_Homo sapiens_hsa041510.45688087
114Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.44727123
115Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.42198028
116Renin-angiotensin system_Homo sapiens_hsa046140.39824324
117Bladder cancer_Homo sapiens_hsa052190.39373219
118Renal cell carcinoma_Homo sapiens_hsa052110.39039935
119Colorectal cancer_Homo sapiens_hsa052100.37908241
120TGF-beta signaling pathway_Homo sapiens_hsa043500.36914062
121MAPK signaling pathway_Homo sapiens_hsa040100.32070597
122Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.30121060

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